Hub : Genes

Sart1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000020475 0.06 0.04 3.7e-03 0.04 0.04 0.03 0.04 3.8e-03 2.5e-03 1.3e-02 4.6e-03
2 Liver gene expression ENSRNOG00000020475 0.05 0.04 3.3e-04 0.04 0.02 0.02 0.03 7.7e-05 1.9e-03 1.6e-03 3.3e-04
3 PL gene expression ENSRNOG00000020475 0.05 0.03 1.1e-03 0.05 0.04 0.04 0.05 1.1e-04 8.1e-04 4.3e-04 1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.27.19.02.43.02.6
BMI without tail1.02.02.61.21.61.4
Body weight4.017.118.54.14.34.0
Epididymis fat weight3.27.48.0-2.8-2.7-2.7
Glucose2.33.54.1-2.0-1.8-1.8
Heart weight3.85.56.4-2.4-2.5-2.1
Left kidney weight0.72.02.1-1.4-1.3-1.4
Right kidney weight0.10.30.5-0.5-0.5-0.7
Tail length0.72.23.01.71.41.3
Length with tail2.69.710.53.23.03.1
Length without tail2.96.46.92.62.52.5
Liver weight, left0.10.10.2-0.3-0.2-0.4
Liver weight, right0.00.10.1-0.2-0.3-0.3
Parametrial fat weight2.65.06.5-2.5-2.1-2.1
Retroperitoneal fat weight6.220.621.7-4.7-4.5-4.5
Intraocular pressure0.60.81.1-1.0-1.1-0.5
Extensor digitorum longus weight8.634.635.95.85.96.0
Soleus weight4.814.115.1-3.7-3.7-3.9
Tibialis anterior weight12.543.244.26.76.56.5
Tibia length1.03.03.21.81.81.6
Number of licking bursts0.30.40.50.60.70.5
Food consumed during 24 hour testing period0.00.00.00.20.20.1
Times rat made contact with spout0.40.50.50.70.70.6
Mean time between licks in bursts0.60.81.11.01.00.5
Mean num. licks in bursts0.20.30.4-0.5-0.6-0.5
Std. dev. time between licks in bursts0.00.00.00.1-0.1-0.1
Water consumed over 24 hours0.81.01.11.01.01.0
Indifference point 0 sec0.00.10.1-0.3-0.1-0.3
Indifference point AUC4.24.95.12.22.32.2
Indifference point function ln k9.613.614.4-3.5-3.8-3.8
Indifference point function log k9.613.614.4-3.5-3.8-3.8
Delay discounting total patch changes 0 sec0.00.00.0-0.1-0.0-0.1
Delay discounting total patch changes 12 sec5.57.48.12.62.92.6
Delay discounting total patch changes 18 sec0.60.81.00.81.00.9
Delay discounting total patch changes 24 sec2.93.64.02.02.01.7
Delay discounting total patch changes 6 sec1.32.02.41.31.41.6
Delay discounting time to switch 0 sec1.82.83.41.41.81.8
Delay discounting water rate 0 sec4.16.67.3-2.4-2.6-2.7
Delay discounting water rate 12 sec9.213.815.6-3.4-3.9-3.8
Delay discounting water rate 18 sec3.64.85.4-2.0-2.3-2.2
Delay discounting water rate 24 sec4.66.47.2-2.3-2.7-2.6
Delay discounting water rate 6 sec4.05.86.8-2.1-2.6-2.5
Locomotor activity1.82.83.4-1.4-1.9-1.8
Locomotor testing distance2.64.35.5-1.6-2.3-2.2
Locomotor testing rearing2.33.64.6-1.7-2.1-1.8
Light reinforcement 10.10.30.4-0.5-0.5-0.6
Light reinforcement 21.11.51.6-1.2-1.2-1.2
Reaction time number correct0.40.50.70.80.60.7
Reaction time mean minus median3.64.75.42.02.22.3
Reaction time mean minus median AUC2.32.93.71.61.61.9
Reaction time num false alarms0.10.10.2-0.3-0.4-0.3
Reaction time num false alarms AUC0.10.10.20.40.20.4
Reaction time trials correct on left0.40.50.70.80.60.7
Reaction time trials on left0.50.70.90.90.70.9
Reaction time mean0.00.10.20.10.40.1
Reaction time mean AUC0.00.00.1-0.00.40.0
Median of all reaction times0.10.10.2-0.40.0-0.5
Reaction time omissions1.82.53.61.41.31.9
Reaction time false alarm rate0.10.10.2-0.3-0.4-0.2
Reaction time premature initiation rate2.73.64.32.11.91.7
Reaction time premature initiations4.46.37.42.72.42.3
Std. dev. reaction times1.11.41.71.01.31.3
Reaction time trials completed0.50.70.90.90.70.9
Reaction time trials AUC0.30.40.50.70.50.7
Social response proportion0.91.01.31.01.10.9
Social responses0.30.50.50.70.60.7
Social time0.40.50.70.80.70.6
Conditioned locomotion2.22.63.01.61.51.7
Cocaine response after cond. corrected1.51.72.1-1.3-1.5-1.1
Cocaine response after cond. not corrected1.21.31.6-1.1-1.3-1.1
Cocaine response before conditioning0.60.71.00.91.00.6
Saline control response4.56.06.92.52.62.2
Condit. Reinf. active minus inactive responses0.20.30.4-0.5-0.4-0.7
Condit. Reinf. active-inactive response ratio1.01.01.3-1.0-0.9-1.1
Condit. Reinf. active responses0.00.00.0-0.00.2-0.1
Condit. Reinf. inactive responses0.30.40.40.60.60.7
Condit. Reinf. lever presses2.33.13.31.71.81.8
Condit. Reinf. lever reinforcers received0.10.20.30.40.60.3
Pavlov. Cond. lever latency0.50.70.8-0.8-0.8-0.9
Pavlov. Cond. magazine entry latency4.14.75.22.12.12.3
Pavlov. Cond. change in total contacts1.82.42.71.41.61.6
Pavlov. Cond. index score2.53.33.51.71.81.9
Pavlov. Cond. latency score2.12.62.81.51.61.7
Pavlov. Cond. lever contacts0.50.70.70.80.90.8
Pavlov. Cond. magazine entry number7.08.79.0-2.9-3.0-3.0
Pavlov. Cond. intertrial magazine entries1.51.91.9-1.4-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.3.14.14.31.92.02.1
Pavlov. Cond. response bias1.92.72.81.61.71.7
Conditioned reinforcement - actives0.20.20.3-0.4-0.6-0.4
Conditioned reinforcement - inactives6.67.58.0-2.8-2.8-2.6
Conditioned locomotion9.111.011.4-3.3-3.4-3.3
Intermittent access intake day 1-15 change0.40.40.6-0.6-0.8-0.5
Intermittent access intake escalation0.40.40.6-0.7-0.8-0.5
Intermittent access intake escalation 20.10.10.1-0.3-0.3-0.2
Intermitt. access day 1 inactive lever presses2.42.63.1-1.8-1.7-1.3
Intermitt. access day 15 inactive lever presses2.42.63.2-1.7-1.8-1.3
Intermitt. access escalation Index4.94.45.3-2.0-2.0-2.3
Intermittent access day 1 total infusions6.57.48.9-3.0-2.7-2.4
Intermittent access day 15 total infusions8.89.911.1-3.3-3.3-2.8
Intermittent access terminal intake (last 3 days)6.16.77.9-2.8-2.7-2.2
Intermittent access total infusions5.25.76.9-2.6-2.6-1.9
Intermittent access day 1 locomotion4.24.35.4-2.3-2.2-1.6
Intermittent access day 15 total locomotion5.45.76.7-2.6-2.5-2.0
Intermittent access total locomotion7.18.09.9-3.1-2.9-2.4
Intermittent access standard deviation1.21.21.7-1.1-1.3-0.9
Cocaine induced anxiety0.00.00.00.00.00.2
Post-drug Anxiety1.71.82.01.41.31.4
Baseline Anxiety2.93.13.41.91.81.6
Lifetime Intake4.55.16.1-2.5-2.4-1.8
Incentive Sensitization - Responses0.40.40.5-0.7-0.7-0.4
Incentive Sensitization - Breakpoint0.60.60.8-0.9-0.9-0.6
Progressive ratio test 1 active lever presses3.33.44.2-1.9-2.0-1.6
Progressive ratio test 1 breakpoint2.93.03.7-1.8-1.9-1.5
Progressive ratio test 1 inactive lever presses1.51.61.8-1.3-1.3-1.2
Progressive ratio test 2 active lever presses4.75.05.8-2.4-2.4-1.9
Progressive ratio test 2 breakpoint5.86.57.6-2.6-2.7-2.2
Progressive ratio test 2 inactive lever presses10.111.612.8-3.6-3.5-3.1
Total sessions with >9 infusions1.92.02.4-1.5-1.5-1.2
Short access day 1 total inactive lever presses4.65.15.4-2.3-2.2-2.3
Short access day 10 total inactive lever presses3.74.14.5-2.1-2.1-1.9
Short access day 1 total infusions3.73.94.6-2.1-1.9-1.9
Short access day 10 total infusions1.61.82.5-1.6-1.4-1.0
Short access total infusions1.61.82.2-1.5-1.4-1.1
Short access day 1 locomotion2.62.83.5-1.9-1.8-1.2
Short access day 10 total locomotion1.82.02.5-1.6-1.5-1.1
Short access total locomotion1.61.62.0-1.4-1.4-1.0
Compulsive drug intake3.13.13.71.91.71.7
One hour access (0.3 mA shock)11.113.015.3-3.7-3.9-3.1
One hour access (shock baseline)10.011.612.9-3.6-3.6-3.0
Number of responses in last shaping day1.41.41.8-1.1-1.3-1.1
Context. condit. distance diff. score2.32.83.0-1.7-1.6-1.7
Locomotion velocity, session 10.10.10.10.20.0-0.4
Locomotion distance, session 10.30.30.50.70.60.4
Locomotion velocity, session 22.83.23.41.91.81.7
Locomotion distance, session 20.60.80.91.00.90.9
Locomotion velocity, session 30.10.20.2-0.4-0.5-0.3
Locomotion distance, session 30.00.00.1-0.2-0.3-0.1
Stereotopy head waving bouts, day 30.70.91.1-0.9-0.8-1.0
Stereotopy head waving duration, day 31.01.31.6-1.1-1.0-1.3
Locomotion velocity, session 70.40.50.7-0.8-0.8-0.4
Locomotion distance, session 70.00.00.1-0.2-0.20.1
Stereotopy head waving bouts, day 70.20.20.3-0.6-0.4-0.4
Stereotopy head waving duration, day 70.81.01.30.81.01.1
Locomotion velocity, session 81.01.21.61.31.11.0
Locomotion distance, session 80.30.40.6-0.6-0.5-0.8
Degree of sensitization distance0.00.00.0-0.1-0.00.2
Degree of sensitization stereotypy0.50.50.80.50.70.9
Condit. Reinf. active minus inactive responses0.10.10.20.40.50.2
Condit. Reinf. active-inactive response ratio0.00.00.00.20.1-0.0
Condit. Reinf. active responses0.10.10.10.20.30.3
Condit. Reinf. inactive responses0.00.00.0-0.2-0.10.1
Incentive salience index mean0.20.30.40.60.60.4
Condit. Reinf. lever presses0.30.40.50.60.70.6
Time in familiar zone, hab. session 10.30.30.3-0.5-0.5-0.5
Time in novel zone, hab. session 10.10.10.2-0.3-0.4-0.4
Total zone transitions, hab. session 10.60.91.11.01.00.9
Total locomotion distance, hab. session 10.40.60.6-0.8-0.7-0.8
Locomotion velocity, hab. session 10.00.10.1-0.2-0.2-0.3
Time in familiar zone, hab. session 20.00.00.00.2-0.00.1
Time in novel zone, hab. session 20.00.00.00.00.20.1
Total zone transitions, hab. session 20.91.21.61.11.30.9
Total locomotion distance, hab. session 20.10.10.1-0.3-0.1-0.4
Locomotion velocity, hab. session 20.20.20.3-0.5-0.3-0.6
Novel to familiar place preference ratio1.01.11.30.91.21.1
Novelty place preference0.40.40.50.50.70.7
Time in novel zone, NPP test0.30.30.40.40.60.6
Total zone transitions, NPP test1.92.73.41.71.91.3
Total locomotion distance, NPP test0.00.00.00.10.2-0.2
Locomotion velocity, NPP test0.00.00.10.20.3-0.1
Pavlov. Cond. lever latency0.20.30.3-0.5-0.6-0.5
Pavlov. Cond. magazine entry latency0.10.10.20.10.40.2
Pavlov. Cond. change in total contacts0.00.00.0-0.00.2-0.0
Pavlov. Cond. index score0.10.10.20.30.40.2
Pavlov. Cond. latency score0.00.00.10.10.30.1
Pavlov. Cond. lever contacts0.00.00.00.00.10.0
Pavlov. Cond. magazine entry number0.20.20.3-0.4-0.6-0.4
Pavlov. Cond. intertrial magazine entries0.30.40.6-0.6-0.8-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.40.50.60.4
Pavlov. Cond. response bias0.10.10.10.20.30.2
Bone: apparent density0.20.40.40.40.70.7
Bone surface3.96.87.82.42.82.6
Bone volume1.11.92.31.21.51.4
Bone: connectivity density2.03.23.61.61.91.9
Bone: cortical apparent density0.30.40.40.60.70.7
Bone: cortical area0.81.21.61.11.01.2
Bone: cortical porosity0.00.00.10.20.30.1
Bone: cortical porosity0.50.60.80.70.90.6
Bone: cortical thickness3.86.37.72.62.12.8
Bone: cortical thickness1.01.11.51.20.71.2
Bone: cortical tissue density0.40.60.60.70.80.7
Bone: elastic displacement0.80.91.5-0.7-1.2-0.8
Bone: elastic work0.91.21.61.20.91.1
Bone: endosteal estimation1.22.63.4-1.6-1.3-1.8
Bone: endosteal perimeter1.63.44.5-1.8-1.5-2.1
Bone: final force3.04.95.72.22.42.0
Bone: final moment2.64.25.02.12.21.9
Bone: marrow area1.32.73.5-1.7-1.4-1.9
Bone: maximum diameter0.10.20.20.40.50.2
Bone: maximum force3.15.56.52.32.62.2
Bone: maximum moment2.64.65.52.12.32.0
Bone: minimum diameter0.91.72.1-1.4-1.2-1.2
Bone: periosteal estimation0.00.00.1-0.2-0.2-0.2
Bone: periosteal perimeter0.00.00.10.20.30.1
Bone: post-yield work0.10.20.5-0.00.70.2
Bone: stiffness2.53.95.01.82.21.8
Bone: tissue strength0.00.00.00.10.2-0.0
Bone: trabecular number0.40.61.00.50.81.0
Bone: trabecular spacing0.20.30.5-0.4-0.5-0.7
Bone: trabecular thickness0.60.70.8-0.9-0.8-0.7
Bone: trabecular tissue density4.15.76.3-2.3-2.3-2.5
Breakpoint value in progressive ratio session3.94.44.62.02.12.2
Distance traveled before self-admin0.50.50.60.70.80.6
Distance traveled after self-admin0.20.20.40.40.60.4
Delta time in closed arm before/after self-admin0.10.10.20.30.10.4
Delta time in open arm before/after self-admin0.00.00.10.10.20.2
Diff in mean of infusions in LGA sessions0.60.71.00.80.71.0
Extinction: sum of active levers before priming5.35.45.82.22.42.3
Active lever presses in extinction session 62.92.83.01.71.61.7
Delta distance traveled before/after self-admin0.00.00.0-0.0-0.00.0
Delta ambulatory time before/after self-admin0.00.00.00.10.10.1
Time in closed arm before self-admin0.00.00.00.00.1-0.2
Time in closed arm after self-admin0.00.00.0-0.1-0.0-0.0
Time in open arm before self-admin0.40.40.6-0.6-0.8-0.6
Time in open arm after self-admin0.10.10.3-0.3-0.5-0.3
Sum of active levers in priming session hrs 5-62.01.92.01.41.41.4
Time to tail flick, vehicle, before self-admin0.30.30.40.60.60.6
Time to tail flick, vehicle, after self-admin1.31.41.71.11.11.3
Time to tail flick, test, before self-admin0.80.80.9-0.9-0.9-0.8
Time to tail flick, test, after self-admin0.00.00.00.10.10.1
Delta time to tail flick, vehicle, before/after SA0.50.50.60.60.60.8
Delta time to tail flick, test, before/after SA1.71.51.71.31.11.2
Ambulatory time before self-admin0.40.40.50.50.70.7
Ambulatory time after self-admin0.10.10.1-0.4-0.0-0.2
Total heroin consumption6.47.68.12.82.82.7
Area under the delay curve0.20.20.2-0.4-0.3-0.5
Delay disc. indifference point, 0s delay0.91.01.2-0.9-1.0-1.1
Delay disc. indifference point, 16s delay1.11.11.4-1.2-0.9-1.0
Delay disc. indifference point, 2s delay0.20.20.4-0.4-0.4-0.6
Delay disc. indifference point, 24s delay0.10.10.1-0.2-0.3-0.2
Delay disc. indifference point, 4s delay0.20.30.3-0.5-0.5-0.5
Delay disc. indifference point, 8s delay0.10.10.1-0.3-0.3-0.3
Delay discount exponential model param0.10.10.10.30.30.3
Delay discount hyperbolic model param0.10.10.10.30.20.3
Fecal boli incidents, locomotor time 10.00.10.1-0.00.00.4
Change in fecal boli incidents, locomotor task0.00.00.00.10.2-0.1
Time >=10cm from walls, locomotor time 10.80.81.4-1.2-0.8-0.7
Bouts of movement, locomotor time 11.61.71.81.31.31.3
Total resting periods, locomotor time 11.11.21.31.11.11.1
Rest time, locomotor task time 11.61.72.1-1.2-1.3-1.4
Distance moved, locomotor task time 10.10.10.20.20.30.4
Vertical activity count, locomotor time 11.31.31.6-1.2-1.3-1.0
Time >=10cm from walls, locomotor time 20.00.00.0-0.00.1-0.1
Bouts of movement, locomotor time 20.80.81.10.70.91.0
Total resting periods, locomotor time 20.40.40.60.50.70.8
Rest time, locomotor task time 22.93.43.6-1.8-1.9-1.8
Distance moved, locomotor task time 21.31.61.71.31.21.2
Vertical activity count, locomotor time 20.00.00.10.30.00.1
Weight adjusted by age2.83.13.41.81.61.9
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.2-0.0-0.1
Locomotion in novel chamber5.56.86.9-2.6-2.6-2.6
Locomotion in novel chamber post-restriction3.54.14.2-2.1-2.0-2.0
Progressive ratio1.72.02.41.21.51.4
Food seeking constrained by brief footshock0.20.30.40.60.50.5
Seeking ratio, punishment vs. effort1.41.72.0-1.1-1.4-1.4
Run reversals in cocaine runway, females0.30.30.40.50.50.7
Run reversals in cocaine runway, males0.10.10.2-0.2-0.5-0.0
Latency to leave start box in cocaine runway0.00.00.1-0.3-0.2-0.0
Latency to leave start box in cocaine runway, F0.00.00.0-0.1-0.10.1
Latency to leave start box in cocaine runway, M0.00.00.0-0.00.00.1
Cd content in liver1.41.51.6-1.3-1.2-1.2
Co content in liver1.31.51.7-1.1-1.3-1.3
Cu content in liver0.30.30.40.50.50.6
Fe content in liver0.10.10.20.40.30.4
K content in liver1.71.72.01.21.31.4
Mg content in liver0.10.10.10.10.20.3
Mn content in liver3.23.64.41.81.82.1
Na content in liver1.01.11.41.21.20.7
Rb content in liver1.72.12.5-1.6-1.5-1.4
Se content in liver0.00.00.0-0.1-0.10.1
Sr content in liver3.93.63.81.91.91.9
Zn content in liver1.41.51.91.11.21.4