Rbm4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	ENSRNOG00000061795	0.22	0.14	9.6e-03	0.09	0.07	0.06	0.07	4.2e-03	1.0e-02	2.0e-02	8.6e-03
2	Liver	gene expression	ENSRNOG00000061795	0.04	0.03	1.4e-03	0.02	0	0	0	2.3e-03	2.9e-01	2.6e-01	1.4e-01
3	Liver	intron excision ratio	chr1:202049074:202054060	0.04	0.03	3.8e-03	0	0	0	-0	3.7e-01	1.7e-01	2.3e-01	7.9e-01
4	Liver	intron excision ratio	chr1:202054730:202057424	0.04	0.03	4.4e-03	0	0	0	0	2.1e-01	8.2e-02	2.3e-01	3.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
BMI with tail	4.6	14.8	18.9	-4.3	-2.5	4.1	-4.2
BMI without tail	1.9	3.9	5.8	-2.4	-1.2	2.0	-2.1
Body weight	3.1	13.2	16.7	-2.4	-3.7	4.1	-4.0
Epididymis fat weight	1.6	3.7	5.5	0.4	2.3	-2.2	2.1
Glucose	0.8	1.2	3.0	-1.0	1.7	-0.7	0.6
Heart weight	1.2	1.8	2.6	0.0	1.5	-1.6	1.5
Left kidney weight	0.9	2.6	3.1	1.5	1.4	-1.7	1.8
Right kidney weight	0.6	1.8	3.3	1.8	0.7	-1.2	1.3
Tail length	0.3	0.8	2.2	1.5	-0.9	-0.0	0.1
Length with tail	1.0	3.6	7.7	0.5	-2.8	1.9	-1.7
Length without tail	1.7	3.8	5.8	-0.5	-2.4	2.2	-2.1
Liver weight, left	0.2	0.3	0.4	0.4	0.4	-0.6	0.6
Liver weight, right	0.1	0.2	0.4	0.1	0.7	-0.5	0.4
Parametrial fat weight	1.1	2.2	4.4	-0.5	2.1	-1.5	1.4
Retroperitoneal fat weight	3.4	11.2	18.6	0.8	4.3	-3.6	3.5
Intraocular pressure	1.4	1.9	2.7	1.6	1.1	-1.4	1.4
Extensor digitorum longus weight	5.4	21.7	32.4	-2.0	-5.7	5.1	-4.9
Soleus weight	4.5	13.2	18.7	2.2	4.3	-3.8	3.8
Tibialis anterior weight	6.0	20.8	41.4	-0.3	-6.4	4.7	-4.5
Tibia length	0.4	1.0	1.7	1.1	-1.3	0.9	-0.7
Number of licking bursts	0.3	0.3	0.4	-0.3	-0.5	0.7	-0.6
Food consumed during 24 hour testing period	0.2	0.2	0.7	0.8	0.3	-0.2	0.2
Times rat made contact with spout	0.8	1.0	1.2	-1.1	-0.7	1.1	-1.1
Mean time between licks in bursts	0.1	0.1	0.2	-0.3	-0.5	0.4	-0.4
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	0.4	-0.2	0.1
Std. dev. time between licks in bursts	0.4	0.5	0.7	0.8	0.3	-0.8	0.8
Water consumed over 24 hours	0.7	0.8	1.1	-0.7	-0.7	1.1	-1.1
Indifference point 0 sec	0.0	0.1	0.1	-0.3	0.3	-0.0	-0.0
Indifference point AUC	2.5	3.0	4.7	-0.6	-2.2	1.9	-1.8
Indifference point function ln k	7.5	10.6	14.0	1.7	3.7	-3.6	3.5
Indifference point function log k	7.5	10.6	14.0	1.7	3.7	-3.6	3.5
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	0.1	0.2	-0.2	0.2
Delay discounting total patch changes 12 sec	4.3	5.8	7.2	-1.6	-2.5	2.7	-2.6
Delay discounting total patch changes 18 sec	1.0	1.3	1.4	-1.1	-1.1	1.2	-1.2
Delay discounting total patch changes 24 sec	1.3	1.6	2.1	-0.6	-1.4	1.4	-1.4
Delay discounting total patch changes 6 sec	1.7	2.6	3.0	-1.4	-1.4	1.7	-1.7
Delay discounting time to switch 0 sec	3.6	5.5	7.1	-2.3	-1.7	2.6	-2.7
Delay discounting water rate 0 sec	6.5	10.4	12.6	3.0	2.8	-3.5	3.5
Delay discounting water rate 12 sec	11.0	16.4	20.5	3.0	4.0	-4.5	4.5
Delay discounting water rate 18 sec	3.9	5.1	7.0	1.4	2.6	-2.4	2.4
Delay discounting water rate 24 sec	6.3	8.6	10.5	2.5	2.8	-3.2	3.2
Delay discounting water rate 6 sec	5.2	7.6	9.2	2.2	2.7	-3.0	3.0
Locomotor activity	2.2	3.5	4.6	1.4	1.6	-2.2	2.1
Locomotor testing distance	2.8	4.6	6.2	1.4	2.1	-2.5	2.4
Locomotor testing rearing	1.2	1.9	2.7	0.1	1.6	-1.6	1.5
Light reinforcement 1	0.2	0.4	0.5	0.3	0.6	-0.7	0.7
Light reinforcement 2	1.2	1.6	1.9	1.4	1.1	-1.2	1.3
Reaction time number correct	0.2	0.3	0.6	0.8	-0.8	0.0	0.0
Reaction time mean minus median	2.9	3.8	5.6	-0.9	-2.4	2.2	-2.1
Reaction time mean minus median AUC	1.4	1.8	4.1	-0.1	-2.0	1.3	-1.2
Reaction time num false alarms	0.6	0.8	1.0	0.9	0.7	-1.0	1.0
Reaction time num false alarms AUC	0.1	0.1	0.3	0.6	-0.1	-0.3	0.3
Reaction time trials correct on left	0.2	0.3	0.6	0.8	-0.8	0.0	0.0
Reaction time trials on left	0.3	0.4	0.8	0.8	-0.9	0.1	-0.0
Reaction time mean	0.0	0.1	0.1	-0.0	-0.4	0.2	-0.2
Reaction time mean AUC	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2
Median of all reaction times	0.0	0.0	0.0	-0.0	0.1	-0.2	0.2
Reaction time omissions	1.2	1.6	3.1	-0.2	-1.8	1.3	-1.2
Reaction time false alarm rate	0.2	0.3	0.4	0.4	0.6	-0.6	0.5
Reaction time premature initiation rate	0.9	1.2	1.7	-0.4	-1.3	1.2	-1.2
Reaction time premature initiations	1.4	1.9	3.9	0.1	-2.0	1.4	-1.3
Std. dev. reaction times	0.8	1.0	1.7	-0.3	-1.3	1.1	-1.1
Reaction time trials completed	0.3	0.4	0.8	0.8	-0.9	0.1	-0.0
Reaction time trials AUC	0.2	0.3	0.5	0.7	-0.7	-0.0	0.1
Social response proportion	1.2	1.2	1.8	-1.0	-0.6	1.3	-1.3
Social responses	0.2	0.2	0.3	-0.3	-0.3	0.6	-0.6
Social time	0.1	0.2	0.3	-0.2	-0.4	0.5	-0.5
Conditioned locomotion	0.8	0.9	2.3	0.3	-1.5	0.9	-0.8
Cocaine response after cond. corrected	0.8	0.9	1.3	0.4	1.1	-1.1	1.1
Cocaine response after cond. not corrected	0.5	0.6	1.1	0.0	1.0	-0.9	0.8
Cocaine response before conditioning	0.6	0.7	1.0	-0.6	-0.8	1.0	-1.0
Saline control response	3.1	4.1	5.3	-1.5	-2.0	2.3	-2.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.6	0.6	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	0.1	1.0	-0.5	0.5
Condit. Reinf. active responses	0.9	1.2	2.7	-1.7	-0.1	1.0	-1.1
Condit. Reinf. inactive responses	2.0	2.5	4.7	-2.2	-0.8	1.5	-1.6
Condit. Reinf. lever presses	2.8	3.8	5.0	-1.3	-1.9	2.2	-2.2
Condit. Reinf. lever reinforcers received	1.1	1.6	2.6	-1.6	-0.5	1.3	-1.3
Pavlov. Cond. lever latency	0.5	0.7	1.0	0.4	0.8	-1.0	1.0
Pavlov. Cond. magazine entry latency	4.7	5.4	7.0	-1.7	-2.2	2.6	-2.6
Pavlov. Cond. change in total contacts	2.3	3.2	4.6	-1.2	-1.6	2.2	-2.1
Pavlov. Cond. index score	2.6	3.4	4.9	-1.1	-1.7	2.2	-2.2
Pavlov. Cond. latency score	2.1	2.7	3.9	-1.0	-1.5	2.0	-1.9
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.1	-0.7	0.8	-0.7
Pavlov. Cond. magazine entry number	7.2	8.8	11.4	2.0	3.0	-3.4	3.3
Pavlov. Cond. intertrial magazine entries	1.1	1.4	1.9	0.7	1.2	-1.4	1.3
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	5.7	-1.3	-1.9	2.4	-2.3
Pavlov. Cond. response bias	1.8	2.5	3.3	-0.9	-1.6	1.8	-1.8
Conditioned reinforcement - actives	0.3	0.3	0.4	0.4	0.6	-0.6	0.6
Conditioned reinforcement - inactives	4.1	4.7	5.9	1.3	2.3	-2.4	2.4
Conditioned locomotion	8.6	10.4	12.7	2.2	3.4	-3.6	3.5
Intermittent access intake day 1-15 change	1.0	0.9	1.6	1.2	0.4	-1.0	1.1
Intermittent access intake escalation	0.5	0.5	0.7	0.8	0.4	-0.8	0.8
Intermittent access intake escalation 2	0.7	0.7	1.2	1.1	0.2	-0.9	0.9
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.7	1.0	1.3	-1.2	1.2
Intermitt. access day 15 inactive lever presses	1.1	1.3	2.1	0.8	1.4	-1.1	1.1
Intermitt. access escalation Index	2.3	2.1	4.4	-0.2	2.1	-1.5	1.3
Intermittent access day 1 total infusions	1.8	2.0	4.4	-1.5	2.1	-0.9	0.8
Intermittent access day 15 total infusions	3.2	3.6	6.1	0.1	2.5	-2.1	2.0
Intermittent access terminal intake (last 3 days)	1.7	1.9	3.4	-0.3	1.8	-1.5	1.4
Intermittent access total infusions	1.2	1.4	2.9	-1.1	1.7	-0.8	0.7
Intermittent access day 1 locomotion	1.3	1.3	2.6	-1.6	1.6	-0.4	0.2
Intermittent access day 15 total locomotion	1.9	2.0	4.1	-0.1	2.0	-1.4	1.3
Intermittent access total locomotion	2.1	2.4	6.0	-1.1	2.4	-1.1	1.0
Intermittent access standard deviation	0.7	0.8	1.2	0.7	0.5	-1.1	1.1
Cocaine induced anxiety	0.1	0.1	0.1	0.4	-0.3	-0.1	0.2
Post-drug Anxiety	0.8	0.8	1.9	0.7	-1.4	0.7	-0.6
Baseline Anxiety	1.1	1.1	1.9	0.1	-1.4	1.2	-1.1
Lifetime Intake	1.2	1.3	2.7	-1.3	1.6	-0.7	0.6
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.5	0.3	-0.1	0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.5	-0.3	0.3
Progressive ratio test 1 active lever presses	1.1	1.1	1.9	-0.0	1.4	-1.1	1.1
Progressive ratio test 1 breakpoint	1.0	1.0	1.5	0.1	1.2	-1.2	1.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.9	-0.2	0.9	-0.6	0.6
Progressive ratio test 2 active lever presses	1.5	1.6	2.9	-0.0	1.7	-1.4	1.3
Progressive ratio test 2 breakpoint	2.6	2.9	4.1	0.5	2.0	-1.9	1.9
Progressive ratio test 2 inactive lever presses	3.8	4.4	7.9	0.2	2.8	-2.2	2.1
Total sessions with >9 infusions	0.5	0.6	1.3	-0.8	1.1	-0.5	0.4
Short access day 1 total inactive lever presses	2.0	2.3	3.4	0.3	1.9	-1.7	1.6
Short access day 10 total inactive lever presses	2.2	2.4	3.2	1.1	1.5	-1.8	1.7
Short access day 1 total infusions	1.1	1.2	2.8	-1.1	1.7	-0.7	0.6
Short access day 10 total infusions	1.8	1.9	6.5	-2.6	0.5	0.6	-0.8
Short access total infusions	0.8	0.8	2.5	-1.6	0.9	0.0	-0.1
Short access day 1 locomotion	0.8	0.9	1.9	-1.3	1.4	-0.2	0.1
Short access day 10 total locomotion	0.6	0.7	1.6	-1.3	1.1	-0.0	-0.1
Short access total locomotion	0.6	0.6	1.7	-1.3	0.9	0.0	-0.1
Compulsive drug intake	0.8	0.8	1.2	-0.1	-1.0	1.1	-1.1
One hour access (0.3 mA shock)	5.3	6.2	11.1	0.4	3.3	-2.6	2.5
One hour access (shock baseline)	4.1	4.7	6.8	0.5	2.6	-2.5	2.4
Number of responses in last shaping day	1.0	1.0	1.3	0.7	0.9	-1.2	1.1
Context. condit. distance diff. score	1.4	1.8	2.9	0.3	1.7	-1.4	1.4
Locomotion velocity, session 1	0.2	0.2	0.2	0.5	0.2	-0.4	0.5
Locomotion distance, session 1	1.4	1.8	3.3	-1.8	-0.3	1.4	-1.4
Locomotion velocity, session 2	2.4	2.8	3.5	-1.1	-1.8	1.9	-1.9
Locomotion distance, session 2	1.2	1.7	2.2	-1.4	-0.6	1.4	-1.5
Locomotion velocity, session 3	0.2	0.2	0.5	-0.7	0.4	0.2	-0.2
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	0.2	-0.1	0.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.0	-0.7	1.0	-0.4	0.3
Stereotopy head waving duration, day 3	0.5	0.6	1.4	-0.4	1.2	-0.6	0.6
Locomotion velocity, session 7	0.3	0.3	0.9	-1.0	0.3	0.2	-0.2
Locomotion distance, session 7	0.1	0.1	0.4	-0.7	-0.1	0.2	-0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.6	0.3	0.2	-0.2
Stereotopy head waving duration, day 7	2.0	2.5	3.0	-1.6	-1.2	1.7	-1.7
Locomotion velocity, session 8	0.3	0.3	0.5	-0.1	-0.5	0.7	-0.7
Locomotion distance, session 8	0.2	0.4	1.1	-0.4	1.1	-0.3	0.2
Degree of sensitization distance	0.3	0.3	0.7	-0.8	-0.2	0.4	-0.5
Degree of sensitization stereotypy	0.9	1.0	1.2	-0.8	-1.0	1.1	-1.1
Condit. Reinf. active minus inactive responses	0.4	0.4	0.6	-0.7	-0.5	0.7	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.1	0.4	-0.4
Condit. Reinf. active responses	0.2	0.2	0.3	-0.4	-0.5	0.6	-0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.1
Incentive salience index mean	0.6	0.7	0.9	-0.8	-0.5	0.9	-0.9
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.0	-0.4	0.6	-0.6
Time in familiar zone, hab. session 1	0.2	0.2	0.5	-0.5	0.7	-0.0	-0.0
Time in novel zone, hab. session 1	0.5	0.5	0.7	0.7	0.1	-0.8	0.8
Total zone transitions, hab. session 1	0.8	1.1	1.3	-0.8	-1.0	1.1	-1.1
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.1	0.5	-0.5	0.5
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.2	0.1	-0.0	0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	-0.0	-0.4	0.4
Time in novel zone, hab. session 2	0.5	0.5	0.9	-0.9	-0.2	0.7	-0.7
Total zone transitions, hab. session 2	4.4	5.7	9.8	-3.1	-1.1	2.4	-2.5
Total locomotion distance, hab. session 2	0.8	1.1	3.1	-1.8	0.2	0.7	-0.8
Locomotion velocity, hab. session 2	0.6	0.9	2.6	-1.6	0.5	0.5	-0.6
Novel to familiar place preference ratio	1.2	1.3	1.7	-0.8	-1.1	1.3	-1.3
Novelty place preference	0.7	0.7	1.0	-0.7	-0.7	1.0	-1.0
Time in novel zone, NPP test	0.6	0.6	0.8	-0.7	-0.6	0.9	-0.9
Total zone transitions, NPP test	2.1	2.9	3.9	-1.6	-1.2	2.0	-2.0
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.7	0.2	0.4	-0.4
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.6	0.2	0.4	-0.4
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.4	-0.5	0.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.6	-1.3	-0.2	0.8	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.3	0.1	0.4	-0.4
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	0.5	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.7	0.2	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.3	-0.3	0.5	-0.5
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.2	0.2	-0.2
Bone: apparent density	2.5	4.1	7.2	-2.7	-1.0	2.0	-2.1
Bone surface	6.0	10.5	12.7	-2.8	-2.9	3.6	-3.6
Bone volume	3.2	5.4	6.5	-2.4	-1.7	2.5	-2.5
Bone: connectivity density	4.9	7.7	9.1	-3.0	-2.0	3.0	-3.0
Bone: cortical apparent density	0.1	0.1	0.2	0.1	-0.4	0.3	-0.3
Bone: cortical area	0.4	0.6	1.4	0.4	-1.2	0.7	-0.6
Bone: cortical porosity	0.5	0.6	1.2	-1.1	0.0	0.7	-0.8
Bone: cortical porosity	0.9	0.9	1.2	-1.1	-0.6	1.0	-1.0
Bone: cortical thickness	1.6	2.6	6.8	0.9	-2.6	1.3	-1.1
Bone: cortical thickness	0.3	0.4	0.8	0.8	-0.9	0.2	-0.1
Bone: cortical tissue density	0.1	0.1	0.3	0.1	-0.5	0.3	-0.3
Bone: elastic displacement	2.1	2.4	2.9	1.7	1.1	-1.6	1.7
Bone: elastic work	0.2	0.3	0.6	0.7	-0.8	0.2	-0.2
Bone: endosteal estimation	0.4	0.9	2.2	-1.0	1.5	-0.5	0.4
Bone: endosteal perimeter	0.6	1.3	3.8	-1.2	1.9	-0.4	0.3
Bone: final force	2.0	3.2	4.4	-0.9	-2.1	2.0	-1.9
Bone: final moment	1.7	2.8	3.6	-0.8	-1.9	1.9	-1.8
Bone: marrow area	0.4	1.0	2.4	-1.0	1.5	-0.6	0.5
Bone: maximum diameter	0.0	0.1	0.2	0.4	-0.2	0.2	-0.1
Bone: maximum force	3.7	6.4	8.2	-2.0	-2.3	2.9	-2.8
Bone: maximum moment	3.1	5.4	7.1	-1.9	-2.0	2.7	-2.6
Bone: minimum diameter	0.4	0.8	2.2	-1.5	1.0	0.1	-0.2
Bone: periosteal estimation	0.0	0.0	0.0	-0.1	0.0	0.1	-0.1
Bone: periosteal perimeter	0.2	0.3	0.5	-0.7	-0.1	0.7	-0.7
Bone: post-yield work	4.4	5.9	11.5	-3.4	-0.4	2.4	-2.5
Bone: stiffness	3.6	5.6	6.8	-2.0	-2.2	2.6	-2.6
Bone: tissue strength	0.1	0.1	0.2	-0.4	-0.1	0.4	-0.4
Bone: trabecular number	2.5	3.9	5.6	-2.4	-1.2	2.1	-2.1
Bone: trabecular spacing	0.7	0.8	1.0	0.8	1.0	-1.0	1.0
Bone: trabecular thickness	0.5	0.6	1.8	-1.3	0.5	0.3	-0.4
Bone: trabecular tissue density	4.4	6.1	7.2	2.1	2.4	-2.7	2.7
Breakpoint value in progressive ratio session	2.5	2.8	3.8	-0.7	-1.9	1.9	-1.8
Distance traveled before self-admin	0.3	0.3	0.5	-0.1	-0.7	0.6	-0.5
Distance traveled after self-admin	0.1	0.1	0.3	0.1	-0.6	0.4	-0.3
Delta time in closed arm before/after self-admin	0.3	0.3	1.0	-0.2	-1.0	0.1	-0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.5	-0.3	-0.0	0.0
Diff in mean of infusions in LGA sessions	0.4	0.4	1.1	0.3	-1.1	0.5	-0.4
Extinction: sum of active levers before priming	4.1	4.2	5.9	-1.5	-1.7	2.4	-2.4
Active lever presses in extinction session 6	1.6	1.6	4.3	0.7	-2.1	0.9	-0.8
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1
Time in closed arm before self-admin	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2
Time in closed arm after self-admin	0.1	0.1	0.3	-0.0	-0.5	0.0	-0.1
Time in open arm before self-admin	0.3	0.3	0.4	-0.3	0.6	-0.6	0.6
Time in open arm after self-admin	0.3	0.4	0.5	0.7	0.2	-0.7	0.7
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.2	1.5	-1.1	0.3	-0.2
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.0	-0.9	-1.0	1.0	-1.0
Time to tail flick, vehicle, after self-admin	2.2	2.4	2.5	-1.5	-1.6	1.6	-1.6
Time to tail flick, test, before self-admin	0.5	0.5	1.6	-1.3	0.6	0.1	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	-0.2	0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.0	-1.0	-0.7	1.0	-1.0
Delta time to tail flick, test, before/after SA	0.9	0.8	2.1	1.4	-1.1	0.0	0.1
Ambulatory time before self-admin	0.3	0.3	0.4	0.1	-0.6	0.7	-0.6
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.2
Total heroin consumption	3.0	3.6	5.3	-0.7	-1.9	2.3	-2.2
Area under the delay curve	0.5	0.6	1.1	-1.1	1.0	0.2	-0.3
Delay disc. indifference point, 0s delay	0.8	0.8	1.9	-1.1	1.4	-0.4	0.3
Delay disc. indifference point, 16s delay	0.4	0.4	1.4	-0.4	1.2	-0.3	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.5	-0.0	0.7	-0.2	0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	0.3	-0.4	0.4
Delay disc. indifference point, 4s delay	0.4	0.4	1.1	-0.8	1.1	-0.1	-0.0
Delay disc. indifference point, 8s delay	0.4	0.4	0.8	-0.9	0.8	0.1	-0.2
Delay discount exponential model param	0.4	0.4	1.0	1.0	-0.8	-0.2	0.3
Delay discount hyperbolic model param	0.4	0.4	0.8	0.9	-0.8	-0.2	0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.5	-0.4	0.1	-0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.3	-1.1	-0.0	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.4	-1.6	0.6	0.2	-0.2
Bouts of movement, locomotor time 1	0.9	1.0	1.5	-0.1	-1.2	1.2	-1.1
Total resting periods, locomotor time 1	0.7	0.8	1.2	-0.2	-0.9	1.1	-1.0
Rest time, locomotor task time 1	2.2	2.4	2.6	1.6	1.4	-1.6	1.6
Distance moved, locomotor task time 1	1.0	1.1	2.1	-1.5	-0.5	1.0	-1.0
Vertical activity count, locomotor time 1	0.7	0.7	1.0	0.1	1.0	-1.0	0.9
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.4	0.2	0.0	-0.0
Bouts of movement, locomotor time 2	0.6	0.7	0.9	-0.5	-0.8	0.9	-0.9
Total resting periods, locomotor time 2	0.4	0.5	0.6	-0.5	-0.6	0.8	-0.8
Rest time, locomotor task time 2	2.0	2.3	3.1	1.0	1.8	-1.6	1.6
Distance moved, locomotor task time 2	0.7	0.8	1.1	-0.5	-1.1	1.0	-1.0
Vertical activity count, locomotor time 2	0.4	0.4	0.7	0.8	-0.1	-0.7	0.7
Weight adjusted by age	1.9	2.1	4.0	-0.5	-2.0	1.5	-1.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.0	-1.0	0.3	0.5	-0.6
Locomotion in novel chamber	3.9	4.8	7.0	1.0	2.7	-2.4	2.4
Locomotion in novel chamber post-restriction	2.1	2.4	3.5	0.7	1.6	-1.9	1.8
Progressive ratio	4.4	5.1	6.0	-2.4	-1.6	2.4	-2.4
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.2	-0.5	0.4	-0.4
Seeking ratio, punishment vs. effort	3.1	3.8	4.6	1.9	1.6	-2.1	2.1
Run reversals in cocaine runway, females	1.8	1.8	3.4	-1.8	-0.8	1.2	-1.3
Run reversals in cocaine runway, males	1.9	1.9	3.9	2.0	-0.2	-1.3	1.4
Latency to leave start box in cocaine runway	0.3	0.3	0.5	-0.7	-0.1	0.6	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	-0.8	-0.0	0.5	-0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.0	-0.4	0.2	-0.2
Cd content in liver	1.6	1.8	2.4	1.3	0.8	-1.5	1.5
Co content in liver	2.4	2.9	3.8	1.5	1.3	-1.9	1.9
Cu content in liver	0.4	0.5	0.7	-0.6	-0.5	0.8	-0.8
Fe content in liver	0.0	0.1	0.1	0.3	-0.3	0.1	-0.1
K content in liver	3.0	3.0	4.1	-1.8	-1.0	2.0	-2.0
Mg content in liver	2.5	2.6	5.6	-2.4	-0.0	1.5	-1.6
Mn content in liver	2.4	2.8	3.7	-0.9	-1.8	1.9	-1.9
Na content in liver	0.2	0.2	0.4	0.7	-0.4	0.4	-0.3
Rb content in liver	0.5	0.6	1.1	-1.0	1.0	-0.5	0.4
Se content in liver	0.4	0.4	0.7	-0.8	-0.2	0.7	-0.7
Sr content in liver	1.5	1.4	3.4	0.6	-1.8	1.0	-0.9
Zn content in liver	1.1	1.2	1.7	-0.6	-1.1	1.3	-1.3