Hub : Traits

Time in closed arm after self-admin

Time spent in the closed arm during the second time point of elevated plus maze after self admin

Tags: Behavior · Heroin · Elevated plus maze

Project: u01_peter_kalivas

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr4	10085840	10964652	1	1	2.94e-09	1.05e-01	9.51e-05	Abcb8

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.61	1	0	0	0	1e+00	Abcb8
BMI without tail	2.45	1	0	0	0	1e+00	Abcb8
Right kidney weight	1.88	1	0	0	0	1e+00	Abcb8
Length with tail	1.06	1	0	0	0	1e+00	Abcb8
Length without tail	2.32	1	0	0	0	1e+00	Abcb8
Food consumed during 24 hour testing period	4.57	1	0	0	0	1e+00	Abcb8
Patch foraging indifference point 0 sec	6.28	1	0	0	0	1e+00	Abcb8
Patch foraging total patch changes 0 sec	6.05	1	0	0	0	1e+00	Abcb8
Patch foraging total patch changes 6 sec	5.19	1	0	0	0	1e+00	Abcb8
Patch foraging water rate 12 sec	7.82	1	0	0	0	1e+00	Abcb8
Light reinforcement 1	2.63	1	0	0	0	1e+00	Abcb8
Light reinforcement 2	2.91	1	0	0	0	1e+00	Abcb8
Reaction time num false alarms	4.36	1	0	0	0	1e+00	Abcb8
Reaction time num false alarms AUC	3.62	1	0	0	0	1e+00	Abcb8
Reaction time omissions	13.34	1	0	0	0	1e+00	Abcb8
Reaction time premature initiations	5.75	1	0	0	0	1e+00	Abcb8
Cocaine response after cond. corrected	4.68	1	0	0	0	1e+00	Abcb8
Conditioned reinforcement - actives	10.78	1	0	0	0	1e+00	Abcb8
Intermittent access intake escalation 2	20.96	1	0	0	0	1e+00	Abcb8
Intermittent access day 1 total infusions	3.32	1	0	0	0	1e+00	Abcb8
Intermittent access total infusions	3.9	1	0	0	0	1e+00	Abcb8
Intermittent access total locomotion	4.67	1	0	0	0	1e+00	Abcb8
Cocaine induced anxiety	7.96	1	0	0	0	1e+00	Abcb8
Baseline Anxiety	11.67	1	0	0	0	1e+00	Abcb8
Incentive Sensitization - Responses	11.93	1	0	0	0	1e+00	Abcb8
Incentive Sensitization - Breakpoint	11.74	1	0	0	0	1e+00	Abcb8
Progressive ratio test 1 breakpoint	4.28	1	0	0	0	1e+00	Abcb8
Progressive ratio test 2 active lever presses	4.65	1	0	0	0	1e+00	Abcb8
Progressive ratio test 2 breakpoint	4.28	1	0	0	0	1e+00	Abcb8
Progressive ratio test 2 inactive lever presses	3.83	1	0	0	0	1e+00	Abcb8
Short access day 1 total inactive lever presses	23.74	1	0	0	0	1e+00	Abcb8
Short access day 10 total inactive lever presses	4.68	1	0	0	0	1e+00	Abcb8
Short access day 1 total infusions	3.98	1	0	0	0	1e+00	Abcb8
Short access day 10 total infusions	8.23	1	0	0	0	1e+00	Abcb8
Short access day 1 locomotion	14.94	1	0	0	0	1e+00	Abcb8
Short access day 10 total locomotion	6.24	1	0	0	0	1e+00	Abcb8
Compulsive drug intake	14.15	1	0	0	0	1e+00	Abcb8
Number of responses in last shaping day	11.75	1	0	0	0	1e+00	Abcb8
Locomotion velocity, session 2	3.69	1	0	0	0	1e+00	Abcb8
Locomotion distance, session 3	3.9	1	0	0	0	1e+00	Abcb8
Stereotopy head waving duration, day 7	4.21	1	0	0	0	1e+00	Abcb8
Locomotion distance, session 8	2.98	1	0	0	0	1e+00	Abcb8
Condit. Reinf. active minus inactive responses	16.72	1	0	0	0	1e+00	Abcb8
Condit. Reinf. active-inactive response ratio	8.58	1	0	0	0	1e+00	Abcb8
Condit. Reinf. active responses	16.06	1	0	0	0	1e+00	Abcb8
Incentive salience index mean	13.29	1	0	0	0	1e+00	Abcb8
Condit. Reinf. lever presses	4.61	1	0	0	0	1e+00	Abcb8
Time in novel zone, hab. session 1	8.85	1	0	0	0	1e+00	Abcb8
Total locomotion distance, NPP test	3.02	1	0	0	0	1e+00	Abcb8
Locomotion velocity, NPP test	2.92	1	0	0	0	1e+00	Abcb8
Pavlov. Cond. intertrial magazine entries	5.02	1	0	0	0	1e+00	Abcb8
Bone: apparent density	4.12	1	0	0	0	1e+00	Abcb8
Bone surface	2.76	1	0	0	0	1e+00	Abcb8
Bone volume	3.86	1	0	0	0	1e+00	Abcb8
Bone: connectivity density	3.27	1	0	0	0	1e+00	Abcb8
Bone: cortical area	6.9	1	0	0	0	1e+00	Abcb8
Bone: cortical thickness	4.69	1	0	0	0	1e+00	Abcb8
Bone: maximum diameter	3.67	1	0	0	0	1e+00	Abcb8
Bone: periosteal estimation	1.87	1	0	0	0	1e+00	Abcb8
Bone: periosteal perimeter	3.51	1	0	0	0	1e+00	Abcb8
Bone: post-yield work	2.92	1	0	0	0	1e+00	Abcb8
Bone: trabecular number	6.09	1	0	0	0	1e+00	Abcb8
Bone: trabecular thickness	5.88	1	0	0	0	1e+00	Abcb8
Distance traveled before self-admin	12.24	1	0	0	0	1e+00	Abcb8
Distance traveled after self-admin	11.43	1	0	0	0	1e+00	Abcb8
Delta time in open arm before/after self-admin	9.79	1	0	0	0	1e+00	Abcb8
Extinction: sum of active levers before priming	56.63	1	1	100	0	1e+00	Abcb8
Active lever presses in extinction session 6	6.45	1	0	0	0	1e+00	Abcb8
Delta distance traveled before/after self-admin	6.32	1	0	0	0	1e+00	Abcb8
Delta ambulatory time before/after self-admin	4.98	1	0	0	0	1e+00	Abcb8
Time in closed arm before self-admin	12.74	1	0	0	0	1e+00	Abcb8
Time in open arm after self-admin	24.75	1	1	100	0	1e+00	Abcb8
Sum of active levers in priming session hrs 5-6	35.31	1	1	100	0	1e+00	Abcb8
Time to tail flick, vehicle, before self-admin	16.02	1	0	0	0	1e+00	Abcb8
Time to tail flick, vehicle, after self-admin	8.93	1	0	0	0	1e+00	Abcb8
Time to tail flick, test, after self-admin	13.81	1	0	0	0	1e+00	Abcb8
Delta time to tail flick, vehicle, before/after SA	36.05	1	1	100	0	1e+00	Abcb8
Delta time to tail flick, test, before/after SA	23.62	1	0	0	0	1e+00	Abcb8
Ambulatory time before self-admin	12	1	0	0	0	1e+00	Abcb8
Ambulatory time after self-admin	19.34	1	0	0	0	1e+00	Abcb8
Delay disc. indifference point, 0s delay	3.66	1	0	0	0	1e+00	Abcb8
Delay disc. indifference point, 4s delay	22.33	1	0	0	0	1e+00	Abcb8
Bouts of movement, locomotor time 1	19.6	1	0	0	0	1e+00	Abcb8
Total resting periods, locomotor time 1	13.99	1	0	0	0	1e+00	Abcb8
Vertical activity count, locomotor time 1	6.85	1	0	0	0	1e+00	Abcb8
Bouts of movement, locomotor time 2	13.89	1	0	0	0	1e+00	Abcb8
Total resting periods, locomotor time 2	10.98	1	0	0	0	1e+00	Abcb8
Distance moved, locomotor task time 2	5.36	1	0	0	0	1e+00	Abcb8
Vertical activity count, locomotor time 2	4.78	1	0	0	0	1e+00	Abcb8
Weight adjusted by age	5.54	1	0	0	0	1e+00	Abcb8
Locomotion in novel chamber	11.46	1	0	0	0	1e+00	Abcb8
Food seeking constrained by brief footshock	19.3	1	0	0	0	1e+00	Abcb8
Run reversals in cocaine runway, females	18.55	1	0	0	0	1e+00	Abcb8
K content in liver	5.2	1	0	0	0	1e+00	Abcb8
Rb content in liver	3.9	1	0	0	0	1e+00	Abcb8

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.03
Adipose	alternative TSS	0	0	1.04
Adipose	gene expression	0	0	1.02
Adipose	isoform ratio	0	0	1.02
Adipose	intron excision ratio	0	0	0.94
Adipose	mRNA stability	0	0	1.03
BLA	alternative polyA	0	0	1.09
BLA	alternative TSS	0	0	1.08
BLA	gene expression	0	0	1.03
BLA	isoform ratio	0	0	1.03
BLA	intron excision ratio	0	0	1.02
BLA	mRNA stability	0	0	1.05
Brain	alternative polyA	0	0	1.03
Brain	alternative TSS	0	0	1.05
Brain	gene expression	0	0	1.04
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	1.04
Brain	mRNA stability	0	0	1.03
Eye	alternative polyA	0	0	0.88
Eye	alternative TSS	0	0	1.1
Eye	gene expression	0	0	1.01
Eye	isoform ratio	0	0	0.93
Eye	intron excision ratio	0	0	1.03
Eye	mRNA stability	0	0	1.04
IL	alternative polyA	0	0	1.08
IL	alternative TSS	0	0	1.07
IL	gene expression	0	0	1.02
IL	isoform ratio	0	0	1.06
IL	intron excision ratio	0	0	0.98
IL	mRNA stability	0	0	1.06
LHb	alternative polyA	0	0	1.05
LHb	alternative TSS	0	0	1.09
LHb	gene expression	0	0	0.98
LHb	isoform ratio	0	0	1.01
LHb	intron excision ratio	0	0	0.85
LHb	mRNA stability	0	0	1.02
Liver	alternative polyA	1	0	0.98
Liver	alternative TSS	0	0	0.99
Liver	gene expression	0	0	1.02
Liver	isoform ratio	0	0	1.01
Liver	intron excision ratio	0	0	0.99
Liver	mRNA stability	0	0	1
NAcc	alternative polyA	0	0	1.04
NAcc	alternative TSS	0	0	1.04
NAcc	gene expression	0	0	1.04
NAcc	isoform ratio	0	0	1.02
NAcc	intron excision ratio	0	0	1.01
NAcc	mRNA stability	0	0	1.06
OFC	alternative polyA	0	0	1
OFC	alternative TSS	0	0	0.95
OFC	gene expression	0	0	1.01
OFC	isoform ratio	0	0	1.05
OFC	intron excision ratio	0	0	0.9
OFC	mRNA stability	0	0	1.03
PL	alternative polyA	0	0	1.08
PL	alternative TSS	0	0	1.06
PL	gene expression	0	0	1.03
PL	isoform ratio	0	0	1.01
PL	intron excision ratio	0	0	1.01
PL	mRNA stability	0	0	1.05
pVTA	alternative polyA	0	0	1.06
pVTA	alternative TSS	0	0	1.01
pVTA	gene expression	0	0	1.03
pVTA	isoform ratio	0	0	1.04
pVTA	intron excision ratio	0	0	1.03
pVTA	mRNA stability	0	0	1.06
RMTg	alternative polyA	0	0	1.02
RMTg	alternative TSS	0	0	0.99
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1.01
RMTg	intron excision ratio	0	0	0.95
RMTg	mRNA stability	0	0	0.96