# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | alternative TSS | ENSRNOT00000071928 | 0.2181 | 0.09190 | 3.9e-16 | 0.104 | 0.114 | 0.129 | 0.126 | 1.4e-11 | 1.4e-12 | 3.4e-14 | 7.2e-14 |
2 | Adipose | alternative TSS | ENSRNOT00000107172 | 0.2189 | 0.09240 | 3.9e-16 | 0.104 | 0.114 | 0.131 | 0.126 | 1.3e-11 | 1.4e-12 | 2.6e-14 | 7.0e-14 |
3 | Adipose | gene expression | ENSRNOG00000050169 | 0.9500 | 0.01900 | 0.0e+00 | 0.312 | 0.269 | 0.341 | 0.314 | 3.4e-35 | 7.5e-30 | 3.9e-39 | 1.9e-35 |
4 | Adipose | isoform ratio | ENSRNOT00000071928 | 0.2300 | 0.09600 | 3.9e-16 | 0.107 | 0.115 | 0.132 | 0.131 | 7.4e-12 | 1.0e-12 | 1.8e-14 | 2.6e-14 |
5 | Adipose | isoform ratio | ENSRNOT00000107172 | 0.2300 | 0.09600 | 5.0e-16 | 0.087 | 0.113 | 0.131 | 0.129 | 6.2e-10 | 1.6e-12 | 2.6e-14 | 3.7e-14 |
6 | BLA | alternative TSS | ENSRNOT00000110166 | 0.1073 | 0.06710 | 2.9e-03 | 0.054 | 0.053 | 0.051 | 0.049 | 7.7e-04 | 8.4e-04 | 1.0e-03 | 1.2e-03 |
7 | BLA | gene expression | ENSRNOG00000050169 | 0.4958 | 0.10989 | 0.0e+00 | 0.410 | 0.423 | 0.438 | 0.440 | 1.6e-23 | 2.1e-24 | 1.5e-25 | 1.2e-25 |
8 | BLA | isoform ratio | ENSRNOT00000071928 | 0.1100 | 0.06300 | 8.8e-05 | 0.110 | 0.087 | 0.101 | 0.111 | 1.7e-06 | 2.2e-05 | 4.6e-06 | 1.6e-06 |
9 | BLA | intron excision ratio | chr12:1679962:1680708 | 0.2600 | 0.11000 | 9.8e-06 | 0.095 | 0.090 | 0.099 | 0.096 | 9.4e-06 | 1.5e-05 | 6.0e-06 | 7.8e-06 |
10 | BLA | intron excision ratio | chr12:1680171:1680708 | 0.1800 | 0.09400 | 3.8e-04 | 0.059 | 0.063 | 0.063 | 0.069 | 4.4e-04 | 2.8e-04 | 2.9e-04 | 1.5e-04 |
11 | BLA | intron excision ratio | chr12:1680794:1680963 | 0.3600 | 0.12000 | 2.8e-10 | 0.117 | 0.187 | 0.187 | 0.191 | 8.0e-07 | 2.7e-10 | 2.9e-10 | 1.7e-10 |
12 | BLA | intron excision ratio | chr12:1680995:1681508 | 0.3500 | 0.12000 | 6.2e-10 | 0.124 | 0.174 | 0.181 | 0.196 | 3.9e-07 | 1.4e-09 | 5.5e-10 | 9.8e-11 |
13 | Brain | alternative TSS | ENSRNOT00000110166 | 0.0423 | 0.03132 | 5.4e-03 | 0.007 | 0.011 | 0.026 | 0.015 | 6.9e-02 | 2.8e-02 | 1.7e-03 | 1.3e-02 |
14 | Brain | gene expression | ENSRNOG00000050169 | 0.6400 | 0.11000 | 0.0e+00 | 0.592 | 0.602 | 0.608 | 0.606 | 7.8e-68 | 1.4e-69 | 8.7e-71 | 2.2e-70 |
15 | Brain | isoform ratio | ENSRNOT00000071928 | 0.1593 | 0.07939 | 4.4e-10 | 0.126 | 0.127 | 0.122 | 0.132 | 1.1e-11 | 8.0e-12 | 2.3e-11 | 3.1e-12 |
16 | Brain | intron excision ratio | chr12:1679962:1680708 | 0.2761 | 0.11028 | 1.6e-09 | 0.085 | 0.108 | 0.112 | 0.113 | 2.8e-08 | 3.4e-10 | 1.5e-10 | 1.4e-10 |
17 | Brain | intron excision ratio | chr12:1680171:1680708 | 0.2290 | 0.10043 | 6.0e-07 | 0.056 | 0.091 | 0.086 | 0.079 | 6.0e-06 | 9.3e-09 | 2.2e-08 | 8.5e-08 |
18 | Brain | intron excision ratio | chr12:1680794:1680963 | 0.0846 | 0.04814 | 1.4e-04 | 0.053 | 0.048 | 0.044 | 0.044 | 1.1e-05 | 2.7e-05 | 6.0e-05 | 5.7e-05 |
19 | Brain | intron excision ratio | chr12:1680995:1681508 | 0.0646 | 0.03993 | 1.1e-03 | 0.041 | 0.034 | 0.025 | 0.030 | 1.0e-04 | 3.5e-04 | 2.0e-03 | 7.6e-04 |
20 | Eye | gene expression | ENSRNOG00000050169 | 0.6600 | 0.15000 | 4.5e-04 | 0.031 | 0.200 | 0.156 | 0.147 | 1.1e-01 | 5.3e-04 | 2.2e-03 | 2.9e-03 |
21 | IL | gene expression | ENSRNOG00000050169 | 0.6430 | 0.13100 | 3.7e-09 | 0.249 | 0.269 | 0.234 | 0.270 | 1.1e-06 | 3.5e-07 | 2.5e-06 | 3.4e-07 |
22 | LHb | gene expression | ENSRNOG00000050169 | 0.7591 | 0.14550 | 6.9e-09 | 0.329 | 0.282 | 0.239 | 0.267 | 1.3e-08 | 2.1e-07 | 2.2e-06 | 4.8e-07 |
23 | Liver | gene expression | ENSRNOG00000050169 | 0.5900 | 0.13000 | 0.0e+00 | 0.140 | 0.180 | 0.178 | 0.185 | 2.4e-15 | 1.6e-19 | 2.7e-19 | 4.4e-20 |
24 | Liver | intron excision ratio | chr12:1680794:1680963 | 0.2076 | 0.08691 | 1.1e-12 | 0.044 | 0.093 | 0.081 | 0.089 | 1.1e-05 | 1.9e-10 | 2.4e-09 | 3.8e-10 |
25 | Liver | intron excision ratio | chr12:1680995:1681508 | 0.1820 | 0.08110 | 9.8e-10 | 0.045 | 0.066 | 0.070 | 0.069 | 8.4e-06 | 8.1e-08 | 3.1e-08 | 4.0e-08 |
26 | NAcc | alternative TSS | ENSRNOT00000071928 | 0.0770 | 0.04500 | 2.9e-03 | 0.034 | 0.021 | 0.027 | 0.030 | 1.4e-03 | 1.0e-02 | 4.3e-03 | 2.6e-03 |
27 | NAcc | gene expression | ENSRNOG00000050169 | 0.4100 | 0.05000 | 0.0e+00 | 0.403 | 0.493 | 0.494 | 0.500 | 5.9e-32 | 1.7e-41 | 1.5e-41 | 2.8e-42 |
28 | OFC | gene expression | ENSRNOG00000050169 | 0.6813 | 0.12490 | 3.8e-11 | 0.293 | 0.290 | 0.281 | 0.312 | 1.1e-07 | 1.3e-07 | 2.1e-07 | 3.6e-08 |
29 | PL | gene expression | ENSRNOG00000050169 | 0.3798 | 0.03645 | 0.0e+00 | 0.541 | 0.581 | 0.588 | 0.590 | 2.4e-48 | 1.1e-53 | 1.0e-54 | 4.5e-55 |
30 | PL | intron excision ratio | chr12:1679962:1680708 | 0.0847 | 0.05744 | 8.7e-03 | 0.027 | 0.021 | 0.013 | 0.021 | 3.6e-03 | 9.2e-03 | 3.0e-02 | 9.3e-03 |
31 | PL | intron excision ratio | chr12:1680171:1680708 | 0.0901 | 0.05817 | 7.4e-03 | 0.034 | 0.018 | 0.027 | 0.024 | 1.3e-03 | 1.6e-02 | 3.5e-03 | 5.8e-03 |
32 | PL | intron excision ratio | chr12:1680794:1680963 | 0.4871 | 0.00658 | 2.1e-13 | 0.130 | 0.175 | 0.173 | 0.174 | 4.5e-10 | 2.5e-13 | 3.7e-13 | 3.2e-13 |
33 | PL | intron excision ratio | chr12:1680995:1681508 | 0.3751 | 0.19812 | 6.1e-12 | 0.130 | 0.159 | 0.162 | 0.164 | 4.2e-10 | 3.6e-12 | 2.4e-12 | 1.8e-12 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Length with tail | 11.9 | 43.6 | 79.4 | 8.8 | -8.8 | 3.4 | 8.9 | -8.9 | -8.2 | 2.8 | 1.8 | -6.3 | 6.4 | -8.9 | 8.8 | -6.5 | 0.5 | 1.8 | -5.5 | 3.7 | -7.5 | 7.5 | -5.0 | 6.5 | 1.8 | -1.6 | -8.6 | 7.5 | 8.7 | 4.6 | 5.2 | 3.6 | -8.0 | 7.7 | -8.6 | 7.6 |
Body weight | 10.6 | 45.0 | 89.9 | 9.0 | -9.0 | 4.0 | 9.1 | -9.1 | -7.6 | 3.5 | 3.0 | -5.1 | 5.4 | -9.5 | 9.5 | -5.4 | 1.8 | 3.0 | -4.3 | 2.1 | -8.1 | 8.1 | -4.8 | 7.6 | 3.1 | -0.7 | -8.5 | 7.9 | 9.2 | 5.5 | 5.9 | 4.5 | -7.3 | 7.2 | -8.2 | 7.9 |
Length without tail | 7.4 | 16.1 | 32.1 | 5.6 | -5.6 | 2.6 | 5.7 | -5.6 | -4.4 | 2.1 | 2.0 | -2.9 | 3.1 | -5.5 | 5.5 | -3.2 | 1.0 | 2.0 | -2.5 | 1.1 | -4.8 | 4.8 | -3.1 | 4.6 | 1.7 | -0.3 | -5.1 | 4.8 | 5.7 | 3.2 | 3.4 | 2.6 | -4.3 | 4.0 | -4.8 | 4.7 |
Left kidney weight | 6.8 | 19.6 | 36.2 | 5.5 | -5.5 | 1.2 | 5.5 | -5.6 | -5.9 | 1.0 | 0.2 | -5.0 | 5.0 | -5.8 | 5.6 | -4.9 | -0.8 | 0.2 | -4.7 | 3.7 | -4.6 | 4.6 | -4.1 | 3.6 | 0.0 | -2.0 | -5.8 | 4.8 | 5.9 | 2.3 | 2.7 | 1.5 | -5.9 | 5.8 | -6.0 | 4.8 |
Tail length | 6.0 | 18.0 | 32.9 | 5.4 | -5.3 | 2.1 | 5.4 | -5.4 | -5.3 | 2.1 | 1.3 | -4.2 | 4.1 | -5.7 | 5.6 | -4.2 | 0.6 | 1.3 | -3.5 | 2.6 | -5.0 | 5.0 | -2.7 | 4.1 | 1.4 | -0.7 | -5.7 | 4.9 | 5.2 | 3.2 | 3.7 | 2.7 | -5.2 | 5.1 | -5.7 | 5.1 |
Right kidney weight | 5.7 | 16.2 | 30.9 | 5.1 | -5.1 | 1.4 | 5.2 | -5.2 | -5.3 | 1.0 | 0.5 | -4.2 | 4.3 | -5.5 | 5.4 | -4.4 | -0.3 | 0.5 | -3.8 | 2.8 | -4.4 | 4.4 | -3.6 | 3.6 | 0.5 | -1.6 | -5.2 | 4.3 | 5.6 | 2.3 | 2.6 | 1.6 | -5.1 | 5.1 | -5.3 | 4.3 |
Tibialis anterior weight | 5.4 | 18.6 | 33.7 | 5.6 | -5.6 | 2.7 | 5.6 | -5.6 | -4.9 | 2.5 | 1.9 | -3.5 | 3.5 | -5.8 | 5.8 | -3.8 | 1.1 | 1.9 | -3.0 | 2.0 | -5.0 | 5.0 | -3.1 | 4.5 | 1.8 | -0.3 | -5.8 | 5.7 | 5.3 | 3.6 | 4.0 | 3.1 | -4.9 | 4.8 | -5.5 | 5.3 |
Bone: connectivity density | 4.9 | 7.6 | 18.3 | 3.3 | -3.3 | -0.3 | 3.4 | -3.4 | -3.7 | -0.3 | -0.6 | -3.3 | 3.4 | -3.5 | 3.4 | -4.3 | -0.9 | -0.6 | -3.2 | 2.3 | -2.6 | 2.6 | -3.6 | 1.7 | -0.4 | -2.0 | -3.3 | 3.3 | 3.6 | 0.7 | 1.0 | 0.2 | -3.5 | 3.6 | -3.3 | 2.3 |
Social response proportion | 4.7 | 5.1 | 10.3 | 2.5 | -2.5 | 2.3 | 2.6 | -2.5 | -1.9 | 2.3 | 1.8 | -1.4 | 1.1 | -2.9 | 3.0 | -0.3 | 1.2 | 1.8 | -1.0 | 0.7 | -3.0 | 3.0 | 0.3 | 2.7 | 1.5 | 0.9 | -3.0 | 2.4 | 2.3 | 2.6 | 2.8 | 2.4 | -2.2 | 2.3 | -3.0 | 3.2 |
Delay discounting water rate 0 sec | 4.1 | 6.6 | 18.0 | 1.1 | -1.1 | -2.6 | 1.1 | -1.1 | -2.7 | -2.4 | -3.3 | -4.0 | 3.8 | -1.1 | 0.7 | -3.9 | -3.3 | -3.3 | -4.0 | 4.2 | 0.1 | -0.1 | -3.7 | -1.4 | -3.2 | -3.6 | -1.6 | 1.1 | 1.3 | -1.8 | -1.4 | -2.4 | -3.0 | 3.1 | -2.2 | 0.1 |
Extensor digitorum longus weight | 3.9 | 15.5 | 28.4 | 5.1 | -5.1 | 1.9 | 5.2 | -5.2 | -4.9 | 1.7 | 1.0 | -3.8 | 3.9 | -5.2 | 5.1 | -4.0 | 0.5 | 1.0 | -3.4 | 2.5 | -4.3 | 4.3 | -3.4 | 3.6 | 1.1 | -0.9 | -5.3 | 5.2 | 4.8 | 2.8 | 3.2 | 2.2 | -4.8 | 4.8 | -5.2 | 4.5 |
Bone surface | 3.7 | 6.5 | 13.3 | 3.5 | -3.6 | 0.6 | 3.6 | -3.6 | -3.0 | 0.3 | 0.2 | -2.3 | 2.5 | -3.4 | 3.4 | -3.5 | -0.2 | 0.2 | -2.3 | 1.3 | -2.6 | 2.6 | -3.2 | 2.2 | 0.3 | -1.3 | -3.0 | 3.4 | 3.6 | 1.1 | 1.3 | 0.8 | -2.9 | 3.0 | -2.9 | 2.3 |
Bone: trabecular thickness | 3.7 | 4.4 | 9.9 | 2.7 | -2.8 | 0.3 | 2.8 | -2.8 | -2.6 | 0.3 | 0.1 | -2.1 | 2.2 | -2.7 | 2.7 | -3.0 | -0.1 | 0.1 | -2.0 | 1.4 | -2.2 | 2.2 | -2.7 | 1.6 | 0.2 | -1.1 | -2.6 | 3.1 | 2.8 | 1.0 | 1.1 | 0.6 | -2.5 | 2.4 | -2.5 | 2.0 |
Delay disc. indifference point, 2s delay | 3.7 | 4.2 | 13.3 | -1.4 | 1.4 | 1.7 | -1.4 | 1.4 | 1.9 | 2.5 | 2.8 | 2.8 | -2.8 | 0.7 | -0.5 | 3.6 | 2.8 | 2.8 | 2.8 | -2.6 | -0.3 | 0.3 | 2.8 | 1.2 | 2.5 | 3.2 | 0.6 | 0.4 | -1.4 | 1.8 | 1.6 | 2.3 | 1.9 | -2.0 | 1.2 | 0.6 |
Median of all reaction times | 3.6 | 4.9 | 15.7 | -1.9 | 1.9 | 1.6 | -1.8 | 1.9 | 2.8 | 1.3 | 1.8 | 3.3 | -3.3 | 2.0 | -1.8 | 4.0 | 2.0 | 1.8 | 3.1 | -2.9 | 1.0 | -1.0 | 3.4 | -0.1 | 1.7 | 2.7 | 2.1 | -1.6 | -2.3 | 0.6 | 0.4 | 1.1 | 3.0 | -3.1 | 2.4 | -1.0 |
Delay disc. indifference point, 0s delay | 3.5 | 3.8 | 9.3 | 0.6 | -0.6 | 2.5 | 0.5 | -0.5 | 0.3 | 2.7 | 3.0 | 1.6 | -1.5 | -1.1 | 1.3 | 2.1 | 2.7 | 3.0 | 1.8 | -2.5 | -1.7 | 1.7 | 2.2 | 2.6 | 2.9 | 2.6 | -0.8 | 1.2 | 0.6 | 2.6 | 2.5 | 2.9 | 0.6 | -0.6 | -0.3 | 1.9 |
Conditioned reinforcement - actives | 3.3 | 3.3 | 7.9 | 2.2 | -2.1 | 0.5 | 2.1 | -2.1 | -2.5 | 0.4 | -0.2 | -2.4 | 2.3 | -2.1 | 1.9 | -2.1 | -0.5 | -0.2 | -2.1 | 1.9 | -1.9 | 1.9 | -1.2 | 1.2 | -0.1 | -0.9 | -2.5 | 1.7 | 1.5 | 0.9 | 1.2 | 0.6 | -2.7 | 2.8 | -2.7 | 2.0 |
Bone: apparent density | 3.3 | 5.5 | 16.3 | 2.8 | -2.9 | -0.7 | 2.9 | -2.9 | -2.9 | -0.9 | -1.1 | -2.8 | 3.0 | -2.7 | 2.6 | -4.0 | -1.3 | -1.1 | -2.8 | 2.1 | -1.7 | 1.7 | -3.9 | 1.0 | -0.9 | -2.3 | -2.4 | 2.8 | 3.1 | -0.1 | 0.2 | -0.5 | -2.8 | 2.9 | -2.4 | 1.3 |
Post-drug Anxiety | 3.2 | 3.5 | 10.7 | -2.0 | 2.1 | 0.7 | -2.0 | 2.0 | 2.5 | 1.3 | 1.5 | 2.6 | -2.8 | 1.5 | -1.4 | 3.3 | 1.9 | 1.5 | 2.8 | -2.3 | 0.5 | -0.5 | 2.6 | -0.1 | 1.5 | 2.4 | 1.5 | -0.9 | -2.1 | 0.7 | 0.4 | 1.0 | 2.5 | -2.3 | 1.9 | -0.6 |
Baseline Anxiety | 3.2 | 3.4 | 9.0 | -1.6 | 1.6 | 1.4 | -1.6 | 1.6 | 2.6 | 1.1 | 1.6 | 2.9 | -2.9 | 1.3 | -1.1 | 3.0 | 1.8 | 1.6 | 2.9 | -2.7 | 0.4 | -0.4 | 2.7 | 0.2 | 1.6 | 2.2 | 1.7 | -1.6 | -1.5 | 0.6 | 0.4 | 0.9 | 2.5 | -2.5 | 2.0 | -0.7 |
Tibia length | 3.1 | 8.7 | 20.5 | 4.5 | -4.5 | 2.2 | 4.4 | -4.4 | -3.1 | 1.3 | 1.2 | -2.3 | 2.3 | -4.2 | 4.2 | -3.0 | 0.1 | 1.2 | -2.0 | 0.8 | -3.1 | 3.1 | -1.8 | 3.4 | 0.9 | -0.5 | -3.5 | 2.2 | 4.4 | 2.1 | 2.3 | 1.9 | -3.2 | 3.4 | -3.6 | 3.3 |
Delay discounting time to switch 0 sec | 3.1 | 4.7 | 15.2 | -0.5 | 0.5 | 2.3 | -0.6 | 0.6 | 2.6 | 1.8 | 2.8 | 3.6 | -3.4 | 0.6 | -0.3 | 3.3 | 2.7 | 2.8 | 3.4 | -3.9 | 0.1 | -0.1 | 2.7 | 1.4 | 2.7 | 2.9 | 1.4 | -0.8 | -0.5 | 1.4 | 1.1 | 1.9 | 2.6 | -2.6 | 1.9 | -0.2 |
Progressive ratio test 2 inactive lever presses | 3.1 | 3.6 | 9.9 | 1.0 | -1.0 | -1.6 | 0.9 | -0.9 | -2.3 | -1.6 | -2.3 | -3.0 | 3.0 | -0.6 | 0.5 | -2.9 | -2.3 | -2.3 | -3.1 | 3.1 | 0.0 | -0.0 | -2.4 | -0.9 | -2.2 | -2.6 | -1.3 | 1.0 | 0.5 | -1.2 | -0.8 | -1.5 | -2.5 | 2.6 | -1.8 | 0.2 |
Context. condit. distance diff. score | 3.1 | 3.8 | 10.3 | 2.2 | -2.2 | 1.2 | 2.3 | -2.3 | -2.1 | 1.4 | 1.0 | -1.6 | 1.5 | -2.5 | 2.5 | -1.4 | 1.0 | 1.0 | -1.1 | 1.0 | -2.5 | 2.5 | -1.2 | 1.9 | 1.0 | 0.2 | -2.7 | 3.2 | 2.0 | 1.9 | 2.0 | 1.6 | -2.1 | 2.1 | -2.5 | 2.5 |
Bone: trabecular number | 3.1 | 4.9 | 10.8 | 2.9 | -2.9 | 0.1 | 2.9 | -2.9 | -2.8 | -0.1 | -0.3 | -2.4 | 2.6 | -2.9 | 2.8 | -3.3 | -0.6 | -0.3 | -2.3 | 1.6 | -2.1 | 2.1 | -2.9 | 1.5 | -0.2 | -1.5 | -2.5 | 2.8 | 3.0 | 0.7 | 0.9 | 0.3 | -2.7 | 2.7 | -2.5 | 1.8 |
BMI without tail | 3.0 | 6.3 | 13.2 | 3.0 | -3.0 | 1.8 | 3.1 | -3.1 | -2.7 | 2.0 | 1.6 | -1.6 | 1.7 | -3.5 | 3.6 | -1.4 | 1.3 | 1.6 | -1.2 | 0.6 | -3.2 | 3.2 | -0.8 | 3.0 | 1.8 | 0.4 | -3.2 | 3.0 | 3.0 | 2.5 | 2.8 | 2.3 | -2.4 | 2.6 | -3.1 | 3.3 |
Reaction time mean | 3.0 | 4.1 | 14.3 | -1.4 | 1.4 | 2.1 | -1.3 | 1.4 | 2.3 | 1.9 | 2.2 | 2.9 | -2.9 | 1.3 | -1.1 | 3.8 | 2.4 | 2.2 | 2.7 | -2.6 | 0.3 | -0.3 | 3.3 | 0.5 | 2.1 | 2.9 | 1.3 | -0.7 | -1.8 | 1.2 | 1.1 | 1.7 | 2.4 | -2.5 | 1.7 | -0.2 |
Bone: elastic work | 3.0 | 3.8 | 7.8 | 2.6 | -2.7 | 0.3 | 2.7 | -2.7 | -2.5 | -0.0 | -0.3 | -2.3 | 2.3 | -2.4 | 2.3 | -2.8 | -0.6 | -0.3 | -2.2 | 1.7 | -1.7 | 1.7 | -2.3 | 1.3 | -0.3 | -1.3 | -2.4 | 2.1 | 2.5 | 0.6 | 0.8 | 0.3 | -2.6 | 2.6 | -2.5 | 1.7 |
Reaction time mean AUC | 2.9 | 3.8 | 13.9 | -1.5 | 1.5 | 1.9 | -1.4 | 1.5 | 2.3 | 1.7 | 2.0 | 2.9 | -2.8 | 1.5 | -1.3 | 3.7 | 2.2 | 2.0 | 2.6 | -2.5 | 0.4 | -0.4 | 3.1 | 0.3 | 1.8 | 2.7 | 1.3 | -0.7 | -1.9 | 1.0 | 0.9 | 1.5 | 2.4 | -2.5 | 1.7 | -0.3 |
Cd content in liver | 2.9 | 3.2 | 6.7 | -2.1 | 2.2 | -2.0 | -2.2 | 2.1 | 0.7 | -1.9 | -2.2 | -0.3 | 0.2 | 2.1 | -2.2 | 0.6 | -1.6 | -2.2 | -0.4 | 1.2 | 2.2 | -2.2 | 0.0 | -2.6 | -2.0 | -1.2 | 1.7 | -2.1 | -2.1 | -2.2 | -2.0 | -2.2 | 0.7 | -0.6 | 1.3 | -2.1 |
Bone: trabecular tissue density | 2.8 | 3.9 | 9.5 | 0.4 | -0.4 | 2.9 | 0.5 | -0.4 | 0.5 | 3.1 | 2.9 | 1.2 | -1.5 | -0.8 | 0.9 | 2.6 | 3.0 | 2.9 | 1.7 | -1.5 | -1.8 | 1.8 | 2.6 | 2.1 | 2.9 | 2.9 | -1.1 | 1.5 | -0.2 | 2.8 | 2.8 | 2.9 | 0.3 | -0.4 | -0.7 | 2.1 |
Liver weight, right | 2.6 | 4.3 | 8.4 | 2.3 | -2.4 | -0.4 | 2.4 | -2.4 | -2.9 | -0.1 | -0.5 | -2.6 | 2.7 | -2.6 | 2.5 | -2.4 | -0.8 | -0.5 | -2.6 | 2.0 | -1.8 | 1.8 | -2.7 | 1.3 | -0.4 | -1.5 | -2.5 | 2.5 | 2.7 | 0.5 | 0.8 | 0.2 | -2.9 | 2.8 | -2.6 | 1.8 |
Compulsive drug intake | 2.6 | 2.6 | 4.7 | -2.1 | 2.1 | -1.2 | -2.1 | 2.0 | 1.8 | -1.0 | -0.8 | 1.3 | -1.3 | 2.2 | -2.1 | 1.5 | -0.5 | -0.8 | 1.0 | -0.6 | 1.8 | -1.8 | 1.1 | -1.8 | -0.8 | 0.1 | 2.1 | -1.9 | -2.0 | -1.4 | -1.5 | -1.2 | 1.8 | -1.8 | 2.0 | -2.0 |
Bone: trabecular spacing | 2.5 | 3.3 | 6.2 | -2.3 | 2.3 | -0.6 | -2.4 | 2.4 | 2.3 | -0.5 | -0.2 | 1.9 | -1.9 | 2.5 | -2.5 | 2.1 | 0.0 | -0.2 | 1.7 | -1.2 | 2.0 | -2.0 | 1.6 | -1.5 | -0.3 | 0.7 | 2.3 | -2.1 | -2.3 | -1.0 | -1.2 | -0.8 | 2.2 | -2.5 | 2.3 | -1.9 |
Reaction time mean minus median | 2.4 | 3.1 | 8.0 | 0.2 | -0.2 | 2.6 | 0.4 | -0.3 | -0.1 | 2.8 | 2.5 | 0.8 | -0.9 | -0.9 | 1.0 | 2.0 | 2.5 | 2.5 | 1.1 | -1.0 | -2.0 | 2.0 | 1.7 | 1.9 | 2.3 | 2.5 | -1.4 | 2.1 | 0.0 | 2.6 | 2.6 | 2.7 | -0.0 | -0.2 | -0.9 | 2.0 |
Delay discount hyperbolic model param | 2.4 | 2.5 | 9.7 | 1.1 | -1.1 | -1.6 | 1.0 | -1.1 | -1.3 | -2.1 | -2.2 | -2.1 | 2.1 | -0.6 | 0.4 | -3.1 | -2.1 | -2.2 | -2.0 | 1.7 | 0.4 | -0.4 | -2.4 | -0.9 | -1.9 | -2.5 | -0.3 | -0.2 | 1.2 | -1.5 | -1.4 | -1.9 | -1.3 | 1.5 | -0.7 | -0.6 |
Zn content in liver | 2.4 | 2.7 | 7.0 | 2.0 | -2.0 | -0.4 | 2.0 | -2.0 | -2.1 | -0.9 | -1.0 | -1.9 | 2.2 | -1.8 | 1.7 | -2.6 | -1.4 | -1.0 | -2.2 | 1.7 | -0.8 | 0.8 | -2.5 | 0.5 | -1.0 | -1.9 | -1.5 | 1.2 | 2.2 | -0.3 | -0.1 | -0.6 | -2.1 | 2.0 | -1.7 | 0.8 |
Bone: cortical area | 2.3 | 3.6 | 6.5 | 2.5 | -2.4 | 2.1 | 2.5 | -2.5 | -1.7 | 1.7 | 1.6 | -0.8 | 0.8 | -2.3 | 2.4 | -0.8 | 1.3 | 1.6 | -0.5 | 0.0 | -2.3 | 2.3 | -0.5 | 2.3 | 1.5 | 0.8 | -2.3 | 2.5 | 2.0 | 2.1 | 2.2 | 1.9 | -1.5 | 1.5 | -2.0 | 2.4 |
Bone: final force | 2.3 | 3.8 | 7.8 | 2.8 | -2.8 | 1.7 | 2.8 | -2.8 | -2.2 | 1.2 | 0.9 | -1.6 | 1.5 | -2.6 | 2.6 | -1.7 | 0.4 | 0.9 | -1.4 | 0.8 | -2.2 | 2.2 | -0.9 | 2.1 | 0.8 | -0.0 | -2.5 | 1.9 | 2.4 | 1.7 | 1.7 | 1.4 | -2.2 | 2.2 | -2.5 | 2.4 |
Area under the delay curve | 2.3 | 2.5 | 8.3 | -0.9 | 0.9 | 1.7 | -0.8 | 0.8 | 1.1 | 2.2 | 2.3 | 1.9 | -1.9 | 0.3 | -0.2 | 2.9 | 2.2 | 2.3 | 1.9 | -1.7 | -0.6 | 0.6 | 2.4 | 1.1 | 2.0 | 2.5 | 0.1 | 0.3 | -1.0 | 1.6 | 1.6 | 2.0 | 1.1 | -1.4 | 0.5 | 0.9 |
Delay discount exponential model param | 2.3 | 2.4 | 9.0 | 1.1 | -1.1 | -1.6 | 1.0 | -1.0 | -1.2 | -2.1 | -2.1 | -1.9 | 1.9 | -0.5 | 0.4 | -3.0 | -2.1 | -2.1 | -1.9 | 1.6 | 0.5 | -0.5 | -2.4 | -0.9 | -1.9 | -2.4 | -0.2 | -0.3 | 1.2 | -1.5 | -1.5 | -1.9 | -1.2 | 1.4 | -0.6 | -0.7 |
Seeking ratio, delayed vs. immediate footshock | 2.3 | 2.6 | 5.6 | -1.8 | 1.8 | -1.6 | -1.9 | 1.9 | 1.5 | -1.6 | -1.3 | 0.8 | -0.8 | 2.0 | -2.0 | 0.2 | -1.1 | -1.3 | 0.6 | -0.4 | 2.2 | -2.2 | 0.4 | -1.9 | -1.2 | -0.6 | 2.1 | -2.4 | -1.5 | -1.9 | -2.0 | -1.7 | 1.4 | -1.2 | 1.9 | -2.3 |
Saline control response | 2.2 | 3.0 | 7.9 | 1.3 | -1.3 | -1.0 | 1.4 | -1.4 | -2.6 | -0.7 | -1.3 | -2.8 | 2.8 | -1.4 | 1.2 | -2.8 | -1.6 | -1.3 | -2.8 | 2.7 | -0.8 | 0.8 | -1.9 | -0.0 | -1.4 | -1.9 | -1.8 | 0.9 | 1.4 | -0.3 | -0.0 | -0.6 | -2.5 | 2.5 | -2.2 | 1.0 |
Bone volume | 2.2 | 3.7 | 9.9 | 2.7 | -2.8 | 0.0 | 2.8 | -2.8 | -2.2 | -0.4 | -0.3 | -1.8 | 2.0 | -2.4 | 2.4 | -3.1 | -0.6 | -0.3 | -1.9 | 1.1 | -1.5 | 1.5 | -3.1 | 1.3 | -0.2 | -1.5 | -2.0 | 2.8 | 2.8 | 0.3 | 0.4 | 0.1 | -2.1 | 2.1 | -1.9 | 1.3 |
Water consumed over 24 hours | 2.1 | 2.4 | 5.5 | 1.9 | -1.9 | 0.0 | 1.9 | -1.9 | -2.2 | -0.6 | -0.9 | -2.3 | 2.3 | -1.6 | 1.5 | -2.3 | -1.1 | -0.9 | -2.2 | 1.8 | -0.9 | 0.9 | -1.6 | 0.5 | -0.8 | -1.6 | -1.7 | 0.7 | 1.9 | 0.0 | 0.2 | -0.4 | -2.2 | 2.2 | -1.9 | 1.0 |
Food seeking constrained by brief footshock | 2.1 | 2.5 | 5.4 | -1.2 | 1.2 | -2.3 | -1.4 | 1.3 | 0.9 | -2.1 | -1.9 | 0.1 | -0.0 | 1.4 | -1.4 | -0.7 | -1.8 | -1.9 | -0.3 | 0.3 | 2.3 | -2.3 | -1.0 | -2.0 | -1.9 | -1.5 | 1.7 | -1.4 | -0.8 | -2.2 | -2.3 | -2.2 | 0.9 | -0.7 | 1.5 | -2.3 |
BMI with tail | 2.0 | 6.5 | 13.5 | 2.9 | -2.9 | 2.3 | 2.9 | -2.9 | -1.9 | 2.5 | 2.6 | -0.3 | 0.6 | -3.5 | 3.7 | -0.2 | 2.3 | 2.6 | 0.0 | -1.0 | -3.2 | 3.2 | -0.6 | 3.7 | 2.7 | 1.3 | -2.8 | 3.3 | 3.2 | 3.0 | 3.0 | 2.8 | -1.5 | 1.7 | -2.3 | 3.2 |
Delay discounting total patch changes 24 sec | 2.0 | 2.6 | 6.3 | -0.8 | 0.8 | -2.5 | -0.7 | 0.7 | -0.6 | -2.1 | -2.5 | -1.5 | 1.5 | 0.9 | -1.1 | -1.8 | -2.1 | -2.5 | -1.8 | 2.2 | 1.4 | -1.4 | -2.0 | -2.0 | -2.3 | -2.1 | 0.4 | -0.0 | -0.5 | -2.1 | -1.9 | -2.2 | -0.8 | 0.5 | 0.1 | -1.2 |
Conditioned locomotion | 2.0 | 2.4 | 6.4 | 1.7 | -1.6 | -0.1 | 1.6 | -1.6 | -2.1 | 0.2 | -0.5 | -2.3 | 2.1 | -1.5 | 1.4 | -2.2 | -0.6 | -0.5 | -2.0 | 2.0 | -1.4 | 1.4 | -1.5 | 0.7 | -0.4 | -1.0 | -2.1 | 1.8 | 1.1 | 0.5 | 0.8 | 0.3 | -2.3 | 2.5 | -2.2 | 1.6 |
Bone: cortical thickness | 2.0 | 3.2 | 6.0 | 2.4 | -2.4 | 2.0 | 2.4 | -2.4 | -1.7 | 1.6 | 1.5 | -0.8 | 0.9 | -2.3 | 2.3 | -1.0 | 1.1 | 1.5 | -0.5 | 0.1 | -2.1 | 2.1 | -0.5 | 2.2 | 1.4 | 0.7 | -2.2 | 2.5 | 2.0 | 2.0 | 2.0 | 1.8 | -1.5 | 1.4 | -2.0 | 2.3 |
Total heroin consumption | 2.0 | 2.4 | 6.9 | -2.3 | 2.2 | -0.1 | -2.2 | 2.2 | 1.8 | 0.7 | 0.8 | 1.9 | -1.9 | 1.9 | -1.8 | 2.6 | 1.3 | 0.8 | 1.8 | -1.3 | 1.0 | -1.0 | 2.0 | -0.8 | 0.8 | 1.8 | 1.4 | -0.5 | -2.5 | 0.1 | -0.0 | 0.3 | 1.8 | -2.0 | 1.7 | -0.9 |
Se content in liver | 2.0 | 2.4 | 8.8 | 1.1 | -1.1 | 1.6 | 1.2 | -1.2 | -0.5 | 2.0 | 2.0 | 0.3 | -0.4 | -1.5 | 1.7 | 0.7 | 2.2 | 2.0 | 0.7 | -1.0 | -2.1 | 2.1 | 0.2 | 2.0 | 2.1 | 1.6 | -1.5 | 3.0 | 1.0 | 2.1 | 2.1 | 2.0 | -0.4 | 0.2 | -1.0 | 1.8 |
Pavlov. Cond. magazine entry latency | 1.9 | 2.2 | 7.0 | -0.9 | 0.9 | 1.7 | -0.8 | 0.9 | 1.5 | 1.7 | 1.8 | 1.9 | -2.0 | 0.7 | -0.6 | 2.7 | 2.0 | 1.8 | 2.1 | -1.7 | -0.4 | 0.4 | 2.3 | 0.5 | 1.8 | 2.3 | 0.6 | 0.0 | -1.4 | 1.3 | 1.1 | 1.4 | 1.6 | -1.5 | 0.9 | 0.3 |
Pavlov. Cond. lever latency | 1.9 | 2.4 | 5.9 | 2.1 | -2.1 | 0.1 | 2.1 | -2.1 | -2.0 | -0.2 | -0.4 | -1.9 | 1.9 | -1.9 | 1.7 | -2.4 | -0.7 | -0.4 | -1.8 | 1.3 | -1.6 | 1.6 | -1.8 | 1.0 | -0.3 | -1.3 | -1.7 | 0.8 | 2.2 | 0.4 | 0.4 | 0.1 | -2.0 | 2.0 | -1.9 | 1.3 |
Bone: final moment | 1.9 | 3.2 | 6.8 | 2.6 | -2.6 | 1.5 | 2.6 | -2.6 | -2.0 | 0.9 | 0.7 | -1.5 | 1.5 | -2.4 | 2.4 | -1.6 | 0.3 | 0.7 | -1.3 | 0.8 | -2.0 | 2.0 | -0.9 | 1.8 | 0.7 | -0.2 | -2.2 | 1.6 | 2.2 | 1.4 | 1.5 | 1.2 | -2.0 | 2.0 | -2.2 | 2.1 |
Bone: maximum force | 1.9 | 3.2 | 6.4 | 2.5 | -2.5 | 0.9 | 2.5 | -2.5 | -2.3 | 0.5 | 0.2 | -1.9 | 1.9 | -2.3 | 2.3 | -2.1 | -0.2 | 0.2 | -1.8 | 1.3 | -1.8 | 1.8 | -1.6 | 1.5 | 0.1 | -0.6 | -2.3 | 2.0 | 2.2 | 1.0 | 1.1 | 0.8 | -2.2 | 2.3 | -2.3 | 1.9 |
Delta time in open arm before/after self-admin | 1.9 | 1.8 | 4.0 | -1.5 | 1.5 | -0.4 | -1.6 | 1.6 | 1.7 | -0.2 | 0.3 | 1.8 | -1.7 | 1.6 | -1.5 | 2.0 | 0.5 | 0.3 | 1.6 | -1.5 | 1.3 | -1.3 | 0.9 | -0.8 | 0.2 | 0.8 | 1.7 | -1.2 | -1.5 | -0.5 | -0.8 | -0.4 | 1.9 | -1.9 | 1.9 | -1.4 |
Delay disc. indifference point, 4s delay | 1.9 | 2.0 | 7.1 | -0.9 | 0.9 | 1.6 | -0.9 | 1.0 | 1.4 | 1.7 | 1.9 | 2.0 | -2.0 | 0.6 | -0.4 | 2.7 | 1.8 | 1.9 | 1.8 | -1.8 | -0.2 | 0.2 | 1.9 | 0.8 | 1.6 | 2.1 | 0.4 | 0.5 | -1.0 | 1.2 | 1.2 | 1.6 | 1.2 | -1.6 | 0.8 | 0.5 |
Time >=10cm from walls, locomotor time 1 | 1.9 | 1.9 | 6.2 | -1.2 | 1.2 | 0.8 | -1.4 | 1.3 | 1.2 | 1.2 | 1.6 | 1.8 | -1.7 | 0.7 | -0.6 | 2.5 | 1.7 | 1.6 | 2.1 | -2.1 | 0.2 | -0.2 | 1.7 | 0.4 | 1.6 | 1.9 | 0.9 | -0.0 | -1.3 | 0.8 | 0.7 | 1.1 | 1.7 | -1.6 | 1.3 | -0.2 |
Vertical activity count, locomotor time 2 | 1.9 | 2.1 | 4.8 | 1.7 | -1.7 | -0.3 | 1.7 | -1.7 | -2.0 | -0.5 | -1.0 | -2.1 | 2.1 | -1.4 | 1.3 | -1.9 | -1.4 | -1.0 | -2.2 | 2.0 | -0.8 | 0.8 | -1.4 | 0.3 | -1.2 | -1.4 | -1.5 | 0.5 | 1.5 | -0.2 | 0.0 | -0.4 | -2.0 | 2.0 | -1.8 | 0.9 |
Locomotion in novel chamber post-restriction | 1.9 | 2.2 | 5.6 | 1.5 | -1.5 | 0.2 | 1.6 | -1.6 | -2.3 | 0.2 | -0.6 | -2.1 | 2.1 | -1.4 | 1.3 | -1.7 | -0.6 | -0.6 | -2.2 | 2.4 | -1.3 | 1.3 | -1.3 | 0.4 | -0.5 | -1.0 | -2.0 | 1.5 | 1.3 | 0.5 | 0.8 | 0.2 | -2.3 | 2.0 | -2.2 | 1.5 |
Delay discounting water rate 24 sec | 1.8 | 2.5 | 7.8 | 1.0 | -1.0 | -0.9 | 1.1 | -1.1 | -2.2 | -0.8 | -1.4 | -2.5 | 2.5 | -1.0 | 0.8 | -2.2 | -1.6 | -1.4 | -2.5 | 2.8 | -0.4 | 0.4 | -2.0 | -0.4 | -1.7 | -1.7 | -1.6 | 1.0 | 1.1 | -0.5 | -0.2 | -0.7 | -2.1 | 2.4 | -1.9 | 0.8 |
Locomotor activity | 1.8 | 2.8 | 8.5 | 1.4 | -1.4 | 0.1 | 1.6 | -1.5 | -2.9 | 0.8 | 0.1 | -2.3 | 2.4 | -1.9 | 1.8 | -1.2 | -0.2 | 0.1 | -2.0 | 2.2 | -1.9 | 1.9 | -0.9 | 0.9 | -0.1 | -0.4 | -2.4 | 2.1 | 1.3 | 0.9 | 1.3 | 0.7 | -2.4 | 2.5 | -2.6 | 2.1 |
Std. dev. reaction times | 1.8 | 2.4 | 7.3 | -0.6 | 0.6 | 2.3 | -0.4 | 0.5 | 0.9 | 2.3 | 2.2 | 1.8 | -1.7 | 0.2 | -0.0 | 2.7 | 2.3 | 2.2 | 1.7 | -1.6 | -0.8 | 0.8 | 2.2 | 1.2 | 2.1 | 2.5 | -0.2 | 0.9 | -0.8 | 1.8 | 1.8 | 2.1 | 1.0 | -1.4 | 0.3 | 0.9 |
Time to tail flick, vehicle, before self-admin | 1.8 | 1.8 | 5.5 | -0.6 | 0.7 | 1.1 | -0.6 | 0.6 | 1.4 | 1.6 | 1.9 | 1.7 | -1.9 | 0.2 | -0.1 | 2.1 | 1.8 | 1.9 | 2.0 | -1.8 | -0.7 | 0.7 | 2.4 | 0.9 | 1.8 | 2.1 | 0.4 | -0.4 | -0.7 | 1.3 | 1.1 | 1.5 | 1.1 | -1.2 | 0.6 | 0.5 |
Delay discounting total patch changes 0 sec | 1.7 | 2.7 | 6.1 | -0.3 | 0.2 | -2.5 | -0.3 | 0.2 | -0.5 | -2.4 | -2.4 | -1.2 | 1.3 | 0.7 | -0.9 | -2.2 | -2.4 | -2.4 | -1.5 | 1.7 | 1.5 | -1.5 | -2.4 | -1.9 | -2.4 | -2.3 | 0.7 | -0.6 | -0.0 | -2.3 | -2.3 | -2.4 | -0.5 | 0.4 | 0.4 | -1.5 |
Social time | 1.7 | 2.2 | 5.3 | -2.1 | 2.1 | -0.0 | -2.1 | 2.1 | 1.4 | 0.6 | 0.6 | 1.6 | -1.6 | 1.8 | -1.7 | 2.1 | 0.4 | 0.6 | 1.7 | -1.0 | 1.3 | -1.3 | 2.3 | -0.8 | 0.1 | 1.5 | 1.5 | -1.4 | -2.1 | -0.1 | -0.3 | 0.2 | 1.8 | -1.7 | 1.6 | -0.9 |
Condit. Reinf. active responses | 1.7 | 2.4 | 5.6 | 1.3 | -1.3 | 1.6 | 1.4 | -1.4 | -1.4 | 1.8 | 1.3 | -0.9 | 0.7 | -1.7 | 1.7 | -0.1 | 1.4 | 1.3 | -0.5 | 0.5 | -2.4 | 2.4 | 0.3 | 1.7 | 1.4 | 0.9 | -2.1 | 2.1 | 0.9 | 2.0 | 2.2 | 1.7 | -1.3 | 1.4 | -1.9 | 2.2 |
Short access day 10 total inactive lever presses | 1.7 | 1.9 | 5.5 | 1.4 | -1.4 | -0.7 | 1.3 | -1.3 | -1.5 | -1.2 | -1.2 | -1.8 | 1.8 | -1.2 | 1.1 | -2.3 | -1.6 | -1.2 | -1.9 | 1.6 | -0.1 | 0.1 | -2.3 | 0.1 | -1.3 | -1.9 | -1.0 | 0.6 | 1.6 | -0.7 | -0.5 | -0.8 | -1.6 | 1.8 | -1.2 | 0.3 |
Stereotopy head waving bouts, day 3 | 1.7 | 2.1 | 5.6 | 1.6 | -1.6 | -0.6 | 1.5 | -1.5 | -2.0 | -0.3 | -0.5 | -1.8 | 1.9 | -1.8 | 1.7 | -2.4 | -0.7 | -0.5 | -1.8 | 1.3 | -1.0 | 1.0 | -2.0 | 0.9 | -0.4 | -1.3 | -1.7 | 1.3 | 2.2 | 0.2 | 0.4 | 0.0 | -1.9 | 1.8 | -1.8 | 1.2 |
Time >=10cm from walls, locomotor time 2 | 1.7 | 1.8 | 4.0 | 0.9 | -0.9 | 1.4 | 0.9 | -0.9 | -0.1 | 1.7 | 1.9 | 0.7 | -0.7 | -1.2 | 1.3 | 1.1 | 1.7 | 1.9 | 0.9 | -1.4 | -1.7 | 1.7 | 0.5 | 2.0 | 1.8 | 1.4 | -1.0 | 1.8 | 0.9 | 1.8 | 1.7 | 1.8 | -0.1 | -0.1 | -0.6 | 1.5 |
Condit. Reinf. active minus inactive responses | 1.6 | 2.0 | 4.8 | 1.1 | -1.1 | 1.5 | 1.2 | -1.2 | -1.3 | 1.7 | 1.2 | -0.8 | 0.7 | -1.6 | 1.6 | 0.0 | 1.3 | 1.2 | -0.4 | 0.3 | -2.2 | 2.2 | 0.7 | 1.6 | 1.4 | 0.9 | -1.9 | 1.5 | 0.9 | 1.9 | 2.0 | 1.6 | -1.2 | 1.3 | -1.8 | 2.1 |
Intermittent access day 1 locomotion | 1.6 | 1.7 | 5.9 | -1.9 | 1.9 | -0.2 | -1.9 | 1.9 | 1.6 | 0.4 | 0.3 | 1.4 | -1.5 | 1.8 | -1.8 | 1.9 | 0.8 | 0.3 | 1.4 | -0.8 | 0.9 | -0.9 | 1.4 | -0.9 | 0.3 | 1.2 | 1.2 | -0.4 | -2.4 | -0.1 | -0.2 | 0.1 | 1.4 | -1.4 | 1.4 | -0.9 |
Time in closed arm before self-admin | 1.6 | 1.8 | 6.3 | 1.6 | -1.6 | -0.3 | 1.7 | -1.7 | -1.5 | -0.8 | -1.0 | -1.8 | 1.8 | -1.1 | 1.0 | -2.5 | -1.2 | -1.0 | -1.8 | 1.7 | -0.7 | 0.7 | -1.7 | 0.2 | -1.0 | -1.7 | -1.1 | 0.7 | 1.5 | -0.3 | -0.2 | -0.6 | -1.7 | 1.6 | -1.4 | 0.6 |
Retroperitoneal fat weight | 1.5 | 5.0 | 13.9 | -1.0 | 1.0 | 2.0 | -0.9 | 0.9 | 2.3 | 2.3 | 3.1 | 3.5 | -3.3 | 0.5 | -0.2 | 3.4 | 3.2 | 3.1 | 3.6 | -3.7 | -0.6 | 0.6 | 2.3 | 1.5 | 3.0 | 3.3 | 1.0 | 0.1 | -0.8 | 1.9 | 1.5 | 2.2 | 2.5 | -2.5 | 1.8 | 0.2 |
Delay discounting total patch changes 18 sec | 1.5 | 2.0 | 5.0 | -0.0 | 0.0 | -2.1 | -0.0 | -0.0 | -0.8 | -2.2 | -2.2 | -1.3 | 1.5 | 0.3 | -0.4 | -1.9 | -2.0 | -2.2 | -1.5 | 1.5 | 0.9 | -0.9 | -2.2 | -1.4 | -1.9 | -2.2 | 0.3 | -0.3 | 0.4 | -1.8 | -1.8 | -2.1 | -0.8 | 0.6 | 0.0 | -1.2 |
Social responses | 1.5 | 1.9 | 4.7 | 1.3 | -1.3 | 0.6 | 1.4 | -1.4 | -1.8 | 0.6 | -0.0 | -2.0 | 1.7 | -1.7 | 1.5 | -0.8 | -0.4 | -0.0 | -1.6 | 1.9 | -1.4 | 1.4 | -1.0 | 0.8 | -0.4 | -0.4 | -2.1 | 1.8 | 1.3 | 0.8 | 1.0 | 0.5 | -1.9 | 2.1 | -2.2 | 1.7 |
Intermittent access intake day 1-15 change | 1.5 | 1.5 | 6.6 | 1.1 | -1.0 | -0.9 | 1.0 | -1.0 | -1.4 | -1.0 | -1.2 | -1.8 | 1.7 | -0.9 | 0.8 | -2.6 | -1.5 | -1.2 | -1.9 | 1.6 | -0.1 | 0.1 | -1.7 | -0.1 | -1.2 | -1.7 | -0.8 | 0.4 | 1.0 | -0.7 | -0.5 | -0.9 | -1.5 | 1.6 | -1.1 | 0.3 |
Locomotion velocity, session 7 | 1.5 | 1.7 | 5.1 | -0.1 | 0.1 | 2.3 | -0.0 | 0.1 | 0.9 | 1.7 | 1.8 | 1.3 | -1.5 | -0.0 | 0.1 | 2.1 | 1.7 | 1.8 | 1.6 | -1.4 | -0.9 | 0.9 | 2.1 | 0.9 | 1.8 | 2.0 | -0.1 | 0.2 | -0.7 | 1.6 | 1.4 | 1.6 | 0.9 | -0.9 | 0.2 | 0.7 |
Bone: maximum moment | 1.5 | 2.7 | 5.4 | 2.3 | -2.3 | 0.7 | 2.3 | -2.3 | -2.1 | 0.3 | 0.0 | -1.8 | 1.8 | -2.1 | 2.0 | -2.0 | -0.3 | 0.0 | -1.7 | 1.3 | -1.5 | 1.5 | -1.6 | 1.2 | -0.0 | -0.8 | -2.0 | 1.7 | 2.0 | 0.8 | 0.9 | 0.5 | -2.1 | 2.1 | -2.1 | 1.6 |
Fe content in liver | 1.5 | 1.8 | 7.4 | 1.3 | -1.4 | 0.1 | 1.4 | -1.3 | -1.8 | 0.5 | 0.0 | -1.7 | 1.6 | -1.5 | 1.4 | -1.6 | 0.2 | 0.0 | -1.4 | 1.4 | -1.2 | 1.2 | -1.5 | 0.8 | 0.1 | -0.4 | -1.9 | 2.7 | 1.2 | 0.7 | 1.0 | 0.5 | -1.8 | 1.7 | -1.8 | 1.4 |
Rb content in liver | 1.5 | 1.9 | 4.2 | -2.0 | 2.0 | -0.8 | -1.9 | 1.9 | 1.7 | -0.5 | -0.3 | 1.5 | -1.4 | 1.9 | -1.9 | 1.8 | 0.3 | -0.3 | 1.3 | -0.9 | 1.2 | -1.2 | 0.7 | -1.2 | -0.1 | 0.5 | 1.7 | -1.1 | -1.7 | -0.8 | -0.9 | -0.7 | 1.7 | -1.7 | 1.8 | -1.5 |
Intermittent access intake escalation | 1.4 | 1.4 | 5.5 | 1.0 | -1.0 | -0.8 | 1.0 | -1.0 | -1.4 | -0.8 | -1.0 | -1.8 | 1.7 | -0.9 | 0.8 | -2.4 | -1.2 | -1.0 | -1.8 | 1.6 | -0.3 | 0.3 | -1.5 | -0.0 | -1.1 | -1.5 | -1.0 | 0.7 | 0.9 | -0.5 | -0.3 | -0.7 | -1.6 | 1.7 | -1.3 | 0.5 |
Bone: periosteal estimation | 1.4 | 2.9 | 6.0 | 2.4 | -2.4 | 0.7 | 2.5 | -2.4 | -2.2 | 0.3 | -0.0 | -1.9 | 1.9 | -2.1 | 2.1 | -2.0 | -0.3 | -0.0 | -1.8 | 1.4 | -1.6 | 1.6 | -1.7 | 1.3 | -0.0 | -0.8 | -2.1 | 1.9 | 2.1 | 0.8 | 0.9 | 0.5 | -2.1 | 2.2 | -2.1 | 1.7 |
Co content in liver | 1.4 | 1.6 | 4.2 | 0.1 | -0.1 | -1.5 | 0.1 | -0.1 | -0.9 | -1.8 | -1.9 | -1.4 | 1.5 | 0.2 | -0.3 | -1.8 | -1.9 | -1.9 | -1.6 | 1.6 | 0.7 | -0.7 | -1.7 | -1.1 | -1.8 | -2.0 | 0.1 | -0.7 | 0.4 | -1.5 | -1.4 | -1.7 | -0.9 | 0.8 | -0.3 | -0.8 |
Liver weight, left | 1.3 | 2.0 | 6.4 | 1.1 | -1.2 | -1.3 | 1.1 | -1.1 | -1.4 | -1.7 | -1.7 | -1.7 | 1.9 | -0.8 | 0.7 | -2.5 | -1.8 | -1.7 | -2.0 | 1.5 | 0.2 | -0.2 | -2.5 | -0.4 | -1.6 | -2.3 | -0.6 | 0.2 | 1.5 | -1.2 | -1.1 | -1.5 | -1.5 | 1.4 | -0.8 | -0.3 |
Mean time between licks in bursts | 1.3 | 1.8 | 3.5 | -1.9 | 1.9 | -1.2 | -1.8 | 1.8 | 1.3 | -0.9 | -0.7 | 1.0 | -0.9 | 1.8 | -1.8 | 0.9 | -0.5 | -0.7 | 0.8 | -0.3 | 1.6 | -1.6 | 0.6 | -1.6 | -0.8 | 0.0 | 1.7 | -1.4 | -1.7 | -1.3 | -1.4 | -1.0 | 1.5 | -1.5 | 1.7 | -1.7 |
Condit. Reinf. lever reinforcers received | 1.3 | 1.8 | 4.5 | 0.9 | -0.9 | 1.5 | 1.1 | -1.0 | -1.2 | 1.7 | 1.2 | -0.7 | 0.5 | -1.3 | 1.3 | 0.2 | 1.3 | 1.2 | -0.3 | 0.4 | -2.1 | 2.1 | 0.6 | 1.4 | 1.4 | 1.0 | -1.8 | 1.8 | 0.5 | 1.9 | 2.0 | 1.6 | -1.1 | 1.1 | -1.6 | 2.0 |
Intermitt. access day 1 inactive lever presses | 1.3 | 1.5 | 3.7 | 0.0 | -0.0 | -1.4 | -0.0 | 0.0 | -1.0 | -1.6 | -1.8 | -1.4 | 1.5 | 0.2 | -0.3 | -1.2 | -1.9 | -1.8 | -1.7 | 1.8 | 0.9 | -0.9 | -1.4 | -1.2 | -1.9 | -1.9 | -0.0 | -0.3 | 0.1 | -1.5 | -1.2 | -1.5 | -0.9 | 0.9 | -0.4 | -0.7 |
One hour access (0.3 mA shock) | 1.3 | 1.5 | 3.9 | -0.5 | 0.5 | -1.5 | -0.5 | 0.6 | -0.6 | -1.4 | -1.9 | -1.5 | 1.4 | 0.9 | -1.0 | -0.9 | -1.8 | -1.9 | -1.6 | 2.0 | 0.9 | -0.9 | -0.7 | -1.6 | -1.9 | -1.6 | 0.1 | -0.3 | -1.3 | -1.4 | -1.2 | -1.6 | -0.9 | 0.8 | -0.3 | -0.7 |
Pavlov. Cond. change in total contacts | 1.3 | 1.4 | 3.6 | -0.6 | 0.6 | 1.3 | -0.7 | 0.7 | 0.9 | 1.5 | 1.7 | 1.5 | -1.5 | 0.1 | 0.0 | 1.9 | 1.7 | 1.7 | 1.6 | -1.6 | -0.2 | 0.2 | 1.6 | 0.9 | 1.5 | 1.9 | 0.2 | 0.5 | -0.6 | 1.2 | 1.2 | 1.4 | 1.0 | -1.1 | 0.5 | 0.5 |
Pavlov. Cond. lever contacts | 1.3 | 1.6 | 4.2 | -1.6 | 1.6 | 0.1 | -1.7 | 1.7 | 1.6 | 0.4 | 0.6 | 1.7 | -1.6 | 1.4 | -1.3 | 2.1 | 0.8 | 0.6 | 1.6 | -1.2 | 1.1 | -1.1 | 1.5 | -0.6 | 0.5 | 1.2 | 1.3 | -0.4 | -1.7 | -0.1 | -0.1 | 0.2 | 1.7 | -1.6 | 1.5 | -0.9 |
Bone: maximum diameter | 1.3 | 2.3 | 5.5 | 2.3 | -2.3 | 0.9 | 2.3 | -2.3 | -1.8 | 0.4 | 0.2 | -1.4 | 1.5 | -2.0 | 2.0 | -1.7 | -0.0 | 0.2 | -1.3 | 0.8 | -1.4 | 1.4 | -1.5 | 1.3 | 0.2 | -0.6 | -1.8 | 2.0 | 2.0 | 0.9 | 1.0 | 0.6 | -1.7 | 1.8 | -1.8 | 1.5 |
Time in closed arm after self-admin | 1.3 | 1.3 | 4.9 | 0.6 | -0.6 | -0.8 | 0.9 | -0.9 | -1.4 | -0.6 | -1.3 | -2.0 | 1.8 | -0.5 | 0.3 | -2.0 | -1.2 | -1.3 | -1.9 | 2.2 | -0.4 | 0.4 | -1.0 | -0.5 | -1.2 | -1.3 | -1.0 | 0.5 | 0.4 | -0.5 | -0.2 | -0.6 | -1.6 | 1.5 | -1.3 | 0.5 |
Intraocular pressure | 1.2 | 1.7 | 4.9 | 1.6 | -1.6 | -0.3 | 1.5 | -1.5 | -1.6 | -0.2 | -0.5 | -1.7 | 1.6 | -1.4 | 1.3 | -2.2 | -0.8 | -0.5 | -1.7 | 1.7 | -0.6 | 0.6 | -1.9 | 0.5 | -0.7 | -1.0 | -1.6 | 1.7 | 1.4 | 0.1 | 0.3 | -0.1 | -1.9 | 1.8 | -1.6 | 1.0 |
Soleus weight | 1.2 | 3.5 | 7.6 | 2.5 | -2.5 | 0.2 | 2.5 | -2.5 | -2.5 | -0.1 | -0.5 | -2.3 | 2.4 | -2.0 | 1.9 | -2.8 | -0.6 | -0.5 | -2.3 | 1.9 | -1.2 | 1.2 | -2.5 | 0.9 | -0.4 | -1.3 | -2.2 | 2.5 | 2.1 | 0.4 | 0.6 | 0.1 | -2.4 | 2.4 | -2.2 | 1.5 |
Pavlov. Cond. magazine entry number | 1.2 | 1.5 | 5.4 | 1.2 | -1.2 | -1.2 | 1.1 | -1.2 | -1.4 | -1.1 | -1.1 | -1.4 | 1.6 | -1.1 | 1.1 | -2.3 | -1.5 | -1.1 | -1.7 | 1.1 | -0.0 | 0.0 | -2.1 | 0.1 | -1.2 | -1.8 | -0.7 | 0.4 | 1.8 | -0.8 | -0.6 | -0.8 | -1.4 | 1.3 | -0.9 | 0.1 |
Short access day 1 locomotion | 1.2 | 1.3 | 4.1 | -1.3 | 1.3 | 0.6 | -1.4 | 1.4 | 1.3 | 1.0 | 0.9 | 1.4 | -1.5 | 1.1 | -1.1 | 1.9 | 1.2 | 0.9 | 1.5 | -1.2 | 0.4 | -0.4 | 2.0 | -0.1 | 1.0 | 1.5 | 0.8 | -0.6 | -1.7 | 0.5 | 0.5 | 0.7 | 1.3 | -1.2 | 1.0 | -0.2 |
Short access total locomotion | 1.2 | 1.3 | 3.3 | -1.0 | 1.0 | 0.5 | -1.1 | 1.1 | 1.7 | 0.6 | 0.9 | 1.7 | -1.8 | 1.1 | -1.0 | 1.8 | 1.1 | 0.9 | 1.7 | -1.4 | 0.5 | -0.5 | 1.4 | -0.1 | 0.9 | 1.3 | 1.0 | -0.7 | -1.5 | 0.3 | 0.1 | 0.5 | 1.5 | -1.3 | 1.2 | -0.5 |
Run reversals in cocaine runway, males | 1.2 | 1.2 | 2.7 | -0.5 | 0.5 | -1.3 | -0.5 | 0.5 | -0.5 | -1.3 | -1.7 | -0.9 | 1.1 | 0.8 | -0.9 | -1.2 | -1.5 | -1.7 | -1.2 | 1.6 | 1.1 | -1.1 | -0.7 | -1.5 | -1.6 | -1.4 | 0.3 | -0.8 | -0.6 | -1.4 | -1.2 | -1.4 | -0.4 | 0.5 | 0.0 | -0.8 |
Indifference point 0 sec | 1.1 | 1.8 | 4.5 | 0.0 | -0.0 | -2.1 | 0.0 | -0.0 | -0.4 | -2.0 | -1.9 | -0.9 | 1.1 | 0.5 | -0.6 | -2.0 | -1.9 | -1.9 | -1.2 | 1.3 | 1.2 | -1.2 | -2.1 | -1.4 | -1.9 | -2.0 | 0.5 | -0.4 | 0.2 | -1.9 | -1.9 | -2.0 | -0.5 | 0.3 | 0.3 | -1.2 |
Delay discounting total patch changes 6 sec | 1.1 | 1.6 | 5.2 | 0.1 | -0.1 | -2.2 | 0.1 | -0.1 | -0.6 | -1.8 | -1.8 | -1.3 | 1.3 | 0.0 | -0.2 | -1.7 | -1.8 | -1.8 | -1.5 | 1.5 | 0.7 | -0.7 | -2.3 | -1.0 | -1.8 | -2.0 | 0.0 | 0.0 | 0.6 | -1.6 | -1.5 | -1.8 | -0.9 | 0.8 | -0.2 | -0.7 |
Delay discounting water rate 12 sec | 1.1 | 1.6 | 5.6 | -0.2 | 0.2 | -1.4 | -0.2 | 0.2 | -1.5 | -1.2 | -1.8 | -1.9 | 1.9 | 0.2 | -0.4 | -1.4 | -1.8 | -1.8 | -2.0 | 2.4 | 0.5 | -0.5 | -1.4 | -1.3 | -2.0 | -1.6 | -0.5 | 0.2 | -0.2 | -1.1 | -0.9 | -1.3 | -1.1 | 1.1 | -0.7 | -0.2 |
Reaction time number correct | 1.1 | 1.5 | 3.9 | 0.5 | -0.5 | -1.3 | 0.6 | -0.6 | -1.1 | -1.4 | -1.8 | -1.9 | 1.7 | -0.3 | 0.1 | -1.8 | -1.7 | -1.8 | -1.8 | 2.0 | -0.0 | 0.0 | -1.7 | -0.9 | -1.6 | -1.9 | -0.6 | 0.0 | 0.4 | -1.0 | -0.9 | -1.4 | -1.3 | 1.3 | -0.9 | -0.3 |
Reaction time trials correct on left | 1.1 | 1.5 | 3.9 | 0.5 | -0.5 | -1.3 | 0.6 | -0.6 | -1.1 | -1.4 | -1.8 | -1.9 | 1.7 | -0.3 | 0.1 | -1.8 | -1.7 | -1.8 | -1.8 | 2.0 | -0.0 | 0.0 | -1.7 | -0.9 | -1.6 | -1.9 | -0.6 | 0.0 | 0.4 | -1.0 | -0.9 | -1.4 | -1.3 | 1.3 | -0.9 | -0.3 |
Condit. Reinf. active-inactive response ratio | 1.1 | 1.1 | 3.0 | 0.4 | -0.3 | 1.4 | 0.5 | -0.5 | -0.7 | 1.6 | 1.2 | -0.2 | 0.1 | -0.9 | 0.9 | 0.7 | 1.3 | 1.2 | 0.1 | -0.1 | -1.6 | 1.6 | 1.3 | 1.2 | 1.4 | 1.1 | -1.1 | 0.8 | 0.2 | 1.6 | 1.7 | 1.4 | -0.6 | 0.6 | -1.1 | 1.5 |
Progressive ratio test 1 inactive lever presses | 1.1 | 1.2 | 3.7 | 0.6 | -0.6 | -0.7 | 0.6 | -0.6 | -1.4 | -0.9 | -1.3 | -1.8 | 1.8 | -0.3 | 0.2 | -1.2 | -1.4 | -1.3 | -1.8 | 1.9 | -0.1 | 0.1 | -1.1 | -0.6 | -1.3 | -1.5 | -0.8 | 0.5 | 0.2 | -0.7 | -0.4 | -0.9 | -1.5 | 1.5 | -1.1 | 0.2 |
Short access day 1 total infusions | 1.1 | 1.2 | 2.8 | -1.0 | 1.0 | -0.2 | -1.1 | 1.1 | 1.6 | -0.4 | 0.2 | 1.7 | -1.5 | 1.2 | -1.1 | 0.9 | 0.3 | 0.2 | 1.5 | -1.5 | 1.0 | -1.0 | 0.5 | -0.5 | 0.3 | 0.5 | 1.5 | -1.5 | -0.9 | -0.5 | -0.8 | -0.4 | 1.7 | -1.5 | 1.7 | -1.3 |
Locomotion distance, session 2 | 1.1 | 1.5 | 4.2 | -2.0 | 2.1 | -1.1 | -2.0 | 2.0 | 0.8 | -0.7 | -0.9 | 0.3 | -0.3 | 1.7 | -1.7 | 1.0 | -0.5 | -0.9 | 0.2 | 0.6 | 1.4 | -1.4 | 0.9 | -1.7 | -0.9 | -0.1 | 1.2 | -1.5 | -1.9 | -1.1 | -1.0 | -1.0 | 0.8 | -0.8 | 1.0 | -1.3 |
Locomotion velocity, hab. session 1 | 1.1 | 1.5 | 4.8 | -1.7 | 1.7 | 0.6 | -1.7 | 1.7 | 1.4 | 0.7 | 0.7 | 1.5 | -1.5 | 1.4 | -1.3 | 2.2 | 1.2 | 0.7 | 1.5 | -1.0 | 0.5 | -0.5 | 1.6 | -0.5 | 0.8 | 1.4 | 1.0 | -0.6 | -1.8 | 0.2 | 0.1 | 0.4 | 1.4 | -1.5 | 1.2 | -0.5 |
Bone: cortical thickness | 1.1 | 1.3 | 2.7 | 1.5 | -1.5 | 0.7 | 1.6 | -1.5 | -1.6 | 0.5 | 0.2 | -1.3 | 1.3 | -1.3 | 1.2 | -1.3 | -0.0 | 0.2 | -1.2 | 1.1 | -1.2 | 1.2 | -0.6 | 0.8 | 0.1 | -0.2 | -1.6 | 1.4 | 1.1 | 0.8 | 0.9 | 0.6 | -1.5 | 1.4 | -1.6 | 1.3 |
Sum of active levers in priming session hrs 5-6 | 1.1 | 1.1 | 3.3 | -0.4 | 0.4 | 1.0 | -0.4 | 0.4 | 1.0 | 1.0 | 1.5 | 1.7 | -1.5 | 0.2 | 0.0 | 1.4 | 1.5 | 1.5 | 1.6 | -1.8 | -0.2 | 0.2 | 0.9 | 0.8 | 1.4 | 1.4 | 0.4 | 0.1 | -0.2 | 0.9 | 0.7 | 1.1 | 1.1 | -1.4 | 0.8 | 0.1 |
Number of licking bursts | 1.0 | 1.2 | 3.4 | 1.1 | -1.1 | -0.5 | 0.9 | -1.0 | -1.3 | -1.1 | -1.2 | -1.6 | 1.6 | -0.7 | 0.5 | -1.8 | -1.6 | -1.2 | -1.8 | 1.4 | 0.2 | -0.2 | -0.8 | -0.3 | -1.3 | -1.6 | -0.5 | -0.9 | 1.1 | -0.7 | -0.7 | -0.9 | -1.3 | 1.4 | -0.9 | 0.0 |
Delay discounting water rate 6 sec | 1.0 | 1.5 | 4.6 | 0.1 | -0.1 | -1.2 | 0.2 | -0.2 | -1.5 | -1.1 | -1.6 | -1.8 | 1.9 | -0.0 | -0.1 | -1.9 | -1.5 | -1.6 | -1.9 | 2.1 | 0.3 | -0.3 | -1.8 | -1.1 | -1.8 | -1.5 | -0.6 | 0.8 | -0.0 | -0.9 | -0.8 | -1.2 | -1.2 | 1.3 | -0.8 | -0.2 |
Reaction time trials on left | 1.0 | 1.4 | 3.7 | 0.5 | -0.5 | -1.2 | 0.5 | -0.6 | -1.0 | -1.3 | -1.7 | -1.8 | 1.7 | -0.3 | 0.1 | -1.7 | -1.6 | -1.7 | -1.8 | 1.9 | -0.0 | 0.0 | -1.7 | -0.9 | -1.5 | -1.8 | -0.6 | 0.0 | 0.4 | -0.9 | -0.8 | -1.4 | -1.2 | 1.3 | -0.9 | -0.2 |
Reaction time trials completed | 1.0 | 1.4 | 3.7 | 0.5 | -0.5 | -1.2 | 0.5 | -0.6 | -1.0 | -1.3 | -1.7 | -1.8 | 1.7 | -0.3 | 0.1 | -1.7 | -1.6 | -1.7 | -1.8 | 1.9 | -0.0 | 0.0 | -1.7 | -0.9 | -1.5 | -1.8 | -0.6 | 0.0 | 0.4 | -0.9 | -0.8 | -1.4 | -1.2 | 1.3 | -0.9 | -0.2 |
Short access total infusions | 1.0 | 1.1 | 3.4 | -0.4 | 0.4 | 1.0 | -0.5 | 0.5 | 1.4 | 0.6 | 1.2 | 1.8 | -1.7 | 0.5 | -0.4 | 1.4 | 1.2 | 1.2 | 1.8 | -1.9 | 0.1 | -0.1 | 1.2 | 0.5 | 1.2 | 1.3 | 0.8 | -0.9 | -0.7 | 0.5 | 0.3 | 0.7 | 1.4 | -1.2 | 1.1 | -0.3 |
One hour access (shock baseline) | 1.0 | 1.2 | 3.3 | 0.9 | -0.8 | -0.1 | 0.9 | -0.8 | -1.7 | 0.0 | -0.6 | -1.8 | 1.7 | -0.8 | 0.6 | -1.3 | -0.5 | -0.6 | -1.7 | 1.7 | -0.9 | 0.9 | -0.9 | 0.2 | -0.5 | -0.8 | -1.5 | 1.5 | 0.2 | 0.2 | 0.5 | 0.0 | -1.7 | 1.7 | -1.6 | 1.0 |
Bone: marrow area | 1.0 | 2.1 | 5.4 | 1.3 | -1.3 | -1.0 | 1.3 | -1.3 | -1.7 | -1.2 | -1.5 | -2.1 | 2.1 | -1.0 | 0.9 | -2.3 | -1.7 | -1.5 | -2.2 | 2.0 | -0.2 | 0.2 | -2.2 | -0.3 | -1.5 | -2.0 | -1.0 | 0.5 | 1.3 | -0.8 | -0.7 | -1.1 | -1.7 | 1.9 | -1.3 | 0.3 |
Fecal boli incidents, locomotor time 1 | 1.0 | 1.1 | 3.1 | 1.2 | -1.2 | -0.1 | 1.2 | -1.2 | -1.3 | 0.3 | -0.1 | -1.5 | 1.2 | -1.3 | 1.3 | -0.7 | -0.2 | -0.1 | -1.2 | 1.4 | -1.2 | 1.2 | -0.9 | 0.5 | -0.1 | -0.4 | -1.5 | 0.9 | 1.0 | 0.6 | 0.7 | 0.4 | -1.5 | 1.8 | -1.6 | 1.2 |
Bouts of movement, locomotor time 1 | 1.0 | 1.1 | 2.4 | 1.3 | -1.3 | 0.0 | 1.4 | -1.3 | -1.0 | 0.1 | -0.3 | -1.5 | 1.1 | -1.4 | 1.3 | -1.5 | -0.5 | -0.3 | -1.3 | 1.2 | -0.9 | 0.9 | -0.9 | 0.6 | -0.3 | -0.7 | -1.4 | 1.1 | 1.1 | 0.4 | 0.5 | 0.1 | -1.4 | 1.4 | -1.5 | 1.0 |
Bouts of movement, locomotor time 2 | 1.0 | 1.1 | 3.3 | 1.2 | -1.2 | 0.2 | 1.2 | -1.2 | -1.1 | 0.0 | -0.3 | -1.3 | 1.1 | -1.2 | 1.1 | -1.8 | -0.4 | -0.3 | -1.3 | 1.2 | -0.6 | 0.6 | -1.3 | 0.6 | -0.3 | -0.7 | -1.4 | 1.6 | 1.1 | 0.3 | 0.5 | 0.1 | -1.4 | 1.1 | -1.4 | 1.0 |
Sr content in liver | 1.0 | 0.9 | 3.7 | 0.4 | -0.4 | -0.8 | 0.3 | -0.3 | -0.6 | -1.4 | -1.3 | -0.8 | 1.0 | 0.0 | -0.1 | -1.9 | -1.5 | -1.3 | -1.1 | 0.9 | 0.7 | -0.7 | -1.3 | -0.6 | -1.3 | -1.6 | 0.2 | -1.0 | 0.6 | -1.2 | -1.1 | -1.2 | -0.5 | 0.4 | -0.1 | -0.6 |
Locomotor testing distance | 0.9 | 1.5 | 4.5 | 0.7 | -0.7 | -1.0 | 0.7 | -0.8 | -2.1 | -0.6 | -1.0 | -2.0 | 2.1 | -0.9 | 0.8 | -1.7 | -1.2 | -1.0 | -1.8 | 2.0 | -0.5 | 0.5 | -1.7 | -0.2 | -1.1 | -1.3 | -1.1 | 0.8 | 0.9 | -0.5 | -0.2 | -0.6 | -1.7 | 1.7 | -1.4 | 0.5 |
Reaction time omissions | 0.9 | 1.2 | 6.4 | -1.3 | 1.3 | 0.7 | -1.3 | 1.3 | 0.9 | 1.2 | 1.1 | 1.4 | -1.3 | 0.9 | -0.8 | 2.5 | 1.1 | 1.1 | 1.3 | -1.0 | 0.1 | -0.1 | 1.7 | 0.1 | 0.9 | 1.7 | 0.5 | 0.0 | -1.2 | 0.8 | 0.6 | 0.9 | 1.2 | -1.2 | 0.8 | 0.0 |
Reaction time trials AUC | 0.9 | 1.3 | 3.5 | 0.3 | -0.3 | -1.4 | 0.3 | -0.4 | -0.8 | -1.4 | -1.8 | -1.7 | 1.5 | -0.1 | -0.1 | -1.5 | -1.6 | -1.8 | -1.7 | 1.9 | 0.1 | -0.1 | -1.6 | -1.1 | -1.5 | -1.8 | -0.4 | -0.1 | 0.2 | -1.1 | -0.9 | -1.5 | -1.1 | 1.1 | -0.7 | -0.4 |
Pavlov. Cond. latency score | 0.9 | 1.1 | 4.0 | -0.8 | 0.9 | 1.2 | -0.7 | 0.8 | 0.9 | 1.3 | 1.2 | 1.1 | -1.2 | 0.6 | -0.6 | 2.0 | 1.6 | 1.2 | 1.3 | -0.9 | -0.4 | 0.4 | 1.7 | 0.3 | 1.3 | 1.7 | 0.2 | 0.2 | -1.3 | 1.0 | 1.0 | 1.0 | 1.0 | -0.8 | 0.4 | 0.3 |
Pavlov. Cond. lever-magazine prob. diff. | 0.9 | 1.1 | 4.1 | -1.0 | 1.0 | 1.1 | -0.9 | 0.9 | 0.8 | 1.3 | 1.1 | 1.0 | -1.2 | 0.7 | -0.7 | 2.0 | 1.5 | 1.1 | 1.3 | -0.7 | -0.4 | 0.4 | 1.8 | 0.1 | 1.3 | 1.7 | 0.2 | 0.2 | -1.5 | 1.0 | 1.0 | 1.0 | 0.9 | -0.8 | 0.4 | 0.4 |
Pavlov. Cond. response bias | 0.9 | 1.2 | 4.0 | -1.0 | 1.0 | 1.1 | -0.8 | 0.9 | 0.8 | 1.5 | 1.3 | 1.0 | -1.2 | 0.6 | -0.5 | 2.0 | 1.8 | 1.3 | 1.3 | -0.8 | -0.7 | 0.7 | 1.6 | 0.3 | 1.5 | 1.8 | 0.0 | 0.6 | -1.4 | 1.2 | 1.1 | 1.2 | 0.8 | -0.8 | 0.3 | 0.5 |
Intermittent access total locomotion | 0.9 | 1.0 | 5.7 | -1.7 | 1.7 | -0.5 | -1.7 | 1.8 | 0.9 | 0.3 | -0.1 | 0.6 | -0.7 | 1.6 | -1.6 | 1.3 | 0.4 | -0.1 | 0.6 | -0.0 | 0.8 | -0.8 | 1.2 | -1.0 | -0.1 | 0.7 | 0.7 | -0.1 | -2.4 | -0.2 | -0.1 | -0.1 | 0.8 | -0.8 | 0.8 | -0.6 |
Locomotion distance, session 1 | 0.9 | 1.2 | 3.0 | -1.7 | 1.7 | -0.3 | -1.7 | 1.7 | 1.1 | -0.2 | -0.1 | 0.9 | -0.9 | 1.5 | -1.5 | 1.5 | 0.2 | -0.1 | 0.9 | -0.4 | 1.0 | -1.0 | 1.1 | -1.1 | -0.1 | 0.5 | 1.2 | -1.1 | -1.7 | -0.5 | -0.5 | -0.4 | 1.2 | -1.2 | 1.2 | -1.0 |
Locomotion distance, session 8 | 0.9 | 1.4 | 3.7 | 1.2 | -1.2 | 1.1 | 1.3 | -1.3 | -1.2 | 1.0 | 0.8 | -0.8 | 0.8 | -1.5 | 1.6 | -0.5 | 0.8 | 0.8 | -0.5 | 0.5 | -1.6 | 1.6 | -0.3 | 1.2 | 0.9 | 0.4 | -1.6 | 1.9 | 1.0 | 1.2 | 1.4 | 1.1 | -1.2 | 1.2 | -1.5 | 1.6 |
Total zone transitions, hab. session 1 | 0.9 | 1.3 | 3.9 | -1.7 | 1.7 | 0.1 | -1.7 | 1.7 | 1.2 | 0.4 | 0.3 | 1.1 | -1.2 | 1.5 | -1.5 | 1.9 | 0.7 | 0.3 | 1.1 | -0.5 | 0.7 | -0.7 | 1.6 | -0.9 | 0.3 | 1.0 | 1.1 | -1.0 | -2.0 | -0.1 | -0.1 | 0.0 | 1.2 | -1.3 | 1.1 | -0.7 |
Pavlov. Cond. intertrial magazine entries | 0.9 | 1.1 | 2.2 | -1.1 | 1.1 | -0.9 | -1.1 | 1.1 | 0.9 | -0.9 | -0.8 | 0.5 | -0.5 | 1.4 | -1.5 | 0.7 | -0.7 | -0.8 | 0.3 | 0.0 | 1.3 | -1.3 | 0.3 | -1.4 | -0.8 | -0.3 | 1.3 | -1.4 | -1.3 | -1.1 | -1.2 | -1.1 | 1.0 | -0.9 | 1.2 | -1.4 |
Bone: endosteal estimation | 0.9 | 2.0 | 5.2 | 1.4 | -1.4 | -0.8 | 1.4 | -1.4 | -1.7 | -1.1 | -1.4 | -2.0 | 2.0 | -1.1 | 1.0 | -2.3 | -1.6 | -1.4 | -2.1 | 1.9 | -0.3 | 0.3 | -2.1 | -0.2 | -1.4 | -1.9 | -1.0 | 0.6 | 1.4 | -0.7 | -0.6 | -0.9 | -1.7 | 1.9 | -1.3 | 0.3 |
Breakpoint value in progressive ratio session | 0.9 | 1.1 | 2.5 | 0.2 | -0.2 | 1.2 | 0.4 | -0.3 | -0.3 | 1.6 | 1.4 | 0.4 | -0.4 | -0.6 | 0.7 | 0.9 | 1.6 | 1.4 | 0.5 | -0.6 | -1.1 | 1.1 | 0.7 | 1.2 | 1.5 | 1.3 | -0.9 | 1.5 | 0.1 | 1.5 | 1.6 | 1.5 | -0.4 | -0.1 | -0.6 | 1.4 |
Extinction: sum of active levers before priming | 0.9 | 0.9 | 3.0 | -1.2 | 1.2 | 0.3 | -1.2 | 1.2 | 1.0 | 0.6 | 0.7 | 1.3 | -1.2 | 0.9 | -0.9 | 1.7 | 0.9 | 0.7 | 1.2 | -1.1 | 0.3 | -0.3 | 1.1 | -0.1 | 0.7 | 1.1 | 0.7 | -0.3 | -1.1 | 0.3 | 0.2 | 0.4 | 1.1 | -1.4 | 1.0 | -0.4 |
Total resting periods, locomotor time 2 | 0.9 | 1.0 | 3.8 | 1.2 | -1.2 | 0.1 | 1.2 | -1.2 | -0.9 | -0.1 | -0.3 | -1.3 | 1.1 | -1.2 | 1.1 | -1.9 | -0.4 | -0.3 | -1.2 | 1.0 | -0.5 | 0.5 | -1.3 | 0.6 | -0.3 | -0.8 | -1.3 | 1.5 | 1.2 | 0.2 | 0.4 | 0.0 | -1.3 | 1.1 | -1.3 | 0.9 |
Weight adjusted by age | 0.9 | 1.0 | 3.5 | 1.5 | -1.5 | -0.2 | 1.5 | -1.5 | -1.2 | -0.8 | -0.7 | -1.0 | 1.3 | -0.8 | 0.7 | -1.9 | -1.0 | -0.7 | -1.2 | 0.8 | -0.1 | 0.1 | -1.6 | 0.1 | -0.7 | -1.2 | -0.7 | 0.5 | 1.3 | -0.4 | -0.3 | -0.5 | -1.0 | 0.8 | -0.8 | 0.2 |
Times rat made contact with spout | 0.8 | 0.9 | 1.8 | 1.2 | -1.2 | 0.9 | 1.2 | -1.2 | -1.3 | 0.6 | 0.4 | -1.0 | 1.0 | -1.2 | 1.2 | -0.9 | 0.3 | 0.4 | -0.7 | 0.5 | -1.1 | 1.1 | -0.1 | 0.9 | 0.5 | -0.0 | -1.3 | 0.6 | 1.0 | 0.9 | 1.0 | 0.6 | -1.2 | 1.2 | -1.3 | 1.2 |
Light reinforcement 1 | 0.8 | 1.5 | 4.4 | -1.1 | 1.1 | 1.3 | -1.0 | 1.0 | 0.8 | 1.5 | 1.6 | 1.4 | -1.4 | 0.6 | -0.5 | 1.8 | 1.8 | 1.6 | 1.7 | -1.3 | -0.4 | 0.4 | 2.1 | 0.4 | 1.7 | 2.0 | 0.4 | -0.2 | -1.2 | 1.1 | 1.0 | 1.4 | 1.3 | -1.0 | 0.6 | 0.2 |
Cocaine response after cond. not corrected | 0.8 | 0.9 | 3.1 | 0.5 | -0.6 | 1.1 | 0.5 | -0.5 | 0.6 | 0.9 | 1.4 | 1.3 | -1.1 | -0.5 | 0.7 | 0.7 | 1.3 | 1.4 | 1.3 | -1.8 | -0.5 | 0.5 | 0.4 | 1.3 | 1.3 | 1.0 | -0.1 | 1.0 | 0.7 | 1.0 | 0.9 | 1.1 | 0.7 | -0.7 | 0.3 | 0.5 |
Pavlov. Cond. index score | 0.8 | 1.0 | 3.7 | -0.9 | 0.9 | 1.1 | -0.8 | 0.8 | 0.8 | 1.3 | 1.1 | 0.9 | -1.1 | 0.6 | -0.6 | 1.9 | 1.5 | 1.1 | 1.2 | -0.7 | -0.5 | 0.5 | 1.7 | 0.2 | 1.3 | 1.7 | 0.1 | 0.3 | -1.4 | 1.0 | 1.0 | 1.0 | 0.9 | -0.7 | 0.3 | 0.4 |
Degree of sensitization distance | 0.8 | 0.9 | 3.6 | -0.9 | 0.9 | 1.0 | -0.8 | 0.8 | 0.9 | 1.0 | 0.9 | 1.0 | -1.2 | 0.6 | -0.6 | 1.8 | 1.0 | 0.9 | 1.2 | -0.9 | -0.1 | 0.1 | 1.9 | 0.1 | 0.9 | 1.3 | 0.5 | -0.7 | -1.1 | 0.7 | 0.6 | 0.8 | 0.9 | -1.0 | 0.6 | 0.1 |
Bone: periosteal perimeter | 0.8 | 1.3 | 3.7 | 1.4 | -1.4 | 1.0 | 1.6 | -1.5 | -1.3 | 0.9 | 0.6 | -1.0 | 0.9 | -1.3 | 1.3 | -0.6 | 0.6 | 0.6 | -0.8 | 0.7 | -1.4 | 1.4 | -0.7 | 1.0 | 0.6 | 0.2 | -1.6 | 1.9 | 0.9 | 1.1 | 1.2 | 0.9 | -1.3 | 1.4 | -1.4 | 1.5 |
Bone: tissue strength | 0.8 | 0.8 | 2.2 | -0.2 | 0.2 | -1.3 | -0.3 | 0.3 | 0.1 | -1.5 | -1.3 | -0.3 | 0.4 | 0.4 | -0.4 | -1.0 | -1.3 | -1.3 | -0.6 | 0.5 | 1.0 | -1.0 | -1.1 | -0.9 | -1.3 | -1.3 | 0.7 | -0.8 | 0.1 | -1.3 | -1.3 | -1.4 | -0.0 | 0.0 | 0.5 | -1.1 |
Delay disc. indifference point, 16s delay | 0.8 | 0.8 | 2.7 | -0.7 | 0.7 | 0.9 | -0.7 | 0.7 | 0.6 | 1.2 | 1.2 | 1.1 | -1.1 | 0.3 | -0.3 | 1.6 | 1.0 | 1.2 | 1.0 | -0.8 | -0.2 | 0.2 | 1.5 | 0.4 | 1.0 | 1.5 | 0.2 | -0.0 | -0.7 | 0.8 | 0.8 | 1.0 | 0.7 | -0.8 | 0.3 | 0.3 |
Delay disc. indifference point, 24s delay | 0.8 | 0.7 | 2.9 | -0.9 | 0.9 | 0.8 | -1.0 | 0.9 | 0.9 | 0.7 | 0.8 | 1.1 | -1.1 | 0.7 | -0.6 | 1.7 | 0.7 | 0.8 | 1.1 | -0.8 | 0.3 | -0.3 | 1.5 | -0.0 | 0.6 | 1.2 | 0.6 | -0.7 | -1.0 | 0.3 | 0.3 | 0.5 | 0.9 | -1.0 | 0.6 | -0.1 |
Total resting periods, locomotor time 1 | 0.8 | 0.9 | 2.0 | 1.2 | -1.2 | 0.1 | 1.2 | -1.2 | -0.9 | 0.2 | -0.1 | -1.3 | 0.9 | -1.3 | 1.3 | -1.2 | -0.3 | -0.1 | -1.1 | 1.0 | -0.9 | 0.9 | -0.8 | 0.7 | -0.1 | -0.4 | -1.3 | 1.1 | 1.0 | 0.5 | 0.6 | 0.3 | -1.3 | 1.3 | -1.4 | 1.1 |
Heart weight | 0.7 | 1.0 | 5.3 | -1.1 | 1.1 | -1.1 | -0.9 | 0.9 | -0.9 | -0.6 | -1.3 | -1.5 | 1.3 | 0.7 | -0.9 | 0.4 | -1.0 | -1.3 | -1.5 | 2.3 | 0.1 | -0.1 | 0.1 | -1.4 | -1.3 | -0.8 | -0.3 | -0.7 | -1.1 | -0.7 | -0.4 | -1.0 | -1.0 | 0.9 | -0.7 | -0.1 |
Indifference point AUC | 0.7 | 0.8 | 2.0 | 0.6 | -0.6 | -0.5 | 0.6 | -0.7 | -1.2 | -0.3 | -0.6 | -1.4 | 1.3 | -1.0 | 0.9 | -1.3 | -0.6 | -0.6 | -1.3 | 1.2 | -0.7 | 0.7 | -1.1 | 0.3 | -0.4 | -0.9 | -1.1 | 0.9 | 1.0 | 0.0 | 0.2 | -0.3 | -1.4 | 1.4 | -1.2 | 0.6 |
Conditioned reinforcement - inactives | 0.7 | 0.8 | 1.9 | 0.4 | -0.3 | -0.9 | 0.3 | -0.3 | -1.0 | -1.0 | -1.2 | -1.1 | 1.3 | -0.1 | 0.0 | -1.4 | -1.3 | -1.2 | -1.4 | 1.3 | 0.4 | -0.4 | -1.1 | -0.6 | -1.2 | -1.4 | -0.3 | 0.0 | 0.0 | -0.9 | -0.7 | -0.9 | -1.0 | 0.9 | -0.5 | -0.2 |
Intermittent access day 1 total infusions | 0.7 | 0.8 | 3.6 | -1.3 | 1.4 | 0.0 | -1.4 | 1.4 | 0.9 | 0.3 | 0.2 | 0.8 | -0.8 | 1.3 | -1.3 | 1.4 | 0.5 | 0.2 | 0.8 | -0.4 | 0.5 | -0.5 | 1.3 | -0.6 | 0.2 | 0.9 | 0.7 | -0.3 | -1.9 | -0.0 | -0.0 | 0.1 | 0.9 | -0.8 | 0.8 | -0.5 |
Progressive ratio test 2 active lever presses | 0.7 | 0.7 | 2.0 | 0.7 | -0.6 | 0.0 | 0.7 | -0.7 | -1.3 | 0.2 | -0.4 | -1.4 | 1.3 | -0.6 | 0.5 | -1.0 | -0.3 | -0.4 | -1.3 | 1.4 | -0.8 | 0.8 | -0.3 | 0.2 | -0.3 | -0.5 | -1.2 | 1.0 | -0.0 | 0.3 | 0.5 | 0.1 | -1.4 | 1.4 | -1.3 | 0.9 |
Short access day 10 total infusions | 0.7 | 0.7 | 2.1 | -1.0 | 1.0 | -0.1 | -1.0 | 1.0 | 1.2 | -0.1 | 0.2 | 1.2 | -1.2 | 1.1 | -1.0 | 1.2 | 0.4 | 0.2 | 1.1 | -0.9 | 0.7 | -0.7 | 0.7 | -0.5 | 0.2 | 0.6 | 1.0 | -0.6 | -1.5 | -0.2 | -0.4 | -0.1 | 1.2 | -0.9 | 1.2 | -0.8 |
Condit. Reinf. active minus inactive responses | 0.7 | 0.7 | 2.3 | -0.7 | 0.7 | 0.5 | -0.7 | 0.7 | 1.1 | 0.7 | 0.8 | 1.3 | -1.3 | 0.7 | -0.6 | 1.5 | 0.9 | 0.8 | 1.3 | -1.2 | 0.1 | -0.1 | 1.1 | 0.1 | 0.8 | 1.2 | 0.7 | -0.2 | -0.9 | 0.4 | 0.3 | 0.5 | 1.2 | -1.1 | 0.9 | -0.3 |
Condit. Reinf. active-inactive response ratio | 0.7 | 0.7 | 1.9 | -0.2 | 0.2 | 1.0 | -0.2 | 0.2 | 0.8 | 1.1 | 1.3 | 1.1 | -1.2 | 0.1 | -0.0 | 1.3 | 1.3 | 1.3 | 1.2 | -1.3 | -0.4 | 0.4 | 1.1 | 0.7 | 1.1 | 1.4 | 0.2 | 0.3 | -0.4 | 0.9 | 0.8 | 1.0 | 0.8 | -0.8 | 0.5 | 0.3 |
Time in familiar zone, hab. session 1 | 0.7 | 0.6 | 1.9 | -0.4 | 0.4 | -0.9 | -0.6 | 0.5 | 0.7 | -1.1 | -0.7 | 0.4 | -0.3 | 0.6 | -0.6 | -0.2 | -0.8 | -0.7 | 0.2 | -0.4 | 1.4 | -1.4 | -0.5 | -0.7 | -0.8 | -0.7 | 1.0 | -0.8 | -0.1 | -1.1 | -1.2 | -1.0 | 0.6 | -0.7 | 1.0 | -1.1 |
Time in novel zone, hab. session 1 | 0.7 | 0.7 | 1.8 | 0.7 | -0.7 | 1.0 | 0.8 | -0.8 | -0.7 | 0.9 | 0.8 | -0.3 | 0.3 | -0.9 | 0.9 | 0.1 | 0.8 | 0.8 | -0.1 | 0.1 | -1.3 | 1.3 | 0.2 | 0.9 | 0.8 | 0.6 | -1.0 | 0.9 | 0.5 | 1.1 | 1.1 | 0.9 | -0.6 | 0.7 | -1.0 | 1.1 |
Bone: endosteal perimeter | 0.7 | 1.4 | 3.4 | 1.4 | -1.4 | -0.1 | 1.5 | -1.4 | -1.6 | -0.2 | -0.6 | -1.7 | 1.6 | -1.2 | 1.1 | -1.5 | -0.6 | -0.6 | -1.6 | 1.6 | -0.8 | 0.8 | -1.6 | 0.3 | -0.6 | -1.0 | -1.4 | 1.5 | 1.1 | 0.2 | 0.3 | -0.1 | -1.6 | 1.8 | -1.5 | 0.9 |
Distance traveled before self-admin | 0.7 | 0.7 | 4.0 | -1.1 | 1.1 | 0.1 | -1.1 | 1.1 | 1.0 | 0.8 | 0.7 | 0.8 | -1.1 | 0.6 | -0.5 | 2.0 | 1.0 | 0.7 | 1.1 | -0.7 | -0.1 | 0.1 | 1.4 | -0.1 | 0.8 | 1.1 | 0.4 | -0.5 | -0.9 | 0.4 | 0.5 | 0.6 | 0.8 | -0.8 | 0.5 | 0.0 |
Time to tail flick, test, before self-admin | 0.7 | 0.7 | 2.1 | 1.2 | -1.2 | 0.8 | 1.3 | -1.3 | -1.0 | 0.1 | -0.1 | -0.9 | 0.9 | -1.1 | 1.1 | -1.4 | -0.1 | -0.1 | -0.8 | 0.6 | -0.9 | 0.9 | -0.7 | 0.7 | 0.1 | -0.4 | -1.0 | 0.5 | 1.0 | 0.4 | 0.5 | 0.2 | -0.9 | 1.0 | -1.0 | 0.9 |
Progressive ratio | 0.7 | 0.8 | 1.5 | -0.9 | 0.9 | -1.0 | -1.0 | 1.0 | 0.9 | -0.7 | -0.6 | 0.6 | -0.5 | 1.1 | -1.0 | 0.2 | -0.5 | -0.6 | 0.3 | -0.3 | 1.2 | -1.2 | 0.4 | -1.1 | -0.6 | -0.2 | 1.2 | -1.1 | -1.0 | -1.0 | -1.0 | -0.8 | 1.0 | -0.9 | 1.1 | -1.2 |
Glucose | 0.6 | 1.0 | 2.7 | -0.4 | 0.5 | 1.1 | -0.4 | 0.4 | 1.0 | 1.0 | 1.2 | 1.3 | -1.4 | 0.4 | -0.3 | 1.6 | 1.3 | 1.2 | 1.5 | -1.5 | -0.4 | 0.4 | 1.6 | 0.5 | 1.2 | 1.4 | 0.5 | -0.5 | -0.6 | 0.8 | 0.7 | 0.9 | 1.1 | -1.2 | 0.7 | 0.1 |
Reaction time mean minus median AUC | 0.6 | 0.7 | 2.9 | -1.0 | 1.0 | 1.0 | -0.8 | 0.8 | 0.4 | 1.2 | 0.9 | 0.7 | -0.7 | 0.5 | -0.5 | 1.7 | 1.1 | 0.9 | 0.7 | -0.3 | -0.3 | 0.3 | 1.3 | 0.2 | 0.8 | 1.4 | -0.1 | 0.6 | -1.0 | 0.9 | 0.9 | 1.1 | 0.5 | -0.7 | 0.1 | 0.4 |
Reaction time false alarm rate | 0.6 | 0.9 | 2.6 | -0.7 | 0.7 | 0.9 | -0.7 | 0.7 | 0.4 | 1.4 | 1.3 | 0.8 | -0.9 | 0.3 | -0.2 | 1.6 | 1.5 | 1.3 | 1.0 | -0.6 | -0.3 | 0.3 | 1.4 | 0.5 | 1.3 | 1.6 | -0.2 | 0.8 | -0.9 | 1.0 | 1.1 | 1.2 | 0.5 | -0.6 | 0.1 | 0.7 |
Pavlov. Cond. lever latency | 0.6 | 0.8 | 2.5 | 0.4 | -0.4 | -1.1 | 0.2 | -0.3 | -0.2 | -1.4 | -1.1 | -0.4 | 0.6 | 0.0 | -0.0 | -1.4 | -1.6 | -1.1 | -0.7 | 0.4 | 1.1 | -1.1 | -1.3 | -0.6 | -1.4 | -1.4 | 0.5 | -0.8 | 0.7 | -1.3 | -1.3 | -1.2 | -0.2 | 0.2 | 0.3 | -0.9 |
Pavlov. Cond. lever contacts | 0.6 | 0.8 | 2.5 | -0.4 | 0.4 | 1.1 | -0.3 | 0.3 | 0.4 | 1.3 | 1.1 | 0.7 | -0.8 | 0.1 | -0.1 | 1.4 | 1.6 | 1.1 | 0.9 | -0.6 | -0.9 | 0.9 | 1.1 | 0.6 | 1.4 | 1.5 | -0.3 | 0.9 | -0.7 | 1.2 | 1.1 | 1.1 | 0.4 | -0.4 | -0.0 | 0.7 |
Intermittent access intake escalation 2 | 0.6 | 0.6 | 2.1 | 0.1 | -0.0 | -1.1 | -0.0 | 0.0 | -0.5 | -0.9 | -1.0 | -0.9 | 0.9 | 0.1 | -0.2 | -1.5 | -1.1 | -1.0 | -1.0 | 1.0 | 0.6 | -0.6 | -0.8 | -0.6 | -1.1 | -1.1 | -0.0 | -0.0 | -0.1 | -0.8 | -0.7 | -0.9 | -0.6 | 0.6 | -0.2 | -0.3 |
Lifetime Intake | 0.6 | 0.6 | 1.7 | -0.7 | 0.8 | 0.5 | -0.8 | 0.8 | 1.1 | 0.4 | 0.7 | 1.2 | -1.2 | 0.8 | -0.7 | 1.1 | 0.8 | 0.7 | 1.2 | -1.0 | 0.2 | -0.2 | 1.0 | -0.0 | 0.7 | 0.9 | 0.6 | -0.4 | -1.3 | 0.3 | 0.2 | 0.4 | 1.0 | -0.8 | 0.8 | -0.3 |
Short access day 10 total locomotion | 0.6 | 0.7 | 1.4 | -1.0 | 1.0 | -0.9 | -1.1 | 1.0 | 0.9 | -0.7 | -0.6 | 0.5 | -0.5 | 1.2 | -1.2 | 0.4 | -0.4 | -0.6 | 0.4 | -0.1 | 1.1 | -1.1 | -0.1 | -1.0 | -0.6 | -0.2 | 1.0 | -0.8 | -1.2 | -0.9 | -0.9 | -0.8 | 0.8 | -0.6 | 1.0 | -1.1 |
Bone: cortical apparent density | 0.6 | 0.8 | 2.4 | -0.4 | 0.4 | 1.1 | -0.4 | 0.4 | 1.0 | 1.0 | 1.1 | 1.2 | -1.3 | 0.3 | -0.3 | 1.5 | 1.2 | 1.1 | 1.4 | -1.2 | -0.2 | 0.2 | 1.6 | 0.4 | 1.1 | 1.4 | 0.4 | 0.0 | -0.7 | 0.7 | 0.7 | 0.9 | 1.0 | -1.1 | 0.6 | 0.1 |
Bone: cortical tissue density | 0.6 | 0.8 | 2.2 | -0.5 | 0.5 | 1.0 | -0.5 | 0.5 | 1.0 | 0.8 | 1.0 | 1.2 | -1.3 | 0.5 | -0.4 | 1.5 | 1.1 | 1.0 | 1.3 | -1.2 | -0.0 | 0.0 | 1.5 | 0.3 | 1.0 | 1.3 | 0.5 | -0.1 | -0.7 | 0.6 | 0.5 | 0.7 | 1.0 | -1.1 | 0.7 | -0.0 |
Bone: stiffness | 0.6 | 1.0 | 2.0 | 1.1 | -1.1 | 0.8 | 1.2 | -1.1 | -1.2 | 0.9 | 0.5 | -1.0 | 0.9 | -1.2 | 1.2 | -0.5 | 0.3 | 0.5 | -0.8 | 0.8 | -1.1 | 1.1 | -0.2 | 0.9 | 0.3 | 0.2 | -1.4 | 1.3 | 0.8 | 1.0 | 1.0 | 0.9 | -1.2 | 1.2 | -1.4 | 1.4 |
Time to tail flick, test, after self-admin | 0.6 | 0.6 | 1.4 | 0.4 | -0.4 | 1.0 | 0.4 | -0.4 | 0.3 | 1.0 | 1.2 | 0.6 | -0.7 | -0.6 | 0.7 | 0.2 | 1.1 | 1.2 | 0.8 | -1.0 | -0.8 | 0.8 | 0.5 | 1.0 | 1.2 | 0.9 | -0.3 | 0.4 | 0.5 | 1.0 | 0.8 | 1.0 | 0.3 | -0.1 | -0.1 | 0.7 |
Ambulatory time before self-admin | 0.6 | 0.6 | 2.5 | -0.9 | 0.9 | 0.3 | -0.7 | 0.8 | 0.6 | 1.2 | 1.0 | 0.6 | -0.9 | 0.3 | -0.2 | 1.6 | 1.2 | 1.0 | 0.9 | -0.5 | -0.4 | 0.4 | 1.2 | 0.1 | 1.0 | 1.2 | -0.0 | 0.4 | -0.7 | 0.8 | 0.8 | 1.0 | 0.6 | -0.5 | 0.2 | 0.4 |
Delay disc. indifference point, 8s delay | 0.6 | 0.6 | 2.3 | -0.9 | 0.9 | 0.5 | -0.7 | 0.7 | 0.3 | 1.0 | 1.0 | 1.0 | -0.8 | 0.5 | -0.4 | 1.5 | 1.0 | 1.0 | 0.7 | -0.5 | -0.1 | 0.1 | 1.3 | 0.1 | 0.8 | 1.2 | 0.2 | 0.1 | -0.9 | 0.6 | 0.7 | 0.9 | 0.6 | -0.9 | 0.3 | 0.3 |
Locomotion in novel chamber | 0.6 | 0.8 | 3.1 | -0.0 | 0.1 | -1.0 | -0.1 | 0.1 | -0.9 | -0.8 | -1.2 | -1.6 | 1.3 | 0.0 | -0.2 | -1.1 | -1.1 | -1.2 | -1.4 | 1.8 | 0.2 | -0.2 | -0.7 | -0.9 | -1.2 | -1.1 | -0.4 | -0.3 | -0.2 | -0.7 | -0.5 | -0.8 | -0.9 | 1.2 | -0.8 | -0.1 |
Food consumed during 24 hour testing period | 0.5 | 0.6 | 1.8 | 0.6 | -0.6 | -0.5 | 0.6 | -0.6 | -0.7 | -1.1 | -1.2 | -0.9 | 1.1 | -0.0 | -0.1 | -1.2 | -1.1 | -1.2 | -1.0 | 0.8 | 0.4 | -0.4 | -0.9 | -0.5 | -0.9 | -1.3 | -0.1 | -0.5 | 0.5 | -0.7 | -0.7 | -1.1 | -0.6 | 0.6 | -0.3 | -0.4 |
Locomotor testing rearing | 0.5 | 0.7 | 2.7 | -0.6 | 0.5 | -1.7 | -0.5 | 0.4 | -0.4 | -1.2 | -1.2 | -0.4 | 0.7 | 0.5 | -0.5 | -0.8 | -1.1 | -1.2 | -0.6 | 0.8 | 0.8 | -0.8 | -1.2 | -1.0 | -1.2 | -1.1 | 0.5 | -0.2 | -0.2 | -1.2 | -1.2 | -1.2 | -0.1 | -0.1 | 0.4 | -0.9 |
Cocaine response after cond. corrected | 0.5 | 0.5 | 2.9 | 0.6 | -0.6 | 0.9 | 0.5 | -0.6 | 0.6 | 0.4 | 1.0 | 1.2 | -0.9 | -0.5 | 0.6 | 0.4 | 0.8 | 1.0 | 1.1 | -1.7 | -0.3 | 0.3 | 0.2 | 1.0 | 1.0 | 0.6 | 0.2 | 0.3 | 0.8 | 0.5 | 0.4 | 0.6 | 0.7 | -0.7 | 0.5 | 0.1 |
Pavlov. Cond. intertrial magazine entries | 0.5 | 0.7 | 1.8 | 0.6 | -0.6 | -0.6 | 0.6 | -0.6 | -1.3 | -0.4 | -0.6 | -1.3 | 1.4 | -0.7 | 0.6 | -1.3 | -0.8 | -0.6 | -1.3 | 1.3 | -0.4 | 0.4 | -1.0 | -0.0 | -0.7 | -0.9 | -0.8 | 0.4 | 0.8 | -0.2 | -0.0 | -0.3 | -1.2 | 1.2 | -1.0 | 0.4 |
Intermittent access standard deviation | 0.5 | 0.5 | 2.0 | 0.7 | -0.7 | -0.5 | 0.6 | -0.6 | -0.2 | -1.1 | -0.8 | -0.5 | 0.6 | -0.3 | 0.3 | -1.4 | -1.1 | -0.8 | -0.7 | 0.4 | 0.5 | -0.5 | -1.4 | -0.2 | -0.8 | -1.3 | 0.0 | -0.3 | 0.6 | -0.8 | -0.8 | -0.8 | -0.4 | 0.4 | -0.1 | -0.4 |
Stereotopy head waving bouts, day 7 | 0.5 | 0.6 | 1.9 | -1.4 | 1.4 | -0.6 | -1.4 | 1.4 | 0.7 | -0.2 | -0.2 | 0.5 | -0.5 | 1.1 | -1.1 | 0.8 | 0.0 | -0.2 | 0.5 | -0.1 | 0.7 | -0.7 | 0.6 | -0.8 | -0.2 | 0.2 | 0.8 | -0.8 | -1.2 | -0.5 | -0.4 | -0.4 | 0.7 | -0.8 | 0.8 | -0.7 |
Stereotopy head waving duration, day 7 | 0.5 | 0.6 | 1.5 | -1.2 | 1.2 | -0.4 | -1.2 | 1.2 | 0.8 | -0.1 | -0.0 | 0.8 | -0.7 | 1.0 | -1.0 | 0.9 | 0.1 | -0.0 | 0.7 | -0.5 | 0.6 | -0.6 | 0.8 | -0.6 | -0.0 | 0.4 | 0.9 | -1.0 | -1.1 | -0.4 | -0.4 | -0.2 | 0.9 | -0.9 | 0.9 | -0.7 |
Condit. Reinf. inactive responses | 0.5 | 0.6 | 2.1 | -1.4 | 1.4 | -0.8 | -1.3 | 1.3 | 0.5 | -0.3 | -0.5 | 0.2 | -0.3 | 1.2 | -1.2 | 0.8 | -0.2 | -0.5 | 0.2 | 0.5 | 0.7 | -0.7 | 0.5 | -1.2 | -0.5 | 0.0 | 0.7 | -0.6 | -1.4 | -0.6 | -0.5 | -0.6 | 0.5 | -0.6 | 0.6 | -0.7 |
Total locomotion distance, hab. session 1 | 0.5 | 0.8 | 2.6 | -1.1 | 1.1 | 0.7 | -1.1 | 1.1 | 0.9 | 0.7 | 0.7 | 1.1 | -1.1 | 0.8 | -0.8 | 1.6 | 1.1 | 0.7 | 1.2 | -0.9 | 0.1 | -0.1 | 1.1 | -0.1 | 0.8 | 1.1 | 0.6 | -0.1 | -1.2 | 0.4 | 0.3 | 0.5 | 1.0 | -1.1 | 0.8 | -0.2 |
Delta time to tail flick, vehicle, before/after SA | 0.5 | 0.5 | 1.1 | -0.6 | 0.6 | -0.9 | -0.6 | 0.6 | 0.1 | -0.9 | -0.9 | -0.2 | 0.2 | 0.7 | -0.8 | -0.3 | -0.8 | -0.9 | -0.3 | 0.5 | 0.7 | -0.7 | -0.5 | -1.0 | -0.9 | -0.6 | 0.6 | -0.5 | -0.6 | -0.9 | -0.9 | -1.0 | 0.3 | -0.2 | 0.5 | -0.9 |
Rest time, locomotor task time 1 | 0.5 | 0.5 | 1.2 | 1.0 | -1.0 | 0.2 | 0.9 | -0.9 | -0.8 | 0.4 | 0.3 | -0.7 | 0.6 | -1.1 | 1.0 | -0.7 | 0.1 | 0.3 | -0.5 | 0.2 | -0.8 | 0.8 | -0.5 | 0.8 | 0.3 | -0.0 | -0.9 | 1.1 | 0.9 | 0.7 | 0.6 | 0.5 | -0.7 | 0.9 | -0.9 | 0.9 |
Cu content in liver | 0.5 | 0.6 | 1.6 | -0.5 | 0.5 | -1.1 | -0.5 | 0.5 | -0.0 | -1.1 | -1.2 | -0.5 | 0.5 | 0.5 | -0.6 | -0.2 | -0.9 | -1.2 | -0.5 | 0.8 | 0.8 | -0.8 | -0.9 | -1.1 | -1.0 | -0.9 | 0.5 | -0.3 | -0.4 | -1.1 | -1.0 | -1.3 | -0.0 | 0.2 | 0.4 | -0.9 |
Mn content in liver | 0.5 | 0.5 | 1.7 | -0.8 | 0.8 | -0.6 | -0.8 | 0.8 | 0.8 | -0.8 | -0.5 | 0.6 | -0.5 | 0.8 | -0.7 | 0.5 | -0.2 | -0.5 | 0.5 | -0.4 | 0.7 | -0.7 | 0.4 | -0.7 | -0.2 | -0.3 | 1.1 | -1.3 | -0.7 | -0.8 | -0.7 | -0.8 | 0.8 | -0.6 | 0.9 | -1.1 |
Na content in liver | 0.5 | 0.5 | 0.9 | 0.6 | -0.6 | 0.9 | 0.6 | -0.6 | -0.2 | 0.9 | 0.9 | 0.2 | -0.2 | -0.7 | 0.8 | 0.3 | 0.9 | 0.9 | 0.3 | -0.4 | -0.9 | 0.9 | 0.3 | 0.9 | 1.0 | 0.7 | -0.6 | 0.9 | 0.5 | 1.0 | 0.9 | 0.9 | -0.2 | 0.3 | -0.5 | 0.8 |
Delay discounting total patch changes 12 sec | 0.4 | 0.5 | 2.6 | 0.5 | -0.5 | -1.1 | 0.5 | -0.5 | -0.3 | -1.0 | -0.8 | -0.6 | 0.6 | -0.3 | 0.3 | -1.2 | -0.9 | -0.8 | -0.8 | 0.5 | 0.3 | -0.3 | -1.6 | -0.2 | -0.7 | -1.1 | -0.1 | 0.4 | 0.8 | -0.8 | -0.8 | -0.9 | -0.6 | 0.5 | -0.1 | -0.3 |
Condit. Reinf. inactive responses | 0.4 | 0.4 | 1.6 | 0.7 | -0.7 | 0.1 | 0.8 | -0.8 | -0.8 | 0.3 | 0.0 | -0.8 | 0.7 | -0.7 | 0.7 | -0.7 | 0.0 | 0.0 | -0.6 | 0.7 | -0.8 | 0.8 | -0.8 | 0.4 | -0.0 | -0.2 | -0.9 | 1.3 | 0.5 | 0.4 | 0.4 | 0.3 | -0.8 | 0.9 | -0.9 | 0.7 |
Intermittent access total infusions | 0.4 | 0.5 | 2.4 | -0.9 | 0.9 | 0.2 | -1.0 | 1.0 | 0.8 | 0.3 | 0.3 | 0.8 | -0.8 | 0.9 | -0.9 | 1.0 | 0.6 | 0.3 | 0.8 | -0.5 | 0.3 | -0.3 | 0.9 | -0.3 | 0.4 | 0.7 | 0.5 | -0.1 | -1.5 | 0.1 | 0.1 | 0.2 | 0.7 | -0.6 | 0.6 | -0.3 |
Intermittent access day 15 total locomotion | 0.4 | 0.4 | 2.1 | -0.7 | 0.7 | -0.9 | -0.8 | 0.8 | -0.3 | -0.2 | -0.8 | -0.8 | 0.6 | 0.8 | -0.9 | -0.0 | -0.4 | -0.8 | -0.8 | 1.2 | 0.4 | -0.4 | 0.0 | -1.0 | -0.7 | -0.3 | -0.1 | 0.6 | -1.4 | -0.5 | -0.2 | -0.4 | -0.5 | 0.5 | -0.2 | -0.1 |
Locomotion velocity, session 1 | 0.4 | 0.5 | 1.6 | -0.9 | 0.9 | 0.3 | -0.8 | 0.9 | 0.7 | 0.6 | 0.6 | 0.8 | -0.9 | 0.6 | -0.6 | 1.3 | 0.7 | 0.6 | 0.9 | -0.5 | -0.1 | 0.1 | 1.1 | -0.1 | 0.6 | 0.9 | 0.4 | -0.4 | -0.9 | 0.3 | 0.3 | 0.4 | 0.8 | -0.7 | 0.5 | -0.1 |
Locomotion distance, session 3 | 0.4 | 0.5 | 1.1 | -0.1 | 0.1 | -0.7 | -0.1 | 0.1 | -0.1 | -0.9 | -1.0 | -0.5 | 0.5 | 0.3 | -0.4 | -0.7 | -1.0 | -1.0 | -0.6 | 0.8 | 0.9 | -0.9 | -0.8 | -0.9 | -1.1 | -0.8 | 0.3 | 0.1 | -0.4 | -0.9 | -0.9 | -1.0 | -0.1 | 0.3 | 0.2 | -0.7 |
Locomotion velocity, session 8 | 0.4 | 0.5 | 1.3 | 0.2 | -0.2 | 0.6 | 0.3 | -0.2 | -0.2 | 1.1 | 1.0 | 0.2 | -0.3 | -0.7 | 0.8 | 0.5 | 1.1 | 1.0 | 0.4 | -0.4 | -1.0 | 1.0 | 0.8 | 1.0 | 1.1 | 0.9 | -0.6 | 0.6 | 0.3 | 1.1 | 1.1 | 1.1 | -0.2 | 0.2 | -0.5 | 0.9 |
Degree of sensitization stereotypy | 0.4 | 0.4 | 1.0 | -1.0 | 1.0 | -0.0 | -1.0 | 1.0 | 0.7 | 0.2 | 0.2 | 0.8 | -0.8 | 0.8 | -0.8 | 1.0 | 0.5 | 0.2 | 0.8 | -0.5 | 0.4 | -0.4 | 0.8 | -0.4 | 0.3 | 0.6 | 0.6 | -0.4 | -1.0 | -0.0 | -0.0 | 0.1 | 0.8 | -0.7 | 0.7 | -0.4 |
Incentive salience index mean | 0.4 | 0.5 | 1.4 | -0.9 | 0.9 | 0.0 | -0.8 | 0.9 | 0.9 | 0.3 | 0.3 | 0.9 | -0.9 | 0.9 | -0.8 | 1.2 | 0.5 | 0.3 | 0.9 | -0.5 | 0.4 | -0.4 | 0.7 | -0.4 | 0.2 | 0.7 | 0.7 | -0.0 | -1.1 | -0.0 | -0.1 | 0.1 | 0.9 | -0.9 | 0.8 | -0.5 |
Total locomotion distance, NPP test | 0.4 | 0.6 | 1.8 | -0.5 | 0.5 | 1.0 | -0.5 | 0.5 | 0.3 | 1.2 | 1.1 | 0.6 | -0.7 | 0.1 | -0.0 | 1.3 | 1.3 | 1.1 | 0.8 | -0.5 | -0.5 | 0.5 | 0.9 | 0.5 | 1.1 | 1.3 | -0.3 | 0.7 | -0.6 | 1.0 | 1.0 | 1.0 | 0.3 | -0.3 | -0.1 | 0.6 |
Pavlov. Cond. latency score | 0.4 | 0.6 | 1.8 | -0.7 | 0.7 | 0.5 | -0.7 | 0.7 | 0.7 | 0.9 | 0.9 | 1.0 | -1.0 | 0.3 | -0.2 | 1.3 | 0.9 | 0.9 | 1.0 | -0.8 | 0.3 | -0.3 | 1.1 | 0.2 | 0.8 | 1.2 | 0.3 | 0.7 | -0.8 | 0.6 | 0.6 | 0.7 | 0.8 | -0.7 | 0.5 | 0.1 |
Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 2.5 | -0.5 | 0.5 | -0.2 | -0.5 | 0.4 | 0.8 | -0.7 | -0.4 | 0.6 | -0.5 | 0.8 | -0.8 | 0.4 | -0.4 | -0.4 | 0.5 | -0.6 | 0.6 | -0.6 | 0.2 | -0.6 | -0.3 | -0.3 | 1.0 | -1.6 | -0.4 | -0.7 | -0.9 | -0.7 | 0.8 | -0.8 | 1.0 | -1.0 |
Bone: elastic displacement | 0.4 | 0.5 | 1.3 | 0.9 | -0.9 | -0.1 | 0.9 | -0.9 | -1.1 | -0.2 | -0.3 | -0.9 | 1.0 | -0.7 | 0.6 | -1.1 | -0.4 | -0.3 | -0.9 | 0.7 | -0.5 | 0.5 | -0.9 | 0.3 | -0.2 | -0.7 | -0.8 | 0.5 | 0.8 | 0.0 | 0.1 | -0.1 | -0.9 | 0.8 | -0.8 | 0.4 |
Delta distance traveled before/after self-admin | 0.4 | 0.4 | 1.5 | 0.6 | -0.6 | 0.1 | 0.6 | -0.7 | -0.8 | -0.6 | -0.7 | -0.9 | 1.0 | -0.3 | 0.2 | -1.2 | -0.9 | -0.7 | -1.0 | 0.9 | 0.1 | -0.1 | -0.8 | -0.2 | -0.8 | -0.8 | -0.3 | -0.1 | 0.3 | -0.5 | -0.4 | -0.6 | -0.7 | 0.8 | -0.5 | -0.1 |
Delta time to tail flick, test, before/after SA | 0.4 | 0.3 | 0.8 | -0.7 | 0.7 | -0.3 | -0.7 | 0.7 | 0.9 | 0.1 | 0.4 | 0.9 | -0.9 | 0.4 | -0.4 | 0.8 | 0.4 | 0.4 | 0.8 | -0.9 | 0.5 | -0.5 | 0.3 | -0.1 | 0.3 | 0.5 | 0.6 | -0.0 | -0.3 | -0.1 | -0.2 | 0.2 | 0.8 | -0.8 | 0.8 | -0.4 |
Change in fecal boli incidents, locomotor task | 0.4 | 0.4 | 1.5 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 | 0.5 | -0.2 | 0.1 | 1.0 | -0.6 | 0.6 | -0.6 | 0.7 | 0.1 | 0.1 | 0.8 | -1.2 | 0.5 | -0.5 | 0.5 | -0.0 | 0.2 | 0.2 | 0.9 | -0.7 | -0.3 | -0.3 | -0.4 | -0.2 | 0.9 | -1.1 | 1.0 | -0.8 |
Seeking ratio, punishment vs. effort | 0.4 | 0.4 | 1.4 | 0.8 | -0.8 | -0.1 | 0.8 | -0.8 | -0.8 | -0.4 | -0.4 | -0.8 | 0.9 | -0.8 | 0.7 | -0.8 | -0.5 | -0.4 | -0.8 | 0.7 | -0.3 | 0.3 | -1.2 | 0.2 | -0.4 | -0.8 | -0.7 | 0.6 | 1.0 | -0.1 | -0.1 | -0.3 | -0.9 | 0.9 | -0.7 | 0.3 |
Run reversals in cocaine runway, females | 0.4 | 0.4 | 0.7 | -0.8 | 0.8 | -0.8 | -0.8 | 0.8 | 0.6 | -0.5 | -0.4 | 0.4 | -0.4 | 0.7 | -0.7 | 0.2 | -0.0 | -0.4 | 0.4 | -0.3 | 0.5 | -0.5 | 0.1 | -0.7 | -0.1 | -0.2 | 0.8 | -0.6 | -0.6 | -0.5 | -0.6 | -0.6 | 0.7 | -0.7 | 0.8 | -0.8 |
Latency to leave start box in cocaine runway | 0.4 | 0.5 | 1.3 | 0.0 | -0.0 | 1.1 | 0.1 | -0.1 | 0.3 | 0.9 | 1.0 | 0.9 | -0.7 | -0.1 | 0.1 | 0.8 | 1.1 | 1.0 | 0.9 | -1.0 | -0.5 | 0.5 | 1.1 | 0.7 | 1.1 | 1.0 | 0.0 | -0.2 | -0.1 | 0.8 | 0.7 | 0.9 | 0.4 | -0.4 | 0.1 | 0.4 |
Latency to leave start box in cocaine runway, M | 0.4 | 0.4 | 2.0 | -1.2 | 1.2 | -0.3 | -1.0 | 1.1 | 0.4 | 0.1 | -0.1 | 0.2 | -0.3 | 1.1 | -1.1 | 0.8 | 0.3 | -0.1 | 0.3 | 0.4 | 0.4 | -0.4 | 0.7 | -0.9 | -0.0 | 0.4 | 0.4 | -0.5 | -1.4 | -0.2 | -0.1 | -0.1 | 0.5 | -0.4 | 0.4 | -0.4 |
Mean num. licks in bursts | 0.3 | 0.3 | 1.2 | -0.2 | 0.2 | 0.6 | -0.1 | 0.1 | 0.2 | 0.8 | 0.8 | 0.6 | -0.5 | -0.1 | 0.2 | 0.6 | 1.1 | 0.8 | 0.8 | -0.6 | -0.6 | 0.6 | 0.2 | 0.5 | 0.9 | 0.8 | -0.2 | 0.8 | -0.2 | 0.7 | 0.8 | 0.8 | 0.3 | -0.4 | 0.0 | 0.4 |
Indifference point function ln k | 0.3 | 0.5 | 1.3 | -0.0 | 0.0 | -0.6 | 0.0 | -0.0 | -0.4 | -0.8 | -1.1 | -0.7 | 0.7 | 0.4 | -0.5 | -0.6 | -1.0 | -1.1 | -0.8 | 1.1 | 0.7 | -0.7 | -0.6 | -0.9 | -1.2 | -0.9 | 0.1 | -0.4 | -0.4 | -0.9 | -0.8 | -0.9 | -0.3 | 0.2 | -0.0 | -0.6 |
Indifference point function log k | 0.3 | 0.5 | 1.3 | -0.0 | 0.0 | -0.6 | 0.0 | -0.0 | -0.4 | -0.8 | -1.1 | -0.7 | 0.7 | 0.4 | -0.5 | -0.6 | -1.0 | -1.1 | -0.8 | 1.1 | 0.7 | -0.7 | -0.6 | -0.9 | -1.2 | -0.9 | 0.1 | -0.4 | -0.4 | -0.9 | -0.8 | -0.9 | -0.3 | 0.2 | -0.0 | -0.6 |
Delay discounting water rate 18 sec | 0.3 | 0.4 | 1.9 | -0.7 | 0.7 | -0.3 | -0.6 | 0.7 | -0.7 | -0.1 | -0.7 | -0.7 | 0.8 | 0.6 | -0.7 | -0.2 | -0.7 | -0.7 | -0.7 | 1.4 | 0.5 | -0.5 | 0.1 | -0.9 | -1.0 | -0.2 | -0.2 | 0.0 | -0.9 | -0.4 | -0.2 | -0.4 | -0.3 | 0.3 | -0.3 | 0.0 |
Reaction time num false alarms | 0.3 | 0.5 | 1.8 | -0.6 | 0.6 | 0.7 | -0.5 | 0.6 | 0.3 | 1.0 | 0.7 | 0.2 | -0.5 | 0.4 | -0.4 | 1.3 | 1.1 | 0.7 | 0.5 | 0.0 | -0.3 | 0.3 | 1.2 | 0.0 | 0.9 | 1.0 | -0.2 | 0.5 | -1.1 | 0.7 | 0.9 | 0.7 | 0.2 | -0.3 | -0.1 | 0.5 |
Condit. Reinf. lever presses | 0.3 | 0.4 | 1.8 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.6 | 0.6 | 0.4 | -0.5 | 0.4 | -0.6 | 0.6 | -0.1 | 0.6 | 0.4 | -0.2 | 0.3 | -1.0 | 1.0 | -0.2 | 0.5 | 0.5 | 0.3 | -0.8 | 1.3 | 0.2 | 0.8 | 0.7 | 0.5 | -0.4 | 0.7 | -0.7 | 0.7 |
Intermitt. access escalation Index | 0.3 | 0.2 | 0.7 | -0.8 | 0.8 | -0.5 | -0.6 | 0.7 | 0.0 | -0.3 | -0.6 | -0.2 | 0.2 | 0.7 | -0.8 | 0.1 | -0.3 | -0.6 | -0.2 | 0.5 | 0.2 | -0.2 | 0.1 | -0.8 | -0.5 | -0.1 | 0.3 | -0.0 | -0.8 | -0.4 | -0.5 | -0.5 | 0.1 | -0.2 | 0.3 | -0.5 |
Intermittent access day 15 total infusions | 0.3 | 0.3 | 0.9 | -0.3 | 0.3 | -0.7 | -0.4 | 0.4 | -0.3 | -0.6 | -0.8 | -0.6 | 0.6 | 0.5 | -0.5 | -0.6 | -0.7 | -0.8 | -0.7 | 0.9 | 0.4 | -0.4 | -0.4 | -0.7 | -0.8 | -0.7 | -0.1 | 0.2 | -0.9 | -0.6 | -0.4 | -0.7 | -0.5 | 0.6 | -0.2 | -0.2 |
Cocaine induced anxiety | 0.3 | 0.3 | 0.9 | -0.8 | 0.8 | -0.3 | -0.8 | 0.8 | 0.7 | 0.4 | 0.4 | 0.6 | -0.7 | 0.5 | -0.5 | 0.9 | 0.6 | 0.4 | 0.7 | -0.4 | 0.3 | -0.3 | 0.5 | -0.2 | 0.3 | 0.7 | 0.3 | 0.3 | -0.9 | 0.2 | 0.1 | 0.3 | 0.7 | -0.5 | 0.5 | -0.2 |
Progressive ratio test 1 breakpoint | 0.3 | 0.3 | 0.8 | 0.8 | -0.8 | 0.6 | 0.8 | -0.7 | -0.8 | 0.2 | 0.1 | -0.6 | 0.6 | -0.6 | 0.6 | -0.4 | -0.1 | 0.1 | -0.5 | 0.5 | -0.7 | 0.7 | -0.0 | 0.4 | 0.1 | -0.1 | -0.7 | 0.4 | 0.2 | 0.4 | 0.5 | 0.3 | -0.7 | 0.9 | -0.8 | 0.7 |
Progressive ratio test 2 breakpoint | 0.3 | 0.4 | 1.4 | 0.3 | -0.2 | 0.0 | 0.3 | -0.2 | -1.0 | 0.2 | -0.3 | -1.1 | 1.0 | -0.2 | 0.2 | -0.6 | -0.2 | -0.3 | -1.0 | 1.2 | -0.6 | 0.6 | 0.2 | -0.0 | -0.2 | -0.3 | -0.8 | 0.6 | -0.4 | 0.2 | 0.5 | 0.1 | -1.0 | 1.1 | -1.0 | 0.7 |
Locomotion velocity, session 3 | 0.3 | 0.3 | 1.5 | 0.6 | -0.6 | 0.5 | 0.7 | -0.6 | -0.4 | 0.6 | 0.5 | -0.2 | 0.2 | -0.6 | 0.6 | -0.1 | 0.4 | 0.5 | -0.1 | 0.1 | -0.7 | 0.7 | -0.2 | 0.6 | 0.4 | 0.3 | -0.7 | 1.2 | 0.3 | 0.6 | 0.7 | 0.6 | -0.4 | 0.5 | -0.6 | 0.7 |
Locomotion distance, session 7 | 0.3 | 0.4 | 2.0 | 0.0 | -0.0 | 1.4 | 0.1 | -0.0 | 0.2 | 1.0 | 0.8 | 0.2 | -0.5 | -0.0 | 0.1 | 1.0 | 0.8 | 0.8 | 0.5 | -0.1 | -0.4 | 0.4 | 1.2 | 0.2 | 0.7 | 1.0 | -0.3 | 0.6 | -0.7 | 0.8 | 0.8 | 0.8 | 0.2 | -0.1 | -0.2 | 0.5 |
Condit. Reinf. active responses | 0.3 | 0.4 | 1.3 | -1.0 | 1.0 | -0.1 | -0.9 | 0.9 | 0.7 | 0.3 | 0.3 | 0.7 | -0.7 | 0.8 | -0.8 | 1.1 | 0.5 | 0.3 | 0.7 | -0.4 | 0.2 | -0.2 | 0.8 | -0.4 | 0.3 | 0.7 | 0.5 | -0.2 | -1.0 | 0.1 | 0.1 | 0.2 | 0.8 | -0.8 | 0.6 | -0.3 |
Time in open arm after self-admin | 0.3 | 0.3 | 1.4 | -0.1 | 0.1 | 0.6 | -0.3 | 0.3 | 0.6 | 0.5 | 0.9 | 1.0 | -0.9 | 0.0 | 0.1 | 0.8 | 0.7 | 0.9 | 1.0 | -1.2 | 0.2 | -0.2 | 0.4 | 0.5 | 0.8 | 0.8 | 0.3 | -0.1 | -0.1 | 0.5 | 0.3 | 0.5 | 0.7 | -0.6 | 0.5 | -0.0 |
Latency to leave start box in cocaine runway, F | 0.3 | 0.4 | 0.8 | 0.8 | -0.8 | 0.9 | 0.8 | -0.8 | -0.2 | 0.5 | 0.6 | 0.3 | -0.1 | -0.8 | 0.8 | -0.1 | 0.6 | 0.6 | 0.3 | -0.7 | -0.8 | 0.8 | 0.3 | 0.9 | 0.8 | 0.3 | -0.3 | -0.2 | 0.8 | 0.6 | 0.6 | 0.6 | -0.1 | 0.1 | -0.3 | 0.5 |
Mg content in liver | 0.3 | 0.3 | 0.8 | 0.7 | -0.7 | 0.2 | 0.7 | -0.7 | -0.7 | 0.3 | 0.2 | -0.5 | 0.5 | -0.9 | 0.9 | -0.3 | 0.1 | 0.2 | -0.4 | 0.3 | -0.7 | 0.7 | -0.4 | 0.6 | 0.2 | -0.1 | -0.8 | 0.8 | 0.8 | 0.4 | 0.5 | 0.3 | -0.7 | 0.6 | -0.7 | 0.7 |
Std. dev. time between licks in bursts | 0.2 | 0.2 | 1.1 | 0.3 | -0.2 | -0.3 | 0.4 | -0.3 | -0.6 | 0.1 | -0.2 | -0.7 | 0.6 | -0.2 | 0.1 | -0.5 | -0.5 | -0.2 | -0.8 | 1.0 | -0.2 | 0.2 | -0.5 | -0.2 | -0.5 | -0.2 | -0.5 | 0.8 | -0.0 | -0.0 | 0.0 | -0.0 | -0.7 | 0.7 | -0.6 | 0.3 |
Light reinforcement 2 | 0.2 | 0.3 | 0.9 | -0.5 | 0.5 | -0.2 | -0.5 | 0.5 | -0.1 | -0.5 | -0.5 | 0.0 | 0.2 | 0.6 | -0.6 | -0.1 | -0.5 | -0.5 | -0.0 | 0.1 | 0.8 | -0.8 | 0.2 | -0.7 | -0.6 | -0.3 | 0.7 | -1.0 | -0.5 | -0.7 | -0.7 | -0.6 | 0.4 | -0.4 | 0.6 | -0.8 |
Reaction time num false alarms AUC | 0.2 | 0.2 | 0.9 | -0.6 | 0.6 | 0.2 | -0.5 | 0.6 | 0.1 | 0.8 | 0.4 | 0.0 | -0.2 | 0.3 | -0.3 | 1.0 | 0.8 | 0.4 | 0.2 | 0.3 | -0.2 | 0.2 | 0.6 | -0.0 | 0.6 | 0.7 | -0.3 | 0.8 | -0.9 | 0.5 | 0.7 | 0.5 | -0.0 | -0.1 | -0.2 | 0.5 |
Reaction time premature initiation rate | 0.2 | 0.3 | 1.0 | -0.2 | 0.2 | 0.4 | -0.2 | 0.2 | -0.4 | 1.0 | 0.8 | 0.2 | -0.1 | -0.2 | 0.2 | 0.5 | 0.7 | 0.8 | 0.3 | -0.3 | -0.5 | 0.5 | 0.9 | 0.6 | 0.7 | 0.9 | -0.4 | 0.5 | -0.1 | 0.8 | 0.9 | 0.9 | 0.0 | 0.1 | -0.3 | 0.7 |
Conditioned locomotion | 0.2 | 0.3 | 1.2 | -0.0 | -0.0 | -0.9 | -0.1 | 0.1 | 0.0 | -0.7 | -0.6 | -0.2 | 0.2 | 0.2 | -0.2 | -0.8 | -0.7 | -0.6 | -0.3 | 0.3 | 0.7 | -0.7 | -1.1 | -0.4 | -0.8 | -0.6 | 0.3 | 0.2 | 0.2 | -0.7 | -0.8 | -0.6 | -0.0 | 0.1 | 0.3 | -0.5 |
Cocaine response before conditioning | 0.2 | 0.3 | 2.3 | -0.2 | 0.2 | 0.2 | -0.2 | 0.2 | -0.3 | 0.8 | 0.5 | -0.2 | 0.1 | -0.1 | 0.1 | 0.4 | 0.7 | 0.5 | -0.1 | 0.4 | -0.5 | 0.5 | 0.0 | 0.3 | 0.4 | 0.6 | -0.8 | 1.5 | -0.3 | 0.8 | 0.8 | 0.7 | -0.4 | 0.2 | -0.6 | 0.8 |
Pavlov. Cond. change in total contacts | 0.2 | 0.3 | 0.9 | -0.5 | 0.5 | 0.5 | -0.4 | 0.4 | 0.1 | 0.8 | 0.5 | 0.0 | -0.3 | 0.3 | -0.3 | 1.0 | 0.8 | 0.5 | 0.4 | 0.2 | -0.5 | 0.5 | 1.0 | -0.0 | 0.6 | 0.8 | -0.2 | 0.3 | -0.9 | 0.6 | 0.6 | 0.5 | 0.2 | 0.0 | -0.2 | 0.4 |
Intermitt. access day 15 inactive lever presses | 0.2 | 0.2 | 0.5 | -0.1 | 0.1 | -0.3 | -0.3 | 0.2 | 0.6 | -0.6 | -0.1 | 0.6 | -0.5 | 0.2 | -0.1 | -0.4 | -0.3 | -0.1 | 0.5 | -0.7 | 0.6 | -0.6 | -0.4 | -0.1 | -0.1 | -0.3 | 0.7 | -0.6 | 0.3 | -0.5 | -0.6 | -0.3 | 0.7 | -0.6 | 0.7 | -0.7 |
Intermittent access terminal intake (last 3 days) | 0.2 | 0.2 | 1.1 | -0.5 | 0.6 | -0.4 | -0.6 | 0.6 | 0.3 | -0.4 | -0.3 | 0.1 | -0.1 | 0.7 | -0.7 | -0.1 | -0.2 | -0.3 | 0.1 | 0.1 | 0.6 | -0.6 | 0.2 | -0.6 | -0.3 | -0.1 | 0.5 | -0.4 | -1.0 | -0.5 | -0.4 | -0.4 | 0.3 | -0.2 | 0.4 | -0.5 |
Incentive Sensitization - Responses | 0.2 | 0.2 | 0.6 | -0.5 | 0.5 | -0.7 | -0.4 | 0.4 | -0.3 | -0.1 | -0.5 | -0.5 | 0.5 | 0.4 | -0.5 | -0.3 | -0.2 | -0.5 | -0.5 | 0.7 | 0.1 | -0.1 | 0.2 | -0.6 | -0.4 | -0.2 | -0.0 | 0.3 | -0.8 | -0.3 | -0.2 | -0.3 | -0.2 | 0.2 | -0.1 | -0.1 |
Incentive Sensitization - Breakpoint | 0.2 | 0.2 | 0.7 | -0.5 | 0.6 | -0.7 | -0.4 | 0.5 | -0.4 | -0.2 | -0.6 | -0.5 | 0.5 | 0.5 | -0.5 | -0.4 | -0.3 | -0.6 | -0.5 | 0.8 | 0.1 | -0.1 | 0.1 | -0.7 | -0.5 | -0.3 | -0.0 | 0.3 | -0.8 | -0.3 | -0.2 | -0.4 | -0.3 | 0.2 | -0.1 | -0.1 |
Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.7 | 0.6 | -0.6 | 0.3 | 0.6 | -0.6 | -0.8 | 0.1 | -0.1 | -0.7 | 0.7 | -0.4 | 0.4 | -0.5 | -0.2 | -0.1 | -0.6 | 0.6 | -0.5 | 0.5 | -0.2 | 0.2 | -0.1 | -0.2 | -0.6 | 0.4 | 0.0 | 0.2 | 0.3 | 0.1 | -0.7 | 0.9 | -0.7 | 0.5 |
Short access day 1 total inactive lever presses | 0.2 | 0.3 | 0.6 | -0.2 | 0.2 | -0.6 | -0.3 | 0.3 | -0.4 | -0.7 | -0.7 | -0.4 | 0.6 | 0.3 | -0.3 | -0.6 | -0.7 | -0.7 | -0.5 | 0.5 | 0.6 | -0.6 | -0.4 | -0.5 | -0.7 | -0.7 | 0.2 | -0.3 | -0.1 | -0.7 | -0.6 | -0.6 | -0.2 | 0.3 | 0.1 | -0.4 |
Locomotion velocity, session 2 | 0.2 | 0.2 | 1.2 | -0.8 | 0.8 | 0.3 | -0.7 | 0.7 | 0.3 | 0.4 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 1.0 | 0.4 | 0.3 | 0.4 | -0.2 | -0.1 | 0.1 | 1.1 | -0.1 | 0.4 | 0.6 | 0.2 | -0.7 | -0.6 | 0.2 | 0.3 | 0.3 | 0.4 | -0.3 | 0.2 | 0.0 |
Condit. Reinf. lever presses | 0.2 | 0.2 | 1.0 | -0.8 | 0.8 | -0.3 | -0.8 | 0.8 | 0.4 | -0.1 | -0.2 | 0.2 | -0.3 | 0.8 | -0.8 | 0.6 | 0.0 | -0.2 | 0.2 | 0.2 | 0.5 | -0.5 | 0.1 | -0.7 | -0.2 | 0.2 | 0.4 | 0.3 | -1.0 | -0.3 | -0.2 | -0.2 | 0.5 | -0.5 | 0.5 | -0.4 |
Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 0.9 | 0.1 | -0.1 | 0.3 | 0.0 | -0.1 | 0.5 | 0.3 | 0.5 | 0.8 | -0.6 | -0.2 | 0.3 | 0.4 | 0.4 | 0.5 | 0.6 | -0.9 | 0.1 | -0.1 | 0.1 | 0.5 | 0.5 | 0.4 | 0.2 | 0.1 | 0.4 | 0.3 | 0.2 | 0.4 | 0.5 | -0.4 | 0.3 | 0.0 |
Locomotion velocity, NPP test | 0.2 | 0.3 | 1.0 | -0.5 | 0.5 | 0.7 | -0.5 | 0.5 | -0.0 | 1.0 | 0.7 | 0.2 | -0.3 | 0.1 | -0.0 | 1.0 | 1.0 | 0.7 | 0.4 | 0.1 | -0.4 | 0.4 | 0.7 | 0.3 | 0.8 | 0.9 | -0.4 | 0.6 | -0.6 | 0.8 | 0.9 | 0.8 | -0.0 | -0.0 | -0.3 | 0.6 |
Pavlov. Cond. magazine entry latency | 0.2 | 0.3 | 1.4 | 0.3 | -0.3 | 0.2 | 0.3 | -0.3 | -0.6 | 0.6 | 0.4 | -0.3 | 0.3 | -0.7 | 0.8 | -0.2 | 0.2 | 0.4 | -0.3 | 0.2 | -0.3 | 0.3 | 0.1 | 0.6 | 0.3 | 0.3 | -0.7 | 1.2 | 0.3 | 0.6 | 0.7 | 0.6 | -0.5 | 0.6 | -0.7 | 0.8 |
Pavlov. Cond. index score | 0.2 | 0.3 | 0.9 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 | 0.4 | 0.8 | 0.8 | 0.7 | -0.7 | 0.0 | 0.1 | 0.9 | 0.7 | 0.8 | 0.7 | -0.6 | 0.1 | -0.1 | 0.7 | 0.3 | 0.6 | 0.9 | 0.0 | 0.9 | -0.5 | 0.5 | 0.6 | 0.7 | 0.5 | -0.4 | 0.2 | 0.2 |
Pavlov. Cond. lever-magazine prob. diff. | 0.2 | 0.3 | 0.9 | -0.3 | 0.3 | 0.4 | -0.3 | 0.3 | 0.3 | 0.7 | 0.7 | 0.7 | -0.6 | -0.0 | 0.2 | 0.8 | 0.7 | 0.7 | 0.6 | -0.6 | 0.2 | -0.2 | 0.6 | 0.3 | 0.6 | 0.8 | 0.0 | 0.9 | -0.3 | 0.5 | 0.6 | 0.6 | 0.4 | -0.4 | 0.2 | 0.2 |
Bone: post-yield work | 0.2 | 0.3 | 1.3 | 0.5 | -0.5 | -0.4 | 0.5 | -0.5 | -0.6 | -0.2 | -0.3 | -0.6 | 0.7 | -0.5 | 0.6 | -0.9 | -0.4 | -0.3 | -0.7 | 0.7 | -0.3 | 0.3 | -1.2 | 0.0 | -0.4 | -0.5 | -0.5 | 1.1 | 0.5 | -0.1 | -0.1 | -0.2 | -0.6 | 0.7 | -0.5 | 0.2 |
Delta ambulatory time before/after self-admin | 0.2 | 0.2 | 0.5 | 0.0 | -0.1 | 0.0 | 0.0 | -0.1 | -0.2 | -0.6 | -0.6 | -0.2 | 0.3 | 0.3 | -0.3 | -0.6 | -0.7 | -0.6 | -0.4 | 0.3 | 0.5 | -0.5 | -0.4 | -0.5 | -0.7 | -0.4 | 0.3 | -0.4 | -0.3 | -0.6 | -0.6 | -0.6 | -0.0 | 0.1 | 0.2 | -0.5 |
Time to tail flick, vehicle, after self-admin | 0.2 | 0.3 | 1.2 | -0.4 | 0.4 | 0.3 | -0.3 | 0.3 | 0.6 | 0.6 | 0.6 | 0.5 | -0.7 | 0.3 | -0.3 | 0.9 | 0.6 | 0.6 | 0.7 | -0.4 | -0.4 | 0.4 | 1.1 | -0.0 | 0.4 | 0.9 | 0.2 | -0.4 | -0.6 | 0.4 | 0.3 | 0.5 | 0.6 | -0.4 | 0.2 | 0.1 |
Distance moved, locomotor task time 1 | 0.2 | 0.2 | 0.6 | -0.7 | 0.7 | 0.1 | -0.6 | 0.6 | 0.4 | 0.1 | 0.1 | 0.4 | -0.4 | 0.7 | -0.7 | 0.6 | 0.3 | 0.1 | 0.3 | -0.0 | 0.2 | -0.2 | 0.7 | -0.4 | 0.1 | 0.4 | 0.4 | -0.6 | -0.8 | -0.0 | -0.1 | 0.0 | 0.4 | -0.7 | 0.4 | -0.3 |
Epididymis fat weight | 0.1 | 0.3 | 1.1 | -0.1 | 0.0 | -0.0 | -0.0 | -0.0 | -0.2 | 0.8 | 0.8 | 0.2 | -0.2 | -0.4 | 0.5 | 0.5 | 0.9 | 0.8 | 0.4 | -0.3 | -0.8 | 0.8 | -0.2 | 0.7 | 0.8 | 0.7 | -0.5 | 1.1 | 0.3 | 0.7 | 0.7 | 0.8 | -0.1 | 0.2 | -0.2 | 0.6 |
Parametrial fat weight | 0.1 | 0.2 | 1.0 | 0.7 | -0.7 | 0.5 | 0.7 | -0.7 | -0.5 | -0.1 | 0.1 | 0.1 | 0.3 | -0.6 | 0.6 | -0.4 | -0.1 | 0.1 | -0.1 | -0.4 | -0.3 | 0.3 | -0.3 | 0.5 | 0.2 | -0.2 | -0.1 | -0.3 | 1.0 | 0.1 | -0.0 | 0.0 | -0.1 | -0.0 | -0.2 | 0.1 |
Reaction time premature initiations | 0.1 | 0.1 | 0.6 | -0.0 | 0.0 | -0.2 | -0.0 | 0.0 | -0.8 | 0.3 | -0.0 | -0.5 | 0.6 | -0.3 | 0.2 | -0.3 | -0.0 | -0.0 | -0.5 | 0.5 | -0.4 | 0.4 | 0.0 | 0.1 | -0.1 | 0.0 | -0.5 | 0.4 | 0.1 | 0.3 | 0.4 | 0.2 | -0.4 | 0.6 | -0.6 | 0.5 |
Total sessions with >9 infusions | 0.1 | 0.1 | 0.5 | 0.1 | -0.1 | 0.7 | 0.0 | -0.0 | -0.1 | 0.5 | 0.5 | 0.3 | -0.2 | -0.1 | 0.2 | 0.1 | 0.6 | 0.5 | 0.4 | -0.3 | -0.4 | 0.4 | 0.4 | 0.4 | 0.6 | 0.6 | -0.2 | 0.2 | -0.3 | 0.5 | 0.5 | 0.5 | 0.1 | 0.1 | -0.1 | 0.4 |
Number of responses in last shaping day | 0.1 | 0.1 | 0.4 | -0.0 | 0.0 | -0.6 | -0.0 | 0.0 | -0.3 | -0.5 | -0.5 | -0.3 | 0.4 | 0.2 | -0.3 | -0.4 | -0.5 | -0.5 | -0.4 | 0.5 | 0.3 | -0.3 | -0.3 | -0.4 | -0.4 | -0.5 | 0.1 | -0.3 | -0.4 | -0.4 | -0.4 | -0.5 | -0.2 | 0.3 | -0.0 | -0.2 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.9 | -0.6 | 0.6 | -0.1 | -0.5 | 0.5 | 0.2 | -0.0 | -0.2 | -0.1 | -0.0 | 0.7 | -0.7 | 0.4 | 0.0 | -0.2 | 0.1 | 0.4 | 0.2 | -0.2 | 0.5 | -0.6 | -0.2 | 0.1 | 0.3 | -0.3 | -1.0 | -0.2 | -0.2 | -0.2 | 0.2 | -0.2 | 0.2 | -0.3 |
Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.2 | 0.1 | -0.0 | 0.2 | 0.1 | -0.1 | -0.5 | 0.2 | -0.0 | -0.4 | 0.4 | -0.2 | 0.2 | -0.0 | -0.0 | -0.0 | -0.4 | 0.5 | -0.3 | 0.3 | 0.4 | 0.1 | 0.0 | -0.0 | -0.3 | -0.2 | 0.1 | 0.2 | 0.3 | 0.2 | -0.4 | 0.4 | -0.5 | 0.4 |
Total locomotion distance, hab. session 2 | 0.1 | 0.1 | 0.5 | -0.7 | 0.7 | 0.2 | -0.7 | 0.7 | 0.2 | 0.1 | -0.0 | 0.2 | -0.2 | 0.5 | -0.5 | 0.6 | 0.2 | -0.0 | 0.2 | 0.1 | 0.3 | -0.3 | 0.6 | -0.4 | 0.1 | 0.3 | 0.3 | -0.4 | -0.7 | -0.1 | -0.0 | -0.0 | 0.3 | -0.4 | 0.2 | -0.2 |
Locomotion velocity, hab. session 2 | 0.1 | 0.1 | 0.5 | -0.7 | 0.7 | 0.1 | -0.7 | 0.7 | 0.2 | 0.0 | -0.1 | 0.1 | -0.1 | 0.5 | -0.6 | 0.5 | 0.1 | -0.1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.6 | -0.4 | -0.0 | 0.2 | 0.3 | -0.5 | -0.7 | -0.1 | -0.1 | -0.1 | 0.2 | -0.3 | 0.2 | -0.2 |
Novelty place preference | 0.1 | 0.2 | 0.8 | -0.6 | 0.6 | 0.2 | -0.5 | 0.5 | 0.3 | 0.1 | 0.1 | 0.3 | -0.3 | 0.5 | -0.4 | 0.7 | 0.1 | 0.1 | 0.3 | -0.1 | -0.1 | 0.1 | 0.9 | -0.3 | 0.1 | 0.3 | 0.4 | -0.7 | -0.6 | 0.0 | -0.0 | 0.0 | 0.3 | -0.3 | 0.3 | -0.2 |
Time in novel zone, NPP test | 0.1 | 0.1 | 0.5 | -0.4 | 0.4 | 0.3 | -0.4 | 0.4 | 0.1 | 0.2 | 0.1 | 0.1 | -0.2 | 0.2 | -0.2 | 0.5 | 0.1 | 0.1 | 0.2 | -0.1 | -0.2 | 0.2 | 0.7 | -0.1 | 0.1 | 0.3 | 0.2 | -0.4 | -0.4 | 0.1 | 0.1 | 0.1 | 0.1 | -0.2 | 0.1 | 0.0 |
Total zone transitions, NPP test | 0.1 | 0.1 | 0.2 | -0.1 | 0.1 | 0.4 | -0.1 | 0.0 | -0.3 | 0.4 | 0.3 | -0.1 | 0.1 | -0.2 | 0.2 | 0.4 | 0.4 | 0.3 | -0.0 | 0.3 | -0.3 | 0.3 | 0.4 | 0.1 | 0.3 | 0.3 | -0.3 | 0.2 | -0.2 | 0.4 | 0.5 | 0.4 | -0.2 | 0.3 | -0.4 | 0.4 |
Pavlov. Cond. response bias | 0.1 | 0.2 | 1.5 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | -0.2 | 0.7 | 0.6 | 0.1 | -0.1 | -0.3 | 0.4 | 0.3 | 0.6 | 0.6 | 0.2 | -0.1 | -0.2 | 0.2 | 0.2 | 0.4 | 0.5 | 0.6 | -0.4 | 1.2 | -0.0 | 0.6 | 0.7 | 0.6 | -0.1 | 0.2 | -0.3 | 0.5 |
Bone: cortical porosity | 0.1 | 0.1 | 0.2 | 0.2 | -0.2 | -0.3 | 0.1 | -0.1 | -0.3 | -0.3 | -0.3 | -0.4 | 0.4 | -0.1 | 0.1 | -0.5 | -0.4 | -0.3 | -0.4 | 0.3 | 0.1 | -0.1 | -0.4 | -0.1 | -0.4 | -0.4 | -0.1 | 0.1 | 0.2 | -0.2 | -0.2 | -0.2 | -0.3 | 0.1 | -0.2 | -0.0 |
Bone: cortical porosity | 0.1 | 0.1 | 0.3 | -0.5 | 0.5 | -0.3 | -0.5 | 0.5 | 0.1 | -0.2 | -0.3 | -0.1 | 0.0 | 0.5 | -0.5 | 0.1 | -0.2 | -0.3 | -0.1 | 0.2 | 0.4 | -0.4 | 0.1 | -0.5 | -0.4 | -0.0 | 0.3 | -0.1 | -0.5 | -0.3 | -0.3 | -0.3 | 0.1 | -0.3 | 0.2 | -0.3 |
Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | 0.1 | -0.1 | 0.1 | -0.1 | 0.5 | -0.1 | -0.5 | 0.2 | -0.1 | 0.1 | 0.2 | 0.2 | -0.1 | -0.2 | 0.4 | -0.3 | 0.3 | 0.4 | -0.0 | 0.1 | 0.2 | -0.4 | 0.4 | -0.3 | 0.3 | 0.4 | 0.3 | -0.4 | 0.4 | -0.4 | 0.4 |
Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | 0.2 | 0.4 | -0.4 | -0.3 | 0.1 | 0.2 | -0.2 | 0.2 | -0.5 | 0.5 | -0.6 | 0.2 | 0.2 | -0.1 | 0.1 | -0.3 | 0.3 | -0.3 | 0.3 | 0.2 | 0.0 | -0.4 | 0.4 | 0.3 | 0.2 | 0.3 | 0.2 | -0.3 | 0.2 | -0.3 | 0.4 |
Time in open arm before self-admin | 0.1 | 0.1 | 0.4 | 0.1 | -0.0 | 0.7 | -0.0 | 0.0 | -0.2 | 0.6 | 0.3 | -0.2 | 0.1 | -0.3 | 0.3 | 0.6 | 0.2 | 0.3 | 0.0 | 0.1 | -0.3 | 0.3 | 0.5 | 0.3 | 0.3 | 0.4 | -0.4 | 0.2 | -0.1 | 0.5 | 0.6 | 0.5 | -0.2 | 0.3 | -0.4 | 0.5 |
Ambulatory time after self-admin | 0.1 | 0.1 | 0.5 | -0.1 | 0.1 | 0.5 | -0.0 | 0.0 | 0.2 | 0.6 | 0.4 | 0.2 | -0.3 | 0.1 | -0.1 | 0.7 | 0.5 | 0.4 | 0.4 | -0.2 | -0.4 | 0.4 | 0.5 | 0.1 | 0.4 | 0.6 | -0.1 | 0.1 | -0.4 | 0.4 | 0.4 | 0.4 | 0.1 | -0.2 | -0.0 | 0.3 |
Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.8 | 0.1 | -0.1 | 0.1 | 0.2 | -0.2 | -0.5 | 0.1 | -0.2 | -0.6 | 0.5 | -0.2 | 0.2 | -0.3 | -0.2 | -0.2 | -0.7 | 0.9 | -0.2 | 0.2 | -0.0 | -0.1 | -0.3 | -0.2 | -0.5 | -0.0 | 0.1 | 0.0 | 0.1 | -0.0 | -0.6 | 0.5 | -0.6 | 0.4 |
Rest time, locomotor task time 2 | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | -0.0 | -0.4 | 0.4 | 0.3 | -0.0 | 0.1 | 0.2 | -0.3 | 0.3 | -0.3 | -0.0 | 0.2 | 0.1 | 0.4 | -0.4 | 0.2 | -0.2 | 0.1 | -0.2 | 0.2 | 0.2 | 0.4 | -0.0 | -0.6 | -0.1 | -0.1 | -0.1 | 0.6 | -0.3 | 0.5 | -0.4 |
Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.4 | 0.4 | -0.4 | -0.2 | 0.4 | -0.4 | -0.5 | -0.4 | -0.4 | -0.5 | 0.6 | -0.1 | 0.0 | -0.4 | -0.7 | -0.4 | -0.7 | 0.5 | -0.0 | 0.0 | -0.1 | -0.1 | -0.6 | -0.5 | -0.1 | -0.5 | 0.4 | -0.2 | -0.3 | -0.3 | -0.5 | 0.2 | -0.3 | -0.0 |
K content in liver | 0.1 | 0.1 | 0.4 | 0.0 | -0.0 | 0.1 | 0.1 | -0.1 | -0.0 | 0.3 | 0.3 | 0.2 | -0.1 | -0.3 | 0.3 | 0.3 | 0.4 | 0.3 | 0.2 | -0.2 | -0.4 | 0.4 | -0.1 | 0.3 | 0.4 | 0.2 | -0.2 | 0.6 | 0.2 | 0.3 | 0.3 | 0.2 | -0.0 | 0.0 | -0.1 | 0.2 |
Stereotopy head waving duration, day 3 | 0.0 | 0.0 | 0.2 | -0.0 | 0.0 | -0.4 | -0.1 | 0.1 | -0.1 | -0.1 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.3 | 0.0 | 0.0 | -0.1 | -0.2 | -0.2 | 0.2 | -0.3 | 0.2 | 0.1 | -0.2 | -0.0 | -0.2 | 0.5 | -0.0 | -0.0 | 0.0 | -0.1 | -0.1 | -0.0 | 0.0 |
Novel to familiar place preference ratio | 0.0 | 0.0 | 0.5 | -0.3 | 0.3 | 0.3 | -0.2 | 0.2 | -0.0 | 0.2 | 0.1 | 0.0 | -0.0 | 0.1 | -0.1 | 0.4 | 0.1 | 0.1 | 0.1 | 0.0 | -0.3 | 0.3 | 0.7 | -0.0 | 0.1 | 0.2 | 0.1 | -0.4 | -0.3 | 0.2 | 0.1 | 0.1 | -0.0 | -0.0 | -0.0 | 0.1 |
Bone: minimum diameter | 0.0 | 0.0 | 0.1 | 0.3 | -0.2 | 0.1 | 0.3 | -0.3 | -0.2 | -0.2 | -0.3 | -0.2 | 0.3 | 0.1 | -0.1 | -0.1 | -0.3 | -0.3 | -0.3 | 0.3 | 0.1 | -0.1 | -0.2 | -0.2 | -0.2 | -0.3 | 0.0 | -0.2 | 0.0 | -0.2 | -0.2 | -0.2 | -0.1 | 0.2 | -0.0 | -0.1 |
Distance traveled after self-admin | 0.0 | 0.0 | 0.2 | -0.1 | 0.1 | 0.2 | -0.1 | 0.1 | -0.0 | 0.3 | 0.1 | -0.2 | 0.0 | 0.1 | -0.1 | 0.4 | 0.2 | 0.1 | 0.0 | 0.2 | -0.4 | 0.4 | 0.4 | -0.0 | 0.2 | 0.3 | -0.2 | -0.2 | -0.3 | 0.2 | 0.3 | 0.2 | -0.2 | 0.2 | -0.2 | 0.3 |
Diff in mean of infusions in LGA sessions | 0.0 | 0.0 | 0.4 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | -0.3 | 0.1 | -0.0 | -0.3 | 0.2 | -0.1 | 0.0 | -0.2 | 0.1 | -0.0 | -0.2 | 0.3 | -0.2 | 0.2 | -0.3 | -0.0 | -0.0 | 0.1 | -0.3 | 0.6 | -0.1 | 0.1 | 0.2 | 0.1 | -0.2 | 0.2 | -0.3 | 0.3 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.