Hub : Genes

Gjd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000051691	0.06	0.03	4.6e-08	0.05	0.08	0.06	0.06	1.1e-05	1.4e-07	1.2e-06	1.1e-06
2	Liver	gene expression	ENSRNOG00000051691	0.07	0.05	6.7e-07	0.06	0.04	0.06	0.05	8.6e-07	2.4e-05	2.2e-07	5.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.7	8.9	9.2	3.0	-2.9
BMI without tail	0.1	0.2	0.4	0.6	-0.2
Body weight	4.6	19.5	22.2	4.7	-4.1
Epididymis fat weight	0.2	0.5	0.7	0.5	-0.8
Glucose	0.2	0.3	0.5	-0.1	-0.7
Heart weight	2.9	4.1	5.8	2.4	-1.5
Left kidney weight	0.1	0.3	0.5	0.7	0.3
Right kidney weight	0.1	0.1	0.3	-0.0	-0.5
Tail length	0.0	0.1	0.2	0.3	0.5
Length with tail	1.0	3.7	5.7	2.4	-1.3
Length without tail	2.7	5.9	6.0	2.4	-2.4
Liver weight, left	0.0	0.0	0.1	-0.2	0.0
Liver weight, right	1.0	1.7	3.1	-1.8	0.6
Parametrial fat weight	0.8	1.6	3.1	-1.8	-0.2
Retroperitoneal fat weight	0.0	0.2	0.3	0.3	-0.5
Intraocular pressure	2.2	3.1	5.5	2.3	-0.9
Extensor digitorum longus weight	5.2	20.7	36.2	6.0	-2.3
Soleus weight	0.8	2.3	3.9	0.8	-2.0
Tibialis anterior weight	1.2	4.3	4.8	2.2	-1.9
Tibia length	2.5	7.0	8.5	2.3	-2.9
Number of licking bursts	0.5	0.6	1.1	0.1	-1.1
Food consumed during 24 hour testing period	0.8	0.9	1.1	1.0	-0.9
Times rat made contact with spout	0.1	0.1	0.2	-0.5	-0.1
Mean time between licks in bursts	1.7	2.4	3.8	2.0	-1.0
Mean num. licks in bursts	0.4	0.4	0.6	-0.5	0.8
Std. dev. time between licks in bursts	0.3	0.3	0.3	0.6	-0.5
Water consumed over 24 hours	0.4	0.4	0.5	0.6	-0.7
Indifference point 0 sec	1.9	3.0	3.8	-1.5	1.9
Indifference point AUC	0.0	0.0	0.0	0.2	0.0
Indifference point function ln k	0.2	0.3	0.6	-0.3	0.7
Indifference point function log k	0.2	0.3	0.6	-0.3	0.7
Delay discounting total patch changes 0 sec	1.4	2.3	3.2	-1.2	1.8
Delay discounting total patch changes 12 sec	2.2	2.9	5.1	-2.2	0.8
Delay discounting total patch changes 18 sec	0.3	0.4	0.6	-0.5	0.8
Delay discounting total patch changes 24 sec	1.1	1.4	1.8	-1.3	1.0
Delay discounting total patch changes 6 sec	1.5	2.2	2.5	-1.6	1.4
Delay discounting time to switch 0 sec	0.1	0.1	0.1	-0.3	0.2
Delay discounting water rate 0 sec	0.0	0.1	0.1	-0.3	0.2
Delay discounting water rate 12 sec	0.0	0.0	0.0	-0.1	0.2
Delay discounting water rate 18 sec	0.4	0.5	0.8	-0.9	-0.5
Delay discounting water rate 24 sec	0.2	0.3	0.6	-0.8	0.1
Delay discounting water rate 6 sec	1.0	1.5	2.8	-1.7	0.4
Locomotor activity	0.4	0.7	0.9	-0.7	-0.9
Locomotor testing distance	1.0	1.6	3.0	-1.7	0.4
Locomotor testing rearing	5.8	9.1	11.4	-3.4	2.6
Light reinforcement 1	1.8	3.3	5.5	-2.3	1.0
Light reinforcement 2	0.6	0.7	1.0	-0.7	-1.0
Reaction time number correct	1.7	2.4	3.4	1.2	-1.9
Reaction time mean minus median	0.4	0.5	0.9	1.0	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.2	0.5	-0.1
Reaction time num false alarms	0.2	0.3	0.5	-0.2	-0.7
Reaction time num false alarms AUC	0.3	0.4	0.8	-0.0	-0.9
Reaction time trials correct on left	1.7	2.4	3.4	1.2	-1.9
Reaction time trials on left	1.7	2.4	3.4	1.2	-1.8
Reaction time mean	0.9	1.3	1.8	-0.9	1.3
Reaction time mean AUC	1.0	1.4	1.9	-0.9	1.4
Median of all reaction times	2.0	2.8	2.8	-1.7	1.7
Reaction time omissions	0.5	0.7	1.3	-1.1	0.3
Reaction time false alarm rate	0.1	0.2	0.4	-0.6	0.1
Reaction time premature initiation rate	0.9	1.2	2.3	-1.5	-0.4
Reaction time premature initiations	0.8	1.2	2.1	-0.5	-1.4
Std. dev. reaction times	0.0	0.0	0.0	0.2	0.2
Reaction time trials completed	1.7	2.4	3.4	1.2	-1.8
Reaction time trials AUC	1.4	2.0	2.8	1.2	-1.7
Social response proportion	0.2	0.2	0.3	0.5	-0.3
Social responses	0.2	0.3	0.5	0.0	-0.7
Social time	1.3	1.7	2.7	0.9	-1.6
Conditioned locomotion	0.6	0.7	0.9	-0.7	0.9
Cocaine response after cond. corrected	0.7	0.8	1.1	-0.7	-1.0
Cocaine response after cond. not corrected	0.9	1.0	1.3	-0.8	-1.2
Cocaine response before conditioning	0.0	0.1	0.1	-0.2	0.2
Saline control response	0.9	1.2	2.0	0.6	-1.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.9	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.6	-0.2
Condit. Reinf. active responses	0.5	0.7	1.4	-1.2	-0.2
Condit. Reinf. inactive responses	0.7	0.9	1.8	-1.3	-0.1
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.3
Condit. Reinf. lever reinforcers received	0.7	1.0	1.9	-1.4	0.1
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.5	0.3
Pavlov. Cond. magazine entry latency	0.6	0.6	1.1	0.3	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	-0.8	0.4
Pavlov. Cond. index score	0.2	0.3	0.6	-0.2	-0.8
Pavlov. Cond. latency score	0.2	0.3	0.6	0.0	-0.8
Pavlov. Cond. lever contacts	0.3	0.5	0.5	-0.7	-0.6
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	0.1	0.8
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	0.9	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.7	-0.0	-0.8
Pavlov. Cond. response bias	0.5	0.7	1.0	-1.0	-0.6
Conditioned reinforcement - actives	0.3	0.3	0.4	-0.6	0.4
Conditioned reinforcement - inactives	1.4	1.6	1.7	-1.2	1.3
Conditioned locomotion	0.0	0.1	0.1	-0.3	-0.1
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-1.0	0.3
Intermittent access intake escalation	0.6	0.6	1.2	-1.1	0.2
Intermittent access intake escalation 2	0.1	0.1	0.1	-0.2	-0.3
Intermitt. access day 1 inactive lever presses	2.2	2.3	4.5	-2.1	0.5
Intermitt. access day 15 inactive lever presses	3.6	4.0	6.3	-2.5	1.3
Intermitt. access escalation Index	1.0	0.9	1.1	1.1	-0.8
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.4	-0.1
Intermittent access day 15 total infusions	0.8	0.9	1.7	-1.3	0.4
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.4	-1.2	0.3
Intermittent access total infusions	0.3	0.3	0.6	-0.8	0.1
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.1	0.5
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.0	-0.1
Intermittent access total locomotion	0.5	0.5	0.5	-0.7	0.7
Intermittent access standard deviation	2.5	2.7	3.5	-1.9	1.4
Cocaine induced anxiety	2.6	3.0	4.5	1.3	-2.1
Post-drug Anxiety	0.5	0.5	1.0	0.2	-1.0
Baseline Anxiety	1.6	1.7	2.3	-1.0	1.5
Lifetime Intake	0.5	0.5	1.0	-1.0	0.2
Incentive Sensitization - Responses	0.4	0.4	0.4	-0.6	0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	-0.6	0.5
Progressive ratio test 1 active lever presses	0.7	0.7	0.8	-0.9	0.8
Progressive ratio test 1 breakpoint	0.6	0.6	0.7	-0.8	0.7
Progressive ratio test 1 inactive lever presses	2.4	2.5	3.1	-1.8	1.4
Progressive ratio test 2 active lever presses	1.0	1.1	1.3	-1.1	0.9
Progressive ratio test 2 breakpoint	0.8	0.9	1.0	-1.0	0.9
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.7	-0.8	0.5
Total sessions with >9 infusions	1.3	1.4	1.5	-1.2	1.1
Short access day 1 total inactive lever presses	1.7	1.9	3.2	-1.8	0.8
Short access day 10 total inactive lever presses	0.1	0.1	0.1	-0.1	-0.3
Short access day 1 total infusions	1.8	1.9	2.6	-1.6	1.1
Short access day 10 total infusions	0.2	0.3	0.5	-0.7	-0.1
Short access total infusions	1.0	1.1	1.7	-1.3	0.8
Short access day 1 locomotion	3.3	3.5	4.9	-2.2	1.4
Short access day 10 total locomotion	0.4	0.4	0.4	-0.7	0.6
Short access total locomotion	0.8	0.9	1.3	-0.6	1.1
Compulsive drug intake	1.0	1.0	1.6	0.7	1.3
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.2	0.4
One hour access (shock baseline)	0.3	0.4	0.7	-0.8	-0.3
Number of responses in last shaping day	1.8	1.8	2.3	-1.1	1.5
Context. condit. distance diff. score	0.3	0.4	0.4	0.6	0.6
Locomotion velocity, session 1	0.6	0.6	0.7	0.7	-0.8
Locomotion distance, session 1	3.1	4.0	4.6	1.8	-2.1
Locomotion velocity, session 2	0.0	0.1	0.1	0.1	0.3
Locomotion distance, session 2	0.8	1.2	2.1	0.5	-1.4
Locomotion velocity, session 3	0.4	0.5	0.8	-0.5	0.9
Locomotion distance, session 3	0.1	0.1	0.2	0.4	-0.1
Stereotopy head waving bouts, day 3	2.6	3.1	4.2	-2.1	1.4
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.6	0.2
Locomotion velocity, session 7	1.7	1.8	2.1	1.4	-1.3
Locomotion distance, session 7	0.7	0.9	1.5	1.2	-0.6
Stereotopy head waving bouts, day 7	0.4	0.5	0.9	-1.0	0.1
Stereotopy head waving duration, day 7	0.4	0.5	1.0	-1.0	0.2
Locomotion velocity, session 8	3.8	4.5	7.5	2.7	-1.3
Locomotion distance, session 8	0.9	1.3	1.4	1.2	-1.1
Degree of sensitization distance	1.1	1.1	2.0	1.4	-0.5
Degree of sensitization stereotypy	0.5	0.5	1.0	-1.0	-0.1
Condit. Reinf. active minus inactive responses	1.8	2.0	2.0	-1.4	1.4
Condit. Reinf. active-inactive response ratio	2.9	3.2	3.9	-1.6	2.0
Condit. Reinf. active responses	1.3	1.5	1.7	-1.3	1.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	-0.5
Incentive salience index mean	1.7	2.1	2.6	-1.6	1.2
Condit. Reinf. lever presses	0.3	0.3	0.6	-0.8	0.3
Time in familiar zone, hab. session 1	1.4	1.3	2.6	-0.2	-1.6
Time in novel zone, hab. session 1	2.1	2.1	3.6	-0.7	1.9
Total zone transitions, hab. session 1	0.8	1.1	1.9	1.4	-0.5
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.3	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.1	-0.1
Time in familiar zone, hab. session 2	0.5	0.6	0.9	-0.9	-0.5
Time in novel zone, hab. session 2	0.6	0.6	1.1	-0.2	1.1
Total zone transitions, hab. session 2	1.2	1.5	2.0	1.4	-1.0
Total locomotion distance, hab. session 2	1.0	1.3	1.9	0.8	-1.4
Locomotion velocity, hab. session 2	1.1	1.5	2.0	1.0	-1.4
Novel to familiar place preference ratio	0.4	0.4	0.6	0.4	0.8
Novelty place preference	0.6	0.7	1.3	0.3	1.1
Time in novel zone, NPP test	0.7	0.7	1.4	-0.1	1.2
Total zone transitions, NPP test	1.8	2.6	3.0	1.5	-1.7
Total locomotion distance, NPP test	0.9	1.3	2.1	0.7	-1.5
Locomotion velocity, NPP test	1.3	1.8	2.3	1.2	-1.5
Pavlov. Cond. lever latency	0.8	1.0	1.8	1.3	0.5
Pavlov. Cond. magazine entry latency	4.6	5.9	11.2	-3.3	0.8
Pavlov. Cond. change in total contacts	7.1	7.5	10.7	-3.3	2.1
Pavlov. Cond. index score	2.7	3.5	6.9	-2.6	0.2
Pavlov. Cond. latency score	1.9	2.4	4.8	-2.2	-0.1
Pavlov. Cond. lever contacts	0.6	0.7	0.9	-1.0	-0.7
Pavlov. Cond. magazine entry number	5.7	7.2	13.0	3.6	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	1.0	0.3
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	7.9	-2.8	0.5
Pavlov. Cond. response bias	4.4	5.4	9.8	-3.1	1.0
Bone: apparent density	1.3	2.1	3.8	-2.0	0.6
Bone surface	0.2	0.4	0.8	0.1	-0.9
Bone volume	0.4	0.7	1.3	-0.1	-1.2
Bone: connectivity density	2.2	3.5	5.5	-2.3	1.2
Bone: cortical apparent density	5.4	7.1	8.0	-2.8	2.5
Bone: cortical area	0.0	0.0	0.1	-0.2	-0.2
Bone: cortical porosity	0.3	0.3	0.6	-0.3	-0.8
Bone: cortical porosity	0.6	0.7	1.3	-0.1	-1.1
Bone: cortical thickness	1.0	1.7	2.4	-1.5	1.0
Bone: cortical thickness	5.9	6.9	10.2	-3.2	1.9
Bone: cortical tissue density	5.4	7.1	7.9	-2.8	2.5
Bone: elastic displacement	0.1	0.1	0.1	0.3	0.1
Bone: elastic work	0.2	0.3	0.5	-0.3	-0.7
Bone: endosteal estimation	2.8	6.1	6.6	2.6	-2.4
Bone: endosteal perimeter	1.4	2.9	4.2	2.1	-1.3
Bone: final force	0.6	1.0	1.7	-0.6	-1.3
Bone: final moment	0.7	1.1	2.1	-0.3	-1.5
Bone: marrow area	2.7	5.8	6.3	2.5	-2.3
Bone: maximum diameter	0.1	0.1	0.2	-0.1	-0.4
Bone: maximum force	0.6	1.1	2.0	0.4	-1.4
Bone: maximum moment	0.7	1.2	2.1	0.6	-1.5
Bone: minimum diameter	0.8	1.5	2.0	1.0	-1.4
Bone: periosteal estimation	0.8	1.6	2.3	1.0	-1.5
Bone: periosteal perimeter	1.5	2.4	2.8	1.4	-1.7
Bone: post-yield work	1.3	1.8	2.5	1.6	-1.0
Bone: stiffness	0.3	0.4	0.8	-0.1	-0.9
Bone: tissue strength	1.3	1.3	2.1	1.4	-0.7
Bone: trabecular number	2.6	4.0	7.6	-2.8	0.6
Bone: trabecular spacing	2.5	3.2	3.2	1.8	-1.8
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	0.0
Bone: trabecular tissue density	1.5	2.1	4.2	-0.3	2.0
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.4	-0.3
Distance traveled before self-admin	0.2	0.2	0.5	0.1	-0.7
Distance traveled after self-admin	0.8	0.9	1.2	1.1	-0.8
Delta time in closed arm before/after self-admin	2.5	2.4	3.3	1.8	-1.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.2	-0.3
Extinction: sum of active levers before priming	1.8	1.8	2.3	1.5	-1.1
Active lever presses in extinction session 6	2.1	2.0	2.4	-1.3	-1.6
Delta distance traveled before/after self-admin	0.5	0.6	1.1	1.1	0.0
Delta ambulatory time before/after self-admin	0.6	0.6	1.2	1.1	-0.3
Time in closed arm before self-admin	1.9	2.2	3.0	-1.1	1.7
Time in closed arm after self-admin	0.6	0.7	1.3	0.2	1.1
Time in open arm before self-admin	1.1	1.2	1.4	1.2	-0.9
Time in open arm after self-admin	0.4	0.5	0.6	0.7	-0.6
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	-0.9	-0.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.5	0.6	-0.7
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.3	-0.6
Time to tail flick, test, before self-admin	1.2	1.2	1.6	1.3	-0.9
Time to tail flick, test, after self-admin	0.9	1.0	1.7	0.5	-1.3
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.2	-0.9
Delta time to tail flick, test, before/after SA	0.5	0.4	0.9	-0.9	0.0
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	-0.2
Ambulatory time after self-admin	1.8	2.0	2.3	1.5	-1.3
Total heroin consumption	1.0	1.2	1.3	-1.1	-1.0
Area under the delay curve	0.2	0.3	0.5	-0.7	0.1
Delay disc. indifference point, 0s delay	0.6	0.6	1.2	-1.1	0.2
Delay disc. indifference point, 16s delay	2.1	2.2	2.6	-1.3	1.6
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	-0.7	-1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.2	0.6
Delay disc. indifference point, 4s delay	0.9	0.9	1.7	-1.3	-0.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.2	0.2
Delay discount exponential model param	0.2	0.2	0.3	0.6	0.0
Delay discount hyperbolic model param	0.2	0.2	0.4	0.7	0.1
Fecal boli incidents, locomotor time 1	0.6	0.7	1.1	1.0	-0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.0	-0.2
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.3	-0.4	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	-0.1
Total resting periods, locomotor time 1	0.6	0.7	1.1	1.0	-0.6
Rest time, locomotor task time 1	0.1	0.1	0.1	0.4	-0.1
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.6	0.0
Vertical activity count, locomotor time 1	0.4	0.4	0.7	0.2	-0.8
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.8	-0.9	0.4
Bouts of movement, locomotor time 2	1.7	1.8	2.9	-0.9	1.7
Total resting periods, locomotor time 2	1.8	1.9	3.2	-0.8	1.8
Rest time, locomotor task time 2	0.5	0.6	1.1	1.0	-0.4
Distance moved, locomotor task time 2	0.2	0.2	0.4	0.1	-0.6
Vertical activity count, locomotor time 2	0.4	0.4	0.5	0.5	-0.7
Weight adjusted by age	0.4	0.5	0.9	0.3	-0.9
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	2.5	-1.0	1.6
Locomotion in novel chamber	3.3	4.1	7.7	-2.8	0.6
Locomotion in novel chamber post-restriction	1.0	1.2	2.1	-0.5	-1.4
Progressive ratio	0.1	0.1	0.2	-0.3	-0.4
Food seeking constrained by brief footshock	0.1	0.2	0.2	-0.5	-0.2
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	0.3
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.7	0.3
Run reversals in cocaine runway, males	0.3	0.2	0.5	-0.7	0.0
Latency to leave start box in cocaine runway	0.7	0.8	1.3	1.2	-0.5
Latency to leave start box in cocaine runway, F	1.0	1.0	1.1	1.0	-1.0
Latency to leave start box in cocaine runway, M	0.9	0.8	1.5	-0.4	1.2
Cd content in liver	0.1	0.1	0.3	-0.5	-0.1
Co content in liver	0.2	0.2	0.3	0.6	0.4
Cu content in liver	0.4	0.5	0.8	-0.4	0.9
Fe content in liver	0.9	1.0	1.3	0.9	-1.1
K content in liver	1.8	1.8	3.1	-1.8	0.7
Mg content in liver	3.9	4.0	4.2	-1.9	2.1
Mn content in liver	3.6	4.1	4.7	-2.2	1.9
Na content in liver	0.6	0.6	0.9	-0.6	-0.9
Rb content in liver	1.1	1.3	1.7	-1.3	1.0
Se content in liver	6.0	7.2	10.1	-3.2	2.1
Sr content in liver	0.8	0.7	1.2	-0.5	1.1
Zn content in liver	2.1	2.4	3.6	-1.9	1.0