Hub : Genes

ENSRNOG00000065195

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000065195	0.19	0.13	5.0e-16	0.13	0.12	0.13	0.14	2.5e-14	4.5e-13	2.9e-14	5.9e-15
2	Adipose	mRNA stability	ENSRNOG00000065195	0.29	0.13	0.0e+00	0.24	0.26	0.25	0.25	1.2e-26	3.4e-28	4.7e-27	1.7e-27
3	Eye	mRNA stability	ENSRNOG00000065195	0.32	0.21	2.1e-03	0.17	0.08	0.16	0.1	1.3e-03	2.5e-02	2.3e-03	1.1e-02
4	LHb	gene expression	ENSRNOG00000065195	0.33	0.25	2.5e-05	0.21	0.17	0.16	0.19	1.2e-05	6.3e-05	1.3e-04	3.3e-05
5	Liver	gene expression	ENSRNOG00000065195	0.13	0.08	9.0e-15	0.12	0.12	0.1	0.12	3.9e-13	8.8e-13	1.7e-11	3.2e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.7	5.5	6.7	-2.3	2.0	2.5	-2.3	-2.6
BMI without tail	0.9	1.9	2.3	-1.5	1.3	1.2	-1.4	-1.5
Body weight	1.5	6.3	7.8	2.5	-2.8	-2.4	2.5	2.3
Epididymis fat weight	2.0	4.6	5.7	-2.1	1.7	2.4	-2.3	-2.1
Glucose	0.0	0.0	0.1	0.0	0.2	-0.2	-0.0	0.1
Heart weight	0.2	0.3	0.4	-0.6	0.6	0.4	-0.3	-0.6
Left kidney weight	2.7	7.7	8.7	2.9	-2.9	-2.4	2.9	2.6
Right kidney weight	1.3	3.7	4.4	2.0	-1.9	-1.9	2.1	1.6
Tail length	5.1	15.5	18.4	3.8	-3.8	-4.3	3.9	3.9
Length with tail	9.7	35.5	36.5	5.8	-6.0	-6.0	6.0	6.0
Length without tail	6.2	13.6	14.8	3.7	-3.8	-3.4	3.8	3.7
Liver weight, left	2.4	3.9	4.3	2.0	-2.1	-1.9	2.1	1.9
Liver weight, right	0.8	1.3	1.6	1.1	-1.3	-1.0	1.1	1.1
Parametrial fat weight	0.1	0.2	0.2	-0.4	0.5	0.3	-0.4	-0.5
Retroperitoneal fat weight	0.0	0.1	0.1	-0.3	0.1	0.1	-0.3	-0.1
Intraocular pressure	0.3	0.4	0.7	-0.7	0.8	0.0	-0.8	-0.4
Extensor digitorum longus weight	10.1	40.7	43.1	6.4	-6.2	-6.4	6.6	6.4
Soleus weight	2.8	8.1	9.8	2.8	-3.1	-2.6	2.9	2.8
Tibialis anterior weight	1.2	4.1	4.8	2.1	-2.0	-1.8	2.2	2.1
Tibia length	0.0	0.1	0.2	0.4	-0.5	0.1	0.2	0.3
Number of licking bursts	1.1	1.2	2.0	-1.1	1.4	0.8	-1.2	-1.1
Food consumed during 24 hour testing period	1.2	1.4	2.1	1.1	-1.1	-1.4	1.1	1.1
Times rat made contact with spout	0.4	0.5	1.0	0.6	-0.6	-1.0	0.6	0.6
Mean time between licks in bursts	0.7	1.0	1.1	-1.0	0.9	1.0	-1.1	-0.9
Mean num. licks in bursts	1.7	2.0	2.8	1.3	-1.7	-1.3	1.5	1.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	-0.3	-0.3	0.4	0.4
Water consumed over 24 hours	1.1	1.3	1.9	1.2	-0.9	-1.4	1.1	1.1
Indifference point 0 sec	6.6	10.7	12.0	3.3	-3.5	-2.8	3.4	3.3
Indifference point AUC	7.6	9.0	11.2	3.1	-3.3	-2.4	3.1	3.0
Indifference point function ln k	0.2	0.3	0.6	0.5	-0.2	-0.8	0.4	0.6
Indifference point function log k	0.2	0.3	0.6	0.5	-0.2	-0.8	0.4	0.6
Delay discounting total patch changes 0 sec	8.0	13.0	14.5	3.7	-3.8	-3.2	3.7	3.6
Delay discounting total patch changes 12 sec	4.0	5.3	5.9	2.3	-2.2	-2.2	2.4	2.4
Delay discounting total patch changes 18 sec	3.1	4.1	4.6	1.9	-2.1	-1.7	2.1	2.1
Delay discounting total patch changes 24 sec	1.5	1.9	2.6	1.4	-1.6	-1.1	1.5	1.3
Delay discounting total patch changes 6 sec	7.2	11.0	14.0	3.3	-3.7	-2.7	3.4	3.3
Delay discounting time to switch 0 sec	12.3	18.7	20.1	-4.5	4.3	4.3	-4.4	-4.2
Delay discounting water rate 0 sec	17.1	27.3	29.7	5.5	-5.1	-5.2	5.3	5.1
Delay discounting water rate 12 sec	5.0	7.5	12.2	2.6	-2.1	-3.5	2.6	2.6
Delay discounting water rate 18 sec	3.3	4.3	5.7	2.3	-1.8	-2.4	2.1	1.8
Delay discounting water rate 24 sec	2.2	3.1	3.7	1.9	-1.6	-1.9	1.8	1.5
Delay discounting water rate 6 sec	3.9	5.7	6.6	2.6	-2.3	-2.5	2.4	2.2
Locomotor activity	0.1	0.1	0.2	0.4	-0.3	-0.5	0.2	0.3
Locomotor testing distance	0.1	0.1	0.2	0.3	-0.1	-0.5	0.2	0.4
Locomotor testing rearing	1.6	2.6	3.0	-1.5	1.7	1.6	-1.7	-1.5
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.1	0.2	0.1	-0.0
Light reinforcement 2	1.4	1.8	2.4	-1.2	1.1	1.5	-1.4	-1.3
Reaction time number correct	4.4	6.3	7.0	2.5	-2.5	-2.5	2.5	2.6
Reaction time mean minus median	0.0	0.1	0.1	-0.4	0.2	-0.1	-0.2	-0.0
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.3	0.2	-0.3	-0.1	0.2
Reaction time num false alarms	1.9	2.7	3.2	1.5	-1.7	-1.8	1.5	1.6
Reaction time num false alarms AUC	1.9	2.7	3.3	1.6	-1.7	-1.8	1.5	1.6
Reaction time trials correct on left	4.4	6.3	7.0	2.5	-2.5	-2.5	2.5	2.6
Reaction time trials on left	4.5	6.3	6.9	2.5	-2.4	-2.5	2.5	2.6
Reaction time mean	2.2	3.0	4.1	-1.9	2.0	1.1	-1.9	-1.6
Reaction time mean AUC	1.4	1.8	2.6	-1.5	1.6	0.7	-1.4	-1.2
Median of all reaction times	2.0	2.7	4.0	-1.8	2.0	1.0	-1.8	-1.6
Reaction time omissions	0.9	1.2	2.4	0.8	-0.8	-1.5	1.0	1.1
Reaction time false alarm rate	0.1	0.1	0.3	0.3	-0.4	-0.6	0.2	0.3
Reaction time premature initiation rate	0.1	0.2	0.4	0.4	-0.2	-0.4	0.4	0.6
Reaction time premature initiations	2.1	3.0	3.8	1.7	-1.6	-1.6	1.7	2.0
Std. dev. reaction times	1.4	1.9	2.7	-1.6	1.7	0.7	-1.5	-1.2
Reaction time trials completed	4.5	6.3	6.9	2.5	-2.4	-2.5	2.5	2.6
Reaction time trials AUC	4.5	6.5	7.0	2.6	-2.5	-2.5	2.6	2.6
Social response proportion	0.8	0.9	1.2	-0.8	1.1	0.6	-1.0	-1.0
Social responses	0.6	0.7	1.0	-0.9	1.0	0.5	-1.0	-0.8
Social time	0.2	0.2	0.5	-0.4	0.7	-0.6	-0.4	-0.1
Conditioned locomotion	1.7	2.1	2.2	1.4	-1.4	-1.4	1.5	1.4
Cocaine response after cond. corrected	0.1	0.1	0.2	0.2	-0.4	0.1	0.2	0.1
Cocaine response after cond. not corrected	0.2	0.3	0.8	-0.4	0.1	0.9	-0.4	-0.5
Cocaine response before conditioning	3.1	3.8	4.9	-1.9	1.8	2.2	-2.0	-1.9
Saline control response	0.1	0.1	0.2	0.3	-0.3	-0.2	0.5	0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.7	-0.4	-0.3	0.5	0.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.2	0.4	-0.0	0.0	0.2	0.1
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	0.2	0.2	-0.2	-0.0
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.7	0.5	0.3	-0.6	-0.4
Condit. Reinf. lever presses	2.3	3.2	3.6	-1.8	1.9	1.9	-1.7	-1.7
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.0	0.2	0.0	-0.1	0.1
Pavlov. Cond. lever latency	3.7	5.0	5.3	2.2	-2.3	-2.3	2.3	2.2
Pavlov. Cond. magazine entry latency	3.6	4.2	5.2	-2.0	1.9	2.3	-1.9	-2.0
Pavlov. Cond. change in total contacts	6.4	9.0	9.5	-2.9	3.0	3.1	-3.0	-3.0
Pavlov. Cond. index score	5.0	6.5	7.2	-2.5	2.5	2.7	-2.5	-2.5
Pavlov. Cond. latency score	4.4	5.6	6.9	-2.3	2.3	2.6	-2.3	-2.3
Pavlov. Cond. lever contacts	3.7	5.1	5.3	-2.2	2.3	2.3	-2.3	-2.2
Pavlov. Cond. magazine entry number	3.0	3.7	4.2	1.9	-1.9	-2.1	1.8	1.9
Pavlov. Cond. intertrial magazine entries	4.5	5.8	7.1	2.4	-2.2	-2.7	2.2	2.5
Pavlov. Cond. lever-magazine prob. diff.	5.7	7.4	8.3	-2.7	2.7	2.9	-2.7	-2.6
Pavlov. Cond. response bias	3.8	5.2	5.3	-2.2	2.3	2.3	-2.3	-2.3
Conditioned reinforcement - actives	1.0	1.0	1.4	1.0	-0.7	-1.2	0.9	1.1
Conditioned reinforcement - inactives	0.5	0.6	0.9	0.6	-0.6	-0.9	0.6	0.9
Conditioned locomotion	0.0	0.0	0.1	-0.0	-0.1	0.3	-0.1	0.1
Intermittent access intake day 1-15 change	1.3	1.3	1.4	-1.1	1.1	1.1	-1.2	-1.1
Intermittent access intake escalation	1.2	1.2	1.4	-1.1	1.1	1.1	-1.2	-1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	0.3	0.4	-0.3	-0.2
Intermitt. access day 1 inactive lever presses	3.2	3.5	4.2	1.8	-1.6	-2.0	1.8	2.1
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.2	0.7	-0.4	-1.1	0.7	0.9
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.1	-0.2	0.1	0.1
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.5	-0.5	0.0	0.3	0.3
Intermittent access day 15 total infusions	0.7	0.8	1.2	-0.7	0.8	1.1	-1.0	-0.9
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.3	-0.9	1.0	1.1	-1.1	-1.0
Intermittent access total infusions	0.0	0.0	0.1	-0.0	0.1	0.4	-0.3	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.1	-0.1	0.5	-0.1	-0.2
Intermittent access day 15 total locomotion	0.0	0.1	0.1	-0.1	0.2	0.3	-0.2	-0.3
Intermittent access total locomotion	0.1	0.1	0.1	0.4	-0.4	0.1	0.2	0.1
Intermittent access standard deviation	0.4	0.4	1.3	-0.5	0.2	1.1	-0.6	-0.5
Cocaine induced anxiety	0.3	0.4	0.7	0.5	-0.4	-0.8	0.7	0.6
Post-drug Anxiety	0.3	0.3	0.5	0.6	-0.5	-0.7	0.7	0.4
Baseline Anxiety	0.6	0.7	1.0	-0.8	0.6	1.0	-0.7	-0.9
Lifetime Intake	0.1	0.1	0.2	-0.2	0.3	0.3	-0.4	-0.3
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.3	0.5	0.2	-0.4	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.5	0.1	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	-0.2	0.4	0.0	-0.4	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.3	0.4	0.2	-0.4	-0.1
Progressive ratio test 1 inactive lever presses	2.3	2.5	3.6	1.5	-1.2	-1.9	1.4	1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.0	0.2	0.1	-0.3	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	0.1	0.3	-0.6	-0.1	0.3
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	0.2	0.1	-0.3	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.2	0.3	-0.1	-0.3	-0.2
Short access day 10 total inactive lever presses	0.2	0.2	0.7	0.3	-0.1	-0.9	0.3	0.5
Short access day 1 total infusions	0.0	0.0	0.1	0.0	0.3	-0.3	-0.2	-0.0
Short access day 10 total infusions	0.2	0.3	0.3	-0.4	0.5	0.6	-0.6	-0.5
Short access total infusions	0.8	0.8	1.1	-0.8	1.0	0.7	-1.0	-0.9
Short access day 1 locomotion	0.4	0.4	0.5	-0.7	0.7	0.5	-0.7	-0.6
Short access day 10 total locomotion	0.0	0.0	0.1	0.1	-0.2	0.3	-0.0	0.0
Short access total locomotion	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	-0.2
Compulsive drug intake	0.6	0.6	1.1	0.8	-1.1	-0.5	0.8	0.7
One hour access (0.3 mA shock)	0.6	0.8	0.8	0.9	-0.9	-0.7	0.9	0.9
One hour access (shock baseline)	0.1	0.1	0.2	-0.2	0.4	0.0	-0.3	0.0
Number of responses in last shaping day	0.7	0.7	0.8	-0.8	0.9	0.8	-0.8	-0.8
Context. condit. distance diff. score	3.3	4.0	5.0	2.2	-1.8	-1.8	2.0	2.1
Locomotion velocity, session 1	0.3	0.3	0.4	0.6	-0.4	-0.6	0.5	0.6
Locomotion distance, session 1	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	-0.2
Locomotion velocity, session 2	0.3	0.4	0.6	-0.6	0.8	0.5	-0.6	-0.6
Locomotion distance, session 2	0.7	1.0	1.3	-0.8	1.1	0.9	-0.9	-1.2
Locomotion velocity, session 3	0.0	0.0	0.1	0.2	0.0	0.1	0.3	0.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.3	0.3	-0.0	-0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.3	-0.3	0.4	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	-0.2	-0.4	0.4	0.2
Locomotion velocity, session 7	0.2	0.2	0.4	0.3	-0.5	-0.7	0.2	0.3
Locomotion distance, session 7	0.7	0.9	1.0	-1.0	1.0	0.8	-1.0	-0.9
Stereotopy head waving bouts, day 7	2.9	3.3	3.4	1.7	-1.8	-1.8	1.9	1.8
Stereotopy head waving duration, day 7	1.9	2.4	2.7	1.4	-1.6	-1.5	1.6	1.5
Locomotion velocity, session 8	2.3	2.8	3.3	1.8	-1.8	-1.4	1.7	1.6
Locomotion distance, session 8	0.5	0.8	1.2	1.1	-0.8	-0.7	0.9	0.8
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.4	0.2	-0.6	-0.6
Degree of sensitization stereotypy	1.2	1.3	1.5	1.0	-1.2	-1.1	1.1	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	0.3	0.3	-0.4	-0.2
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.9	-1.2	1.1	1.1	-1.4	-1.1
Condit. Reinf. active responses	0.2	0.2	0.3	0.3	-0.5	-0.5	0.4	0.5
Condit. Reinf. inactive responses	2.7	3.2	3.7	1.7	-1.7	-1.8	1.9	1.8
Incentive salience index mean	0.1	0.1	0.2	0.2	-0.4	-0.3	0.2	0.3
Condit. Reinf. lever presses	0.3	0.4	0.8	0.6	-0.9	-0.6	0.6	0.6
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	0.1
Time in novel zone, hab. session 1	0.9	0.9	1.3	-0.9	1.0	0.7	-1.1	-1.0
Total zone transitions, hab. session 1	0.7	1.0	1.2	-0.9	1.1	1.0	-1.0	-1.0
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.1	0.4	0.0	-0.2	-0.2
Locomotion velocity, hab. session 1	0.2	0.2	0.3	0.6	-0.3	-0.5	0.5	0.5
Time in familiar zone, hab. session 2	0.6	0.7	1.1	0.8	-1.0	-0.7	0.9	0.6
Time in novel zone, hab. session 2	1.2	1.2	1.6	-1.1	1.2	1.0	-1.2	-0.9
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.3	0.5	-0.4	-0.6	0.6	0.5
Locomotion velocity, hab. session 2	0.4	0.5	0.6	0.7	-0.6	-0.8	0.8	0.7
Novel to familiar place preference ratio	0.6	0.6	0.9	-0.8	0.9	0.7	-0.8	-0.5
Novelty place preference	0.8	0.8	1.3	-0.9	1.1	0.7	-0.9	-0.7
Time in novel zone, NPP test	0.2	0.2	0.4	-0.5	0.7	0.3	-0.5	-0.3
Total zone transitions, NPP test	0.7	1.1	1.2	1.1	-0.9	-1.1	1.0	1.0
Total locomotion distance, NPP test	0.4	0.6	0.7	0.8	-0.6	-0.8	0.7	0.8
Locomotion velocity, NPP test	0.2	0.3	0.4	0.6	-0.4	-0.6	0.5	0.6
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.2	-0.0	0.0	-0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.1	-0.3	-0.1	0.3	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.0	0.0
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.4	0.2	0.5	-0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	-0.2	0.4	0.1	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	9.5	11.4	12.0	3.3	-3.2	-3.4	3.5	3.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.0	-0.3	0.1	-0.0	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	-0.5	-0.1	0.1	0.1
Bone: apparent density	0.0	0.1	0.1	0.2	-0.3	-0.0	0.3	0.3
Bone surface	0.3	0.5	0.8	-0.6	0.8	0.9	-0.6	-0.8
Bone volume	0.3	0.4	0.6	-0.6	0.7	0.8	-0.5	-0.7
Bone: connectivity density	0.3	0.5	0.7	0.8	-0.7	-0.3	0.8	0.8
Bone: cortical apparent density	3.8	5.0	6.0	2.2	-1.9	-2.4	2.2	2.4
Bone: cortical area	0.2	0.3	0.4	0.6	-0.4	-0.3	0.6	0.5
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.3	-0.1	0.4	0.3
Bone: cortical porosity	0.1	0.1	0.3	0.4	-0.5	-0.0	0.4	0.3
Bone: cortical thickness	0.8	1.3	1.5	1.2	-1.2	-0.8	1.2	1.2
Bone: cortical thickness	0.6	0.7	1.0	0.8	-0.7	-0.8	1.0	1.0
Bone: cortical tissue density	3.7	4.9	5.8	2.2	-1.9	-2.4	2.1	2.4
Bone: elastic displacement	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.2	-0.0
Bone: elastic work	1.0	1.3	2.0	-1.2	1.4	0.9	-1.1	-1.0
Bone: endosteal estimation	1.7	3.6	4.9	-1.9	2.2	1.7	-1.8	-1.9
Bone: endosteal perimeter	0.2	0.5	0.7	-0.6	0.8	0.9	-0.5	-0.8
Bone: final force	0.3	0.5	0.9	-0.5	0.8	0.9	-0.4	-0.6
Bone: final moment	0.1	0.2	0.5	-0.3	0.6	0.7	-0.2	-0.4
Bone: marrow area	1.7	3.6	4.9	-1.8	2.2	1.7	-1.8	-1.9
Bone: maximum diameter	0.1	0.2	0.3	-0.4	0.5	0.5	-0.3	-0.4
Bone: maximum force	0.1	0.1	0.3	-0.1	0.3	0.5	-0.1	-0.3
Bone: maximum moment	0.0	0.0	0.1	0.1	0.0	0.3	0.1	-0.1
Bone: minimum diameter	0.3	0.6	0.8	0.9	-0.6	-0.7	0.9	0.7
Bone: periosteal estimation	0.4	0.8	1.4	-0.8	1.2	0.9	-0.8	-0.9
Bone: periosteal perimeter	0.0	0.0	0.1	-0.0	0.1	0.4	-0.0	-0.2
Bone: post-yield work	1.8	2.5	2.9	1.7	-1.6	-1.4	1.6	1.6
Bone: stiffness	0.9	1.4	1.9	1.4	-1.1	-0.8	1.4	1.2
Bone: tissue strength	0.5	0.5	0.7	-0.6	0.6	0.9	-0.7	-0.8
Bone: trabecular number	0.3	0.4	0.5	0.6	-0.6	-0.4	0.7	0.7
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	0.2	0.0	-0.4	-0.1
Bone: trabecular thickness	0.0	0.0	0.1	0.2	-0.2	-0.1	0.2	0.2
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	-0.1	-0.1	0.0	0.0
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.2	-0.4	0.3	0.2	0.1
Distance traveled before self-admin	0.9	0.9	1.0	-1.0	1.0	1.0	-0.9	-0.9
Distance traveled after self-admin	0.1	0.1	0.2	0.3	0.0	-0.5	0.2	0.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.1	0.3	-0.1
Delta time in open arm before/after self-admin	1.3	1.3	1.6	1.0	-1.1	-1.1	1.1	1.3
Diff in mean of infusions in LGA sessions	1.0	1.1	1.8	1.1	-1.4	-0.4	1.1	1.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.2	-0.1	-0.0	0.0	0.2
Active lever presses in extinction session 6	1.5	1.5	1.7	1.2	-1.1	-1.3	1.1	1.3
Delta distance traveled before/after self-admin	0.4	0.4	0.7	0.6	-0.5	-0.8	0.6	0.7
Delta ambulatory time before/after self-admin	1.0	1.1	1.9	1.0	-0.8	-1.4	0.9	1.2
Time in closed arm before self-admin	8.4	9.5	10.4	-3.2	3.2	2.9	-3.1	-3.0
Time in closed arm after self-admin	7.7	8.0	9.7	-2.9	3.1	2.3	-2.8	-3.0
Time in open arm before self-admin	6.2	6.6	7.0	2.6	-2.5	-2.6	2.6	2.5
Time in open arm after self-admin	11.2	12.4	14.2	3.5	-3.8	-3.1	3.6	3.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	0.2	0.7	-0.4	-0.4
Time to tail flick, vehicle, before self-admin	3.0	3.0	4.1	1.6	-1.8	-1.6	1.6	2.0
Time to tail flick, vehicle, after self-admin	1.0	1.0	1.6	0.9	-1.3	-0.7	1.1	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.3	0.5	-0.0	-0.4	-0.0
Time to tail flick, test, after self-admin	5.0	5.1	6.6	2.2	-2.6	-1.9	2.4	2.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.4	-0.5	-0.1	0.5	0.3
Delta time to tail flick, test, before/after SA	5.0	4.5	5.9	2.1	-2.4	-1.7	2.3	1.9
Ambulatory time before self-admin	1.1	1.2	1.7	-1.0	1.0	1.3	-1.0	-1.2
Ambulatory time after self-admin	0.1	0.2	0.3	-0.4	0.5	0.3	-0.4	-0.3
Total heroin consumption	2.7	3.2	4.3	1.9	-2.1	-1.4	2.0	1.6
Area under the delay curve	1.2	1.3	2.3	-1.3	1.5	0.6	-1.1	-0.9
Delay disc. indifference point, 0s delay	0.4	0.5	0.6	0.6	-0.6	-0.8	0.8	0.8
Delay disc. indifference point, 16s delay	1.4	1.4	2.5	-1.2	1.6	0.8	-1.2	-1.0
Delay disc. indifference point, 2s delay	3.8	4.3	6.3	-2.2	2.5	1.4	-2.1	-2.0
Delay disc. indifference point, 24s delay	1.2	1.1	1.7	-1.1	1.3	0.7	-1.1	-1.0
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.8	1.1	0.0	-0.6	-0.6
Delay disc. indifference point, 8s delay	0.4	0.4	0.8	-0.9	0.9	0.3	-0.6	-0.5
Delay discount exponential model param	1.0	1.0	1.9	1.1	-1.4	-0.5	1.0	0.8
Delay discount hyperbolic model param	1.3	1.3	2.4	1.3	-1.6	-0.6	1.2	1.0
Fecal boli incidents, locomotor time 1	0.3	0.3	0.9	-0.3	-0.0	0.9	-0.3	-0.6
Change in fecal boli incidents, locomotor task	1.4	1.4	1.9	1.2	-1.0	-1.4	1.1	1.2
Time >=10cm from walls, locomotor time 1	3.0	3.1	5.4	1.9	-2.3	-0.8	1.9	1.5
Bouts of movement, locomotor time 1	1.0	1.1	1.5	-1.2	1.0	1.1	-1.1	-0.9
Total resting periods, locomotor time 1	1.2	1.3	1.6	-1.3	1.1	1.1	-1.2	-1.0
Rest time, locomotor task time 1	0.4	0.4	0.7	-0.7	0.9	0.2	-0.7	-0.6
Distance moved, locomotor task time 1	1.1	1.2	1.4	-1.0	1.2	1.0	-1.1	-1.2
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.4	0.5	0.2	-0.2	-0.6
Time >=10cm from walls, locomotor time 2	3.0	3.2	4.1	1.8	-2.0	-1.3	1.9	1.8
Bouts of movement, locomotor time 2	0.2	0.2	0.7	-0.1	0.7	-0.8	-0.2	0.0
Total resting periods, locomotor time 2	0.2	0.3	0.7	-0.2	0.8	-0.6	-0.4	-0.1
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	0.5	-0.2	-0.4	-0.3
Distance moved, locomotor task time 2	0.3	0.4	0.7	-0.6	0.6	0.8	-0.6	-0.6
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	-0.3	-0.1	0.3	0.1
Weight adjusted by age	0.2	0.2	0.3	0.6	-0.2	-0.5	0.4	0.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.6	0.8	-0.6	-0.8	0.6	0.5
Locomotion in novel chamber	2.7	3.3	5.3	1.8	-1.4	-2.3	1.8	1.7
Locomotion in novel chamber post-restriction	0.3	0.3	0.4	-0.7	0.6	0.4	-0.4	-0.7
Progressive ratio	1.8	2.1	3.6	-1.4	1.9	0.6	-1.4	-1.5
Food seeking constrained by brief footshock	0.1	0.2	0.6	0.1	0.1	-0.8	0.1	0.4
Seeking ratio, punishment vs. effort	1.3	1.6	2.3	1.2	-1.4	-1.0	1.2	1.5
Run reversals in cocaine runway, females	3.0	2.9	3.4	-1.8	1.8	1.5	-1.8	-1.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	0.3	0.1	-0.3	-0.3
Latency to leave start box in cocaine runway	0.8	0.8	1.2	-1.0	1.1	0.7	-1.0	-0.8
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	-0.5	0.4	0.7	-0.5	-0.6
Latency to leave start box in cocaine runway, M	0.6	0.5	1.0	-0.8	1.0	0.4	-0.8	-0.4
Cd content in liver	0.5	0.5	0.7	0.7	-0.4	-0.9	0.7	0.8
Co content in liver	1.5	1.8	3.1	1.2	-0.9	-1.8	1.3	1.3
Cu content in liver	2.3	2.8	3.4	-1.7	1.7	1.4	-1.7	-1.8
Fe content in liver	1.3	1.5	1.9	-1.2	1.2	1.4	-1.2	-1.3
K content in liver	1.2	1.2	1.5	1.1	-1.2	-1.1	1.1	0.9
Mg content in liver	0.1	0.1	0.2	0.3	-0.3	-0.5	0.3	0.2
Mn content in liver	0.1	0.1	0.1	0.3	-0.2	-0.3	0.2	0.2
Na content in liver	0.0	0.0	0.1	-0.0	-0.3	0.1	0.0	0.0
Rb content in liver	0.3	0.4	0.7	0.6	-0.2	-0.8	0.6	0.5
Se content in liver	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.1
Sr content in liver	0.1	0.1	0.3	-0.0	0.5	0.2	-0.0	-0.1
Zn content in liver	0.0	0.0	0.1	-0.2	0.3	-0.3	-0.1	-0.0