Hub : Traits

Light reinforcement 1

Light reinforcement, active snout-poke responses for 5-sec light onset in the last three 18-minute sessions during the light reinforcement phase for males and females [n]

Tags: Behavior · Light reinforcement

Project: p50_david_dietz

99 significantly associated models · 27 unique genes

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	68581504	69974370	1	1	3.2e-10	5.1e-02	8.6e-02	22	Syt5
2	6	36233832	37621623	1	1	1.5e-07	7.1e-08	4.8e-37	-457	Lratd1
3	7	16845355	16970279	1	1	2.3e-35	NaN	NA	NA	NA
4	19	17307470	20307530	12	2	2.0e-08	3.1e-09	1.0e+00	100	Sall1 Zfp423
5	19	22559764	24711172	12	4	3.3e-10	2.6e-08	1.0e+00	100	Trmt1 Gcdh MAST1 Mri1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
BMI without tail	106.7	1	1	11	0.00	1.0e+00	NA
Body weight	7.7	1	1	11	0.00	1.0e+00	NA
Epididymis fat weight	87.6	1	1	11	0.00	1.0e+00	NA
Glucose	12.1	1	0	0	0.00	1.0e+00	Syt5
Heart weight	11.4	1	0	0	0.00	1.0e+00	NA
Left kidney weight	37.5	1	1	11	0.00	1.0e+00	NA
Right kidney weight	41.9	1	1	11	0.00	1.0e+00	NA
Tail length	58.1	1	1	11	0.00	1.0e+00	NA
Length with tail	4.0	1	0	0	0.00	1.0e+00	NA
Length without tail	71.1	1	1	11	0.00	1.0e+00	NA
Liver weight, left	16.9	2	1	11	0.00	1.0e+00	Syt5 NA
Liver weight, right	10.4	2	0	0	0.00	1.0e+00	Syt5 NA
Parametrial fat weight	26.4	1	1	11	0.00	1.0e+00	NA
Retroperitoneal fat weight	4.2	1	0	0	0.00	1.0e+00	NA
Intraocular pressure	19.0	1	1	11	0.00	1.0e+00	NA
Extensor digitorum longus weight	25.8	1	1	11	0.00	1.0e+00	NA
Soleus weight	13.7	1	1	11	0.00	1.0e+00	NA
Tibialis anterior weight	59.9	1	1	11	0.00	1.0e+00	NA
Tibia length	7.5	2	0	0	0.00	1.0e+00	Syt5 NA
Number of licking bursts	155.0	1	1	11	0.00	1.0e+00	NA
Food consumed during 24 hour testing period	12.2	5	0	0	0.32	5.4e-01	Gcdh Mri1 Cacna1a NA Cesl1
Times rat made contact with spout	75.1	1	1	11	0.00	1.0e+00	NA
Mean time between licks in bursts	54.9	1	1	11	0.00	1.0e+00	NA
Mean num. licks in bursts	164.2	1	1	11	0.00	1.0e+00	NA
Std. dev. time between licks in bursts	126.1	2	2	22	0.00	1.0e+00	Syt5 NA
Indifference point 0 sec	18.7	1	1	11	0.00	1.0e+00	NA
Indifference point AUC	42.1	1	1	11	0.00	1.0e+00	NA
Indifference point function ln k	8.8	1	0	0	0.00	1.0e+00	Syt5
Indifference point function log k	8.8	1	0	0	0.00	1.0e+00	Syt5
Delay discounting total patch changes 0 sec	17.7	1	1	11	0.00	1.0e+00	NA
Delay discounting total patch changes 12 sec	102.7	1	1	11	0.00	1.0e+00	NA
Delay discounting total patch changes 18 sec	175.3	1	1	11	0.00	1.0e+00	NA
Delay discounting total patch changes 24 sec	22.3	2	1	11	0.00	1.0e+00	Syt5 NA
Delay discounting total patch changes 6 sec	98.5	1	1	11	0.00	1.0e+00	NA
Delay discounting time to switch 0 sec	55.9	1	1	11	0.00	1.0e+00	Syt5
Delay discounting water rate 0 sec	11.1	2	0	0	0.00	1.0e+00	Syt5 NA
Delay discounting water rate 12 sec	33.1	2	2	22	0.00	1.0e+00	Syt5 NA
Delay discounting water rate 18 sec	14.8	2	0	0	0.00	1.0e+00	Syt5 NA
Delay discounting water rate 24 sec	62.7	1	1	11	0.00	1.0e+00	NA
Delay discounting water rate 6 sec	44.2	1	1	11	0.00	1.0e+00	NA
Locomotor testing distance	11.5	1	0	0	0.00	1.0e+00	NA
Locomotor testing rearing	16.8	1	1	11	0.00	1.0e+00	NA
Light reinforcement 2	12.3	26	1	11	1.00	2.8e-128	Cbln1 Trmt1 Nfix Gadd45gip1 Calr Gcdh MAST1 Lratd1 Dhps Sall1 Cyld Nod2 Snx20 Nkd1 Brd7 Zfp423 Adcy7 Syt5 Tent4b Brme1 Mri1 NA Cacna1a NA NA Cesl1
Reaction time number correct	9.4	1	0	0	0.00	1.0e+00	NA
Reaction time num false alarms	56.4	1	1	11	0.00	1.0e+00	NA
Reaction time num false alarms AUC	56.5	2	1	11	0.00	1.0e+00	Syt5 NA
Reaction time trials correct on left	9.4	1	0	0	0.00	1.0e+00	NA
Reaction time trials on left	10.3	1	0	0	0.00	1.0e+00	NA
Reaction time mean	41.3	1	1	11	0.00	1.0e+00	NA
Reaction time mean AUC	58.0	1	1	11	0.00	1.0e+00	NA
Median of all reaction times	51.2	1	1	11	0.00	1.0e+00	NA
Reaction time false alarm rate	63.4	1	1	11	0.00	1.0e+00	NA
Reaction time premature initiation rate	32.1	1	1	11	0.00	1.0e+00	NA
Reaction time premature initiations	34.3	1	1	11	0.00	1.0e+00	NA
Std. dev. reaction times	27.0	1	1	11	0.00	1.0e+00	NA
Reaction time trials completed	10.3	1	0	0	0.00	1.0e+00	NA
Reaction time trials AUC	15.6	1	0	0	0.00	1.0e+00	NA
Social responses	74.3	1	1	11	0.00	1.0e+00	NA
Social time	18.1	1	0	0	0.00	1.0e+00	Syt5
Cocaine response after cond. corrected	58.0	2	1	11	0.00	1.0e+00	Syt5 NA
Cocaine response after cond. not corrected	73.7	2	1	11	0.00	1.0e+00	Syt5 NA
Cocaine response before conditioning	28.6	1	1	11	0.00	1.0e+00	NA
Saline control response	24.6	2	1	11	0.00	1.0e+00	Syt5 NA
Condit. Reinf. active minus inactive responses	29.4	1	1	11	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	40.7	1	1	11	0.00	1.0e+00	NA
Condit. Reinf. active responses	11.1	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. inactive responses	20.6	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. lever presses	9.9	1	0	0	0.00	1.0e+00	Syt5
Pavlov. Cond. lever latency	36.3	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	104.9	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. change in total contacts	130.1	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. index score	62.2	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. latency score	67.1	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. lever contacts	29.4	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	150.0	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. intertrial magazine entries	63.9	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. lever-magazine prob. diff.	55.1	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. response bias	30.8	1	1	11	0.00	1.0e+00	NA
Conditioned reinforcement - actives	20.4	2	0	0	0.00	1.0e+00	Syt5 NA
Conditioned locomotion	15.1	1	0	0	0.00	1.0e+00	Syt5
Intermittent access intake day 1-15 change	61.5	1	1	11	0.00	1.0e+00	NA
Intermittent access intake escalation	82.5	1	1	11	0.00	1.0e+00	NA
Intermittent access intake escalation 2	42.5	1	1	11	0.00	1.0e+00	NA
Intermitt. access day 1 inactive lever presses	24.8	2	1	11	0.00	1.0e+00	Syt5 NA
Intermitt. access day 15 inactive lever presses	38.5	1	1	11	0.00	1.0e+00	Syt5
Intermitt. access escalation Index	17.2	1	0	0	0.00	1.0e+00	Syt5
Intermittent access day 1 total infusions	32.7	1	1	11	0.00	1.0e+00	NA
Intermittent access day 1 locomotion	27.1	1	1	11	0.00	1.0e+00	NA
Post-drug Anxiety	20.6	1	0	0	0.00	1.0e+00	NA
Baseline Anxiety	26.3	1	1	11	0.00	1.0e+00	Syt5
Progressive ratio test 1 active lever presses	11.8	1	0	0	0.00	1.0e+00	NA
Progressive ratio test 2 active lever presses	12.2	1	0	0	0.00	1.0e+00	NA
Progressive ratio test 2 breakpoint	38.7	1	1	11	0.00	1.0e+00	NA
Short access day 1 total inactive lever presses	24.4	1	1	11	0.00	1.0e+00	Syt5
Short access day 10 total inactive lever presses	12.2	1	0	0	0.00	1.0e+00	NA
Short access day 10 total infusions	24.0	1	1	11	0.00	1.0e+00	NA
Short access day 1 locomotion	17.2	1	0	0	0.00	1.0e+00	NA
Short access day 10 total locomotion	11.2	1	0	0	0.00	1.0e+00	Syt5
Short access total locomotion	13.1	1	0	0	0.00	1.0e+00	Syt5
Compulsive drug intake	45.4	1	1	11	0.00	1.0e+00	NA
One hour access (0.3 mA shock)	10.4	1	0	0	0.00	1.0e+00	NA
One hour access (shock baseline)	24.4	1	1	11	0.00	1.0e+00	Syt5
Context. condit. distance diff. score	149.8	1	1	11	0.00	1.0e+00	NA
Locomotion velocity, session 1	99.0	2	2	22	0.00	1.0e+00	Syt5 NA
Locomotion distance, session 1	257.3	2	2	22	0.00	1.0e+00	Syt5 NA
Locomotion velocity, session 2	61.6	2	1	11	0.00	1.0e+00	Syt5 NA
Locomotion distance, session 2	776.0	1	1	11	0.00	1.0e+00	NA
Locomotion velocity, session 3	116.1	1	1	11	0.00	1.0e+00	NA
Locomotion distance, session 3	82.4	1	1	11	0.00	1.0e+00	NA
Stereotopy head waving duration, day 3	25.6	1	1	11	0.00	1.0e+00	NA
Locomotion velocity, session 7	66.3	1	1	11	0.00	1.0e+00	NA
Locomotion distance, session 7	17.6	2	1	11	0.00	1.0e+00	Syt5 NA
Stereotopy head waving bouts, day 7	42.6	1	1	11	0.00	1.0e+00	NA
Stereotopy head waving duration, day 7	63.4	1	1	11	0.00	1.0e+00	NA
Locomotion velocity, session 8	15.7	1	0	0	0.00	1.0e+00	Syt5
Locomotion distance, session 8	71.6	2	1	11	0.00	1.0e+00	Syt5 NA
Degree of sensitization distance	140.6	1	1	11	0.00	1.0e+00	NA
Degree of sensitization stereotypy	37.5	1	1	11	0.00	1.0e+00	NA
Condit. Reinf. active-inactive response ratio	65.1	1	1	11	0.00	1.0e+00	NA
Condit. Reinf. active responses	20.0	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. inactive responses	17.2	1	0	0	0.00	1.0e+00	NA
Incentive salience index mean	15.6	1	0	0	0.00	1.0e+00	NA
Condit. Reinf. lever presses	35.1	1	1	11	0.00	1.0e+00	NA
Time in familiar zone, hab. session 1	14.6	2	0	0	0.00	1.0e+00	Syt5 NA
Time in novel zone, hab. session 1	17.4	1	0	0	0.00	1.0e+00	NA
Total zone transitions, hab. session 1	285.6	2	2	22	0.00	1.0e+00	Syt5 NA
Total locomotion distance, hab. session 1	120.7	2	2	22	0.00	1.0e+00	Syt5 NA
Locomotion velocity, hab. session 1	149.8	2	1	11	0.00	1.0e+00	Syt5 NA
Time in familiar zone, hab. session 2	31.5	2	1	11	0.00	1.0e+00	Syt5 NA
Time in novel zone, hab. session 2	58.4	1	1	11	0.00	1.0e+00	NA
Total zone transitions, hab. session 2	256.1	1	1	11	0.00	1.0e+00	NA
Total locomotion distance, hab. session 2	92.3	2	1	11	0.00	1.0e+00	Syt5 NA
Locomotion velocity, hab. session 2	97.5	2	1	11	0.00	1.0e+00	Syt5 NA
Total zone transitions, NPP test	228.8	1	1	11	0.00	1.0e+00	NA
Total locomotion distance, NPP test	163.4	1	1	11	0.00	1.0e+00	NA
Locomotion velocity, NPP test	195.9	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry latency	41.1	2	1	11	0.00	1.0e+00	Syt5 NA
Pavlov. Cond. change in total contacts	40.1	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. index score	51.9	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. latency score	16.6	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. lever contacts	13.3	1	0	0	0.00	1.0e+00	NA
Pavlov. Cond. magazine entry number	61.6	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. intertrial magazine entries	19.5	1	0	0	0.00	1.0e+00	Syt5
Pavlov. Cond. lever-magazine prob. diff.	50.5	1	1	11	0.00	1.0e+00	NA
Pavlov. Cond. response bias	32.9	2	1	11	0.00	1.0e+00	Syt5 NA
Bone: apparent density	31.2	1	1	11	0.00	1.0e+00	NA
Bone surface	28.9	1	1	11	0.00	1.0e+00	NA
Bone volume	32.3	1	1	11	0.00	1.0e+00	NA
Bone: connectivity density	8.5	1	0	0	0.00	1.0e+00	NA
Bone: cortical porosity	109.3	1	1	11	0.00	1.0e+00	NA
Bone: cortical porosity	91.2	1	1	11	0.00	1.0e+00	NA
Bone: cortical thickness	8.8	1	0	0	0.00	1.0e+00	NA
Bone: cortical thickness	17.9	1	0	0	0.00	1.0e+00	NA
Bone: elastic displacement	28.2	1	1	11	0.00	1.0e+00	NA
Bone: endosteal estimation	12.7	1	1	11	0.00	1.0e+00	NA
Bone: final force	39.5	1	1	11	0.00	1.0e+00	NA
Bone: final moment	31.9	1	1	11	0.00	1.0e+00	NA
Bone: marrow area	10.6	1	1	11	0.00	1.0e+00	NA
Bone: maximum force	42.0	1	1	11	0.00	1.0e+00	NA
Bone: maximum moment	29.5	1	1	11	0.00	1.0e+00	NA
Bone: minimum diameter	57.3	1	1	11	0.00	1.0e+00	NA
Bone: periosteal estimation	10.0	1	0	0	0.00	1.0e+00	NA
Bone: periosteal perimeter	8.8	1	0	0	0.00	1.0e+00	NA
Bone: post-yield work	59.0	2	1	11	0.00	1.0e+00	Syt5 NA
Bone: stiffness	90.4	1	1	11	0.00	1.0e+00	NA
Bone: tissue strength	58.4	2	1	11	0.00	1.0e+00	Syt5 NA
Bone: trabecular number	39.4	1	1	11	0.00	1.0e+00	NA
Bone: trabecular thickness	13.8	1	0	0	0.00	1.0e+00	NA
Bone: trabecular tissue density	43.1	1	1	11	0.00	1.0e+00	NA
Distance traveled before self-admin	35.1	2	1	11	0.00	1.0e+00	Syt5 NA
Distance traveled after self-admin	56.6	1	1	11	0.00	1.0e+00	Syt5
Delta time in open arm before/after self-admin	25.6	3	1	11	0.00	1.0e+00	Syt5 Mri1 NA
Diff in mean of infusions in LGA sessions	20.4	1	0	0	0.00	1.0e+00	Syt5
Extinction: sum of active levers before priming	24.3	2	1	11	0.00	1.0e+00	Syt5 NA
Active lever presses in extinction session 6	17.9	1	0	0	0.00	1.0e+00	Syt5
Delta distance traveled before/after self-admin	11.3	1	0	0	0.00	1.0e+00	NA
Time in closed arm before self-admin	50.0	1	1	11	0.00	1.0e+00	NA
Time in closed arm after self-admin	31.2	2	1	11	0.00	1.0e+00	Syt5 NA
Time in open arm after self-admin	24.2	2	1	11	0.00	1.0e+00	Syt5 NA
Sum of active levers in priming session hrs 5-6	17.2	1	0	0	0.00	1.0e+00	Syt5
Time to tail flick, test, before self-admin	57.2	1	1	11	0.00	1.0e+00	Syt5
Delta time to tail flick, test, before/after SA	31.2	2	1	11	0.00	1.0e+00	Syt5 NA
Ambulatory time before self-admin	36.6	1	1	11	0.00	1.0e+00	Syt5
Ambulatory time after self-admin	61.3	1	1	11	0.00	1.0e+00	Syt5
Delay disc. indifference point, 0s delay	28.0	1	1	11	0.00	1.0e+00	Syt5
Delay disc. indifference point, 16s delay	24.1	1	0	0	0.00	1.0e+00	Syt5
Fecal boli incidents, locomotor time 1	11.8	1	0	0	0.00	1.0e+00	NA
Time >=10cm from walls, locomotor time 1	19.5	1	0	0	0.00	1.0e+00	NA
Bouts of movement, locomotor time 1	56.9	1	1	11	0.00	1.0e+00	Syt5
Total resting periods, locomotor time 1	37.3	1	1	11	0.00	1.0e+00	Syt5
Vertical activity count, locomotor time 1	24.2	1	0	0	0.00	1.0e+00	Syt5
Time >=10cm from walls, locomotor time 2	19.4	1	1	11	0.00	1.0e+00	NA
Distance moved, locomotor task time 2	13.1	1	0	0	0.00	1.0e+00	NA
Weight adjusted by age	25.0	1	1	11	0.00	1.0e+00	NA
Seeking ratio, delayed vs. immediate footshock	29.7	1	1	11	0.00	1.0e+00	Syt5
Locomotion in novel chamber	11.4	2	0	0	0.00	1.0e+00	Syt5 NA
Food seeking constrained by brief footshock	133.4	1	1	11	0.00	1.0e+00	Syt5
Seeking ratio, punishment vs. effort	16.5	1	0	0	0.00	1.0e+00	Syt5
Run reversals in cocaine runway, males	39.3	1	1	11	0.00	1.0e+00	NA
Latency to leave start box in cocaine runway	18.8	1	0	0	0.00	1.0e+00	NA
Cd content in liver	140.5	1	1	11	0.00	1.0e+00	NA
Co content in liver	61.9	2	1	11	0.00	1.0e+00	Syt5 NA
Fe content in liver	10.3	1	0	0	0.00	1.0e+00	NA
K content in liver	62.6	1	1	11	0.00	1.0e+00	NA
Mn content in liver	130.2	1	1	11	0.00	1.0e+00	NA
Rb content in liver	31.4	1	1	11	0.00	1.0e+00	NA
Se content in liver	47.0	1	1	11	0.00	1.0e+00	NA
Sr content in liver	66.7	1	1	11	0.00	1.0e+00	Syt5
Zn content in liver	29.2	2	1	11	0.00	1.0e+00	Syt5 NA

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Adipose	alternative polyA	0	0.000	1.9
Adipose	alternative TSS	0	0.000	1.8
Adipose	gene expression	5	0.060	1.8
Adipose	isoform ratio	0	0.000	1.8
Adipose	intron excision ratio	1	0.034	1.7
Adipose	mRNA stability	1	0.029	1.8
BLA	alternative polyA	0	0.000	1.9
BLA	alternative TSS	2	0.238	1.9
BLA	gene expression	3	0.049	1.9
BLA	isoform ratio	1	0.057	1.9
BLA	intron excision ratio	2	0.067	1.8
BLA	mRNA stability	5	0.247	1.9
Brain	alternative polyA	0	0.000	1.9
Brain	alternative TSS	2	0.116	1.7
Brain	gene expression	9	0.099	1.8
Brain	isoform ratio	0	0.000	1.8
Brain	intron excision ratio	5	0.092	1.9
Brain	mRNA stability	6	0.138	1.8
Eye	alternative polyA	0	0.000	1.9
Eye	alternative TSS	0	0.000	1.8
Eye	gene expression	1	0.089	1.8
Eye	isoform ratio	0	0.000	2.2
Eye	intron excision ratio	1	0.163	1.7
Eye	mRNA stability	0	0.000	2.1
IL	alternative polyA	0	0.000	1.8
IL	alternative TSS	0	0.000	1.8
IL	gene expression	2	0.055	1.8
IL	isoform ratio	0	0.000	1.7
IL	intron excision ratio	0	0.000	1.8
IL	mRNA stability	1	0.090	1.9
LHb	alternative polyA	0	0.000	1.9
LHb	alternative TSS	2	0.571	1.9
LHb	gene expression	3	0.093	1.8
LHb	isoform ratio	0	0.000	1.9
LHb	intron excision ratio	0	0.000	2.0
LHb	mRNA stability	2	0.193	1.8
Liver	alternative polyA	0	0.000	1.9
Liver	alternative TSS	0	0.000	1.7
Liver	gene expression	4	0.056	1.8
Liver	isoform ratio	3	0.125	1.7
Liver	intron excision ratio	0	0.000	1.7
Liver	mRNA stability	1	0.041	1.8
NAcc	alternative polyA	0	0.000	1.7
NAcc	alternative TSS	0	0.000	1.6
NAcc	gene expression	4	0.063	1.8
NAcc	isoform ratio	0	0.000	1.8
NAcc	intron excision ratio	5	0.163	1.9
NAcc	mRNA stability	3	0.133	1.9
OFC	alternative polyA	0	0.000	1.9
OFC	alternative TSS	1	0.313	2.1
OFC	gene expression	3	0.081	1.9
OFC	isoform ratio	0	0.000	1.9
OFC	intron excision ratio	1	0.100	1.8
OFC	mRNA stability	0	0.000	1.8
PL	alternative polyA	0	0.000	1.8
PL	alternative TSS	5	0.426	2.0
PL	gene expression	4	0.054	1.8
PL	isoform ratio	2	0.090	2.0
PL	intron excision ratio	5	0.140	1.9
PL	mRNA stability	4	0.137	1.9

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.