| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000016777 | 0.1500 | 0.1800 | 1.1e-10 | 0.086 | 0.083 | 0.084 | 0.083 | 8.5e-10 | 1.8e-09 | 1.3e-09 | 1.7e-09 |
| 2 | Adipose | mRNA stability | ENSRNOG00000016777 | 0.2810 | 0.2860 | 0.0e+00 | 0.170 | 0.168 | 0.169 | 0.168 | 1.7e-18 | 2.7e-18 | 2.1e-18 | 2.8e-18 |
| 3 | BLA | gene expression | ENSRNOG00000016777 | 0.1484 | 0.1323 | 1.4e-05 | 0.081 | 0.080 | 0.081 | 0.081 | 4.1e-05 | 4.4e-05 | 4.0e-05 | 4.1e-05 |
| 4 | Brain | gene expression | ENSRNOG00000016777 | 0.0930 | 0.0880 | 3.7e-07 | 0.059 | 0.068 | 0.063 | 0.059 | 3.8e-06 | 6.3e-07 | 1.6e-06 | 3.3e-06 |
| 5 | Brain | mRNA stability | ENSRNOG00000016777 | 0.0775 | 0.0746 | 5.4e-06 | 0.052 | 0.060 | 0.053 | 0.052 | 1.3e-05 | 3.0e-06 | 1.1e-05 | 1.2e-05 |
| 6 | Liver | alternative TSS | ENSRNOT00000022706 | 0.1061 | 0.0911 | 6.8e-11 | 0.087 | 0.084 | 0.087 | 0.086 | 7.3e-10 | 1.3e-09 | 7.4e-10 | 9.4e-10 |
| 7 | Liver | alternative TSS | ENSRNOT00000101142 | 0.1076 | 0.0920 | 4.6e-11 | 0.088 | 0.085 | 0.088 | 0.087 | 5.6e-10 | 1.1e-09 | 5.6e-10 | 6.9e-10 |
| 8 | Liver | gene expression | ENSRNOG00000016777 | 0.4300 | 0.2300 | 0.0e+00 | 0.377 | 0.371 | 0.374 | 0.376 | 4.3e-44 | 3.1e-43 | 1.3e-43 | 6.0e-44 |
| 9 | Liver | mRNA stability | ENSRNOG00000016777 | 0.1134 | 0.1054 | 9.3e-11 | 0.089 | 0.089 | 0.091 | 0.090 | 3.9e-10 | 4.1e-10 | 2.8e-10 | 3.6e-10 |
| 10 | NAcc | gene expression | ENSRNOG00000016777 | 0.0740 | 0.0720 | 1.4e-04 | 0.045 | 0.048 | 0.045 | 0.044 | 2.8e-04 | 1.7e-04 | 2.9e-04 | 2.9e-04 |
| 11 | NAcc | mRNA stability | ENSRNOG00000016777 | 0.0366 | 0.0397 | 8.2e-03 | 0.016 | 0.014 | 0.033 | 0.012 | 2.2e-02 | 2.8e-02 | 1.6e-03 | 3.9e-02 |
| 12 | PL | gene expression | ENSRNOG00000016777 | 0.1354 | 0.1203 | 5.3e-08 | 0.091 | 0.092 | 0.092 | 0.092 | 2.2e-07 | 1.8e-07 | 1.9e-07 | 1.8e-07 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Extensor digitorum longus weight | 12.3 | 49.5 | 51.1 | -7.1 | -7.1 | 7.1 | 6.3 | 7.1 | 7.1 | -7.1 | -7.1 | -7.1 | 7.1 | 7.2 | 7.1 |
| Tibialis anterior weight | 7.9 | 27.3 | 27.9 | -5.3 | -5.3 | 5.3 | 4.8 | 5.3 | 5.2 | -5.3 | -5.2 | -5.3 | 5.3 | 5.3 | 5.3 |
| Pavlov. Cond. intertrial magazine entries | 6.1 | 7.9 | 8.4 | 2.8 | 2.8 | -2.9 | -2.4 | -2.8 | -2.9 | 2.9 | 2.9 | 2.9 | -2.8 | -2.9 | -2.8 |
| Bouts of movement, locomotor time 1 | 5.0 | 5.5 | 5.8 | -2.4 | -2.4 | 2.4 | 2.1 | 2.4 | 2.4 | -2.3 | -2.4 | -2.3 | 2.4 | 2.2 | 2.4 |
| Total resting periods, locomotor time 1 | 4.9 | 5.5 | 5.7 | -2.4 | -2.4 | 2.4 | 2.1 | 2.4 | 2.4 | -2.4 | -2.4 | -2.4 | 2.4 | 2.2 | 2.4 |
| Degree of sensitization distance | 4.6 | 4.6 | 5.1 | 2.1 | 2.1 | -2.3 | -1.7 | -2.2 | -2.2 | 2.3 | 2.2 | 2.3 | -2.2 | -1.9 | -2.2 |
| Locomotion velocity, session 7 | 4.2 | 4.6 | 4.8 | 2.2 | 2.2 | -2.2 | -2.0 | -2.2 | -2.2 | 2.2 | 2.2 | 2.2 | -2.2 | -1.9 | -2.2 |
| Total resting periods, locomotor time 2 | 4.2 | 4.5 | 5.0 | -2.2 | -2.2 | 2.1 | 2.1 | 2.1 | 2.1 | -2.1 | -2.1 | -2.1 | 2.1 | 2.0 | 2.1 |
| Co content in liver | 3.8 | 4.5 | 4.7 | -2.1 | -2.1 | 2.2 | 1.9 | 2.1 | 2.1 | -2.2 | -2.1 | -2.2 | 2.1 | 2.1 | 2.1 |
| Length without tail | 3.7 | 8.0 | 8.3 | -2.9 | -2.9 | 2.8 | 2.6 | 2.9 | 2.8 | -2.8 | -2.8 | -2.8 | 2.9 | 2.7 | 2.9 |
| Bouts of movement, locomotor time 2 | 3.7 | 4.0 | 4.5 | -2.1 | -2.1 | 1.9 | 2.0 | 2.0 | 2.0 | -1.9 | -2.0 | -1.9 | 2.0 | 1.8 | 2.0 |
| Run reversals in cocaine runway, females | 3.7 | 3.7 | 4.1 | 2.0 | 2.0 | -2.0 | -1.8 | -2.0 | -2.0 | 2.0 | 2.0 | 2.0 | -2.0 | -1.3 | -2.0 |
| Ambulatory time after self-admin | 3.6 | 4.0 | 5.3 | -2.0 | -2.0 | 1.9 | 2.3 | 2.0 | 1.8 | -1.9 | -1.8 | -1.9 | 2.0 | 2.1 | 2.0 |
| Parametrial fat weight | 3.5 | 6.8 | 7.4 | 2.6 | 2.6 | -2.7 | -2.2 | -2.6 | -2.7 | 2.7 | 2.7 | 2.7 | -2.6 | -2.5 | -2.6 |
| Light reinforcement 1 | 3.3 | 6.0 | 6.6 | 2.5 | 2.5 | -2.4 | -2.6 | -2.5 | -2.3 | 2.4 | 2.3 | 2.4 | -2.5 | -2.3 | -2.5 |
| Locomotion distance, session 7 | 3.3 | 4.2 | 4.5 | 2.0 | 2.0 | -2.1 | -1.7 | -2.1 | -2.1 | 2.1 | 2.1 | 2.1 | -2.1 | -2.0 | -2.1 |
| Time to tail flick, test, after self-admin | 3.3 | 3.3 | 3.5 | 1.8 | 1.8 | -1.9 | -1.6 | -1.9 | -1.8 | 1.9 | 1.8 | 1.9 | -1.9 | -1.8 | -1.9 |
| Rest time, locomotor task time 1 | 3.2 | 3.4 | 3.8 | -1.9 | -1.9 | 1.9 | 1.5 | 1.9 | 2.0 | -1.9 | -2.0 | -1.9 | 1.9 | 1.7 | 1.9 |
| Distance moved, locomotor task time 1 | 3.1 | 3.4 | 3.7 | 1.9 | 1.9 | -1.9 | -1.5 | -1.8 | -1.9 | 1.9 | 1.9 | 1.9 | -1.8 | -1.7 | -1.8 |
| Delay discounting water rate 18 sec | 2.9 | 3.9 | 4.8 | -2.1 | -2.1 | 1.9 | 2.2 | 2.0 | 1.8 | -1.9 | -1.8 | -1.9 | 2.0 | 2.2 | 2.0 |
| Conditioned reinforcement - inactives | 2.9 | 3.3 | 3.4 | 1.8 | 1.8 | -1.8 | -1.8 | -1.9 | -1.7 | 1.8 | 1.7 | 1.8 | -1.9 | -1.8 | -1.9 |
| Condit. Reinf. inactive responses | 2.9 | 3.4 | 3.6 | 1.9 | 1.9 | -1.9 | -1.6 | -1.9 | -1.8 | 1.9 | 1.8 | 1.9 | -1.9 | -1.8 | -1.9 |
| Bone: connectivity density | 2.8 | 4.4 | 4.9 | 2.1 | 2.1 | -2.2 | -1.7 | -2.1 | -2.2 | 2.2 | 2.2 | 2.2 | -2.1 | -1.8 | -2.1 |
| Diff in mean of infusions in LGA sessions | 2.8 | 3.2 | 4.5 | -1.7 | -1.7 | 1.9 | 0.8 | 1.7 | 2.0 | -1.9 | -2.0 | -1.9 | 1.7 | 2.1 | 1.7 |
| Conditioned reinforcement - actives | 2.7 | 2.6 | 2.8 | 1.7 | 1.7 | -1.6 | -1.5 | -1.6 | -1.6 | 1.6 | 1.6 | 1.6 | -1.6 | -1.7 | -1.6 |
| Distance moved, locomotor task time 2 | 2.7 | 3.1 | 3.7 | 1.8 | 1.8 | -1.8 | -1.3 | -1.7 | -1.9 | 1.8 | 1.9 | 1.8 | -1.8 | -1.6 | -1.8 |
| Stereotopy head waving duration, day 3 | 2.6 | 3.2 | 3.5 | -1.8 | -1.8 | 1.8 | 1.5 | 1.8 | 1.9 | -1.8 | -1.9 | -1.8 | 1.8 | 1.9 | 1.8 |
| Bone: trabecular number | 2.6 | 4.0 | 4.5 | 2.0 | 2.0 | -2.1 | -1.6 | -2.0 | -2.1 | 2.1 | 2.1 | 2.1 | -2.0 | -1.7 | -2.0 |
| Extinction: sum of active levers before priming | 2.6 | 2.6 | 3.2 | 1.6 | 1.6 | -1.6 | -1.3 | -1.6 | -1.8 | 1.6 | 1.8 | 1.6 | -1.6 | -1.4 | -1.6 |
| Total locomotion distance, NPP test | 2.5 | 3.5 | 4.1 | 1.9 | 1.9 | -1.8 | -2.0 | -1.9 | -1.8 | 1.8 | 1.8 | 1.8 | -1.9 | -2.0 | -1.9 |
| Stereotopy head waving duration, day 7 | 2.4 | 2.9 | 3.4 | -1.8 | -1.8 | 1.7 | 1.7 | 1.7 | 1.6 | -1.7 | -1.6 | -1.7 | 1.7 | 1.8 | 1.7 |
| Locomotion velocity, NPP test | 2.4 | 3.5 | 4.2 | 1.9 | 1.9 | -1.8 | -1.9 | -1.9 | -1.8 | 1.8 | 1.8 | 1.8 | -1.9 | -2.0 | -1.9 |
| Bone: trabecular spacing | 2.4 | 3.1 | 3.2 | -1.8 | -1.8 | 1.8 | 1.7 | 1.8 | 1.7 | -1.8 | -1.7 | -1.8 | 1.8 | 1.7 | 1.8 |
| Run reversals in cocaine runway, males | 2.4 | 2.3 | 2.4 | -1.5 | -1.5 | 1.5 | 1.4 | 1.5 | 1.5 | -1.5 | -1.5 | -1.5 | 1.5 | 1.5 | 1.5 |
| Indifference point 0 sec | 2.3 | 3.6 | 4.7 | 1.9 | 1.9 | -1.8 | -1.9 | -1.9 | -1.9 | 1.8 | 1.9 | 1.8 | -1.9 | -2.2 | -1.9 |
| Reaction time omissions | 2.3 | 3.0 | 4.4 | 1.8 | 1.8 | -1.6 | -2.1 | -1.8 | -1.6 | 1.6 | 1.6 | 1.6 | -1.7 | -1.9 | -1.7 |
| Condit. Reinf. inactive responses | 2.3 | 2.9 | 3.8 | 1.7 | 1.7 | -1.7 | -1.4 | -1.7 | -1.7 | 1.7 | 1.7 | 1.7 | -1.7 | -1.9 | -1.7 |
| Delta distance traveled before/after self-admin | 2.3 | 2.4 | 3.7 | -1.6 | -1.6 | 1.5 | 1.9 | 1.6 | 1.3 | -1.5 | -1.3 | -1.5 | 1.6 | 1.6 | 1.6 |
| Epididymis fat weight | 2.2 | 5.2 | 5.5 | 2.3 | 2.3 | -2.3 | -2.1 | -2.3 | -2.3 | 2.3 | 2.3 | 2.3 | -2.3 | -2.3 | -2.3 |
| Liver weight, left | 2.2 | 3.5 | 3.7 | -1.9 | -1.9 | 1.9 | 1.8 | 1.9 | 1.8 | -1.9 | -1.8 | -1.9 | 1.9 | 1.9 | 1.9 |
| Intermittent access intake day 1-15 change | 2.2 | 2.2 | 2.9 | 1.4 | 1.4 | -1.5 | -1.0 | -1.4 | -1.7 | 1.5 | 1.7 | 1.5 | -1.5 | -1.5 | -1.5 |
| Condit. Reinf. active-inactive response ratio | 2.2 | 2.4 | 2.9 | -1.5 | -1.5 | 1.7 | 1.0 | 1.6 | 1.7 | -1.7 | -1.7 | -1.7 | 1.6 | 1.2 | 1.6 |
| Distance traveled after self-admin | 2.2 | 2.5 | 3.5 | -1.6 | -1.6 | 1.5 | 1.8 | 1.6 | 1.4 | -1.5 | -1.4 | -1.5 | 1.6 | 1.9 | 1.6 |
| Delay discounting water rate 6 sec | 2.1 | 3.0 | 4.1 | -1.8 | -1.8 | 1.6 | 2.0 | 1.8 | 1.6 | -1.6 | -1.6 | -1.6 | 1.8 | 1.8 | 1.8 |
| Delta ambulatory time before/after self-admin | 2.1 | 2.3 | 3.7 | -1.5 | -1.5 | 1.4 | 1.9 | 1.6 | 1.3 | -1.4 | -1.3 | -1.4 | 1.6 | 1.5 | 1.6 |
| Fe content in liver | 2.1 | 2.5 | 2.7 | 1.6 | 1.6 | -1.6 | -1.4 | -1.6 | -1.6 | 1.6 | 1.6 | 1.6 | -1.6 | -1.6 | -1.6 |
| Mean time between licks in bursts | 2.0 | 2.8 | 3.0 | 1.7 | 1.7 | -1.7 | -1.5 | -1.7 | -1.7 | 1.7 | 1.7 | 1.7 | -1.7 | -1.7 | -1.7 |
| Reaction time premature initiations | 2.0 | 2.9 | 3.2 | -1.7 | -1.7 | 1.8 | 1.4 | 1.7 | 1.8 | -1.8 | -1.8 | -1.8 | 1.7 | 1.7 | 1.7 |
| Delta time in closed arm before/after self-admin | 2.0 | 1.9 | 2.0 | 1.4 | 1.4 | -1.4 | -1.3 | -1.4 | -1.4 | 1.4 | 1.4 | 1.4 | -1.4 | -1.3 | -1.4 |
| Time to tail flick, vehicle, after self-admin | 2.0 | 2.1 | 2.9 | -1.4 | -1.4 | 1.6 | 0.8 | 1.4 | 1.7 | -1.5 | -1.7 | -1.5 | 1.4 | 1.3 | 1.4 |
| Mn content in liver | 2.0 | 2.3 | 2.4 | 1.5 | 1.5 | -1.5 | -1.4 | -1.5 | -1.5 | 1.5 | 1.5 | 1.5 | -1.5 | -1.5 | -1.5 |
| Delay discounting total patch changes 0 sec | 1.9 | 3.0 | 3.9 | 1.7 | 1.7 | -1.7 | -1.7 | -1.7 | -1.7 | 1.7 | 1.7 | 1.7 | -1.7 | -2.0 | -1.7 |
| Delay discounting total patch changes 18 sec | 1.9 | 2.5 | 3.4 | 1.7 | 1.7 | -1.5 | -1.7 | -1.6 | -1.5 | 1.5 | 1.5 | 1.5 | -1.6 | -1.9 | -1.6 |
| Time in familiar zone, hab. session 2 | 1.9 | 2.0 | 2.1 | -1.4 | -1.4 | 1.4 | 1.4 | 1.4 | 1.4 | -1.4 | -1.4 | -1.4 | 1.4 | 1.4 | 1.4 |
| Weight adjusted by age | 1.8 | 2.0 | 2.3 | -1.4 | -1.4 | 1.5 | 1.1 | 1.4 | 1.5 | -1.5 | -1.5 | -1.5 | 1.4 | 1.4 | 1.4 |
| Stereotopy head waving bouts, day 7 | 1.7 | 1.9 | 2.3 | -1.5 | -1.5 | 1.3 | 1.5 | 1.4 | 1.3 | -1.3 | -1.3 | -1.3 | 1.4 | 1.5 | 1.4 |
| Time in closed arm before self-admin | 1.7 | 2.0 | 2.6 | -1.5 | -1.5 | 1.4 | 1.6 | 1.5 | 1.4 | -1.4 | -1.4 | -1.4 | 1.4 | 1.1 | 1.4 |
| Pavlov. Cond. change in total contacts | 1.6 | 2.2 | 2.3 | -1.5 | -1.5 | 1.5 | 1.3 | 1.5 | 1.5 | -1.5 | -1.5 | -1.5 | 1.5 | 1.5 | 1.5 |
| Delay disc. indifference point, 4s delay | 1.6 | 1.7 | 2.0 | -1.2 | -1.2 | 1.3 | 1.1 | 1.3 | 1.4 | -1.3 | -1.4 | -1.3 | 1.3 | 1.3 | 1.3 |
| Intermittent access intake escalation | 1.5 | 1.5 | 2.0 | 1.1 | 1.1 | -1.3 | -0.7 | -1.2 | -1.4 | 1.3 | 1.4 | 1.3 | -1.2 | -1.3 | -1.2 |
| Intermittent access day 15 total locomotion | 1.5 | 1.6 | 2.2 | 1.3 | 1.3 | -1.4 | -0.8 | -1.2 | -1.5 | 1.4 | 1.5 | 1.4 | -1.3 | -0.9 | -1.3 |
| Progressive ratio test 1 inactive lever presses | 1.5 | 1.6 | 2.9 | 1.3 | 1.3 | -1.2 | -1.7 | -1.3 | -1.0 | 1.2 | 1.0 | 1.2 | -1.3 | -1.3 | -1.3 |
| Novel to familiar place preference ratio | 1.5 | 1.6 | 1.6 | 1.3 | 1.3 | -1.3 | -1.1 | -1.3 | -1.3 | 1.3 | 1.3 | 1.3 | -1.3 | -1.2 | -1.3 |
| Delay disc. indifference point, 2s delay | 1.5 | 1.6 | 1.8 | -1.3 | -1.3 | 1.3 | 1.1 | 1.3 | 1.3 | -1.3 | -1.3 | -1.3 | 1.3 | 1.3 | 1.3 |
| Latency to leave start box in cocaine runway, F | 1.5 | 1.6 | 2.5 | -1.2 | -1.2 | 1.3 | 1.1 | 1.2 | 1.2 | -1.3 | -1.2 | -1.3 | 1.3 | 1.6 | 1.3 |
| Water consumed over 24 hours | 1.4 | 1.6 | 1.9 | -1.3 | -1.3 | 1.3 | 1.2 | 1.3 | 1.2 | -1.3 | -1.2 | -1.3 | 1.3 | 1.4 | 1.3 |
| Locomotor activity | 1.4 | 2.2 | 2.4 | -1.5 | -1.5 | 1.5 | 1.4 | 1.5 | 1.5 | -1.4 | -1.5 | -1.4 | 1.5 | 1.6 | 1.5 |
| Reaction time premature initiation rate | 1.4 | 1.9 | 2.4 | -1.3 | -1.3 | 1.5 | 0.8 | 1.4 | 1.5 | -1.5 | -1.5 | -1.5 | 1.4 | 1.4 | 1.4 |
| Incentive Sensitization - Breakpoint | 1.4 | 1.4 | 1.6 | 1.2 | 1.2 | -1.2 | -0.9 | -1.2 | -1.3 | 1.2 | 1.3 | 1.2 | -1.2 | -1.0 | -1.2 |
| Total zone transitions, hab. session 2 | 1.4 | 1.8 | 2.0 | -1.3 | -1.3 | 1.4 | 1.0 | 1.4 | 1.4 | -1.4 | -1.4 | -1.4 | 1.4 | 1.3 | 1.4 |
| Bone: apparent density | 1.4 | 2.4 | 2.7 | 1.5 | 1.5 | -1.7 | -1.2 | -1.6 | -1.6 | 1.7 | 1.6 | 1.7 | -1.6 | -1.3 | -1.6 |
| Bone: cortical porosity | 1.4 | 1.5 | 1.7 | -1.3 | -1.3 | 1.2 | 1.2 | 1.2 | 1.2 | -1.2 | -1.2 | -1.2 | 1.2 | 1.3 | 1.2 |
| Std. dev. time between licks in bursts | 1.3 | 1.6 | 1.7 | 1.3 | 1.3 | -1.3 | -1.3 | -1.3 | -1.2 | 1.3 | 1.2 | 1.3 | -1.3 | -1.1 | -1.3 |
| Light reinforcement 2 | 1.3 | 1.7 | 3.3 | 1.4 | 1.4 | -1.2 | -1.8 | -1.4 | -1.1 | 1.2 | 1.1 | 1.2 | -1.3 | -1.1 | -1.3 |
| Intermittent access standard deviation | 1.3 | 1.4 | 1.9 | 1.1 | 1.1 | -1.2 | -0.7 | -1.1 | -1.4 | 1.2 | 1.4 | 1.2 | -1.2 | -1.1 | -1.2 |
| Time in novel zone, hab. session 1 | 1.3 | 1.3 | 1.4 | -1.1 | -1.1 | 1.2 | 0.9 | 1.1 | 1.2 | -1.2 | -1.2 | -1.2 | 1.1 | 1.2 | 1.1 |
| Bone: trabecular tissue density | 1.3 | 1.9 | 2.1 | -1.4 | -1.4 | 1.4 | 1.0 | 1.4 | 1.4 | -1.4 | -1.4 | -1.4 | 1.4 | 1.3 | 1.4 |
| Food seeking constrained by brief footshock | 1.3 | 1.6 | 1.7 | -1.3 | -1.3 | 1.3 | 1.0 | 1.3 | 1.3 | -1.3 | -1.3 | -1.3 | 1.3 | 1.0 | 1.3 |
| Latency to leave start box in cocaine runway, M | 1.3 | 1.2 | 1.3 | 1.1 | 1.1 | -1.1 | -1.0 | -1.1 | -1.1 | 1.1 | 1.1 | 1.1 | -1.1 | -1.1 | -1.1 |
| Tibia length | 1.2 | 3.3 | 3.6 | 1.8 | 1.8 | -1.9 | -1.5 | -1.8 | -1.9 | 1.9 | 1.9 | 1.9 | -1.8 | -1.5 | -1.8 |
| Novelty place preference | 1.2 | 1.2 | 1.3 | 1.1 | 1.1 | -1.1 | -1.0 | -1.1 | -1.1 | 1.1 | 1.1 | 1.1 | -1.1 | -1.1 | -1.1 |
| Bone: trabecular thickness | 1.2 | 1.4 | 1.5 | 1.2 | 1.2 | -1.2 | -1.2 | -1.2 | -1.2 | 1.2 | 1.2 | 1.2 | -1.2 | -1.0 | -1.2 |
| Seeking ratio, delayed vs. immediate footshock | 1.2 | 1.3 | 1.7 | 1.0 | 1.0 | -1.3 | -0.6 | -1.1 | -1.3 | 1.3 | 1.3 | 1.3 | -1.1 | -1.3 | -1.1 |
| Mg content in liver | 1.2 | 1.3 | 1.5 | 1.1 | 1.1 | -1.1 | -1.2 | -1.1 | -1.1 | 1.1 | 1.1 | 1.1 | -1.1 | -1.1 | -1.1 |
| Social responses | 1.1 | 1.4 | 1.9 | 1.2 | 1.2 | -1.2 | -1.0 | -1.2 | -1.2 | 1.2 | 1.2 | 1.2 | -1.2 | -1.4 | -1.2 |
| Degree of sensitization stereotypy | 1.1 | 1.2 | 1.6 | -1.2 | -1.2 | 1.0 | 1.3 | 1.1 | 1.0 | -1.0 | -1.0 | -1.0 | 1.1 | 1.2 | 1.1 |
| Distance traveled before self-admin | 1.1 | 1.1 | 1.6 | -1.1 | -1.1 | 1.1 | 0.8 | 1.0 | 1.2 | -1.1 | -1.2 | -1.1 | 1.0 | 1.3 | 1.0 |
| Vertical activity count, locomotor time 1 | 1.1 | 1.2 | 1.2 | 1.1 | 1.1 | -1.1 | -1.0 | -1.1 | -1.1 | 1.1 | 1.1 | 1.1 | -1.1 | -1.0 | -1.1 |
| Conditioned locomotion | 1.0 | 1.2 | 1.4 | 1.1 | 1.1 | -1.1 | -0.9 | -1.1 | -1.2 | 1.1 | 1.2 | 1.1 | -1.1 | -0.9 | -1.1 |
| Intermittent access day 15 total infusions | 1.0 | 1.1 | 1.3 | 1.0 | 1.0 | -1.1 | -0.9 | -1.1 | -1.1 | 1.1 | 1.1 | 1.1 | -1.1 | -1.1 | -1.1 |
| Incentive Sensitization - Responses | 1.0 | 1.0 | 1.2 | 1.0 | 1.0 | -1.0 | -0.7 | -1.0 | -1.1 | 1.0 | 1.1 | 1.0 | -1.0 | -0.8 | -1.0 |
| Zn content in liver | 1.0 | 1.1 | 1.2 | -1.0 | -1.0 | 1.1 | 0.7 | 1.0 | 1.1 | -1.1 | -1.1 | -1.1 | 1.0 | 1.1 | 1.0 |
| Tail length | 0.9 | 2.6 | 2.7 | 1.6 | 1.6 | -1.7 | -1.3 | -1.6 | -1.7 | 1.7 | 1.7 | 1.7 | -1.6 | -1.5 | -1.6 |
| Soleus weight | 0.9 | 2.6 | 3.1 | -1.7 | -1.7 | 1.6 | 1.8 | 1.7 | 1.5 | -1.6 | -1.5 | -1.6 | 1.7 | 1.3 | 1.7 |
| Condit. Reinf. active responses | 0.9 | 1.2 | 1.5 | 1.1 | 1.1 | -1.1 | -0.8 | -1.1 | -1.2 | 1.1 | 1.2 | 1.1 | -1.1 | -1.2 | -1.1 |
| Baseline Anxiety | 0.9 | 0.9 | 1.5 | 0.9 | 0.9 | -1.0 | -0.6 | -0.9 | -1.1 | 1.0 | 1.1 | 1.0 | -0.9 | -1.2 | -0.9 |
| Pavlov. Cond. change in total contacts | 0.9 | 1.0 | 1.0 | -1.0 | -1.0 | 1.0 | 0.9 | 1.0 | 1.0 | -1.0 | -1.0 | -1.0 | 1.0 | 1.0 | 1.0 |
| Time to tail flick, test, before self-admin | 0.9 | 0.8 | 1.5 | 1.0 | 1.0 | -0.9 | -1.2 | -1.0 | -0.9 | 0.9 | 0.9 | 0.9 | -1.0 | -0.6 | -1.0 |
| Rest time, locomotor task time 2 | 0.9 | 1.1 | 1.2 | -1.1 | -1.1 | 1.1 | 0.8 | 1.0 | 1.1 | -1.0 | -1.1 | -1.0 | 1.0 | 1.0 | 1.0 |
| Seeking ratio, punishment vs. effort | 0.9 | 1.1 | 1.2 | -1.1 | -1.1 | 1.0 | 1.1 | 1.1 | 1.0 | -1.0 | -1.0 | -1.0 | 1.1 | 1.1 | 1.1 |
| Se content in liver | 0.9 | 1.1 | 1.1 | 1.0 | 1.0 | -1.1 | -1.0 | -1.1 | -1.0 | 1.1 | 1.0 | 1.1 | -1.1 | -1.0 | -1.1 |
| Short access total locomotion | 0.8 | 0.8 | 1.2 | 0.9 | 0.9 | -0.8 | -1.1 | -0.9 | -0.7 | 0.8 | 0.7 | 0.8 | -0.9 | -1.1 | -0.9 |
| Context. condit. distance diff. score | 0.8 | 1.0 | 1.1 | 1.0 | 1.0 | -1.0 | -0.9 | -1.0 | -1.0 | 1.0 | 1.0 | 1.0 | -1.0 | -1.0 | -1.0 |
| Time to tail flick, vehicle, before self-admin | 0.8 | 0.8 | 1.4 | 0.9 | 0.9 | -0.8 | -1.2 | -1.0 | -0.8 | 0.8 | 0.8 | 0.8 | -0.9 | -0.7 | -0.9 |
| Fecal boli incidents, locomotor time 1 | 0.8 | 0.9 | 1.0 | -1.0 | -1.0 | 1.0 | 0.9 | 1.0 | 0.9 | -1.0 | -0.9 | -1.0 | 1.0 | 0.7 | 1.0 |
| Time >=10cm from walls, locomotor time 1 | 0.8 | 0.8 | 1.5 | 1.0 | 1.0 | -0.8 | -1.2 | -0.9 | -0.7 | 0.8 | 0.7 | 0.8 | -0.9 | -1.0 | -0.9 |
| BMI without tail | 0.7 | 1.4 | 1.6 | 1.2 | 1.2 | -1.2 | -0.9 | -1.2 | -1.3 | 1.2 | 1.3 | 1.2 | -1.2 | -1.0 | -1.2 |
| Liver weight, right | 0.7 | 1.2 | 1.2 | -1.1 | -1.1 | 1.1 | 1.0 | 1.1 | 1.1 | -1.1 | -1.1 | -1.1 | 1.1 | 1.0 | 1.1 |
| Delay discounting total patch changes 12 sec | 0.7 | 1.0 | 1.5 | 1.1 | 1.1 | -0.9 | -1.0 | -1.0 | -1.0 | 0.9 | 1.0 | 0.9 | -1.0 | -1.2 | -1.0 |
| Delay discounting time to switch 0 sec | 0.7 | 1.1 | 1.8 | 1.1 | 1.1 | -1.0 | -1.3 | -1.1 | -0.9 | 1.0 | 0.9 | 1.0 | -1.1 | -1.0 | -1.1 |
| Delay discounting water rate 12 sec | 0.7 | 1.0 | 2.1 | -1.1 | -1.1 | 0.8 | 1.4 | 1.0 | 0.8 | -0.8 | -0.8 | -0.8 | 1.0 | 1.4 | 1.0 |
| Stereotopy head waving bouts, day 3 | 0.7 | 0.8 | 1.0 | -0.9 | -0.9 | 1.0 | 0.7 | 0.9 | 1.0 | -1.0 | -1.0 | -1.0 | 0.9 | 0.9 | 0.9 |
| Incentive salience index mean | 0.7 | 0.9 | 1.1 | -0.9 | -0.9 | 1.1 | 0.5 | 0.9 | 1.1 | -1.1 | -1.1 | -1.1 | 1.0 | 0.6 | 1.0 |
| Time in novel zone, hab. session 2 | 0.7 | 0.7 | 0.8 | 0.9 | 0.9 | -0.8 | -0.8 | -0.9 | -0.8 | 0.8 | 0.8 | 0.8 | -0.9 | -0.8 | -0.9 |
| Bone volume | 0.7 | 1.2 | 1.4 | 1.1 | 1.1 | -1.2 | -0.9 | -1.1 | -1.2 | 1.2 | 1.2 | 1.2 | -1.1 | -0.8 | -1.1 |
| Na content in liver | 0.7 | 0.7 | 0.8 | -0.8 | -0.8 | 0.9 | 0.5 | 0.8 | 0.9 | -0.9 | -0.9 | -0.9 | 0.8 | 0.9 | 0.8 |
| Condit. Reinf. lever reinforcers received | 0.6 | 0.8 | 1.0 | 0.9 | 0.9 | -0.9 | -0.6 | -0.9 | -1.0 | 0.9 | 1.0 | 0.9 | -0.9 | -1.0 | -0.9 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.6 | 0.7 | 0.8 | -0.9 | -0.9 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 | -0.9 | -0.9 | 0.9 | 0.8 | 0.9 |
| Short access day 10 total locomotion | 0.6 | 0.7 | 1.3 | 0.8 | 0.8 | -0.7 | -1.0 | -0.8 | -0.7 | 0.7 | 0.7 | 0.7 | -0.8 | -1.1 | -0.8 |
| Locomotion distance, session 8 | 0.6 | 0.9 | 1.0 | 1.0 | 1.0 | -0.9 | -0.9 | -1.0 | -1.0 | 0.9 | 1.0 | 0.9 | -1.0 | -1.0 | -1.0 |
| Time in novel zone, NPP test | 0.6 | 0.6 | 0.6 | 0.8 | 0.8 | -0.8 | -0.7 | -0.8 | -0.8 | 0.8 | 0.8 | 0.8 | -0.8 | -0.7 | -0.8 |
| Bone surface | 0.6 | 1.0 | 1.2 | 1.0 | 1.0 | -1.1 | -0.7 | -1.0 | -1.1 | 1.1 | 1.1 | 1.1 | -1.0 | -0.8 | -1.0 |
| Bone: cortical porosity | 0.6 | 0.6 | 0.8 | -0.8 | -0.8 | 0.8 | 0.8 | 0.8 | 0.7 | -0.8 | -0.7 | -0.8 | 0.8 | 0.9 | 0.8 |
| Bone: stiffness | 0.6 | 0.9 | 1.6 | -1.0 | -1.0 | 0.9 | 0.9 | 0.9 | 0.9 | -0.9 | -0.9 | -0.9 | 0.9 | 1.3 | 0.9 |
| Time in closed arm after self-admin | 0.6 | 0.6 | 0.8 | -0.8 | -0.8 | 0.7 | 0.9 | 0.8 | 0.8 | -0.7 | -0.8 | -0.7 | 0.8 | 0.6 | 0.8 |
| Ambulatory time before self-admin | 0.6 | 0.7 | 0.9 | -0.8 | -0.8 | 0.9 | 0.5 | 0.8 | 0.9 | -0.9 | -0.9 | -0.9 | 0.8 | 1.0 | 0.8 |
| Delay discount hyperbolic model param | 0.6 | 0.6 | 0.8 | 0.7 | 0.7 | -0.8 | -0.6 | -0.8 | -0.9 | 0.8 | 0.9 | 0.8 | -0.8 | -0.8 | -0.8 |
| Locomotion in novel chamber post-restriction | 0.6 | 0.7 | 0.9 | -0.9 | -0.9 | 0.8 | 0.9 | 0.9 | 0.8 | -0.8 | -0.8 | -0.8 | 0.9 | 0.7 | 0.9 |
| Latency to leave start box in cocaine runway | 0.6 | 0.6 | 1.0 | -0.8 | -0.8 | 0.8 | 0.7 | 0.8 | 0.8 | -0.8 | -0.8 | -0.8 | 0.8 | 1.0 | 0.8 |
| K content in liver | 0.6 | 0.6 | 0.8 | 0.8 | 0.8 | -0.7 | -0.9 | -0.8 | -0.7 | 0.7 | 0.7 | 0.7 | -0.8 | -0.7 | -0.8 |
| Intraocular pressure | 0.5 | 0.8 | 1.2 | 0.9 | 0.9 | -0.7 | -1.1 | -0.9 | -0.8 | 0.7 | 0.8 | 0.7 | -0.9 | -1.1 | -0.9 |
| Indifference point AUC | 0.5 | 0.6 | 0.8 | -0.7 | -0.7 | 0.9 | 0.6 | 0.8 | 0.8 | -0.9 | -0.8 | -0.9 | 0.8 | 0.7 | 0.8 |
| Reaction time number correct | 0.5 | 0.7 | 1.4 | -0.9 | -0.9 | 0.8 | 1.2 | 0.9 | 0.7 | -0.8 | -0.7 | -0.8 | 0.9 | 0.8 | 0.9 |
| Reaction time trials correct on left | 0.5 | 0.7 | 1.4 | -0.9 | -0.9 | 0.8 | 1.2 | 0.9 | 0.7 | -0.8 | -0.7 | -0.8 | 0.9 | 0.8 | 0.9 |
| Pavlov. Cond. index score | 0.5 | 0.6 | 0.6 | -0.8 | -0.8 | 0.8 | 0.7 | 0.8 | 0.8 | -0.8 | -0.8 | -0.8 | 0.8 | 0.8 | 0.8 |
| Intermittent access intake escalation 2 | 0.5 | 0.5 | 1.3 | 0.6 | 0.6 | -0.7 | -0.2 | -0.6 | -0.9 | 0.7 | 0.9 | 0.7 | -0.6 | -1.1 | -0.6 |
| Intermitt. access escalation Index | 0.5 | 0.5 | 0.8 | -0.6 | -0.6 | 0.7 | 0.3 | 0.6 | 0.9 | -0.7 | -0.9 | -0.7 | 0.7 | 0.4 | 0.7 |
| Intermittent access total locomotion | 0.5 | 0.6 | 0.7 | 0.7 | 0.7 | -0.8 | -0.6 | -0.7 | -0.8 | 0.8 | 0.8 | 0.8 | -0.7 | -0.7 | -0.7 |
| Post-drug Anxiety | 0.5 | 0.6 | 1.1 | 0.7 | 0.7 | -0.7 | -0.6 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -1.0 | -0.7 |
| Short access day 1 total inactive lever presses | 0.5 | 0.5 | 0.9 | 0.8 | 0.8 | -0.7 | -0.9 | -0.8 | -0.6 | 0.7 | 0.6 | 0.7 | -0.8 | -0.7 | -0.8 |
| Condit. Reinf. active minus inactive responses | 0.5 | 0.5 | 0.7 | -0.7 | -0.7 | 0.8 | 0.3 | 0.7 | 0.9 | -0.8 | -0.9 | -0.8 | 0.7 | 0.4 | 0.7 |
| Locomotion velocity, hab. session 2 | 0.5 | 0.7 | 0.9 | -0.8 | -0.8 | 0.9 | 0.6 | 0.9 | 0.9 | -0.9 | -0.9 | -0.9 | 0.9 | 0.7 | 0.9 |
| Bone: elastic displacement | 0.5 | 0.6 | 0.6 | 0.8 | 0.8 | -0.7 | -0.8 | -0.8 | -0.7 | 0.7 | 0.7 | 0.7 | -0.8 | -0.8 | -0.8 |
| Cu content in liver | 0.5 | 0.6 | 0.7 | -0.8 | -0.8 | 0.9 | 0.5 | 0.8 | 0.9 | -0.9 | -0.9 | -0.9 | 0.8 | 0.8 | 0.8 |
| BMI with tail | 0.4 | 1.4 | 1.7 | -1.2 | -1.2 | 1.1 | 1.3 | 1.2 | 1.1 | -1.1 | -1.1 | -1.1 | 1.2 | 1.3 | 1.2 |
| Body weight | 0.4 | 1.7 | 1.7 | -1.3 | -1.3 | 1.3 | 1.3 | 1.3 | 1.3 | -1.3 | -1.3 | -1.3 | 1.3 | 1.3 | 1.3 |
| Times rat made contact with spout | 0.4 | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | -0.6 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -0.4 | -0.7 |
| Mean num. licks in bursts | 0.4 | 0.4 | 0.7 | 0.7 | 0.7 | -0.6 | -0.8 | -0.7 | -0.6 | 0.6 | 0.6 | 0.6 | -0.7 | -0.5 | -0.7 |
| Reaction time trials on left | 0.4 | 0.5 | 1.1 | -0.8 | -0.8 | 0.6 | 1.1 | 0.8 | 0.6 | -0.7 | -0.6 | -0.7 | 0.8 | 0.6 | 0.8 |
| Reaction time mean AUC | 0.4 | 0.5 | 0.7 | -0.6 | -0.6 | 0.8 | 0.2 | 0.7 | 0.8 | -0.8 | -0.8 | -0.8 | 0.7 | 0.6 | 0.7 |
| Reaction time trials completed | 0.4 | 0.5 | 1.1 | -0.8 | -0.8 | 0.6 | 1.1 | 0.8 | 0.6 | -0.7 | -0.6 | -0.7 | 0.8 | 0.6 | 0.8 |
| Social time | 0.4 | 0.5 | 0.6 | 0.6 | 0.6 | -0.8 | -0.4 | -0.7 | -0.7 | 0.8 | 0.7 | 0.8 | -0.7 | -0.7 | -0.7 |
| Pavlov. Cond. lever contacts | 0.4 | 0.5 | 0.5 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 |
| Pavlov. Cond. response bias | 0.4 | 0.6 | 0.6 | -0.8 | -0.8 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 | -0.8 | -0.8 | 0.8 | 0.8 | 0.8 |
| Intermittent access total infusions | 0.4 | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -0.6 | -0.7 |
| Lifetime Intake | 0.4 | 0.5 | 0.7 | 0.7 | 0.7 | -0.7 | -0.8 | -0.7 | -0.6 | 0.7 | 0.6 | 0.7 | -0.7 | -0.5 | -0.7 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 0.6 | 0.6 | 0.6 | -0.6 | -0.7 | -0.6 | -0.5 | 0.6 | 0.5 | 0.6 | -0.6 | -0.8 | -0.6 |
| Locomotion velocity, session 3 | 0.4 | 0.5 | 0.6 | -0.7 | -0.7 | 0.8 | 0.6 | 0.7 | 0.7 | -0.8 | -0.7 | -0.8 | 0.7 | 0.6 | 0.7 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -0.5 | -0.7 |
| Active lever presses in extinction session 6 | 0.4 | 0.3 | 1.6 | 0.7 | 0.7 | -0.3 | -1.2 | -0.6 | -0.4 | 0.3 | 0.4 | 0.3 | -0.5 | -0.4 | -0.5 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.3 | 0.4 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | 0.7 | -0.6 | -0.7 | -0.6 | 0.6 | 0.3 | 0.6 |
| Sr content in liver | 0.4 | 0.4 | 0.6 | 0.7 | 0.7 | -0.6 | -0.8 | -0.7 | -0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.7 | -0.6 |
| Delay discounting total patch changes 6 sec | 0.3 | 0.5 | 0.8 | 0.8 | 0.8 | -0.6 | -0.9 | -0.7 | -0.7 | 0.6 | 0.7 | 0.6 | -0.7 | -0.8 | -0.7 |
| Delay discounting water rate 0 sec | 0.3 | 0.5 | 1.0 | -0.8 | -0.8 | 0.6 | 1.0 | 0.7 | 0.6 | -0.6 | -0.6 | -0.6 | 0.7 | 0.7 | 0.7 |
| Reaction time trials AUC | 0.3 | 0.5 | 1.1 | -0.7 | -0.7 | 0.6 | 1.0 | 0.7 | 0.5 | -0.6 | -0.5 | -0.6 | 0.7 | 0.6 | 0.7 |
| Condit. Reinf. active minus inactive responses | 0.3 | 0.4 | 0.4 | 0.6 | 0.6 | -0.6 | -0.4 | -0.6 | -0.7 | 0.6 | 0.7 | 0.6 | -0.6 | -0.7 | -0.6 |
| Pavlov. Cond. lever latency | 0.3 | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | -0.7 | -0.7 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | -0.7 | -0.7 |
| Pavlov. Cond. latency score | 0.3 | 0.4 | 0.4 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.4 | 0.6 | 0.6 | -0.6 | -0.7 | -0.6 | -0.5 | 0.6 | 0.5 | 0.6 | -0.6 | -0.5 | -0.6 |
| Progressive ratio test 2 inactive lever presses | 0.3 | 0.4 | 0.6 | 0.7 | 0.7 | -0.6 | -0.8 | -0.7 | -0.5 | 0.6 | 0.5 | 0.6 | -0.7 | -0.4 | -0.7 |
| One hour access (0.3 mA shock) | 0.3 | 0.3 | 0.5 | 0.5 | 0.5 | -0.6 | -0.3 | -0.6 | -0.7 | 0.6 | 0.7 | 0.6 | -0.6 | -0.5 | -0.6 |
| Bone: elastic work | 0.3 | 0.3 | 0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | -0.5 | 0.6 | 0.5 | 0.6 | -0.6 | -0.8 | -0.6 |
| Bone: maximum diameter | 0.3 | 0.6 | 1.1 | -0.8 | -0.8 | 0.7 | 0.8 | 0.8 | 0.7 | -0.7 | -0.7 | -0.7 | 0.8 | 1.1 | 0.8 |
| Bone: maximum force | 0.3 | 0.4 | 0.8 | -0.7 | -0.7 | 0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.9 | 0.6 |
| Delta time to tail flick, test, before/after SA | 0.3 | 0.3 | 0.7 | 0.5 | 0.5 | -0.6 | -0.1 | -0.5 | -0.5 | 0.6 | 0.5 | 0.6 | -0.5 | -0.8 | -0.5 |
| Total heroin consumption | 0.3 | 0.4 | 0.4 | -0.6 | -0.6 | 0.6 | 0.3 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.7 | 0.6 |
| Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 0.5 | 0.6 | 0.6 | -0.5 | -0.7 | -0.6 | -0.6 | 0.5 | 0.6 | 0.5 | -0.6 | -0.5 | -0.6 |
| Time >=10cm from walls, locomotor time 2 | 0.3 | 0.4 | 0.4 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.5 | 0.6 |
| Vertical activity count, locomotor time 2 | 0.3 | 0.4 | 0.5 | 0.7 | 0.7 | -0.6 | -0.5 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.3 | -0.6 |
| Cd content in liver | 0.3 | 0.3 | 0.7 | 0.6 | 0.6 | -0.5 | -0.8 | -0.6 | -0.4 | 0.5 | 0.4 | 0.5 | -0.6 | -0.5 | -0.6 |
| Rb content in liver | 0.3 | 0.3 | 0.4 | 0.5 | 0.5 | -0.6 | -0.3 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 |
| Left kidney weight | 0.2 | 0.7 | 1.8 | -0.9 | -0.9 | 0.6 | 1.4 | 0.8 | 0.6 | -0.6 | -0.6 | -0.6 | 0.8 | 0.9 | 0.8 |
| Retroperitoneal fat weight | 0.2 | 0.8 | 1.1 | 0.8 | 0.8 | -1.0 | -0.2 | -0.8 | -1.0 | 1.0 | 1.0 | 1.0 | -0.8 | -0.9 | -0.8 |
| Food consumed during 24 hour testing period | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | -0.6 | -0.2 | -0.5 | -0.6 | 0.6 | 0.6 | 0.6 | -0.5 | -0.6 | -0.5 |
| Locomotor testing rearing | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | -0.6 | -0.5 | -0.6 | -0.6 | 0.6 | 0.6 | 0.6 | -0.6 | -0.5 | -0.6 |
| Reaction time mean | 0.2 | 0.3 | 0.4 | -0.4 | -0.4 | 0.6 | 0.0 | 0.5 | 0.7 | -0.6 | -0.7 | -0.6 | 0.5 | 0.5 | 0.5 |
| Std. dev. reaction times | 0.2 | 0.2 | 0.4 | -0.4 | -0.4 | 0.6 | 0.0 | 0.5 | 0.6 | -0.6 | -0.6 | -0.6 | 0.5 | 0.1 | 0.5 |
| Cocaine response after cond. corrected | 0.2 | 0.3 | 0.3 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 | 0.5 | -0.5 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 |
| Cocaine response after cond. not corrected | 0.2 | 0.2 | 0.2 | -0.4 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Saline control response | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | -0.5 | -0.6 | -0.5 | -0.4 | 0.5 | 0.4 | 0.5 | -0.5 | -0.5 | -0.5 |
| Intermittent access terminal intake (last 3 days) | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 | -0.5 | -0.3 | -0.5 | -0.6 | 0.5 | 0.6 | 0.5 | -0.5 | -0.5 | -0.5 |
| Cocaine induced anxiety | 0.2 | 0.2 | 0.3 | -0.4 | -0.4 | 0.4 | 0.1 | 0.4 | 0.5 | -0.4 | -0.5 | -0.4 | 0.4 | 0.5 | 0.4 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | 0.5 | 0.2 | 0.4 | 0.6 | -0.5 | -0.6 | -0.5 | 0.4 | 0.4 | 0.4 |
| Progressive ratio test 2 active lever presses | 0.2 | 0.2 | 0.2 | 0.5 | 0.5 | -0.5 | -0.4 | -0.5 | -0.4 | 0.5 | 0.4 | 0.5 | -0.5 | -0.3 | -0.5 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.3 | 0.3 | 0.5 | 0.5 | -0.5 | -0.5 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 | -0.5 | -0.3 | -0.5 |
| Short access total infusions | 0.2 | 0.2 | 0.6 | 0.5 | 0.5 | -0.4 | -0.8 | -0.5 | -0.3 | 0.4 | 0.3 | 0.4 | -0.5 | -0.1 | -0.5 |
| Short access day 1 locomotion | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | 0.5 | 0.3 | 0.4 | 0.5 | -0.5 | -0.5 | -0.5 | 0.4 | 0.2 | 0.4 |
| Locomotion velocity, session 1 | 0.2 | 0.2 | 0.3 | -0.4 | -0.4 | 0.4 | 0.2 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | 0.6 | 0.3 | 0.6 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.3 | 0.6 |
| Total zone transitions, hab. session 1 | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | 0.6 | 0.2 | 0.5 | 0.6 | -0.6 | -0.6 | -0.6 | 0.5 | 0.3 | 0.5 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | 0.6 | 0.3 | 0.5 | 0.6 | -0.6 | -0.6 | -0.6 | 0.6 | 0.4 | 0.6 |
| Total zone transitions, NPP test | 0.2 | 0.2 | 0.5 | 0.5 | 0.5 | -0.4 | -0.7 | -0.5 | -0.4 | 0.4 | 0.4 | 0.4 | -0.5 | -0.7 | -0.5 |
| Bone: minimum diameter | 0.2 | 0.3 | 0.9 | -0.6 | -0.6 | 0.4 | 0.6 | 0.5 | 0.4 | -0.4 | -0.4 | -0.4 | 0.5 | 1.0 | 0.5 |
| Time in open arm before self-admin | 0.2 | 0.2 | 0.4 | -0.4 | -0.4 | 0.5 | -0.1 | 0.3 | 0.6 | -0.5 | -0.6 | -0.5 | 0.4 | 0.7 | 0.4 |
| Delay disc. indifference point, 16s delay | 0.2 | 0.2 | 0.3 | 0.5 | 0.5 | -0.4 | -0.6 | -0.5 | -0.4 | 0.4 | 0.4 | 0.4 | -0.5 | -0.4 | -0.5 |
| Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 0.3 | -0.4 | -0.4 | 0.5 | 0.2 | 0.5 | 0.5 | -0.5 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 |
| Delay discount exponential model param | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 | -0.5 | -0.3 | -0.5 | -0.6 | 0.5 | 0.6 | 0.5 | -0.5 | -0.5 | -0.5 |
| Locomotion in novel chamber | 0.2 | 0.2 | 0.4 | 0.4 | 0.4 | -0.4 | -0.3 | -0.4 | -0.5 | 0.4 | 0.5 | 0.4 | -0.4 | -0.7 | -0.4 |
| Right kidney weight | 0.1 | 0.4 | 0.6 | 0.5 | 0.5 | -0.8 | -0.1 | -0.6 | -0.7 | 0.8 | 0.7 | 0.8 | -0.6 | -0.5 | -0.6 |
| Length with tail | 0.1 | 0.2 | 0.2 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 | 0.5 | -0.5 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 |
| Delay discounting water rate 24 sec | 0.1 | 0.1 | 0.7 | -0.4 | -0.4 | 0.1 | 0.8 | 0.3 | 0.1 | -0.1 | -0.1 | -0.1 | 0.3 | 0.6 | 0.3 |
| Reaction time mean minus median | 0.1 | 0.2 | 0.3 | -0.3 | -0.3 | 0.5 | 0.1 | 0.4 | 0.5 | -0.5 | -0.5 | -0.5 | 0.4 | 0.0 | 0.4 |
| Reaction time mean minus median AUC | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.5 | 0.0 | 0.4 | 0.5 | -0.5 | -0.5 | -0.5 | 0.4 | 0.1 | 0.4 |
| Median of all reaction times | 0.1 | 0.1 | 0.2 | -0.2 | -0.2 | 0.4 | -0.2 | 0.3 | 0.4 | -0.4 | -0.4 | -0.4 | 0.3 | 0.4 | 0.3 |
| Reaction time false alarm rate | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | -0.5 | -0.1 | -0.4 | -0.5 | 0.5 | 0.5 | 0.5 | -0.4 | -0.4 | -0.4 |
| Social response proportion | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.2 | 0.4 | 0.3 | 0.2 | -0.2 | -0.2 | -0.2 | 0.3 | 0.4 | 0.3 |
| Cocaine response before conditioning | 0.1 | 0.1 | 0.2 | 0.4 | 0.4 | -0.4 | -0.5 | -0.4 | -0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.3 | -0.4 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.2 | 0.3 | -0.4 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | -0.2 | -0.3 | -0.3 | 0.3 | 0.3 | 0.3 | -0.3 | -0.4 | -0.3 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | -0.2 | -0.3 | -0.3 | 0.3 | 0.3 | 0.3 | -0.3 | -0.3 | -0.3 |
| Intermitt. access day 1 inactive lever presses | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | -0.3 | -0.2 | -0.3 | -0.2 | 0.3 | 0.2 | 0.3 | -0.3 | -0.5 | -0.3 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.3 | -0.0 | 0.3 | 0.4 | -0.3 | -0.4 | -0.3 | 0.3 | 0.2 | 0.3 |
| Short access day 1 total infusions | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.4 | -0.1 | 0.3 | 0.5 | -0.4 | -0.5 | -0.4 | 0.3 | 0.3 | 0.3 |
| Number of responses in last shaping day | 0.1 | 0.1 | 0.3 | -0.0 | -0.0 | 0.2 | -0.4 | 0.0 | 0.3 | -0.2 | -0.3 | -0.2 | 0.1 | 0.5 | 0.1 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.3 | 0.4 | 0.4 | -0.3 | -0.6 | -0.4 | -0.3 | 0.3 | 0.3 | 0.3 | -0.3 | -0.5 | -0.3 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | -0.3 | 0.2 | 0.3 | 0.2 | -0.2 | -0.4 | -0.2 |
| Pavlov. Cond. intertrial magazine entries | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | -0.2 | -0.4 | -0.3 | -0.2 | 0.2 | 0.2 | 0.2 | -0.3 | -0.3 | -0.3 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.3 | 0.4 |
| Pavlov. Cond. response bias | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | 0.3 | 0.4 | 0.4 | 0.3 | -0.3 | -0.3 | -0.3 | 0.4 | 0.2 | 0.4 |
| Bone: endosteal estimation | 0.1 | 0.3 | 0.7 | -0.6 | -0.6 | 0.4 | 0.6 | 0.5 | 0.4 | -0.4 | -0.4 | -0.4 | 0.5 | 0.9 | 0.5 |
| Bone: endosteal perimeter | 0.1 | 0.2 | 0.4 | -0.4 | -0.4 | 0.3 | 0.5 | 0.4 | 0.3 | -0.3 | -0.3 | -0.3 | 0.4 | 0.7 | 0.4 |
| Bone: final force | 0.1 | 0.2 | 0.3 | -0.5 | -0.5 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Bone: final moment | 0.1 | 0.2 | 0.3 | -0.4 | -0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.4 |
| Bone: marrow area | 0.1 | 0.2 | 0.5 | -0.4 | -0.4 | 0.3 | 0.5 | 0.4 | 0.3 | -0.3 | -0.3 | -0.3 | 0.4 | 0.7 | 0.4 |
| Bone: maximum moment | 0.1 | 0.2 | 0.6 | -0.5 | -0.5 | 0.5 | 0.4 | 0.5 | 0.5 | -0.5 | -0.5 | -0.5 | 0.5 | 0.8 | 0.5 |
| Bone: post-yield work | 0.1 | 0.2 | 0.2 | 0.4 | 0.4 | -0.5 | -0.4 | -0.5 | -0.5 | 0.5 | 0.5 | 0.5 | -0.5 | -0.1 | -0.5 |
| Bone: tissue strength | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.3 | -0.1 | -0.3 | -0.4 | 0.3 | 0.4 | 0.3 | -0.3 | -0.4 | -0.3 |
| Breakpoint value in progressive ratio session | 0.1 | 0.1 | 0.2 | -0.2 | -0.2 | 0.4 | -0.2 | 0.2 | 0.3 | -0.4 | -0.3 | -0.4 | 0.2 | 0.5 | 0.2 |
| Delta time in open arm before/after self-admin | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | -0.3 | 0.0 | -0.2 | -0.4 | 0.3 | 0.4 | 0.3 | -0.2 | -0.4 | -0.2 |
| Time in open arm after self-admin | 0.1 | 0.1 | 0.1 | 0.4 | 0.4 | -0.3 | -0.3 | -0.3 | -0.4 | 0.3 | 0.4 | 0.3 | -0.3 | -0.3 | -0.3 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | -0.1 | -0.6 | -0.2 | -0.1 | 0.1 | 0.1 | 0.1 | -0.2 | 0.2 | -0.2 |
| Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.3 | 0.1 | 0.3 | 0.4 | -0.3 | -0.4 | -0.3 | 0.3 | 0.3 | 0.3 |
| Progressive ratio | 0.1 | 0.1 | 0.3 | 0.4 | 0.4 | -0.3 | -0.5 | -0.4 | -0.3 | 0.3 | 0.3 | 0.3 | -0.4 | -0.5 | -0.4 |
| Glucose | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.1 | -0.2 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.2 | -0.1 |
| Heart weight | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.0 | -0.1 | -0.1 | 0.2 | 0.1 | 0.2 | -0.2 | 0.1 | -0.2 |
| Number of licking bursts | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | 0.3 | 0.1 | 0.0 | -0.1 | -0.0 | -0.1 | 0.1 | 0.1 | 0.1 |
| Indifference point function ln k | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.0 | -0.1 | -0.2 | 0.2 | 0.2 | 0.2 | -0.1 | -0.0 | -0.1 |
| Indifference point function log k | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.0 | -0.1 | -0.2 | 0.2 | 0.2 | 0.2 | -0.1 | -0.0 | -0.1 |
| Delay discounting total patch changes 24 sec | 0.0 | 0.0 | 0.3 | 0.2 | 0.2 | 0.0 | -0.5 | -0.1 | -0.0 | -0.0 | 0.0 | -0.0 | -0.1 | -0.4 | -0.1 |
| Locomotor testing distance | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.0 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.0 | -0.1 |
| Reaction time num false alarms | 0.0 | 0.1 | 0.4 | -0.2 | -0.2 | 0.0 | 0.7 | 0.2 | -0.0 | -0.0 | 0.0 | -0.0 | 0.2 | 0.2 | 0.2 |
| Reaction time num false alarms AUC | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | -0.2 | 0.5 | -0.0 | -0.2 | 0.2 | 0.2 | 0.2 | -0.0 | -0.0 | -0.0 |
| Conditioned locomotion | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.4 | -0.2 |
| Pavlov. Cond. magazine entry number | 0.0 | 0.1 | 0.1 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | 0.2 | 0.3 | 0.2 |
| Intermitt. access day 15 inactive lever presses | 0.0 | 0.0 | 0.4 | 0.1 | 0.1 | 0.0 | -0.6 | -0.1 | 0.2 | -0.0 | -0.2 | -0.0 | -0.1 | 0.1 | -0.1 |
| Intermittent access day 1 total infusions | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | -0.1 | -0.4 | -0.2 | -0.1 | 0.1 | 0.1 | 0.1 | -0.2 | -0.0 | -0.2 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.1 | -0.4 | -0.2 | 0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.2 | -0.1 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | -0.1 | -0.4 | -0.2 | 0.0 | 0.1 | -0.0 | 0.1 | -0.2 | 0.2 | -0.2 |
| Compulsive drug intake | 0.0 | 0.0 | 0.2 | -0.1 | -0.1 | 0.0 | 0.5 | 0.1 | -0.1 | -0.0 | 0.1 | -0.0 | 0.1 | 0.1 | 0.1 |
| One hour access (shock baseline) | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.2 | -0.0 | 0.1 | -0.0 | -0.1 | -0.0 | -0.0 | -0.0 | -0.0 |
| Locomotion distance, session 1 | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.0 | -0.3 | -0.1 | -0.0 | 0.0 | 0.0 | 0.0 | -0.1 | -0.2 | -0.1 |
| Locomotion velocity, session 2 | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.2 | -0.1 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.2 |
| Locomotion distance, session 2 | 0.0 | 0.0 | 0.0 | 0.2 | 0.2 | -0.2 | -0.1 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 |
| Locomotion distance, session 3 | 0.0 | 0.0 | 0.2 | 0.2 | 0.2 | -0.1 | -0.2 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.4 | -0.1 |
| Locomotion velocity, session 8 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.2 | -0.1 |
| Condit. Reinf. active responses | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | 0.1 | -0.3 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 | 0.0 | -0.3 | 0.0 |
| Time in familiar zone, hab. session 1 | 0.0 | 0.0 | 0.0 | -0.2 | -0.2 | 0.1 | 0.2 | 0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | 0.0 | 0.1 |
| Total locomotion distance, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.1 | -0.3 | -0.0 | 0.1 | -0.1 | -0.1 | -0.1 | -0.0 | -0.2 | -0.0 |
| Pavlov. Cond. lever latency | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | 0.1 | -0.0 | 0.0 | 0.0 | -0.1 | -0.0 | -0.1 | 0.0 | 0.2 | 0.0 |
| Pavlov. Cond. index score | 0.0 | 0.1 | 0.1 | -0.2 | -0.2 | 0.2 | 0.3 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | 0.2 | 0.1 | 0.2 |
| Pavlov. Cond. latency score | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | -0.0 | 0.1 |
| Pavlov. Cond. lever contacts | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | -0.1 | -0.0 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.3 | -0.1 |
| Bone: cortical apparent density | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.2 | -0.3 | -0.2 | -0.1 | 0.2 | 0.1 | 0.2 | -0.2 | -0.3 | -0.2 |
| Bone: cortical area | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | -0.1 | 0.0 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.2 | -0.1 |
| Bone: cortical thickness | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | -0.1 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.1 | -0.2 |
| Bone: cortical thickness | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 |
| Bone: cortical tissue density | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.1 | -0.3 | -0.2 | -0.1 | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | -0.2 |
| Bone: periosteal estimation | 0.0 | 0.1 | 0.4 | -0.3 | -0.3 | 0.2 | 0.4 | 0.2 | 0.2 | -0.2 | -0.2 | -0.2 | 0.2 | 0.6 | 0.2 |
| Bone: periosteal perimeter | 0.0 | 0.0 | 0.2 | -0.2 | -0.2 | 0.0 | 0.3 | 0.1 | 0.0 | -0.0 | -0.0 | -0.0 | 0.1 | 0.4 | 0.1 |
| Area under the delay curve | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.2 | 0.0 | 0.2 | 0.3 | -0.2 | -0.3 | -0.2 | 0.2 | 0.2 | 0.2 |
| Delay disc. indifference point, 8s delay | 0.0 | 0.0 | 0.0 | 0.2 | 0.2 | -0.1 | -0.2 | -0.1 | -0.0 | 0.1 | 0.0 | 0.1 | -0.1 | -0.1 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.