Hub : Genes

Loxl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000016758 0.02 0.02 5.7e-03 0.01 0.01 0 0.01 1.9e-02 2.1e-02 7.6e-02 3e-02
2 LHb mRNA stability ENSRNOG00000016758 0.16 0.15 6.2e-03 0 -0.01 -0.01 0.08 3.2e-01 6.8e-01 5.5e-01 7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail0.41.21.41.0-1.2
BMI without tail0.81.61.6-1.31.3
Body weight0.41.51.61.2-1.3
Epididymis fat weight2.35.55.8-2.42.3
Glucose0.00.00.1-0.30.1
Heart weight0.10.10.1-0.30.3
Left kidney weight0.20.40.50.7-0.6
Right kidney weight0.20.50.6-0.60.8
Tail length0.92.62.8-1.61.7
Length with tail0.10.20.20.5-0.5
Length without tail3.78.18.62.8-2.9
Liver weight, left2.13.33.61.7-1.9
Liver weight, right0.71.21.31.1-1.1
Parametrial fat weight3.77.37.4-2.72.7
Retroperitoneal fat weight0.30.91.0-1.01.0
Intraocular pressure0.40.60.6-0.80.7
Extensor digitorum longus weight12.550.250.47.1-7.1
Soleus weight0.92.83.01.6-1.7
Tibialis anterior weight8.127.828.15.3-5.3
Tibia length1.44.04.2-2.02.0
Number of licking bursts0.00.00.0-0.0-0.1
Food consumed during 24 hour testing period0.30.40.5-0.70.5
Times rat made contact with spout0.50.60.7-0.70.9
Mean time between licks in bursts2.02.82.8-1.71.6
Mean num. licks in bursts0.30.40.6-0.50.7
Std. dev. time between licks in bursts1.51.81.9-1.31.4
Water consumed over 24 hours1.21.51.51.2-1.2
Indifference point 0 sec2.13.43.6-1.81.9
Indifference point AUC0.60.70.90.7-0.9
Indifference point function ln k0.00.00.0-0.10.2
Indifference point function log k0.00.00.0-0.10.2
Delay discounting total patch changes 0 sec1.82.93.0-1.71.7
Delay discounting total patch changes 12 sec0.70.91.0-1.00.9
Delay discounting total patch changes 18 sec1.82.32.6-1.61.4
Delay discounting total patch changes 24 sec0.00.00.0-0.10.0
Delay discounting total patch changes 6 sec0.30.40.5-0.60.7
Delay discounting time to switch 0 sec0.71.11.2-1.01.1
Delay discounting water rate 0 sec0.30.40.50.6-0.7
Delay discounting water rate 12 sec0.40.70.70.8-0.8
Delay discounting water rate 18 sec2.63.43.61.9-1.8
Delay discounting water rate 24 sec0.00.00.00.1-0.1
Delay discounting water rate 6 sec2.02.93.21.6-1.8
Locomotor activity1.42.12.31.5-1.4
Locomotor testing distance0.00.00.0-0.00.1
Locomotor testing rearing0.30.40.5-0.60.7
Light reinforcement 13.56.46.9-2.42.6
Light reinforcement 21.31.72.0-1.21.4
Reaction time number correct0.50.81.00.8-1.0
Reaction time mean minus median0.20.30.30.5-0.5
Reaction time mean minus median AUC0.20.20.20.4-0.5
Reaction time num false alarms0.00.00.0-0.0-0.1
Reaction time num false alarms AUC0.00.00.0-0.20.1
Reaction time trials correct on left0.50.81.00.8-1.0
Reaction time trials on left0.40.60.70.6-0.9
Reaction time mean0.30.40.40.6-0.6
Reaction time mean AUC0.50.60.60.7-0.8
Median of all reaction times0.10.10.10.3-0.4
Reaction time omissions2.12.82.9-1.61.7
Reaction time false alarm rate0.20.30.3-0.50.6
Reaction time premature initiation rate1.52.02.31.5-1.3
Reaction time premature initiations2.23.13.31.8-1.7
Std. dev. reaction times0.30.30.40.6-0.6
Reaction time trials completed0.40.60.70.6-0.9
Reaction time trials AUC0.40.50.70.6-0.8
Social response proportion0.00.10.10.2-0.3
Social responses1.01.31.4-1.21.1
Social time0.40.50.5-0.60.7
Conditioned locomotion0.00.10.1-0.30.1
Cocaine response after cond. corrected0.20.20.30.5-0.5
Cocaine response after cond. not corrected0.10.10.10.4-0.4
Cocaine response before conditioning0.10.20.2-0.30.5
Saline control response0.20.20.2-0.40.5
Condit. Reinf. active minus inactive responses0.30.40.4-0.70.6
Condit. Reinf. active-inactive response ratio0.10.10.10.4-0.3
Condit. Reinf. active responses0.91.21.4-1.21.0
Condit. Reinf. inactive responses2.22.83.1-1.81.6
Condit. Reinf. lever presses0.10.10.1-0.30.3
Condit. Reinf. lever reinforcers received0.60.80.9-1.00.8
Pavlov. Cond. lever latency0.30.50.5-0.70.7
Pavlov. Cond. magazine entry latency0.00.10.1-0.20.2
Pavlov. Cond. change in total contacts1.62.32.31.5-1.5
Pavlov. Cond. index score0.50.70.70.8-0.8
Pavlov. Cond. latency score0.30.40.40.7-0.7
Pavlov. Cond. lever contacts0.40.50.50.7-0.7
Pavlov. Cond. magazine entry number0.00.00.10.2-0.2
Pavlov. Cond. intertrial magazine entries6.48.28.5-2.92.8
Pavlov. Cond. lever-magazine prob. diff.0.60.80.80.9-0.9
Pavlov. Cond. response bias0.40.60.60.8-0.8
Conditioned reinforcement - actives2.72.72.7-1.61.6
Conditioned reinforcement - inactives3.03.43.8-1.71.9
Conditioned locomotion1.21.41.5-1.21.2
Intermittent access intake day 1-15 change2.42.42.5-1.61.5
Intermittent access intake escalation1.71.61.7-1.31.2
Intermittent access intake escalation 20.50.50.5-0.70.7
Intermitt. access day 1 inactive lever presses0.10.10.1-0.30.3
Intermitt. access day 15 inactive lever presses0.00.00.10.10.2
Intermitt. access escalation Index0.60.50.60.8-0.7
Intermittent access day 1 total infusions0.00.00.1-0.10.3
Intermittent access day 15 total infusions1.11.31.4-1.11.2
Intermittent access terminal intake (last 3 days)0.30.30.4-0.50.6
Intermittent access total infusions0.50.60.7-0.70.8
Intermittent access day 1 locomotion0.40.40.5-0.50.7
Intermittent access day 15 total locomotion1.61.82.0-1.41.2
Intermittent access total locomotion0.60.70.7-0.80.8
Intermittent access standard deviation1.41.51.5-1.21.2
Cocaine induced anxiety0.10.10.10.4-0.4
Post-drug Anxiety0.50.50.5-0.70.7
Baseline Anxiety0.80.80.8-0.90.9
Lifetime Intake0.50.50.7-0.60.8
Incentive Sensitization - Responses1.11.11.2-1.11.0
Incentive Sensitization - Breakpoint1.51.51.6-1.31.1
Progressive ratio test 1 active lever presses0.20.20.30.5-0.4
Progressive ratio test 1 breakpoint0.10.10.10.4-0.2
Progressive ratio test 1 inactive lever presses1.51.61.9-1.11.4
Progressive ratio test 2 active lever presses0.20.20.2-0.50.4
Progressive ratio test 2 breakpoint0.30.30.3-0.50.5
Progressive ratio test 2 inactive lever presses0.40.40.5-0.60.7
Total sessions with >9 infusions0.00.00.0-0.10.2
Short access day 1 total inactive lever presses0.50.60.7-0.70.8
Short access day 10 total inactive lever presses0.30.30.5-0.50.7
Short access day 1 total infusions0.10.10.20.4-0.2
Short access day 10 total infusions0.00.00.0-0.00.2
Short access total infusions0.20.20.3-0.30.6
Short access day 1 locomotion0.10.20.20.5-0.3
Short access day 10 total locomotion0.60.70.7-0.80.8
Short access total locomotion0.80.81.0-0.81.0
Compulsive drug intake0.00.00.0-0.1-0.2
One hour access (0.3 mA shock)0.30.40.4-0.70.6
One hour access (shock baseline)0.00.00.00.10.1
Number of responses in last shaping day0.00.00.00.1-0.0
Context. condit. distance diff. score0.70.91.0-0.91.0
Locomotion velocity, session 10.20.20.20.5-0.4
Locomotion distance, session 10.00.00.00.00.0
Locomotion velocity, session 20.00.10.1-0.20.2
Locomotion distance, session 20.00.10.1-0.30.2
Locomotion velocity, session 30.50.60.60.7-0.8
Locomotion distance, session 30.00.00.1-0.30.1
Stereotopy head waving bouts, day 30.91.11.31.1-1.0
Stereotopy head waving duration, day 33.13.74.12.0-1.8
Locomotion velocity, session 74.54.95.0-2.22.2
Locomotion distance, session 73.95.05.4-2.32.1
Stereotopy head waving bouts, day 71.82.12.31.5-1.4
Stereotopy head waving duration, day 72.53.13.41.8-1.7
Locomotion velocity, session 80.00.00.0-0.10.1
Locomotion distance, session 80.60.90.9-0.90.9
Degree of sensitization distance5.05.05.1-2.22.2
Degree of sensitization stereotypy1.11.21.41.2-1.1
Condit. Reinf. active minus inactive responses0.70.80.90.9-0.8
Condit. Reinf. active-inactive response ratio2.72.92.91.7-1.7
Condit. Reinf. active responses0.00.00.10.2-0.1
Condit. Reinf. inactive responses2.93.43.6-1.81.9
Incentive salience index mean1.01.21.21.1-1.0
Condit. Reinf. lever presses0.30.40.40.6-0.6
Time in familiar zone, hab. session 10.00.00.00.1-0.1
Time in novel zone, hab. session 11.51.51.51.2-1.2
Total zone transitions, hab. session 10.30.40.40.6-0.6
Total locomotion distance, hab. session 10.00.00.00.1-0.0
Locomotion velocity, hab. session 10.10.10.1-0.30.3
Time in familiar zone, hab. session 22.12.22.41.6-1.4
Time in novel zone, hab. session 20.80.80.9-1.00.8
Total zone transitions, hab. session 21.51.92.01.4-1.4
Total locomotion distance, hab. session 20.30.40.50.7-0.6
Locomotion velocity, hab. session 20.60.90.91.0-0.9
Novel to familiar place preference ratio1.61.71.9-1.41.2
Novelty place preference1.31.31.5-1.21.1
Time in novel zone, NPP test0.60.60.8-0.90.7
Total zone transitions, NPP test0.10.10.2-0.30.5
Total locomotion distance, NPP test2.43.33.5-1.81.9
Locomotion velocity, NPP test2.33.33.5-1.81.9
Pavlov. Cond. lever latency0.00.00.00.2-0.0
Pavlov. Cond. magazine entry latency0.10.10.1-0.30.2
Pavlov. Cond. change in total contacts0.80.91.00.8-1.0
Pavlov. Cond. index score0.00.00.10.1-0.2
Pavlov. Cond. latency score0.00.00.0-0.0-0.1
Pavlov. Cond. lever contacts0.00.00.1-0.30.1
Pavlov. Cond. magazine entry number0.40.50.5-0.60.7
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.3-0.4
Pavlov. Cond. response bias0.10.10.10.2-0.4
Bone: apparent density1.82.93.1-1.71.8
Bone surface0.71.21.2-1.11.1
Bone volume0.91.51.5-1.21.2
Bone: connectivity density3.25.05.2-2.22.3
Bone: cortical apparent density0.00.00.0-0.20.1
Bone: cortical area0.00.00.0-0.20.1
Bone: cortical porosity1.41.51.71.3-1.2
Bone: cortical porosity0.50.60.60.8-0.7
Bone: cortical thickness0.00.00.1-0.30.2
Bone: cortical thickness0.00.00.1-0.20.2
Bone: cortical tissue density0.00.00.0-0.20.1
Bone: elastic displacement0.40.50.5-0.70.7
Bone: elastic work0.20.20.3-0.50.5
Bone: endosteal estimation0.10.20.20.5-0.4
Bone: endosteal perimeter0.00.10.10.3-0.3
Bone: final force0.10.20.20.4-0.5
Bone: final moment0.10.10.10.3-0.4
Bone: marrow area0.00.10.10.3-0.2
Bone: maximum diameter0.20.40.40.6-0.7
Bone: maximum force0.20.40.40.6-0.6
Bone: maximum moment0.10.20.20.4-0.4
Bone: minimum diameter0.10.10.10.4-0.3
Bone: periosteal estimation0.00.00.00.1-0.1
Bone: periosteal perimeter0.00.00.0-0.00.0
Bone: post-yield work0.20.30.4-0.50.6
Bone: stiffness0.50.80.80.9-0.9
Bone: tissue strength0.10.10.2-0.40.2
Bone: trabecular number2.94.64.8-2.12.2
Bone: trabecular spacing2.43.13.31.7-1.8
Bone: trabecular thickness1.31.61.7-1.21.3
Bone: trabecular tissue density1.62.22.41.6-1.4
Breakpoint value in progressive ratio session0.00.00.10.2-0.1
Distance traveled before self-admin0.91.01.11.1-0.9
Distance traveled after self-admin2.12.32.31.5-1.5
Delta time in closed arm before/after self-admin2.22.12.2-1.51.4
Delta time in open arm before/after self-admin0.00.00.0-0.10.2
Diff in mean of infusions in LGA sessions2.52.83.31.8-1.5
Extinction: sum of active levers before priming2.62.62.9-1.71.5
Active lever presses in extinction session 60.40.40.4-0.70.6
Delta distance traveled before/after self-admin2.42.62.81.5-1.7
Delta ambulatory time before/after self-admin2.32.52.81.5-1.7
Time in closed arm before self-admin2.02.32.31.5-1.5
Time in closed arm after self-admin0.70.70.70.8-0.8
Time in open arm before self-admin0.10.10.10.3-0.3
Time in open arm after self-admin0.10.10.1-0.40.2
Sum of active levers in priming session hrs 5-60.10.10.1-0.30.3
Time to tail flick, vehicle, before self-admin1.01.01.1-0.91.1
Time to tail flick, vehicle, after self-admin2.02.12.31.5-1.4
Time to tail flick, test, before self-admin1.11.01.2-1.01.1
Time to tail flick, test, after self-admin3.53.53.6-1.91.9
Delta time to tail flick, vehicle, before/after SA0.50.50.50.6-0.7
Delta time to tail flick, test, before/after SA0.20.20.3-0.50.4
Ambulatory time before self-admin0.60.70.70.8-0.9
Ambulatory time after self-admin3.74.14.22.0-2.1
Total heroin consumption0.20.30.40.7-0.3
Area under the delay curve0.10.10.10.3-0.3
Delay disc. indifference point, 0s delay0.30.30.3-0.60.5
Delay disc. indifference point, 16s delay0.20.20.2-0.40.4
Delay disc. indifference point, 2s delay1.61.71.81.3-1.3
Delay disc. indifference point, 24s delay0.20.20.30.5-0.5
Delay disc. indifference point, 4s delay1.81.92.01.4-1.4
Delay disc. indifference point, 8s delay0.00.00.0-0.00.1
Delay discount exponential model param0.30.30.4-0.60.6
Delay discount hyperbolic model param0.70.70.8-0.90.8
Fecal boli incidents, locomotor time 10.90.91.00.9-1.0
Change in fecal boli incidents, locomotor task0.10.10.20.4-0.2
Time >=10cm from walls, locomotor time 10.60.60.7-0.70.8
Bouts of movement, locomotor time 14.95.45.82.4-2.3
Total resting periods, locomotor time 14.95.55.72.4-2.3
Rest time, locomotor task time 13.33.63.82.0-1.9
Distance moved, locomotor task time 13.13.43.7-1.91.8
Vertical activity count, locomotor time 11.11.21.2-1.11.1
Time >=10cm from walls, locomotor time 20.40.40.40.6-0.6
Bouts of movement, locomotor time 23.43.74.02.0-1.8
Total resting periods, locomotor time 23.94.24.62.1-2.0
Rest time, locomotor task time 21.01.11.21.1-1.0
Distance moved, locomotor task time 22.83.33.7-1.91.7
Vertical activity count, locomotor time 20.30.30.4-0.60.5
Weight adjusted by age1.82.12.11.4-1.4
Seeking ratio, delayed vs. immediate footshock1.41.61.8-1.31.2
Locomotion in novel chamber0.10.20.2-0.50.4
Locomotion in novel chamber post-restriction0.60.70.70.8-0.8
Progressive ratio0.10.10.1-0.30.4
Food seeking constrained by brief footshock1.31.61.61.2-1.3
Seeking ratio, punishment vs. effort0.81.01.11.0-1.1
Run reversals in cocaine runway, females3.73.73.9-1.82.0
Run reversals in cocaine runway, males2.52.42.41.5-1.5
Latency to leave start box in cocaine runway0.40.40.40.6-0.6
Latency to leave start box in cocaine runway, F1.11.21.31.1-1.1
Latency to leave start box in cocaine runway, M1.31.21.2-1.11.1
Cd content in liver0.20.20.3-0.40.6
Co content in liver4.04.74.72.2-2.2
Cu content in liver0.60.80.90.9-0.8
Fe content in liver2.22.62.7-1.61.6
K content in liver0.50.50.6-0.70.8
Mg content in liver1.21.21.3-1.11.1
Mn content in liver2.12.42.4-1.61.5
Na content in liver0.70.70.80.9-0.8
Rb content in liver0.30.40.4-0.60.6
Se content in liver0.91.11.1-1.01.1
Sr content in liver0.40.40.4-0.60.6
Zn content in liver1.11.21.31.1-1.0