Patch foraging time to switch 0 sec

Delay discounting using a sequential patch depletion procedure, time it took the rat to switch water feeders with an experimenter-imposed delay of 0 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

3 loci · 5 genes with independent associations · 11 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr6 68065049 70257655 9 3 4.51e-08 1.07e-06 1e+00 Coch G2e3
2 chr6 70976798 72372377 1 1 1.04e-07 2.76e-07 1e+00 Egln3
3 chr9 75969545 77365260 1 1 6.55e-13 2.23e-01 1e+00 Zfand2b

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 8.42 1 1 20 0 1.00e+00 Zfand2b
BMI without tail 53.65 1 1 20 0 1.00e+00 Zfand2b
Epididymis fat weight 111.28 1 1 20 0 1.00e+00 Zfand2b
Heart weight 71.7 1 1 20 0 1.00e+00 Zfand2b
Left kidney weight 27.22 1 1 20 0 1.00e+00 Zfand2b
Right kidney weight 54.05 1 1 20 0 1.00e+00 Zfand2b
Tail length 125.62 1 1 20 0 1.00e+00 Zfand2b
Length with tail 4.78 1 0 0 0 1.00e+00 Zfand2b
Length without tail 77.43 1 1 20 0 1.00e+00 Zfand2b
Liver weight, right 17.57 1 1 20 0 1.00e+00 Zfand2b
Parametrial fat weight 9.99 1 0 0 0 1.00e+00 Zfand2b
Retroperitoneal fat weight 3.85 4 0 0 1 2.62e-04 Coch Egln3 G2e3 Zfand2b
Intraocular pressure 51.69 1 1 20 0 1.00e+00 Zfand2b
Number of licking bursts 32.5 1 1 20 0 1.00e+00 Zfand2b
Food consumed during 24 hour testing period 15.78 1 0 0 0 1.00e+00 Zfand2b
Times rat made contact with spout 9.25 1 0 0 0 1.00e+00 Zfand2b
Mean time between licks in bursts 9.22 1 0 0 0 1.00e+00 Zfand2b
Mean num. licks in bursts 18.13 1 0 0 0 1.00e+00 Zfand2b
Std. dev. time between licks in bursts 12.12 1 0 0 0 1.00e+00 Zfand2b
Water consumed over 24 hours 34.33 1 1 20 0 1.00e+00 Zfand2b
Patch foraging indifference point 0 sec 9.69 2 0 0 0 1.00e+00 Egln3 Zfand2b
Patch foraging indifference point AUC 17.3 2 1 20 0 1.00e+00 Coch Zfand2b
Indifference point function ln k 54.42 1 1 20 0 1.00e+00 Zfand2b
Indifference point function log k 54.42 1 1 20 0 1.00e+00 Zfand2b
Patch foraging total patch changes 0 sec 12.4 3 1 20 0 1.00e+00 Coch Egln3 Zfand2b
Patch foraging total patch changes 12 sec 8.23 1 0 0 0 1.00e+00 Coch
Patch foraging total patch changes 18 sec 48.28 1 1 20 0 1.00e+00 Zfand2b
Patch foraging total patch changes 24 sec 77.61 1 1 20 0 1.00e+00 Zfand2b
Patch foraging total patch changes 6 sec 15.87 2 1 20 0 1.00e+00 Coch Zfand2b
Patch foraging water rate 0 sec 9.03 8 1 20 -0.96 2.30e-07 Coch Egln3 G2e3 Heatr5a Hectd1 LOC120103533 Nubpl Zfand2b
Patch foraging water rate 12 sec 69.49 1 1 20 0 1.00e+00 Zfand2b
Patch foraging water rate 18 sec 9.71 1 0 0 0 1.00e+00 Zfand2b
Patch foraging water rate 24 sec 12.61 1 0 0 0 1.00e+00 Zfand2b
Patch foraging water rate 6 sec 8.79 7 1 20 -0.97 1.90e-07 Coch G2e3 Heatr5a Hectd1 LOC120103533 Nubpl Zfand2b
Locomotor activity 8.5 3 0 0 0 1.00e+00 G2e3 Heatr5a Zfand2b
Locomotor testing distance 47.2 1 1 20 0 1.00e+00 Zfand2b
Locomotor testing rearing 99.51 1 1 20 0 1.00e+00 Zfand2b
Light reinforcement 1 19.25 1 1 20 0 1.00e+00 Zfand2b
Light reinforcement 2 6.57 1 0 0 0 1.00e+00 Zfand2b
Reaction time number correct 114.79 1 1 20 0 1.00e+00 Zfand2b
Reaction time mean minus median 179.03 1 1 20 0 1.00e+00 Zfand2b
Reaction time mean minus median AUC 232.47 1 1 20 0 1.00e+00 Zfand2b
Reaction time num false alarms 6.88 1 0 0 0 1.00e+00 Egln3
Reaction time num false alarms AUC 17.85 2 1 20 0 1.00e+00 Egln3 Zfand2b
Reaction time trials correct on left 114.79 1 1 20 0 1.00e+00 Zfand2b
Reaction time trials on left 106.69 1 1 20 0 1.00e+00 Zfand2b
Reaction time mean 36.11 1 1 20 0 1.00e+00 Zfand2b
Reaction time mean AUC 33.75 1 1 20 0 1.00e+00 Zfand2b
Median of all reaction times 17.65 1 0 0 0 1.00e+00 Zfand2b
Reaction time omissions 46.56 1 1 20 0 1.00e+00 Zfand2b
Reaction time false alarm rate 7.19 1 0 0 0 1.00e+00 Egln3
Reaction time premature initiations 41.6 1 1 20 0 1.00e+00 Zfand2b
Std. dev. reaction times 72.92 1 1 20 0 1.00e+00 Zfand2b
Reaction time trials completed 106.69 1 1 20 0 1.00e+00 Zfand2b
Reaction time trials AUC 108.76 1 1 20 0 1.00e+00 Zfand2b
Cocaine response after cond. corrected 12.71 1 0 0 0 1.00e+00 Zfand2b
Cocaine response after cond. not corrected 10.73 1 0 0 0 1.00e+00 Zfand2b
Saline control response 8.43 1 0 0 0 1.00e+00 Zfand2b
Conditioned reinforcement - actives 152.54 1 1 20 0 1.00e+00 Zfand2b
Conditioned reinforcement - inactives 135.63 1 1 20 0 1.00e+00 Zfand2b
Conditioned locomotion 13.93 1 0 0 0 1.00e+00 Zfand2b
Intermittent access intake day 1-15 change 156.77 1 1 20 0 1.00e+00 Zfand2b
Intermittent access intake escalation 117.41 1 1 20 0 1.00e+00 Zfand2b
Intermitt. access day 1 inactive lever presses 169.63 1 1 20 0 1.00e+00 Zfand2b
Intermitt. access day 15 inactive lever presses 294.26 1 1 20 0 1.00e+00 Zfand2b
Intermittent access day 1 total infusions 71.42 1 1 20 0 1.00e+00 Zfand2b
Intermittent access day 15 total infusions 35.39 1 1 20 0 1.00e+00 Zfand2b
Intermittent access terminal intake (last 3 days) 25.82 1 1 20 0 1.00e+00 Zfand2b
Intermittent access day 1 locomotion 26.47 1 1 20 0 1.00e+00 Zfand2b
Intermittent access day 15 total locomotion 93.08 1 1 20 0 1.00e+00 Zfand2b
Intermittent access total locomotion 12.43 1 0 0 0 1.00e+00 Zfand2b
Intermittent access standard deviation 442.51 1 1 20 0 1.00e+00 Zfand2b
Cocaine induced anxiety 125.35 1 1 20 0 1.00e+00 Zfand2b
Baseline Anxiety 393.92 1 1 20 0 1.00e+00 Zfand2b
Incentive Sensitization - Responses 309.83 1 1 20 0 1.00e+00 Zfand2b
Incentive Sensitization - Breakpoint 300.45 1 1 20 0 1.00e+00 Zfand2b
Progressive ratio test 1 active lever presses 26.41 1 1 20 0 1.00e+00 Zfand2b
Progressive ratio test 1 breakpoint 19.19 1 0 0 0 1.00e+00 Zfand2b
Progressive ratio test 2 active lever presses 109.22 1 1 20 0 1.00e+00 Zfand2b
Progressive ratio test 2 breakpoint 106.65 1 1 20 0 1.00e+00 Zfand2b
Progressive ratio test 2 inactive lever presses 63.47 1 1 20 0 1.00e+00 Zfand2b
Short access day 1 total inactive lever presses 21.93 1 0 0 0 1.00e+00 Zfand2b
Short access day 10 total inactive lever presses 43.04 1 1 20 0 1.00e+00 Zfand2b
Short access day 1 locomotion 129.19 1 1 20 0 1.00e+00 Zfand2b
Short access day 10 total locomotion 432.47 1 1 20 0 1.00e+00 Zfand2b
Short access total locomotion 209.96 1 1 20 0 1.00e+00 Zfand2b
Compulsive drug intake 68.39 1 1 20 0 1.00e+00 Zfand2b
One hour access (0.3 mA shock) 22.58 1 0 0 0 1.00e+00 Zfand2b
Number of responses in last shaping day 67.75 1 1 20 0 1.00e+00 Zfand2b
Locomotion velocity, session 7 8.31 2 0 0 0 1.00e+00 Hectd1 Nubpl
Bone: endosteal estimation 4.03 3 0 0 -1 2.25e-04 Coch Egln3 G2e3
Bone: endosteal perimeter 5.73 6 0 0 -1 1.76e-13 Coch G2e3 Heatr5a Hectd1 LOC120103533 Nubpl
Bone: marrow area 4.06 4 0 0 -1 4.61e-08 Coch Egln3 G2e3 LOC120103533
Bone: maximum diameter 8.28 6 0 0 -1 3.43e-15 Coch G2e3 Heatr5a Hectd1 LOC120103533 Nubpl
Bone: periosteal estimation 5.53 6 0 0 -1 5.28e-13 Coch G2e3 Heatr5a Hectd1 LOC120103533 Nubpl
Bone: periosteal perimeter 5.59 1 0 0 0 1.00e+00 G2e3
Distance traveled after self-admin 8.9 1 0 0 0 1.00e+00 Zfand2b
Delta time in open arm before/after self-admin 26.67 1 0 0 0 1.00e+00 Zfand2b
Active lever presses in extinction session 6 26.41 1 0 0 0 1.00e+00 Zfand2b
Time in closed arm before self-admin 44.32 1 1 20 0 1.00e+00 Zfand2b
Time in open arm before self-admin 24.67 1 0 0 0 1.00e+00 Zfand2b
Time to tail flick, vehicle, after self-admin 75.62 1 1 20 0 1.00e+00 Zfand2b
Time to tail flick, test, before self-admin 10.68 1 0 0 0 1.00e+00 Zfand2b
Delta time to tail flick, vehicle, before/after SA 74.6 1 1 20 0 1.00e+00 Zfand2b
Ambulatory time before self-admin 25.36 1 0 0 0 1.00e+00 Zfand2b
Area under the delay curve 20.08 2 1 20 0 1.00e+00 Egln3 Zfand2b
Delay disc. indifference point, 16s delay 69.03 1 1 20 0 1.00e+00 Zfand2b
Delay disc. indifference point, 24s delay 27.43 1 0 0 0 1.00e+00 Zfand2b
Delay disc. indifference point, 8s delay 74.24 1 1 20 0 1.00e+00 Zfand2b
Delay discount exponential model param 16.14 1 0 0 0 1.00e+00 Zfand2b
Delay discount hyperbolic model param 15.89 1 0 0 0 1.00e+00 Zfand2b
Fecal boli incidents, locomotor time 1 176.47 1 1 20 0 1.00e+00 Zfand2b
Time >=10cm from walls, locomotor time 1 79.04 1 1 20 0 1.00e+00 Zfand2b
Rest time, locomotor task time 1 11.47 1 0 0 0 1.00e+00 Zfand2b
Vertical activity count, locomotor time 1 97.7 1 1 20 0 1.00e+00 Zfand2b
Bouts of movement, locomotor time 2 23.9 1 0 0 0 1.00e+00 Zfand2b
Total resting periods, locomotor time 2 36.28 1 1 20 0 1.00e+00 Zfand2b
Rest time, locomotor task time 2 44.91 1 1 20 0 1.00e+00 Zfand2b
Distance moved, locomotor task time 2 83.87 1 1 20 0 1.00e+00 Zfand2b
Vertical activity count, locomotor time 2 13.16 1 0 0 0 1.00e+00 Zfand2b
Weight adjusted by age 9.91 1 0 0 0 1.00e+00 Zfand2b
Seeking ratio, delayed vs. immediate footshock 8.74 1 0 0 0 1.00e+00 Zfand2b
Locomotion in novel chamber post-restriction 14.04 1 0 0 0 1.00e+00 Zfand2b
Food seeking constrained by brief footshock 14.98 1 0 0 0 1.00e+00 Zfand2b
Run reversals in cocaine runway, females 36.45 1 1 20 0 1.00e+00 Zfand2b
Latency to leave start box in cocaine runway 34.23 1 1 20 0 1.00e+00 Zfand2b
Latency to leave start box in cocaine runway, F 31.9 1 1 20 0 1.00e+00 Zfand2b

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.62
Adipose alternative TSS 0 0 1.53
Adipose gene expression 0 0 1.51
Adipose isoform ratio 0 0 1.53
Adipose intron excision ratio 0 0 1.58
Adipose mRNA stability 0 0 1.54
BLA alternative polyA 0 0 1.61
BLA alternative TSS 0 0 1.56
BLA gene expression 0 0 1.54
BLA isoform ratio 0 0 1.59
BLA intron excision ratio 0 0 1.59
BLA mRNA stability 0 0 1.59
Brain alternative polyA 0 0 1.49
Brain alternative TSS 1 0 1.56
Brain gene expression 2 0 1.5
Brain isoform ratio 2 0 1.54
Brain intron excision ratio 0 0 1.59
Brain mRNA stability 1 0 1.48
Eye alternative polyA 0 0 1.49
Eye alternative TSS 0 0 1.13
Eye gene expression 0 0 1.48
Eye isoform ratio 0 0 1.48
Eye intron excision ratio 0 0 1.69
Eye mRNA stability 0 0 1.46
IL alternative polyA 0 0 1.61
IL alternative TSS 0 0 1.61
IL gene expression 1 0 1.5
IL isoform ratio 0 0 1.64
IL intron excision ratio 0 0 1.65
IL mRNA stability 0 0 1.6
LHb alternative polyA 0 0 1.62
LHb alternative TSS 0 0 1.41
LHb gene expression 0 0 1.54
LHb isoform ratio 0 0 1.61
LHb intron excision ratio 0 0 1.68
LHb mRNA stability 0 0 1.59
Liver alternative polyA 0 0 1.55
Liver alternative TSS 0 0 1.42
Liver gene expression 0 0 1.55
Liver isoform ratio 0 0 1.48
Liver intron excision ratio 1 0 1.68
Liver mRNA stability 0 0 1.49
NAcc alternative polyA 0 0 1.57
NAcc alternative TSS 0 0 1.48
NAcc gene expression 1 0 1.55
NAcc isoform ratio 0 0 1.59
NAcc intron excision ratio 0 0 1.52
NAcc mRNA stability 1 0 1.59
OFC alternative polyA 0 0 1.78
OFC alternative TSS 0 0 1.58
OFC gene expression 0 0 1.46
OFC isoform ratio 0 0 1.69
OFC intron excision ratio 0 0 1.57
OFC mRNA stability 0 0 1.6
PL alternative polyA 0 0 1.58
PL alternative TSS 0 0 1.52
PL gene expression 1 0 1.53
PL isoform ratio 0 0 1.54
PL intron excision ratio 1 0 1.58
PL mRNA stability 1 0 1.52
pVTA alternative polyA 0 0 1.59
pVTA alternative TSS 0 0 1.5
pVTA gene expression 0 0 1.54
pVTA isoform ratio 0 0 1.66
pVTA intron excision ratio 0 0 1.6
pVTA mRNA stability 0 0 1.56
RMTg alternative polyA 0 0 1.26
RMTg alternative TSS 0 0 1.47
RMTg gene expression 0 0 1.51
RMTg isoform ratio 0 0 1.48
RMTg intron excision ratio 0 0 1.3
RMTg mRNA stability 0 0 1.53