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Pavlov. Cond. latency score

Pavlovian Conditioned Approach, Sign/goal-tracking, average magazine minus lever contact latency on days 4 and 5 of testing, normalized to 1/-1 by dividing by 8 seconds

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

3 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 74868378 76264539 1 1 1.3e-08 0.019 0.88 100 RGD1566134
2 7 16845355 16970279 1 1 3.2e-32 NaN NA NA NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 50 0 1 NA
Body weight 5.6 2 1 50 0 1 NA RGD1566134
Epididymis fat weight 87.6 1 1 50 0 1 NA
Glucose 6.6 1 0 0 0 1 NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 37.5 1 1 50 0 1 NA
Right kidney weight 41.9 1 1 50 0 1 NA
Tail length 58.1 1 1 50 0 1 NA
Length with tail 3.2 1 0 0 0 1 NA
Length without tail 48.3 2 1 50 0 1 NA RGD1566134
Liver weight, left 23.6 1 1 50 0 1 NA
Liver weight, right 9.6 1 0 0 0 1 NA
Parametrial fat weight 14.9 1 1 50 0 1 NA
Retroperitoneal fat weight 3.0 1 0 0 0 1 NA
Intraocular pressure 19.0 1 1 50 0 1 NA
Extensor digitorum longus weight 25.8 1 1 50 0 1 NA
Soleus weight 13.7 1 1 50 0 1 NA
Tibialis anterior weight 59.9 1 1 50 0 1 NA
Tibia length 5.3 1 0 0 0 1 NA
Number of licking bursts 155.0 1 1 50 0 1 NA
Food consumed during 24 hour testing period 11.6 2 0 0 0 1 NA RGD1566134
Times rat made contact with spout 75.1 1 1 50 0 1 NA
Mean time between licks in bursts 54.9 1 1 50 0 1 NA
Mean num. licks in bursts 164.2 1 1 50 0 1 NA
Std. dev. time between licks in bursts 177.7 1 1 50 0 1 NA
Water consumed over 24 hours 7.4 2 0 0 0 1 NA RGD1566134
Indifference point 0 sec 18.7 1 1 50 0 1 NA
Indifference point AUC 42.1 1 1 50 0 1 NA
Indifference point function ln k 4.4 1 0 0 0 1 NA
Indifference point function log k 4.4 1 0 0 0 1 NA
Delay discounting total patch changes 0 sec 17.7 1 1 50 0 1 NA
Delay discounting total patch changes 12 sec 102.7 1 1 50 0 1 NA
Delay discounting total patch changes 18 sec 175.3 1 1 50 0 1 NA
Delay discounting total patch changes 24 sec 21.8 2 1 50 0 1 NA RGD1566134
Delay discounting total patch changes 6 sec 67.7 2 1 50 0 1 NA RGD1566134
Delay discounting time to switch 0 sec 4.3 1 0 0 0 1 RGD1566134
Delay discounting water rate 0 sec 8.1 1 0 0 0 1 NA
Delay discounting water rate 12 sec 26.1 1 1 50 0 1 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0 1 NA
Delay discounting water rate 24 sec 62.7 1 1 50 0 1 NA
Delay discounting water rate 6 sec 44.2 1 1 50 0 1 NA
Locomotor testing distance 11.5 1 0 0 0 1 NA
Locomotor testing rearing 16.8 1 1 50 0 1 NA
Light reinforcement 1 37.6 2 1 50 0 1 NA RGD1566134
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 56.4 1 1 50 0 1 NA
Reaction time num false alarms AUC 79.5 1 1 50 0 1 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 41.3 1 1 50 0 1 NA
Reaction time mean AUC 58.0 1 1 50 0 1 NA
Median of all reaction times 51.2 1 1 50 0 1 NA
Reaction time false alarm rate 63.4 1 1 50 0 1 NA
Reaction time premature initiation rate 32.1 1 1 50 0 1 NA
Reaction time premature initiations 34.3 1 1 50 0 1 NA
Std. dev. reaction times 17.4 1 1 50 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social responses 74.3 1 1 50 0 1 NA
Social time 7.8 1 0 0 0 1 NA
Conditioned locomotion 6.1 1 0 0 0 1 RGD1566134
Cocaine response after cond. corrected 78.0 1 1 50 0 1 NA
Cocaine response after cond. not corrected 102.3 1 1 50 0 1 NA
Cocaine response before conditioning 17.4 1 1 50 0 1 NA
Saline control response 26.0 2 1 50 0 1 NA RGD1566134
Condit. Reinf. active minus inactive responses 29.4 1 1 50 0 1 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 50 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 14.3 1 0 0 0 1 RGD1566134
Pavlov. Cond. lever latency 34.0 2 2 100 0 1 NA RGD1566134
Pavlov. Cond. magazine entry latency 74.6 2 1 50 0 1 NA RGD1566134
Pavlov. Cond. change in total contacts 92.1 2 1 50 0 1 NA RGD1566134
Pavlov. Cond. index score 48.9 2 2 100 0 1 NA RGD1566134
Pavlov. Cond. lever contacts 17.8 2 2 100 0 1 NA RGD1566134
Pavlov. Cond. magazine entry number 106.0 2 1 50 0 1 NA RGD1566134
Pavlov. Cond. intertrial magazine entries 63.9 1 1 50 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 43.3 2 1 50 0 1 NA RGD1566134
Pavlov. Cond. response bias 27.3 2 2 100 0 1 NA RGD1566134
Conditioned reinforcement - actives 13.0 1 0 0 0 1 NA
Conditioned reinforcement - inactives 5.3 1 0 0 0 1 RGD1566134
Conditioned locomotion 9.9 1 0 0 0 1 NA
Intermittent access intake day 1-15 change 61.5 1 1 50 0 1 NA
Intermittent access intake escalation 82.5 1 1 50 0 1 NA
Intermittent access intake escalation 2 24.7 1 1 50 0 1 NA
Intermitt. access day 1 inactive lever presses 19.4 1 1 50 0 1 NA
Intermitt. access escalation Index 9.2 1 0 0 0 1 NA
Intermittent access day 1 total infusions 33.2 2 2 100 0 1 NA RGD1566134
Intermittent access total infusions 5.4 1 0 0 0 1 RGD1566134
Intermittent access day 1 locomotion 18.4 1 1 50 0 1 NA
Intermittent access total locomotion 5.3 1 0 0 0 1 RGD1566134
Post-drug Anxiety 13.7 1 0 0 0 1 NA
Baseline Anxiety 17.3 1 0 0 0 1 RGD1566134
Lifetime Intake 24.7 1 1 50 0 1 RGD1566134
Progressive ratio test 1 active lever presses 10.6 2 0 0 0 1 NA RGD1566134
Progressive ratio test 1 breakpoint 10.0 2 0 0 0 1 NA RGD1566134
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0 1 NA
Progressive ratio test 2 active lever presses 13.3 2 0 0 0 1 NA RGD1566134
Progressive ratio test 2 breakpoint 30.8 2 1 50 0 1 NA RGD1566134
Total sessions with >9 infusions 15.1 1 0 0 0 1 RGD1566134
Short access day 10 total inactive lever presses 9.1 1 0 0 0 1 NA
Short access day 1 total infusions 21.8 1 0 0 0 1 RGD1566134
Short access day 10 total infusions 21.3 2 1 50 0 1 NA RGD1566134
Short access total infusions 56.6 1 1 50 0 1 RGD1566134
Short access day 1 locomotion 11.1 2 0 0 0 1 NA RGD1566134
Short access day 10 total locomotion 5.3 1 0 0 0 1 RGD1566134
Compulsive drug intake 22.6 2 1 50 0 1 NA RGD1566134
One hour access (0.3 mA shock) 7.8 2 0 0 0 1 NA RGD1566134
Context. condit. distance diff. score 102.1 2 1 50 0 1 NA RGD1566134
Locomotion velocity, session 1 117.8 1 1 50 0 1 NA
Locomotion distance, session 1 374.7 1 1 50 0 1 NA
Locomotion velocity, session 2 82.2 1 1 50 0 1 NA
Locomotion distance, session 2 776.0 1 1 50 0 1 NA
Locomotion velocity, session 3 116.1 1 1 50 0 1 NA
Locomotion distance, session 3 82.4 1 1 50 0 1 NA
Stereotopy head waving bouts, day 3 7.7 2 0 0 0 1 NA RGD1566134
Stereotopy head waving duration, day 3 22.3 2 1 50 0 1 NA RGD1566134
Locomotion velocity, session 7 66.3 1 1 50 0 1 NA
Locomotion distance, session 7 21.3 1 1 50 0 1 NA
Stereotopy head waving bouts, day 7 37.2 2 2 100 0 1 NA RGD1566134
Stereotopy head waving duration, day 7 48.2 2 1 50 0 1 NA RGD1566134
Locomotion distance, session 8 102.8 1 1 50 0 1 NA
Degree of sensitization distance 140.6 1 1 50 0 1 NA
Degree of sensitization stereotypy 20.6 2 1 50 0 1 NA RGD1566134
Condit. Reinf. active minus inactive responses 8.5 2 0 0 0 1 NA RGD1566134
Condit. Reinf. active-inactive response ratio 65.1 1 1 50 0 1 NA
Condit. Reinf. active responses 16.6 2 0 0 0 1 NA RGD1566134
Condit. Reinf. inactive responses 12.8 2 0 0 0 1 NA RGD1566134
Incentive salience index mean 13.1 2 0 0 0 1 NA RGD1566134
Condit. Reinf. lever presses 15.5 2 1 50 0 1 NA RGD1566134
Time in familiar zone, hab. session 1 16.4 1 0 0 0 1 NA
Time in novel zone, hab. session 1 12.9 1 0 0 0 1 NA
Total zone transitions, hab. session 1 415.6 1 1 50 0 1 NA
Total locomotion distance, hab. session 1 171.4 1 1 50 0 1 NA
Locomotion velocity, hab. session 1 218.6 1 1 50 0 1 NA
Time in familiar zone, hab. session 2 28.0 1 1 50 0 1 NA
Time in novel zone, hab. session 2 34.1 1 1 50 0 1 NA
Total zone transitions, hab. session 2 256.1 1 1 50 0 1 NA
Total locomotion distance, hab. session 2 90.8 2 1 50 0 1 NA RGD1566134
Locomotion velocity, hab. session 2 95.5 2 1 50 0 1 NA RGD1566134
Total zone transitions, NPP test 228.8 1 1 50 0 1 NA
Total locomotion distance, NPP test 163.4 1 1 50 0 1 NA
Locomotion velocity, NPP test 195.9 1 1 50 0 1 NA
Pavlov. Cond. lever latency 7.6 2 0 0 0 1 NA RGD1566134
Pavlov. Cond. magazine entry latency 56.4 1 1 50 0 1 NA
Pavlov. Cond. change in total contacts 23.1 1 1 50 0 1 NA
Pavlov. Cond. index score 28.9 1 1 50 0 1 NA
Pavlov. Cond. latency score 16.6 1 0 0 0 1 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0 1 NA
Pavlov. Cond. magazine entry number 34.9 1 1 50 0 1 NA
Pavlov. Cond. intertrial magazine entries 6.5 1 0 0 0 1 RGD1566134
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 50 0 1 NA
Pavlov. Cond. response bias 29.4 1 1 50 0 1 NA
Bone: apparent density 16.2 2 1 50 0 1 NA RGD1566134
Bone surface 24.1 2 1 50 0 1 NA RGD1566134
Bone volume 25.4 2 1 50 0 1 NA RGD1566134
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical apparent density 5.4 1 0 0 0 1 RGD1566134
Bone: cortical porosity 109.3 1 1 50 0 1 NA
Bone: cortical porosity 91.2 1 1 50 0 1 NA
Bone: cortical thickness 8.8 1 0 0 0 1 NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: cortical tissue density 5.2 1 0 0 0 1 RGD1566134
Bone: elastic displacement 17.3 1 1 50 0 1 NA
Bone: endosteal estimation 9.9 2 1 50 0 1 NA RGD1566134
Bone: endosteal perimeter 7.0 1 0 0 0 1 RGD1566134
Bone: final force 39.5 1 1 50 0 1 NA
Bone: final moment 31.9 1 1 50 0 1 NA
Bone: marrow area 8.4 2 1 50 0 1 NA RGD1566134
Bone: maximum diameter 7.2 1 0 0 0 1 RGD1566134
Bone: maximum force 42.0 1 1 50 0 1 NA
Bone: maximum moment 29.5 1 1 50 0 1 NA
Bone: minimum diameter 57.3 1 1 50 0 1 NA
Bone: periosteal estimation 7.8 1 0 0 0 1 NA
Bone: periosteal perimeter 6.4 1 0 0 0 1 NA
Bone: post-yield work 82.8 1 1 50 0 1 NA
Bone: stiffness 90.4 1 1 50 0 1 NA
Bone: tissue strength 81.0 1 1 50 0 1 NA
Bone: trabecular number 39.4 1 1 50 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 10.6 2 0 0 0 1 NA RGD1566134
Bone: trabecular tissue density 43.1 1 1 50 0 1 NA
Distance traveled before self-admin 9.8 1 0 0 0 1 NA
Delta time in closed arm before/after self-admin 6.3 1 0 0 0 1 RGD1566134
Delta time in open arm before/after self-admin 23.6 1 1 50 0 1 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0 1 NA
Active lever presses in extinction session 6 8.3 2 0 0 0 1 NA RGD1566134
Delta distance traveled before/after self-admin 8.7 1 0 0 0 1 NA
Time in closed arm before self-admin 50.0 1 1 50 0 1 NA
Time in closed arm after self-admin 25.8 1 1 50 0 1 NA
Time in open arm after self-admin 18.4 1 1 50 0 1 NA
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0 1 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0 1 NA
Ambulatory time before self-admin 5.7 1 0 0 0 1 NA
Delay disc. indifference point, 0s delay 8.2 1 0 0 0 1 RGD1566134
Delay disc. indifference point, 4s delay 23.4 1 0 0 0 1 RGD1566134
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 2 17.9 2 1 50 0 1 NA RGD1566134
Total resting periods, locomotor time 2 5.7 2 0 0 0 1 NA RGD1566134
Rest time, locomotor task time 2 7.0 1 0 0 0 1 NA
Distance moved, locomotor task time 2 7.9 2 0 0 0 1 NA RGD1566134
Weight adjusted by age 13.8 2 1 50 0 1 NA RGD1566134
Seeking ratio, delayed vs. immediate footshock 14.6 2 1 50 0 1 NA RGD1566134
Locomotion in novel chamber 10.2 1 0 0 0 1 NA
Run reversals in cocaine runway, females 11.1 1 0 0 0 1 RGD1566134
Run reversals in cocaine runway, males 25.4 1 1 50 0 1 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0 1 NA
Cd content in liver 140.5 1 1 50 0 1 NA
Co content in liver 83.2 1 1 50 0 1 NA
Fe content in liver 9.6 2 0 0 0 1 NA RGD1566134
K content in liver 62.6 1 1 50 0 1 NA
Mn content in liver 130.2 1 1 50 0 1 NA
Na content in liver 15.7 1 0 0 0 1 RGD1566134
Rb content in liver 14.2 2 1 50 0 1 NA RGD1566134
Se content in liver 47.0 1 1 50 0 1 NA
Zn content in liver 22.3 2 1 50 0 1 NA RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.4
Adipose alternative TSS 0 0.000 1.2
Adipose gene expression 0 0.000 1.2
Adipose isoform ratio 0 0.000 1.3
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.3
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.4
BLA gene expression 0 0.000 1.3
BLA isoform ratio 0 0.000 1.2
BLA intron excision ratio 0 0.000 1.2
BLA mRNA stability 0 0.000 1.3
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 0 0.000 1.3
Brain gene expression 0 0.000 1.3
Brain isoform ratio 0 0.000 1.3
Brain intron excision ratio 0 0.000 1.2
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.2
Eye alternative TSS 0 0.000 1.3
Eye gene expression 0 0.000 1.2
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.3
Eye mRNA stability 0 0.000 1.4
IL alternative polyA 0 0.000 1.3
IL alternative TSS 0 0.000 1.1
IL gene expression 0 0.000 1.3
IL isoform ratio 0 0.000 1.2
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.2
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.3
Liver alternative polyA 0 0.000 1.5
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.3
Liver isoform ratio 0 0.000 1.3
Liver intron excision ratio 1 0.023 1.3
Liver mRNA stability 0 0.000 1.3
NAcc alternative polyA 0 0.000 1.4
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.3
NAcc isoform ratio 0 0.000 1.3
NAcc intron excision ratio 0 0.000 1.2
NAcc mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.1
OFC gene expression 0 0.000 1.3
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.2
OFC mRNA stability 0 0.000 1.3
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.2
PL gene expression 0 0.000 1.3
PL isoform ratio 2 0.090 1.3
PL intron excision ratio 0 0.000 1.2
PL mRNA stability 0 0.000 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.