Hub : Genes

Sgsm2

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000027194	0.1200	0.0650	1.3e-14	0.077	0.103	0.107	0.077	7.2e-09	1.7e-11	7.4e-12	7.0e-09
2	Adipose	mRNA stability	ENSRNOG00000027194	0.0280	0.0230	2.1e-03	0.008	0.012	0.002	0.008	3.8e-02	1.6e-02	1.7e-01	3.5e-02
3	BLA	gene expression	ENSRNOG00000027194	0.0735	0.0615	7.3e-03	0.025	0.022	0.015	0.016	1.7e-02	2.3e-02	5.1e-02	4.4e-02
4	BLA	mRNA stability	ENSRNOG00000027194	0.4300	0.2600	8.2e-09	0.133	0.129	0.111	0.132	1.3e-07	2.1e-07	1.7e-06	1.6e-07
5	Brain	gene expression	ENSRNOG00000027194	0.1100	0.0650	2.8e-12	0.137	0.123	0.130	0.131	1.2e-12	1.9e-11	4.7e-12	3.9e-12
6	Brain	mRNA stability	ENSRNOG00000027194	0.2018	0.1000	0.0e+00	0.225	0.213	0.183	0.218	1.1e-20	1.7e-19	1.0e-16	6.0e-20
7	IL	gene expression	ENSRNOG00000027194	0.1590	0.1070	7.1e-03	0.089	0.060	0.019	0.056	3.7e-03	1.5e-02	1.2e-01	1.8e-02
8	IL	mRNA stability	ENSRNOG00000027194	0.3850	0.1620	5.4e-08	0.169	0.167	0.225	0.230	7.5e-05	8.0e-05	4.0e-06	3.0e-06
9	LHb	mRNA stability	ENSRNOG00000027194	0.1580	0.1140	4.5e-03	0.028	0.084	0.058	0.057	7.3e-02	5.1e-03	1.7e-02	1.8e-02
10	Liver	gene expression	ENSRNOG00000027194	0.0490	0.0550	6.8e-03	0.003	0.009	0.002	0.006	1.3e-01	3.0e-02	1.7e-01	6.2e-02
11	Liver	isoform ratio	ENSRNOT00000079926	0.0264	0.0197	1.2e-03	0.026	0.021	0.021	0.023	5.6e-04	1.7e-03	1.8e-03	1.2e-03
12	NAcc	mRNA stability	ENSRNOG00000027194	0.1396	0.0933	2.8e-08	0.108	0.096	0.105	0.102	2.0e-08	1.3e-07	3.1e-08	5.3e-08
13	OFC	gene expression	ENSRNOG00000027194	0.2152	0.1451	1.1e-03	0.146	0.084	0.131	0.121	2.5e-04	5.0e-03	5.4e-04	8.5e-04
14	OFC	mRNA stability	ENSRNOG00000027194	0.1919	0.1258	1.4e-03	0.117	0.131	0.143	0.140	1.0e-03	5.4e-04	2.9e-04	3.5e-04
15	PL	gene expression	ENSRNOG00000027194	0.2954	0.2169	3.7e-13	0.198	0.152	0.183	0.192	5.8e-15	1.2e-11	7.3e-14	1.4e-14
16	PL	mRNA stability	ENSRNOG00000027194	0.3137	0.1576	0.0e+00	0.262	0.254	0.246	0.252	5.6e-20	2.5e-19	1.1e-18	3.7e-19

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Condit. Reinf. inactive responses	6.3	7.4	8.5	-2.7	-2.8	-2.8	2.8	-2.8	2.7	-2.7	2.8	2.9	-1.4	-2.7	2.8	-2.9	2.7	-2.8	2.8
Condit. Reinf. inactive responses	5.8	7.2	8.9	-2.5	-2.7	-2.8	2.7	-2.7	2.7	-3.0	2.8	2.8	-1.1	-3.0	2.6	-2.7	2.7	-3.0	2.7
Tibialis anterior weight	5.4	18.8	36.0	-6.0	-5.7	-3.7	3.9	-3.9	3.8	-3.5	5.2	4.1	-5.8	-3.7	3.9	-3.9	3.4	-3.6	3.9
Intermittent access standard deviation	4.8	5.1	7.1	-0.8	-1.4	-2.6	2.4	-2.4	2.5	-2.6	1.7	2.4	1.2	-2.7	2.4	-2.4	2.6	-2.6	2.4
Extensor digitorum longus weight	4.7	18.8	29.4	-5.4	-5.3	-4.0	4.2	-4.3	4.1	-3.7	4.8	4.2	-4.5	-4.0	4.2	-4.3	3.9	-3.8	4.2
Time in novel zone, hab. session 2	4.7	4.8	7.1	2.7	2.6	2.2	-2.1	2.1	-2.3	2.0	-2.5	-2.2	2.0	1.9	-2.1	2.1	-2.1	1.8	-2.1
Intermitt. access escalation Index	4.5	4.1	5.8	0.3	1.0	2.3	-2.4	2.2	-2.2	2.1	-1.1	-2.0	-1.2	2.3	-2.3	2.4	-2.3	2.2	-2.4
Condit. Reinf. active-inactive response ratio	4.4	4.7	5.5	2.2	2.2	2.3	-2.2	2.2	-2.3	2.1	-2.3	-2.3	1.1	2.3	-2.2	2.2	-2.1	2.2	-2.2
Left kidney weight	4.1	11.7	14.2	3.8	3.7	3.6	-3.6	3.6	-3.5	3.0	-3.6	-3.3	2.5	3.1	-3.6	3.5	-3.3	3.1	-3.6
Right kidney weight	3.8	10.8	12.9	3.5	3.4	3.4	-3.5	3.6	-3.4	2.9	-3.4	-3.1	2.2	3.1	-3.5	3.4	-3.3	3.0	-3.5
Bone: cortical thickness	3.6	5.9	10.8	3.3	3.1	2.3	-2.2	2.0	-2.2	2.0	-3.0	-2.3	3.1	2.0	-2.3	2.2	-1.9	1.9	-2.2
Tail length	3.5	10.5	14.6	1.6	2.1	3.5	-3.7	3.6	-3.5	3.4	-2.5	-3.3	-1.2	3.5	-3.7	3.6	-3.8	3.5	-3.7
Locomotion velocity, session 3	3.5	4.0	7.3	2.7	2.6	1.9	-1.6	1.6	-2.0	1.9	-2.7	-2.1	2.2	1.9	-1.6	1.6	-1.4	2.0	-1.6
Intermittent access day 15 total infusions	3.4	3.9	5.5	-1.5	-1.8	-1.9	1.9	-2.0	2.1	-2.3	2.0	2.2	-0.1	-2.3	2.0	-1.9	2.1	-2.3	1.9
One hour access (shock baseline)	3.4	3.9	6.4	-1.5	-1.9	-1.8	1.8	-2.1	2.0	-2.5	2.0	2.3	-0.2	-2.3	1.9	-1.9	1.9	-2.4	1.8
Total zone transitions, hab. session 1	3.4	4.8	5.6	-2.3	-2.3	-2.3	2.2	-2.4	2.2	-2.2	2.1	2.2	-1.3	-2.1	2.3	-2.2	2.2	-2.2	2.2
Bone: connectivity density	3.4	5.3	10.7	-3.3	-3.0	-2.1	1.9	-1.9	2.0	-1.7	2.9	2.1	-3.2	-2.3	1.8	-1.9	1.7	-2.2	1.9
One hour access (0.3 mA shock)	3.2	3.8	4.7	-1.8	-2.0	-2.0	1.9	-2.2	2.0	-2.1	2.0	2.1	-0.8	-2.0	2.0	-1.9	1.9	-2.1	1.9
Conditioned reinforcement - actives	3.0	2.9	4.0	-1.9	-2.0	-1.5	1.6	-1.7	1.5	-1.9	2.0	1.9	-1.2	-1.7	1.6	-1.6	1.4	-1.9	1.6
Intraocular pressure	2.9	4.0	6.7	-1.2	-1.5	-2.3	1.9	-2.0	2.1	-2.6	1.9	2.3	0.6	-2.3	1.8	-2.0	2.2	-2.5	1.9
Bone: elastic work	2.9	3.8	7.0	2.6	2.5	1.8	-1.6	1.5	-1.9	1.8	-2.5	-2.0	2.4	1.8	-1.7	1.6	-1.4	1.7	-1.6
Intermittent access intake day 1-15 change	2.8	2.7	4.0	-1.0	-1.1	-1.9	1.7	-1.6	1.9	-1.8	1.4	1.7	0.5	-1.9	1.8	-1.8	2.0	-1.7	1.7
Bone volume	2.8	4.8	8.4	-2.9	-2.8	-2.0	1.8	-2.0	2.0	-2.0	2.8	2.2	-2.5	-2.0	1.8	-1.9	1.7	-2.2	1.8
K content in liver	2.8	2.8	3.7	1.2	1.4	1.9	-1.8	1.7	-1.8	1.8	-1.5	-1.9	-0.0	1.8	-1.8	1.9	-1.7	1.8	-1.8
Delay discounting time to switch 0 sec	2.6	3.9	4.9	1.8	2.0	2.0	-2.1	2.1	-2.0	2.1	-2.0	-2.1	0.7	1.9	-2.1	2.2	-2.0	2.2	-2.1
Time in familiar zone, hab. session 1	2.6	2.5	3.2	-1.5	-1.5	-1.8	1.7	-1.6	1.7	-1.5	1.5	1.6	-0.6	-1.5	1.8	-1.7	1.7	-1.6	1.7
Bone surface	2.5	4.4	8.0	-2.8	-2.7	-1.9	1.7	-1.9	1.9	-1.9	2.7	2.1	-2.5	-2.0	1.7	-1.8	1.7	-2.1	1.7
Bone: trabecular number	2.5	3.9	8.0	-2.8	-2.6	-1.8	1.6	-1.7	1.7	-1.4	2.5	1.8	-2.8	-1.9	1.5	-1.6	1.5	-1.9	1.6
Na content in liver	2.5	2.7	4.2	2.0	2.0	1.7	-1.6	1.4	-1.5	1.4	-1.9	-1.6	1.7	1.5	-1.5	1.6	-1.3	1.5	-1.6
Condit. Reinf. lever reinforcers received	2.4	3.4	5.5	-1.7	-2.0	-1.8	1.6	-1.7	1.8	-2.3	2.1	2.1	-0.7	-2.2	1.6	-1.7	1.6	-2.2	1.6
Intermittent access terminal intake (last 3 days)	2.4	2.6	3.6	-1.7	-1.8	-1.6	1.4	-1.7	1.7	-1.7	1.9	1.7	-1.0	-1.7	1.6	-1.5	1.6	-1.7	1.4
Liver weight, left	2.3	3.6	5.5	1.2	1.3	2.1	-2.2	2.3	-2.2	1.8	-1.5	-1.8	-0.3	1.9	-2.2	2.2	-2.3	1.7	-2.2
Tibia length	2.3	6.4	8.4	1.8	2.2	2.5	-2.8	2.6	-2.4	2.9	-2.3	-2.8	0.1	2.9	-2.8	2.8	-2.6	2.8	-2.8
Light reinforcement 2	2.3	3.0	4.4	2.1	2.1	1.6	-1.7	1.7	-1.5	1.7	-2.1	-1.8	1.6	1.7	-1.6	1.6	-1.4	1.8	-1.7
Short access day 10 total infusions	2.3	2.6	4.7	-1.2	-1.7	-1.5	1.4	-1.6	1.4	-2.2	1.8	2.0	-0.4	-2.0	1.4	-1.4	1.4	-2.2	1.4
Times rat made contact with spout	2.2	2.6	3.0	1.7	1.7	1.6	-1.7	1.7	-1.7	1.4	-1.6	-1.6	0.9	1.6	-1.7	1.7	-1.6	1.5	-1.7
Condit. Reinf. active responses	2.2	3.1	4.8	-1.7	-1.9	-1.7	1.5	-1.6	1.7	-2.2	2.0	2.0	-0.9	-2.1	1.6	-1.6	1.5	-2.1	1.5
Delay discounting water rate 18 sec	2.1	2.7	4.7	-2.2	-2.2	-1.2	1.5	-1.5	1.5	-1.6	2.0	1.7	-1.9	-1.3	1.6	-1.5	1.3	-1.5	1.5
Time in familiar zone, hab. session 2	2.1	2.2	3.2	-1.8	-1.7	-1.5	1.4	-1.4	1.6	-1.3	1.7	1.5	-1.3	-1.3	1.5	-1.4	1.4	-1.2	1.4
Bone: tissue strength	2.1	2.0	3.2	1.8	1.8	1.4	-1.3	1.3	-1.4	1.4	-1.7	-1.5	1.4	1.4	-1.3	1.2	-1.2	1.3	-1.3
Rb content in liver	2.1	2.7	3.7	-1.7	-1.8	-1.7	1.5	-1.6	1.7	-1.7	1.9	1.7	-1.0	-1.8	1.5	-1.5	1.6	-1.8	1.5
Reaction time num false alarms	2.0	2.8	4.0	-1.0	-1.3	-1.8	2.0	-1.8	1.7	-1.8	1.3	1.7	0.2	-1.7	1.8	-1.9	1.8	-1.8	2.0
Short access total infusions	2.0	2.2	3.0	-1.1	-1.3	-1.6	1.5	-1.6	1.6	-1.7	1.4	1.7	0.1	-1.6	1.7	-1.5	1.6	-1.7	1.5
Locomotion distance, session 7	2.0	2.5	4.5	-1.8	-1.9	-1.5	1.2	-1.4	1.4	-2.1	2.1	1.9	-1.2	-1.6	1.2	-1.2	1.2	-1.8	1.2
Time in novel zone, hab. session 1	2.0	2.0	2.6	1.4	1.4	1.5	-1.6	1.5	-1.5	1.2	-1.3	-1.3	0.7	1.2	-1.6	1.6	-1.6	1.2	-1.6
Bone: endosteal perimeter	2.0	4.2	6.1	-1.9	-2.1	-2.2	1.8	-2.0	2.2	-2.5	2.2	2.3	-0.6	-2.2	2.0	-1.9	2.0	-2.4	1.8
Time to tail flick, vehicle, before self-admin	2.0	2.1	7.9	-2.4	-2.2	-0.7	1.0	-0.9	1.0	-1.0	1.9	1.2	-2.8	-1.0	1.0	-1.0	0.7	-1.0	1.0
Locomotion in novel chamber	2.0	2.5	4.3	0.2	-0.4	-1.6	1.7	-1.3	1.7	-1.7	0.7	1.5	2.0	-2.1	1.7	-1.7	2.0	-1.7	1.7
Lifetime Intake	1.9	2.1	3.0	-1.2	-1.4	-1.5	1.4	-1.6	1.5	-1.7	1.5	1.7	-0.2	-1.6	1.5	-1.4	1.5	-1.7	1.4
Bone: apparent density	1.9	3.2	7.8	-2.7	-2.4	-1.6	1.3	-1.4	1.5	-1.3	2.3	1.6	-2.8	-1.6	1.3	-1.3	1.2	-1.6	1.3
Bone: cortical thickness	1.9	2.3	2.7	1.5	1.6	1.6	-1.6	1.4	-1.5	1.4	-1.6	-1.6	0.9	1.5	-1.6	1.5	-1.5	1.5	-1.6
Reaction time num false alarms AUC	1.8	2.5	3.7	-0.9	-1.1	-1.7	1.9	-1.6	1.6	-1.7	1.2	1.6	0.2	-1.7	1.8	-1.8	1.7	-1.7	1.9
Pavlov. Cond. intertrial magazine entries	1.8	2.4	3.9	-1.9	-2.0	-1.3	1.5	-1.3	1.4	-1.4	1.7	1.6	-1.7	-1.3	1.5	-1.5	1.3	-1.5	1.5
Intermittent access total infusions	1.8	1.9	2.9	-1.2	-1.3	-1.4	1.3	-1.5	1.4	-1.7	1.4	1.6	-0.2	-1.6	1.4	-1.3	1.4	-1.7	1.3
Pavlov. Cond. intertrial magazine entries	1.8	2.1	2.6	-1.2	-1.3	-1.6	1.5	-1.6	1.6	-1.5	1.3	1.6	-0.1	-1.4	1.6	-1.6	1.5	-1.6	1.5
Time to tail flick, vehicle, after self-admin	1.8	2.0	2.6	-1.5	-1.4	-1.6	1.6	-1.5	1.6	-1.1	1.3	1.3	-0.9	-1.3	1.6	-1.6	1.4	-1.0	1.6
Water consumed over 24 hours	1.7	2.1	2.8	1.0	1.2	1.5	-1.5	1.5	-1.5	1.5	-1.3	-1.6	0.0	1.7	-1.5	1.6	-1.5	1.6	-1.5
Reaction time mean minus median AUC	1.7	2.2	3.1	-1.5	-1.4	-1.6	1.8	-1.3	1.7	-1.1	1.4	1.4	-0.8	-1.4	1.7	-1.8	1.6	-1.2	1.8
Total zone transitions, NPP test	1.7	2.5	3.0	-1.7	-1.7	-1.6	1.6	-1.7	1.4	-1.5	1.6	1.6	-1.1	-1.5	1.6	-1.6	1.5	-1.6	1.6
Ambulatory time after self-admin	1.7	1.9	3.2	0.8	0.9	1.8	-1.6	1.5	-1.6	1.3	-1.1	-1.3	-0.3	1.4	-1.6	1.5	-1.6	1.3	-1.6
Progressive ratio test 2 breakpoint	1.6	1.8	3.5	-0.8	-1.3	-1.1	1.1	-1.2	1.2	-1.9	1.3	1.8	0.1	-1.7	1.3	-1.2	1.1	-1.9	1.1
Bone: final force	1.6	2.6	3.3	1.5	1.6	1.7	-1.8	1.6	-1.6	1.5	-1.5	-1.8	0.6	1.7	-1.8	1.7	-1.5	1.6	-1.8
Ambulatory time before self-admin	1.6	1.7	3.5	1.9	1.7	1.2	-1.1	1.3	-1.2	1.0	-1.6	-1.1	1.8	0.9	-1.2	1.2	-1.0	1.0	-1.1
Length with tail	1.5	5.4	7.9	0.8	1.2	2.5	-2.6	2.5	-2.4	2.6	-1.5	-2.4	-1.5	2.6	-2.6	2.5	-2.8	2.8	-2.6
Intermittent access intake escalation	1.5	1.5	2.4	-0.3	-0.5	-1.3	1.2	-1.1	1.4	-1.5	0.8	1.3	1.2	-1.5	1.3	-1.2	1.5	-1.4	1.2
Progressive ratio test 2 active lever presses	1.5	1.6	3.2	-0.8	-1.3	-1.1	1.1	-1.2	1.2	-1.8	1.3	1.7	-0.0	-1.6	1.3	-1.2	1.1	-1.8	1.1
Short access day 1 total infusions	1.5	1.6	2.2	-0.6	-0.8	-1.4	1.4	-1.3	1.4	-1.5	1.0	1.4	0.6	-1.3	1.5	-1.3	1.5	-1.4	1.4
Compulsive drug intake	1.5	1.5	2.8	0.5	0.9	1.1	-1.2	1.3	-1.2	1.7	-1.1	-1.5	-0.5	1.5	-1.2	1.2	-1.2	1.6	-1.2
Reaction time false alarm rate	1.4	2.0	3.0	-0.9	-1.0	-1.5	1.7	-1.6	1.5	-1.4	1.0	1.4	0.2	-1.4	1.7	-1.6	1.6	-1.4	1.7
Social response proportion	1.4	1.5	3.5	-0.2	0.1	1.4	-1.2	1.3	-1.3	1.5	-0.4	-1.2	-1.9	1.4	-1.2	1.2	-1.4	1.4	-1.2
Pavlov. Cond. magazine entry latency	1.4	1.6	2.2	1.5	1.5	1.2	-1.4	1.3	-1.3	1.0	-1.3	-1.2	1.1	1.1	-1.4	1.3	-1.3	1.1	-1.4
Bone: maximum force	1.4	2.3	2.7	1.6	1.6	1.6	-1.6	1.5	-1.5	1.5	-1.6	-1.6	0.9	1.6	-1.7	1.5	-1.4	1.5	-1.6
Time in open arm before self-admin	1.4	1.5	8.7	2.2	1.8	0.7	-0.8	0.9	-0.8	0.2	-1.5	-0.5	2.9	-0.2	-0.9	0.9	-0.7	0.2	-0.8
Seeking ratio, punishment vs. effort	1.4	1.7	2.3	1.2	1.3	1.5	-1.3	1.4	-1.4	1.2	-1.3	-1.2	0.8	1.4	-1.3	1.4	-1.4	1.3	-1.3
Cu content in liver	1.4	1.6	2.2	1.5	1.3	1.4	-1.3	1.4	-1.4	1.0	-1.4	-1.2	1.0	1.2	-1.3	1.2	-1.3	1.2	-1.3
Conditioned reinforcement - inactives	1.3	1.5	2.3	-1.1	-1.3	-1.0	1.2	-1.3	1.1	-1.5	1.3	1.4	-0.5	-1.4	1.0	-1.2	1.0	-1.5	1.2
Progressive ratio test 2 inactive lever presses	1.3	1.6	3.0	-0.6	-1.0	-1.1	1.1	-1.4	1.1	-1.7	1.1	1.6	0.5	-1.6	1.2	-1.2	1.1	-1.7	1.1
Locomotion velocity, session 7	1.3	1.4	2.4	-1.3	-1.4	-0.9	1.0	-1.0	0.9	-1.6	1.5	1.3	-0.8	-1.3	1.0	-1.0	0.9	-1.4	1.0
Pavlov. Cond. latency score	1.3	1.7	2.6	0.6	0.8	1.4	-1.4	1.3	-1.4	1.5	-1.0	-1.4	-0.6	1.6	-1.4	1.4	-1.4	1.6	-1.4
Run reversals in cocaine runway, males	1.3	1.3	2.0	-0.9	-1.0	-1.2	1.2	-1.1	1.2	-1.3	1.0	1.3	0.1	-1.4	1.2	-1.2	1.2	-1.4	1.2
Parametrial fat weight	1.2	2.4	21.6	-2.8	-2.2	0.0	-0.1	0.1	-0.1	0.2	1.9	0.3	-4.6	0.0	-0.2	0.0	-0.6	0.2	-0.1
Bone: final moment	1.2	2.0	2.4	1.4	1.4	1.4	-1.5	1.4	-1.4	1.3	-1.4	-1.5	0.7	1.5	-1.6	1.5	-1.3	1.4	-1.5
Delay discount exponential model param	1.2	1.3	2.3	-1.5	-1.3	-1.3	1.2	-1.3	1.2	-0.6	1.2	0.8	-1.4	-0.7	1.1	-1.2	1.1	-0.7	1.2
Progressive ratio	1.2	1.3	2.8	-1.0	-0.9	-1.3	1.3	-1.7	1.4	-0.7	0.8	0.9	-0.4	-1.1	1.3	-1.3	1.4	-0.8	1.3
Delay discounting water rate 0 sec	1.1	1.8	2.8	-1.1	-1.2	-1.2	1.6	-1.7	1.3	-1.3	1.1	1.3	-0.3	-1.2	1.5	-1.6	1.5	-1.3	1.6
Pavlov. Cond. magazine entry number	1.1	1.3	2.2	-1.5	-1.4	-1.0	1.2	-1.1	1.0	-0.8	1.2	1.1	-1.4	-1.0	1.2	-1.1	1.0	-1.0	1.2
Locomotion distance, session 2	1.1	1.5	2.9	-1.7	-1.6	-0.9	1.2	-1.1	0.9	-1.0	1.4	1.1	-1.7	-1.1	1.2	-1.1	1.0	-1.1	1.2
Extinction: sum of active levers before priming	1.1	1.2	2.5	-1.6	-1.6	-0.7	0.7	-0.7	0.8	-1.1	1.6	1.2	-1.6	-0.9	0.7	-0.8	0.5	-1.0	0.7
BMI with tail	1.0	3.1	4.9	-2.1	-2.2	-1.6	1.5	-1.4	1.6	-2.0	2.2	1.9	-1.7	-1.9	1.4	-1.5	1.4	-1.9	1.5
Epididymis fat weight	1.0	2.3	8.9	-2.5	-2.4	-0.8	0.5	-0.4	0.8	-1.5	2.3	1.5	-3.0	-1.4	0.6	-0.7	0.2	-1.4	0.5
Glucose	1.0	1.5	7.2	2.1	1.8	0.6	-1.0	1.0	-0.7	0.5	-1.4	-0.8	2.7	0.5	-1.0	0.9	-0.7	0.5	-1.0
Saline control response	1.0	1.3	1.8	-1.2	-1.2	-1.3	1.0	-1.3	1.2	-1.2	1.3	1.2	-0.7	-1.3	1.0	-0.9	1.2	-1.3	1.0
Cocaine induced anxiety	1.0	1.1	2.0	-0.4	-0.7	-1.4	1.2	-1.1	1.2	-1.1	0.8	1.1	0.4	-1.1	1.2	-1.2	1.2	-1.1	1.2
Progressive ratio test 1 breakpoint	1.0	1.0	1.9	-1.1	-1.3	-0.8	0.5	-0.9	0.7	-1.4	1.3	1.3	-0.7	-1.2	0.8	-0.5	0.6	-1.4	0.5
Locomotion velocity, hab. session 1	1.0	1.4	2.1	-1.3	-1.3	-1.2	1.3	-1.5	1.2	-1.0	1.1	1.1	-0.9	-0.9	1.2	-1.2	1.3	-0.9	1.3
Bone: maximum moment	1.0	1.7	2.1	1.4	1.4	1.3	-1.3	1.2	-1.3	1.2	-1.4	-1.4	0.9	1.3	-1.3	1.2	-1.2	1.2	-1.3
Area under the delay curve	1.0	1.0	2.2	1.4	1.2	1.1	-1.0	1.2	-1.0	0.5	-1.1	-0.7	1.5	0.5	-0.9	1.0	-0.9	0.6	-1.0
Delay discount hyperbolic model param	1.0	1.1	2.0	-1.4	-1.2	-1.1	1.0	-1.2	1.0	-0.6	1.1	0.7	-1.4	-0.6	1.0	-1.0	1.0	-0.7	1.0
Latency to leave start box in cocaine runway, F	1.0	1.1	2.9	0.6	1.0	1.0	-0.8	0.7	-0.8	1.7	-1.2	-1.3	-0.2	1.5	-0.9	0.8	-0.8	1.6	-0.8
Cd content in liver	1.0	1.1	1.7	-1.3	-1.3	-1.1	0.9	-1.0	1.0	-1.0	1.3	1.2	-0.9	-1.0	0.9	-0.9	0.8	-1.1	0.9
Se content in liver	1.0	1.2	1.8	1.3	1.3	1.2	-1.0	0.9	-1.1	1.1	-1.3	-1.1	1.1	1.1	-1.0	1.0	-0.9	1.2	-1.0
Locomotor testing rearing	0.9	1.4	2.5	-1.0	-1.2	-1.3	1.1	-0.9	1.2	-1.5	1.3	1.3	-0.4	-1.6	1.0	-1.1	1.1	-1.4	1.1
Condit. Reinf. lever presses	0.9	1.2	1.8	-0.5	-0.6	-1.3	1.1	-1.2	1.3	-1.2	0.8	1.1	0.6	-1.2	1.2	-1.2	1.3	-1.2	1.1
Bone: trabecular tissue density	0.9	1.3	3.8	1.7	1.6	0.9	-0.8	0.8	-0.7	0.9	-1.5	-1.0	1.9	1.0	-0.8	0.8	-0.6	1.1	-0.8
Delay disc. indifference point, 4s delay	0.9	0.9	1.5	1.1	1.0	1.1	-1.1	1.2	-1.1	0.5	-0.9	-0.7	1.0	0.6	-1.0	1.1	-1.1	0.5	-1.1
Weight adjusted by age	0.9	1.0	1.8	-1.3	-1.2	-0.7	0.6	-0.9	0.6	-1.3	1.3	1.2	-0.8	-1.3	0.6	-0.7	0.5	-1.3	0.6
Zn content in liver	0.9	0.9	1.2	-0.9	-1.0	-1.0	1.1	-0.9	0.9	-1.1	1.0	1.0	-0.5	-1.0	1.1	-1.1	0.9	-0.9	1.1
Liver weight, right	0.8	1.3	2.3	0.3	0.5	1.2	-1.5	1.3	-1.2	1.1	-0.5	-1.0	-0.7	1.1	-1.5	1.5	-1.4	0.9	-1.5
Incentive Sensitization - Responses	0.8	0.8	2.1	-0.3	-0.8	-0.5	0.8	-0.7	0.6	-1.4	0.8	1.3	0.3	-1.2	0.8	-0.9	0.6	-1.4	0.8
Total locomotion distance, hab. session 1	0.8	1.1	1.5	-1.2	-1.2	-1.1	1.1	-1.2	1.1	-1.0	1.1	1.1	-0.8	-0.9	1.1	-1.1	1.0	-0.9	1.1
Total locomotion distance, NPP test	0.8	1.2	1.6	-0.9	-1.0	-1.1	1.3	-1.2	1.0	-1.2	0.9	1.2	-0.2	-1.0	1.2	-1.2	1.2	-1.1	1.3
Locomotion velocity, NPP test	0.8	1.1	1.7	-0.6	-0.7	-1.1	1.3	-1.3	1.1	-1.1	0.7	1.1	0.3	-1.0	1.2	-1.3	1.3	-1.1	1.3
Pavlov. Cond. lever latency	0.8	1.0	1.5	-0.7	-0.8	-1.1	1.1	-1.1	1.1	-1.0	0.9	1.0	-0.1	-1.2	1.1	-1.1	1.0	-1.1	1.1
Pavlov. Cond. index score	0.8	1.1	1.8	0.3	0.6	1.1	-1.0	1.0	-1.1	1.2	-0.8	-1.1	-0.7	1.3	-1.1	1.0	-1.1	1.3	-1.0
Bone: maximum diameter	0.8	1.5	2.7	-0.7	-0.9	-1.4	1.1	-1.4	1.4	-1.6	1.1	1.4	0.4	-1.6	1.1	-1.1	1.3	-1.6	1.1
Bone: minimum diameter	0.8	1.5	2.2	1.5	1.3	1.2	-1.4	1.3	-1.2	0.7	-1.2	-0.9	1.3	1.0	-1.3	1.3	-1.3	0.8	-1.4
Active lever presses in extinction session 6	0.8	0.7	1.7	-1.2	-1.2	-0.7	0.5	-0.5	0.6	-0.8	1.3	0.8	-1.3	-0.9	0.6	-0.6	0.5	-0.8	0.5
Fe content in liver	0.8	1.0	1.4	0.5	0.7	1.1	-1.1	1.1	-1.1	1.1	-0.8	-1.0	-0.4	1.1	-1.1	1.1	-1.2	1.1	-1.1
Mean time between licks in bursts	0.7	1.0	1.6	0.5	0.6	1.3	-1.1	1.1	-1.2	1.1	-0.8	-1.0	-0.4	1.1	-1.0	0.9	-1.2	1.1	-1.1
Mean num. licks in bursts	0.7	0.9	1.6	0.7	0.7	1.1	-1.1	1.3	-1.1	0.9	-0.8	-1.0	-0.1	0.9	-1.1	0.9	-1.1	0.9	-1.1
Indifference point AUC	0.7	0.8	1.3	-0.2	-0.4	-1.1	0.9	-0.9	0.9	-1.1	0.6	1.0	0.8	-1.0	0.9	-0.9	0.9	-1.1	0.9
Intermittent access intake escalation 2	0.7	0.7	2.2	0.2	0.1	-1.0	0.9	-0.7	1.0	-0.7	0.1	0.6	1.5	-1.0	0.9	-0.9	1.2	-0.6	0.9
Intermitt. access day 1 inactive lever presses	0.7	0.7	4.7	1.5	1.2	0.5	-0.5	0.7	-0.5	-0.0	-1.0	-0.3	2.2	0.1	-0.6	0.5	-0.4	0.0	-0.5
Intermittent access day 1 total infusions	0.7	0.7	1.2	-0.9	-1.1	-0.6	0.7	-0.9	0.7	-1.1	1.1	1.0	-0.7	-1.0	0.7	-0.7	0.6	-1.1	0.7
Progressive ratio test 1 active lever presses	0.7	0.7	1.7	-0.8	-1.0	-0.7	0.4	-0.8	0.6	-1.3	1.1	1.2	-0.3	-1.2	0.6	-0.4	0.5	-1.3	0.4
Incentive salience index mean	0.7	0.8	1.6	0.6	0.7	1.1	-0.8	0.7	-0.9	1.0	-1.0	-1.0	-0.1	1.2	-0.8	0.8	-0.7	1.1	-0.8
Total zone transitions, hab. session 2	0.7	0.9	1.8	-1.3	-1.2	-0.9	0.9	-0.9	0.8	-0.7	1.0	0.8	-1.3	-0.7	0.9	-0.9	0.7	-0.7	0.9
Pavlov. Cond. lever contacts	0.7	0.8	1.3	0.6	0.7	1.0	-1.0	0.9	-1.0	1.0	-0.8	-1.0	-0.0	1.1	-1.0	1.0	-0.9	1.0	-1.0
Delay disc. indifference point, 2s delay	0.7	0.8	1.7	1.2	1.1	0.8	-0.8	0.9	-0.8	0.6	-1.0	-0.7	1.3	0.6	-0.8	0.8	-0.8	0.7	-0.8
Delay disc. indifference point, 8s delay	0.7	0.7	1.2	1.1	0.9	0.9	-0.8	1.0	-0.8	0.4	-0.9	-0.6	1.0	0.5	-0.8	0.8	-0.8	0.6	-0.8
Change in fecal boli incidents, locomotor task	0.7	0.7	1.0	0.9	0.8	0.7	-1.0	0.8	-0.7	0.7	-0.9	-0.8	0.6	0.6	-0.8	1.0	-0.8	0.8	-1.0
Social time	0.6	0.8	6.8	-1.6	-1.1	-0.2	0.4	-0.3	0.3	0.6	0.8	-0.2	-2.6	0.2	0.3	-0.3	0.1	0.6	0.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	-0.9	-1.0	-0.8	0.6	-0.6	0.7	-1.2	1.1	1.1	-0.6	-1.1	0.6	-0.7	0.6	-1.1	0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.6	-0.2	-0.7	-0.4	0.7	-0.5	0.6	-1.2	0.6	1.1	0.3	-1.1	0.7	-0.8	0.5	-1.3	0.7
Short access day 10 total inactive lever presses	0.6	0.7	1.0	0.9	0.8	1.0	-0.9	0.9	-0.9	0.7	-0.8	-0.8	0.4	0.8	-1.0	0.9	-0.9	0.8	-0.9
Locomotion distance, session 8	0.6	0.9	4.6	-1.7	-1.4	-0.4	0.5	-0.6	0.3	-0.4	1.2	0.7	-2.1	-0.5	0.4	-0.4	0.3	-0.6	0.5
Condit. Reinf. lever presses	0.6	0.8	1.5	-0.0	0.3	1.1	-0.9	0.8	-1.0	1.1	-0.6	-1.0	-1.1	1.2	-0.9	0.9	-0.9	1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.4	0.2	0.4	0.9	-0.8	0.8	-0.9	1.1	-0.6	-0.9	-0.7	1.2	-0.8	0.8	-0.9	1.2	-0.8
Bone: cortical area	0.6	0.8	4.0	1.5	1.3	0.6	-0.8	0.5	-0.6	0.2	-1.1	-0.5	2.0	0.4	-0.8	0.7	-0.5	0.2	-0.8
Distance traveled before self-admin	0.6	0.6	3.0	1.4	1.2	0.6	-0.5	0.5	-0.6	0.3	-1.1	-0.5	1.7	0.3	-0.5	0.5	-0.3	0.4	-0.5
Diff in mean of infusions in LGA sessions	0.6	0.6	1.1	0.1	0.3	0.9	-1.0	0.9	-0.9	0.8	-0.3	-0.7	-0.7	0.6	-0.9	0.9	-1.0	0.8	-1.0
Total heroin consumption	0.6	0.7	6.2	-1.6	-1.3	-0.0	-0.0	-0.2	-0.1	-0.1	1.1	0.3	-2.5	-0.2	-0.0	0.0	-0.3	-0.2	-0.0
Vertical activity count, locomotor time 1	0.6	0.7	1.0	-0.9	-1.0	-0.7	0.9	-0.7	0.7	-0.9	1.0	0.7	-0.9	-0.6	0.8	-0.8	0.7	-0.8	0.9
Soleus weight	0.5	1.6	13.3	-2.3	-1.9	0.0	-0.1	-0.1	-0.1	-0.1	1.5	0.4	-3.6	-0.2	-0.1	0.0	-0.4	-0.3	-0.1
Delay discounting water rate 24 sec	0.5	0.6	1.0	-0.8	-0.8	-0.5	0.9	-0.9	0.9	-0.7	0.8	0.8	-0.4	-0.6	0.9	-1.0	1.0	-0.6	0.9
Pavlov. Cond. response bias	0.5	0.7	2.2	1.3	1.1	0.6	-0.9	0.7	-0.6	0.3	-0.9	-0.6	1.5	0.5	-0.9	0.8	-0.6	0.5	-0.9
Intermittent access day 15 total locomotion	0.5	0.5	1.1	-0.0	-0.3	-0.5	0.6	-0.8	0.6	-1.0	0.5	0.8	0.8	-1.0	0.6	-0.6	0.7	-1.0	0.6
Locomotion velocity, session 1	0.5	0.5	5.1	-1.3	-1.0	0.1	0.0	0.0	-0.2	0.1	0.7	0.1	-2.3	0.3	0.0	-0.0	-0.3	0.1	0.0
Locomotion distance, session 1	0.5	0.7	1.2	-1.1	-1.0	-0.6	0.9	-0.9	0.5	-0.5	0.7	0.7	-1.1	-0.6	0.8	-0.8	0.8	-0.6	0.9
Stereotopy head waving bouts, day 3	0.5	0.6	1.2	0.4	0.7	0.9	-0.8	0.7	-0.7	1.1	-0.9	-1.0	-0.3	0.9	-0.6	0.7	-0.7	1.1	-0.8
Stereotopy head waving duration, day 7	0.5	0.6	2.7	-1.3	-1.0	-0.6	0.6	-0.7	0.6	-0.0	0.7	0.4	-1.6	-0.5	0.7	-0.6	0.5	-0.4	0.6
Condit. Reinf. active minus inactive responses	0.5	0.5	1.0	0.7	0.7	0.9	-0.7	0.6	-0.8	0.8	-0.9	-0.8	0.2	1.0	-0.7	0.7	-0.6	0.9	-0.7
Pavlov. Cond. change in total contacts	0.5	0.6	1.0	0.9	0.9	0.7	-0.7	0.6	-0.7	0.7	-1.0	-0.8	0.7	0.9	-0.6	0.7	-0.5	0.8	-0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	0.1	0.1	-1.0	0.8	-0.9	0.9	-0.2	-0.1	0.2	0.9	-0.5	0.8	-0.9	1.0	-0.2	0.8
Delta time to tail flick, test, before/after SA	0.5	0.4	2.0	-0.3	-0.5	-0.4	0.3	-0.3	0.3	-1.1	0.6	0.8	0.2	-1.4	0.3	-0.3	0.3	-1.2	0.3
Run reversals in cocaine runway, females	0.5	0.5	0.9	-0.3	-0.3	-0.9	0.9	-0.5	0.9	-0.5	0.3	0.6	0.4	-0.7	0.9	-0.9	0.9	-0.5	0.9
Delay discounting total patch changes 12 sec	0.4	0.6	1.1	1.0	1.0	0.5	-0.5	0.7	-0.7	0.9	-1.0	-0.8	0.8	0.8	-0.5	0.5	-0.6	0.8	-0.5
Reaction time premature initiations	0.4	0.6	1.1	-1.0	-1.0	-0.8	0.8	-0.5	0.6	-0.6	0.8	0.7	-1.0	-0.6	0.8	-0.8	0.6	-0.6	0.8
Cocaine response before conditioning	0.4	0.5	1.7	-1.1	-1.1	-0.4	0.6	-0.5	0.5	-0.6	0.9	0.6	-1.3	-0.4	0.5	-0.6	0.4	-0.4	0.6
Post-drug Anxiety	0.4	0.5	0.9	-0.5	-0.6	-0.9	0.8	-0.6	0.8	-0.5	0.6	0.6	-0.3	-0.5	0.8	-0.8	0.7	-0.5	0.8
Short access day 1 locomotion	0.4	0.4	0.9	-0.2	-0.3	-0.5	0.6	-0.7	0.5	-1.0	0.4	0.7	0.7	-0.7	0.6	-0.5	0.6	-0.9	0.6
Context. condit. distance diff. score	0.4	0.5	1.9	-1.2	-1.0	-0.4	0.3	-0.6	0.4	-0.4	1.0	0.6	-1.4	-0.4	0.3	-0.3	0.3	-0.5	0.3
Locomotion velocity, session 8	0.4	0.5	0.9	-1.0	-0.8	-0.7	0.8	-0.8	0.7	-0.4	0.7	0.5	-0.9	-0.5	0.8	-0.7	0.7	-0.6	0.8
Pavlov. Cond. magazine entry latency	0.4	0.6	1.0	0.1	0.3	0.8	-0.7	0.8	-0.8	0.9	-0.5	-0.8	-0.8	0.9	-0.8	0.7	-0.9	1.0	-0.7
Bone: periosteal perimeter	0.4	0.7	1.5	-0.2	-0.5	-0.9	0.6	-0.8	0.9	-1.2	0.7	1.0	0.7	-1.1	0.6	-0.6	0.8	-1.2	0.6
Time in closed arm before self-admin	0.4	0.5	3.7	-0.9	-0.5	0.4	-0.3	0.2	-0.2	0.8	0.1	-0.5	-1.9	0.9	-0.2	0.2	-0.4	0.8	-0.3
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.8	-0.8	-0.9	0.4	-0.3	0.3	-0.3	-0.5	0.8	0.4	-1.4	-0.5	-0.3	0.3	-0.4	-0.5	-0.3
Time to tail flick, test, before self-admin	0.4	0.4	1.6	-0.7	-0.3	-0.2	0.4	-0.5	0.5	0.9	0.0	-0.4	-1.2	0.8	0.5	-0.5	0.4	0.8	0.4
Delay disc. indifference point, 16s delay	0.4	0.4	1.7	1.0	0.5	0.6	-0.5	0.7	-0.5	-0.5	-0.3	0.2	1.3	-0.5	-0.4	0.5	-0.4	-0.6	-0.5
Rest time, locomotor task time 1	0.4	0.4	0.7	-0.3	-0.4	-0.8	0.7	-0.9	0.9	-0.4	0.4	0.6	0.1	-0.8	0.8	-0.7	0.8	-0.4	0.7
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.1	1.0	0.9	0.6	-0.6	0.8	-0.6	0.3	-0.7	-0.5	1.0	0.5	-0.6	0.6	-0.5	0.4	-0.6
Distance moved, locomotor task time 2	0.4	0.4	0.8	-0.5	-0.4	-0.8	0.8	-0.7	0.8	-0.6	0.5	0.6	0.3	-0.4	0.9	-0.7	0.9	-0.5	0.8
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	-0.5	-0.6	-0.9	0.8	-0.9	0.9	-0.5	0.6	0.5	-0.3	-0.5	0.8	-0.8	0.9	-0.4	0.8
Latency to leave start box in cocaine runway	0.4	0.4	1.0	0.4	0.7	0.6	-0.5	0.5	-0.5	1.0	-0.7	-0.8	0.1	0.8	-0.6	0.6	-0.5	1.0	-0.5
Sr content in liver	0.4	0.4	1.0	-0.9	-0.8	-0.4	0.7	-0.4	0.4	-0.3	0.6	0.5	-1.0	-0.4	0.7	-0.7	0.3	-0.4	0.7
Std. dev. time between licks in bursts	0.3	0.3	0.6	-0.8	-0.7	-0.5	0.6	-0.6	0.5	-0.4	0.6	0.5	-0.6	-0.6	0.6	-0.7	0.5	-0.5	0.6
Delay discounting total patch changes 18 sec	0.3	0.5	0.9	0.9	0.9	0.3	-0.8	0.6	-0.5	0.4	-0.6	-0.6	1.0	0.4	-0.8	0.7	-0.5	0.4	-0.8
Delay discounting total patch changes 6 sec	0.3	0.4	0.8	-0.1	-0.2	-0.9	0.8	-0.7	0.7	-0.7	0.3	0.5	0.5	-0.6	0.8	-0.8	0.8	-0.6	0.8
Reaction time premature initiation rate	0.3	0.4	0.8	-0.9	-0.8	-0.7	0.7	-0.5	0.6	-0.4	0.7	0.6	-0.9	-0.5	0.7	-0.7	0.5	-0.4	0.7
Social responses	0.3	0.4	3.4	-0.9	-0.7	0.4	-0.2	0.2	-0.3	0.4	0.5	-0.2	-1.9	0.3	-0.2	0.2	-0.4	0.3	-0.2
Cocaine response after cond. corrected	0.3	0.3	0.7	0.2	0.3	0.6	-0.6	0.6	-0.7	0.7	-0.4	-0.6	-0.3	0.4	-0.6	0.8	-0.7	0.4	-0.6
Pavlov. Cond. change in total contacts	0.3	0.4	1.5	1.0	0.9	0.4	-0.6	0.4	-0.4	0.2	-0.8	-0.5	1.2	0.4	-0.6	0.5	-0.4	0.4	-0.6
Pavlov. Cond. index score	0.3	0.4	3.1	1.1	0.9	0.1	-0.4	0.2	-0.1	-0.1	-0.6	-0.2	1.7	-0.0	-0.4	0.3	-0.1	0.1	-0.4
Pavlov. Cond. latency score	0.3	0.4	3.5	1.2	1.0	0.1	-0.3	0.1	-0.1	-0.1	-0.7	-0.2	1.9	-0.0	-0.3	0.3	-0.0	0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	2.7	1.0	0.9	0.0	-0.4	0.2	-0.1	-0.1	-0.5	-0.2	1.7	-0.1	-0.3	0.3	-0.0	0.0	-0.4
Short access total locomotion	0.3	0.3	0.6	-0.1	-0.2	-0.3	0.5	-0.7	0.4	-0.8	0.3	0.6	0.7	-0.5	0.4	-0.4	0.5	-0.7	0.5
Number of responses in last shaping day	0.3	0.3	1.9	0.6	0.2	-0.2	0.1	-0.6	0.2	-0.8	0.0	0.4	1.4	-0.6	0.2	-0.1	0.4	-0.7	0.1
Stereotopy head waving bouts, day 7	0.3	0.4	2.0	-1.1	-0.8	-0.4	0.5	-0.5	0.4	0.1	0.4	0.2	-1.4	-0.3	0.5	-0.5	0.4	-0.2	0.5
Degree of sensitization distance	0.3	0.3	1.0	-0.9	-0.9	-0.3	-0.0	-0.1	0.2	-0.8	1.0	0.7	-1.0	-0.4	0.0	-0.0	-0.1	-0.6	-0.0
Degree of sensitization stereotypy	0.3	0.3	2.6	-1.0	-0.7	-0.2	0.2	-0.2	0.1	0.3	0.5	0.1	-1.6	-0.1	0.2	-0.2	0.1	-0.1	0.2
Novel to familiar place preference ratio	0.3	0.4	0.9	-0.0	-0.3	-0.6	0.5	-0.4	0.6	-0.8	0.5	0.6	0.6	-0.9	0.5	-0.5	0.7	-0.7	0.5
Pavlov. Cond. response bias	0.3	0.3	0.7	0.1	0.2	0.6	-0.6	0.5	-0.6	0.7	-0.4	-0.6	-0.6	0.8	-0.6	0.5	-0.6	0.8	-0.6
Bone: endosteal estimation	0.3	0.6	1.1	-0.7	-0.8	-0.8	0.6	-0.7	0.8	-1.1	0.9	0.9	-0.2	-0.8	0.7	-0.7	0.7	-1.0	0.6
Bone: marrow area	0.3	0.5	1.0	-0.6	-0.8	-0.7	0.6	-0.6	0.8	-1.0	0.8	0.9	-0.2	-0.8	0.7	-0.7	0.6	-0.9	0.6
Bone: stiffness	0.3	0.5	1.7	-0.4	-0.1	0.8	-0.8	0.7	-0.7	0.6	0.0	-0.6	-1.3	0.8	-0.8	0.7	-0.8	0.7	-0.8
Breakpoint value in progressive ratio session	0.3	0.3	1.0	-0.3	-0.3	0.6	-0.7	0.7	-0.6	0.2	0.2	-0.2	-1.0	0.2	-0.6	0.6	-0.8	0.1	-0.7
Delta distance traveled before/after self-admin	0.3	0.3	2.7	-0.9	-0.7	0.3	-0.3	0.3	-0.2	0.1	0.5	-0.1	-1.6	0.2	-0.2	0.2	-0.4	0.1	-0.3
Time in open arm after self-admin	0.3	0.3	1.9	0.8	0.4	0.1	-0.3	0.4	-0.3	-0.7	-0.1	0.2	1.4	-0.7	-0.4	0.4	-0.2	-0.8	-0.3
Rest time, locomotor task time 2	0.3	0.3	0.8	-0.3	-0.6	-0.6	0.6	-0.6	0.6	-0.6	0.6	0.8	-0.1	-0.9	0.5	-0.5	0.5	-0.6	0.6
Body weight	0.2	0.9	6.9	-1.3	-1.0	0.5	-0.8	0.7	-0.5	0.2	0.8	-0.1	-2.6	0.3	-0.8	0.7	-1.0	0.4	-0.8
Length without tail	0.2	0.4	3.6	-0.9	-0.6	0.3	-0.3	0.2	-0.3	0.6	0.4	-0.2	-1.9	0.5	-0.3	0.2	-0.5	0.7	-0.3
Indifference point function ln k	0.2	0.2	1.7	-0.9	-0.6	-0.2	0.3	-0.3	0.2	0.1	0.5	0.1	-1.3	-0.1	0.2	-0.4	0.2	0.0	0.3
Indifference point function log k	0.2	0.2	1.7	-0.9	-0.6	-0.2	0.3	-0.3	0.2	0.1	0.5	0.1	-1.3	-0.1	0.2	-0.4	0.2	0.0	0.3
Delay discounting total patch changes 0 sec	0.2	0.3	0.5	-0.6	-0.6	-0.6	0.6	-0.7	0.5	-0.3	0.5	0.4	-0.6	-0.3	0.6	-0.6	0.6	-0.3	0.6
Delay discounting total patch changes 24 sec	0.2	0.2	1.3	0.9	0.7	0.2	-0.2	0.3	-0.4	0.1	-0.6	-0.3	1.1	0.2	-0.2	0.2	-0.2	0.2	-0.2
Reaction time mean minus median	0.2	0.3	0.7	-0.2	-0.2	-0.6	0.8	-0.3	0.7	-0.2	0.2	0.4	0.2	-0.3	0.8	-0.8	0.7	-0.3	0.8
Median of all reaction times	0.2	0.3	0.5	0.7	0.7	0.6	-0.5	0.6	-0.4	0.6	-0.6	-0.5	0.6	0.7	-0.5	0.5	-0.5	0.4	-0.5
Std. dev. reaction times	0.2	0.2	0.7	-0.2	-0.1	-0.5	0.8	-0.3	0.6	-0.0	0.0	0.2	0.1	-0.2	0.7	-0.8	0.6	-0.1	0.8
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.1	0.1	0.5	-0.5	0.6	-0.6	0.6	-0.1	-0.4	-0.7	0.3	-0.5	0.7	-0.7	0.4	-0.5
Pavlov. Cond. lever latency	0.2	0.3	2.5	-0.8	-0.6	0.3	0.1	0.1	-0.3	0.4	0.3	-0.2	-1.6	0.4	0.1	-0.1	-0.3	0.3	0.1
Pavlov. Cond. lever contacts	0.2	0.3	1.4	0.9	0.8	0.2	-0.5	0.4	-0.2	0.1	-0.6	-0.3	1.2	0.2	-0.5	0.5	-0.3	0.2	-0.5
Intermitt. access day 15 inactive lever presses	0.2	0.2	1.3	0.3	0.2	-0.3	0.3	-0.5	0.2	-0.6	-0.1	0.5	1.1	-0.7	0.2	-0.3	0.2	-0.6	0.3
Intermittent access day 1 locomotion	0.2	0.3	0.5	0.6	0.5	0.7	-0.6	0.2	-0.6	0.0	-0.4	-0.2	0.6	0.4	-0.6	0.6	-0.6	0.1	-0.6
Baseline Anxiety	0.2	0.3	0.7	0.2	0.3	0.6	-0.6	0.8	-0.6	0.5	-0.3	-0.5	-0.2	0.4	-0.6	0.6	-0.6	0.5	-0.6
Progressive ratio test 1 inactive lever presses	0.2	0.2	1.0	0.5	0.2	-0.1	0.2	-0.2	0.1	-0.5	-0.1	0.4	1.0	-0.6	0.1	-0.2	0.1	-0.6	0.2
Total sessions with >9 infusions	0.2	0.2	0.4	-0.6	-0.5	-0.3	0.2	-0.5	0.4	-0.6	0.6	0.5	-0.3	-0.4	0.4	-0.2	0.4	-0.5	0.2
Locomotion velocity, session 2	0.2	0.3	1.5	-0.9	-0.8	-0.2	0.5	-0.3	0.3	-0.1	0.6	0.4	-1.2	-0.3	0.5	-0.5	0.2	-0.2	0.5
Locomotion distance, session 3	0.2	0.2	0.5	-0.3	-0.3	-0.5	0.6	-0.7	0.4	-0.4	0.3	0.4	0.1	-0.4	0.5	-0.6	0.7	-0.4	0.6
Condit. Reinf. active responses	0.2	0.3	0.4	-0.7	-0.6	-0.4	0.5	-0.6	0.4	-0.4	0.4	0.5	-0.6	-0.3	0.5	-0.6	0.5	-0.4	0.5
Bone: cortical apparent density	0.2	0.3	0.5	0.1	-0.1	-0.3	0.6	-0.5	0.4	-0.5	0.1	0.5	0.7	-0.5	0.6	-0.7	0.5	-0.6	0.6
Bone: cortical tissue density	0.2	0.3	0.5	-0.0	-0.2	-0.3	0.7	-0.5	0.4	-0.5	0.2	0.5	0.5	-0.5	0.7	-0.7	0.5	-0.6	0.7
Bone: elastic displacement	0.2	0.2	0.7	0.3	0.2	-0.4	0.4	-0.6	0.3	-0.3	-0.2	0.2	0.8	-0.4	0.3	-0.4	0.5	-0.4	0.4
Bone: trabecular spacing	0.2	0.2	1.3	0.9	0.6	0.4	-0.4	0.3	-0.3	-0.1	-0.5	-0.2	1.1	0.2	-0.3	0.4	-0.2	0.2	-0.4
Distance traveled after self-admin	0.2	0.2	0.6	0.4	0.3	0.8	-0.5	0.5	-0.6	0.1	-0.4	-0.3	0.2	0.1	-0.5	0.5	-0.5	0.1	-0.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.0	-0.1	-0.7	0.5	-0.5	0.5	-0.4	0.1	0.4	0.6	-0.6	0.5	-0.5	0.4	-0.4	0.5
Delta time in open arm before/after self-admin	0.2	0.2	1.1	-0.6	-0.6	0.1	-0.2	0.2	-0.2	-0.3	0.6	0.1	-1.0	0.0	-0.2	0.2	-0.2	-0.3	-0.2
Delta ambulatory time before/after self-admin	0.2	0.3	2.3	-0.8	-0.5	0.3	-0.2	0.2	-0.2	0.3	0.4	-0.2	-1.5	0.4	-0.2	0.1	-0.4	0.3	-0.2
Time in closed arm after self-admin	0.2	0.2	0.7	0.2	0.4	0.2	-0.2	0.1	-0.1	0.7	-0.6	-0.4	0.1	0.8	-0.1	0.1	-0.1	0.7	-0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.1	0.1	0.5	-0.5	0.4	-0.4	0.7	-0.3	-0.5	-0.6	0.2	-0.4	0.4	-0.5	0.5	-0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.6	0.3	0.4	-0.4	0.5	-0.4	-0.3	-0.2	0.0	0.7	-0.4	-0.4	0.4	-0.3	-0.2	-0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.5	-0.4	-0.5	0.7	-0.4	0.5	-0.4	0.4	0.3	-0.3	-0.4	0.5	-0.6	0.6	-0.4	0.7
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.4	-0.5	-0.6	0.5	-0.6	0.7	-0.2	0.4	0.4	-0.4	-0.5	0.6	-0.4	0.6	-0.1	0.5
Vertical activity count, locomotor time 2	0.2	0.3	0.8	0.4	0.7	0.3	-0.3	0.5	-0.3	0.7	-0.6	-0.6	0.4	0.9	-0.2	0.4	-0.2	0.8	-0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	2.3	0.8	0.5	-0.3	0.3	-0.4	0.3	-0.3	-0.4	0.2	1.5	-0.4	0.3	-0.3	0.5	-0.3	0.3
Mn content in liver	0.2	0.2	0.5	-0.6	-0.5	-0.2	0.5	-0.5	0.4	-0.1	0.4	0.2	-0.7	-0.0	0.5	-0.5	0.5	0.1	0.5
Heart weight	0.1	0.1	0.3	-0.0	0.0	0.3	-0.5	0.4	-0.3	0.2	0.0	-0.2	-0.3	0.1	-0.4	0.4	-0.6	0.1	-0.5
Number of licking bursts	0.1	0.1	0.6	0.5	0.5	0.1	-0.2	-0.0	-0.1	0.2	-0.4	-0.2	0.7	0.2	-0.2	0.3	-0.1	0.2	-0.2
Food consumed during 24 hour testing period	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.2	-0.5	0.5	-0.3	0.6	0.3	-0.7	-0.2	0.2	-0.1	0.4	-0.3	0.2
Indifference point 0 sec	0.1	0.2	0.4	-0.6	-0.5	-0.5	0.5	-0.5	0.4	-0.2	0.5	0.3	-0.6	-0.2	0.5	-0.4	0.5	-0.2	0.5
Delay discounting water rate 6 sec	0.1	0.2	0.3	0.0	-0.1	-0.3	0.5	-0.6	0.5	-0.4	0.2	0.4	0.6	-0.1	0.5	-0.5	0.6	-0.2	0.5
Locomotor activity	0.1	0.1	0.4	-0.1	-0.4	-0.1	0.1	0.0	-0.0	-0.6	0.4	0.5	-0.1	-0.5	-0.1	-0.0	-0.2	-0.6	0.1
Reaction time mean	0.1	0.1	0.2	0.4	0.4	0.3	-0.1	0.3	-0.1	0.4	-0.4	-0.3	0.4	0.4	-0.2	0.1	-0.2	0.3	-0.1
Reaction time mean AUC	0.1	0.1	0.5	0.4	0.4	0.0	0.1	0.1	0.2	0.2	-0.3	-0.1	0.7	0.2	0.1	-0.1	0.1	0.1	0.1
Conditioned locomotion	0.1	0.1	0.5	0.5	0.5	0.2	0.2	-0.1	-0.2	0.4	-0.7	-0.3	0.7	0.3	0.3	-0.3	0.3	0.3	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	0.3	0.3	0.5	-0.5	0.6	-0.4	0.1	-0.2	-0.2	0.2	0.3	-0.5	0.5	-0.5	0.2	-0.5
Intermittent access total locomotion	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.2	-0.4	0.2	-0.5	0.2	0.4	0.4	-0.4	0.2	-0.2	0.2	-0.5	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.0	-0.2	0.2	-0.2	0.4	0.2	-0.5	-0.3	0.1	0.0	0.2	-0.1	0.0
Short access day 10 total locomotion	0.1	0.1	0.9	0.5	0.5	0.5	-0.1	0.3	-0.3	-0.1	-0.4	-0.1	0.9	0.3	-0.3	0.2	-0.2	-0.0	-0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.3	0.4	0.1	0.1	-0.1	0.0	0.3	-0.6	-0.2	0.4	0.2	0.2	-0.2	0.1	0.3	0.1
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.2	-0.0	0.2	0.1	0.0	-0.2	0.4	-0.3	-0.3	-0.6	0.4	0.0	-0.0	-0.1	0.5	0.1
Novelty place preference	0.1	0.1	0.3	0.1	-0.1	-0.2	0.2	-0.1	0.2	-0.4	0.3	0.3	0.4	-0.6	0.1	-0.2	0.3	-0.4	0.2
Time in novel zone, NPP test	0.1	0.1	0.4	-0.1	-0.2	-0.3	0.2	-0.1	0.2	-0.5	0.4	0.3	0.1	-0.6	0.1	-0.2	0.3	-0.4	0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.0	-0.1	-0.4	0.3	-0.3	0.3	-0.5	0.3	0.4	0.5	-0.6	0.3	-0.3	0.4	-0.7	0.3
Bone: periosteal estimation	0.1	0.2	1.1	0.7	0.5	0.2	-0.4	0.2	-0.1	-0.3	-0.3	0.0	1.1	-0.1	-0.3	0.3	-0.2	-0.2	-0.4
Bone: post-yield work	0.1	0.2	0.5	-0.1	-0.0	0.5	-0.4	0.5	-0.5	0.4	-0.1	-0.3	-0.7	0.5	-0.4	0.3	-0.7	0.4	-0.4
Bone: trabecular thickness	0.1	0.1	0.6	-0.6	-0.4	-0.3	0.4	-0.3	0.4	0.1	0.4	0.1	-0.8	-0.1	0.4	-0.4	0.3	-0.1	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.2	-0.2	0.2	-0.4	0.4	0.3	-0.2	-0.5	0.2	-0.2	0.2	-0.2	0.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.1	0.1	0.1	-0.2	0.2	-0.1	0.7	-0.2	-0.4	-0.3	0.5	-0.1	0.1	-0.2	0.6	-0.2
Bouts of movement, locomotor time 1	0.1	0.2	0.3	-0.4	-0.4	-0.5	0.4	-0.5	0.6	-0.0	0.4	0.2	-0.5	-0.3	0.5	-0.3	0.4	0.0	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.3	-0.4	-0.3	0.4	-0.3	0.3	-0.6	0.5	0.5	-0.1	-0.4	0.3	-0.2	0.3	-0.5	0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.6	0.4	0.3	-0.4	0.6	-0.4	0.1	-0.3	-0.2	0.4	0.1	-0.5	0.5	-0.4	0.2	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.2	0.4	0.2	-0.1	-0.3	-0.1	0.4	-0.4	-0.3	0.3	0.5	-0.0	0.1	-0.0	0.5	-0.1
Co content in liver	0.1	0.1	0.3	0.4	0.3	0.1	-0.3	0.2	-0.3	-0.2	-0.1	0.0	0.6	-0.2	-0.3	0.3	-0.1	-0.1	-0.3
Mg content in liver	0.1	0.1	0.2	-0.1	-0.1	-0.1	0.2	-0.4	0.3	-0.3	0.2	0.2	0.2	-0.3	0.3	-0.2	0.4	-0.3	0.2
BMI without tail	0.0	0.1	0.4	-0.4	-0.4	0.0	-0.3	0.1	0.0	-0.3	0.3	0.2	-0.6	-0.3	-0.2	0.3	-0.1	-0.3	-0.3
Retroperitoneal fat weight	0.0	0.1	0.3	0.2	0.1	0.1	-0.2	0.5	-0.3	-0.2	-0.0	0.1	0.2	-0.6	-0.3	-0.0	-0.3	-0.4	-0.2
Delay discounting water rate 12 sec	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.1	-0.0	0.0	-0.3	0.3	0.3	-0.1	0.1	-0.1	0.0	-0.1	-0.2	-0.1
Locomotor testing distance	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.2	0.1	-0.3	0.2	0.2	-0.1	-0.4	0.0	-0.1	-0.0	-0.2	0.2
Light reinforcement 1	0.0	0.1	0.2	-0.3	-0.3	-0.3	0.2	-0.3	0.3	-0.3	0.4	0.3	-0.2	-0.4	0.3	-0.3	0.2	-0.3	0.2
Reaction time number correct	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.0	0.1	-0.2	-0.1	0.2	0.1	-0.3	-0.1	-0.1	-0.0	-0.2	-0.1	-0.0
Reaction time trials correct on left	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.0	0.1	-0.2	-0.1	0.2	0.1	-0.3	-0.1	-0.1	-0.0	-0.2	-0.1	-0.0
Reaction time trials on left	0.0	0.0	0.1	-0.2	-0.2	0.1	0.0	0.1	-0.1	-0.2	0.2	0.1	-0.3	-0.1	-0.0	-0.1	-0.1	-0.2	0.0
Reaction time omissions	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.3	-0.2	0.3	-0.2	-0.3	0.1	0.1	-0.2	0.1	-0.1	0.3	-0.2
Reaction time trials completed	0.0	0.0	0.1	-0.2	-0.2	0.1	0.0	0.1	-0.1	-0.2	0.2	0.1	-0.3	-0.1	-0.0	-0.1	-0.1	-0.2	0.0
Reaction time trials AUC	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	-0.3	-0.1	-0.0	-0.1	-0.1	-0.2	0.0
Conditioned locomotion	0.0	0.1	0.1	0.0	-0.0	0.0	0.3	-0.2	0.1	-0.4	0.1	0.2	0.3	-0.2	0.2	-0.2	0.2	-0.4	0.3
Locomotion velocity, hab. session 2	0.0	0.1	0.2	-0.1	0.0	0.2	0.0	0.1	-0.2	0.4	-0.3	-0.3	-0.5	0.4	-0.0	-0.0	-0.1	0.5	0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.0	-0.1	0.1	-0.2	0.3	0.2	-0.4	-0.2	-0.0	-0.0	0.0	-0.1	-0.0
Bone: cortical porosity	0.0	0.0	0.1	0.0	0.0	0.1	-0.2	0.1	-0.2	0.0	-0.0	-0.0	-0.0	0.0	-0.3	0.2	-0.1	0.0	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.2	0.2	0.0	0.1	-0.2	0.4	-0.2	-0.0	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2	0.0	-0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3	0.3	-0.2	0.0	0.0	-0.1	-0.1	0.0	-0.3	0.3	-0.2	0.1	-0.3

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.