Hub : Traits

Zn content in liver

Tags: Physiology · Liver

Project: vulpe_liver_2014

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	201865024	202832586	1	1	1.05e-10	1.23e-01	1.17e-03	Ccs
2	7	16845355	16970279	1	1	1.14e-12	NaN	NA	ENSRNOG00000064438

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	171.85	1	1	50	0	1e+00	ENSRNOG00000064438
Body weight	11.18	1	1	50	0	1e+00	ENSRNOG00000064438
Epididymis fat weight	136.19	1	1	50	0	1e+00	ENSRNOG00000064438
Glucose	6.57	1	0	0	0	1e+00	ENSRNOG00000064438
Heart weight	11.41	1	0	0	0	1e+00	ENSRNOG00000064438
Left kidney weight	62.74	1	1	50	0	1e+00	ENSRNOG00000064438
Right kidney weight	67.34	1	1	50	0	1e+00	ENSRNOG00000064438
Tail length	91.11	1	1	50	0	1e+00	ENSRNOG00000064438
Length with tail	3.99	1	0	0	0	1e+00	ENSRNOG00000064438
Length without tail	120.15	1	1	50	0	1e+00	ENSRNOG00000064438
Liver weight, left	23.57	1	1	50	0	1e+00	ENSRNOG00000064438
Liver weight, right	9.6	1	0	0	0	1e+00	ENSRNOG00000064438
Parametrial fat weight	26.35	1	1	50	0	1e+00	ENSRNOG00000064438
Retroperitoneal fat weight	4.2	1	0	0	0	1e+00	ENSRNOG00000064438
Intraocular pressure	29.37	1	1	50	0	1e+00	ENSRNOG00000064438
Extensor digitorum longus weight	39.16	1	1	50	0	1e+00	ENSRNOG00000064438
Soleus weight	21.94	1	1	50	0	1e+00	ENSRNOG00000064438
Tibialis anterior weight	95.96	1	1	50	0	1e+00	ENSRNOG00000064438
Tibia length	7.41	1	0	0	0	1e+00	ENSRNOG00000064438
Number of licking bursts	125.27	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Food consumed during 24 hour testing period	18.04	2	0	0	0	1e+00	Ccs ENSRNOG00000064438
Times rat made contact with spout	121.61	1	1	50	0	1e+00	ENSRNOG00000064438
Mean time between licks in bursts	90.53	1	1	50	0	1e+00	ENSRNOG00000064438
Mean num. licks in bursts	131.66	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Std. dev. time between licks in bursts	291.02	1	1	50	0	1e+00	ENSRNOG00000064438
Water consumed over 24 hours	8.62	2	0	0	0	1e+00	Ccs ENSRNOG00000064438
Indifference point 0 sec	21.27	1	1	50	0	1e+00	ENSRNOG00000064438
Indifference point AUC	66.71	1	1	50	0	1e+00	ENSRNOG00000064438
Indifference point function ln k	4.41	1	0	0	0	1e+00	ENSRNOG00000064438
Indifference point function log k	4.41	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 0 sec	20.12	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 12 sec	156.88	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 18 sec	277.74	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 24 sec	43.71	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting total patch changes 6 sec	144.99	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 0 sec	11.76	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 12 sec	44.18	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 18 sec	10.52	1	0	0	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 24 sec	100.9	1	1	50	0	1e+00	ENSRNOG00000064438
Delay discounting water rate 6 sec	70.2	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotor testing distance	14.01	1	0	0	0	1e+00	ENSRNOG00000064438
Locomotor testing rearing	23.89	1	1	50	0	1e+00	ENSRNOG00000064438
Light reinforcement 1	84.13	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time number correct	9.43	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time num false alarms	90.08	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time num false alarms AUC	128.16	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time trials correct on left	9.43	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time trials on left	10.33	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time mean	62.45	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time mean AUC	89.09	1	1	50	0	1e+00	ENSRNOG00000064438
Median of all reaction times	80.24	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time false alarm rate	104.16	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time premature initiation rate	47.3	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time premature initiations	49.75	1	1	50	0	1e+00	ENSRNOG00000064438
Std. dev. reaction times	26.97	1	1	50	0	1e+00	ENSRNOG00000064438
Reaction time trials completed	10.33	1	0	0	0	1e+00	ENSRNOG00000064438
Reaction time trials AUC	15.57	1	0	0	0	1e+00	ENSRNOG00000064438
Social responses	108.62	1	1	50	0	1e+00	ENSRNOG00000064438
Social time	7.75	1	0	0	0	1e+00	ENSRNOG00000064438
Cocaine response after cond. corrected	135.65	1	1	50	0	1e+00	ENSRNOG00000064438
Cocaine response after cond. not corrected	176.6	1	1	50	0	1e+00	ENSRNOG00000064438
Cocaine response before conditioning	28.56	1	1	50	0	1e+00	ENSRNOG00000064438
Saline control response	50.64	1	1	50	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	46.4	1	1	50	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	68.68	1	1	50	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active responses	11.07	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	20.59	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	60.53	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	173.36	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	216.69	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. index score	102.16	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	110.33	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	29.45	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	244.87	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. intertrial magazine entries	106.17	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	90.64	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	51.3	1	1	50	0	1e+00	ENSRNOG00000064438
Conditioned reinforcement - actives	18.52	1	0	0	0	1e+00	ENSRNOG00000064438
Conditioned locomotion	9.86	1	0	0	0	1e+00	ENSRNOG00000064438
Intermittent access intake day 1-15 change	103.99	1	1	50	0	1e+00	ENSRNOG00000064438
Intermittent access intake escalation	141.1	1	1	50	0	1e+00	ENSRNOG00000064438
Intermittent access intake escalation 2	42.55	1	1	50	0	1e+00	ENSRNOG00000064438
Intermitt. access day 1 inactive lever presses	30.61	1	1	50	0	1e+00	ENSRNOG00000064438
Intermitt. access escalation Index	9.22	1	0	0	0	1e+00	ENSRNOG00000064438
Intermittent access day 1 total infusions	52.87	1	1	50	0	1e+00	ENSRNOG00000064438
Intermittent access day 1 locomotion	27.14	1	1	50	0	1e+00	ENSRNOG00000064438
Post-drug Anxiety	20.58	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 active lever presses	11.8	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 breakpoint	10.37	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 1 inactive lever presses	10.82	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 2 active lever presses	12.24	1	0	0	0	1e+00	ENSRNOG00000064438
Progressive ratio test 2 breakpoint	61.59	1	1	50	0	1e+00	ENSRNOG00000064438
Short access day 10 total inactive lever presses	12.15	1	0	0	0	1e+00	ENSRNOG00000064438
Short access day 10 total infusions	24.04	1	1	50	0	1e+00	ENSRNOG00000064438
Short access day 1 locomotion	17.24	1	0	0	0	1e+00	ENSRNOG00000064438
Compulsive drug intake	45.38	1	1	50	0	1e+00	ENSRNOG00000064438
One hour access (0.3 mA shock)	10.45	1	0	0	0	1e+00	ENSRNOG00000064438
Context. condit. distance diff. score	240.19	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 1	190.79	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 1	609.62	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 2	139.57	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 2	1269.9	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 3	178.89	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 3	117.54	1	1	50	0	1e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 3	8.83	1	0	0	0	1e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 3	33.17	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, session 7	98.87	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 7	31.83	1	1	50	0	1e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 7	68.43	1	1	50	0	1e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 7	102.2	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion distance, session 8	171.7	1	1	50	0	1e+00	ENSRNOG00000064438
Degree of sensitization distance	198.53	1	1	50	0	1e+00	ENSRNOG00000064438
Degree of sensitization stereotypy	37.55	1	1	50	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	5.6	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	107.34	1	1	50	0	1e+00	ENSRNOG00000064438
Condit. Reinf. active responses	20.03	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	17.25	1	0	0	0	1e+00	ENSRNOG00000064438
Incentive salience index mean	15.58	1	0	0	0	1e+00	ENSRNOG00000064438
Condit. Reinf. lever presses	35.11	1	1	50	0	1e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 1	16.37	1	0	0	0	1e+00	ENSRNOG00000064438
Time in novel zone, hab. session 1	17.41	1	0	0	0	1e+00	ENSRNOG00000064438
Total zone transitions, hab. session 1	673.79	1	1	50	0	1e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 1	279.38	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 1	349.52	1	1	50	0	1e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 2	48.88	1	1	50	0	1e+00	ENSRNOG00000064438
Time in novel zone, hab. session 2	58.43	1	1	50	0	1e+00	ENSRNOG00000064438
Total zone transitions, hab. session 2	421.23	1	1	50	0	1e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 2	214.28	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 2	224.99	1	1	50	0	1e+00	ENSRNOG00000064438
Total zone transitions, NPP test	376.15	1	1	50	0	1e+00	ENSRNOG00000064438
Total locomotion distance, NPP test	269.3	1	1	50	0	1e+00	ENSRNOG00000064438
Locomotion velocity, NPP test	317.81	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	9.32	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	95.87	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	40.12	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. index score	51.85	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	16.59	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	16.14	1	0	0	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	61.65	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	88.12	1	1	50	0	1e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	52.36	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: apparent density	31.19	1	1	50	0	1e+00	ENSRNOG00000064438
Bone surface	41.33	1	1	50	0	1e+00	ENSRNOG00000064438
Bone volume	47.66	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: connectivity density	8.5	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: cortical porosity	188.54	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: cortical porosity	155.79	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: cortical thickness	8.79	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: cortical thickness	17.92	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: elastic displacement	28.18	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: endosteal estimation	18.44	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: final force	57.36	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: final moment	45.56	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: marrow area	15.29	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: maximum force	60.3	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: maximum moment	41.21	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: minimum diameter	86.67	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: periosteal estimation	10	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: periosteal perimeter	8.75	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: post-yield work	64.39	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Bone: stiffness	136.78	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: tissue strength	135.98	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: trabecular number	64.11	1	1	50	0	1e+00	ENSRNOG00000064438
Bone: trabecular spacing	5.66	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: trabecular thickness	13.82	1	0	0	0	1e+00	ENSRNOG00000064438
Bone: trabecular tissue density	66.58	1	1	50	0	1e+00	ENSRNOG00000064438
Distance traveled before self-admin	12.63	1	0	0	0	1e+00	ENSRNOG00000064438
Delta time in open arm before/after self-admin	40.25	1	1	50	0	1e+00	ENSRNOG00000064438
Extinction: sum of active levers before priming	12.19	1	0	0	0	1e+00	ENSRNOG00000064438
Active lever presses in extinction session 6	9.21	1	0	0	0	1e+00	ENSRNOG00000064438
Delta distance traveled before/after self-admin	11.33	1	0	0	0	1e+00	ENSRNOG00000064438
Delta ambulatory time before/after self-admin	4.67	1	0	0	0	1e+00	ENSRNOG00000064438
Time in closed arm before self-admin	77.96	1	1	50	0	1e+00	ENSRNOG00000064438
Time in closed arm after self-admin	40.16	1	1	50	0	1e+00	ENSRNOG00000064438
Time in open arm after self-admin	31.26	1	1	50	0	1e+00	ENSRNOG00000064438
Delta time to tail flick, vehicle, before/after SA	7.54	1	0	0	0	1e+00	ENSRNOG00000064438
Delta time to tail flick, test, before/after SA	20.03	1	0	0	0	1e+00	ENSRNOG00000064438
Ambulatory time before self-admin	5.66	1	0	0	0	1e+00	ENSRNOG00000064438
Fecal boli incidents, locomotor time 1	11.77	1	0	0	0	1e+00	ENSRNOG00000064438
Change in fecal boli incidents, locomotor task	8.82	1	0	0	0	1e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 1	19.54	1	0	0	0	1e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 2	27.2	1	1	50	0	1e+00	ENSRNOG00000064438
Total resting periods, locomotor time 2	6.01	1	0	0	0	1e+00	ENSRNOG00000064438
Rest time, locomotor task time 2	8.83	1	0	0	0	1e+00	ENSRNOG00000064438
Distance moved, locomotor task time 2	13.12	1	0	0	0	1e+00	ENSRNOG00000064438
Weight adjusted by age	24.99	1	1	50	0	1e+00	ENSRNOG00000064438
Seeking ratio, delayed vs. immediate footshock	5.34	1	0	0	0	1e+00	ENSRNOG00000064438
Locomotion in novel chamber	10.2	1	0	0	0	1e+00	ENSRNOG00000064438
Run reversals in cocaine runway, males	39.32	1	1	50	0	1e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway	18.78	1	0	0	0	1e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway, M	5.59	1	0	0	0	1e+00	ENSRNOG00000064438
Cd content in liver	122.53	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Co content in liver	89.26	2	2	100	0	1e+00	Ccs ENSRNOG00000064438
Fe content in liver	17.16	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
K content in liver	48.61	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Mg content in liver	22.35	1	0	0	0	1e+00	Ccs
Mn content in liver	105.91	2	1	50	0	1e+00	Ccs ENSRNOG00000064438
Na content in liver	11.48	1	0	0	0	1e+00	Ccs
Rb content in liver	31.44	1	1	50	0	1e+00	ENSRNOG00000064438
Se content in liver	41.05	2	2	100	0	1e+00	Ccs ENSRNOG00000064438
Sr content in liver	5.6	1	0	0	0	1e+00	ENSRNOG00000064438

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.19
Adipose	alternative TSS	0	0	1.04
Adipose	gene expression	0	0	1.08
Adipose	isoform ratio	0	0	1.1
Adipose	intron excision ratio	0	0	0.99
Adipose	mRNA stability	0	0	1.15
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	1.17
BLA	gene expression	0	0	1.07
BLA	isoform ratio	0	0	1.15
BLA	intron excision ratio	0	0	1.06
BLA	mRNA stability	0	0	1.16
Brain	alternative polyA	0	0	1.09
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.09
Brain	isoform ratio	0	0	1.07
Brain	intron excision ratio	0	0	1.07
Brain	mRNA stability	0	0	1.14
Eye	alternative polyA	0	0	1.5
Eye	alternative TSS	0	0	1.32
Eye	gene expression	0	0	1.15
Eye	isoform ratio	0	0	1.16
Eye	intron excision ratio	0	0	1.17
Eye	mRNA stability	0	0	1.15
IL	alternative polyA	0	0	1.05
IL	alternative TSS	0	0	1.18
IL	gene expression	0	0	1.07
IL	isoform ratio	0	0	1.07
IL	intron excision ratio	0	0	1.16
IL	mRNA stability	0	0	1.18
LHb	alternative polyA	0	0	1.15
LHb	alternative TSS	0	0	1.21
LHb	gene expression	0	0	1.09
LHb	isoform ratio	0	0	1.13
LHb	intron excision ratio	0	0	1.13
LHb	mRNA stability	0	0	1.14
Liver	alternative polyA	0	0	1.21
Liver	alternative TSS	0	0	1.09
Liver	gene expression	1	0	1.14
Liver	isoform ratio	0	0	1.12
Liver	intron excision ratio	0	0	1.14
Liver	mRNA stability	0	0	1.2
NAcc	alternative polyA	0	0	1.06
NAcc	alternative TSS	0	0	1.18
NAcc	gene expression	0	0	1.07
NAcc	isoform ratio	0	0	1.11
NAcc	intron excision ratio	0	0	1.03
NAcc	mRNA stability	0	0	1.16
OFC	alternative polyA	0	0	1.13
OFC	alternative TSS	0	0	1.1
OFC	gene expression	0	0	1.06
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1.08
OFC	mRNA stability	0	0	1.19
PL	alternative polyA	0	0	1.04
PL	alternative TSS	0	0	1.24
PL	gene expression	0	0	1.07
PL	isoform ratio	1	0	1.16
PL	intron excision ratio	0	0	1.02
PL	mRNA stability	0	0	1.16