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chr10:87,162,021-89,011,911

Best TWAS P=8.866303e-09 · Best GWAS P=1.742587e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Acbd4	alternative polyA	ENSRNOT00000004163	0.57	0.48	enet	153	0.52	1.4e-67	5.2	5.2	1.8e-07	0.93	0.21	0.79	FALSE
2	Adipose	Acbd4	alternative polyA	ENSRNOT00000118852	0.59	0.47	enet	213	0.51	1.3e-65	5.2	-5.2	2.2e-07	-0.91	0.21	0.79	FALSE
3	Adipose	Acbd4	gene expression	ENSRNOG00000003108	0.77	0.53	enet	252	0.66	4.8e-97	5.2	5.3	8.9e-08	0.89	0.21	0.79	FALSE
4	Adipose	Acbd4	isoform ratio	ENSRNOT00000004163	0.56	0.46	enet	256	0.48	6.7e-61	5.2	5.3	1.3e-07	0.94	0.21	0.79	FALSE
5	Adipose	Acbd4	isoform ratio	ENSRNOT00000118852	0.57	0.47	enet	241	0.50	2.0e-64	5.2	-5.2	1.6e-07	-0.95	0.21	0.79	FALSE
6	Adipose	Fmnl1	mRNA stability	ENSRNOG00000003207	0.10	0.09	top1	1	0.09	3.2e-10	5.1	-5.1	2.7e-07	-0.90	0.23	0.77	FALSE
7	BLA	Acbd4	alternative polyA	ENSRNOT00000118852	0.32	0.25	enet	229	0.27	7.6e-15	3.3	-5.2	2.4e-07	-0.92	1.00	0.00	FALSE
8	Brain	Arhgap27	alternative TSS	ENSRNOT00000038836	0.13	0.07	top1	1	0.07	3.1e-07	5.1	5.1	2.7e-07	0.97	0.24	0.74	FALSE
9	Brain	Arhgap27	alternative TSS	ENSRNOT00000119071	0.12	0.07	top1	1	0.07	5.0e-07	5.2	-5.2	2.3e-07	-0.97	0.22	0.76	FALSE
10	Liver	Acbd4	mRNA stability	ENSRNOG00000003108	0.10	0.05	blup	2232	0.07	1.1e-08	5.1	5.2	2.4e-07	0.88	0.33	0.67	FALSE
11	Liver	Dcakd	mRNA stability	ENSRNOG00000021682	0.03	0.02	top1	1	0.02	1.4e-03	5.1	5.1	2.7e-07	0.87	0.07	0.06	FALSE
12	OFC	Gfap	gene expression	ENSRNOG00000002919	0.28	0.14	lasso	4	0.19	2.7e-05	5.2	-5.2	2.2e-07	-0.55	0.30	0.68	FALSE
13	OFC	Acbd4	intron excision ratio	chr10:88050047:88050282	0.27	0.14	top1	1	0.14	3.5e-04	5.1	5.1	2.7e-07	0.90	0.12	0.08	FALSE
14	PL	Fmnl1	gene expression	ENSRNOG00000003207	0.21	0.18	top1	1	0.18	4.4e-05	5.2	5.2	1.9e-07	0.97	0.11	0.09	FALSE
15	PL2	Acbd4	mRNA stability	ENSRNOG00000003108	0.33	0.02	enet	108	0.09	2.0e-05	3.4	-5.8	8.9e-09	-0.95	0.50	0.41	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.