Hub : Traits

Light reinforcement 1

Light reinforcement, active snout-poke responses for 5-sec light onset in the last three 18-minute sessions during the light reinforcement phase for males and females [n]

Tags: Behavior · Light reinforcement

Project: p50_david_dietz

3 loci · 12 genes with independent associations · 62 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr9	75969545	77365260	1	1	3.19e-09	5.18e-03	1e+00	Zfand2b
2	chr19	17070407	19809408	42	7	8.66e-09	3.09e-09	1e+00	Cyld LOC102553576 Nkd1 Nod2 Sall1 Tent4b Zfp423
3	chr19	22565390	24944067	19	4	2.64e-08	2.64e-08	1e+00	Get3 LOC120098581 MAST1 Mri1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	8.3	0	1.00e+00	Zfand2b
BMI without tail	53.65	1	1	8.3	0	1.00e+00	Zfand2b
Epididymis fat weight	111.28	1	1	8.3	0	1.00e+00	Zfand2b
Heart weight	71.7	1	1	8.3	0	1.00e+00	Zfand2b
Left kidney weight	27.22	1	1	8.3	0	1.00e+00	Zfand2b
Right kidney weight	54.05	1	1	8.3	0	1.00e+00	Zfand2b
Tail length	125.62	1	1	8.3	0	1.00e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1.00e+00	Zfand2b
Length without tail	77.43	1	1	8.3	0	1.00e+00	Zfand2b
Liver weight, right	17.57	1	1	8.3	0	1.00e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1.00e+00	Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1.00e+00	Zfand2b
Intraocular pressure	51.69	1	1	8.3	0	1.00e+00	Zfand2b
Number of licking bursts	32.5	1	1	8.3	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	12.06	5	0	0	1	6.10e-07	Gadd45gip1 Gcdh Mri1 Syce2 Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1.00e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	8.3	0	1.00e+00	Zfand2b
Indifference point function ln k	54.42	1	1	8.3	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	8.3	0	1.00e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	8.3	0	1.00e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1.00e+00	Zfand2b
Locomotor testing distance	47.2	1	1	8.3	0	1.00e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	8.3	0	1.00e+00	Zfand2b
Light reinforcement 2	12.26	30	0	0	1	1.16e-171	Adcy7 Adgrl1 Brd7 Brme1 C19h19orf53 Cnep1r1 Cyld Dhps Gadd45gip1 Gcdh Get3 Heatr3 LOC102553576 LOC102555451 LOC103694298 LOC120098581 LOC120098586 LOC120098652 MAST1 Mri1 Nacc1 Nkd1 Nod2 Prdx2 Sall1 Snx20 Syce2 Tent4b Wdr83os Zfp423
Reaction time number correct	114.79	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean	36.11	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	8.3	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	46.56	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	8.3	0	1.00e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials completed	106.69	1	1	8.3	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	8.3	0	1.00e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	8.3	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	8.3	0	1.00e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	8.3	0	1.00e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	8.3	0	1.00e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	8.3	0	1.00e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1.00e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	8.3	0	1.00e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	8.3	0	1.00e+00	Zfand2b
Baseline Anxiety	393.92	1	1	8.3	0	1.00e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	8.3	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	8.3	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	8.3	0	1.00e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	8.3	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	8.3	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	8.3	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1.00e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	8.3	0	1.00e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	8.3	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	8.3	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	8.3	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Area under the delay curve	31.15	1	1	8.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	8.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	8.3	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	8.3	0	1.00e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	8.3	0	1.00e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	8.3	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1.00e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	8.3	0	1.00e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	8.3	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	8.3	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1.00e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	8.3	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	8.3	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	8.3	0	1.00e+00	Zfand2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.8
Adipose	alternative TSS	1	0	1.81
Adipose	gene expression	6	0.1	1.79
Adipose	isoform ratio	0	0	1.79
Adipose	intron excision ratio	0	0	1.69
Adipose	mRNA stability	0	0	1.76
BLA	alternative polyA	0	0	1.96
BLA	alternative TSS	1	0.1	1.88
BLA	gene expression	6	0.1	1.88
BLA	isoform ratio	2	0.1	1.85
BLA	intron excision ratio	3	0.1	1.89
BLA	mRNA stability	4	0.2	1.83
Brain	alternative polyA	2	0.1	1.88
Brain	alternative TSS	2	0	1.82
Brain	gene expression	8	0.1	1.84
Brain	isoform ratio	2	0	1.84
Brain	intron excision ratio	3	0.1	1.86
Brain	mRNA stability	3	0.1	1.83
Eye	alternative polyA	0	0	1.46
Eye	alternative TSS	1	0.3	2.37
Eye	gene expression	0	0	1.78
Eye	isoform ratio	0	0	2.07
Eye	intron excision ratio	0	0	1.88
Eye	mRNA stability	1	0.3	2.07
IL	alternative polyA	0	0	1.73
IL	alternative TSS	0	0	1.61
IL	gene expression	5	0.1	1.83
IL	isoform ratio	2	0.2	1.78
IL	intron excision ratio	0	0	1.76
IL	mRNA stability	0	0	1.82
LHb	alternative polyA	0	0	1.59
LHb	alternative TSS	0	0	1.57
LHb	gene expression	3	0.1	1.75
LHb	isoform ratio	0	0	1.65
LHb	intron excision ratio	1	0.1	1.86
LHb	mRNA stability	0	0	1.69
Liver	alternative polyA	1	0	1.81
Liver	alternative TSS	1	0	1.67
Liver	gene expression	4	0.1	1.79
Liver	isoform ratio	2	0.1	1.7
Liver	intron excision ratio	1	0	1.8
Liver	mRNA stability	4	0.1	1.78
NAcc	alternative polyA	0	0	1.81
NAcc	alternative TSS	1	0	1.82
NAcc	gene expression	7	0.1	1.82
NAcc	isoform ratio	2	0	1.87
NAcc	intron excision ratio	7	0.1	1.91
NAcc	mRNA stability	6	0.2	1.84
OFC	alternative polyA	0	0	1.62
OFC	alternative TSS	0	0	1.81
OFC	gene expression	2	0	1.84
OFC	isoform ratio	2	0.1	1.86
OFC	intron excision ratio	1	0.1	1.83
OFC	mRNA stability	0	0	1.8
PL	alternative polyA	2	0.1	1.92
PL	alternative TSS	2	0.1	1.86
PL	gene expression	8	0.1	1.85
PL	isoform ratio	2	0	1.88
PL	intron excision ratio	3	0.1	1.94
PL	mRNA stability	4	0.1	1.83
pVTA	alternative polyA	2	0.1	1.86
pVTA	alternative TSS	0	0	1.81
pVTA	gene expression	3	0.1	1.87
pVTA	isoform ratio	0	0	1.76
pVTA	intron excision ratio	0	0	1.91
pVTA	mRNA stability	0	0	1.88
RMTg	alternative polyA	0	0	1.55
RMTg	alternative TSS	0	0	1.57
RMTg	gene expression	1	0.1	1.82
RMTg	isoform ratio	0	0	1.68
RMTg	intron excision ratio	0	0	1.8
RMTg	mRNA stability	0	0	1.81