Hub : Traits

Intermittent access intake escalation 2

Average intermittent access infusions from days 12-15 minus average from days 1-3

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	33211184	34601262	1	1	1.07e-08	1.88e-03	1.06e-01	Ddx25

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1.62	1	0	0	0	1e+00	Ddx25
BMI without tail	4.08	1	0	0	0	1e+00	Ddx25
Right kidney weight	2.2	1	0	0	0	1e+00	Ddx25
Tail length	6.06	1	0	0	0	1e+00	Ddx25
Length without tail	5.12	1	0	0	0	1e+00	Ddx25
Parametrial fat weight	2.79	1	0	0	0	1e+00	Ddx25
Patch foraging indifference point 0 sec	2.95	1	0	0	0	1e+00	Ddx25
Patch foraging total patch changes 0 sec	3.04	1	0	0	0	1e+00	Ddx25
Patch foraging total patch changes 18 sec	3.59	1	0	0	0	1e+00	Ddx25
Locomotor activity	4.49	1	0	0	0	1e+00	Ddx25
Locomotor testing distance	4.75	1	0	0	0	1e+00	Ddx25
Locomotor testing rearing	3.33	1	0	0	0	1e+00	Ddx25
Reaction time mean minus median AUC	3.91	1	0	0	0	1e+00	Ddx25
Reaction time mean	4.79	1	0	0	0	1e+00	Ddx25
Reaction time mean AUC	3.43	1	0	0	0	1e+00	Ddx25
Median of all reaction times	3.49	1	0	0	0	1e+00	Ddx25
Conditioned reinforcement - inactives	14.96	1	0	0	0	1e+00	Ddx25
Intermittent access intake day 1-15 change	78.98	1	1	100	0	1e+00	Ddx25
Intermittent access intake escalation	41.26	1	1	100	0	1e+00	Ddx25
Intermitt. access day 1 inactive lever presses	25.7	1	1	100	0	1e+00	Ddx25
Intermitt. access day 15 inactive lever presses	40.88	1	1	100	0	1e+00	Ddx25
Intermitt. access escalation Index	14.59	1	0	0	0	1e+00	Ddx25
Intermittent access day 15 total infusions	44	1	1	100	0	1e+00	Ddx25
Intermittent access terminal intake (last 3 days)	43.95	1	1	100	0	1e+00	Ddx25
Intermittent access total infusions	25.36	1	1	100	0	1e+00	Ddx25
Intermittent access standard deviation	15.54	1	0	0	0	1e+00	Ddx25
Cocaine induced anxiety	12.68	1	0	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	0	1e+00	Ddx25
Lifetime Intake	42.99	1	1	100	0	1e+00	Ddx25
Incentive Sensitization - Responses	18.74	1	0	0	0	1e+00	Ddx25
Incentive Sensitization - Breakpoint	21.33	1	0	0	0	1e+00	Ddx25
Progressive ratio test 1 active lever presses	8.93	1	0	0	0	1e+00	Ddx25
Progressive ratio test 1 breakpoint	6.86	1	0	0	0	1e+00	Ddx25
Progressive ratio test 1 inactive lever presses	14.06	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 active lever presses	15.63	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 breakpoint	18.9	1	0	0	0	1e+00	Ddx25
Progressive ratio test 2 inactive lever presses	38.14	1	1	100	0	1e+00	Ddx25
Total sessions with >9 infusions	18.87	1	0	0	0	1e+00	Ddx25
Short access day 1 total infusions	50.43	1	1	100	0	1e+00	Ddx25
Short access day 10 total infusions	32.96	1	1	100	0	1e+00	Ddx25
Short access total infusions	54.56	1	1	100	0	1e+00	Ddx25
Short access day 1 locomotion	4.47	1	0	0	0	1e+00	Ddx25
Short access day 10 total locomotion	11.38	1	0	0	0	1e+00	Ddx25
One hour access (0.3 mA shock)	70.35	1	1	100	0	1e+00	Ddx25
One hour access (shock baseline)	40.39	1	1	100	0	1e+00	Ddx25
Number of responses in last shaping day	30.81	1	1	100	0	1e+00	Ddx25
Bone: cortical area	7.52	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1e+00	Ddx25
Bone: elastic work	3.45	1	0	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	0	1e+00	Ddx25
Bone: periosteal perimeter	2.39	1	0	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	0	1e+00	Ddx25
Bone: trabecular thickness	4.3	1	0	0	0	1e+00	Ddx25
Distance traveled before self-admin	16.17	1	0	0	0	1e+00	Ddx25
Distance traveled after self-admin	12.05	1	0	0	0	1e+00	Ddx25
Delta time in closed arm before/after self-admin	6.42	1	0	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	23.79	1	0	0	0	1e+00	Ddx25
Active lever presses in extinction session 6	9.49	1	0	0	0	1e+00	Ddx25
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	14.46	1	0	0	0	1e+00	Ddx25
Time in open arm after self-admin	4.49	1	0	0	0	1e+00	Ddx25
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	0	1e+00	Ddx25
Time to tail flick, test, before self-admin	5.88	1	0	0	0	1e+00	Ddx25
Delta time to tail flick, vehicle, before/after SA	4.75	1	0	0	0	1e+00	Ddx25
Ambulatory time before self-admin	28.62	1	1	100	0	1e+00	Ddx25
Ambulatory time after self-admin	5.62	1	0	0	0	1e+00	Ddx25
Total heroin consumption	8.9	1	0	0	0	1e+00	Ddx25
Bouts of movement, locomotor time 2	3.86	1	0	0	0	1e+00	Ddx25
Run reversals in cocaine runway, females	4.22	1	0	0	0	1e+00	Ddx25
Run reversals in cocaine runway, males	8.37	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	10.76	1	0	0	0	1e+00	Ddx25
Co content in liver	3.85	1	0	0	0	1e+00	Ddx25
Sr content in liver	9.74	1	0	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1
Adipose	alternative TSS	0	0	1
Adipose	gene expression	1	0	0.99
Adipose	isoform ratio	0	0	0.96
Adipose	intron excision ratio	0	0	1
Adipose	mRNA stability	0	0	0.97
BLA	alternative polyA	0	0	1
BLA	alternative TSS	0	0	0.99
BLA	gene expression	0	0	0.99
BLA	isoform ratio	0	0	0.96
BLA	intron excision ratio	0	0	0.97
BLA	mRNA stability	0	0	0.97
Brain	alternative polyA	0	0	1.01
Brain	alternative TSS	0	0	1.01
Brain	gene expression	0	0	1
Brain	isoform ratio	0	0	0.98
Brain	intron excision ratio	0	0	0.99
Brain	mRNA stability	0	0	0.98
Eye	alternative polyA	0	0	1.02
Eye	alternative TSS	0	0	1.12
Eye	gene expression	0	0	0.98
Eye	isoform ratio	0	0	1.17
Eye	intron excision ratio	0	0	1.09
Eye	mRNA stability	0	0	1.14
IL	alternative polyA	0	0	0.95
IL	alternative TSS	0	0	1.01
IL	gene expression	0	0	0.99
IL	isoform ratio	0	0	0.99
IL	intron excision ratio	0	0	0.97
IL	mRNA stability	0	0	0.95
LHb	alternative polyA	0	0	1.03
LHb	alternative TSS	0	0	1.1
LHb	gene expression	0	0	1.01
LHb	isoform ratio	0	0	0.95
LHb	intron excision ratio	0	0	0.94
LHb	mRNA stability	0	0	0.98
Liver	alternative polyA	0	0	0.97
Liver	alternative TSS	0	0	0.93
Liver	gene expression	0	0	0.97
Liver	isoform ratio	0	0	1
Liver	intron excision ratio	0	0	0.97
Liver	mRNA stability	0	0	0.96
NAcc	alternative polyA	0	0	0.99
NAcc	alternative TSS	0	0	1.05
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	0.95
NAcc	mRNA stability	0	0	1.01
OFC	alternative polyA	0	0	0.92
OFC	alternative TSS	0	0	1.04
OFC	gene expression	0	0	1
OFC	isoform ratio	0	0	1.01
OFC	intron excision ratio	0	0	0.95
OFC	mRNA stability	0	0	0.97
PL	alternative polyA	0	0	0.96
PL	alternative TSS	0	0	1.04
PL	gene expression	0	0	1.01
PL	isoform ratio	0	0	1
PL	intron excision ratio	0	0	0.97
PL	mRNA stability	0	0	0.99
pVTA	alternative polyA	0	0	1.01
pVTA	alternative TSS	0	0	1.1
pVTA	gene expression	0	0	0.99
pVTA	isoform ratio	0	0	0.99
pVTA	intron excision ratio	0	0	0.98
pVTA	mRNA stability	0	0	1.01
RMTg	alternative polyA	0	0	0.99
RMTg	alternative TSS	0	0	1.16
RMTg	gene expression	0	0	1.01
RMTg	isoform ratio	0	0	0.96
RMTg	intron excision ratio	0	0	0.93
RMTg	mRNA stability	0	0	1.06