Best TWAS P = 2.79e-09 · Best GWAS P= 2.66e-09 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Atg7 | alternative polyA | XM_008763239.4 | 0.04 | 1 | 0.04 | 7.9e-05 | -5.63 | 1.81e-08 | 0.26 | FALSE |
| Adipose | Atg7 | alternative polyA | XM_063286089.1 | 0.04 | 1 | 0.03 | 1.1e-04 | 5.63 | 1.81e-08 | 0.24 | FALSE |
| Adipose | Atg7 | alternative polyA | XM_008763239.4 | 0.03 | 1 | 0.03 | 2.5e-04 | -5.63 | 1.81e-08 | 0.17 | FALSE |
| Adipose | Atg7 | alternative polyA | XM_063286089.1 | 0.03 | 1 | 0.03 | 2.8e-04 | 5.63 | 1.81e-08 | 0.16 | FALSE |
| Adipose | Vgll4 | alternative polyA | NM_001394032.1 | 0.11 | 1301 | 0.09 | 6.5e-10 | -5.3 | 1.15e-07 | 0.28 | FALSE |
| Adipose | Vgll4 | alternative polyA | XM_063285889.1 | 0.12 | 1301 | 0.09 | 4.5e-10 | 5.29 | 1.21e-07 | 0.28 | FALSE |
| Adipose | Vgll4 | alternative polyA | NM_001394032.1 | 0.17 | 1301 | 0.1 | 2.6e-11 | -5.5 | 3.87e-08 | 0.49 | FALSE |
| Adipose | Vgll4 | alternative polyA | XM_063285889.1 | 0.15 | 1301 | 0.1 | 3.5e-11 | 5.46 | 4.66e-08 | 0.46 | FALSE |
| Adipose | LOC120102369 | gene expression | LOC120102369 | 0.02 | 1533 | 0.01 | 7.6e-03 | -5.83 | 5.64e-09 | 0.52 | FALSE |
| Adipose | Tamm41 | gene expression | Tamm41 | 0.34 | 1372 | 0.34 | 1.3e-38 | 5.22 | 1.75e-07 | 0.01 | FALSE |
| Adipose | Timp4 | gene expression | Timp4 | 0.06 | 1 | 0.05 | 7.4e-06 | -5.89 | 3.86e-09 | 0.83 | FALSE |
| Adipose | Atg7 | isoform ratio | XM_008763239.4 | 0.05 | 1 | 0.05 | 1.2e-06 | -5.63 | 1.81e-08 | 0.58 | FALSE |
| Adipose | Tamm41 | isoform ratio | XM_039107861.2 | 0.05 | 1372 | 0.04 | 3.2e-05 | -5.89 | 3.85e-09 | 0.71 | FALSE |
| Adipose | Vgll4 | isoform ratio | XM_063285889.1 | 0.1 | 96 | 0.08 | 4.7e-09 | -5.26 | 1.46e-07 | 0.18 | FALSE |
| Adipose | Tamm41 | mRNA stability | Tamm41 | 0.12 | 1 | 0.11 | 1.3e-12 | -5.6 | 2.18e-08 | 0.56 | FALSE |
| BLA | Vgll4 | gene expression | Vgll4 | 0.35 | 1 | 0.27 | 1.6e-14 | -5.68 | 1.37e-08 | 0.66 | FALSE |
| BLA | Hrh1 | mRNA stability | Hrh1 | 0.06 | 1 | 0.04 | 4.5e-03 | -5.35 | 8.60e-08 | 0.04 | FALSE |
| Brain | Tamm41 | gene expression | Tamm41 | 0.12 | 1 | 0.09 | 1.2e-08 | -5.86 | 4.51e-09 | 0.85 | FALSE |
| Brain | Vgll4 | gene expression | Vgll4 | 0.22 | 41 | 0.21 | 3.2e-19 | -5.71 | 1.10e-08 | 0.11 | FALSE |
| IC | Tamm41 | gene expression | Tamm41 | 0.13 | 77 | 0.07 | 4.6e-04 | -5.32 | 1.03e-07 | 0.58 | FALSE |
| IC | Vgll4 | gene expression | Vgll4 | 0.28 | 1301 | 0.16 | 2.0e-07 | 5.88 | 4.15e-09 | 0.65 | FALSE |
| IC | Vgll4 | mRNA stability | Vgll4 | 0.26 | 18 | 0.18 | 5.2e-08 | -5.94 | 2.79e-09 | 0.69 | TRUE |
| IL | Tamm41 | gene expression | Tamm41 | 0.21 | 1 | 0.09 | 3.9e-03 | -5.62 | 1.89e-08 | 0.06 | FALSE |
| IL | Vgll4 | gene expression | Vgll4 | 0.25 | 1 | 0.16 | 1.3e-04 | -5.61 | 1.97e-08 | 0.06 | FALSE |
| LHb | Tamm41 | gene expression | Tamm41 | 0.31 | 286 | 0.11 | 1.4e-03 | -5.46 | 4.67e-08 | 0.59 | FALSE |
| LHb | Vgll4 | gene expression | Vgll4 | 0.25 | 1 | 0.13 | 6.8e-04 | -5.75 | 8.91e-09 | 0.06 | FALSE |
| Liver | Atg7 | alternative TSS | XM_063286089.1 | 0.02 | 1 | 0.02 | 2.3e-03 | -5.67 | 1.42e-08 | 0.05 | FALSE |
| Liver | Atg7 | gene expression | Atg7 | 0.14 | 1 | 0.19 | 7.3e-21 | 5.94 | 2.82e-09 | 0.9 | FALSE |
| Liver | Mkrn2os | gene expression | Mkrn2os | 0.09 | 11 | 0.07 | 7.5e-08 | 5.26 | 1.43e-07 | 0.01 | FALSE |
| Liver | Vgll4 | gene expression | Vgll4 | 0.06 | 21 | 0.06 | 6.4e-07 | -5.93 | 3.03e-09 | 0.7 | FALSE |
| Liver | Atg7 | mRNA stability | Atg7 | 0.03 | 1636 | 0.04 | 4.0e-05 | -5.57 | 2.58e-08 | 0.65 | FALSE |
| Liver | Tamm41 | mRNA stability | Tamm41 | 0.05 | 1 | 0.04 | 1.1e-05 | -5.8 | 6.73e-09 | 0.52 | FALSE |
| NAcc | Vgll4 | alternative TSS | NM_001394032.1 | 0.07 | 1301 | 0.07 | 1.1e-10 | 5.87 | 4.31e-09 | 0.72 | FALSE |
| NAcc | Vgll4 | alternative TSS | NM_001394032.1 | 0.07 | 1301 | 0.07 | 8.8e-11 | 5.86 | 4.52e-09 | 0.71 | FALSE |
| NAcc | Tamm41 | gene expression | Tamm41 | 0.15 | 1 | 0.13 | 1.8e-18 | -5.74 | 9.30e-09 | 0.74 | FALSE |
| NAcc | Vgll4 | gene expression | Vgll4 | 0.46 | 1301 | 0.5 | 9.0e-89 | 5.89 | 3.75e-09 | 0.64 | FALSE |
| NAcc | Vgll4 | isoform ratio | NM_001394032.1 | 0.06 | 1 | 0.06 | 6.1e-10 | -5.87 | 4.30e-09 | 0.86 | FALSE |
| NAcc | Vgll4 | intron excision ratio | chr4_149699768_149710081 | 0.03 | 1 | 0.03 | 9.4e-06 | 5.94 | 2.85e-09 | 0.72 | FALSE |
| NAcc | Vgll4 | intron excision ratio | chr4_149699768_149710919 | 0.03 | 1 | 0.03 | 1.2e-05 | -5.94 | 2.85e-09 | 0.69 | FALSE |
| NAcc | Syn2 | mRNA stability | Syn2 | 0.02 | 7 | 0.01 | 2.0e-02 | -5.79 | 7.11e-09 | 0.48 | FALSE |
| OFC | Vgll4 | gene expression | Vgll4 | 0.17 | 152 | 0.1 | 2.7e-03 | -5.86 | 4.74e-09 | 0.52 | FALSE |
| PL | Vgll4 | gene expression | Vgll4 | 0.36 | 59 | 0.26 | 7.8e-29 | -5.54 | 3.07e-08 | 0.64 | FALSE |
| PL | Hrh1 | mRNA stability | Hrh1 | 0.03 | 1 | 0.04 | 5.5e-05 | -5.67 | 1.41e-08 | 0.34 | FALSE |
| pVTA | Mkrn2 | alternative TSS | NM_001008314.1 | 0.09 | 1 | 0.05 | 9.5e-05 | 5.73 | 1.03e-08 | 0.69 | FALSE |
| pVTA | Mkrn2 | alternative TSS | NM_001008314.1 | 0.08 | 1 | 0.04 | 4.3e-04 | 5.73 | 1.03e-08 | 0.36 | FALSE |
| pVTA | Atg7 | gene expression | Atg7 | 0.04 | 1 | 0.07 | 3.2e-06 | 5.89 | 3.86e-09 | 0.72 | FALSE |
| pVTA | Tamm41 | gene expression | Tamm41 | 0.12 | 1 | 0.1 | 3.2e-08 | -5.73 | 1.03e-08 | 0.72 | FALSE |
| pVTA | Vgll4 | gene expression | Vgll4 | 0.24 | 4 | 0.23 | 1.6e-18 | 5.5 | 3.74e-08 | 0.46 | FALSE |
| pVTA | Atg7 | isoform ratio | XM_063286089.1 | 0.04 | 1636 | 0.03 | 1.0e-03 | 5.63 | 1.78e-08 | 0.24 | FALSE |
| pVTA | Vgll4 | mRNA stability | Vgll4 | 0.12 | 8 | 0.09 | 1.1e-07 | -5.47 | 4.47e-08 | 0.51 | FALSE |
| RMTg | Vgll4 | alternative polyA | XM_063285889.1 | 0.18 | 7 | 0.07 | 5.0e-03 | 5.71 | 1.16e-08 | 0.39 | FALSE |