Majin

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000054336 0.12 0.08 9.4e-04 -0 0.04 0.05 0.01 6.8e-01 3.8e-03 7.3e-04 5.6e-02
2 Brain gene expression ENSRNOG00000054336 0.07 0.05 1.7e-03 0.01 0.04 0.03 0.03 1.5e-02 1.3e-04 6.1e-04 5.2e-04
3 Liver gene expression ENSRNOG00000054336 0.03 0.02 3.6e-03 0.01 0.01 0.01 0.01 1.1e-02 1.4e-02 2.0e-02 2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.65.39.02.50.93.0
BMI without tail0.40.92.60.3-0.21.6
Body weight2.08.618.51.52.34.3
Epididymis fat weight1.33.07.20.9-1.0-2.7
Glucose1.11.83.30.9-1.1-1.8
Heart weight2.84.06.4-0.8-2.2-2.5
Left kidney weight0.41.11.81.2-0.1-1.3
Right kidney weight0.61.72.91.71.4-0.5
Tail length0.51.62.5-1.60.61.4
Length with tail1.24.49.0-0.22.03.0
Length without tail1.63.46.30.81.82.5
Liver weight, left0.10.10.30.5-0.1-0.2
Liver weight, right0.10.20.40.2-0.7-0.3
Parametrial fat weight1.22.34.21.2-1.2-2.1
Retroperitoneal fat weight2.89.320.21.4-2.4-4.5
Intraocular pressure0.70.91.30.61.2-1.1
Extensor digitorum longus weight3.915.634.31.03.45.9
Soleus weight2.26.513.80.1-2.4-3.7
Tibialis anterior weight6.723.142.71.64.96.5
Tibia length3.08.514.42.83.81.8
Number of licking bursts0.30.40.50.30.70.7
Food consumed during 24 hour testing period0.40.41.10.31.10.2
Times rat made contact with spout0.70.81.8-1.3-0.40.7
Mean time between licks in bursts1.01.42.4-1.6-0.91.0
Mean num. licks in bursts0.80.91.3-1.1-1.0-0.6
Std. dev. time between licks in bursts1.31.52.4-1.5-1.5-0.1
Water consumed over 24 hours0.70.81.5-1.20.31.0
Indifference point 0 sec0.00.00.00.0-0.2-0.1
Indifference point AUC3.03.55.10.72.22.3
Indifference point function ln k7.510.615.1-1.5-3.9-3.8
Indifference point function log k7.510.615.1-1.5-3.9-3.8
Delay discounting total patch changes 0 sec0.10.10.2-0.4-0.4-0.0
Delay discounting total patch changes 12 sec2.93.88.10.21.82.9
Delay discounting total patch changes 18 sec0.70.91.10.71.11.0
Delay discounting total patch changes 24 sec1.72.14.00.11.52.0
Delay discounting total patch changes 6 sec0.40.72.0-0.10.31.4
Delay discounting time to switch 0 sec1.72.53.11.61.41.8
Delay discounting water rate 0 sec2.03.16.7-0.6-1.5-2.6
Delay discounting water rate 12 sec6.810.215.6-2.0-3.3-3.9
Delay discounting water rate 18 sec3.24.25.6-1.3-2.4-2.3
Delay discounting water rate 24 sec2.83.97.2-1.0-1.9-2.7
Delay discounting water rate 6 sec3.75.46.9-1.6-2.6-2.6
Locomotor activity2.54.04.4-2.1-2.1-1.9
Locomotor testing distance4.27.07.8-2.8-2.8-2.3
Locomotor testing rearing3.55.56.1-2.5-2.4-2.1
Light reinforcement 10.30.51.0-1.0-0.4-0.5
Light reinforcement 21.51.93.21.81.1-1.2
Reaction time number correct0.20.20.40.00.60.6
Reaction time mean minus median3.64.66.81.52.62.2
Reaction time mean minus median AUC1.92.43.90.82.01.6
Reaction time num false alarms1.92.64.2-1.8-2.0-0.4
Reaction time num false alarms AUC1.52.23.9-2.0-1.60.2
Reaction time trials correct on left0.20.20.40.00.60.6
Reaction time trials on left0.20.30.50.00.70.7
Reaction time mean0.40.61.10.71.00.4
Reaction time mean AUC0.40.51.00.71.00.4
Median of all reaction times0.10.20.30.50.50.0
Reaction time omissions0.70.91.8-0.40.91.3
Reaction time false alarm rate1.52.13.5-1.7-1.9-0.4
Reaction time premature initiation rate1.31.73.7-1.2-0.21.9
Reaction time premature initiations1.82.65.9-1.30.42.4
Std. dev. reaction times1.31.83.00.91.71.3
Reaction time trials completed0.20.30.50.00.70.7
Reaction time trials AUC0.10.10.2-0.00.40.5
Social response proportion0.91.01.40.61.21.1
Social responses0.20.30.4-0.40.50.6
Social time0.20.30.4-0.50.40.7
Conditioned locomotion0.91.12.40.40.81.5
Cocaine response after cond. corrected1.82.03.3-0.8-1.8-1.5
Cocaine response after cond. not corrected1.31.42.3-0.6-1.5-1.3
Cocaine response before conditioning0.81.01.60.61.31.0
Saline control response2.02.76.9-0.11.12.6
Condit. Reinf. active minus inactive responses0.40.40.90.90.6-0.4
Condit. Reinf. active-inactive response ratio1.92.04.52.10.9-0.9
Condit. Reinf. active responses0.00.10.10.20.40.2
Condit. Reinf. inactive responses0.81.02.3-1.5-0.70.6
Condit. Reinf. lever presses2.83.85.61.62.41.8
Condit. Reinf. lever reinforcers received0.20.30.70.30.80.6
Pavlov. Cond. lever latency1.21.72.4-1.4-1.5-0.8
Pavlov. Cond. magazine entry latency1.92.24.50.41.42.1
Pavlov. Cond. change in total contacts3.24.46.72.02.61.6
Pavlov. Cond. index score2.63.44.71.52.21.8
Pavlov. Cond. latency score2.43.04.01.52.01.6
Pavlov. Cond. lever contacts1.21.72.81.21.70.9
Pavlov. Cond. magazine entry number4.35.38.9-0.9-2.5-3.0
Pavlov. Cond. intertrial magazine entries0.60.71.80.1-0.6-1.4
Pavlov. Cond. lever-magazine prob. diff.2.83.64.71.32.22.0
Pavlov. Cond. response bias2.12.94.41.22.11.7
Conditioned reinforcement - actives0.90.91.70.81.3-0.6
Conditioned reinforcement - inactives2.32.67.80.2-0.2-2.8
Conditioned locomotion3.54.211.4-0.5-0.9-3.4
Intermittent access intake day 1-15 change0.50.50.80.40.9-0.8
Intermittent access intake escalation0.40.40.60.50.6-0.8
Intermittent access intake escalation 20.50.51.10.51.1-0.3
Intermitt. access day 1 inactive lever presses1.21.32.8-0.7-0.7-1.7
Intermitt. access day 15 inactive lever presses1.01.13.20.30.2-1.8
Intermitt. access escalation Index3.63.25.8-0.2-2.4-2.0
Intermittent access day 1 total infusions2.93.37.50.8-1.3-2.7
Intermittent access day 15 total infusions3.53.910.80.8-0.6-3.3
Intermittent access terminal intake (last 3 days)3.03.37.41.60.1-2.7
Intermittent access total infusions2.52.76.61.2-0.4-2.6
Intermittent access day 1 locomotion2.82.94.9-0.4-1.9-2.2
Intermittent access day 15 total locomotion2.12.26.50.0-0.4-2.5
Intermittent access total locomotion2.93.38.41.0-0.7-2.9
Intermittent access standard deviation0.60.61.7-0.20.3-1.3
Cocaine induced anxiety0.60.71.11.01.00.0
Post-drug Anxiety2.32.54.71.12.21.3
Baseline Anxiety1.51.63.3-0.90.81.8
Lifetime Intake2.12.35.70.9-0.8-2.4
Incentive Sensitization - Responses0.50.50.70.80.4-0.7
Incentive Sensitization - Breakpoint0.50.50.80.80.4-0.9
Progressive ratio test 1 active lever presses1.51.54.20.3-0.6-2.0
Progressive ratio test 1 breakpoint1.41.43.70.4-0.5-1.9
Progressive ratio test 1 inactive lever presses1.31.31.8-0.9-1.2-1.3
Progressive ratio test 2 active lever presses2.12.35.81.0-0.1-2.4
Progressive ratio test 2 breakpoint2.52.77.60.6-0.5-2.7
Progressive ratio test 2 inactive lever presses3.74.312.20.3-0.8-3.5
Total sessions with >9 infusions1.21.42.20.0-1.4-1.5
Short access day 1 total inactive lever presses2.52.84.7-0.9-1.7-2.2
Short access day 10 total inactive lever presses4.65.06.0-2.1-2.5-2.1
Short access day 1 total infusions1.92.03.60.5-1.5-1.9
Short access day 10 total infusions1.11.22.00.8-1.0-1.4
Short access total infusions1.01.11.90.3-1.1-1.4
Short access day 1 locomotion1.81.93.2-0.3-1.6-1.8
Short access day 10 total locomotion1.31.42.4-0.1-1.3-1.5
Short access total locomotion1.31.42.1-0.4-1.4-1.4
Compulsive drug intake1.41.42.7-1.1-0.61.7
One hour access (0.3 mA shock)4.85.615.30.4-1.1-3.9
One hour access (shock baseline)4.14.812.81.30.1-3.6
Number of responses in last shaping day1.51.51.8-1.1-1.2-1.3
Context. condit. distance diff. score1.51.82.7-0.4-1.6-1.6
Locomotion velocity, session 10.30.30.6-0.8-0.60.0
Locomotion distance, session 10.20.20.4-0.4-0.50.6
Locomotion velocity, session 21.11.33.20.10.81.8
Locomotion distance, session 20.30.50.8-0.7-0.50.9
Locomotion velocity, session 30.30.40.70.5-0.9-0.5
Locomotion distance, session 30.10.10.1-0.2-0.4-0.3
Stereotopy head waving bouts, day 30.70.81.50.4-1.2-0.8
Stereotopy head waving duration, day 30.50.61.00.4-0.8-1.0
Locomotion velocity, session 70.60.71.00.6-1.0-0.8
Locomotion distance, session 70.60.82.0-0.6-1.4-0.2
Stereotopy head waving bouts, day 70.80.92.11.50.6-0.4
Stereotopy head waving duration, day 71.31.51.81.31.31.0
Locomotion velocity, session 80.40.51.1-0.60.01.1
Locomotion distance, session 80.20.30.40.5-0.6-0.5
Degree of sensitization distance0.20.20.50.3-0.7-0.0
Degree of sensitization stereotypy1.51.62.31.51.40.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.4-0.20.5
Condit. Reinf. active-inactive response ratio0.10.20.4-0.6-0.20.1
Condit. Reinf. active responses0.00.10.10.3-0.00.3
Condit. Reinf. inactive responses0.40.51.31.20.2-0.1
Incentive salience index mean0.10.10.4-0.0-0.10.6
Condit. Reinf. lever presses0.40.60.80.90.70.7
Time in familiar zone, hab. session 10.20.20.20.3-0.4-0.5
Time in novel zone, hab. session 10.90.91.7-1.3-0.9-0.4
Total zone transitions, hab. session 10.30.40.9-0.30.41.0
Total locomotion distance, hab. session 10.20.30.50.2-0.5-0.7
Locomotion velocity, hab. session 10.00.10.10.3-0.2-0.2
Time in familiar zone, hab. session 20.60.61.0-0.9-1.0-0.0
Time in novel zone, hab. session 20.10.10.20.20.40.2
Total zone transitions, hab. session 20.40.51.60.10.11.3
Total locomotion distance, hab. session 20.20.30.80.1-0.9-0.1
Locomotion velocity, hab. session 20.20.30.40.6-0.6-0.3
Novel to familiar place preference ratio2.12.23.91.22.01.2
Novelty place preference1.21.32.40.91.60.7
Time in novel zone, NPP test0.80.91.70.81.30.6
Total zone transitions, NPP test1.01.53.40.21.01.9
Total locomotion distance, NPP test0.10.10.2-0.1-0.50.2
Locomotion velocity, NPP test0.00.00.1-0.1-0.30.3
Pavlov. Cond. lever latency0.20.30.3-0.5-0.5-0.6
Pavlov. Cond. magazine entry latency0.10.20.20.40.30.4
Pavlov. Cond. change in total contacts0.50.60.90.90.90.2
Pavlov. Cond. index score0.20.20.40.40.70.4
Pavlov. Cond. latency score0.10.10.10.30.30.3
Pavlov. Cond. lever contacts0.00.00.0-0.0-0.10.1
Pavlov. Cond. magazine entry number0.50.61.3-0.5-1.1-0.6
Pavlov. Cond. intertrial magazine entries0.20.20.60.20.0-0.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.50.80.6
Pavlov. Cond. response bias0.20.20.40.30.60.3
Bone: apparent density0.40.71.51.20.40.7
Bone surface4.88.49.92.73.22.8
Bone volume2.84.76.52.62.31.5
Bone: connectivity density1.52.33.41.31.31.9
Bone: cortical apparent density0.60.71.7-1.3-0.20.7
Bone: cortical area1.21.82.51.41.61.0
Bone: cortical porosity0.10.10.10.40.00.3
Bone: cortical porosity0.30.30.80.30.30.9
Bone: cortical thickness1.32.14.5-0.91.02.1
Bone: cortical thickness1.01.22.7-1.7-0.50.7
Bone: cortical tissue density0.60.81.9-1.4-0.20.8
Bone: elastic displacement1.92.12.5-1.6-1.6-1.2
Bone: elastic work0.81.01.9-1.4-0.50.9
Bone: endosteal estimation1.22.66.02.4-0.1-1.3
Bone: endosteal perimeter2.24.510.93.30.7-1.5
Bone: final force2.43.95.71.42.02.4
Bone: final moment2.13.55.01.41.92.2
Bone: marrow area1.22.55.52.3-0.3-1.4
Bone: maximum diameter2.24.06.92.62.20.5
Bone: maximum force3.46.06.52.42.42.6
Bone: maximum moment2.95.15.52.22.22.3
Bone: minimum diameter0.91.73.21.8-0.5-1.2
Bone: periosteal estimation1.42.97.12.71.2-0.2
Bone: periosteal perimeter1.42.34.92.21.40.3
Bone: post-yield work4.05.513.33.71.60.7
Bone: stiffness3.14.95.12.12.32.2
Bone: tissue strength0.30.30.50.70.60.2
Bone: trabecular number1.21.83.31.81.30.8
Bone: trabecular spacing1.31.72.7-1.6-1.4-0.5
Bone: trabecular thickness0.30.40.70.5-0.4-0.8
Bone: trabecular tissue density1.52.15.5-0.0-1.0-2.3
Breakpoint value in progressive ratio session2.62.94.40.91.92.1
Distance traveled before self-admin1.21.22.11.01.50.8
Distance traveled after self-admin0.60.60.80.80.90.6
Delta time in closed arm before/after self-admin2.32.24.0-2.0-1.60.1
Delta time in open arm before/after self-admin1.31.32.41.21.50.2
Diff in mean of infusions in LGA sessions0.30.40.6-0.20.80.7
Extinction: sum of active levers before priming2.82.95.80.81.42.4
Active lever presses in extinction session 63.63.56.51.12.61.6
Delta distance traveled before/after self-admin0.20.30.6-0.5-0.7-0.0
Delta ambulatory time before/after self-admin0.50.50.8-0.8-0.90.1
Time in closed arm before self-admin0.70.81.31.11.10.1
Time in closed arm after self-admin0.50.50.9-0.8-1.0-0.0
Time in open arm before self-admin4.34.67.2-2.5-2.7-0.8
Time in open arm after self-admin0.20.30.3-0.6-0.4-0.5
Sum of active levers in priming session hrs 5-65.15.110.01.83.21.4
Time to tail flick, vehicle, before self-admin0.50.50.60.70.80.6
Time to tail flick, vehicle, after self-admin0.40.41.2-0.1-0.21.1
Time to tail flick, test, before self-admin1.21.12.4-0.4-1.5-0.9
Time to tail flick, test, after self-admin0.00.00.00.20.20.1
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.3-0.50.6
Delta time to tail flick, test, before/after SA1.71.53.00.41.71.1
Ambulatory time before self-admin2.02.13.41.61.80.7
Ambulatory time after self-admin0.60.61.51.20.6-0.0
Total heroin consumption3.23.88.10.51.82.8
Area under the delay curve0.50.61.0-0.8-1.0-0.3
Delay disc. indifference point, 0s delay1.41.62.5-1.1-1.6-1.0
Delay disc. indifference point, 16s delay0.50.50.8-0.1-0.7-0.9
Delay disc. indifference point, 2s delay0.10.10.20.5-0.2-0.4
Delay disc. indifference point, 24s delay1.31.32.6-1.6-1.1-0.3
Delay disc. indifference point, 4s delay1.61.72.4-1.5-1.6-0.5
Delay disc. indifference point, 8s delay1.01.01.6-1.2-1.3-0.3
Delay discount exponential model param0.50.50.90.80.90.3
Delay discount hyperbolic model param0.40.40.80.70.90.2
Fecal boli incidents, locomotor time 12.32.54.32.11.80.0
Change in fecal boli incidents, locomotor task1.91.82.7-1.6-1.60.2
Time >=10cm from walls, locomotor time 11.31.32.71.70.7-0.8
Bouts of movement, locomotor time 10.91.01.80.21.11.3
Total resting periods, locomotor time 10.80.91.30.51.11.1
Rest time, locomotor task time 10.60.61.8-0.0-0.3-1.3
Distance moved, locomotor task time 10.00.00.10.1-0.20.3
Vertical activity count, locomotor time 10.80.91.6-0.3-1.0-1.3
Time >=10cm from walls, locomotor time 20.60.61.30.81.10.1
Bouts of movement, locomotor time 20.30.30.9-0.30.20.9
Total resting periods, locomotor time 20.20.20.5-0.20.00.7
Rest time, locomotor task time 21.31.63.6-0.3-1.0-1.9
Distance moved, locomotor task time 20.60.71.4-0.00.81.2
Vertical activity count, locomotor time 20.50.51.2-1.1-0.50.0
Weight adjusted by age1.82.13.10.61.81.6
Seeking ratio, delayed vs. immediate footshock0.20.30.8-0.1-0.9-0.0
Locomotion in novel chamber2.12.66.71.00.0-2.6
Locomotion in novel chamber post-restriction1.41.74.20.3-0.8-2.0
Progressive ratio1.31.52.41.01.11.5
Food seeking constrained by brief footshock0.60.71.4-1.2-0.70.5
Seeking ratio, punishment vs. effort2.63.24.0-1.9-2.0-1.4
Run reversals in cocaine runway, females1.31.32.5-1.0-1.60.5
Run reversals in cocaine runway, males0.10.10.2-0.4-0.0-0.5
Latency to leave start box in cocaine runway0.20.20.40.7-0.2-0.2
Latency to leave start box in cocaine runway, F0.10.10.20.4-0.0-0.1
Latency to leave start box in cocaine runway, M0.10.10.20.5-0.00.0
Cd content in liver0.80.81.40.80.6-1.2
Co content in liver3.74.47.2-2.7-2.0-1.3
Cu content in liver0.10.10.3-0.40.10.5
Fe content in liver0.50.61.00.81.00.3
K content in liver0.80.81.60.80.51.3
Mg content in liver0.10.10.20.4-0.40.2
Mn content in liver2.93.34.91.32.21.8
Na content in liver1.51.62.31.11.51.2
Rb content in liver1.21.62.5-0.3-1.6-1.5
Se content in liver1.72.13.31.81.7-0.1
Sr content in liver2.62.43.80.11.81.9
Zn content in liver0.60.61.4-0.00.71.2