Hub : Traits

Delay discounting time to switch 0 sec

Delay discounting using a sequential patch depletion procedure, time it took the rat to switch water feeders with an experimenter-imposed delay of 0 sec

Tags: Behavior · Delay discounting

Project: p50_david_dietz

12 significantly associated models · 6 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 2.6e-20 8.5e-05 1.3e-46 -1230 Syt5
2 6 68065049 70118374 4 1 3.8e-08 1.1e-06 2.2e-01 94 G2e3
3 6 70976798 72372377 1 1 1.3e-07 2.8e-07 1.0e+00 100 Egln3

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 2.6 1 0 0 0.00 1.0e+00 Syt5
Glucose 12.1 1 0 0 0.00 1.0e+00 Syt5
Liver weight, left 10.2 1 0 0 0.00 1.0e+00 Syt5
Liver weight, right 11.2 1 0 0 0.00 1.0e+00 Syt5
Retroperitoneal fat weight 3.1 3 0 0 1.00 1.3e-03 G2e3 Egln3 Scfd1
Tibia length 7.5 1 0 0 0.00 1.0e+00 Syt5
Std. dev. time between licks in bursts 22.7 1 1 33 0.00 1.0e+00 Syt5
Indifference point 0 sec 7.0 2 0 0 0.00 1.0e+00 Egln3 Syt5
Indifference point AUC 10.5 1 0 0 0.00 1.0e+00 G2e3
Indifference point function ln k 8.8 1 0 0 0.00 1.0e+00 Syt5
Indifference point function log k 8.8 1 0 0 0.00 1.0e+00 Syt5
Delay discounting total patch changes 0 sec 6.5 3 0 0 0.00 1.0e+00 G2e3 Egln3 Syt5
Delay discounting total patch changes 12 sec 7.5 1 0 0 0.00 1.0e+00 G2e3
Delay discounting total patch changes 24 sec 10.3 1 0 0 0.00 1.0e+00 Syt5
Delay discounting total patch changes 6 sec 6.9 1 0 0 0.00 1.0e+00 G2e3
Delay discounting water rate 0 sec 6.9 6 0 0 -0.98 1.8e-07 G2e3 Egln3 Heatr5a Hectd1 Syt5 Scfd1
Delay discounting water rate 12 sec 22.1 1 1 33 0.00 1.0e+00 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0.00 1.0e+00 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0.00 1.0e+00 Syt5
Delay discounting water rate 6 sec 6.6 3 0 0 -0.82 2.5e-02 G2e3 Heatr5a Hectd1
Locomotor activity 6.2 3 0 0 0.72 2.8e-01 G2e3 Heatr5a Hectd1
Light reinforcement 1 21.6 1 1 33 0.00 1.0e+00 Syt5
Light reinforcement 2 21.6 1 1 33 0.00 1.0e+00 Syt5
Reaction time num false alarms 7.2 1 0 0 0.00 1.0e+00 Egln3
Reaction time num false alarms AUC 9.6 2 0 0 0.00 1.0e+00 Egln3 Syt5
Reaction time mean AUC 6.2 1 0 0 0.00 1.0e+00 Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.0e+00 Syt5
Reaction time false alarm rate 6.5 1 0 0 0.00 1.0e+00 Egln3
Social response proportion 8.0 1 0 0 0.00 1.0e+00 Syt5
Social time 18.1 1 0 0 0.00 1.0e+00 Syt5
Cocaine response after cond. corrected 18.2 1 0 0 0.00 1.0e+00 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0.00 1.0e+00 Syt5
Saline control response 13.2 1 0 0 0.00 1.0e+00 Syt5
Condit. Reinf. lever presses 9.9 1 0 0 0.00 1.0e+00 Syt5
Conditioned reinforcement - actives 22.3 1 0 0 0.00 1.0e+00 Syt5
Conditioned locomotion 15.1 1 0 0 0.00 1.0e+00 Syt5
Intermitt. access day 1 inactive lever presses 19.1 1 0 0 0.00 1.0e+00 Syt5
Intermitt. access day 15 inactive lever presses 38.5 1 1 33 0.00 1.0e+00 Syt5
Intermitt. access escalation Index 17.2 1 0 0 0.00 1.0e+00 Syt5
Intermittent access standard deviation 9.3 1 0 0 0.00 1.0e+00 Syt5
Post-drug Anxiety 10.2 1 0 0 0.00 1.0e+00 Syt5
Baseline Anxiety 26.3 1 1 33 0.00 1.0e+00 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0.00 1.0e+00 Syt5
Short access day 1 total inactive lever presses 24.4 1 1 33 0.00 1.0e+00 Syt5
Short access day 10 total locomotion 11.2 1 0 0 0.00 1.0e+00 Syt5
Short access total locomotion 13.1 1 0 0 0.00 1.0e+00 Syt5
One hour access (shock baseline) 24.4 1 1 33 0.00 1.0e+00 Syt5
Number of responses in last shaping day 9.8 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, session 1 61.5 1 1 33 0.00 1.0e+00 Syt5
Locomotion distance, session 1 22.4 1 1 33 0.00 1.0e+00 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0.00 1.0e+00 Syt5
Locomotion distance, session 3 8.7 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, session 7 7.7 1 0 0 0.00 1.0e+00 Hectd1
Locomotion distance, session 7 10.2 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, session 8 15.7 1 0 0 0.00 1.0e+00 Syt5
Locomotion distance, session 8 9.2 1 0 0 0.00 1.0e+00 Syt5
Time in familiar zone, hab. session 1 12.8 1 0 0 0.00 1.0e+00 Syt5
Total zone transitions, hab. session 1 25.5 1 1 33 0.00 1.0e+00 Syt5
Total locomotion distance, hab. session 1 19.3 1 1 33 0.00 1.0e+00 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0.00 1.0e+00 Syt5
Time in familiar zone, hab. session 2 14.1 1 0 0 0.00 1.0e+00 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0.00 1.0e+00 Syt5
Total locomotion distance, hab. session 2 10.7 1 0 0 0.00 1.0e+00 Syt5
Locomotion velocity, hab. session 2 13.6 1 0 0 0.00 1.0e+00 Syt5
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0.00 1.0e+00 Syt5
Pavlov. Cond. intertrial magazine entries 19.5 1 0 0 0.00 1.0e+00 Syt5
Pavlov. Cond. response bias 13.4 1 0 0 0.00 1.0e+00 Syt5
Bone: cortical porosity 7.7 1 0 0 0.00 1.0e+00 Syt5
Bone: elastic displacement 7.7 1 0 0 0.00 1.0e+00 Syt5
Bone: endosteal estimation 4.1 3 0 0 -1.00 8.4e-04 G2e3 Egln3 Scfd1
Bone: endosteal perimeter 5.7 4 0 0 -1.00 2.2e-10 G2e3 Heatr5a Hectd1 Scfd1
Bone: marrow area 4.2 3 0 0 -1.00 8.3e-04 G2e3 Egln3 Scfd1
Bone: maximum diameter 8.1 4 0 0 -1.00 3.1e-11 G2e3 Heatr5a Hectd1 Scfd1
Bone: periosteal estimation 5.5 4 0 0 -1.00 4.0e-10 G2e3 Heatr5a Hectd1 Scfd1
Bone: periosteal perimeter 5.2 1 0 0 0.00 1.0e+00 G2e3
Bone: post-yield work 11.6 1 0 0 0.00 1.0e+00 Syt5
Bone: tissue strength 13.1 1 0 0 0.00 1.0e+00 Syt5
Bone: trabecular tissue density 8.2 1 0 0 0.00 1.0e+00 Syt5
Distance traveled before self-admin 57.6 1 1 33 0.00 1.0e+00 Syt5
Distance traveled after self-admin 56.6 1 1 33 0.00 1.0e+00 Syt5
Delta time in open arm before/after self-admin 18.0 1 0 0 0.00 1.0e+00 Syt5
Diff in mean of infusions in LGA sessions 20.4 1 0 0 0.00 1.0e+00 Syt5
Extinction: sum of active levers before priming 36.5 1 1 33 0.00 1.0e+00 Syt5
Active lever presses in extinction session 6 17.9 1 0 0 0.00 1.0e+00 Syt5
Time in closed arm after self-admin 22.3 1 0 0 0.00 1.0e+00 Syt5
Time in open arm after self-admin 17.1 1 0 0 0.00 1.0e+00 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0.00 1.0e+00 Syt5
Time to tail flick, test, before self-admin 57.2 1 1 33 0.00 1.0e+00 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0.00 1.0e+00 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 33 0.00 1.0e+00 Syt5
Ambulatory time before self-admin 36.6 1 1 33 0.00 1.0e+00 Syt5
Ambulatory time after self-admin 61.3 1 1 33 0.00 1.0e+00 Syt5
Area under the delay curve 8.9 1 0 0 0.00 1.0e+00 Egln3
Delay disc. indifference point, 0s delay 28.0 1 1 33 0.00 1.0e+00 Syt5
Delay disc. indifference point, 16s delay 24.1 1 0 0 0.00 1.0e+00 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0.00 1.0e+00 Syt5
Bouts of movement, locomotor time 1 56.9 1 1 33 0.00 1.0e+00 Syt5
Total resting periods, locomotor time 1 37.3 1 1 33 0.00 1.0e+00 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0.00 1.0e+00 Syt5
Rest time, locomotor task time 2 9.1 1 0 0 0.00 1.0e+00 Syt5
Weight adjusted by age 8.3 1 0 0 0.00 1.0e+00 Syt5
Seeking ratio, delayed vs. immediate footshock 29.7 1 1 33 0.00 1.0e+00 Syt5
Locomotion in novel chamber 12.7 1 0 0 0.00 1.0e+00 Syt5
Progressive ratio 7.6 1 0 0 0.00 1.0e+00 Syt5
Food seeking constrained by brief footshock 133.4 1 1 33 0.00 1.0e+00 Syt5
Seeking ratio, punishment vs. effort 16.5 1 0 0 0.00 1.0e+00 Syt5
Run reversals in cocaine runway, females 8.3 1 0 0 0.00 1.0e+00 Syt5
Cd content in liver 7.7 1 0 0 0.00 1.0e+00 Syt5
Co content in liver 19.4 1 0 0 0.00 1.0e+00 Syt5
Sr content in liver 66.7 1 1 33 0.00 1.0e+00 Syt5
Zn content in liver 12.4 1 0 0 0.00 1.0e+00 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.5
Adipose alternative TSS 0 0.000 1.5
Adipose gene expression 0 0.000 1.5
Adipose isoform ratio 0 0.000 1.5
Adipose intron excision ratio 0 0.000 1.6
Adipose mRNA stability 0 0.000 1.5
BLA alternative polyA 0 0.000 1.5
BLA alternative TSS 0 0.000 1.5
BLA gene expression 2 0.033 1.5
BLA isoform ratio 0 0.000 1.5
BLA intron excision ratio 0 0.000 1.6
BLA mRNA stability 2 0.099 1.6
Brain alternative polyA 0 0.000 1.5
Brain alternative TSS 0 0.000 1.5
Brain gene expression 1 0.011 1.5
Brain isoform ratio 0 0.000 1.5
Brain intron excision ratio 0 0.000 1.6
Brain mRNA stability 1 0.023 1.5
Eye alternative polyA 0 0.000 1.6
Eye alternative TSS 0 0.000 1.3
Eye gene expression 0 0.000 1.5
Eye isoform ratio 0 0.000 1.4
Eye intron excision ratio 0 0.000 1.7
Eye mRNA stability 0 0.000 1.7
IL alternative polyA 0 0.000 1.6
IL alternative TSS 0 0.000 2.0
IL gene expression 0 0.000 1.5
IL isoform ratio 0 0.000 1.6
IL intron excision ratio 0 0.000 1.6
IL mRNA stability 0 0.000 1.6
LHb alternative polyA 0 0.000 1.4
LHb alternative TSS 0 0.000 1.5
LHb gene expression 1 0.031 1.5
LHb isoform ratio 0 0.000 1.6
LHb intron excision ratio 0 0.000 1.5
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.6
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.5
Liver isoform ratio 0 0.000 1.5
Liver intron excision ratio 0 0.000 1.6
Liver mRNA stability 1 0.041 1.5
NAcc alternative polyA 0 0.000 1.4
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 1 0.016 1.5
NAcc isoform ratio 0 0.000 1.5
NAcc intron excision ratio 1 0.033 1.6
NAcc mRNA stability 0 0.000 1.6
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.5
OFC gene expression 1 0.027 1.5
OFC isoform ratio 0 0.000 1.7
OFC intron excision ratio 0 0.000 1.5
OFC mRNA stability 0 0.000 1.6
PL alternative polyA 0 0.000 1.6
PL alternative TSS 0 0.000 1.5
PL gene expression 1 0.014 1.5
PL isoform ratio 0 0.000 1.5
PL intron excision ratio 0 0.000 1.6
PL mRNA stability 0 0.000 1.6

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.