Hub : Traits

Intermittent access standard deviation

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

1 locus · 1 gene with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr9	75969545	77564890	2	1	5.52e-104	4.55e-02	1e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	100	0	1e+00	Zfand2b
BMI without tail	53.65	1	1	100	0	1e+00	Zfand2b
Epididymis fat weight	111.28	1	1	100	0	1e+00	Zfand2b
Heart weight	71.7	1	1	100	0	1e+00	Zfand2b
Left kidney weight	27.22	1	1	100	0	1e+00	Zfand2b
Right kidney weight	54.05	1	1	100	0	1e+00	Zfand2b
Tail length	125.62	1	1	100	0	1e+00	Zfand2b
Length with tail	4.78	1	0	0	0	1e+00	Zfand2b
Length without tail	77.43	1	1	100	0	1e+00	Zfand2b
Liver weight, right	17.57	1	1	100	0	1e+00	Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1e+00	Zfand2b
Retroperitoneal fat weight	5.08	2	0	0	0	1e+00	Speg Zfand2b
Intraocular pressure	51.69	1	1	100	0	1e+00	Zfand2b
Tibialis anterior weight	1.65	1	0	0	0	1e+00	Zfand2b
Number of licking bursts	32.5	1	1	100	0	1e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1e+00	Zfand2b
Mean time between licks in bursts	6.87	2	0	0	0	1e+00	Speg Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	100	0	1e+00	Zfand2b
Patch foraging indifference point 0 sec	13.5	2	0	0	0	1e+00	Speg Zfand2b
Patch foraging indifference point AUC	14.78	2	1	100	0	1e+00	Speg Zfand2b
Indifference point function ln k	54.42	1	1	100	0	1e+00	Zfand2b
Indifference point function log k	54.42	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 0 sec	19.47	2	1	100	0	1e+00	Speg Zfand2b
Patch foraging total patch changes 12 sec	4.69	2	0	0	0	1e+00	Speg Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	100	0	1e+00	Zfand2b
Patch foraging total patch changes 24 sec	43.36	2	1	100	0	1e+00	Speg Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	100	0	1e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	100	0	1e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	100	0	1e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1e+00	Zfand2b
Locomotor testing distance	47.2	1	1	100	0	1e+00	Zfand2b
Locomotor testing rearing	51.64	2	1	100	0	1e+00	Speg Zfand2b
Light reinforcement 1	12.64	2	1	100	0	1e+00	Speg Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1e+00	Zfand2b
Reaction time number correct	114.79	1	1	100	0	1e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	100	0	1e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	100	0	1e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	100	0	1e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	100	0	1e+00	Zfand2b
Reaction time trials on left	106.69	1	1	100	0	1e+00	Zfand2b
Reaction time mean	36.11	1	1	100	0	1e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	100	0	1e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1e+00	Zfand2b
Reaction time omissions	46.56	1	1	100	0	1e+00	Zfand2b
Reaction time false alarm rate	3.92	1	0	0	0	1e+00	Zfand2b
Reaction time premature initiations	23.97	2	1	100	0	1e+00	Speg Zfand2b
Std. dev. reaction times	72.92	1	1	100	0	1e+00	Zfand2b
Reaction time trials completed	106.69	1	1	100	0	1e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	100	0	1e+00	Zfand2b
Social response proportion	6.02	2	0	0	0	1e+00	Speg Zfand2b
Cocaine response after cond. corrected	9.23	2	0	0	0	1e+00	Speg Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1e+00	Zfand2b
Pavlov. Cond. lever latency	4.98	1	0	0	0	1e+00	Speg
Pavlov. Cond. lever contacts	8.2	1	0	0	0	1e+00	Speg
Pavlov. Cond. response bias	7.56	1	0	0	0	1e+00	Speg
Conditioned reinforcement - actives	152.54	1	1	100	0	1e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	100	0	1e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1e+00	Zfand2b
Intermittent access intake day 1-15 change	85.53	2	1	100	0	1e+00	Speg Zfand2b
Intermittent access intake escalation	65.12	2	1	100	0	1e+00	Speg Zfand2b
Intermittent access intake escalation 2	11.13	1	0	0	0	1e+00	Speg
Intermitt. access day 1 inactive lever presses	169.63	1	1	100	0	1e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	294.26	1	1	100	0	1e+00	Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	100	0	1e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	100	0	1e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	100	0	1e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	100	0	1e+00	Zfand2b
Intermittent access day 15 total locomotion	52.61	2	1	100	0	1e+00	Speg Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	100	0	1e+00	Zfand2b
Baseline Anxiety	393.92	1	1	100	0	1e+00	Zfand2b
Incentive Sensitization - Responses	157.41	2	1	100	0	1e+00	Speg Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	100	0	1e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	100	0	1e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	100	0	1e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	100	0	1e+00	Zfand2b
Short access day 10 total locomotion	219.69	2	1	100	0	1e+00	Speg Zfand2b
Short access total locomotion	209.96	1	1	100	0	1e+00	Zfand2b
Compulsive drug intake	68.39	1	1	100	0	1e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	100	0	1e+00	Zfand2b
Locomotion distance, session 2	4.45	1	0	0	0	1e+00	Zfand2b
Pavlov. Cond. lever-magazine prob. diff.	4.63	1	0	0	0	1e+00	Speg
Bone: elastic displacement	5.56	1	0	0	0	1e+00	Zfand2b
Distance traveled before self-admin	5.58	1	0	0	0	1e+00	Zfand2b
Distance traveled after self-admin	8.9	1	0	0	0	1e+00	Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1e+00	Zfand2b
Delta ambulatory time before/after self-admin	6.19	1	0	0	0	1e+00	Zfand2b
Time in closed arm before self-admin	25.82	2	1	100	0	1e+00	Speg Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	41.99	2	1	100	0	1e+00	Speg Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1e+00	Zfand2b
Time to tail flick, test, after self-admin	6.91	2	0	0	0	1e+00	Speg Zfand2b
Delta time to tail flick, vehicle, before/after SA	41.4	2	1	100	0	1e+00	Speg Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1e+00	Zfand2b
Ambulatory time after self-admin	4.73	1	0	0	0	1e+00	Zfand2b
Area under the delay curve	31.15	1	1	100	0	1e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	100	0	1e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	100	0	1e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	100	0	1e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	100	0	1e+00	Zfand2b
Bouts of movement, locomotor time 1	6.19	1	0	0	0	1e+00	Zfand2b
Rest time, locomotor task time 1	11.47	1	0	0	0	1e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	100	0	1e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	100	0	1e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	100	0	1e+00	Zfand2b
Distance moved, locomotor task time 2	83.87	1	1	100	0	1e+00	Zfand2b
Vertical activity count, locomotor time 2	13.16	1	0	0	0	1e+00	Zfand2b
Weight adjusted by age	7.53	2	0	0	0	1e+00	Speg Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1e+00	Zfand2b
Seeking ratio, punishment vs. effort	4.29	1	0	0	0	1e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	100	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	100	0	1e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	100	0	1e+00	Zfand2b

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.1
Adipose	alternative TSS	0	0	1.05
Adipose	gene expression	0	0	1.07
Adipose	isoform ratio	0	0	1.04
Adipose	intron excision ratio	0	0	0.97
Adipose	mRNA stability	0	0	1.04
BLA	alternative polyA	0	0	1
BLA	alternative TSS	0	0	1.06
BLA	gene expression	0	0	1.07
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.03
BLA	mRNA stability	0	0	1.08
Brain	alternative polyA	0	0	1.01
Brain	alternative TSS	0	0	1.09
Brain	gene expression	0	0	1.05
Brain	isoform ratio	0	0	1.07
Brain	intron excision ratio	0	0	1.02
Brain	mRNA stability	0	0	1.05
Eye	alternative polyA	0	0	1.13
Eye	alternative TSS	0	0	0.96
Eye	gene expression	0	0	1.07
Eye	isoform ratio	0	0	1.14
Eye	intron excision ratio	0	0	1.15
Eye	mRNA stability	0	0	1.1
IL	alternative polyA	0	0	1.03
IL	alternative TSS	0	0	1.15
IL	gene expression	0	0	1.02
IL	isoform ratio	0	0	1.07
IL	intron excision ratio	0	0	1.15
IL	mRNA stability	0	0	0.97
LHb	alternative polyA	0	0	1.06
LHb	alternative TSS	0	0	1.13
LHb	gene expression	0	0	1.07
LHb	isoform ratio	0	0	1.1
LHb	intron excision ratio	0	0	1.12
LHb	mRNA stability	0	0	1.05
Liver	alternative polyA	0	0	1.08
Liver	alternative TSS	0	0	1.08
Liver	gene expression	0	0	1.09
Liver	isoform ratio	0	0	1.12
Liver	intron excision ratio	0	0	1
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	0	0	1.03
NAcc	alternative TSS	0	0	1.08
NAcc	gene expression	0	0	1.07
NAcc	isoform ratio	0	0	1.04
NAcc	intron excision ratio	0	0	1.05
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	1.07
OFC	alternative TSS	0	0	1.07
OFC	gene expression	0	0	1.05
OFC	isoform ratio	0	0	1.07
OFC	intron excision ratio	0	0	1.12
OFC	mRNA stability	0	0	0.98
PL	alternative polyA	0	0	1.04
PL	alternative TSS	1	0	1.08
PL	gene expression	0	0	1.07
PL	isoform ratio	0	0	1.08
PL	intron excision ratio	1	0	1.15
PL	mRNA stability	0	0	1.09
pVTA	alternative polyA	0	0	1.04
pVTA	alternative TSS	0	0	1.12
pVTA	gene expression	0	0	1.07
pVTA	isoform ratio	0	0	1.05
pVTA	intron excision ratio	0	0	1.08
pVTA	mRNA stability	0	0	1.12
RMTg	alternative polyA	0	0	1.06
RMTg	alternative TSS	0	0	1.11
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	1.1
RMTg	intron excision ratio	0	0	1.13
RMTg	mRNA stability	0	0	1.15