Hub : Traits

Time >=10cm from walls, locomotor time 1

Time spent at least 10 cm from the chamber walls in time 1

Tags: Behavior · Locomotion

Project: u01_suzanne_mitchell

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 24497174 25018277 1 1 6.6e-08 0.0038 1.0e+00 100 Rims1
2 15 26118407 27192736 1 1 2.4e-08 0.0164 1.7e-08 -453 AABR07017874.1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Right kidney weight 1.9 1 0 0 0 1 Rims1
Liver weight, right 3.2 1 0 0 0 1 Rims1
Delay discounting total patch changes 24 sec 4.4 1 0 0 0 1 AABR07017874.1
Delay discounting time to switch 0 sec 4.2 1 0 0 0 1 AABR07017874.1
Delay discounting water rate 0 sec 5.7 1 0 0 0 1 AABR07017874.1
Delay discounting water rate 6 sec 6.2 1 0 0 0 1 AABR07017874.1
Light reinforcement 2 7.7 1 0 0 0 1 Rims1
Conditioned reinforcement - actives 6.8 1 0 0 0 1 AABR07017874.1
Conditioned reinforcement - inactives 5.5 1 0 0 0 1 Rims1
Intermitt. access day 1 inactive lever presses 15.1 1 0 0 0 1 Rims1
Intermitt. access day 15 inactive lever presses 7.7 1 0 0 0 1 Rims1
Intermittent access day 1 total infusions 5.1 1 0 0 0 1 AABR07017874.1
Intermittent access day 15 total infusions 8.0 1 0 0 0 1 AABR07017874.1
Intermittent access total infusions 4.7 1 0 0 0 1 Rims1
Intermittent access standard deviation 6.0 1 0 0 0 1 AABR07017874.1
Post-drug Anxiety 8.8 1 0 0 0 1 AABR07017874.1
Baseline Anxiety 6.2 1 0 0 0 1 AABR07017874.1
Lifetime Intake 4.5 1 0 0 0 1 Rims1
Incentive Sensitization - Responses 8.4 1 0 0 0 1 Rims1
Incentive Sensitization - Breakpoint 6.3 1 0 0 0 1 Rims1
Progressive ratio test 1 active lever presses 11.7 1 0 0 0 1 Rims1
Progressive ratio test 1 breakpoint 14.1 1 0 0 0 1 Rims1
Progressive ratio test 2 active lever presses 14.2 1 0 0 0 1 Rims1
Progressive ratio test 2 breakpoint 16.4 1 0 0 0 1 Rims1
Short access day 10 total inactive lever presses 20.6 2 1 50 0 1 Rims1 AABR07017874.1
Short access total infusions 5.5 1 0 0 0 1 Rims1
One hour access (0.3 mA shock) 4.8 1 0 0 0 1 Rims1
Locomotion velocity, session 3 6.6 1 0 0 0 1 Rims1
Stereotopy head waving bouts, day 7 6.0 1 0 0 0 1 AABR07017874.1
Stereotopy head waving duration, day 7 4.7 1 0 0 0 1 AABR07017874.1
Degree of sensitization stereotypy 5.0 1 0 0 0 1 AABR07017874.1
Distance traveled before self-admin 5.8 1 0 0 0 1 Rims1
Distance traveled after self-admin 5.0 1 0 0 0 1 Rims1
Extinction: sum of active levers before priming 27.4 1 1 50 0 1 Rims1
Delta distance traveled before/after self-admin 12.2 1 0 0 0 1 Rims1
Delta ambulatory time before/after self-admin 5.3 1 0 0 0 1 Rims1
Time in closed arm after self-admin 7.5 1 0 0 0 1 Rims1
Time to tail flick, vehicle, before self-admin 9.4 1 0 0 0 1 Rims1
Ambulatory time before self-admin 6.3 1 0 0 0 1 AABR07017874.1
Total heroin consumption 9.4 1 0 0 0 1 AABR07017874.1
Bouts of movement, locomotor time 1 6.0 1 0 0 0 1 Rims1
Total resting periods, locomotor time 1 7.0 1 0 0 0 1 Rims1
Vertical activity count, locomotor time 1 6.1 1 0 0 0 1 Rims1
Time >=10cm from walls, locomotor time 2 6.2 1 0 0 0 1 AABR07017874.1
Bouts of movement, locomotor time 2 16.2 2 1 50 0 1 Rims1 AABR07017874.1
Total resting periods, locomotor time 2 30.9 1 1 50 0 1 Rims1
Rest time, locomotor task time 2 4.5 1 0 0 0 1 Rims1
Distance moved, locomotor task time 2 20.5 1 0 0 0 1 AABR07017874.1
Vertical activity count, locomotor time 2 5.1 1 0 0 0 1 AABR07017874.1
Locomotion in novel chamber 4.6 1 0 0 0 1 AABR07017874.1
Locomotion in novel chamber post-restriction 5.2 1 0 0 0 1 Rims1
Latency to leave start box in cocaine runway, M 8.8 1 0 0 0 1 AABR07017874.1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.07
Adipose alternative TSS 0 0.000 1.02
Adipose gene expression 0 0.000 0.99
Adipose isoform ratio 0 0.000 1.04
Adipose intron excision ratio 0 0.000 1.05
Adipose mRNA stability 0 0.000 0.99
BLA alternative polyA 0 0.000 0.99
BLA alternative TSS 0 0.000 0.99
BLA gene expression 0 0.000 0.99
BLA isoform ratio 0 0.000 1.08
BLA intron excision ratio 0 0.000 1.03
BLA mRNA stability 0 0.000 1.04
Brain alternative polyA 0 0.000 1.00
Brain alternative TSS 0 0.000 0.98
Brain gene expression 1 0.011 0.97
Brain isoform ratio 0 0.000 1.01
Brain intron excision ratio 0 0.000 0.98
Brain mRNA stability 0 0.000 0.98
Eye alternative polyA 0 0.000 1.21
Eye alternative TSS 0 0.000 0.88
Eye gene expression 0 0.000 1.04
Eye isoform ratio 0 0.000 0.96
Eye intron excision ratio 0 0.000 0.92
Eye mRNA stability 0 0.000 0.92
IL alternative polyA 0 0.000 1.06
IL alternative TSS 0 0.000 1.06
IL gene expression 0 0.000 0.95
IL isoform ratio 0 0.000 0.96
IL intron excision ratio 0 0.000 1.15
IL mRNA stability 0 0.000 0.97
LHb alternative polyA 0 0.000 0.99
LHb alternative TSS 0 0.000 1.23
LHb gene expression 0 0.000 0.98
LHb isoform ratio 0 0.000 0.99
LHb intron excision ratio 0 0.000 1.05
LHb mRNA stability 0 0.000 1.00
Liver alternative polyA 0 0.000 1.01
Liver alternative TSS 0 0.000 1.14
Liver gene expression 0 0.000 1.01
Liver isoform ratio 0 0.000 1.04
Liver intron excision ratio 0 0.000 1.04
Liver mRNA stability 0 0.000 0.99
NAcc alternative polyA 0 0.000 0.95
NAcc alternative TSS 0 0.000 1.07
NAcc gene expression 1 0.016 0.98
NAcc isoform ratio 0 0.000 1.00
NAcc intron excision ratio 0 0.000 1.03
NAcc mRNA stability 0 0.000 1.01
OFC alternative polyA 0 0.000 1.02
OFC alternative TSS 0 0.000 0.91
OFC gene expression 0 0.000 0.99
OFC isoform ratio 0 0.000 0.97
OFC intron excision ratio 0 0.000 1.10
OFC mRNA stability 0 0.000 1.06
PL alternative polyA 0 0.000 1.09
PL alternative TSS 0 0.000 1.02
PL gene expression 0 0.000 0.99
PL isoform ratio 0 0.000 1.02
PL intron excision ratio 0 0.000 1.08
PL mRNA stability 0 0.000 1.00

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.