Average velocity of locomotion during novelty place preference test for males and females [meters/sec]
Project: p50_shelly_flagel_2014
33 significantly associated models · 7 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 133628030 | 136109284 | 3 | 1 | 2.2e-07 | 2.1e-07 | 0.059 | 87 | Cpeb1 |
| 2 | 1 | 140510980 | 142727457 | 3 | 2 | 4.5e-17 | 1.2e-17 | 1.000 | 100 | Grm5 Ctsc |
| 3 | 14 | 31927677 | 33323902 | 1 | 1 | 1.1e-10 | 2.1e-11 | 1.000 | 100 | Kit |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|---|---|---|---|---|---|---|
| dissection: UMAP 3 of all traits | 3.9 | 1 | 0 | 0 | 0.00 | 1.0e+00 | Cpeb1 |
| dissection: PC 2 of all traits | 5.2 | 2 | 0 | 0 | 0.00 | 1.0e+00 | Blm Cpeb1 |
| os_mean | 11.8 | 2 | 0 | 0 | -0.98 | 1.7e-08 | Grm5 Ctsc |
| Average time between licks in bursts | 8.0 | 1 | 0 | 0 | 1.00 | 1.9e-12 | Ctsc |
| light_reinforcement_lr_relactive | 18.3 | 3 | 2 | 50 | 1.00 | 1.2e-36 | Tyr Grm5 Ctsc |
| light_reinforcement_lr_active | 9.7 | 4 | 0 | 0 | 1.00 | 2.2e-27 | Blm Grm5 Ctsc Cpeb1 |
| Delay discounting water rate 0 sec | 8.0 | 2 | 0 | 0 | -0.99 | 9.6e-03 | Grm5 Ctsc |
| locomotor_testing_activity | 6.7 | 1 | 0 | 0 | 0.00 | 1.0e+00 | Kit |
| reaction_time_falsealarm | 12.0 | 2 | 0 | 0 | 0.99 | 1.0e-16 | Grm5 Ctsc |
| tautz: manual_spc7 | 8.0 | 1 | 0 | 0 | 0.00 | 1.0e+00 | Ctsc |
| tautz: manual_spc8 | 8.2 | 2 | 0 | 0 | -0.98 | 6.4e-05 | Grm5 Ctsc |
| tautz: manual_mpc12 | 7.9 | 3 | 0 | 0 | -0.99 | 2.2e-06 | Tyr Grm5 Ctsc |
| tautz: manual_mpc13 | 10.9 | 4 | 0 | 0 | -0.97 | 8.2e-07 | Blm Grm5 Ctsc Cpeb1 |
| tautz: manual_mpc6 | 9.1 | 1 | 0 | 0 | 0.00 | 1.0e+00 | Ctsc |
| Liver sodium concentration | 11.2 | 3 | 0 | 0 | -0.98 | 3.7e-08 | Tyr Grm5 Ctsc |
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| Adipose | alternative polyA | 2 | 0.094 | 1.6 |
| Adipose | alternative TSS | 0 | 0.000 | 1.5 |
| Adipose | gene expression | 0 | 0.000 | 1.4 |
| Adipose | isoform ratio | 2 | 0.071 | 1.6 |
| Adipose | intron excision ratio | 2 | 0.069 | 1.4 |
| Adipose | mRNA stability | 1 | 0.029 | 1.4 |
| BLA | alternative polyA | 2 | 0.167 | 1.6 |
| BLA | alternative TSS | 0 | 0.000 | 1.5 |
| BLA | gene expression | 2 | 0.033 | 1.4 |
| BLA | isoform ratio | 0 | 0.000 | 1.5 |
| BLA | intron excision ratio | 0 | 0.000 | 1.4 |
| BLA | mRNA stability | 1 | 0.049 | 1.4 |
| Brain | alternative polyA | 0 | 0.000 | 1.5 |
| Brain | alternative TSS | 0 | 0.000 | 1.5 |
| Brain | gene expression | 4 | 0.044 | 1.4 |
| Brain | isoform ratio | 1 | 0.032 | 1.4 |
| Brain | intron excision ratio | 0 | 0.000 | 1.4 |
| Brain | mRNA stability | 0 | 0.000 | 1.4 |
| Eye | alternative polyA | 0 | 0.000 | 1.6 |
| Eye | alternative TSS | 0 | 0.000 | 1.6 |
| Eye | gene expression | 1 | 0.089 | 1.5 |
| Eye | isoform ratio | 0 | 0.000 | 1.4 |
| Eye | intron excision ratio | 0 | 0.000 | 1.5 |
| Eye | mRNA stability | 0 | 0.000 | 1.6 |
| IL | alternative polyA | 0 | 0.000 | 1.5 |
| IL | alternative TSS | 0 | 0.000 | 1.4 |
| IL | gene expression | 1 | 0.027 | 1.5 |
| IL | isoform ratio | 0 | 0.000 | 1.4 |
| IL | intron excision ratio | 0 | 0.000 | 1.4 |
| IL | mRNA stability | 0 | 0.000 | 1.5 |
| LHb | alternative polyA | 0 | 0.000 | 1.4 |
| LHb | alternative TSS | 0 | 0.000 | 1.6 |
| LHb | gene expression | 1 | 0.031 | 1.4 |
| LHb | isoform ratio | 0 | 0.000 | 1.5 |
| LHb | intron excision ratio | 0 | 0.000 | 1.6 |
| LHb | mRNA stability | 1 | 0.097 | 1.4 |
| Liver | alternative polyA | 0 | 0.000 | 1.4 |
| Liver | alternative TSS | 0 | 0.000 | 1.5 |
| Liver | gene expression | 0 | 0.000 | 1.4 |
| Liver | isoform ratio | 0 | 0.000 | 1.4 |
| Liver | intron excision ratio | 0 | 0.000 | 1.4 |
| Liver | mRNA stability | 1 | 0.041 | 1.4 |
| NAcc | alternative polyA | 0 | 0.000 | 1.6 |
| NAcc | alternative TSS | 0 | 0.000 | 1.7 |
| NAcc | gene expression | 1 | 0.030 | 1.4 |
| NAcc | isoform ratio | 0 | 0.000 | 1.5 |
| NAcc | intron excision ratio | 0 | 0.000 | 1.6 |
| NAcc | mRNA stability | 1 | 0.092 | 1.5 |
| NAcc2 | alternative polyA | 0 | 0.000 | 1.5 |
| NAcc2 | alternative TSS | 0 | 0.000 | 1.5 |
| NAcc2 | gene expression | 2 | 0.037 | 1.4 |
| NAcc2 | isoform ratio | 0 | 0.000 | 1.5 |
| NAcc2 | intron excision ratio | 0 | 0.000 | 1.5 |
| NAcc2 | mRNA stability | 0 | 0.000 | 1.4 |
| OFC | alternative polyA | 0 | 0.000 | 1.5 |
| OFC | alternative TSS | 0 | 0.000 | 1.4 |
| OFC | gene expression | 1 | 0.027 | 1.5 |
| OFC | isoform ratio | 0 | 0.000 | 1.4 |
| OFC | intron excision ratio | 0 | 0.000 | 1.4 |
| OFC | mRNA stability | 1 | 0.093 | 1.5 |
| PL | alternative polyA | 0 | 0.000 | 1.6 |
| PL | alternative TSS | 0 | 0.000 | 1.6 |
| PL | gene expression | 2 | 0.054 | 1.5 |
| PL | isoform ratio | 0 | 0.000 | 1.4 |
| PL | intron excision ratio | 0 | 0.000 | 1.5 |
| PL | mRNA stability | 1 | 0.087 | 1.5 |
| PL2 | alternative polyA | 0 | 0.000 | 1.5 |
| PL2 | alternative TSS | 0 | 0.000 | 1.5 |
| PL2 | gene expression | 1 | 0.016 | 1.4 |
| PL2 | isoform ratio | 0 | 0.000 | 1.5 |
| PL2 | intron excision ratio | 0 | 0.000 | 1.4 |
| PL2 | mRNA stability | 1 | 0.041 | 1.4 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.