Hub : Genes

Pag1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000061328 0.06 0.05 7.3e-03 0.01 -0 -0 -0 1.2e-01 9e-01 1e+00 6.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
BMI with tail2.58.18.1-2.8
BMI without tail6.012.512.5-3.5
Body weight0.62.72.7-1.7
Epididymis fat weight0.00.00.00.2
Glucose1.82.72.7-1.6
Heart weight1.92.72.71.6
Left kidney weight0.92.62.61.6
Right kidney weight0.41.11.11.1
Tail length0.41.11.1-1.1
Length with tail0.00.10.10.4
Length without tail1.12.52.51.6
Liver weight, left2.23.63.6-1.9
Liver weight, right0.30.50.5-0.7
Parametrial fat weight0.10.20.2-0.5
Retroperitoneal fat weight0.00.10.10.4
Intraocular pressure2.23.03.0-1.7
Extensor digitorum longus weight10.441.641.6-6.4
Soleus weight1.02.92.9-1.7
Tibialis anterior weight8.428.828.8-5.4
Tibia length1.74.84.82.2
Number of licking bursts0.40.50.50.7
Food consumed during 24 hour testing period2.22.62.6-1.6
Times rat made contact with spout0.00.00.00.2
Mean time between licks in bursts0.81.11.1-1.1
Mean num. licks in bursts0.20.30.3-0.5
Std. dev. time between licks in bursts0.00.00.00.1
Water consumed over 24 hours0.10.20.2-0.4
Indifference point 0 sec1.01.61.61.2
Indifference point AUC0.80.90.9-0.9
Indifference point function ln k0.00.00.00.1
Indifference point function log k0.00.00.00.1
Delay discounting total patch changes 0 sec0.50.80.80.9
Delay discounting total patch changes 12 sec0.20.30.30.6
Delay discounting total patch changes 18 sec0.71.01.0-1.0
Delay discounting total patch changes 24 sec0.10.10.10.3
Delay discounting total patch changes 6 sec0.00.00.0-0.1
Delay discounting time to switch 0 sec1.31.91.9-1.4
Delay discounting water rate 0 sec0.00.10.10.3
Delay discounting water rate 12 sec1.32.02.01.4
Delay discounting water rate 18 sec0.50.60.60.8
Delay discounting water rate 24 sec0.00.00.00.2
Delay discounting water rate 6 sec2.13.13.11.8
Locomotor activity0.00.00.00.0
Locomotor testing distance0.00.00.00.1
Locomotor testing rearing0.81.21.21.1
Light reinforcement 11.12.12.1-1.4
Light reinforcement 23.54.64.6-2.2
Reaction time number correct0.20.40.40.6
Reaction time mean minus median3.14.14.1-2.0
Reaction time mean minus median AUC4.35.55.5-2.3
Reaction time num false alarms0.91.21.21.1
Reaction time num false alarms AUC0.91.31.31.1
Reaction time trials correct on left0.20.40.40.6
Reaction time trials on left0.20.20.20.5
Reaction time mean2.43.33.3-1.8
Reaction time mean AUC2.73.73.7-1.9
Median of all reaction times2.02.72.7-1.6
Reaction time omissions5.57.57.5-2.7
Reaction time false alarm rate0.20.30.30.5
Reaction time premature initiation rate1.72.32.31.5
Reaction time premature initiations1.82.62.61.6
Std. dev. reaction times2.02.82.8-1.7
Reaction time trials completed0.20.20.20.5
Reaction time trials AUC0.10.20.20.4
Social response proportion0.20.20.2-0.5
Social responses0.81.01.0-1.0
Social time0.00.00.0-0.0
Conditioned locomotion0.20.30.3-0.5
Cocaine response after cond. corrected1.11.21.21.1
Cocaine response after cond. not corrected1.71.91.91.4
Cocaine response before conditioning0.10.10.10.4
Saline control response0.91.21.21.1
Condit. Reinf. active minus inactive responses1.72.12.11.4
Condit. Reinf. active-inactive response ratio0.60.70.70.8
Condit. Reinf. active responses2.53.43.41.9
Condit. Reinf. inactive responses0.30.40.40.6
Condit. Reinf. lever presses0.91.21.21.1
Condit. Reinf. lever reinforcers received2.73.83.82.0
Pavlov. Cond. lever latency1.41.91.9-1.4
Pavlov. Cond. magazine entry latency0.00.00.0-0.1
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.10.20.20.4
Pavlov. Cond. latency score0.20.30.30.6
Pavlov. Cond. lever contacts0.91.31.31.1
Pavlov. Cond. magazine entry number0.00.00.00.1
Pavlov. Cond. intertrial magazine entries0.10.20.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.30.5
Pavlov. Cond. response bias0.40.50.50.7
Conditioned reinforcement - actives4.44.34.32.1
Conditioned reinforcement - inactives0.00.00.00.2
Conditioned locomotion2.63.13.11.8
Intermittent access intake day 1-15 change5.95.95.92.4
Intermittent access intake escalation4.74.64.62.1
Intermittent access intake escalation 26.26.26.22.5
Intermitt. access day 1 inactive lever presses0.80.90.9-0.9
Intermitt. access day 15 inactive lever presses0.10.10.1-0.3
Intermitt. access escalation Index0.00.00.0-0.0
Intermittent access day 1 total infusions1.21.31.31.2
Intermittent access day 15 total infusions7.38.28.22.9
Intermittent access terminal intake (last 3 days)6.06.56.52.6
Intermittent access total infusions3.84.24.22.0
Intermittent access day 1 locomotion0.10.10.10.3
Intermittent access day 15 total locomotion0.40.40.40.7
Intermittent access total locomotion0.50.50.50.7
Intermittent access standard deviation5.35.65.62.4
Cocaine induced anxiety0.20.20.2-0.5
Post-drug Anxiety1.71.91.9-1.4
Baseline Anxiety0.00.00.0-0.0
Lifetime Intake3.53.93.92.0
Incentive Sensitization - Responses1.71.71.71.3
Incentive Sensitization - Breakpoint1.81.81.81.4
Progressive ratio test 1 active lever presses2.12.12.11.5
Progressive ratio test 1 breakpoint1.81.91.91.4
Progressive ratio test 1 inactive lever presses0.00.00.00.1
Progressive ratio test 2 active lever presses3.13.33.31.8
Progressive ratio test 2 breakpoint2.83.23.21.8
Progressive ratio test 2 inactive lever presses1.51.71.71.3
Total sessions with >9 infusions0.50.50.50.7
Short access day 1 total inactive lever presses0.20.30.30.5
Short access day 10 total inactive lever presses0.00.00.0-0.1
Short access day 1 total infusions1.61.71.71.3
Short access day 10 total infusions2.32.52.51.6
Short access total infusions2.12.42.41.5
Short access day 1 locomotion0.00.00.00.0
Short access day 10 total locomotion1.41.51.5-1.2
Short access total locomotion0.10.10.10.3
Compulsive drug intake0.90.90.9-0.9
One hour access (0.3 mA shock)5.86.76.72.6
One hour access (shock baseline)7.68.88.83.0
Number of responses in last shaping day0.00.00.0-0.2
Context. condit. distance diff. score0.00.00.00.2
Locomotion velocity, session 12.72.92.9-1.7
Locomotion distance, session 11.11.41.4-1.2
Locomotion velocity, session 22.63.13.1-1.8
Locomotion distance, session 21.72.42.4-1.6
Locomotion velocity, session 30.00.00.00.0
Locomotion distance, session 30.10.10.10.3
Stereotopy head waving bouts, day 30.10.10.1-0.3
Stereotopy head waving duration, day 30.40.50.5-0.7
Locomotion velocity, session 74.14.54.52.1
Locomotion distance, session 74.65.95.92.4
Stereotopy head waving bouts, day 70.60.70.7-0.8
Stereotopy head waving duration, day 71.31.61.6-1.3
Locomotion velocity, session 83.84.64.6-2.1
Locomotion distance, session 80.81.21.2-1.1
Degree of sensitization distance0.50.50.50.7
Degree of sensitization stereotypy2.12.22.2-1.5
Condit. Reinf. active minus inactive responses6.06.76.7-2.6
Condit. Reinf. active-inactive response ratio7.98.58.5-2.9
Condit. Reinf. active responses4.55.55.5-2.3
Condit. Reinf. inactive responses0.00.00.0-0.2
Incentive salience index mean6.17.37.3-2.7
Condit. Reinf. lever presses2.33.13.1-1.8
Time in familiar zone, hab. session 10.80.80.80.9
Time in novel zone, hab. session 10.20.20.2-0.4
Total zone transitions, hab. session 11.11.51.5-1.2
Total locomotion distance, hab. session 10.30.40.4-0.6
Locomotion velocity, hab. session 10.71.01.0-1.0
Time in familiar zone, hab. session 22.02.12.11.5
Time in novel zone, hab. session 20.70.70.7-0.9
Total zone transitions, hab. session 20.20.30.3-0.6
Total locomotion distance, hab. session 20.20.30.3-0.5
Locomotion velocity, hab. session 20.10.20.2-0.4
Novel to familiar place preference ratio0.00.00.0-0.1
Novelty place preference0.00.00.00.0
Time in novel zone, NPP test0.00.00.0-0.1
Total zone transitions, NPP test0.71.01.0-1.0
Total locomotion distance, NPP test0.40.50.5-0.7
Locomotion velocity, NPP test0.10.20.2-0.4
Pavlov. Cond. lever latency0.60.70.70.8
Pavlov. Cond. magazine entry latency0.30.40.4-0.7
Pavlov. Cond. change in total contacts2.72.92.9-1.7
Pavlov. Cond. index score0.91.11.1-1.0
Pavlov. Cond. latency score0.81.01.0-1.0
Pavlov. Cond. lever contacts0.60.70.7-0.8
Pavlov. Cond. magazine entry number0.91.11.11.1
Pavlov. Cond. intertrial magazine entries0.70.90.90.9
Pavlov. Cond. lever-magazine prob. diff.0.81.01.0-1.0
Pavlov. Cond. response bias0.70.80.8-0.9
Bone: apparent density1.42.32.31.5
Bone surface2.23.93.92.0
Bone volume1.93.23.21.8
Bone: connectivity density2.13.33.31.8
Bone: cortical apparent density0.81.01.0-1.0
Bone: cortical area0.00.00.0-0.1
Bone: cortical porosity0.00.00.0-0.1
Bone: cortical porosity0.10.10.1-0.3
Bone: cortical thickness0.30.50.5-0.7
Bone: cortical thickness4.25.05.0-2.2
Bone: cortical tissue density0.81.01.0-1.0
Bone: elastic displacement0.00.10.1-0.2
Bone: elastic work0.00.00.0-0.1
Bone: endosteal estimation0.40.80.80.9
Bone: endosteal perimeter0.61.11.11.1
Bone: final force0.10.10.1-0.3
Bone: final moment0.00.00.00.1
Bone: marrow area0.30.60.60.8
Bone: maximum diameter0.10.20.20.4
Bone: maximum force0.00.00.0-0.2
Bone: maximum moment0.10.10.10.3
Bone: minimum diameter0.20.50.5-0.7
Bone: periosteal estimation0.00.10.10.3
Bone: periosteal perimeter0.30.50.50.7
Bone: post-yield work3.44.74.72.2
Bone: stiffness0.00.10.1-0.2
Bone: tissue strength2.52.42.41.5
Bone: trabecular number0.81.31.31.1
Bone: trabecular spacing1.31.71.7-1.3
Bone: trabecular thickness1.72.12.11.4
Bone: trabecular tissue density3.14.34.3-2.1
Breakpoint value in progressive ratio session2.02.22.2-1.5
Distance traveled before self-admin0.30.30.30.5
Distance traveled after self-admin0.10.10.10.3
Delta time in closed arm before/after self-admin0.20.20.20.5
Delta time in open arm before/after self-admin0.00.00.00.0
Diff in mean of infusions in LGA sessions2.42.72.7-1.7
Extinction: sum of active levers before priming1.31.31.3-1.1
Active lever presses in extinction session 60.30.30.30.5
Delta distance traveled before/after self-admin0.40.40.40.6
Delta ambulatory time before/after self-admin1.01.11.11.0
Time in closed arm before self-admin0.50.60.60.8
Time in closed arm after self-admin0.50.50.50.7
Time in open arm before self-admin0.00.00.0-0.1
Time in open arm after self-admin1.31.51.5-1.2
Sum of active levers in priming session hrs 5-60.00.00.00.2
Time to tail flick, vehicle, before self-admin1.21.21.21.1
Time to tail flick, vehicle, after self-admin3.23.43.41.9
Time to tail flick, test, before self-admin0.00.00.00.0
Time to tail flick, test, after self-admin0.40.40.40.7
Delta time to tail flick, vehicle, before/after SA1.21.21.21.1
Delta time to tail flick, test, before/after SA0.00.00.0-0.0
Ambulatory time before self-admin0.10.10.10.4
Ambulatory time after self-admin0.50.50.50.7
Total heroin consumption0.10.10.1-0.3
Area under the delay curve1.11.11.1-1.1
Delay disc. indifference point, 0s delay0.10.10.10.3
Delay disc. indifference point, 16s delay1.31.31.3-1.1
Delay disc. indifference point, 2s delay0.40.40.4-0.7
Delay disc. indifference point, 24s delay0.10.10.1-0.3
Delay disc. indifference point, 4s delay1.91.91.9-1.4
Delay disc. indifference point, 8s delay0.10.10.1-0.3
Delay discount exponential model param0.80.80.80.9
Delay discount hyperbolic model param1.11.21.21.1
Fecal boli incidents, locomotor time 10.10.10.1-0.4
Change in fecal boli incidents, locomotor task2.82.72.71.6
Time >=10cm from walls, locomotor time 11.31.31.31.1
Bouts of movement, locomotor time 10.10.10.10.3
Total resting periods, locomotor time 10.10.10.10.4
Rest time, locomotor task time 10.30.30.30.6
Distance moved, locomotor task time 10.00.00.00.0
Vertical activity count, locomotor time 10.00.00.0-0.1
Time >=10cm from walls, locomotor time 20.30.30.30.5
Bouts of movement, locomotor time 20.20.20.2-0.4
Total resting periods, locomotor time 20.20.20.2-0.4
Rest time, locomotor task time 20.20.20.2-0.5
Distance moved, locomotor task time 20.00.00.00.1
Vertical activity count, locomotor time 21.01.11.1-1.0
Weight adjusted by age0.30.30.3-0.5
Seeking ratio, delayed vs. immediate footshock9.410.810.83.3
Locomotion in novel chamber1.21.51.5-1.2
Locomotion in novel chamber post-restriction0.00.00.00.1
Progressive ratio0.50.60.60.8
Food seeking constrained by brief footshock3.13.83.8-2.0
Seeking ratio, punishment vs. effort2.83.53.5-1.9
Run reversals in cocaine runway, females0.80.80.8-0.9
Run reversals in cocaine runway, males3.53.43.4-1.8
Latency to leave start box in cocaine runway0.80.90.90.9
Latency to leave start box in cocaine runway, F3.84.24.22.0
Latency to leave start box in cocaine runway, M2.52.42.4-1.6
Cd content in liver0.91.01.0-1.0
Co content in liver0.00.00.0-0.2
Cu content in liver3.94.74.72.2
Fe content in liver0.10.10.10.4
K content in liver1.01.01.01.0
Mg content in liver0.60.60.60.8
Mn content in liver0.10.10.1-0.2
Na content in liver1.11.11.11.1
Rb content in liver0.00.00.0-0.2
Se content in liver0.20.20.20.5
Sr content in liver0.10.10.1-0.3
Zn content in liver1.92.12.11.4