Hub : Traits

Reaction time mean

Average of all reaction times for males and females [cs]

Tags: Behavior · Reaction time

Project: p50_david_dietz

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr9	75969545	77365260	1	1	1.24e-12	5.39e-02	1.00e+00	Zfand2b
2	chr19	32676171	34074113	1	1	6.24e-09	1.22e-01	1.12e-06	Zdhhc1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	50	0	1e+00	Zfand2b
BMI without tail	53.65	1	1	50	0	1e+00	Zfand2b
Epididymis fat weight	57.61	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Heart weight	71.7	1	1	50	0	1e+00	Zfand2b
Left kidney weight	19.82	2	2	100	0	1e+00	Zdhhc1 Zfand2b
Right kidney weight	33.45	2	2	100	0	1e+00	Zdhhc1 Zfand2b
Tail length	125.62	1	1	50	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	50	0	1e+00	Zfand2b
Liver weight, right	17.57	1	1	50	0	1e+00	Zfand2b
Parametrial fat weight	9.74	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Retroperitoneal fat weight	5.11	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Intraocular pressure	28.08	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Tibialis anterior weight	1.65	1	0	0	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	50	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	50	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1e+00	Zfand2b
Patch foraging indifference point AUC	16.01	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Indifference point function ln k	54.42	1	1	50	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	50	0	1e+00	Zfand2b
Patch foraging total patch changes 12 sec	4.12	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Patch foraging total patch changes 18 sec	26.19	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Patch foraging total patch changes 24 sec	42.21	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Patch foraging total patch changes 6 sec	14.42	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	50	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	7.84	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	20.78	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Locomotor activity	10.45	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Locomotor testing distance	47.2	1	1	50	0	1e+00	Zfand2b
Locomotor testing rearing	52.87	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Light reinforcement 1	14.51	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Light reinforcement 2	5.74	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Reaction time number correct	60.58	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time mean minus median	179.03	1	1	50	0	1e+00	Zfand2b
Reaction time mean minus median AUC	119.61	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	50	0	1e+00	Zfand2b
Reaction time trials correct on left	60.58	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials on left	56.77	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time mean AUC	26.7	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Median of all reaction times	22.05	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time omissions	46.56	1	1	50	0	1e+00	Zfand2b
Reaction time false alarm rate	3.92	1	0	0	0	1e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	50	0	1e+00	Zfand2b
Std. dev. reaction times	40.77	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials completed	56.77	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Reaction time trials AUC	57.6	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Social response proportion	8.47	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Conditioned locomotion	5.5	1	0	0	0	1e+00	Zdhhc1
Cocaine response after cond. corrected	12.71	1	0	0	0	1e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	50	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	50	0	1e+00	Zfand2b
Conditioned locomotion	10.02	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	50	0	1e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	50	0	1e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	50	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	151.36	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Intermittent access day 1 total infusions	40.73	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Intermittent access day 15 total infusions	24.75	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Intermittent access terminal intake (last 3 days)	16.73	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Intermittent access total infusions	13.02	1	0	0	0	1e+00	Zdhhc1
Intermittent access day 1 locomotion	26.47	1	1	50	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	50	0	1e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	50	0	1e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	50	0	1e+00	Zfand2b
Post-drug Anxiety	8.64	1	0	0	0	1e+00	Zdhhc1
Baseline Anxiety	393.92	1	1	50	0	1e+00	Zfand2b
Lifetime Intake	12.87	1	0	0	0	1e+00	Zdhhc1
Incentive Sensitization - Responses	169.87	2	2	100	0	1e+00	Zdhhc1 Zfand2b
Incentive Sensitization - Breakpoint	165.51	2	2	100	0	1e+00	Zdhhc1 Zfand2b
Progressive ratio test 1 active lever presses	19	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Progressive ratio test 1 breakpoint	12.07	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Progressive ratio test 1 inactive lever presses	5.43	1	0	0	0	1e+00	Zdhhc1
Progressive ratio test 2 active lever presses	67.87	2	2	100	0	1e+00	Zdhhc1 Zfand2b
Progressive ratio test 2 breakpoint	63.74	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	50	0	1e+00	Zfand2b
Total sessions with >9 infusions	48.24	1	1	50	0	1e+00	Zdhhc1
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	25.65	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Short access day 1 total infusions	19.14	1	0	0	0	1e+00	Zdhhc1
Short access day 10 total infusions	7.41	1	0	0	0	1e+00	Zdhhc1
Short access total infusions	8.06	1	0	0	0	1e+00	Zdhhc1
Short access day 1 locomotion	129.19	1	1	50	0	1e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	50	0	1e+00	Zfand2b
Short access total locomotion	209.96	1	1	50	0	1e+00	Zfand2b
Compulsive drug intake	68.39	1	1	50	0	1e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
One hour access (shock baseline)	14.65	1	0	0	0	1e+00	Zdhhc1
Number of responses in last shaping day	40.65	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Bone surface	3.9	1	0	0	0	1e+00	Zdhhc1
Bone volume	4.11	1	0	0	0	1e+00	Zdhhc1
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Bone: trabecular number	3.43	1	0	0	0	1e+00	Zdhhc1
Distance traveled before self-admin	27.99	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Distance traveled after self-admin	8.9	1	0	0	0	1e+00	Zfand2b
Delta time in open arm before/after self-admin	19.84	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Extinction: sum of active levers before priming	6.15	1	0	0	0	1e+00	Zdhhc1
Active lever presses in extinction session 6	18.22	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Delta ambulatory time before/after self-admin	11.38	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Time in closed arm before self-admin	28.56	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Time in closed arm after self-admin	7.24	1	0	0	0	1e+00	Zdhhc1
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, before self-admin	18.85	1	0	0	0	1e+00	Zdhhc1
Time to tail flick, vehicle, after self-admin	75.62	1	1	50	0	1e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	5.47	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	50	0	1e+00	Zfand2b
Ambulatory time before self-admin	29.88	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Ambulatory time after self-admin	4.73	1	0	0	0	1e+00	Zfand2b
Area under the delay curve	31.15	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	50	0	1e+00	Zfand2b
Delay disc. indifference point, 2s delay	7.52	1	0	0	0	1e+00	Zdhhc1
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	50	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	50	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	47.52	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	8.65	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Distance moved, locomotor task time 1	5.4	1	0	0	0	1e+00	Zdhhc1
Vertical activity count, locomotor time 1	51.28	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Time >=10cm from walls, locomotor time 2	5.83	1	0	0	0	1e+00	Zdhhc1
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	50	0	1e+00	Zfand2b
Rest time, locomotor task time 2	30.26	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Distance moved, locomotor task time 2	50.91	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Vertical activity count, locomotor time 2	12.25	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Progressive ratio	22.47	1	0	0	0	1e+00	Zdhhc1
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	7.06	2	0	0	0	1e+00	Zdhhc1 Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	50	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	50	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	20.83	2	1	50	0	1e+00	Zdhhc1 Zfand2b
Latency to leave start box in cocaine runway, M	42.07	1	1	50	0	1e+00	Zdhhc1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.33
Adipose	alternative TSS	0	0	1.33
Adipose	gene expression	0	0	1.38
Adipose	isoform ratio	0	0	1.36
Adipose	intron excision ratio	0	0	1.45
Adipose	mRNA stability	0	0	1.4
BLA	alternative polyA	0	0	1.45
BLA	alternative TSS	0	0	1.4
BLA	gene expression	0	0	1.37
BLA	isoform ratio	0	0	1.38
BLA	intron excision ratio	0	0	1.46
BLA	mRNA stability	0	0	1.43
Brain	alternative polyA	0	0	1.39
Brain	alternative TSS	0	0	1.47
Brain	gene expression	0	0	1.39
Brain	isoform ratio	0	0	1.42
Brain	intron excision ratio	0	0	1.49
Brain	mRNA stability	0	0	1.38
Eye	alternative polyA	0	0	1.33
Eye	alternative TSS	0	0	1.32
Eye	gene expression	0	0	1.41
Eye	isoform ratio	0	0	1.29
Eye	intron excision ratio	0	0	1.58
Eye	mRNA stability	0	0	1.4
IL	alternative polyA	0	0	1.37
IL	alternative TSS	0	0	1.46
IL	gene expression	0	0	1.36
IL	isoform ratio	0	0	1.42
IL	intron excision ratio	0	0	1.49
IL	mRNA stability	0	0	1.45
LHb	alternative polyA	0	0	1.3
LHb	alternative TSS	0	0	1.48
LHb	gene expression	0	0	1.37
LHb	isoform ratio	0	0	1.4
LHb	intron excision ratio	0	0	1.65
LHb	mRNA stability	0	0	1.41
Liver	alternative polyA	0	0	1.36
Liver	alternative TSS	0	0	1.33
Liver	gene expression	0	0	1.32
Liver	isoform ratio	0	0	1.35
Liver	intron excision ratio	0	0	1.37
Liver	mRNA stability	0	0	1.32
NAcc	alternative polyA	0	0	1.39
NAcc	alternative TSS	0	0	1.43
NAcc	gene expression	0	0	1.39
NAcc	isoform ratio	0	0	1.39
NAcc	intron excision ratio	0	0	1.43
NAcc	mRNA stability	1	0	1.37
OFC	alternative polyA	0	0	1.35
OFC	alternative TSS	0	0	1.41
OFC	gene expression	0	0	1.35
OFC	isoform ratio	0	0	1.41
OFC	intron excision ratio	0	0	1.47
OFC	mRNA stability	0	0	1.43
PL	alternative polyA	0	0	1.43
PL	alternative TSS	0	0	1.46
PL	gene expression	0	0	1.4
PL	isoform ratio	0	0	1.4
PL	intron excision ratio	1	0	1.47
PL	mRNA stability	0	0	1.38
pVTA	alternative polyA	0	0	1.34
pVTA	alternative TSS	0	0	1.51
pVTA	gene expression	0	0	1.41
pVTA	isoform ratio	0	0	1.36
pVTA	intron excision ratio	0	0	1.48
pVTA	mRNA stability	0	0	1.51
RMTg	alternative polyA	0	0	1.52
RMTg	alternative TSS	0	0	1.47
RMTg	gene expression	0	0	1.4
RMTg	isoform ratio	0	0	1.4
RMTg	intron excision ratio	0	0	1.5
RMTg	mRNA stability	0	0	1.5