Hub : Traits

Intermittent access standard deviation

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 significantly associated model · 1 unique gene

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 108584253 109479622 1 1 1.5e-09 0.018 0.00091 -97 Apeh

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Liver weight, left 4.0 1 0 0 0 1 Apeh
Parametrial fat weight 2.5 1 0 0 0 1 Apeh
Std. dev. time between licks in bursts 6.9 1 0 0 0 1 Apeh
Indifference point 0 sec 3.8 1 0 0 0 1 Apeh
Delay discounting total patch changes 18 sec 5.9 1 0 0 0 1 Apeh
Delay discounting total patch changes 6 sec 4.9 1 0 0 0 1 Apeh
Reaction time premature initiation rate 2.9 1 0 0 0 1 Apeh
Social time 3.4 1 0 0 0 1 Apeh
Saline control response 4.4 1 0 0 0 1 Apeh
Conditioned reinforcement - inactives 32.2 1 1 100 0 1 Apeh
Conditioned locomotion 5.3 1 0 0 0 1 Apeh
Intermittent access intake day 1-15 change 26.8 1 1 100 0 1 Apeh
Intermittent access intake escalation 21.2 1 0 0 0 1 Apeh
Intermittent access intake escalation 2 29.8 1 1 100 0 1 Apeh
Intermitt. access day 15 inactive lever presses 27.4 1 1 100 0 1 Apeh
Intermittent access day 15 total infusions 4.7 1 0 0 0 1 Apeh
Intermittent access total locomotion 3.5 1 0 0 0 1 Apeh
Cocaine induced anxiety 6.4 1 0 0 0 1 Apeh
Incentive Sensitization - Responses 8.7 1 0 0 0 1 Apeh
Incentive Sensitization - Breakpoint 8.8 1 0 0 0 1 Apeh
Progressive ratio test 1 active lever presses 9.9 1 0 0 0 1 Apeh
Progressive ratio test 1 breakpoint 10.2 1 0 0 0 1 Apeh
Progressive ratio test 1 inactive lever presses 8.5 1 0 0 0 1 Apeh
Progressive ratio test 2 inactive lever presses 41.5 1 1 100 0 1 Apeh
Total sessions with >9 infusions 12.6 1 0 0 0 1 Apeh
Short access day 1 total inactive lever presses 7.7 1 0 0 0 1 Apeh
Short access day 10 total inactive lever presses 40.3 1 1 100 0 1 Apeh
Short access day 10 total locomotion 6.4 1 0 0 0 1 Apeh
Short access total locomotion 10.7 1 0 0 0 1 Apeh
Compulsive drug intake 7.7 1 0 0 0 1 Apeh
Number of responses in last shaping day 12.0 1 0 0 0 1 Apeh
Novel to familiar place preference ratio 6.2 1 0 0 0 1 Apeh
Novelty place preference 7.0 1 0 0 0 1 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0 1 Apeh
Pavlov. Cond. lever latency 3.6 1 0 0 0 1 Apeh
Pavlov. Cond. magazine entry latency 5.4 1 0 0 0 1 Apeh
Pavlov. Cond. index score 4.4 1 0 0 0 1 Apeh
Pavlov. Cond. latency score 4.2 1 0 0 0 1 Apeh
Pavlov. Cond. magazine entry number 4.2 1 0 0 0 1 Apeh
Pavlov. Cond. lever-magazine prob. diff. 4.9 1 0 0 0 1 Apeh
Pavlov. Cond. response bias 5.3 1 0 0 0 1 Apeh
Bone: connectivity density 3.2 1 0 0 0 1 Apeh
Bone: cortical area 3.3 1 0 0 0 1 Apeh
Bone: maximum diameter 2.6 1 0 0 0 1 Apeh
Time to tail flick, test, before self-admin 4.0 1 0 0 0 1 Apeh
Ambulatory time before self-admin 10.3 1 0 0 0 1 Apeh
Cu content in liver 4.8 1 0 0 0 1 Apeh

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.03
Adipose alternative TSS 0 0.000 1.07
Adipose gene expression 0 0.000 1.07
Adipose isoform ratio 0 0.000 1.08
Adipose intron excision ratio 0 0.000 1.03
Adipose mRNA stability 0 0.000 1.08
BLA alternative polyA 0 0.000 1.03
BLA alternative TSS 0 0.000 0.99
BLA gene expression 0 0.000 1.07
BLA isoform ratio 0 0.000 1.05
BLA intron excision ratio 0 0.000 1.10
BLA mRNA stability 0 0.000 1.07
Brain alternative polyA 0 0.000 1.02
Brain alternative TSS 0 0.000 1.06
Brain gene expression 0 0.000 1.08
Brain isoform ratio 0 0.000 1.05
Brain intron excision ratio 0 0.000 1.01
Brain mRNA stability 0 0.000 1.05
Eye alternative polyA 0 0.000 0.94
Eye alternative TSS 0 0.000 1.05
Eye gene expression 0 0.000 1.09
Eye isoform ratio 0 0.000 1.19
Eye intron excision ratio 0 0.000 1.15
Eye mRNA stability 0 0.000 1.23
IL alternative polyA 0 0.000 1.01
IL alternative TSS 0 0.000 1.29
IL gene expression 0 0.000 1.05
IL isoform ratio 0 0.000 1.05
IL intron excision ratio 0 0.000 1.10
IL mRNA stability 0 0.000 0.96
LHb alternative polyA 0 0.000 1.02
LHb alternative TSS 0 0.000 1.14
LHb gene expression 0 0.000 1.07
LHb isoform ratio 0 0.000 1.08
LHb intron excision ratio 0 0.000 1.19
LHb mRNA stability 0 0.000 1.11
Liver alternative polyA 0 0.000 0.97
Liver alternative TSS 0 0.000 1.12
Liver gene expression 0 0.000 1.09
Liver isoform ratio 0 0.000 1.12
Liver intron excision ratio 0 0.000 1.06
Liver mRNA stability 0 0.000 1.06
NAcc alternative polyA 0 0.000 1.12
NAcc alternative TSS 0 0.000 1.11
NAcc gene expression 0 0.000 1.08
NAcc isoform ratio 0 0.000 1.08
NAcc intron excision ratio 0 0.000 1.07
NAcc mRNA stability 0 0.000 1.07
OFC alternative polyA 0 0.000 1.10
OFC alternative TSS 0 0.000 1.15
OFC gene expression 0 0.000 1.06
OFC isoform ratio 0 0.000 1.09
OFC intron excision ratio 0 0.000 1.11
OFC mRNA stability 0 0.000 1.05
PL alternative polyA 0 0.000 1.14
PL alternative TSS 0 0.000 1.08
PL gene expression 0 0.000 1.08
PL isoform ratio 0 0.000 1.08
PL intron excision ratio 0 0.000 1.12
PL mRNA stability 1 0.034 1.06

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.