Hub : Genes

Ppp2r5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000021025 0.2 0.08 0.0e+00 0.12 0.12 0.11 0.12 1.6e-13 1.0e-13 2.0e-12 1.2e-13
2 Adipose mRNA stability ENSRNOG00000021025 0.07 0.04 3.5e-06 0.04 0.03 0.02 0.04 1.0e-05 1.7e-04 6.6e-03 4.2e-05
3 Brain gene expression ENSRNOG00000021025 0.07 0.04 3.4e-05 0.05 0.04 0.05 0.05 3.2e-05 1.0e-04 4.2e-05 9.1e-06
4 NAcc gene expression ENSRNOG00000021025 0.06 0.03 9.5e-05 0.03 0.04 0.04 0.04 3.8e-03 5.8e-04 5.9e-04 4.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail2.37.416.1-1.9-2.6-4.0-1.7
BMI without tail1.83.77.0-1.7-1.9-2.6-1.2
Body weight3.515.020.8-3.4-3.9-4.6-3.5
Epididymis fat weight2.76.37.62.52.72.02.8
Glucose1.92.93.81.81.81.32.0
Heart weight2.43.43.81.61.91.91.9
Left kidney weight0.82.42.71.61.61.21.7
Right kidney weight0.41.31.91.41.20.91.0
Tail length1.23.74.9-2.2-1.8-1.4-2.1
Length with tail2.28.29.8-2.8-2.9-2.6-3.1
Length without tail1.83.95.0-1.7-2.0-1.9-2.2
Liver weight, left0.00.00.10.10.2-0.20.2
Liver weight, right0.20.30.7-0.5-0.2-0.8-0.2
Parametrial fat weight2.34.66.92.12.31.32.6
Retroperitoneal fat weight5.417.920.54.14.53.74.5
Intraocular pressure2.23.14.71.71.82.21.3
Extensor digitorum longus weight6.927.833.6-4.7-5.4-5.8-5.1
Soleus weight3.39.611.12.83.33.03.2
Tibialis anterior weight9.432.434.7-5.2-5.9-5.8-5.9
Tibia length0.10.40.6-0.1-0.6-0.8-0.8
Number of licking bursts0.00.10.1-0.2-0.3-0.2-0.3
Food consumed during 24 hour testing period0.10.10.30.30.20.6-0.1
Times rat made contact with spout0.70.81.0-0.9-1.0-0.7-0.9
Mean time between licks in bursts1.82.43.4-1.9-1.5-1.3-1.6
Mean num. licks in bursts0.00.00.0-0.10.00.10.1
Std. dev. time between licks in bursts0.40.41.0-1.0-0.4-0.2-0.7
Water consumed over 24 hours0.81.01.4-1.0-1.1-0.6-1.2
Indifference point 0 sec0.10.10.20.30.10.20.4
Indifference point AUC2.02.42.7-1.3-1.6-1.6-1.7
Indifference point function ln k4.36.07.01.92.62.62.6
Indifference point function log k4.36.07.01.92.62.62.6
Delay discounting total patch changes 0 sec0.00.00.0-0.1-0.10.10.1
Delay discounting total patch changes 12 sec3.34.35.0-1.8-2.2-2.2-2.0
Delay discounting total patch changes 18 sec0.20.30.6-0.3-0.5-0.8-0.3
Delay discounting total patch changes 24 sec2.12.73.0-1.6-1.7-1.5-1.7
Delay discounting total patch changes 6 sec1.01.51.8-1.1-1.3-1.3-1.0
Delay discounting time to switch 0 sec0.81.23.0-0.5-1.1-1.7-0.6
Delay discounting water rate 0 sec3.04.87.71.62.42.81.7
Delay discounting water rate 12 sec4.16.210.71.62.73.32.0
Delay discounting water rate 18 sec1.11.42.10.81.31.51.1
Delay discounting water rate 24 sec2.23.04.51.22.12.11.4
Delay discounting water rate 6 sec1.62.44.30.71.82.11.1
Locomotor activity0.60.91.50.41.21.20.7
Locomotor testing distance0.50.91.70.21.21.30.6
Locomotor testing rearing0.50.81.50.41.11.20.8
Light reinforcement 10.10.10.30.20.30.50.3
Light reinforcement 22.02.73.61.91.61.51.5
Reaction time number correct0.40.61.1-0.8-0.7-0.4-1.0
Reaction time mean minus median1.21.62.2-0.7-1.4-1.5-1.2
Reaction time mean minus median AUC0.70.91.1-0.7-1.1-0.9-1.1
Reaction time num false alarms0.10.10.4-0.6-0.30.1-0.1
Reaction time num false alarms AUC0.50.71.3-1.1-0.9-0.6-0.7
Reaction time trials correct on left0.40.61.1-0.8-0.7-0.4-1.0
Reaction time trials on left0.50.81.3-0.9-0.8-0.5-1.2
Reaction time mean0.20.20.40.70.30.50.4
Reaction time mean AUC0.20.30.60.80.40.50.5
Median of all reaction times0.40.60.90.90.60.80.7
Reaction time omissions0.70.91.4-0.7-1.1-0.7-1.2
Reaction time false alarm rate0.00.10.2-0.4-0.2-0.10.1
Reaction time premature initiation rate5.06.77.7-2.8-2.6-2.3-2.7
Reaction time premature initiations6.59.211.1-3.2-3.0-2.5-3.3
Std. dev. reaction times0.10.20.3-0.1-0.6-0.4-0.4
Reaction time trials completed0.50.81.3-0.9-0.8-0.5-1.2
Reaction time trials AUC0.40.61.0-0.8-0.7-0.4-1.0
Social response proportion0.50.50.7-0.6-0.9-0.7-0.7
Social responses0.30.40.5-0.7-0.7-0.4-0.7
Social time0.60.81.3-1.0-0.9-0.6-1.1
Conditioned locomotion1.72.02.4-1.4-1.5-1.3-1.6
Cocaine response after cond. corrected0.30.40.50.40.70.60.7
Cocaine response after cond. not corrected0.20.30.40.30.60.40.7
Cocaine response before conditioning0.20.20.4-0.3-0.5-0.6-0.4
Saline control response4.76.26.4-2.4-2.5-2.5-2.5
Condit. Reinf. active minus inactive responses0.60.71.11.00.90.50.8
Condit. Reinf. active-inactive response ratio2.12.23.11.81.51.01.6
Condit. Reinf. active responses0.00.10.20.40.20.00.2
Condit. Reinf. inactive responses0.60.70.8-0.9-0.9-0.7-0.8
Condit. Reinf. lever presses0.60.81.2-0.5-0.9-1.1-0.9
Condit. Reinf. lever reinforcers received0.00.00.00.2-0.1-0.2-0.1
Pavlov. Cond. lever latency0.10.10.30.00.20.50.3
Pavlov. Cond. magazine entry latency2.52.83.6-1.4-1.8-1.9-1.6
Pavlov. Cond. change in total contacts0.20.20.40.1-0.5-0.7-0.4
Pavlov. Cond. index score0.81.01.7-0.6-1.1-1.3-1.0
Pavlov. Cond. latency score0.60.81.4-0.5-0.9-1.2-0.8
Pavlov. Cond. lever contacts0.10.10.2-0.1-0.3-0.3-0.5
Pavlov. Cond. magazine entry number3.64.45.31.62.32.32.1
Pavlov. Cond. intertrial magazine entries1.01.31.41.01.21.11.1
Pavlov. Cond. lever-magazine prob. diff.1.21.52.3-0.8-1.3-1.5-1.2
Pavlov. Cond. response bias0.60.91.0-0.6-1.0-1.0-1.0
Conditioned reinforcement - actives0.80.81.31.10.80.80.7
Conditioned reinforcement - inactives8.69.810.33.23.23.13.0
Conditioned locomotion9.411.312.93.23.53.63.1
Intermittent access intake day 1-15 change1.41.41.81.21.21.40.9
Intermittent access intake escalation1.31.31.41.21.11.21.0
Intermittent access intake escalation 20.60.60.90.90.80.90.5
Intermitt. access day 1 inactive lever presses3.03.23.51.81.81.71.9
Intermitt. access day 15 inactive lever presses4.44.85.82.42.22.12.1
Intermitt. access escalation Index2.01.82.61.01.31.31.6
Intermittent access day 1 total infusions6.37.19.32.92.71.93.1
Intermittent access day 15 total infusions10.812.113.53.73.63.03.6
Intermittent access terminal intake (last 3 days)8.28.911.03.33.12.33.1
Intermittent access total infusions6.77.49.23.02.82.03.0
Intermittent access day 1 locomotion3.43.55.41.91.91.22.3
Intermittent access day 15 total locomotion7.17.68.52.92.82.32.9
Intermittent access total locomotion8.79.812.13.43.22.33.5
Intermittent access standard deviation1.92.02.21.51.41.51.3
Cocaine induced anxiety0.00.00.10.30.1-0.00.1
Post-drug Anxiety0.60.71.1-0.6-0.9-0.7-1.0
Baseline Anxiety2.52.63.0-1.6-1.7-1.4-1.7
Lifetime Intake5.25.97.52.62.51.72.7
Incentive Sensitization - Responses1.31.31.71.31.10.91.2
Incentive Sensitization - Breakpoint1.71.72.21.51.31.11.3
Progressive ratio test 1 active lever presses3.73.84.12.02.01.91.9
Progressive ratio test 1 breakpoint3.33.43.71.91.91.81.8
Progressive ratio test 1 inactive lever presses1.21.31.61.01.11.11.3
Progressive ratio test 2 active lever presses6.87.28.22.92.72.42.7
Progressive ratio test 2 breakpoint7.68.49.03.03.02.82.8
Progressive ratio test 2 inactive lever presses12.114.015.43.93.83.43.9
Total sessions with >9 infusions1.51.62.41.21.40.81.5
Short access day 1 total inactive lever presses4.14.55.02.02.22.12.1
Short access day 10 total inactive lever presses2.52.83.41.21.71.81.7
Short access day 1 total infusions3.03.24.61.81.71.32.1
Short access day 10 total infusions2.02.23.81.71.40.51.9
Short access total infusions1.31.52.51.31.20.61.6
Short access day 1 locomotion2.12.33.61.51.51.01.9
Short access day 10 total locomotion1.71.92.71.41.41.01.6
Short access total locomotion1.21.22.01.11.10.71.4
Compulsive drug intake4.84.86.4-2.5-2.2-1.7-2.3
One hour access (0.3 mA shock)12.014.015.43.73.93.53.8
One hour access (shock baseline)13.815.918.44.34.03.64.0
Number of responses in last shaping day0.80.81.20.61.01.10.9
Context. condit. distance diff. score1.01.21.71.01.20.91.3
Locomotion velocity, session 10.40.40.6-0.8-0.6-0.7-0.7
Locomotion distance, session 10.81.11.9-0.9-1.0-1.4-0.8
Locomotion velocity, session 22.83.24.0-1.6-1.9-2.0-1.6
Locomotion distance, session 21.01.41.7-1.1-1.3-1.3-1.0
Locomotion velocity, session 30.10.10.20.20.2-0.40.4
Locomotion distance, session 30.00.00.10.00.1-0.20.1
Stereotopy head waving bouts, day 30.10.10.30.30.3-0.20.5
Stereotopy head waving duration, day 30.40.50.70.70.70.50.8
Locomotion velocity, session 70.50.61.10.90.60.11.1
Locomotion distance, session 70.10.10.2-0.2-0.2-0.50.1
Stereotopy head waving bouts, day 70.60.61.01.00.80.50.9
Stereotopy head waving duration, day 70.20.30.6-0.2-0.6-0.8-0.3
Locomotion velocity, session 82.02.42.8-1.7-1.5-1.4-1.6
Locomotion distance, session 80.10.10.30.30.3-0.30.5
Degree of sensitization distance0.00.00.1-0.0-0.2-0.30.1
Degree of sensitization stereotypy0.00.00.10.3-0.1-0.20.1
Condit. Reinf. active minus inactive responses0.20.20.2-0.4-0.5-0.5-0.4
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.20.1-0.2
Condit. Reinf. active responses0.00.00.00.1-0.0-0.20.2
Condit. Reinf. inactive responses0.20.30.50.60.50.00.7
Incentive salience index mean0.30.30.6-0.5-0.6-0.8-0.4
Condit. Reinf. lever presses0.20.20.5-0.3-0.4-0.7-0.3
Time in familiar zone, hab. session 10.30.20.40.50.50.20.7
Time in novel zone, hab. session 10.10.10.2-0.4-0.10.1-0.3
Total zone transitions, hab. session 10.40.60.9-0.6-0.9-0.8-0.7
Total locomotion distance, hab. session 10.20.30.60.70.50.20.8
Locomotion velocity, hab. session 10.00.10.10.30.1-0.10.3
Time in familiar zone, hab. session 20.50.51.0-1.0-0.5-0.6-0.7
Time in novel zone, hab. session 20.10.10.20.40.00.20.2
Total zone transitions, hab. session 21.31.72.8-1.0-1.4-1.7-1.0
Total locomotion distance, hab. session 20.10.10.4-0.1-0.2-0.70.2
Locomotion velocity, hab. session 20.10.10.30.40.1-0.40.5
Novel to familiar place preference ratio0.10.10.10.1-0.3-0.4-0.2
Novelty place preference0.00.00.10.4-0.0-0.00.1
Time in novel zone, NPP test0.00.00.10.3-0.0-0.10.0
Total zone transitions, NPP test1.92.73.5-1.4-1.8-1.9-1.5
Total locomotion distance, NPP test0.10.20.4-0.2-0.4-0.6-0.1
Locomotion velocity, NPP test0.10.10.2-0.1-0.4-0.5-0.1
Pavlov. Cond. lever latency0.20.20.50.30.50.70.3
Pavlov. Cond. magazine entry latency0.10.10.30.1-0.2-0.50.0
Pavlov. Cond. change in total contacts0.30.30.60.80.40.30.6
Pavlov. Cond. index score0.00.00.00.0-0.2-0.2-0.1
Pavlov. Cond. latency score0.00.00.1-0.0-0.2-0.3-0.0
Pavlov. Cond. lever contacts0.00.10.2-0.1-0.2-0.4-0.1
Pavlov. Cond. magazine entry number0.00.00.0-0.20.1-0.00.1
Pavlov. Cond. intertrial magazine entries1.11.42.01.01.21.41.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.2-0.4-0.5-0.3
Pavlov. Cond. response bias0.00.00.00.1-0.0-0.0-0.0
Bone: apparent density0.20.41.2-0.1-0.5-1.1-0.0
Bone surface1.93.35.9-1.1-1.9-2.4-1.5
Bone volume0.30.61.7-0.0-0.8-1.3-0.3
Bone: connectivity density1.42.34.2-1.1-1.6-2.1-1.1
Bone: cortical apparent density0.20.30.4-0.6-0.6-0.2-0.7
Bone: cortical area0.20.40.6-0.4-0.6-0.7-0.6
Bone: cortical porosity0.00.00.1-0.1-0.3-0.2-0.0
Bone: cortical porosity0.50.50.8-0.6-0.9-0.8-0.6
Bone: cortical thickness2.94.85.7-2.2-2.3-1.8-2.4
Bone: cortical thickness1.51.82.3-1.5-1.2-1.2-1.4
Bone: cortical tissue density0.30.40.6-0.7-0.8-0.3-0.8
Bone: elastic displacement0.30.30.9-0.10.50.90.1
Bone: elastic work1.82.33.1-1.8-1.4-1.3-1.6
Bone: endosteal estimation1.02.13.41.61.50.41.8
Bone: endosteal perimeter1.93.95.42.32.00.92.3
Bone: final force2.23.75.3-1.5-2.0-2.3-1.8
Bone: final moment2.03.24.6-1.4-1.9-2.1-1.7
Bone: marrow area1.02.13.41.61.50.41.8
Bone: maximum diameter0.00.10.20.40.2-0.20.1
Bone: maximum force2.03.57.0-1.2-1.8-2.7-1.4
Bone: maximum moment1.73.06.1-1.1-1.7-2.5-1.3
Bone: minimum diameter1.11.93.41.61.30.51.8
Bone: periosteal estimation0.20.40.70.80.6-0.20.8
Bone: periosteal perimeter0.10.10.20.50.2-0.30.3
Bone: post-yield work0.71.01.91.40.4-0.71.2
Bone: stiffness1.32.04.2-0.7-1.5-2.1-1.1
Bone: tissue strength0.10.10.10.40.20.20.2
Bone: trabecular number0.10.20.50.3-0.3-0.70.1
Bone: trabecular spacing0.00.00.1-0.30.00.2-0.1
Bone: trabecular thickness0.91.01.41.10.90.81.2
Bone: trabecular tissue density3.65.05.82.02.42.32.2
Breakpoint value in progressive ratio session1.71.92.4-1.1-1.6-1.4-1.4
Distance traveled before self-admin0.20.20.3-0.0-0.5-0.5-0.4
Distance traveled after self-admin0.00.00.00.1-0.20.2-0.2
Delta time in closed arm before/after self-admin1.01.01.7-1.3-0.9-0.9-0.9
Delta time in open arm before/after self-admin0.30.20.50.70.40.50.3
Diff in mean of infusions in LGA sessions0.20.30.4-0.5-0.5-0.3-0.6
Extinction: sum of active levers before priming3.33.34.3-1.4-2.1-2.1-1.6
Active lever presses in extinction session 61.41.31.9-0.9-1.2-1.0-1.4
Delta distance traveled before/after self-admin0.00.00.1-0.20.00.3-0.1
Delta ambulatory time before/after self-admin0.10.10.3-0.5-0.20.1-0.3
Time in closed arm before self-admin0.10.10.30.50.30.00.3
Time in closed arm after self-admin0.00.00.1-0.2-0.1-0.30.1
Time in open arm before self-admin0.10.10.5-0.7-0.10.1-0.2
Time in open arm after self-admin0.10.20.50.00.20.70.0
Sum of active levers in priming session hrs 5-60.20.20.5-0.0-0.4-0.0-0.7
Time to tail flick, vehicle, before self-admin0.50.51.3-0.4-0.7-1.1-0.4
Time to tail flick, vehicle, after self-admin2.83.04.9-1.7-1.6-2.2-1.3
Time to tail flick, test, before self-admin0.30.30.60.40.5-0.10.8
Time to tail flick, test, after self-admin0.00.00.1-0.2-0.1-0.1-0.3
Delta time to tail flick, vehicle, before/after SA1.01.01.2-1.1-0.9-1.1-0.9
Delta time to tail flick, test, before/after SA0.90.81.7-0.8-0.9-0.2-1.3
Ambulatory time before self-admin0.10.10.20.4-0.1-0.10.0
Ambulatory time after self-admin0.70.71.11.10.70.80.8
Total heroin consumption4.75.76.3-2.1-2.5-2.5-2.4
Area under the delay curve0.10.10.2-0.1-0.1-0.50.1
Delay disc. indifference point, 0s delay0.10.10.4-0.2-0.1-0.60.3
Delay disc. indifference point, 16s delay1.51.51.61.31.21.21.3
Delay disc. indifference point, 2s delay0.10.10.20.20.2-0.20.4
Delay disc. indifference point, 24s delay0.10.10.2-0.5-0.2-0.2-0.3
Delay disc. indifference point, 4s delay0.20.20.3-0.5-0.3-0.6-0.1
Delay disc. indifference point, 8s delay0.30.30.5-0.5-0.4-0.7-0.3
Delay discount exponential model param0.10.10.30.20.20.5-0.0
Delay discount hyperbolic model param0.10.10.30.30.20.60.0
Fecal boli incidents, locomotor time 10.30.30.60.70.50.10.6
Change in fecal boli incidents, locomotor task0.60.60.9-0.9-0.7-0.7-0.7
Time >=10cm from walls, locomotor time 12.02.03.11.71.30.51.8
Bouts of movement, locomotor time 10.70.82.0-0.6-0.90.1-1.4
Total resting periods, locomotor time 10.30.40.9-0.3-0.60.2-1.0
Rest time, locomotor task time 11.31.42.41.01.31.50.8
Distance moved, locomotor task time 10.20.20.6-0.1-0.3-0.80.1
Vertical activity count, locomotor time 11.11.21.41.01.21.01.1
Time >=10cm from walls, locomotor time 20.20.20.40.60.20.50.3
Bouts of movement, locomotor time 20.20.20.4-0.4-0.6-0.4-0.5
Total resting periods, locomotor time 20.00.00.1-0.1-0.3-0.2-0.2
Rest time, locomotor task time 21.92.32.71.41.61.41.5
Distance moved, locomotor task time 20.91.01.3-1.0-1.1-0.8-1.1
Vertical activity count, locomotor time 20.20.20.4-0.6-0.20.1-0.6
Weight adjusted by age1.61.82.5-1.1-1.4-1.2-1.6
Seeking ratio, delayed vs. immediate footshock0.10.10.10.30.20.40.3
Locomotion in novel chamber6.58.18.83.02.92.82.7
Locomotion in novel chamber post-restriction3.44.04.62.02.21.82.0
Progressive ratio1.51.83.5-0.8-1.4-1.9-1.0
Food seeking constrained by brief footshock0.50.71.0-1.0-0.7-0.7-0.8
Seeking ratio, punishment vs. effort0.60.81.70.21.01.30.6
Run reversals in cocaine runway, females1.51.52.9-1.2-1.1-1.7-0.6
Run reversals in cocaine runway, males0.10.10.20.00.50.4-0.0
Latency to leave start box in cocaine runway0.20.20.50.50.3-0.10.7
Latency to leave start box in cocaine runway, F0.10.10.10.30.1-0.10.3
Latency to leave start box in cocaine runway, M0.00.00.10.10.1-0.20.4
Cd content in liver2.02.22.71.51.61.41.4
Co content in liver0.40.51.60.00.61.30.3
Cu content in liver0.10.10.3-0.3-0.6-0.2-0.3
Fe content in liver0.10.10.3-0.0-0.1-0.5-0.3
K content in liver1.71.73.2-1.1-1.3-1.8-0.9
Mg content in liver0.10.10.30.0-0.3-0.60.2
Mn content in liver1.11.21.5-0.8-1.2-1.2-1.2
Na content in liver0.80.91.0-0.8-1.0-1.0-0.9
Rb content in liver1.11.42.11.21.20.81.4
Se content in liver0.70.91.61.30.80.70.8
Sr content in liver2.52.33.3-1.4-1.6-1.1-1.8
Zn content in liver0.60.71.1-0.6-1.0-0.7-0.9