Hub : Genes

Ppp2r2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	ENSRNOT00000099993	0.03	0.03	1.0e-03	0.03	0.03	0.03	0.03	1.8e-04	4.9e-04	3.7e-04	1.9e-04
2	Adipose	alternative TSS	ENSRNOT00000099993	0.04	0.03	4.3e-04	0.03	0.03	0.03	0.03	9.6e-05	2.2e-04	1.5e-04	1.1e-04
3	Adipose	gene expression	ENSRNOG00000011158	0.07	0.05	6.1e-07	0.06	0.05	0.05	0.05	3.1e-07	1.3e-06	4.9e-06	2.3e-06
4	Adipose	isoform ratio	ENSRNOT00000099993	0.05	0.04	8.7e-05	0.04	0.04	0.04	0.04	1.5e-05	3.4e-05	2.4e-05	2.1e-05
5	Brain	gene expression	ENSRNOG00000011158	0.03	0.02	9.7e-03	0.03	0.02	0.02	0.02	1.5e-03	1.1e-02	4.5e-03	3.8e-03
6	IL	alternative TSS	ENSRNOT00000097094	0.22	0.15	8.2e-03	0.07	0.07	0.05	0.04	8.4e-03	1.0e-02	2.2e-02	4.4e-02
7	NAcc	intron excision ratio	chr15:41261896:41263615	0.06	0.05	1.8e-03	0.03	0.02	0.02	0.02	5.6e-03	1.9e-02	1.9e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.4	1.3	2.9	-1.0	-1.0	-1.0	-1.0	-1.7	-1.3	0.6
BMI without tail	0.6	1.3	2.2	1.3	1.3	1.3	1.3	-0.2	0.1	-1.5
Body weight	0.1	0.5	0.7	-0.8	-0.8	-0.8	-0.8	-0.4	0.2	0.6
Epididymis fat weight	1.4	3.4	4.5	1.9	1.9	2.1	1.9	1.4	1.4	-1.9
Glucose	0.4	0.6	1.6	0.5	0.5	0.5	0.5	-1.3	-1.0	-0.5
Heart weight	0.6	0.8	1.2	1.0	1.0	0.9	1.0	0.5	1.1	-0.9
Left kidney weight	0.0	0.1	0.7	-0.1	-0.1	-0.2	-0.1	-0.0	0.8	0.0
Right kidney weight	1.1	3.2	8.7	1.3	1.3	1.3	1.3	2.2	3.0	-1.3
Tail length	1.4	4.3	6.3	2.0	2.0	1.9	2.0	2.1	2.5	-1.9
Length with tail	0.2	0.6	2.8	-0.1	-0.1	-0.1	-0.1	1.1	1.7	0.1
Length without tail	2.2	4.8	6.7	-2.6	-2.6	-2.5	-2.6	-1.0	-0.5	2.4
Liver weight, left	0.9	1.5	2.0	-1.1	-1.1	-1.1	-1.1	-1.4	-1.4	1.3
Liver weight, right	1.0	1.6	1.9	-1.3	-1.3	-1.3	-1.3	-1.2	-1.4	1.1
Parametrial fat weight	2.5	4.8	5.9	2.4	2.4	2.4	2.4	2.0	1.1	-2.2
Retroperitoneal fat weight	0.3	0.9	2.0	1.0	1.0	1.0	1.0	0.0	0.4	-1.4
Intraocular pressure	0.4	0.6	0.7	0.8	0.8	0.8	0.8	0.8	0.7	-0.7
Extensor digitorum longus weight	11.1	44.7	52.0	-7.2	-7.2	-7.2	-7.2	-5.2	-5.2	7.2
Soleus weight	1.0	2.9	3.3	-1.7	-1.7	-1.7	-1.7	-1.7	-1.8	1.7
Tibialis anterior weight	7.1	24.4	29.0	-5.4	-5.4	-5.4	-5.4	-3.7	-3.6	5.4
Tibia length	2.3	6.6	15.6	1.7	1.7	1.7	1.7	4.0	3.9	-1.9
Number of licking bursts	0.2	0.2	0.7	-0.2	-0.2	-0.2	-0.2	-0.8	-0.7	-0.1
Food consumed during 24 hour testing period	1.2	1.5	2.9	1.0	1.0	1.0	1.0	1.5	1.7	-1.1
Times rat made contact with spout	1.0	1.1	1.6	1.2	1.2	1.1	1.2	0.5	0.6	-1.3
Mean time between licks in bursts	1.9	2.6	3.3	1.6	1.6	1.6	1.6	1.5	1.6	-1.8
Mean num. licks in bursts	0.7	0.9	1.3	0.9	0.9	0.9	0.9	1.2	1.0	-0.7
Std. dev. time between licks in bursts	3.0	3.6	6.8	1.6	1.6	1.6	1.6	2.6	2.6	-1.5
Water consumed over 24 hours	0.3	0.4	0.6	-0.8	-0.8	-0.8	-0.8	-0.1	-0.2	0.7
Indifference point 0 sec	4.4	7.2	17.3	1.9	1.9	2.0	1.9	4.2	3.8	-1.7
Indifference point AUC	2.1	2.5	5.6	-1.4	-1.4	-1.3	-1.4	-1.6	-2.4	1.5
Indifference point function ln k	0.7	1.0	3.1	0.6	0.6	0.7	0.6	1.3	1.8	-0.9
Indifference point function log k	0.7	1.0	3.1	0.6	0.6	0.7	0.6	1.3	1.8	-0.9
Delay discounting total patch changes 0 sec	4.0	6.4	17.3	1.7	1.7	1.8	1.7	4.2	3.7	-1.5
Delay discounting total patch changes 12 sec	0.5	0.7	2.8	0.4	0.4	0.5	0.4	1.7	1.1	-0.2
Delay discounting total patch changes 18 sec	1.0	1.3	3.0	1.0	1.0	1.2	1.0	1.7	1.0	-0.8
Delay discounting total patch changes 24 sec	0.7	0.9	3.4	0.1	0.1	0.2	0.1	1.9	1.6	-0.1
Delay discounting total patch changes 6 sec	0.5	0.8	3.1	0.6	0.6	0.6	0.6	1.7	0.9	-0.3
Delay discounting time to switch 0 sec	0.2	0.2	0.4	0.5	0.5	0.4	0.5	0.5	0.6	-0.5
Delay discounting water rate 0 sec	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.2	0.1	0.6
Delay discounting water rate 12 sec	0.2	0.3	0.4	-0.6	-0.6	-0.5	-0.6	-0.0	0.4	0.4
Delay discounting water rate 18 sec	1.2	1.6	1.9	-1.3	-1.3	-1.4	-1.3	-1.3	-0.9	1.3
Delay discounting water rate 24 sec	0.1	0.2	0.7	0.2	0.2	0.3	0.2	-0.8	-0.6	-0.2
Delay discounting water rate 6 sec	1.0	1.4	2.0	-1.4	-1.4	-1.4	-1.4	-0.4	-0.2	1.4
Locomotor activity	1.2	1.9	3.1	-1.3	-1.3	-1.4	-1.3	1.2	1.8	1.2
Locomotor testing distance	1.4	2.4	9.2	0.2	0.2	0.1	0.2	2.7	3.0	-0.3
Locomotor testing rearing	2.4	3.8	13.3	0.7	0.7	0.7	0.7	3.2	3.6	-0.7
Light reinforcement 1	2.5	4.7	6.0	2.5	2.5	2.4	2.5	1.1	1.2	-2.4
Light reinforcement 2	0.8	1.1	1.4	1.2	1.2	1.1	1.2	-0.4	-0.8	-1.1
Reaction time number correct	0.6	0.8	2.2	-0.6	-0.6	-0.6	-0.6	-1.1	-1.5	0.9
Reaction time mean minus median	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.3	0.1	0.6
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	-0.2	0.1	0.3
Reaction time num false alarms	0.1	0.2	0.5	0.3	0.3	0.3	0.3	0.7	0.7	-0.2
Reaction time num false alarms AUC	0.2	0.2	0.6	0.4	0.4	0.3	0.4	0.7	0.6	-0.2
Reaction time trials correct on left	0.6	0.8	2.2	-0.6	-0.6	-0.6	-0.6	-1.1	-1.5	0.9
Reaction time trials on left	0.4	0.6	2.0	-0.5	-0.5	-0.4	-0.5	-1.0	-1.4	0.7
Reaction time mean	0.1	0.2	0.3	-0.4	-0.4	-0.5	-0.4	0.0	-0.1	0.5
Reaction time mean AUC	0.3	0.3	0.6	-0.6	-0.6	-0.7	-0.6	-0.1	-0.1	0.8
Median of all reaction times	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.2	0.0	-0.2	0.5
Reaction time omissions	1.3	1.7	2.1	1.4	1.4	1.4	1.4	1.3	0.9	-1.2
Reaction time false alarm rate	0.5	0.7	1.3	0.7	0.7	0.6	0.7	1.0	1.2	-0.7
Reaction time premature initiation rate	0.9	1.2	1.4	-1.2	-1.2	-1.2	-1.2	-1.1	-1.0	0.9
Reaction time premature initiations	1.6	2.3	3.1	-1.4	-1.4	-1.4	-1.4	-1.7	-1.8	1.4
Std. dev. reaction times	0.1	0.1	0.2	-0.4	-0.4	-0.5	-0.4	0.1	-0.0	0.5
Reaction time trials completed	0.4	0.6	2.0	-0.5	-0.5	-0.4	-0.5	-1.0	-1.4	0.7
Reaction time trials AUC	0.4	0.6	2.0	-0.5	-0.5	-0.4	-0.5	-0.9	-1.4	0.8
Social response proportion	0.7	0.8	3.7	-0.0	-0.0	-0.1	-0.0	-1.9	-1.3	-0.3
Social responses	3.0	3.9	6.0	2.3	2.3	2.2	2.3	0.2	1.2	-2.4
Social time	0.8	1.1	3.0	0.9	0.9	1.0	0.9	0.5	1.7	-1.0
Conditioned locomotion	0.3	0.3	1.0	-0.1	-0.1	-0.1	-0.1	-1.0	-1.0	0.3
Cocaine response after cond. corrected	1.9	2.1	6.2	-0.8	-0.8	-0.8	-0.8	-2.3	-2.5	0.9
Cocaine response after cond. not corrected	1.2	1.4	3.7	-0.6	-0.6	-0.7	-0.6	-1.8	-1.9	0.8
Cocaine response before conditioning	1.1	1.4	4.1	0.7	0.7	0.7	0.7	1.8	2.0	-0.7
Saline control response	0.7	0.9	2.0	0.6	0.6	0.7	0.6	1.4	1.4	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	0.5	0.5	0.5	0.5	0.6	0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.4	-0.4	-0.4	-0.4	-0.6	-0.8	0.4
Condit. Reinf. active responses	0.8	1.2	1.3	1.1	1.1	1.1	1.1	1.0	1.1	-1.0
Condit. Reinf. inactive responses	2.4	3.0	3.5	1.8	1.8	1.8	1.8	1.6	1.9	-1.6
Condit. Reinf. lever presses	0.6	0.8	2.8	0.2	0.2	0.3	0.2	1.5	1.7	-0.4
Condit. Reinf. lever reinforcers received	0.7	1.0	1.3	1.0	1.0	1.0	1.0	1.0	1.1	-0.9
Pavlov. Cond. lever latency	0.5	0.7	0.9	0.9	0.9	0.9	0.9	-0.7	-0.7	-0.8
Pavlov. Cond. magazine entry latency	0.5	0.6	2.1	0.3	0.3	0.3	0.3	1.2	1.4	-0.5
Pavlov. Cond. change in total contacts	1.2	1.6	2.3	-1.5	-1.5	-1.5	-1.5	-0.0	0.1	1.4
Pavlov. Cond. index score	0.5	0.7	1.0	-0.8	-0.8	-0.8	-0.8	0.8	1.0	0.6
Pavlov. Cond. latency score	0.5	0.6	1.6	-0.6	-0.6	-0.6	-0.6	1.0	1.3	0.4
Pavlov. Cond. lever contacts	0.7	0.9	1.2	-0.9	-0.9	-0.9	-0.9	1.1	1.1	0.8
Pavlov. Cond. magazine entry number	0.5	0.6	2.3	-0.4	-0.4	-0.3	-0.4	-1.1	-1.5	0.6
Pavlov. Cond. intertrial magazine entries	5.3	6.8	8.3	2.8	2.8	2.9	2.8	2.1	2.0	-2.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.8	-0.9	-0.9	-0.9	-0.9	0.6	0.8	0.6
Pavlov. Cond. response bias	0.7	1.0	1.3	-1.0	-1.0	-1.0	-1.0	1.0	1.1	0.8
Conditioned reinforcement - actives	1.7	1.7	2.1	1.5	1.5	1.5	1.5	0.6	0.8	-1.4
Conditioned reinforcement - inactives	3.5	3.9	4.5	2.0	2.0	2.0	2.0	2.1	2.1	-1.9
Conditioned locomotion	0.7	0.9	1.1	1.1	1.1	1.1	1.1	0.7	0.5	-0.9
Intermittent access intake day 1-15 change	0.7	0.7	1.1	0.9	0.9	1.1	0.9	0.8	0.5	-0.7
Intermittent access intake escalation	0.3	0.3	0.4	0.6	0.6	0.6	0.6	0.5	0.2	-0.4
Intermittent access intake escalation 2	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.1	0.2	-0.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	-0.2	-0.3	-0.1
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.3	0.1	-0.1
Intermitt. access escalation Index	0.3	0.3	0.3	-0.5	-0.5	-0.5	-0.5	-0.5	-0.6	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.1	0.3	0.3	0.2	0.3	-0.2	-0.0	-0.3
Intermittent access day 15 total infusions	0.2	0.3	0.4	0.6	0.6	0.6	0.6	-0.1	-0.2	-0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.6	0.1	0.1	0.1	0.1	-0.8	-0.7	0.0
Intermittent access total infusions	0.3	0.3	0.4	0.7	0.7	0.7	0.7	-0.5	-0.3	-0.5
Intermittent access day 1 locomotion	1.0	1.0	1.5	1.0	1.0	0.9	1.0	0.7	1.2	-1.0
Intermittent access day 15 total locomotion	1.0	1.0	1.4	1.2	1.2	1.2	1.2	0.3	0.6	-1.1
Intermittent access total locomotion	0.5	0.6	0.7	0.8	0.8	0.8	0.8	0.4	0.8	-0.7
Intermittent access standard deviation	0.3	0.3	0.4	0.6	0.6	0.6	0.6	0.3	0.5	-0.6
Cocaine induced anxiety	0.6	0.7	1.6	-0.6	-0.6	-0.6	-0.6	1.3	0.9	0.8
Post-drug Anxiety	1.4	1.5	2.1	1.2	1.2	1.2	1.2	1.4	1.4	-1.1
Baseline Anxiety	1.8	1.8	3.1	1.5	1.5	1.5	1.5	0.4	1.0	-1.7
Lifetime Intake	0.3	0.4	0.5	0.7	0.7	0.7	0.7	0.0	0.2	-0.6
Incentive Sensitization - Responses	1.1	1.1	1.7	1.0	1.0	1.1	1.0	1.3	1.2	-0.9
Incentive Sensitization - Breakpoint	1.6	1.6	2.3	1.1	1.1	1.3	1.1	1.5	1.4	-1.1
Progressive ratio test 1 active lever presses	0.5	0.5	2.2	0.0	0.0	-0.1	0.0	-1.5	-1.1	0.0
Progressive ratio test 1 breakpoint	0.6	0.6	2.4	0.2	0.2	0.1	0.2	-1.6	-1.2	-0.1
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.2	1.0	1.0	1.1	1.0	0.3	0.3	-1.1
Progressive ratio test 2 active lever presses	0.5	0.5	0.7	0.8	0.8	0.8	0.8	-0.4	-0.2	-0.8
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	0.8	0.8	1.0	0.8	-0.0	0.1	-0.8
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.0	1.0	1.0	1.0	1.0	0.5	0.7	-1.0
Total sessions with >9 infusions	0.1	0.1	0.2	0.4	0.4	0.4	0.4	-0.2	-0.1	-0.4
Short access day 1 total inactive lever presses	0.6	0.7	0.9	0.9	0.9	0.9	0.9	0.5	0.5	-0.9
Short access day 10 total inactive lever presses	0.4	0.4	0.5	0.7	0.7	0.7	0.7	-0.6	-0.2	-0.7
Short access day 1 total infusions	0.2	0.2	0.5	-0.3	-0.3	-0.3	-0.3	-0.6	-0.7	0.4
Short access day 10 total infusions	0.1	0.1	0.3	0.3	0.3	0.2	0.3	0.5	0.6	-0.1
Short access total infusions	0.2	0.2	0.3	0.5	0.5	0.5	0.5	0.4	0.5	-0.5
Short access day 1 locomotion	0.1	0.1	0.1	-0.2	-0.2	-0.2	-0.2	-0.1	0.3	0.3
Short access day 10 total locomotion	1.2	1.3	2.4	1.1	1.1	1.0	1.1	1.0	1.5	-1.1
Short access total locomotion	1.3	1.3	2.1	1.1	1.1	1.0	1.1	1.1	1.5	-1.1
Compulsive drug intake	0.1	0.1	0.1	-0.2	-0.2	-0.3	-0.2	0.0	0.4	0.0
One hour access (0.3 mA shock)	0.3	0.3	0.4	0.6	0.6	0.6	0.6	0.1	0.5	-0.6
One hour access (shock baseline)	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.4	-0.3	0.1
Number of responses in last shaping day	0.2	0.2	0.6	-0.2	-0.2	-0.2	-0.2	0.7	0.8	0.2
Context. condit. distance diff. score	1.3	1.5	2.3	1.1	1.1	1.1	1.1	-1.4	-1.5	-1.1
Locomotion velocity, session 1	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.3	0.1	0.5
Locomotion distance, session 1	0.5	0.6	2.3	0.1	0.1	0.1	0.1	1.5	1.3	0.1
Locomotion velocity, session 2	0.3	0.3	0.8	-0.4	-0.4	-0.4	-0.4	0.9	0.6	0.5
Locomotion distance, session 2	0.5	0.7	2.7	0.0	0.0	0.0	0.0	1.7	1.5	0.1
Locomotion velocity, session 3	0.9	1.0	1.9	-0.8	-0.8	-0.8	-0.8	-1.3	-1.4	1.0
Locomotion distance, session 3	0.3	0.3	1.3	-0.1	-0.1	-0.1	-0.1	-1.1	-0.8	0.1
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	-1.1	-1.1	-1.1	-1.1	-0.1	-0.5	1.1
Stereotopy head waving duration, day 3	1.8	2.1	2.9	-1.7	-1.7	-1.7	-1.7	-0.2	-0.7	1.7
Locomotion velocity, session 7	3.7	4.1	5.6	2.4	2.4	2.4	2.4	-0.7	-0.7	-2.2
Locomotion distance, session 7	4.2	5.4	7.7	2.8	2.8	2.8	2.8	-0.1	0.1	-2.6
Stereotopy head waving bouts, day 7	1.2	1.4	1.9	-1.4	-1.4	-1.4	-1.4	-0.4	-0.4	1.4
Stereotopy head waving duration, day 7	2.5	3.0	3.9	-2.0	-2.0	-2.0	-2.0	-0.9	-1.0	2.0
Locomotion velocity, session 8	0.4	0.5	1.3	-0.5	-0.5	-0.5	-0.5	-0.9	-1.1	0.5
Locomotion distance, session 8	0.4	0.6	0.9	1.0	1.0	1.0	1.0	0.3	0.0	-0.9
Degree of sensitization distance	6.0	6.1	8.1	2.8	2.8	2.8	2.8	1.2	1.0	-2.8
Degree of sensitization stereotypy	0.9	1.0	1.4	-1.2	-1.2	-1.2	-1.2	-0.6	-0.4	1.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.6	-0.6	-0.6	-0.6	0.3	0.5	0.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.2	-1.5	-1.5	-1.5	-1.5	-1.3	-1.1	1.4
Condit. Reinf. active responses	0.6	0.7	2.5	0.2	0.2	0.2	0.2	1.4	1.6	-0.3
Condit. Reinf. inactive responses	4.7	5.5	10.2	1.9	1.9	1.9	1.9	3.2	3.1	-1.9
Incentive salience index mean	0.5	0.6	0.9	-0.8	-0.8	-0.8	-0.8	0.7	1.0	0.6
Condit. Reinf. lever presses	0.6	0.7	2.5	-0.4	-0.4	-0.4	-0.4	1.4	1.6	0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.3	0.3	0.3	0.3	-0.4	-0.1	-0.3
Time in novel zone, hab. session 1	1.8	1.7	1.9	-1.3	-1.3	-1.3	-1.3	-1.2	-1.4	1.3
Total zone transitions, hab. session 1	0.1	0.1	0.4	-0.1	-0.1	-0.1	-0.1	0.7	0.6	0.3
Total locomotion distance, hab. session 1	0.4	0.5	1.8	0.3	0.3	0.3	0.3	1.3	1.3	-0.3
Locomotion velocity, hab. session 1	1.0	1.5	4.3	0.6	0.6	0.6	0.6	2.0	2.1	-0.6
Time in familiar zone, hab. session 2	2.0	2.1	5.9	-1.0	-1.0	-1.0	-1.0	-2.4	-2.0	0.8
Time in novel zone, hab. session 2	0.8	0.8	2.9	0.5	0.5	0.5	0.5	1.7	1.3	-0.4
Total zone transitions, hab. session 2	1.0	1.3	2.3	-1.3	-1.3	-1.3	-1.3	0.2	0.1	1.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	0.3	0.3	0.7
Locomotion velocity, hab. session 2	0.4	0.6	1.0	-0.8	-0.8	-0.8	-0.8	0.3	0.3	1.0
Novel to familiar place preference ratio	0.6	0.6	2.1	0.5	0.5	0.5	0.5	1.5	1.1	-0.5
Novelty place preference	0.5	0.5	1.8	0.4	0.4	0.4	0.4	1.3	1.1	-0.4
Time in novel zone, NPP test	0.3	0.3	1.3	0.1	0.1	0.1	0.1	1.1	0.9	-0.1
Total zone transitions, NPP test	0.5	0.7	1.8	0.6	0.6	0.6	0.6	1.3	1.3	-0.4
Total locomotion distance, NPP test	3.3	4.6	6.9	2.0	2.0	2.0	2.0	2.5	2.6	-1.9
Locomotion velocity, NPP test	3.1	4.5	6.3	2.0	2.0	2.0	2.0	2.4	2.5	-1.9
Pavlov. Cond. lever latency	0.3	0.4	1.5	-0.2	-0.2	-0.2	-0.2	-0.9	-1.2	0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.7	0.7	0.7	0.7	0.5	0.8	-0.7
Pavlov. Cond. change in total contacts	0.8	0.8	1.0	-1.0	-1.0	-1.0	-1.0	0.5	0.7	0.9
Pavlov. Cond. index score	0.1	0.2	0.9	0.1	0.1	0.1	0.1	0.5	0.9	-0.1
Pavlov. Cond. latency score	0.2	0.3	1.3	0.2	0.2	0.2	0.2	0.7	1.1	-0.2
Pavlov. Cond. lever contacts	0.3	0.4	1.5	0.2	0.2	0.2	0.2	0.9	1.2	-0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.1	-0.4	-0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.5	0.4	0.4	0.4	0.4	1.6	1.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.6	-0.1	-0.1	-0.1	-0.1	0.4	0.8	0.1
Pavlov. Cond. response bias	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.2	0.4	0.1
Bone: apparent density	1.4	2.4	2.7	1.6	1.6	1.6	1.6	1.5	1.3	-1.7
Bone surface	0.9	1.6	2.4	1.1	1.1	1.1	1.1	1.5	1.5	-1.2
Bone volume	1.0	1.7	2.7	1.1	1.1	1.1	1.1	1.6	1.6	-1.2
Bone: connectivity density	2.0	3.1	4.0	1.9	1.9	1.9	1.9	1.3	1.2	-2.0
Bone: cortical apparent density	0.3	0.4	1.4	0.4	0.4	0.4	0.4	-0.9	-1.2	-0.2
Bone: cortical area	0.2	0.3	0.8	0.4	0.4	0.4	0.4	0.8	0.9	-0.4
Bone: cortical porosity	1.0	1.1	1.6	-1.3	-1.3	-1.3	-1.3	0.1	0.2	1.2
Bone: cortical porosity	0.6	0.7	0.8	-0.9	-0.9	-0.9	-0.9	0.6	0.6	0.8
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.2	0.2	0.2	0.5	0.4	-0.2
Bone: cortical thickness	0.1	0.1	0.5	0.2	0.2	0.2	0.2	-0.4	-0.7	-0.1
Bone: cortical tissue density	0.4	0.5	1.7	0.3	0.3	0.3	0.3	-1.0	-1.3	-0.1
Bone: elastic displacement	0.6	0.7	2.4	0.2	0.2	0.2	0.2	1.5	1.4	-0.3
Bone: elastic work	1.3	1.7	6.1	0.4	0.4	0.4	0.4	2.5	2.3	-0.4
Bone: endosteal estimation	0.1	0.1	0.5	0.3	0.3	0.3	0.3	0.3	0.7	-0.3
Bone: endosteal perimeter	0.2	0.4	1.6	0.2	0.2	0.2	0.2	0.8	1.3	-0.3
Bone: final force	0.0	0.1	0.2	-0.0	-0.0	-0.0	-0.0	0.3	0.5	-0.2
Bone: final moment	0.2	0.3	0.9	0.1	0.1	0.1	0.1	0.8	1.0	-0.3
Bone: marrow area	0.1	0.3	0.7	0.4	0.4	0.4	0.4	0.4	0.8	-0.5
Bone: maximum diameter	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.4	-0.4	-0.1	0.3
Bone: maximum force	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.3	0.5	0.6	0.2
Bone: maximum moment	0.2	0.4	1.4	-0.0	-0.0	-0.0	-0.0	1.1	1.2	-0.1
Bone: minimum diameter	0.2	0.4	1.7	0.1	0.1	0.1	0.1	1.1	1.3	-0.1
Bone: periosteal estimation	0.2	0.4	0.9	0.5	0.5	0.5	0.5	0.6	1.0	-0.5
Bone: periosteal perimeter	0.2	0.4	1.1	0.4	0.4	0.4	0.4	0.7	1.0	-0.4
Bone: post-yield work	0.3	0.3	0.6	0.5	0.5	0.5	0.5	-0.8	-0.7	-0.6
Bone: stiffness	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	-0.7	-0.5	0.4
Bone: tissue strength	0.4	0.3	1.0	0.4	0.4	0.4	0.4	0.7	1.0	-0.6
Bone: trabecular number	2.1	3.3	3.8	1.9	1.9	1.9	1.9	1.8	1.5	-1.9
Bone: trabecular spacing	2.2	2.9	3.5	-1.8	-1.8	-1.8	-1.8	-1.3	-1.2	1.9
Bone: trabecular thickness	1.3	1.5	2.5	1.2	1.2	1.2	1.2	1.6	1.2	-1.1
Bone: trabecular tissue density	1.0	1.4	2.0	-1.4	-1.4	-1.4	-1.4	-0.6	-0.7	1.4
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.1	-0.5	0.3
Distance traveled before self-admin	1.2	1.3	2.2	-1.3	-1.3	-1.2	-1.3	-0.3	-0.4	1.5
Distance traveled after self-admin	1.6	1.7	2.1	-1.4	-1.4	-1.4	-1.4	-0.8	-1.1	1.4
Delta time in closed arm before/after self-admin	0.6	0.6	0.7	0.8	0.8	0.6	0.8	0.6	0.7	-0.8
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.3	0.3	0.3	0.3	-0.4	-0.2	-0.4
Diff in mean of infusions in LGA sessions	0.7	0.8	1.4	-1.0	-1.0	-0.9	-1.0	0.2	-0.5	1.2
Extinction: sum of active levers before priming	3.0	3.0	3.5	1.9	1.9	1.8	1.9	1.6	1.2	-1.8
Active lever presses in extinction session 6	0.5	0.5	0.8	0.8	0.8	0.8	0.8	0.2	0.1	-0.9
Delta distance traveled before/after self-admin	1.5	1.6	2.4	-1.2	-1.2	-1.2	-1.2	-1.6	-1.6	1.0
Delta ambulatory time before/after self-admin	1.3	1.4	1.7	-1.1	-1.1	-1.2	-1.1	-1.3	-1.3	1.0
Time in closed arm before self-admin	1.0	1.1	1.5	-1.1	-1.1	-0.9	-1.1	-0.8	-1.2	1.2
Time in closed arm after self-admin	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.2	-0.2	0.7
Time in open arm before self-admin	0.0	0.0	0.1	0.1	0.1	0.0	0.1	0.1	0.4	0.0
Time in open arm after self-admin	0.2	0.2	0.4	0.5	0.5	0.6	0.5	-0.5	0.0	-0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.6	0.6	0.4	0.6	-0.1	-0.7	-0.5
Time to tail flick, vehicle, before self-admin	1.2	1.3	1.6	1.1	1.1	1.2	1.1	1.2	1.2	-0.8
Time to tail flick, vehicle, after self-admin	4.8	5.1	6.7	-2.1	-2.1	-2.0	-2.1	-2.6	-2.6	2.2
Time to tail flick, test, before self-admin	1.3	1.2	2.4	0.9	0.9	0.9	0.9	1.4	1.6	-1.2
Time to tail flick, test, after self-admin	3.8	3.9	5.5	2.3	2.3	2.4	2.3	0.4	0.5	-2.3
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	4.5	-1.2	-1.2	-1.2	-1.2	-2.1	-2.0	1.1
Delta time to tail flick, test, before/after SA	1.3	1.2	2.2	1.0	1.0	1.0	1.0	-1.5	-1.3	-0.8
Ambulatory time before self-admin	0.3	0.3	0.5	-0.6	-0.6	-0.7	-0.6	0.2	0.2	0.7
Ambulatory time after self-admin	2.4	2.7	3.3	-1.8	-1.8	-1.8	-1.8	-1.0	-1.1	1.8
Total heroin consumption	0.7	0.9	1.4	-1.0	-1.0	-1.0	-1.0	0.3	-0.6	1.2
Area under the delay curve	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	0.2	0.3	0.0
Delay disc. indifference point, 0s delay	0.9	1.0	2.5	0.6	0.6	0.6	0.6	1.6	1.6	-0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.0	-0.1	-0.2
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	-0.8	-0.8	-0.8	-0.8	0.1	0.7	0.7
Delay disc. indifference point, 24s delay	0.3	0.2	0.5	-0.4	-0.4	-0.4	-0.4	-0.1	-0.7	0.7
Delay disc. indifference point, 4s delay	0.9	0.9	1.1	-1.1	-1.1	-1.1	-1.1	-1.0	-0.6	1.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	0.4	0.4	0.4	0.3	0.4	-0.4
Delay discount exponential model param	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.1	-0.1	-0.3
Delay discount hyperbolic model param	0.2	0.2	0.4	0.6	0.6	0.6	0.6	0.1	-0.1	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.3	0.7	0.1	0.1
Change in fecal boli incidents, locomotor task	1.1	1.0	1.7	-0.9	-0.9	-0.9	-0.9	-1.2	-1.3	0.8
Time >=10cm from walls, locomotor time 1	1.4	1.5	2.2	1.1	1.1	1.1	1.1	1.2	1.5	-1.3
Bouts of movement, locomotor time 1	3.5	3.9	4.2	-2.0	-2.0	-2.0	-2.0	-2.0	-2.0	2.0
Total resting periods, locomotor time 1	4.2	4.6	6.4	-2.0	-2.0	-2.0	-2.0	-2.5	-2.5	2.0
Rest time, locomotor task time 1	3.1	3.4	5.9	-1.6	-1.6	-1.6	-1.6	-2.4	-2.4	1.6
Distance moved, locomotor task time 1	1.6	1.8	2.4	1.3	1.3	1.3	1.3	1.4	1.5	-1.1
Vertical activity count, locomotor time 1	0.6	0.7	2.3	-0.2	-0.2	-0.2	-0.2	1.5	1.4	0.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.3	-0.3	0.6
Bouts of movement, locomotor time 2	3.4	3.6	5.7	-1.8	-1.8	-1.8	-1.8	-1.9	-2.4	1.9
Total resting periods, locomotor time 2	4.3	4.6	8.0	-1.9	-1.9	-1.9	-1.9	-2.3	-2.8	2.0
Rest time, locomotor task time 2	2.0	2.4	6.3	-1.1	-1.1	-1.1	-1.1	-2.1	-2.5	1.1
Distance moved, locomotor task time 2	2.5	2.9	5.9	1.5	1.5	1.5	1.5	2.0	2.4	-1.4
Vertical activity count, locomotor time 2	0.8	0.9	3.6	-0.1	-0.1	-0.1	-0.1	1.9	1.7	0.3
Weight adjusted by age	0.9	1.0	1.3	-1.2	-1.2	-1.1	-1.2	-0.4	0.1	1.1
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	3.8	0.9	0.9	1.0	0.9	1.9	2.0	-1.0
Locomotion in novel chamber	0.1	0.1	0.3	0.2	0.2	0.2	0.2	-0.1	0.5	-0.5
Locomotion in novel chamber post-restriction	0.7	0.8	1.1	-1.1	-1.1	-1.0	-1.1	-0.4	-0.7	0.8
Progressive ratio	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	-0.0	-0.0	0.5
Food seeking constrained by brief footshock	2.7	3.3	9.2	-1.3	-1.3	-1.2	-1.3	-2.3	-3.0	1.4
Seeking ratio, punishment vs. effort	0.5	0.6	2.2	-0.4	-0.4	-0.4	-0.4	-1.3	-1.5	0.4
Run reversals in cocaine runway, females	2.7	2.7	3.2	1.8	1.8	1.6	1.8	1.7	1.2	-1.5
Run reversals in cocaine runway, males	3.3	3.2	4.8	-1.9	-1.9	-2.2	-1.9	-1.3	-1.0	1.9
Latency to leave start box in cocaine runway	2.1	2.3	3.0	-1.6	-1.6	-1.7	-1.6	-1.4	-1.2	1.4
Latency to leave start box in cocaine runway, F	3.2	3.6	4.2	-2.1	-2.1	-1.9	-2.1	-1.6	-1.5	1.9
Latency to leave start box in cocaine runway, M	0.4	0.4	0.5	0.6	0.6	0.2	0.6	0.6	0.7	-0.7
Cd content in liver	0.3	0.3	0.8	0.4	0.4	0.4	0.4	0.9	0.7	-0.4
Co content in liver	3.3	3.9	5.3	-1.9	-1.9	-1.9	-1.9	-2.2	-2.3	1.9
Cu content in liver	1.0	1.2	1.6	-1.1	-1.1	-1.1	-1.1	-0.8	-1.2	1.1
Fe content in liver	1.8	2.2	2.8	1.7	1.7	1.7	1.7	0.9	0.9	-1.5
K content in liver	0.3	0.3	0.4	0.6	0.6	0.6	0.6	0.2	0.1	-0.7
Mg content in liver	0.6	0.6	0.8	0.9	0.9	0.9	0.9	0.4	0.4	-0.9
Mn content in liver	2.2	2.5	2.9	1.6	1.6	1.6	1.6	1.6	1.5	-1.7
Na content in liver	1.3	1.4	2.0	-1.1	-1.1	-1.1	-1.1	1.4	1.3	1.0
Rb content in liver	0.2	0.3	0.4	0.6	0.6	0.6	0.6	-0.3	-0.2	-0.6
Se content in liver	1.5	1.8	6.5	0.4	0.4	0.4	0.4	2.5	2.2	-0.5
Sr content in liver	0.3	0.3	0.3	0.5	0.5	0.5	0.5	0.6	0.5	-0.5
Zn content in liver	0.8	0.9	1.1	-1.0	-1.0	-1.0	-1.0	0.8	0.6	1.0