Hub : Traits

light_reinforcement_lr_active

Light reinforcement, active snout-poke responses for 5-sec light onset in the last three 18-minute sessions during the light reinforcement phase for males and females [n]

Project: p50_david_dietz

111 significantly associated models · 25 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 3.2e-10 5.1e-02 8.6e-02 22 Syt5
2 6 36233832 37621623 1 1 1.5e-07 7.1e-08 4.8e-37 -457 Lratd1
3 19 17307470 20307530 12 2 8.3e-09 3.1e-09 1.0e+00 100 Sall1 Zfp423
4 19 22559764 24711172 11 1 1.8e-08 2.6e-08 1.0e+00 100 Cacna1a

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
glucose_mg_dl 12.1 1 0 0 0 1.0e+00 Syt5
Tibia length in mm 7.5 1 0 0 0 1.0e+00 Syt5
Std. dev. time between licks in bursts 22.8 1 1 20 0 1.0e+00 Syt5
Food consumed during 24 hour testing period 10.8 5 0 0 1 6.2e-07 Rad23a Gcdh Mri1 Cacna1a Cesl1
Average drop size 12.2 1 0 0 0 1.0e+00 Syt5
light_reinforcement_lr_relactive 12.3 25 1 20 1 1.4e-146 Cbln1 Trmt1 Nfix Gadd45gip1 Rad23a Gcdh Lratd1 Dhps Sall1 Cyld Nod2 Snx20 Nkd1 Brd7 Zfp423 Adcy7 Syt5 Tent4b Brme1 Mri1 Cacna1a NA Rnaseh2a NA Cesl1
Delay discounting water rate 0 sec 10.3 1 0 0 0 1.0e+00 Syt5
reaction_time_pinit_slope 9.7 1 0 0 0 1.0e+00 Syt5
reaction_time_peropfalsealarm_slope 11.6 1 0 0 0 1.0e+00 Syt5
reaction_time_meanrt_slope 15.7 1 0 0 0 1.0e+00 Syt5
reaction_time_devmedrt_slope 42.2 1 1 20 0 1.0e+00 Syt5
ccp_trial_3_saline_dist_mm 23.3 1 1 20 0 1.0e+00 Syt5
Conditioned locomotion 15.1 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc15 11.6 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc9 24.1 1 1 20 0 1.0e+00 Syt5
tautz: manual_mpc3 8.8 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc12 20.2 1 1 20 0 1.0e+00 Syt5
tautz: manual_spc14 8.9 1 0 0 0 1.0e+00 Syt5
tautz: manual_mpc4 23.9 1 1 20 0 1.0e+00 Syt5
tautz: manual_mpc5 23.6 1 1 20 0 1.0e+00 Syt5
tautz: manual_spc22 69.7 1 1 20 0 1.0e+00 Syt5
tautz: manual_mpc12 25.5 1 1 20 0 1.0e+00 Syt5
tautz: manual_mpc19 32.6 1 1 20 0 1.0e+00 Syt5
tautz: manual_spc10 19.2 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc23 9.1 3 0 0 0 1.0e+00 Cyld Nkd1 Syt5
tautz: manual_spc6 49.4 1 1 20 0 1.0e+00 Syt5
tautz: manual_spc5 17.8 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc3 11.2 1 0 0 0 1.0e+00 Syt5
tautz: manual_spc19 11.8 1 0 0 0 1.0e+00 Syt5
Ambulatory time at time1 of open field 36.6 1 1 20 0 1.0e+00 Syt5
The total number of resting periods in time1 37.4 1 1 20 0 1.0e+00 Syt5
punishment 133.8 1 1 20 0 1.0e+00 Syt5
Liver cobalt concentration 19.4 1 0 0 0 1.0e+00 Syt5
Liver zinc concentration 12.4 1 0 0 0 1.0e+00 Syt5

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.9
Adipose alternative TSS 0 0.000 1.8
Adipose gene expression 5 0.060 1.8
Adipose isoform ratio 0 0.000 1.8
Adipose intron excision ratio 1 0.034 1.7
Adipose mRNA stability 1 0.029 1.8
BLA alternative polyA 0 0.000 1.9
BLA alternative TSS 2 0.238 1.9
BLA gene expression 3 0.049 1.9
BLA isoform ratio 1 0.057 1.9
BLA intron excision ratio 2 0.067 1.8
BLA mRNA stability 5 0.247 1.9
Brain alternative polyA 0 0.000 1.9
Brain alternative TSS 2 0.116 1.7
Brain gene expression 8 0.088 1.8
Brain isoform ratio 0 0.000 1.8
Brain intron excision ratio 5 0.092 1.9
Brain mRNA stability 6 0.138 1.8
Eye alternative polyA 0 0.000 1.9
Eye alternative TSS 0 0.000 1.8
Eye gene expression 1 0.089 1.8
Eye isoform ratio 0 0.000 2.2
Eye intron excision ratio 1 0.163 1.7
Eye mRNA stability 0 0.000 2.1
IL alternative polyA 0 0.000 1.8
IL alternative TSS 0 0.000 1.8
IL gene expression 2 0.055 1.8
IL isoform ratio 0 0.000 1.7
IL intron excision ratio 0 0.000 1.8
IL mRNA stability 1 0.090 1.9
LHb alternative polyA 0 0.000 1.9
LHb alternative TSS 2 0.571 1.9
LHb gene expression 3 0.093 1.8
LHb isoform ratio 0 0.000 1.9
LHb intron excision ratio 0 0.000 2.0
LHb mRNA stability 2 0.193 1.8
Liver alternative polyA 0 0.000 1.9
Liver alternative TSS 0 0.000 1.7
Liver gene expression 4 0.056 1.8
Liver isoform ratio 3 0.125 1.7
Liver intron excision ratio 0 0.000 1.7
Liver mRNA stability 1 0.041 1.8
NAcc alternative polyA 0 0.000 1.9
NAcc alternative TSS 0 0.000 1.7
NAcc gene expression 3 0.091 1.8
NAcc isoform ratio 0 0.000 1.8
NAcc intron excision ratio 1 0.105 1.7
NAcc mRNA stability 1 0.092 1.9
NAcc2 alternative polyA 0 0.000 1.9
NAcc2 alternative TSS 4 0.546 2.0
NAcc2 gene expression 4 0.075 1.8
NAcc2 isoform ratio 0 0.000 1.9
NAcc2 intron excision ratio 5 0.189 1.9
NAcc2 mRNA stability 2 0.112 1.9
OFC alternative polyA 0 0.000 1.9
OFC alternative TSS 1 0.313 2.1
OFC gene expression 3 0.081 1.9
OFC isoform ratio 0 0.000 1.9
OFC intron excision ratio 1 0.100 1.8
OFC mRNA stability 0 0.000 1.8
PL alternative polyA 0 0.000 1.7
PL alternative TSS 0 0.000 1.8
PL gene expression 2 0.054 1.9
PL isoform ratio 1 0.115 2.0
PL intron excision ratio 0 0.000 1.8
PL mRNA stability 2 0.174 1.9
PL2 alternative polyA 0 0.000 1.8
PL2 alternative TSS 5 0.532 2.1
PL2 gene expression 5 0.078 1.9
PL2 isoform ratio 0 0.000 1.8
PL2 intron excision ratio 6 0.190 2.0
PL2 mRNA stability 4 0.164 1.8

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.