Hub : Traits

Bone: marrow area

Tags: Physiology · Bone

Project: r01_doug_adams

3 loci · 9 genes with independent associations · 228 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr9	83390749	84777604	1	1	0.00e+00	2.42e-02	1.00e+00	Retreg2
2	chr10	89949449	99592963	225	7	2.07e-16	4.57e-16	NaN	C10h17orf58 Ccdc47 Fam20a LOC102549836 LOC102550782 LOC134480722 Map2k6
3	chr10	103498083	104679470	2	1	6.24e-08	8.24e-05	3.09e-01	Cyth1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	1921.71	2	1	11.1	0	1.00e+00	Retreg2 Wipi1
BMI without tail	2942.16	20	1	11.1	0.99	1.39e-41	Abca5 Abca6 Abca8 Arsg Axin2 C10h17orf58 Fam20a Helz Kcnj16 LOC100912202 LOC102550782 Map2k6 Pecam1 Prkar1a Prr29 Retreg2 Slc16a6 Strada Tex2 Wipi1
Body weight	5.33	46	17	188.9	0.28	5.63e-04	Abca5 Abca6 Ace Amz2 Apoh Arsg Bptf C10h17orf58 Ccdc47 Cep112 Cep95 Cyb561 Dcaf7 Ddx42 Ern1 Fam20a Ftsj3 Helz Icam2 Kpna2 Limd2 LOC102550334 LOC120095198 LOC120095199 LOC120095200 LOC120095203 LOC134480889 LOC134480894 Map2k6 Map3k3 Marchf10 Mrc2 Pecam1 Polg2 Prkar1a Prkca Prr29 Retreg2 Rgs9 Scn4a Snord104 Strada Taco1 Tanc2 Tex2 Wipi1
Epididymis fat weight	54223.41	2	1	11.1	0	1.00e+00	LOC102549836 Retreg2
Glucose	2366.35	1	1	11.1	0	1.00e+00	Retreg2
Heart weight	13509	1	1	11.1	0	1.00e+00	Retreg2
Left kidney weight	141259.46	1	1	11.1	0	1.00e+00	Retreg2
Right kidney weight	116847.14	1	1	11.1	0	1.00e+00	Retreg2
Tail length	7679.31	10	1	11.1	1	2.92e-15	Abca5 Ace Ddx42 Icam2 LOC134480894 Map2k6 Pecam1 Prr29 Retreg2 Strada
Length with tail	153.63	17	1	11.1	1	7.31e-49	Abca5 Amz2 Apoh Arsg Ccdc47 Cep112 Fam20a LOC102549836 LOC120095198 LOC120095199 LOC120095203 LOC134480894 Prkar1a Prkca Retreg2 Rgs9 Tex2
Length without tail	129313.22	1	1	11.1	0	1.00e+00	Retreg2
Liver weight, left	14514.29	1	1	11.1	0	1.00e+00	Retreg2
Liver weight, right	252.56	1	1	11.1	0	1.00e+00	Retreg2
Parametrial fat weight	615.65	1	1	11.1	0	1.00e+00	Retreg2
Retroperitoneal fat weight	16055.76	1	1	11.1	0	1.00e+00	Retreg2
Intraocular pressure	40071.91	1	1	11.1	0	1.00e+00	Retreg2
Extensor digitorum longus weight	264.61	12	1	11.1	0.98	2.93e-12	Ace C10h17orf58 Ccdc47 Cyb561 Icam2 Kcnh6 LOC120095200 Marchf10 Retreg2 Scn4a Taco1 Tlk2
Soleus weight	115.65	1	1	11.1	0	1.00e+00	Retreg2
Tibialis anterior weight	4881.94	1	1	11.1	0	1.00e+00	Retreg2
Tibia length	3259.43	1	1	11.1	0	1.00e+00	Retreg2
Number of licking bursts	157119.65	1	1	11.1	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	106196.53	1	1	11.1	0	1.00e+00	Retreg2
Times rat made contact with spout	305.36	1	1	11.1	0	1.00e+00	Retreg2
Mean time between licks in bursts	199507.71	1	1	11.1	0	1.00e+00	Retreg2
Mean num. licks in bursts	142600.29	1	1	11.1	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	94042.02	1	1	11.1	0	1.00e+00	Retreg2
Water consumed over 24 hours	103408.69	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	115003.89	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging indifference point AUC	133114.6	1	1	11.1	0	1.00e+00	Retreg2
Indifference point function ln k	142006.4	1	1	11.1	0	1.00e+00	Retreg2
Indifference point function log k	142006.4	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 0 sec	120264.14	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 12 sec	10848.8	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 18 sec	117768.16	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 24 sec	167090.22	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 6 sec	32639.62	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging time to switch 0 sec	156618.53	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	148807.58	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	161858.08	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	103280.07	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 24 sec	4691.77	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 6 sec	3954.86	1	1	11.1	0	1.00e+00	Retreg2
Locomotor activity	12.34	1	0	0	0	1.00e+00	Retreg2
Locomotor testing distance	89448.55	1	1	11.1	0	1.00e+00	Retreg2
Locomotor testing rearing	76209.52	2	1	11.1	0	1.00e+00	Kcnj2 Retreg2
Light reinforcement 1	155242.72	1	1	11.1	0	1.00e+00	Retreg2
Light reinforcement 2	107899.08	1	1	11.1	0	1.00e+00	Retreg2
Reaction time number correct	153465.22	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean minus median	205810.62	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean minus median AUC	208396.98	1	1	11.1	0	1.00e+00	Retreg2
Reaction time num false alarms	57075.22	1	1	11.1	0	1.00e+00	Retreg2
Reaction time num false alarms AUC	106496.51	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials correct on left	153465.22	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials on left	149991.58	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean	94380.53	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean AUC	113341.21	1	1	11.1	0	1.00e+00	Retreg2
Median of all reaction times	31417.12	1	1	11.1	0	1.00e+00	Retreg2
Reaction time omissions	34267.91	1	1	11.1	0	1.00e+00	Retreg2
Reaction time false alarm rate	891.26	1	1	11.1	0	1.00e+00	Retreg2
Reaction time premature initiation rate	36877.02	1	1	11.1	0	1.00e+00	Retreg2
Reaction time premature initiations	138718.63	1	1	11.1	0	1.00e+00	Retreg2
Std. dev. reaction times	149487.71	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials completed	149991.58	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials AUC	151696.42	1	1	11.1	0	1.00e+00	Retreg2
Social response proportion	35302.65	1	1	11.1	0	1.00e+00	Retreg2
Social responses	5682.08	1	1	11.1	0	1.00e+00	Retreg2
Social time	44238.34	1	1	11.1	0	1.00e+00	Retreg2
Conditioned locomotion	6074.35	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	65812.39	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	64247.35	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response before conditioning	2800.41	1	1	11.1	0	1.00e+00	Retreg2
Saline control response	12962.78	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	53410.48	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	91582.24	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active responses	1947.62	4	1	11.1	-0.99	7.07e-04	C10h17orf58 Pecam1 Retreg2 Wipi1
Condit. Reinf. inactive responses	42106.18	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	15873.43	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. lever reinforcers received	2000.77	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	10912.53	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	49418.79	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	114781.94	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. index score	47988.08	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	58476.16	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	22069.78	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	16773.11	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	538.7	32	1	11.1	-0.93	1.52e-84	Ace Bptf C10h17orf58 Ccdc47 Cep95 Dcaf7 Ddx42 Ddx5 Ern1 Ftsj3 Helz Icam2 Kcnh6 Kpna2 Limd2 LOC134480889 Map3k3 Mrc2 Pecam1 Polg2 Prr29 Psmd12 Retreg2 Scn4a Smurf2 Snord104 Strada Taco1 Tanc2 Tcam1 Tex2 Tlk2
Pavlov. Cond. lever-magazine prob. diff.	44871.67	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	5169.79	1	1	11.1	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	191492.54	1	1	11.1	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	155032.91	1	1	11.1	0	1.00e+00	Retreg2
Conditioned locomotion	41346.85	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access intake day 1-15 change	210605.99	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access intake escalation	209543.53	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access intake escalation 2	107995.31	1	1	11.1	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	236542.72	1	1	11.1	0	1.00e+00	Retreg2
Intermitt. access day 15 inactive lever presses	208241.66	1	1	11.1	0	1.00e+00	Retreg2
Intermitt. access escalation Index	184996.65	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 1 total infusions	155525.68	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 15 total infusions	131485.34	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	83205.14	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access total infusions	675.9	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 1 locomotion	104459.41	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	177836.92	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access total locomotion	67.96	7	1	11.1	0.92	1.07e-05	C10h17orf58 Cep112 Helz Pecam1 Prr29 Retreg2 Tex2
Intermittent access standard deviation	100954.65	2	1	11.1	0	1.00e+00	Prkca Retreg2
Cocaine induced anxiety	160280.46	1	1	11.1	0	1.00e+00	Retreg2
Post-drug Anxiety	20460.83	1	1	11.1	0	1.00e+00	Retreg2
Baseline Anxiety	103471.3	1	1	11.1	0	1.00e+00	Retreg2
Lifetime Intake	6830.03	1	1	11.1	0	1.00e+00	Retreg2
Incentive Sensitization - Responses	163579.25	1	1	11.1	0	1.00e+00	Retreg2
Incentive Sensitization - Breakpoint	142790.8	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 active lever presses	99872.69	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	96247.61	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	151100.07	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 2 active lever presses	57222.6	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 2 breakpoint	34975.96	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	164104.71	1	1	11.1	0	1.00e+00	Retreg2
Total sessions with >9 infusions	7953.9	1	1	11.1	0	1.00e+00	Retreg2
Short access day 1 total inactive lever presses	114392.27	1	1	11.1	0	1.00e+00	Retreg2
Short access day 10 total inactive lever presses	217140.65	1	1	11.1	0	1.00e+00	Retreg2
Short access day 1 total infusions	111479.43	1	1	11.1	0	1.00e+00	Retreg2
Short access day 10 total infusions	76293.54	1	1	11.1	0	1.00e+00	Retreg2
Short access total infusions	33946.03	1	1	11.1	0	1.00e+00	Retreg2
Short access day 1 locomotion	84055.65	1	1	11.1	0	1.00e+00	Retreg2
Short access day 10 total locomotion	181597.84	1	1	11.1	0	1.00e+00	Retreg2
Short access total locomotion	68266.59	1	1	11.1	0	1.00e+00	Retreg2
Compulsive drug intake	65439.45	1	1	11.1	0	1.00e+00	Retreg2
One hour access (0.3 mA shock)	9669.44	1	1	11.1	0	1.00e+00	Retreg2
One hour access (shock baseline)	140263.4	1	1	11.1	0	1.00e+00	Retreg2
Number of responses in last shaping day	51289.19	1	1	11.1	0	1.00e+00	Retreg2
Context. condit. distance diff. score	970.59	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 1	14615.25	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 1	4416.18	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 2	9358	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 2	2393.66	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 3	2332.53	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 3	16615.78	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	5866.4	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	12131.92	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 7	1310.17	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 7	3744.54	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 7	10466.92	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	8847.36	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 8	1892.98	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 8	673.32	1	1	11.1	0	1.00e+00	Retreg2
Degree of sensitization distance	15309.16	1	1	11.1	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	8496.38	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	4120.78	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	1097.66	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active responses	11664.93	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	19375.3	1	1	11.1	0	1.00e+00	Retreg2
Incentive salience index mean	14781.83	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	21433.81	1	1	11.1	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	41873.03	1	1	11.1	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	35522.88	1	1	11.1	0	1.00e+00	Retreg2
Total zone transitions, hab. session 1	1818.53	1	1	11.1	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	1687	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	1131.06	1	1	11.1	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	23379.25	1	1	11.1	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	24924.95	1	1	11.1	0	1.00e+00	Retreg2
Total zone transitions, hab. session 2	280.53	1	1	11.1	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 2	96.8	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	145.53	1	1	11.1	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	55508.81	1	1	11.1	0	1.00e+00	Retreg2
Novelty place preference	54383.96	1	1	11.1	0	1.00e+00	Retreg2
Time in novel zone, NPP test	40844.77	1	1	11.1	0	1.00e+00	Retreg2
Total zone transitions, NPP test	8230.03	1	1	11.1	0	1.00e+00	Retreg2
Total locomotion distance, NPP test	7114	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	4041.22	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	2195.61	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	4539.35	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. index score	1769.33	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	1841.19	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	3029.77	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	2162.19	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	524.02	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	1940.27	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	2606.99	1	1	11.1	0	1.00e+00	Retreg2
Bone: apparent density	22268.03	1	1	11.1	0	1.00e+00	Retreg2
Bone surface	319.99	26	3	33.3	1	3.02e-136	Abca5 Abca8 Abca9 Arsg Axin2 Ccdc47 Cyb561 Fam20a Gna13 Icam2 Kcnh6 Kcnj16 Kcnj2 LOC100912202 LOC102550782 LOC120095203 LOC120095206 LOC134480721 LOC134480722 Map2k6 Prkar1a Retreg2 Scn4a Slc16a6 Taco1 Tlk2
Bone volume	744.13	14	1	11.1	1	7.90e-70	Abca8 Abca9 Axin2 Ccdc47 Fam20a Gna13 Kcnj16 Kcnj2 LOC100912202 LOC120095203 LOC134480721 Map2k6 Prkar1a Retreg2
Bone: connectivity density	7098.55	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical apparent density	45266.32	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical area	18930.98	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical porosity	61.14	15	4	44.4	-0.77	2.17e-09	Ace Ccdc47 Cyb561 Dcaf7 Icam2 Kcnh6 LOC108352146 LOC134480889 Marchf10 Mrc2 Prr29 Retreg2 Scn4a Taco1 Tlk2
Bone: cortical porosity	300	10	2	22.2	0.99	6.15e-13	Cyb561 Dcaf7 Kcnh6 LOC108352146 LOC134480889 Marchf10 Mrc2 Prr29 Retreg2 Tlk2
Bone: cortical thickness	21.36	43	11	122.2	-0.83	3.58e-45	Abca5 Abca6 Abca8 Abca8a Abca9 Amz2 Arsg Bptf Ccdc47 Cep112 Cep95 Cyth1 Ddx42 Ddx5 Fam20a Helz Icam2 Kcnj16 Kcnj2 Kpna2 Limd2 LOC100912202 LOC102546698 LOC102549521 LOC102549836 LOC108352151 LOC120095197 LOC120095203 LOC120095206 LOC134480721 LOC134480722 Map2k6 Nol11 Pecam1 Pitpnc1 Prkar1a Prr29 Retreg2 Scn4a Smurf2 Snord104 Strada Tex2
Bone: cortical thickness	12190.6	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical tissue density	48453.42	1	1	11.1	0	1.00e+00	Retreg2
Bone: elastic displacement	29626.25	1	1	11.1	0	1.00e+00	Retreg2
Bone: elastic work	1494.59	1	1	11.1	0	1.00e+00	Retreg2
Bone: endosteal estimation	73.97	85	85	944.4	1	0.00e+00	Abca5 Abca6 Abca8 Abca8a Abca9 Ace Amz2 Apoh Arsg Axin2 Bptf C10h17orf58 Cacng4 Cacng5 Ccdc47 Cep112 Cep95 Cyb561 Cyth1 Dcaf7 Ddx42 Ddx5 Ern1 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kcnj16 Kcnj2 Kpna2 Limd2 LOC100912202 LOC102546698 LOC102549521 LOC102549596 LOC102549836 LOC102550334 LOC102550782 LOC102551705 LOC103693474 LOC108352146 LOC108352150 LOC108352151 LOC108352227 LOC120095197 LOC120095198 LOC120095199 LOC120095200 LOC120095203 LOC120095206 LOC120095210 LOC134480640 LOC134480721 LOC134480722 LOC134480889 LOC134480890 LOC134480892 LOC134480894 Map2k6 Map3k3 Marchf10 Mrc2 Nol11 Pecam1 Pitpnc1 Polg2 Prkar1a Prkca Prr29 Psmd12 Retreg2 Rgs9 Scn4a Slc16a6 Smurf2 Snord104 Strada Taco1 Tanc2 Tcam1 Tex2 Tlk2 Wipi1
Bone: endosteal perimeter	89.32	85	83	922.2	1	0.00e+00	Abca5 Abca6 Abca8 Abca8a Abca9 Ace Amz2 Apoh Arsg Axin2 Bptf C10h17orf58 Cacng4 Cacng5 Ccdc47 Cep112 Cep95 Cyb561 Cyth1 Dcaf7 Ddx42 Ddx5 Ern1 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kcnj16 Kcnj2 Kpna2 Limd2 LOC100912202 LOC102546698 LOC102549521 LOC102549596 LOC102549836 LOC102550334 LOC102550782 LOC102551705 LOC103693474 LOC108352146 LOC108352150 LOC108352151 LOC108352227 LOC120095197 LOC120095198 LOC120095199 LOC120095200 LOC120095203 LOC120095206 LOC120095210 LOC134480640 LOC134480721 LOC134480722 LOC134480889 LOC134480890 LOC134480892 LOC134480894 Map2k6 Map3k3 Marchf10 Mrc2 Nol11 Pecam1 Pitpnc1 Polg2 Prkar1a Prkca Prr29 Psmd12 Retreg2 Rgs9 Scn4a Slc16a6 Smurf2 Snord104 Strada Taco1 Tanc2 Tcam1 Tex2 Tlk2 Wipi1
Bone: final force	7031.22	1	1	11.1	0	1.00e+00	Retreg2
Bone: final moment	1042.62	1	1	11.1	0	1.00e+00	Retreg2
Bone: maximum diameter	507.66	13	1	11.1	1	1.17e-85	Abca5 Cyb561 Kcnj16 Kcnj2 LOC102549596 LOC102549836 LOC103693474 LOC120095206 LOC120095210 LOC134480640 LOC134480721 LOC134480722 Retreg2
Bone: maximum force	34553.99	1	1	11.1	0	1.00e+00	Retreg2
Bone: maximum moment	24715.64	1	1	11.1	0	1.00e+00	Retreg2
Bone: minimum diameter	45.65	80	35	388.9	0.99	0.00e+00	Abca5 Abca6 Abca8 Abca8a Abca9 Ace Amz2 Apoh Arsg Axin2 Bptf C10h17orf58 Cacng4 Cacng5 Ccdc47 Cep112 Cep95 Cyb561 Dcaf7 Ddx42 Ddx5 Ern1 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kcnj16 Kcnj2 Kpna2 Limd2 LOC100912202 LOC102546698 LOC102549836 LOC102550334 LOC102550782 LOC102551705 LOC108352146 LOC108352150 LOC108352151 LOC108352227 LOC120095197 LOC120095198 LOC120095199 LOC120095200 LOC120095203 LOC120095206 LOC120095210 LOC134480721 LOC134480722 LOC134480889 LOC134480890 LOC134480892 LOC134480894 Map2k6 Map3k3 Marchf10 Mrc2 Nol11 Pecam1 Pitpnc1 Polg2 Prkar1a Prkca Prr29 Psmd12 Retreg2 Rgs9 Scn4a Slc16a6 Smurf2 Snord104 Strada Taco1 Tanc2 Tcam1 Tex2 Tlk2 Wipi1
Bone: periosteal estimation	89.23	80	22	244.4	1	0.00e+00	Abca5 Abca6 Abca8 Abca8a Abca9 Ace Amz2 Apoh Arsg Axin2 Bptf C10h17orf58 Cacng4 Cacng5 Ccdc47 Cep112 Cep95 Cyb561 Dcaf7 Ddx42 Ddx5 Ern1 Fam20a Ftsj3 Gna13 Helz Icam2 Kcnh6 Kcnj16 Kcnj2 Kpna2 Limd2 LOC100912202 LOC102549596 LOC102549836 LOC102550334 LOC102550782 LOC102551705 LOC103693474 LOC108352146 LOC108352150 LOC108352151 LOC108352227 LOC120095197 LOC120095198 LOC120095199 LOC120095200 LOC120095203 LOC120095206 LOC120095210 LOC134480640 LOC134480721 LOC134480722 LOC134480889 LOC134480890 LOC134480892 LOC134480894 Map2k6 Map3k3 Marchf10 Mrc2 Pecam1 Pitpnc1 Polg2 Prkar1a Prkca Prr29 Psmd12 Retreg2 Rgs9 Scn4a Slc16a6 Smurf2 Snord104 Strada Taco1 Tanc2 Tex2 Tlk2 Wipi1
Bone: periosteal perimeter	643.63	20	1	11.1	1	9.68e-87	Abca5 Abca6 Abca8 Abca8a Arsg Ccdc47 Cyb561 Dcaf7 Fam20a Gna13 Kcnh6 LOC120095200 LOC120095203 LOC134480722 LOC134480889 Marchf10 Prkar1a Retreg2 Rgs9 Wipi1
Bone: post-yield work	50847.58	1	1	11.1	0	1.00e+00	Retreg2
Bone: stiffness	35564.91	1	1	11.1	0	1.00e+00	Retreg2
Bone: tissue strength	12264.67	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular number	41138.39	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular spacing	31287.85	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular thickness	33264.33	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular tissue density	53620.06	1	1	11.1	0	1.00e+00	Retreg2
Breakpoint value in progressive ratio session	112428.06	1	1	11.1	0	1.00e+00	Retreg2
Distance traveled before self-admin	134013.73	1	1	11.1	0	1.00e+00	Retreg2
Distance traveled after self-admin	100820.36	1	1	11.1	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	1271.86	1	1	11.1	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	54811.83	1	1	11.1	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	108490.77	1	1	11.1	0	1.00e+00	Retreg2
Extinction: sum of active levers before priming	91573.47	1	1	11.1	0	1.00e+00	Retreg2
Active lever presses in extinction session 6	3117.3	1	1	11.1	0	1.00e+00	Retreg2
Delta distance traveled before/after self-admin	12434.77	1	1	11.1	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	96034.01	1	1	11.1	0	1.00e+00	Retreg2
Time in closed arm before self-admin	88239.28	1	1	11.1	0	1.00e+00	Retreg2
Time in closed arm after self-admin	19471.75	1	1	11.1	0	1.00e+00	Retreg2
Time in open arm before self-admin	34587.99	1	1	11.1	0	1.00e+00	Retreg2
Time in open arm after self-admin	1894.09	1	1	11.1	0	1.00e+00	Retreg2
Sum of active levers in priming session hrs 5-6	3877.89	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	51335.42	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, vehicle, after self-admin	118286.85	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	32803.11	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, test, after self-admin	5828.87	1	1	11.1	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	36533.83	1	1	11.1	0	1.00e+00	Retreg2
Delta time to tail flick, test, before/after SA	56832.34	1	1	11.1	0	1.00e+00	Retreg2
Ambulatory time before self-admin	171079.71	1	1	11.1	0	1.00e+00	Retreg2
Ambulatory time after self-admin	88230.17	1	1	11.1	0	1.00e+00	Retreg2
Total heroin consumption	961.5	1	1	11.1	0	1.00e+00	Retreg2
Area under the delay curve	81605.23	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	9477.47	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	74803.61	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	825.84	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	99983.64	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 4s delay	2525.7	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	101423.99	1	1	11.1	0	1.00e+00	Retreg2
Delay discount exponential model param	60214.95	1	1	11.1	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	45715.54	1	1	11.1	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	150160.89	1	1	11.1	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	23481.3	1	1	11.1	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	49255.61	1	1	11.1	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	41590.88	1	1	11.1	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	11802.64	1	1	11.1	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	75951.88	1	1	11.1	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	159283.67	1	1	11.1	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	219061.96	1	1	11.1	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	161986.9	1	1	11.1	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	174298.32	1	1	11.1	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	190079.87	1	1	11.1	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	83778.18	1	1	11.1	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	34268.85	1	1	11.1	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	138414.05	1	1	11.1	0	1.00e+00	Retreg2
Weight adjusted by age	161973.18	1	1	11.1	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	49395.56	1	1	11.1	0	1.00e+00	Retreg2
Locomotion in novel chamber	16301.47	1	1	11.1	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	154642.04	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio	157894.89	1	1	11.1	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	7338.76	1	1	11.1	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	118281.2	1	1	11.1	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	37174.37	1	1	11.1	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	29861.56	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	58575.8	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	28379.24	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	7140.1	1	1	11.1	0	1.00e+00	Retreg2
Co content in liver	4721.74	1	1	11.1	0	1.00e+00	Retreg2
Cu content in liver	162.43	1	1	11.1	0	1.00e+00	Retreg2
Fe content in liver	5656.2	1	1	11.1	0	1.00e+00	Retreg2
K content in liver	6593.53	1	1	11.1	0	1.00e+00	Retreg2
Mg content in liver	24493.99	1	1	11.1	0	1.00e+00	Retreg2
Mn content in liver	4374.36	1	1	11.1	0	1.00e+00	Retreg2
Na content in liver	16641.94	1	1	11.1	0	1.00e+00	Retreg2
Rb content in liver	428.45	1	1	11.1	0	1.00e+00	Retreg2
Zn content in liver	15755.62	1	1	11.1	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	7	0.2	1.9
Adipose	alternative TSS	18	0.5	2.11
Adipose	gene expression	17	0.2	2
Adipose	isoform ratio	6	0.1	2
Adipose	intron excision ratio	3	0.1	2.68
Adipose	mRNA stability	9	0.2	2.05
BLA	alternative polyA	8	0.4	2.19
BLA	alternative TSS	5	0.2	2.09
BLA	gene expression	23	0.3	2.18
BLA	isoform ratio	6	0.2	2.11
BLA	intron excision ratio	5	0.2	2.22
BLA	mRNA stability	8	0.3	2.16
Brain	alternative polyA	5	0.1	2.02
Brain	alternative TSS	14	0.3	2.03
Brain	gene expression	27	0.3	2.07
Brain	isoform ratio	9	0.2	2.06
Brain	intron excision ratio	4	0.1	2.24
Brain	mRNA stability	15	0.3	2.03
Eye	alternative polyA	0	0	2.43
Eye	alternative TSS	2	0.5	2.16
Eye	gene expression	5	0.4	2.26
Eye	isoform ratio	2	0.4	2.23
Eye	intron excision ratio	1	0.1	2.22
Eye	mRNA stability	1	0.3	2.23
IC	alternative polyA	2	0.1	2.2
IC	alternative TSS	7	0.4	2.06
IC	gene expression	24	0.4	2.18
IC	isoform ratio	3	0.1	2.13
IC	intron excision ratio	2	0.1	2.3
IC	mRNA stability	5	0.3	2.19
IL	alternative polyA	0	0	2.2
IL	alternative TSS	3	0.4	2.03
IL	gene expression	15	0.3	2.17
IL	isoform ratio	1	0.1	2.3
IL	intron excision ratio	0	0	2.48
IL	mRNA stability	5	0.4	2.06
LHb	alternative polyA	0	0	2.19
LHb	alternative TSS	0	0	1.89
LHb	gene expression	10	0.3	2.17
LHb	isoform ratio	0	0	2.14
LHb	intron excision ratio	1	0.1	2.11
LHb	mRNA stability	5	0.4	2.07
Liver	alternative polyA	13	0.5	2.25
Liver	alternative TSS	16	0.6	2.16
Liver	gene expression	18	0.2	2.05
Liver	isoform ratio	11	0.3	2.1
Liver	intron excision ratio	11	0.2	2.21
Liver	mRNA stability	10	0.3	2.07
NAcc	alternative polyA	10	0.3	27.58
NAcc	alternative TSS	6	0.2	2.05
NAcc	gene expression	31	0.3	2.11
NAcc	isoform ratio	7	0.1	2.04
NAcc	intron excision ratio	9	0.1	2.18
NAcc	mRNA stability	17	0.5	2.2
OFC	alternative polyA	0	0	2.17
OFC	alternative TSS	3	0.4	2.23
OFC	gene expression	12	0.3	2.15
OFC	isoform ratio	0	0	2.08
OFC	intron excision ratio	0	0	2.13
OFC	mRNA stability	1	0.1	2.02
PL	alternative polyA	8	0.2	2.09
PL	alternative TSS	7	0.2	2.08
PL	gene expression	33	0.3	2.12
PL	isoform ratio	9	0.2	2.15
PL	intron excision ratio	4	0.1	2.21
PL	mRNA stability	17	0.4	2.11
pVTA	alternative polyA	4	0.2	2.11
pVTA	alternative TSS	5	0.2	2.1
pVTA	gene expression	31	0.4	2.17
pVTA	isoform ratio	3	0.1	2.11
pVTA	intron excision ratio	4	0.1	2.25
pVTA	mRNA stability	5	0.2	2.07
RMTg	alternative polyA	1	0.1	2.05
RMTg	alternative TSS	0	0	1.94
RMTg	gene expression	3	0.1	2.16
RMTg	isoform ratio	2	0.2	2.11
RMTg	intron excision ratio	0	0	2.26
RMTg	mRNA stability	3	0.5	2.12