Hub : Traits

Locomotion velocity, hab. session 2

Average velocity of locomotion during second habituation session for males and females [meters/sec]

Tags: Behavior · Motivation · Novelty · Locomotion

Project: p50_shelly_flagel_2014

3 loci · 5 genes with independent associations · 14 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	140610199	142727457	12	3	4.01e-15	3.07e-15	1.00e+00	Ctsc Grm5
2	chr3	44152620	45549784	1	1	2.12e-07	7.81e-02	6.65e-06	Ly75
3	chr8	108585012	109845634	1	1	9.50e-08	1.37e-01	1.00e+00	Klhdc8b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	18.84	1	1	20	0	1.00e+00	Klhdc8b
BMI without tail	27.06	1	1	20	0	1.00e+00	Klhdc8b
Body weight	20.7	1	1	20	0	1.00e+00	Klhdc8b
Heart weight	17.24	1	0	0	0	1.00e+00	Klhdc8b
Left kidney weight	27.97	1	1	20	0	1.00e+00	Klhdc8b
Right kidney weight	10.32	1	1	20	0	1.00e+00	Klhdc8b
Tail length	8.12	1	0	0	0	1.00e+00	Klhdc8b
Length with tail	6.04	2	1	20	0	1.00e+00	Klhdc8b Ly75
Length without tail	8.83	1	0	0	0	1.00e+00	Ly75
Liver weight, left	13.45	1	0	0	0	1.00e+00	Klhdc8b
Liver weight, right	7.14	1	0	0	1	4.42e-03	Grm5
Retroperitoneal fat weight	7.55	2	1	20	0	1.00e+00	Klhdc8b Ly75
Intraocular pressure	11.89	3	0	0	-0.99	6.21e-21	Ctsc Grm5 LOC102554680
Soleus weight	8.84	1	0	0	0	1.00e+00	Klhdc8b
Tibialis anterior weight	3.75	1	0	0	0	1.00e+00	Ly75
Tibia length	10.96	1	1	20	0	1.00e+00	Klhdc8b
Number of licking bursts	24.53	1	1	20	0	1.00e+00	Klhdc8b
Food consumed during 24 hour testing period	10.38	2	0	0	0	1.00e+00	Klhdc8b Ly75
Mean time between licks in bursts	7.84	3	0	0	1	2.66e-19	Ctsc Grm5 LOC102554680
Mean num. licks in bursts	11.71	1	0	0	0	1.00e+00	Klhdc8b
Water consumed over 24 hours	13.76	2	0	0	0	1.00e+00	Klhdc8b Ly75
Patch foraging indifference point 0 sec	8.18	1	0	0	0	1.00e+00	Klhdc8b
Indifference point function ln k	36.38	1	1	20	0	1.00e+00	Klhdc8b
Indifference point function log k	36.38	1	1	20	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 0 sec	8.89	1	0	0	0	1.00e+00	Klhdc8b
Patch foraging total patch changes 18 sec	13.09	1	0	0	0	1.00e+00	Ly75
Patch foraging time to switch 0 sec	8.51	4	0	0	0.92	2.25e-08	Ctsc Grm5 Klhdc8b LOC102554680
Patch foraging water rate 0 sec	7.05	1	0	0	0	1.00e+00	Grm5
Patch foraging water rate 12 sec	12.17	4	1	20	-0.99	1.86e-18	Ctsc Grm5 Ifngr1 LOC102554680
Patch foraging water rate 18 sec	20.17	3	3	60	-0.99	2.39e-24	Ctsc Grm5 LOC102554680
Patch foraging water rate 24 sec	7.66	2	0	0	-1	2.39e-04	Ctsc Grm5
Patch foraging water rate 6 sec	7.91	2	0	0	-1	1.37e-10	Ctsc Grm5
Locomotor activity	32.32	2	1	20	0	1.00e+00	Klhdc8b Ly75
Locomotor testing distance	35.68	2	1	20	0	1.00e+00	Klhdc8b Ly75
Light reinforcement 1	10.88	3	0	0	1	4.37e-34	Ctsc Grm5 LOC102554680
Light reinforcement 2	20.99	3	3	60	1	3.60e-37	Ctsc Grm5 LOC102554680
Reaction time number correct	18.64	1	1	20	0	1.00e+00	Klhdc8b
Reaction time mean minus median	14.9	1	0	0	0	1.00e+00	Ifngr1
Reaction time mean minus median AUC	15.11	2	0	0	0	1.00e+00	Ifngr1 Ly75
Reaction time num false alarms	12.66	3	0	0	1	4.75e-31	Ctsc Grm5 LOC102554680
Reaction time num false alarms AUC	10.23	3	0	0	1	3.95e-27	Ctsc Grm5 LOC102554680
Reaction time trials correct on left	18.64	1	1	20	0	1.00e+00	Klhdc8b
Reaction time trials on left	19.51	1	1	20	0	1.00e+00	Klhdc8b
Reaction time mean	12.83	2	0	0	0	1.00e+00	Ifngr1 Ly75
Reaction time mean AUC	13.62	3	1	20	0	1.00e+00	Ifngr1 Klhdc8b Ly75
Median of all reaction times	10.19	2	0	0	0	1.00e+00	Ifngr1 Klhdc8b
Reaction time omissions	16.34	2	1	20	0	1.00e+00	Ifngr1 Klhdc8b
Reaction time false alarm rate	13.18	4	1	20	0.99	8.98e-23	Ctsc Grm5 Klhdc8b LOC102554680
Reaction time premature initiation rate	9.14	1	0	0	0	1.00e+00	Ly75
Std. dev. reaction times	16.99	2	1	20	0	1.00e+00	Ifngr1 Ly75
Reaction time trials completed	19.51	1	1	20	0	1.00e+00	Klhdc8b
Reaction time trials AUC	20.65	1	1	20	0	1.00e+00	Klhdc8b
Conditioned locomotion	28.4	1	1	20	0	1.00e+00	Klhdc8b
Cocaine response after cond. not corrected	16.6	1	0	0	0	1.00e+00	Klhdc8b
Cocaine response before conditioning	38.66	1	1	20	0	1.00e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	28.62	1	1	20	0	1.00e+00	Ly75
Condit. Reinf. active-inactive response ratio	11.56	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. active responses	24.88	1	1	20	0	1.00e+00	Ly75
Condit. Reinf. lever presses	8.53	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. lever reinforcers received	19.5	1	1	20	0	1.00e+00	Ly75
Pavlov. Cond. change in total contacts	11.21	1	0	0	0	1.00e+00	Ly75
Pavlov. Cond. magazine entry number	30	1	1	20	0	1.00e+00	Klhdc8b
Conditioned reinforcement - inactives	16.77	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 1 inactive lever presses	13.69	1	0	0	0	1.00e+00	Klhdc8b
Intermitt. access day 15 inactive lever presses	30.78	1	1	20	0	1.00e+00	Klhdc8b
Intermittent access day 15 total infusions	14.21	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access terminal intake (last 3 days)	24.03	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access total infusions	15.45	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access day 1 locomotion	11.5	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access standard deviation	16.8	1	0	0	0	1.00e+00	Klhdc8b
Cocaine induced anxiety	13.65	1	0	0	0	1.00e+00	Klhdc8b
Lifetime Intake	9.49	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 2 inactive lever presses	10.83	1	0	0	0	1.00e+00	Klhdc8b
Total sessions with >9 infusions	16	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 total inactive lever presses	13.04	1	0	0	0	1.00e+00	Klhdc8b
Short access day 10 total inactive lever presses	101.65	1	1	20	0	1.00e+00	Klhdc8b
Short access day 1 total infusions	10.37	2	0	0	1	2.16e-12	Ctsc Grm5
Short access day 10 total infusions	13.17	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 locomotion	11.78	1	0	0	0	1.00e+00	Klhdc8b
One hour access (0.3 mA shock)	13.43	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, session 1	16.27	3	0	0	-1	9.63e-32	Ctsc Grm5 LOC102554680
Locomotion distance, session 1	18.68	2	1	20	0	1.00e+00	Ifngr1 Klhdc8b
Locomotion velocity, session 2	9.23	3	0	0	0	1.00e+00	Ctsc Grm5 Klhdc8b
Locomotion distance, session 2	33.15	1	1	20	0	1.00e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 3	11.1	4	0	0	-0.69	2.77e-02	Ctsc Grm5 Klhdc8b Ly75
Stereotopy head waving bouts, day 3	9.54	3	0	0	1	3.47e-22	Ctsc Grm5 LOC102554680
Stereotopy head waving bouts, day 7	23.7	1	0	0	0	1.00e+00	Ly75
Stereotopy head waving duration, day 7	21.6	1	0	0	0	1.00e+00	Ly75
Locomotion velocity, session 8	8.84	3	0	0	-0.68	2.06e-01	Ctsc Grm5 Klhdc8b
Locomotion distance, session 8	52.78	1	1	20	0	1.00e+00	Klhdc8b
Degree of sensitization distance	17.53	2	0	0	0	1.00e+00	Klhdc8b Ly75
Degree of sensitization stereotypy	38.66	1	1	20	0	1.00e+00	Ly75
Condit. Reinf. active minus inactive responses	26.18	2	1	20	0	1.00e+00	Klhdc8b Ly75
Condit. Reinf. active-inactive response ratio	17.72	2	1	20	0	1.00e+00	Klhdc8b Ly75
Condit. Reinf. active responses	15.93	2	0	0	0	1.00e+00	Klhdc8b Ly75
Incentive salience index mean	20.83	2	1	20	0	1.00e+00	Klhdc8b Ly75
Condit. Reinf. lever presses	10.81	1	0	0	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	20	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 1	13.1	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 1	10.68	6	1	20	-0.4	2.02e-01	Ctsc Grm5 Ifngr1 Klhdc8b LOC102554680 Ly75
Total locomotion distance, hab. session 1	26.62	5	3	60	1	8.06e-38	Ctsc Grm5 Ifngr1 Klhdc8b LOC102554680
Locomotion velocity, hab. session 1	27.58	5	3	60	1	1.07e-37	Ctsc Grm5 Ifngr1 Klhdc8b LOC102554680
Time in familiar zone, hab. session 2	27.1	1	1	20	0	1.00e+00	Klhdc8b
Time in novel zone, hab. session 2	10.13	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 2	34.63	3	1	20	0	1.00e+00	Ifngr1 Klhdc8b Ly75
Total locomotion distance, hab. session 2	33.11	6	5	100	1	8.91e-51	Ctsc Grm5 Ifngr1 Klhdc8b LOC102554680 Ly75
Novel to familiar place preference ratio	22.33	1	0	0	0	1.00e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1.00e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, NPP test	106.24	1	1	20	0	1.00e+00	Klhdc8b
Total locomotion distance, NPP test	39.29	4	4	80	1	4.90e-34	Ctsc Grm5 Klhdc8b LOC102554680
Locomotion velocity, NPP test	38	4	4	80	1	2.83e-33	Ctsc Grm5 Klhdc8b LOC102554680
Pavlov. Cond. change in total contacts	69.48	1	1	20	0	1.00e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. latency score	8.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. magazine entry number	12.23	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. response bias	10.49	1	0	0	0	1.00e+00	Klhdc8b
Bone: apparent density	27.67	1	1	20	0	1.00e+00	Ly75
Bone surface	47.59	1	1	20	0	1.00e+00	Ly75
Bone volume	43.15	1	1	20	0	1.00e+00	Ly75
Bone: connectivity density	21.24	1	1	20	0	1.00e+00	Ly75
Bone: cortical apparent density	18.66	1	0	0	0	1.00e+00	Ly75
Bone: cortical area	12.58	1	0	0	0	1.00e+00	Ly75
Bone: cortical tissue density	17.88	1	0	0	0	1.00e+00	Ly75
Bone: elastic work	15.82	1	0	0	0	1.00e+00	Ly75
Bone: endosteal estimation	9.05	1	0	0	0	1.00e+00	Ly75
Bone: final force	35.73	1	1	20	0	1.00e+00	Ly75
Bone: final moment	48.32	1	1	20	0	1.00e+00	Ly75
Bone: marrow area	9.02	1	0	0	0	1.00e+00	Ly75
Bone: maximum force	14.03	2	1	20	0	1.00e+00	Klhdc8b Ly75
Bone: maximum moment	29.34	1	1	20	0	1.00e+00	Ly75
Bone: minimum diameter	8.69	1	0	0	0	1.00e+00	Ly75
Bone: periosteal estimation	14.82	1	1	20	0	1.00e+00	Ly75
Bone: periosteal perimeter	7.52	1	0	0	0	1.00e+00	Ly75
Bone: post-yield work	18.38	1	0	0	0	1.00e+00	Ifngr1
Bone: stiffness	10.01	3	0	0	0	1.00e+00	Ifngr1 Klhdc8b Ly75
Bone: trabecular number	35.45	1	1	20	0	1.00e+00	Ly75
Bone: trabecular spacing	60.24	1	1	20	0	1.00e+00	Ly75
Bone: trabecular thickness	47.42	1	1	20	0	1.00e+00	Ly75
Delta time in closed arm before/after self-admin	12.84	1	0	0	0	1.00e+00	Klhdc8b
Sum of active levers in priming session hrs 5-6	10.93	2	0	0	0	1.00e+00	Ctsc Grm5
Time to tail flick, vehicle, after self-admin	37.57	1	1	20	0	1.00e+00	Klhdc8b
Delta time to tail flick, vehicle, before/after SA	14.47	1	0	0	0	1.00e+00	Klhdc8b
Total heroin consumption	18.89	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 0s delay	28.7	1	1	20	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 16s delay	13.12	1	0	0	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 4s delay	41.82	1	1	20	0	1.00e+00	Klhdc8b
Fecal boli incidents, locomotor time 1	16.98	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 1	17.42	2	0	0	0	1.00e+00	Klhdc8b Ly75
Distance moved, locomotor task time 1	22.4	2	1	20	0	1.00e+00	Klhdc8b Ly75
Vertical activity count, locomotor time 1	49.01	1	1	20	0	1.00e+00	Klhdc8b
Bouts of movement, locomotor time 2	19.85	1	0	0	0	1.00e+00	Klhdc8b
Total resting periods, locomotor time 2	20.22	1	0	0	0	1.00e+00	Klhdc8b
Rest time, locomotor task time 2	25.34	1	1	20	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 2	42.39	1	1	20	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 2	54.92	1	1	20	0	1.00e+00	Klhdc8b
Weight adjusted by age	25.6	2	1	20	0	1.00e+00	Klhdc8b Ly75
Locomotion in novel chamber	34.01	1	1	20	0	1.00e+00	Ly75
Food seeking constrained by brief footshock	13.25	2	0	0	0	1.00e+00	Klhdc8b Ly75
Run reversals in cocaine runway, females	21.72	1	0	0	0	1.00e+00	Ly75
Latency to leave start box in cocaine runway	12.87	1	0	0	1	1.24e-05	Grm5
Cd content in liver	20.17	1	0	0	0	1.00e+00	Klhdc8b
Cu content in liver	13.19	2	0	0	0	1.00e+00	Ifngr1 Ly75
Fe content in liver	40.39	1	1	20	0	1.00e+00	Klhdc8b
K content in liver	12.57	2	0	0	0	1.00e+00	Klhdc8b Ly75
Mg content in liver	14.79	2	0	0	0	1.00e+00	Klhdc8b Ly75
Mn content in liver	32.26	1	1	20	0	1.00e+00	Ly75
Na content in liver	12.21	3	0	0	-0.72	1.09e-01	Ctsc Klhdc8b Ly75
Rb content in liver	51.88	1	1	20	0	1.00e+00	Klhdc8b
Se content in liver	8.45	1	0	0	0	1.00e+00	Klhdc8b
Sr content in liver	18.28	2	0	0	0	1.00e+00	Klhdc8b Ly75
Zn content in liver	11.38	2	0	0	0	1.00e+00	Klhdc8b Ly75

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.42
Adipose	alternative TSS	0	0	1.36
Adipose	gene expression	0	0	1.34
Adipose	isoform ratio	2	0	1.33
Adipose	intron excision ratio	2	0.1	1.37
Adipose	mRNA stability	0	0	1.35
BLA	alternative polyA	0	0	1.31
BLA	alternative TSS	0	0	1.32
BLA	gene expression	1	0	1.37
BLA	isoform ratio	2	0.1	1.37
BLA	intron excision ratio	0	0	1.28
BLA	mRNA stability	0	0	1.35
Brain	alternative polyA	2	0.1	1.42
Brain	alternative TSS	0	0	1.29
Brain	gene expression	2	0	1.35
Brain	isoform ratio	3	0.1	1.33
Brain	intron excision ratio	0	0	1.28
Brain	mRNA stability	1	0	1.32
Eye	alternative polyA	0	0	1.66
Eye	alternative TSS	0	0	1.34
Eye	gene expression	1	0.1	1.39
Eye	isoform ratio	0	0	1.3
Eye	intron excision ratio	1	0.1	1.6
Eye	mRNA stability	0	0	1.49
IL	alternative polyA	0	0	1.34
IL	alternative TSS	0	0	1.42
IL	gene expression	1	0	1.4
IL	isoform ratio	0	0	1.42
IL	intron excision ratio	0	0	1.34
IL	mRNA stability	0	0	1.31
LHb	alternative polyA	0	0	1.41
LHb	alternative TSS	0	0	1.35
LHb	gene expression	1	0	1.39
LHb	isoform ratio	0	0	1.42
LHb	intron excision ratio	0	0	1.58
LHb	mRNA stability	0	0	1.29
Liver	alternative polyA	0	0	1.36
Liver	alternative TSS	0	0	1.35
Liver	gene expression	2	0	1.31
Liver	isoform ratio	0	0	1.33
Liver	intron excision ratio	0	0	1.29
Liver	mRNA stability	0	0	1.35
NAcc	alternative polyA	0	0	1.38
NAcc	alternative TSS	0	0	1.41
NAcc	gene expression	2	0	1.34
NAcc	isoform ratio	4	0.1	1.36
NAcc	intron excision ratio	0	0	1.32
NAcc	mRNA stability	0	0	1.36
OFC	alternative polyA	0	0	1.39
OFC	alternative TSS	0	0	1.32
OFC	gene expression	1	0	1.42
OFC	isoform ratio	0	0	1.44
OFC	intron excision ratio	0	0	1.34
OFC	mRNA stability	0	0	1.35
PL	alternative polyA	0	0	1.35
PL	alternative TSS	0	0	1.36
PL	gene expression	2	0	1.35
PL	isoform ratio	1	0	1.36
PL	intron excision ratio	0	0	1.3
PL	mRNA stability	0	0	1.32
pVTA	alternative polyA	0	0	1.35
pVTA	alternative TSS	0	0	1.31
pVTA	gene expression	1	0	1.39
pVTA	isoform ratio	0	0	1.34
pVTA	intron excision ratio	0	0	1.3
pVTA	mRNA stability	0	0	1.37
RMTg	alternative polyA	0	0	1.25
RMTg	alternative TSS	0	0	1.32
RMTg	gene expression	0	0	1.28
RMTg	isoform ratio	0	0	1.39
RMTg	intron excision ratio	0	0	1.4
RMTg	mRNA stability	0	0	1.32