Hub : Genes

Smyd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr10:60200371:60201453 0.09 0.07 2.5e-08 0.04 0.06 0.06 0.04 4.5e-05 9.3e-07 1.9e-07 5.8e-05
2 Adipose mRNA stability ENSRNOG00000026783 0.03 0.02 6.3e-03 0.03 0.01 0.02 0.03 4.9e-04 2.0e-02 4.5e-03 7.4e-04
3 BLA intron excision ratio chr10:60200371:60201453 0.08 0.06 3.6e-04 0.07 0.05 0.02 0.06 1.7e-04 1.0e-03 2.0e-02 5.6e-04
4 Brain gene expression ENSRNOG00000026783 0.04 0.03 6.2e-03 0.02 0.01 0.02 0.02 4.4e-03 3.1e-02 1.2e-02 4.9e-03
5 Brain intron excision ratio chr10:60200371:60201453 0.11 0.08 9.2e-09 0.08 0.09 0.08 0.09 1.6e-07 6.1e-09 4.4e-08 1.9e-08
6 Brain intron excision ratio chr10:60201227:60201453 0.04 0.03 3.9e-04 0.02 0.04 0.04 0.04 9.8e-03 3.0e-04 9.8e-05 3.1e-04
7 Brain mRNA stability ENSRNOG00000026783 0.07 0.05 2.8e-06 0.06 0.07 0.07 0.07 4.5e-06 8.8e-07 4.3e-07 1.1e-06
8 Eye intron excision ratio chr10:60200371:60201453 0.2 0.14 7.9e-03 0.01 0.09 0.08 0.08 2.0e-01 2.0e-02 2.4e-02 2.7e-02
9 Liver gene expression ENSRNOG00000026783 0.06 0.04 1.2e-05 0.04 0.04 0.04 0.04 1.1e-05 8.2e-05 3.3e-05 4.5e-05
10 Liver intron excision ratio chr10:60200371:60201004 0.02 0.02 9.0e-03 0.01 0.01 0 0.01 1.1e-02 7.4e-03 7.3e-02 1.2e-02
11 Liver intron excision ratio chr10:60200371:60201453 0.03 0.02 3.4e-03 0.01 0.01 0.01 0 6.5e-02 6.8e-02 1.2e-02 1.8e-01
12 Liver mRNA stability ENSRNOG00000026783 0.03 0.02 3.2e-03 0.02 0.01 0.01 0.01 4.6e-03 3.6e-02 4.8e-02 4.5e-02
13 NAcc intron excision ratio chr10:60200371:60201453 0.1 0.07 1.9e-06 0.07 0.08 0.06 0.07 4.7e-06 2.7e-06 3.7e-05 3.5e-06
14 PL intron excision ratio chr10:60200371:60201453 0.06 0.04 3.7e-04 0.04 0.05 0.07 0.05 3.3e-04 1.8e-04 2.2e-06 9.6e-05
15 PL intron excision ratio chr10:60241245:60243122 0.05 0.04 5.1e-03 0.02 0.03 0.03 0.02 2.2e-02 3.3e-03 3.9e-03 8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
BMI with tail0.61.94.4-1.6-1.0-2.11.3-1.91.4-1.7-1.8-0.92.00.3-0.9-1.6-0.1-0.3
BMI without tail0.30.71.7-0.9-0.9-0.4-0.4-0.90.2-1.0-0.9-1.00.8-0.2-0.8-1.0-1.3-0.9
Body weight1.87.710.4-3.2-3.1-1.5-1.0-2.91.9-3.2-3.0-3.02.7-2.6-3.1-3.2-3.0-2.9
Epididymis fat weight3.27.512.0-3.3-2.8-2.70.5-3.32.5-3.5-3.3-2.73.3-1.3-2.8-3.3-1.7-2.1
Glucose2.43.76.32.31.82.3-0.92.5-1.72.42.41.8-2.50.21.82.30.51.1
Heart weight0.20.20.4-0.5-0.6-0.1-0.4-0.40.2-0.4-0.5-0.60.4-0.6-0.5-0.5-0.2-0.6
Left kidney weight1.44.113.11.60.23.4-3.62.3-1.31.71.90.3-2.5-2.70.31.4-2.1-1.1
Right kidney weight1.23.412.11.2-0.13.1-3.51.9-1.11.21.50.0-2.1-2.80.01.0-2.1-1.3
Tail length2.88.425.5-2.3-3.21.1-3.9-1.30.6-2.2-1.8-3.20.9-3.9-3.2-2.3-5.1-4.0
Length with tail1.65.913.7-2.2-2.80.4-2.7-1.50.9-2.2-1.9-2.71.3-3.3-2.9-2.2-3.7-3.2
Length without tail1.32.84.0-2.0-1.9-1.2-0.3-1.81.6-2.0-1.9-1.81.8-1.7-1.9-1.9-1.1-1.6
Liver weight, left1.32.25.2-1.0-1.70.8-2.2-0.50.3-1.0-0.8-1.60.3-2.3-1.6-1.1-2.2-2.2
Liver weight, right1.11.85.6-1.3-1.60.2-1.5-0.80.3-1.1-1.0-1.60.7-1.5-1.5-1.2-2.4-1.8
Parametrial fat weight8.416.525.5-5.1-4.4-3.1-0.5-4.62.6-4.9-4.7-4.44.5-2.8-4.4-4.7-4.0-3.7
Retroperitoneal fat weight0.00.11.0-0.2-0.00.2-0.30.0-0.30.00.00.0-0.1-1.0-0.0-0.0-0.4-0.1
Intraocular pressure1.01.43.40.71.2-0.81.80.4-0.30.70.61.4-0.21.61.50.91.81.8
Extensor digitorum longus weight2.911.430.2-3.8-1.8-5.54.2-4.43.5-3.8-4.0-1.84.71.2-1.7-3.41.70.0
Soleus weight3.911.517.7-4.2-3.9-2.7-0.2-3.83.2-4.0-3.9-3.53.7-3.0-3.5-3.9-2.3-3.0
Tibialis anterior weight5.418.539.9-5.1-2.8-6.33.9-5.74.5-5.2-5.4-3.15.90.3-3.1-4.80.3-1.2
Tibia length0.82.210.0-0.3-0.51.6-2.80.1-0.3-0.5-0.2-1.4-0.4-1.9-1.3-0.6-3.2-2.1
Number of licking bursts0.30.40.60.60.70.7-0.30.8-0.50.80.70.6-0.8-0.50.60.70.40.4
Food consumed during 24 hour testing period0.30.30.9-0.6-1.0-0.50.2-0.60.4-0.7-0.6-0.50.60.2-0.5-0.6-0.2-0.4
Times rat made contact with spout0.70.82.90.5-0.71.6-1.70.9-0.70.60.7-0.1-1.0-0.9-0.10.5-1.1-0.7
Mean time between licks in bursts0.50.82.5-0.8-0.70.3-1.0-0.40.5-0.6-0.5-0.90.3-1.6-0.9-0.7-1.4-1.1
Mean num. licks in bursts0.30.41.5-0.2-1.20.4-0.9-0.1-0.0-0.4-0.3-0.70.0-0.1-0.7-0.4-1.2-0.9
Std. dev. time between licks in bursts0.20.20.6-0.5-0.3-0.80.6-0.60.6-0.5-0.5-0.20.60.0-0.2-0.40.50.1
Water consumed over 24 hours0.60.72.1-0.3-1.20.8-1.40.00.0-0.3-0.1-0.8-0.2-1.3-0.8-0.3-1.3-1.2
Indifference point 0 sec0.10.20.4-0.3-0.1-0.60.6-0.50.4-0.5-0.4-0.20.5-0.0-0.3-0.40.70.0
Indifference point AUC0.60.72.60.71.60.10.70.7-0.40.90.81.1-0.60.61.10.90.61.2
Indifference point function ln k0.60.81.4-0.8-1.2-1.00.5-1.10.8-1.1-1.1-0.91.10.4-1.0-1.00.2-0.5
Indifference point function log k0.60.81.4-0.8-1.2-1.00.5-1.10.8-1.1-1.1-0.91.10.4-1.0-1.00.2-0.5
Delay discounting total patch changes 0 sec0.10.20.6-0.20.0-0.70.8-0.50.4-0.4-0.4-0.10.50.2-0.2-0.30.80.2
Delay discounting total patch changes 12 sec0.30.40.80.50.90.9-0.60.8-0.50.70.80.5-0.9-0.60.50.7-0.40.2
Delay discounting total patch changes 18 sec0.40.61.50.50.81.2-0.90.9-0.70.80.80.3-1.0-1.20.30.7-0.4-0.0
Delay discounting total patch changes 24 sec0.70.81.31.00.90.9-0.21.1-0.91.11.10.9-1.1-0.20.91.10.70.7
Delay discounting total patch changes 6 sec0.40.71.90.81.4-0.10.80.5-0.30.70.61.0-0.50.60.90.81.41.0
Delay discounting time to switch 0 sec0.81.24.60.2-0.41.7-2.10.8-0.40.40.6-0.4-1.0-2.0-0.40.3-1.6-1.1
Delay discounting water rate 0 sec0.50.72.90.10.5-1.11.7-0.30.30.1-0.10.60.41.40.50.11.61.1
Delay discounting water rate 12 sec0.00.00.1-0.1-0.3-0.20.2-0.20.2-0.2-0.2-0.20.20.1-0.3-0.20.2-0.1
Delay discounting water rate 18 sec1.82.45.5-1.5-1.4-2.31.8-2.01.5-1.8-1.8-1.02.10.4-1.1-1.60.9-0.3
Delay discounting water rate 24 sec0.20.31.1-0.30.5-0.81.1-0.30.6-0.1-0.20.10.40.60.2-0.10.60.6
Delay discounting water rate 6 sec0.40.51.20.80.50.10.50.6-0.50.80.70.8-0.51.10.80.71.10.9
Locomotor activity0.10.10.3-0.50.2-0.2-0.0-0.3-0.0-0.2-0.3-0.30.3-0.6-0.5-0.3-0.4-0.2
Locomotor testing distance0.00.00.2-0.3-0.4-0.10.1-0.2-0.2-0.1-0.2-0.10.2-0.4-0.3-0.20.1-0.1
Locomotor testing rearing0.10.21.1-0.50.3-0.91.0-0.40.2-0.3-0.30.10.60.40.1-0.20.20.5
Light reinforcement 10.00.10.2-0.3-0.4-0.10.1-0.1-0.2-0.1-0.1-0.00.2-0.5-0.0-0.10.30.1
Light reinforcement 21.21.64.41.20.02.1-1.71.7-1.21.51.50.7-1.8-1.10.81.3-0.3-0.0
Reaction time number correct0.10.10.2-0.50.2-0.1-0.2-0.30.1-0.3-0.3-0.40.3-0.3-0.4-0.3-0.1-0.3
Reaction time mean minus median0.30.51.50.51.2-0.20.70.3-0.30.50.40.8-0.30.80.80.60.80.9
Reaction time mean minus median AUC0.50.72.6-0.40.5-1.41.6-0.70.4-0.4-0.50.40.81.30.4-0.21.00.9
Reaction time num false alarms1.11.55.30.71.0-1.01.90.2-0.10.60.41.2-0.02.31.20.72.11.6
Reaction time num false alarms AUC1.11.55.30.81.0-0.91.90.2-0.00.60.51.3-0.12.11.20.72.31.6
Reaction time trials correct on left0.10.10.2-0.50.2-0.1-0.2-0.30.1-0.3-0.3-0.40.3-0.3-0.4-0.3-0.1-0.3
Reaction time trials on left0.10.10.2-0.40.3-0.1-0.1-0.30.0-0.3-0.3-0.40.3-0.2-0.4-0.3-0.1-0.3
Reaction time mean0.20.20.90.70.80.2-0.00.4-0.30.40.40.4-0.40.90.50.40.20.3
Reaction time mean AUC0.50.71.71.01.20.30.20.7-0.50.80.80.8-0.71.30.90.80.60.7
Median of all reaction times0.20.30.70.80.60.5-0.40.6-0.40.50.60.3-0.60.80.40.5-0.00.1
Reaction time omissions0.10.10.30.20.50.2-0.20.1-0.50.10.10.0-0.10.60.10.1-0.3-0.0
Reaction time false alarm rate0.81.23.90.70.6-0.91.80.20.10.50.41.2-0.01.91.20.62.01.5
Reaction time premature initiation rate0.30.40.9-0.6-0.9-0.90.9-0.80.5-0.7-0.7-0.30.80.3-0.4-0.60.90.0
Reaction time premature initiations0.40.51.0-0.8-0.7-1.00.8-0.90.4-0.8-0.8-0.40.90.3-0.5-0.70.8-0.0
Std. dev. reaction times0.40.51.60.61.3-0.30.80.3-0.20.50.40.8-0.21.20.80.50.90.9
Reaction time trials completed0.10.10.2-0.40.3-0.1-0.1-0.30.0-0.3-0.3-0.40.3-0.2-0.4-0.3-0.1-0.3
Reaction time trials AUC0.00.10.2-0.40.3-0.1-0.1-0.30.0-0.3-0.3-0.30.3-0.2-0.3-0.3-0.1-0.2
Social response proportion3.33.55.7-1.9-2.2-0.5-1.2-1.80.8-2.1-1.9-2.31.6-1.5-2.4-2.1-2.2-2.3
Social responses2.02.63.8-1.9-1.8-1.0-0.4-1.71.1-1.9-1.8-1.71.7-1.4-1.9-1.8-1.6-1.5
Social time2.63.45.3-2.3-1.7-1.80.3-2.21.8-2.3-2.2-2.02.2-0.6-2.0-2.2-1.4-1.5
Conditioned locomotion0.80.91.71.11.10.60.31.0-0.91.11.01.1-0.91.31.11.10.61.0
Cocaine response after cond. corrected0.20.20.7-0.1-0.40.1-0.7-0.40.0-0.5-0.4-0.60.3-0.2-0.7-0.5-0.5-0.8
Cocaine response after cond. not corrected0.50.61.1-0.6-0.5-0.3-0.6-0.80.4-1.0-0.9-1.00.7-0.4-1.0-0.9-1.0-1.1
Cocaine response before conditioning0.91.12.0-1.4-0.7-1.30.5-1.31.1-1.3-1.3-1.01.4-0.4-0.9-1.2-0.7-0.6
Saline control response0.30.41.3-0.6-0.2-1.11.0-0.80.8-0.7-0.7-0.20.90.3-0.2-0.60.40.1
Condit. Reinf. active minus inactive responses0.20.30.6-0.5-0.3-0.70.4-0.70.3-0.7-0.7-0.40.80.3-0.4-0.60.3-0.1
Condit. Reinf. active-inactive response ratio0.10.20.60.3-0.50.5-0.80.1-0.7-0.1-0.0-0.2-0.10.5-0.2-0.1-0.1-0.4
Condit. Reinf. active responses0.40.61.8-0.90.1-1.31.3-1.00.5-0.8-0.9-0.21.10.4-0.1-0.70.50.4
Condit. Reinf. inactive responses1.31.66.9-1.30.9-2.22.6-1.11.3-0.7-0.90.31.40.40.3-0.51.11.2
Condit. Reinf. lever presses0.60.81.80.61.3-0.01.00.6-0.50.90.81.2-0.50.71.20.91.01.3
Condit. Reinf. lever reinforcers received0.40.51.8-0.80.3-1.31.3-0.90.4-0.6-0.70.01.00.50.0-0.50.60.5
Pavlov. Cond. lever latency1.01.32.2-1.2-1.0-1.20.2-1.40.9-1.5-1.5-1.31.4-0.0-1.3-1.4-0.4-1.0
Pavlov. Cond. magazine entry latency0.50.61.70.70.11.3-1.31.0-0.40.70.80.3-1.1-0.80.30.7-0.7-0.3
Pavlov. Cond. change in total contacts0.50.71.40.80.61.2-0.71.1-0.71.01.10.8-1.1-0.50.71.0-0.30.3
Pavlov. Cond. index score1.11.52.61.31.11.4-0.41.6-0.81.61.61.3-1.6-0.31.31.50.30.9
Pavlov. Cond. latency score1.51.93.11.51.21.4-0.31.7-0.91.81.71.5-1.7-0.11.51.70.51.1
Pavlov. Cond. lever contacts0.50.61.20.70.51.1-0.51.1-0.61.01.00.8-1.1-0.40.81.0-0.10.4
Pavlov. Cond. magazine entry number0.70.92.0-0.8-0.6-1.41.1-1.20.4-1.0-1.1-0.61.30.9-0.6-1.00.7-0.0
Pavlov. Cond. intertrial magazine entries1.11.53.5-1.3-0.5-1.91.3-1.60.7-1.4-1.5-0.81.81.0-0.8-1.30.3-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.32.31.21.01.3-0.41.5-0.71.51.51.3-1.5-0.21.31.40.20.9
Pavlov. Cond. response bias0.70.91.80.90.71.4-0.81.3-0.61.21.20.8-1.3-0.60.81.1-0.40.3
Conditioned reinforcement - actives1.21.23.6-1.2-0.2-1.91.6-1.31.3-1.1-1.2-0.41.50.6-0.5-1.00.80.3
Conditioned reinforcement - inactives0.20.30.9-0.4-0.1-0.91.0-0.60.0-0.4-0.50.00.70.50.1-0.40.40.4
Conditioned locomotion0.20.20.50.30.60.10.30.4-0.10.50.50.5-0.4-0.10.30.50.70.6
Intermittent access intake day 1-15 change1.51.54.10.71.1-0.71.90.40.10.80.71.4-0.31.91.40.92.01.7
Intermittent access intake escalation1.81.83.31.21.30.11.21.1-0.61.41.21.7-1.01.51.71.41.81.8
Intermittent access intake escalation 22.42.33.61.51.70.61.01.4-0.81.71.61.9-1.41.61.91.71.71.8
Intermitt. access day 1 inactive lever presses2.52.75.01.71.81.9-0.72.0-2.22.02.01.6-2.00.11.61.90.31.1
Intermitt. access day 15 inactive lever presses0.91.02.40.81.50.70.21.1-1.01.21.11.0-1.00.51.11.20.71.0
Intermitt. access escalation Index5.14.511.8-2.4-2.00.2-2.3-1.31.0-1.9-1.6-2.41.1-2.5-2.5-1.9-3.4-2.8
Intermittent access day 1 total infusions0.40.40.9-0.7-0.5-1.00.7-0.90.7-0.8-0.8-0.50.90.3-0.4-0.70.1-0.1
Intermittent access day 15 total infusions0.91.03.90.10.5-1.22.0-0.30.50.0-0.10.80.51.60.80.21.71.3
Intermittent access terminal intake (last 3 days)0.91.02.7-0.8-0.4-1.61.6-1.21.1-0.9-1.0-0.31.31.0-0.2-0.80.80.3
Intermittent access total infusions0.50.52.1-0.2-0.1-1.01.4-0.40.7-0.2-0.30.30.51.20.4-0.11.30.7
Intermittent access day 1 locomotion0.10.10.30.2-0.20.6-0.60.4-0.00.40.40.1-0.5-0.20.10.3-0.2-0.1
Intermittent access day 15 total locomotion0.50.60.90.70.60.20.50.7-0.60.90.70.9-0.60.71.00.80.91.0
Intermittent access total locomotion0.10.10.30.2-0.00.00.20.20.20.30.30.4-0.20.50.40.30.40.3
Intermittent access standard deviation3.63.89.11.82.2-0.52.51.0-0.71.51.32.2-0.82.82.41.63.02.6
Cocaine induced anxiety0.70.82.10.80.9-0.41.20.4-0.10.60.50.9-0.21.31.00.71.41.2
Post-drug Anxiety0.20.20.80.2-0.4-0.60.8-0.20.3-0.1-0.10.20.30.50.2-0.00.90.4
Baseline Anxiety0.20.21.0-0.5-0.60.2-0.6-0.2-0.0-0.4-0.3-0.50.2-1.0-0.5-0.3-0.6-0.6
Lifetime Intake0.50.62.3-0.10.2-1.01.5-0.30.4-0.1-0.20.40.41.20.50.01.40.9
Incentive Sensitization - Responses0.20.20.50.50.5-0.40.7-0.10.10.10.00.40.10.70.40.10.50.6
Incentive Sensitization - Breakpoint0.20.20.40.50.5-0.30.60.00.10.10.10.50.00.60.50.20.50.5
Progressive ratio test 1 active lever presses0.30.31.0-0.7-0.8-0.80.6-0.61.0-0.6-0.6-0.30.60.3-0.3-0.50.3-0.1
Progressive ratio test 1 breakpoint0.70.71.4-1.0-0.7-1.10.7-1.01.2-1.0-1.0-0.61.00.2-0.5-0.90.0-0.3
Progressive ratio test 1 inactive lever presses0.60.71.30.91.10.60.10.9-0.90.90.90.9-0.80.40.90.90.60.8
Progressive ratio test 2 active lever presses0.40.41.50.20.0-0.91.2-0.30.7-0.1-0.20.30.40.90.3-0.01.10.6
Progressive ratio test 2 breakpoint0.40.51.80.20.3-0.91.3-0.30.9-0.1-0.10.40.41.10.50.01.20.8
Progressive ratio test 2 inactive lever presses0.50.62.60.50.2-0.31.20.3-0.40.50.40.9-0.21.10.80.51.61.1
Total sessions with >9 infusions0.10.10.4-0.6-0.2-0.50.4-0.40.6-0.4-0.3-0.20.4-0.0-0.1-0.30.3-0.0
Short access day 1 total inactive lever presses0.20.20.4-0.5-0.1-0.40.1-0.60.2-0.6-0.6-0.40.6-0.2-0.4-0.6-0.4-0.4
Short access day 10 total inactive lever presses0.40.41.60.20.60.9-1.10.4-1.00.20.3-0.1-0.4-0.7-0.10.1-1.3-0.5
Short access day 1 total infusions1.11.23.80.81.3-0.31.50.5-0.10.80.71.2-0.41.31.20.92.01.5
Short access day 10 total infusions0.50.52.1-0.20.2-1.21.4-0.60.7-0.4-0.50.10.80.90.2-0.31.00.6
Short access total infusions0.70.82.80.21.0-0.91.7-0.10.40.20.10.80.21.40.80.31.61.2
Short access day 1 locomotion0.50.51.80.41.00.00.70.6-0.10.70.60.7-0.50.70.80.71.30.9
Short access day 10 total locomotion0.50.50.90.60.70.7-0.10.9-0.60.90.90.7-0.90.30.70.90.60.5
Short access total locomotion0.50.51.10.41.10.20.50.6-0.30.80.70.8-0.50.70.80.70.90.9
Compulsive drug intake0.70.73.1-0.6-1.80.3-1.1-0.20.5-0.5-0.4-0.90.1-1.1-1.0-0.5-0.7-1.1
One hour access (0.3 mA shock)0.91.14.0-0.40.0-1.72.0-0.91.3-0.5-0.60.21.01.40.2-0.41.60.9
One hour access (shock baseline)0.70.83.4-0.10.9-1.31.8-0.50.3-0.1-0.30.50.61.50.6-0.01.21.1
Number of responses in last shaping day1.01.01.61.31.30.70.21.1-0.51.21.21.1-1.10.51.21.20.91.0
Context. condit. distance diff. score1.01.22.1-1.2-0.9-1.30.4-1.41.1-1.4-1.4-1.11.4-0.1-1.2-1.4-0.3-0.8
Locomotion velocity, session 13.63.97.0-2.4-2.6-1.6-0.1-2.21.6-2.3-2.3-2.12.2-1.1-2.1-2.3-1.5-1.7
Locomotion distance, session 10.50.61.4-1.0-0.7-1.20.8-1.00.9-0.9-0.9-0.51.00.0-0.5-0.80.1-0.0
Locomotion velocity, session 20.80.92.3-1.2-1.5-1.00.3-1.10.9-1.1-1.1-0.81.1-0.5-0.8-1.0-0.3-0.5
Locomotion distance, session 21.11.53.4-1.4-1.0-1.81.2-1.61.3-1.5-1.5-0.91.70.4-0.9-1.30.3-0.3
Locomotion velocity, session 32.73.16.72.11.12.6-1.62.3-1.72.12.21.4-2.5-0.31.32.0-0.20.5
Locomotion distance, session 30.10.10.40.20.5-0.20.60.10.10.20.20.5-0.10.60.40.30.20.6
Stereotopy head waving bouts, day 30.40.54.5-0.7-0.50.5-0.9-0.00.3-0.2-0.1-0.5-0.0-2.1-0.5-0.2-0.8-0.7
Stereotopy head waving duration, day 30.30.41.60.10.10.6-0.10.7-0.30.70.60.6-0.6-1.30.60.70.70.5
Locomotion velocity, session 70.60.71.8-0.7-0.6-1.31.1-1.00.7-0.8-0.9-0.41.10.9-0.4-0.70.80.1
Locomotion distance, session 71.01.23.2-1.0-0.7-1.81.3-1.41.1-1.3-1.3-0.61.51.0-0.7-1.10.7-0.1
Stereotopy head waving bouts, day 70.91.12.8-1.7-1.1-0.90.3-1.10.9-1.0-1.1-0.81.1-1.6-0.9-1.0-0.5-0.5
Stereotopy head waving duration, day 71.21.53.5-1.9-1.4-1.20.5-1.31.2-1.3-1.3-1.01.4-1.6-1.0-1.2-0.4-0.6
Locomotion velocity, session 80.30.40.9-0.7-0.9-0.90.7-0.70.6-0.6-0.7-0.40.80.2-0.3-0.60.40.0
Locomotion distance, session 82.03.04.7-2.1-1.8-1.80.5-2.11.7-2.2-2.1-1.82.1-0.6-1.8-2.1-0.5-1.3
Degree of sensitization distance1.11.11.8-1.1-1.3-1.00.0-1.30.8-1.3-1.3-1.21.2-0.2-1.1-1.3-0.1-0.9
Degree of sensitization stereotypy1.41.53.1-1.8-1.5-1.00.1-1.41.0-1.4-1.4-1.21.4-1.2-1.2-1.4-0.8-0.9
Condit. Reinf. active minus inactive responses0.20.20.70.1-0.40.7-0.90.3-0.60.10.2-0.1-0.3-0.3-0.20.1-0.7-0.4
Condit. Reinf. active-inactive response ratio1.31.45.20.6-0.42.1-2.31.1-1.10.70.9-0.2-1.3-1.4-0.20.6-1.4-0.9
Condit. Reinf. active responses0.10.20.3-0.5-0.2-0.50.3-0.50.0-0.5-0.5-0.20.60.5-0.3-0.4-0.2-0.0
Condit. Reinf. inactive responses1.92.27.9-0.80.5-2.62.8-1.41.1-0.9-1.10.31.62.20.2-0.71.71.2
Incentive salience index mean0.30.31.1-0.2-0.90.6-1.0-0.0-0.5-0.2-0.1-0.5-0.1-0.3-0.5-0.3-1.0-0.7
Condit. Reinf. lever presses1.01.42.8-1.1-1.7-0.1-1.0-1.00.3-1.3-1.1-1.40.9-0.6-1.4-1.3-1.6-1.5
Time in familiar zone, hab. session 11.11.14.5-0.10.5-1.51.9-0.60.6-0.2-0.40.40.71.60.4-0.12.11.0
Time in novel zone, hab. session 10.90.83.40.1-0.41.5-1.80.6-0.70.30.4-0.3-0.7-1.6-0.40.2-1.3-0.9
Total zone transitions, hab. session 11.11.55.1-1.0-0.1-2.12.3-1.21.3-0.8-1.00.11.41.10.0-0.71.50.9
Total locomotion distance, hab. session 10.40.51.5-0.8-0.1-1.21.1-0.80.9-0.7-0.7-0.20.9-0.1-0.2-0.60.70.2
Locomotion velocity, hab. session 10.40.61.8-0.7-0.0-1.41.3-0.90.9-0.6-0.7-0.10.90.4-0.1-0.50.80.4
Time in familiar zone, hab. session 21.11.13.4-1.3-0.2-1.81.6-1.31.4-1.0-1.1-0.41.40.1-0.3-0.90.50.3
Time in novel zone, hab. session 22.52.57.41.80.52.7-2.32.0-2.01.61.70.7-2.1-0.40.61.4-0.6-0.3
Total zone transitions, hab. session 20.70.91.9-1.3-0.7-1.40.8-1.31.1-1.1-1.2-0.71.3-0.2-0.7-1.1-0.1-0.3
Total locomotion distance, hab. session 20.10.20.4-0.6-0.1-0.40.0-0.50.6-0.5-0.5-0.40.4-0.6-0.4-0.5-0.4-0.3
Locomotion velocity, hab. session 20.10.10.2-0.5-0.1-0.3-0.0-0.30.4-0.4-0.4-0.40.3-0.5-0.3-0.4-0.3-0.3
Novel to familiar place preference ratio0.70.72.91.10.8-0.00.60.5-0.60.60.60.8-0.41.70.80.71.20.8
Novelty place preference0.30.31.70.80.30.00.30.3-0.50.30.30.4-0.31.30.40.30.80.4
Time in novel zone, NPP test0.10.11.20.50.1-0.20.3-0.0-0.20.00.00.10.01.10.10.10.60.2
Total zone transitions, NPP test0.60.92.7-1.3-0.3-1.71.6-1.11.4-0.8-0.9-0.21.2-0.2-0.2-0.70.60.4
Total locomotion distance, NPP test0.20.31.6-0.40.5-0.91.3-0.20.7-0.0-0.10.40.3-0.10.40.10.70.8
Locomotion velocity, NPP test0.40.51.60.20.9-0.51.30.30.20.50.40.9-0.20.30.90.61.11.2
Pavlov. Cond. lever latency0.30.41.60.01.0-0.81.3-0.10.50.10.00.50.20.60.50.21.00.9
Pavlov. Cond. magazine entry latency0.50.71.4-0.6-0.8-0.1-0.8-0.80.2-1.0-0.9-1.00.7-0.1-1.2-1.0-1.2-1.2
Pavlov. Cond. change in total contacts0.40.41.10.60.31.1-0.80.8-0.90.60.70.3-0.80.00.30.6-0.3-0.0
Pavlov. Cond. index score0.70.92.2-0.7-1.30.2-1.2-0.60.1-0.9-0.8-1.10.5-0.7-1.2-0.9-1.5-1.3
Pavlov. Cond. latency score0.91.23.2-0.7-1.40.4-1.5-0.60.0-0.9-0.7-1.20.4-1.1-1.3-0.9-1.8-1.6
Pavlov. Cond. lever contacts0.30.41.3-0.1-1.00.6-1.1-0.0-0.3-0.3-0.2-0.6-0.1-0.5-0.6-0.3-1.0-0.9
Pavlov. Cond. magazine entry number0.10.20.40.30.30.10.40.4-0.10.50.50.5-0.4-0.00.60.50.60.6
Pavlov. Cond. intertrial magazine entries0.50.62.5-0.20.8-0.91.6-0.20.50.20.00.70.30.50.80.31.21.2
Pavlov. Cond. lever-magazine prob. diff.0.50.71.5-0.7-1.10.0-0.9-0.60.1-0.8-0.7-1.00.5-0.5-1.1-0.9-1.2-1.1
Pavlov. Cond. response bias0.30.40.8-0.4-0.6-0.0-0.6-0.50.0-0.7-0.6-0.80.5-0.0-0.8-0.7-0.8-0.9
Bone: apparent density3.04.98.4-2.7-1.9-2.91.5-2.82.5-2.8-2.7-1.82.9-0.1-1.8-2.5-0.9-1.0
Bone surface2.23.88.7-2.3-1.0-2.91.9-2.62.2-2.4-2.4-1.42.70.6-1.3-2.1-0.2-0.5
Bone volume2.44.09.0-2.5-1.1-3.02.0-2.62.3-2.4-2.4-1.42.70.3-1.3-2.2-0.3-0.5
Bone: connectivity density3.86.012.0-2.9-1.8-3.52.0-3.22.6-3.0-3.0-1.93.30.6-1.8-2.7-0.6-0.9
Bone: cortical apparent density0.60.81.91.01.10.20.70.7-0.50.90.81.1-0.60.91.00.91.41.1
Bone: cortical area1.32.03.71.91.11.7-0.71.8-1.41.61.71.2-1.80.91.21.60.90.7
Bone: cortical porosity0.20.30.8-0.7-0.7-0.3-0.0-0.50.5-0.5-0.5-0.40.4-0.5-0.4-0.5-0.9-0.4
Bone: cortical porosity0.10.10.4-0.2-0.50.1-0.2-0.10.2-0.1-0.1-0.20.1-0.2-0.1-0.1-0.7-0.2
Bone: cortical thickness3.05.011.32.81.33.4-2.23.0-2.32.62.81.6-3.1-0.21.62.50.10.5
Bone: cortical thickness0.60.72.20.7-0.21.5-1.50.9-0.70.60.7-0.0-1.0-0.7-0.10.5-0.8-0.6
Bone: cortical tissue density0.50.61.60.81.00.00.70.5-0.40.70.60.9-0.50.90.90.71.31.0
Bone: elastic displacement0.60.71.10.90.70.40.40.8-0.61.00.91.0-0.80.51.00.90.70.9
Bone: elastic work2.53.26.82.11.12.6-1.52.4-1.82.22.31.4-2.5-0.31.42.0-0.10.5
Bone: endosteal estimation0.10.10.5-0.10.6-0.60.7-0.30.2-0.1-0.20.10.30.40.1-0.10.70.4
Bone: endosteal perimeter0.51.03.6-0.30.6-1.61.9-0.80.5-0.5-0.60.31.01.70.2-0.31.50.9
Bone: final force0.40.62.80.40.01.3-1.70.6-0.30.20.4-0.4-0.7-1.1-0.40.2-1.1-0.9
Bone: final moment0.30.52.00.50.11.2-1.40.6-0.30.30.5-0.2-0.7-0.8-0.20.3-0.8-0.7
Bone: marrow area0.10.10.5-0.10.6-0.50.7-0.20.2-0.1-0.20.10.30.40.1-0.10.70.3
Bone: maximum diameter0.51.04.50.90.9-0.41.10.3-0.50.50.40.9-0.22.10.90.61.81.1
Bone: maximum force0.30.62.20.70.11.4-1.50.8-0.50.50.7-0.0-1.0-0.9-0.00.5-0.6-0.6
Bone: maximum moment0.30.51.60.80.21.2-1.20.9-0.50.60.80.2-1.0-0.60.20.6-0.2-0.3
Bone: minimum diameter0.40.72.11.00.31.4-1.21.0-0.80.80.90.2-1.2-0.20.20.7-0.3-0.2
Bone: periosteal estimation0.30.51.01.00.90.8-0.30.8-0.70.80.80.6-0.90.50.60.80.70.4
Bone: periosteal perimeter0.40.61.80.81.00.00.70.5-0.50.60.60.8-0.41.30.70.71.30.9
Bone: post-yield work0.40.50.8-0.7-0.9-0.3-0.4-0.70.6-0.9-0.8-0.80.7-0.6-0.8-0.8-0.5-0.8
Bone: stiffness1.21.92.6-1.6-1.3-0.7-0.7-1.31.3-1.6-1.4-1.61.2-1.5-1.6-1.5-1.5-1.6
Bone: tissue strength1.31.33.11.21.11.7-1.31.4-1.01.31.30.7-1.5-0.80.71.1-0.30.1
Bone: trabecular number2.94.58.8-2.7-1.5-3.01.7-2.82.4-2.6-2.6-1.62.8-0.0-1.6-2.4-0.6-0.8
Bone: trabecular spacing0.50.71.20.80.71.1-0.51.1-1.01.11.00.7-1.1-0.10.71.0-0.00.5
Bone: trabecular thickness0.20.20.5-0.4-0.4-0.70.5-0.60.6-0.6-0.6-0.30.60.2-0.4-0.50.1-0.1
Bone: trabecular tissue density1.82.54.11.91.61.9-0.82.0-1.51.91.91.4-2.0-0.21.41.80.90.9
Breakpoint value in progressive ratio session1.51.72.8-1.4-1.2-0.6-0.8-1.31.2-1.5-1.3-1.41.2-1.4-1.4-1.4-1.7-1.5
Distance traveled before self-admin1.41.52.71.60.31.3-0.51.6-1.01.31.61.3-1.60.41.41.50.90.8
Distance traveled after self-admin0.10.10.6-0.2-0.50.5-0.60.1-0.30.00.1-0.3-0.2-0.7-0.20.0-0.7-0.3
Delta time in closed arm before/after self-admin0.60.62.30.70.90.30.50.7-0.50.90.70.7-0.60.31.00.81.50.9
Delta time in open arm before/after self-admin1.31.32.5-1.2-1.6-0.8-0.4-1.21.0-1.3-1.2-1.11.1-1.1-1.3-1.3-0.7-1.1
Diff in mean of infusions in LGA sessions1.11.23.9-1.2-1.00.0-1.0-0.80.4-1.0-0.9-1.30.7-1.2-1.2-1.1-2.0-1.4
Extinction: sum of active levers before priming1.51.52.9-1.7-1.2-1.40.6-1.60.8-1.5-1.6-1.31.6-0.2-1.3-1.5-0.1-0.6
Active lever presses in extinction session 61.11.01.8-1.3-1.1-1.10.4-1.30.9-1.2-1.2-0.91.3-0.6-1.0-1.2-0.2-0.5
Delta distance traveled before/after self-admin2.02.13.6-1.9-1.2-0.8-0.3-1.60.8-1.5-1.7-1.81.5-1.1-1.7-1.7-1.7-1.4
Delta ambulatory time before/after self-admin1.61.72.9-1.7-1.2-0.8-0.2-1.40.8-1.4-1.5-1.61.4-1.0-1.5-1.5-1.6-1.2
Time in closed arm before self-admin2.52.95.1-1.9-2.3-1.3-0.2-1.91.5-2.2-1.9-1.71.8-1.1-1.7-1.9-1.7-1.6
Time in closed arm after self-admin0.10.10.20.3-0.40.3-0.10.3-0.30.10.20.2-0.30.20.30.20.20.1
Time in open arm before self-admin4.85.18.42.52.52.6-0.82.8-2.42.92.82.0-2.80.72.12.70.81.5
Time in open arm after self-admin0.80.91.61.01.11.1-0.51.2-1.01.31.20.8-1.20.10.71.10.40.6
Sum of active levers in priming session hrs 5-62.42.43.8-1.8-1.9-0.9-0.5-1.70.7-1.9-1.7-1.71.6-0.8-1.7-1.8-1.8-1.6
Time to tail flick, vehicle, before self-admin4.74.78.3-2.7-1.5-2.51.0-2.82.0-2.6-2.8-2.22.9-0.3-2.1-2.7-0.8-1.4
Time to tail flick, vehicle, after self-admin0.50.62.4-0.50.3-1.21.6-0.70.3-0.4-0.50.00.81.00.1-0.31.00.7
Time to tail flick, test, before self-admin0.40.41.0-0.7-0.4-0.90.5-0.81.0-0.7-0.7-0.60.8-0.0-0.6-0.7-0.1-0.2
Time to tail flick, test, after self-admin0.40.41.3-0.6-1.2-0.1-0.5-0.50.3-0.7-0.6-0.80.5-0.0-0.8-0.6-0.9-0.7
Delta time to tail flick, vehicle, before/after SA1.51.52.51.31.10.50.81.2-0.91.41.31.4-1.10.91.41.41.51.6
Delta time to tail flick, test, before/after SA0.00.00.30.0-0.1-0.20.3-0.0-0.20.0-0.00.20.10.50.10.00.20.2
Ambulatory time before self-admin1.41.52.91.60.41.7-1.11.6-1.01.41.51.1-1.7-0.81.01.40.10.3
Ambulatory time after self-admin1.21.33.9-0.8-1.70.6-1.5-0.40.2-0.8-0.6-1.20.2-1.5-1.2-0.8-2.0-1.5
Total heroin consumption3.84.67.1-2.7-2.3-1.7-0.1-2.41.9-2.5-2.5-2.42.4-0.6-2.4-2.5-1.8-1.9
Area under the delay curve1.31.32.41.21.31.6-1.11.4-1.31.31.30.9-1.4-1.10.71.2-0.10.3
Delay disc. indifference point, 0s delay0.20.21.5-0.60.10.2-0.2-0.1-1.1-0.1-0.1-0.10.2-1.2-0.2-0.1-0.3-0.0
Delay disc. indifference point, 16s delay0.70.71.21.10.81.0-0.51.0-0.71.11.00.8-1.0-0.60.70.90.40.5
Delay disc. indifference point, 2s delay0.91.01.60.91.11.2-0.91.2-0.91.11.20.8-1.3-1.20.71.1-0.30.4
Delay disc. indifference point, 24s delay0.20.20.60.70.50.5-0.30.5-0.30.60.50.3-0.6-0.20.30.50.50.2
Delay disc. indifference point, 4s delay0.90.92.40.40.71.4-1.40.9-1.40.70.80.3-1.0-1.50.10.6-1.1-0.2
Delay disc. indifference point, 8s delay0.60.61.30.90.91.1-0.90.9-1.00.80.90.6-1.0-0.70.40.80.00.1
Delay discount exponential model param1.21.22.5-1.1-1.2-1.61.3-1.31.2-1.2-1.2-0.81.41.2-0.6-1.10.4-0.2
Delay discount hyperbolic model param1.21.32.4-1.1-1.3-1.51.2-1.31.3-1.2-1.2-0.81.41.1-0.6-1.10.4-0.2
Fecal boli incidents, locomotor time 10.20.21.1-0.0-0.6-0.4-0.0-0.41.1-0.4-0.3-0.30.3-0.5-0.2-0.4-0.0-0.3
Change in fecal boli incidents, locomotor task0.50.41.70.30.31.1-1.00.5-1.00.40.4-0.1-0.6-0.0-0.10.3-1.3-0.4
Time >=10cm from walls, locomotor time 10.10.11.0-0.20.4-0.40.4-0.2-0.3-0.1-0.10.10.21.00.3-0.1-0.40.2
Bouts of movement, locomotor time 10.10.10.2-0.0-0.1-0.40.4-0.30.4-0.3-0.3-0.20.3-0.1-0.1-0.30.20.0
Total resting periods, locomotor time 10.10.10.30.10.2-0.40.5-0.20.4-0.2-0.2-0.00.30.40.1-0.10.00.2
Rest time, locomotor task time 10.40.52.70.70.8-0.30.70.3-0.00.50.40.7-0.21.60.80.50.20.8
Distance moved, locomotor task time 10.10.10.4-0.30.0-0.30.4-0.20.0-0.2-0.2-0.00.2-0.4-0.1-0.10.60.1
Vertical activity count, locomotor time 10.40.50.9-0.7-0.6-1.00.8-0.80.5-0.7-0.7-0.30.9-0.6-0.5-0.60.8-0.0
Time >=10cm from walls, locomotor time 20.80.81.80.61.11.1-0.91.0-1.40.90.90.6-1.0-0.10.70.9-1.10.2
Bouts of movement, locomotor time 20.10.10.30.50.30.5-0.40.4-0.40.30.30.1-0.4-0.0-0.00.3-0.6-0.1
Total resting periods, locomotor time 20.00.00.20.20.00.1-0.10.0-0.1-0.0-0.0-0.1-0.00.2-0.3-0.0-0.4-0.2
Rest time, locomotor task time 20.20.21.50.30.2-0.60.6-0.30.3-0.2-0.3-0.00.41.20.2-0.2-0.00.1
Distance moved, locomotor task time 20.40.51.10.00.80.20.40.6-1.00.70.60.9-0.5-0.30.80.70.71.0
Vertical activity count, locomotor time 20.30.30.50.20.10.7-0.40.7-0.50.70.70.5-0.7-0.70.30.60.40.3
Weight adjusted by age0.60.61.8-1.3-0.4-1.10.6-1.00.6-1.0-0.9-0.61.0-0.1-0.6-0.8-0.1-0.3
Seeking ratio, delayed vs. immediate footshock1.72.03.01.61.70.90.31.5-0.91.71.61.7-1.50.31.71.61.31.4
Locomotion in novel chamber4.04.99.22.51.80.51.71.9-1.32.42.22.8-1.71.82.82.43.02.9
Locomotion in novel chamber post-restriction0.10.10.60.2-0.1-0.50.8-0.10.40.1-0.10.30.20.20.30.10.70.5
Progressive ratio0.40.51.90.20.6-0.91.4-0.20.20.1-0.00.50.31.10.70.11.20.9
Food seeking constrained by brief footshock0.10.10.30.30.00.3-0.10.4-0.30.50.40.3-0.40.20.40.40.50.3
Seeking ratio, punishment vs. effort0.40.52.00.2-0.41.3-1.40.7-0.60.50.6-0.1-0.8-0.8-0.20.4-0.7-0.5
Run reversals in cocaine runway, females0.80.83.10.71.8-0.10.90.6-0.40.70.71.1-0.50.61.10.81.21.2
Run reversals in cocaine runway, males0.50.52.40.2-0.1-0.71.3-0.00.00.20.10.60.10.90.70.31.61.0
Latency to leave start box in cocaine runway0.10.10.4-0.10.30.5-0.60.3-0.20.20.20.0-0.3-0.2-0.00.2-0.6-0.2
Latency to leave start box in cocaine runway, F0.10.20.7-0.10.00.5-0.80.10.0-0.00.0-0.3-0.2-0.5-0.3-0.1-0.8-0.6
Latency to leave start box in cocaine runway, M0.10.10.5-0.5-0.50.2-0.4-0.1-0.1-0.2-0.1-0.10.1-0.3-0.3-0.2-0.7-0.3
Cd content in liver0.60.61.5-0.60.2-1.20.9-1.10.6-1.0-1.0-0.51.10.9-0.5-0.90.1-0.1
Co content in liver0.10.10.50.30.70.5-0.30.4-0.10.40.40.3-0.5-0.30.20.4-0.30.1
Cu content in liver0.40.51.70.80.21.3-1.30.9-0.60.60.70.2-1.0-0.30.10.6-0.7-0.4
Fe content in liver0.50.62.0-0.5-0.90.4-1.2-0.40.2-0.6-0.5-0.90.3-0.8-1.0-0.7-1.4-1.2
K content in liver1.51.56.7-0.8-0.81.1-1.90.00.1-0.4-0.2-1.1-0.2-2.6-1.0-0.5-2.1-1.5
Mg content in liver0.10.10.30.00.60.00.20.2-0.10.20.20.2-0.2-0.20.30.20.00.3
Mn content in liver0.20.20.5-0.60.1-0.70.6-0.60.5-0.5-0.5-0.30.6-0.1-0.2-0.40.10.0
Na content in liver1.71.84.81.10.42.2-1.71.7-1.31.51.60.6-1.8-1.50.71.3-0.70.0
Rb content in liver0.60.82.5-0.8-0.3-1.61.5-1.00.8-0.7-0.9-0.21.10.7-0.1-0.70.60.4
Se content in liver0.60.81.80.91.21.3-1.01.1-0.80.91.00.4-1.2-0.30.30.8-0.60.0
Sr content in liver0.50.51.0-0.7-0.7-1.00.7-0.90.6-0.9-0.9-0.51.00.4-0.5-0.80.4-0.2
Zn content in liver0.40.42.00.00.4-1.01.1-0.50.3-0.3-0.40.20.61.40.2-0.21.00.5