Hub : Genes

Esrra

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000021139 0.06 0.04 5.3e-03 0.04 0.02 0.02 0.03 2.0e-04 1.2e-02 2.6e-03 2.2e-03
2 Liver gene expression ENSRNOG00000021139 0.03 0.02 8.1e-03 0.02 0.01 0 0.01 6.0e-03 2.3e-02 9.6e-02 2.5e-02
3 PL gene expression ENSRNOG00000021139 0.05 0.03 2.0e-03 0.01 0.02 0.01 0.01 7.9e-02 7.0e-03 4.4e-02 4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.61.83.01.50.2-1.7
BMI without tail0.40.71.60.2-0.8-1.3
Body weight0.94.011.5-0.70.2-3.4
Epididymis fat weight2.15.07.72.70.42.8
Glucose2.43.75.92.4-0.02.3
Heart weight2.53.56.81.6-1.22.6
Left kidney weight0.41.11.61.10.81.3
Right kidney weight0.51.43.10.91.80.5
Tail length1.13.35.1-2.3-0.8-2.0
Length with tail1.14.28.4-2.10.0-2.9
Length without tail0.61.33.1-0.70.5-1.8
Liver weight, left0.30.51.21.1-0.10.6
Liver weight, right0.61.01.21.1-1.10.7
Parametrial fat weight2.44.88.42.90.32.4
Retroperitoneal fat weight4.013.423.14.10.14.8
Intraocular pressure0.81.12.9-0.61.70.3
Extensor digitorum longus weight2.811.227.4-2.40.6-5.2
Soleus weight2.16.213.62.1-0.73.7
Tibialis anterior weight5.318.240.2-3.61.2-6.3
Tibia length1.64.69.6-0.33.1-2.0
Number of licking bursts0.20.20.3-0.20.5-0.6
Food consumed during 24 hour testing period0.50.60.9-0.71.0-0.6
Times rat made contact with spout0.80.91.5-1.2-0.6-0.9
Mean time between licks in bursts1.31.83.5-1.3-1.9-0.7
Mean num. licks in bursts0.30.30.7-0.4-0.80.3
Std. dev. time between licks in bursts1.21.43.9-0.5-2.00.4
Water consumed over 24 hours1.41.73.1-1.8-0.1-1.4
Indifference point 0 sec0.00.00.0-0.10.10.2
Indifference point AUC2.63.15.9-1.21.4-2.4
Indifference point function ln k6.28.715.32.1-2.53.9
Indifference point function log k6.28.715.32.1-2.53.9
Delay discounting total patch changes 0 sec0.10.10.2-0.5-0.40.1
Delay discounting total patch changes 12 sec2.73.67.5-1.60.8-2.7
Delay discounting total patch changes 18 sec0.60.91.5-0.60.9-1.2
Delay discounting total patch changes 24 sec2.02.54.5-1.70.5-2.1
Delay discounting total patch changes 6 sec0.30.40.9-0.5-0.3-1.0
Delay discounting time to switch 0 sec0.71.11.50.61.2-1.1
Delay discounting water rate 0 sec1.11.74.40.1-0.82.1
Delay discounting water rate 12 sec3.85.711.00.3-2.43.3
Delay discounting water rate 18 sec2.33.05.00.6-1.92.2
Delay discounting water rate 24 sec1.72.34.90.4-1.42.2
Delay discounting water rate 6 sec2.53.65.70.1-2.32.4
Locomotor activity1.42.23.70.1-1.91.7
Locomotor testing distance2.43.97.30.1-2.72.1
Locomotor testing rearing1.72.74.20.3-2.01.9
Light reinforcement 10.10.10.3-0.6-0.30.2
Light reinforcement 21.82.33.11.61.81.1
Reaction time number correct0.30.50.9-0.9-0.1-0.8
Reaction time mean minus median2.33.04.7-0.42.1-2.2
Reaction time mean minus median AUC1.51.93.0-0.81.4-1.7
Reaction time num false alarms1.41.95.1-0.4-2.30.7
Reaction time num false alarms AUC1.21.74.4-0.9-2.10.0
Reaction time trials correct on left0.30.50.9-0.9-0.1-0.8
Reaction time trials on left0.40.61.0-1.0-0.1-0.9
Reaction time mean0.60.82.10.41.4-0.2
Reaction time mean AUC0.60.92.40.41.5-0.2
Median of all reaction times0.50.61.30.71.10.3
Reaction time omissions0.60.71.4-0.70.6-1.2
Reaction time false alarm rate1.01.43.6-0.1-1.90.7
Reaction time premature initiation rate2.12.93.0-1.7-1.7-1.7
Reaction time premature initiations3.44.96.6-2.6-1.5-2.4
Std. dev. reaction times1.01.42.7-0.31.6-1.2
Reaction time trials completed0.40.61.0-1.0-0.1-0.9
Reaction time trials AUC0.30.40.7-0.8-0.3-0.6
Social response proportion0.60.61.2-0.30.8-1.1
Social responses0.60.81.4-1.2-0.0-0.9
Social time0.40.61.0-1.0-0.3-0.8
Conditioned locomotion0.50.61.4-0.7-0.1-1.2
Cocaine response after cond. corrected1.82.02.71.0-1.51.7
Cocaine response after cond. not corrected1.41.52.01.0-1.31.4
Cocaine response before conditioning0.81.01.5-0.61.0-1.2
Saline control response2.22.95.8-1.7-0.5-2.4
Condit. Reinf. active minus inactive responses0.60.71.20.91.10.4
Condit. Reinf. active-inactive response ratio2.42.53.71.91.61.1
Condit. Reinf. active responses0.10.20.50.20.7-0.2
Condit. Reinf. inactive responses0.70.81.2-1.1-0.8-0.8
Condit. Reinf. lever presses1.42.03.20.11.8-1.7
Condit. Reinf. lever reinforcers received0.30.51.0-0.11.0-0.6
Pavlov. Cond. lever latency0.60.81.5-0.6-1.20.7
Pavlov. Cond. magazine entry latency2.02.25.1-1.00.8-2.2
Pavlov. Cond. change in total contacts2.13.06.30.12.5-1.6
Pavlov. Cond. index score1.62.13.4-0.21.7-1.9
Pavlov. Cond. latency score1.31.72.50.11.6-1.6
Pavlov. Cond. lever contacts0.60.81.6-0.01.3-1.0
Pavlov. Cond. magazine entry number3.54.39.01.2-1.63.0
Pavlov. Cond. intertrial magazine entries0.40.51.20.6-0.11.1
Pavlov. Cond. lever-magazine prob. diff.1.82.44.3-0.41.6-2.1
Pavlov. Cond. response bias1.31.83.1-0.41.5-1.8
Conditioned reinforcement - actives1.21.23.00.81.70.4
Conditioned reinforcement - inactives3.13.55.11.61.62.3
Conditioned locomotion3.94.610.01.90.73.2
Intermittent access intake day 1-15 change0.60.61.80.11.30.3
Intermittent access intake escalation0.50.51.40.21.20.3
Intermittent access intake escalation 20.70.71.9-0.31.4-0.1
Intermitt. access day 1 inactive lever presses1.61.72.81.40.41.7
Intermitt. access day 15 inactive lever presses2.73.03.41.81.51.8
Intermitt. access escalation Index2.52.23.31.0-1.51.8
Intermittent access day 1 total infusions7.88.915.94.00.43.3
Intermittent access day 15 total infusions7.68.512.63.61.43.3
Intermittent access terminal intake (last 3 days)7.38.013.23.61.82.8
Intermittent access total infusions6.77.412.73.61.32.8
Intermittent access day 1 locomotion6.36.411.13.3-0.72.8
Intermittent access day 15 total locomotion4.54.87.02.61.32.4
Intermittent access total locomotion8.49.516.64.11.43.2
Intermittent access standard deviation0.70.80.90.71.00.9
Cocaine induced anxiety0.30.41.00.31.0-0.2
Post-drug Anxiety1.21.32.4-0.21.5-1.3
Baseline Anxiety1.21.32.4-1.2-0.3-1.5
Lifetime Intake6.06.711.93.50.72.8
Incentive Sensitization - Responses1.01.01.31.11.10.7
Incentive Sensitization - Breakpoint1.21.21.41.21.20.9
Progressive ratio test 1 active lever presses2.22.23.91.60.52.0
Progressive ratio test 1 breakpoint1.81.83.31.40.51.8
Progressive ratio test 1 inactive lever presses0.70.81.60.7-0.41.3
Progressive ratio test 2 active lever presses4.34.66.02.51.42.4
Progressive ratio test 2 breakpoint3.84.36.92.21.12.6
Progressive ratio test 2 inactive lever presses6.17.010.42.91.53.2
Total sessions with >9 infusions3.74.16.92.6-0.72.2
Short access day 1 total inactive lever presses3.33.77.02.0-0.52.6
Short access day 10 total inactive lever presses2.52.74.90.8-1.62.2
Short access day 1 total infusions4.04.26.92.6-0.32.4
Short access day 10 total infusions4.75.210.83.30.22.2
Short access total infusions3.63.97.62.8-0.32.0
Short access day 1 locomotion3.73.96.82.6-0.62.1
Short access day 10 total locomotion2.12.33.81.9-0.31.7
Short access total locomotion2.72.84.82.2-0.61.8
Compulsive drug intake4.94.97.9-2.8-1.9-1.8
One hour access (0.3 mA shock)6.77.813.13.10.93.6
One hour access (shock baseline)8.49.712.33.52.43.3
Number of responses in last shaping day0.70.71.40.2-0.91.2
Context. condit. distance diff. score1.21.42.51.0-0.91.6
Locomotion velocity, session 10.40.41.10.2-1.00.2
Locomotion distance, session 10.30.40.60.8-0.7-0.1
Locomotion velocity, session 20.80.92.5-0.5-0.0-1.6
Locomotion distance, session 20.20.30.70.1-0.8-0.4
Locomotion velocity, session 32.02.34.42.1-0.71.4
Locomotion distance, session 30.10.20.20.4-0.30.4
Stereotopy head waving bouts, day 32.42.94.72.2-1.01.7
Stereotopy head waving duration, day 31.21.52.31.5-0.41.4
Locomotion velocity, session 71.51.63.11.8-0.21.3
Locomotion distance, session 70.70.91.40.7-1.20.8
Stereotopy head waving bouts, day 70.80.91.41.21.10.4
Stereotopy head waving duration, day 70.70.91.50.21.2-1.1
Locomotion velocity, session 80.60.71.1-0.5-1.0-0.8
Locomotion distance, session 80.81.22.61.6-0.41.0
Degree of sensitization distance0.60.60.91.0-0.60.6
Degree of sensitization stereotypy0.91.02.30.51.5-0.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.4-0.2-0.4
Condit. Reinf. active-inactive response ratio0.30.30.7-0.9-0.1-0.4
Condit. Reinf. active responses0.00.00.10.20.10.0
Condit. Reinf. inactive responses0.70.81.81.30.40.6
Incentive salience index mean0.10.10.2-0.1-0.2-0.4
Condit. Reinf. lever presses0.10.20.20.50.4-0.4
Time in familiar zone, hab. session 10.20.20.30.5-0.10.6
Time in novel zone, hab. session 10.50.51.2-0.1-1.10.5
Total zone transitions, hab. session 10.20.30.6-0.30.2-0.8
Total locomotion distance, hab. session 10.71.01.81.3-0.01.0
Locomotion velocity, hab. session 10.20.20.50.70.10.4
Time in familiar zone, hab. session 21.01.12.6-0.8-1.6-0.1
Time in novel zone, hab. session 20.30.30.70.40.8-0.1
Total zone transitions, hab. session 20.20.20.50.4-0.2-0.7
Total locomotion distance, hab. session 20.50.71.21.1-0.60.6
Locomotion velocity, hab. session 20.70.92.01.4-0.20.8
Novel to familiar place preference ratio1.71.83.80.02.0-1.3
Novelty place preference1.31.33.00.11.7-0.9
Time in novel zone, NPP test0.90.92.10.21.4-0.8
Total zone transitions, NPP test0.60.82.3-0.20.3-1.5
Total locomotion distance, NPP test0.30.40.80.9-0.40.4
Locomotion velocity, NPP test0.10.20.40.6-0.10.2
Pavlov. Cond. lever latency0.10.10.3-0.2-0.30.5
Pavlov. Cond. magazine entry latency0.20.20.40.40.6-0.5
Pavlov. Cond. change in total contacts0.80.82.10.41.5-0.3
Pavlov. Cond. index score0.20.30.5-0.20.7-0.6
Pavlov. Cond. latency score0.10.10.20.00.4-0.4
Pavlov. Cond. lever contacts0.00.00.00.2-0.1-0.1
Pavlov. Cond. magazine entry number0.70.91.50.5-1.20.9
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.40.50.4
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.30.8-0.9
Pavlov. Cond. response bias0.30.30.6-0.20.8-0.6
Bone: apparent density0.30.51.11.00.5-0.4
Bone surface2.13.65.70.52.2-2.4
Bone volume1.42.44.71.12.2-1.2
Bone: connectivity density0.71.02.40.30.7-1.6
Bone: cortical apparent density0.70.91.8-1.3-0.2-0.9
Bone: cortical area0.50.71.2-0.11.1-1.0
Bone: cortical porosity0.00.00.0-0.20.1-0.2
Bone: cortical porosity0.30.30.6-0.60.0-0.8
Bone: cortical thickness2.44.06.1-2.4-0.3-2.5
Bone: cortical thickness1.01.21.8-1.1-1.3-0.8
Bone: cortical tissue density0.81.12.2-1.5-0.3-1.0
Bone: elastic displacement1.31.52.9-0.7-1.71.0
Bone: elastic work1.31.62.4-1.3-1.6-0.9
Bone: endosteal estimation2.34.910.43.20.62.0
Bone: endosteal perimeter3.36.813.33.61.72.1
Bone: final force0.91.63.8-0.20.9-2.0
Bone: final moment0.81.43.4-0.20.9-1.8
Bone: marrow area2.35.010.43.20.52.1
Bone: maximum diameter0.91.63.61.01.9-0.4
Bone: maximum force1.22.13.20.81.6-1.8
Bone: maximum moment1.01.72.80.71.4-1.7
Bone: minimum diameter1.93.57.32.70.61.7
Bone: periosteal estimation1.02.14.32.11.30.6
Bone: periosteal perimeter0.71.21.81.31.30.0
Bone: post-yield work4.15.610.03.22.50.3
Bone: stiffness1.32.13.10.51.8-1.7
Bone: tissue strength0.20.20.60.10.8-0.1
Bone: trabecular number0.71.12.00.91.4-0.6
Bone: trabecular spacing0.81.02.0-0.9-1.40.4
Bone: trabecular thickness0.81.01.71.30.41.0
Bone: trabecular tissue density1.21.74.01.00.12.0
Breakpoint value in progressive ratio session2.02.34.4-1.01.2-2.1
Distance traveled before self-admin0.80.91.80.01.3-0.9
Distance traveled after self-admin0.40.50.8-0.50.9-0.6
Delta time in closed arm before/after self-admin1.91.95.5-0.1-2.30.4
Delta time in open arm before/after self-admin1.71.63.5-0.71.9-0.9
Diff in mean of infusions in LGA sessions0.70.81.2-1.10.4-1.0
Extinction: sum of active levers before priming2.42.45.1-1.20.9-2.3
Active lever presses in extinction session 62.72.64.1-1.01.6-2.0
Delta distance traveled before/after self-admin0.30.30.8-0.3-0.90.2
Delta ambulatory time before/after self-admin0.50.51.4-0.4-1.20.2
Time in closed arm before self-admin0.60.71.80.31.3-0.3
Time in closed arm after self-admin0.50.51.10.3-1.00.6
Time in open arm before self-admin2.72.97.6-0.2-2.81.0
Time in open arm after self-admin0.40.41.1-1.0-0.3-0.2
Sum of active levers in priming session hrs 5-64.03.97.0-1.22.6-1.8
Time to tail flick, vehicle, before self-admin0.50.50.90.90.6-0.4
Time to tail flick, vehicle, after self-admin0.70.81.3-0.2-1.0-1.1
Time to tail flick, test, before self-admin1.91.82.31.5-1.21.4
Time to tail flick, test, after self-admin0.00.00.1-0.20.0-0.2
Delta time to tail flick, vehicle, before/after SA0.50.50.8-0.5-0.9-0.6
Delta time to tail flick, test, before/after SA3.12.84.2-2.01.1-1.7
Ambulatory time before self-admin1.41.53.70.11.9-0.8
Ambulatory time after self-admin0.60.61.60.51.30.2
Total heroin consumption3.64.38.4-2.00.7-2.9
Area under the delay curve0.30.30.50.7-0.70.3
Delay disc. indifference point, 0s delay1.41.51.91.3-1.40.9
Delay disc. indifference point, 16s delay0.60.60.90.90.40.9
Delay disc. indifference point, 2s delay0.30.30.80.9-0.10.4
Delay disc. indifference point, 24s delay0.60.51.1-0.7-1.1-0.0
Delay disc. indifference point, 4s delay0.80.82.20.2-1.50.4
Delay disc. indifference point, 8s delay0.60.61.60.4-1.30.3
Delay discount exponential model param0.20.20.5-0.50.7-0.1
Delay discount hyperbolic model param0.20.30.5-0.50.7-0.1
Fecal boli incidents, locomotor time 11.21.33.30.51.8-0.5
Change in fecal boli incidents, locomotor task1.51.54.00.2-2.00.6
Time >=10cm from walls, locomotor time 13.13.25.92.41.51.1
Bouts of movement, locomotor time 13.53.97.0-2.60.9-1.9
Total resting periods, locomotor time 12.73.05.0-2.21.1-1.7
Rest time, locomotor task time 10.30.31.00.00.01.0
Distance moved, locomotor task time 10.10.10.40.6-0.1-0.1
Vertical activity count, locomotor time 11.21.32.11.3-0.31.4
Time >=10cm from walls, locomotor time 20.70.72.1-0.11.4-0.4
Bouts of movement, locomotor time 20.60.71.1-1.00.2-0.9
Total resting periods, locomotor time 20.30.30.4-0.60.2-0.6
Rest time, locomotor task time 22.02.44.01.7-0.32.0
Distance moved, locomotor task time 21.21.42.1-1.40.3-1.4
Vertical activity count, locomotor time 20.80.91.8-1.3-1.0-0.1
Weight adjusted by age1.61.83.3-1.11.0-1.8
Seeking ratio, delayed vs. immediate footshock0.10.10.1-0.3-0.40.4
Locomotion in novel chamber3.64.45.82.31.42.4
Locomotion in novel chamber post-restriction1.72.04.01.50.32.0
Progressive ratio0.70.81.70.40.8-1.3
Food seeking constrained by brief footshock0.50.61.5-0.6-1.2-0.3
Seeking ratio, punishment vs. effort1.51.93.5-0.6-1.91.3
Run reversals in cocaine runway, females1.41.44.00.5-2.00.1
Run reversals in cocaine runway, males0.10.10.1-0.2-0.30.3
Latency to leave start box in cocaine runway0.60.71.61.30.20.6
Latency to leave start box in cocaine runway, F0.10.10.20.40.5-0.0
Latency to leave start box in cocaine runway, M0.70.61.41.2-0.10.6
Cd content in liver0.80.81.50.71.20.8
Co content in liver1.61.93.1-1.4-1.80.8
Cu content in liver0.40.40.8-0.90.1-0.7
Fe content in liver0.20.30.50.30.7-0.4
K content in liver0.30.30.70.4-0.2-0.8
Mg content in liver0.30.30.80.9-0.20.2
Mn content in liver1.61.83.1-0.71.4-1.8
Na content in liver0.40.51.0-0.20.6-1.0
Rb content in liver1.51.93.11.5-0.51.8
Se content in liver1.41.74.70.62.2-0.3
Sr content in liver3.23.04.9-1.80.9-2.2
Zn content in liver0.70.81.5-0.80.6-1.2