Hub : Traits

Run reversals in cocaine runway, males

Number of run direction reversals in cocaine runway task, male

Tags: Behavior · Cocaine

Project: u01_tom_jhou

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 7.1e-10 NaN NA NA NA
2 10 62271668 63667097 1 1 9.4e-12 0.345 1.00 100 Eral1
3 13 83800106 85188650 1 1 1.7e-10 0.067 0.21 52 Vangl2

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.2 1 0 0 0 1 Vangl2
BMI without tail 171.8 1 1 33 0 1 NA
Body weight 11.2 1 1 33 0 1 NA
Epididymis fat weight 136.2 1 1 33 0 1 NA
Glucose 6.6 1 0 0 0 1 NA
Heart weight 11.4 1 0 0 0 1 NA
Left kidney weight 62.7 1 1 33 0 1 NA
Right kidney weight 67.3 1 1 33 0 1 NA
Tail length 91.1 1 1 33 0 1 NA
Length with tail 4.0 1 0 0 0 1 NA
Length without tail 120.2 1 1 33 0 1 NA
Liver weight, left 23.6 1 1 33 0 1 NA
Liver weight, right 9.6 1 0 0 0 1 NA
Parametrial fat weight 26.4 1 1 33 0 1 NA
Retroperitoneal fat weight 3.1 2 0 0 0 1 Vangl2 NA
Intraocular pressure 29.4 1 1 33 0 1 NA
Extensor digitorum longus weight 39.2 1 1 33 0 1 NA
Soleus weight 21.9 1 1 33 0 1 NA
Tibialis anterior weight 96.0 1 1 33 0 1 NA
Tibia length 7.4 1 0 0 0 1 NA
Number of licking bursts 242.4 1 1 33 0 1 NA
Food consumed during 24 hour testing period 16.1 2 0 0 0 1 Eral1 NA
Times rat made contact with spout 70.6 2 1 33 0 1 Eral1 NA
Mean time between licks in bursts 48.0 2 1 33 0 1 Eral1 NA
Mean num. licks in bursts 137.4 2 1 33 0 1 Eral1 NA
Std. dev. time between licks in bursts 152.4 2 1 33 0 1 Eral1 NA
Water consumed over 24 hours 5.7 1 0 0 0 1 NA
Indifference point 0 sec 21.3 1 1 33 0 1 NA
Indifference point AUC 66.7 1 1 33 0 1 NA
Indifference point function ln k 4.4 1 0 0 0 1 NA
Indifference point function log k 4.4 1 0 0 0 1 NA
Delay discounting total patch changes 0 sec 20.1 1 1 33 0 1 NA
Delay discounting total patch changes 12 sec 156.9 1 1 33 0 1 NA
Delay discounting total patch changes 18 sec 277.7 1 1 33 0 1 NA
Delay discounting total patch changes 24 sec 43.7 1 1 33 0 1 NA
Delay discounting total patch changes 6 sec 145.0 1 1 33 0 1 NA
Delay discounting water rate 0 sec 11.8 1 0 0 0 1 NA
Delay discounting water rate 12 sec 44.2 1 1 33 0 1 NA
Delay discounting water rate 18 sec 10.5 1 0 0 0 1 NA
Delay discounting water rate 24 sec 100.9 1 1 33 0 1 NA
Delay discounting water rate 6 sec 70.2 1 1 33 0 1 NA
Locomotor activity 4.0 1 0 0 0 1 Vangl2
Locomotor testing distance 14.0 1 0 0 0 1 NA
Locomotor testing rearing 23.9 1 1 33 0 1 NA
Light reinforcement 1 84.1 1 1 33 0 1 NA
Reaction time number correct 7.7 2 0 0 0 1 Vangl2 NA
Reaction time mean minus median AUC 8.2 1 0 0 0 1 Vangl2
Reaction time num false alarms 47.4 2 1 33 0 1 Vangl2 NA
Reaction time num false alarms AUC 128.2 1 1 33 0 1 NA
Reaction time trials correct on left 7.7 2 0 0 0 1 Vangl2 NA
Reaction time trials on left 8.2 2 0 0 0 1 Vangl2 NA
Reaction time mean 62.5 1 1 33 0 1 NA
Reaction time mean AUC 47.1 2 1 33 0 1 Vangl2 NA
Median of all reaction times 80.2 1 1 33 0 1 NA
Reaction time false alarm rate 56.6 2 1 33 0 1 Vangl2 NA
Reaction time premature initiation rate 47.3 1 1 33 0 1 NA
Reaction time premature initiations 49.8 1 1 33 0 1 NA
Std. dev. reaction times 27.0 1 1 33 0 1 NA
Reaction time trials completed 8.2 2 0 0 0 1 Vangl2 NA
Reaction time trials AUC 11.2 2 0 0 0 1 Vangl2 NA
Social responses 108.6 1 1 33 0 1 NA
Social time 6.5 2 0 0 0 1 Vangl2 NA
Cocaine response after cond. corrected 135.7 1 1 33 0 1 NA
Cocaine response after cond. not corrected 176.6 1 1 33 0 1 NA
Cocaine response before conditioning 28.6 1 1 33 0 1 NA
Saline control response 50.6 1 1 33 0 1 NA
Condit. Reinf. active minus inactive responses 46.4 1 1 33 0 1 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 33 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Pavlov. Cond. lever latency 60.5 1 1 33 0 1 NA
Pavlov. Cond. magazine entry latency 173.4 1 1 33 0 1 NA
Pavlov. Cond. change in total contacts 216.7 1 1 33 0 1 NA
Pavlov. Cond. index score 102.2 1 1 33 0 1 NA
Pavlov. Cond. latency score 110.3 1 1 33 0 1 NA
Pavlov. Cond. lever contacts 29.4 1 1 33 0 1 NA
Pavlov. Cond. magazine entry number 244.9 1 1 33 0 1 NA
Pavlov. Cond. intertrial magazine entries 106.2 1 1 33 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 90.6 1 1 33 0 1 NA
Pavlov. Cond. response bias 51.3 1 1 33 0 1 NA
Conditioned reinforcement - actives 18.5 1 0 0 0 1 NA
Conditioned locomotion 9.9 1 0 0 0 1 NA
Intermittent access intake day 1-15 change 104.0 1 1 33 0 1 NA
Intermittent access intake escalation 141.1 1 1 33 0 1 NA
Intermittent access intake escalation 2 19.4 3 1 33 0 1 Vangl2 Eral1 NA
Intermitt. access day 1 inactive lever presses 18.2 2 1 33 0 1 Eral1 NA
Intermitt. access day 15 inactive lever presses 19.8 1 0 0 0 1 Eral1
Intermitt. access escalation Index 9.2 1 0 0 0 1 NA
Intermittent access day 1 total infusions 52.9 1 1 33 0 1 NA
Intermittent access day 1 locomotion 27.1 1 1 33 0 1 NA
Intermittent access total locomotion 7.3 1 0 0 0 1 Eral1
Post-drug Anxiety 20.6 1 0 0 0 1 NA
Baseline Anxiety 8.1 1 0 0 0 1 Vangl2
Progressive ratio test 1 active lever presses 11.8 1 0 0 0 1 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0 1 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0 1 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0 1 NA
Progressive ratio test 2 breakpoint 61.6 1 1 33 0 1 NA
Total sessions with >9 infusions 11.1 1 0 0 0 1 Vangl2
Short access day 1 total inactive lever presses 6.0 1 0 0 0 1 Vangl2
Short access day 10 total inactive lever presses 12.2 1 0 0 0 1 NA
Short access day 1 total infusions 28.5 1 1 33 0 1 Eral1
Short access day 10 total infusions 24.0 1 1 33 0 1 NA
Short access total infusions 17.6 1 0 0 0 1 Eral1
Short access day 1 locomotion 20.2 2 0 0 0 1 Eral1 NA
Short access total locomotion 23.8 1 0 0 0 1 Eral1
Compulsive drug intake 45.4 1 1 33 0 1 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0 1 NA
Context. condit. distance diff. score 240.2 1 1 33 0 1 NA
Locomotion velocity, session 1 190.8 1 1 33 0 1 NA
Locomotion distance, session 1 609.6 1 1 33 0 1 NA
Locomotion velocity, session 2 139.6 1 1 33 0 1 NA
Locomotion distance, session 2 1269.9 1 1 33 0 1 NA
Locomotion velocity, session 3 178.9 1 1 33 0 1 NA
Locomotion distance, session 3 117.5 1 1 33 0 1 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0 1 NA
Stereotopy head waving duration, day 3 33.2 1 1 33 0 1 NA
Locomotion velocity, session 7 52.4 2 1 33 0 1 Vangl2 NA
Locomotion distance, session 7 18.3 2 1 33 0 1 Vangl2 NA
Stereotopy head waving bouts, day 7 68.4 1 1 33 0 1 NA
Stereotopy head waving duration, day 7 102.2 1 1 33 0 1 NA
Locomotion distance, session 8 171.7 1 1 33 0 1 NA
Degree of sensitization distance 103.6 2 1 33 0 1 Vangl2 NA
Degree of sensitization stereotypy 37.5 1 1 33 0 1 NA
Condit. Reinf. active minus inactive responses 5.6 1 0 0 0 1 NA
Condit. Reinf. active-inactive response ratio 107.3 1 1 33 0 1 NA
Condit. Reinf. active responses 20.0 1 0 0 0 1 NA
Condit. Reinf. inactive responses 11.3 2 0 0 0 1 Vangl2 NA
Incentive salience index mean 15.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 35.1 1 1 33 0 1 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0 1 NA
Time in novel zone, hab. session 1 11.7 2 0 0 0 1 Vangl2 NA
Total zone transitions, hab. session 1 673.8 1 1 33 0 1 NA
Total locomotion distance, hab. session 1 279.4 1 1 33 0 1 NA
Locomotion velocity, hab. session 1 349.5 1 1 33 0 1 NA
Time in familiar zone, hab. session 2 48.9 1 1 33 0 1 NA
Time in novel zone, hab. session 2 58.4 1 1 33 0 1 NA
Total zone transitions, hab. session 2 212.9 2 1 33 0 1 Vangl2 NA
Total locomotion distance, hab. session 2 214.3 1 1 33 0 1 NA
Locomotion velocity, hab. session 2 225.0 1 1 33 0 1 NA
Total zone transitions, NPP test 190.2 2 1 33 0 1 Vangl2 NA
Total locomotion distance, NPP test 269.3 1 1 33 0 1 NA
Locomotion velocity, NPP test 317.8 1 1 33 0 1 NA
Pavlov. Cond. lever latency 9.3 1 0 0 0 1 NA
Pavlov. Cond. magazine entry latency 95.9 1 1 33 0 1 NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0 1 NA
Pavlov. Cond. index score 51.9 1 1 33 0 1 NA
Pavlov. Cond. latency score 16.6 1 0 0 0 1 NA
Pavlov. Cond. lever contacts 16.1 1 0 0 0 1 NA
Pavlov. Cond. magazine entry number 61.6 1 1 33 0 1 NA
Pavlov. Cond. lever-magazine prob. diff. 88.1 1 1 33 0 1 NA
Pavlov. Cond. response bias 52.4 1 1 33 0 1 NA
Bone: apparent density 31.2 1 1 33 0 1 NA
Bone surface 41.3 1 1 33 0 1 NA
Bone volume 47.7 1 1 33 0 1 NA
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical porosity 188.5 1 1 33 0 1 NA
Bone: cortical porosity 155.8 1 1 33 0 1 NA
Bone: cortical thickness 8.8 1 0 0 0 1 NA
Bone: cortical thickness 17.9 1 0 0 0 1 NA
Bone: elastic displacement 28.2 1 1 33 0 1 NA
Bone: endosteal estimation 18.4 1 1 33 0 1 NA
Bone: final force 57.4 1 1 33 0 1 NA
Bone: final moment 45.6 1 1 33 0 1 NA
Bone: marrow area 15.3 1 1 33 0 1 NA
Bone: maximum force 60.3 1 1 33 0 1 NA
Bone: maximum moment 41.2 1 1 33 0 1 NA
Bone: minimum diameter 86.7 1 1 33 0 1 NA
Bone: periosteal estimation 10.0 1 0 0 0 1 NA
Bone: periosteal perimeter 8.8 1 0 0 0 1 NA
Bone: post-yield work 124.3 1 1 33 0 1 NA
Bone: stiffness 136.8 1 1 33 0 1 NA
Bone: tissue strength 136.0 1 1 33 0 1 NA
Bone: trabecular number 64.1 1 1 33 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 13.8 1 0 0 0 1 NA
Bone: trabecular tissue density 66.6 1 1 33 0 1 NA
Breakpoint value in progressive ratio session 7.3 1 0 0 0 1 Eral1
Distance traveled before self-admin 35.5 2 1 33 0 1 Eral1 NA
Distance traveled after self-admin 7.5 1 0 0 0 1 Eral1
Delta time in open arm before/after self-admin 24.1 2 1 33 0 1 Eral1 NA
Extinction: sum of active levers before priming 10.2 2 0 0 0 1 Eral1 NA
Active lever presses in extinction session 6 14.7 2 0 0 0 1 Eral1 NA
Delta distance traveled before/after self-admin 9.9 2 0 0 0 1 Eral1 NA
Delta ambulatory time before/after self-admin 37.5 1 1 33 0 1 Eral1
Time in closed arm before self-admin 78.0 1 1 33 0 1 NA
Time in closed arm after self-admin 40.2 1 1 33 0 1 NA
Time in open arm after self-admin 20.9 2 1 33 0 1 Eral1 NA
Time to tail flick, vehicle, before self-admin 10.1 1 0 0 0 1 Eral1
Delta time to tail flick, vehicle, before/after SA 7.5 1 0 0 0 1 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0 1 NA
Ambulatory time before self-admin 23.9 3 1 33 0 1 Vangl2 Eral1 NA
Ambulatory time after self-admin 6.6 1 0 0 0 1 Eral1
Area under the delay curve 45.5 1 1 33 0 1 Eral1
Delay disc. indifference point, 16s delay 63.9 1 1 33 0 1 Eral1
Delay disc. indifference point, 24s delay 8.5 2 0 0 0 1 Vangl2 Eral1
Delay disc. indifference point, 4s delay 6.5 1 0 0 0 1 Eral1
Delay disc. indifference point, 8s delay 71.9 1 1 33 0 1 Eral1
Delay discount exponential model param 36.3 1 1 33 0 1 Eral1
Delay discount hyperbolic model param 29.7 1 1 33 0 1 Eral1
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0 1 NA
Rest time, locomotor task time 1 15.2 1 0 0 0 1 Eral1
Time >=10cm from walls, locomotor time 2 25.4 3 2 67 0 1 Vangl2 Eral1 NA
Total resting periods, locomotor time 2 6.0 1 0 0 0 1 NA
Rest time, locomotor task time 2 7.2 2 0 0 0 1 Eral1 NA
Distance moved, locomotor task time 2 13.3 2 0 0 0 1 Eral1 NA
Vertical activity count, locomotor time 2 8.7 1 0 0 0 1 Eral1
Weight adjusted by age 25.0 1 1 33 0 1 NA
Seeking ratio, delayed vs. immediate footshock 7.9 2 0 0 0 1 Vangl2 NA
Locomotion in novel chamber 10.2 1 0 0 0 1 NA
Locomotion in novel chamber post-restriction 16.1 2 0 0 0 1 Vangl2 Eral1
Progressive ratio 16.8 2 1 33 0 1 Vangl2 Eral1
Food seeking constrained by brief footshock 14.0 1 0 0 0 1 Eral1
Seeking ratio, punishment vs. effort 10.2 1 0 0 0 1 Eral1
Run reversals in cocaine runway, females 8.1 1 0 0 0 1 Vangl2
Latency to leave start box in cocaine runway 15.7 2 0 0 0 1 Eral1 NA
Latency to leave start box in cocaine runway, M 38.5 1 1 33 0 1 Eral1
Cd content in liver 239.3 1 1 33 0 1 NA
Co content in liver 143.3 1 1 33 0 1 NA
Fe content in liver 10.3 1 0 0 0 1 NA
K content in liver 87.3 1 1 33 0 1 NA
Mn content in liver 207.1 1 1 33 0 1 NA
Rb content in liver 31.4 1 1 33 0 1 NA
Se content in liver 47.0 1 1 33 0 1 NA
Zn content in liver 46.0 1 1 33 0 1 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.00
Adipose alternative TSS 0 0.000 0.93
Adipose gene expression 1 0.012 0.99
Adipose isoform ratio 0 0.000 0.95
Adipose intron excision ratio 0 0.000 0.99
Adipose mRNA stability 0 0.000 0.97
BLA alternative polyA 0 0.000 0.95
BLA alternative TSS 0 0.000 0.87
BLA gene expression 0 0.000 0.96
BLA isoform ratio 0 0.000 0.93
BLA intron excision ratio 0 0.000 0.93
BLA mRNA stability 0 0.000 0.95
Brain alternative polyA 0 0.000 0.96
Brain alternative TSS 0 0.000 0.99
Brain gene expression 0 0.000 0.97
Brain isoform ratio 0 0.000 0.98
Brain intron excision ratio 0 0.000 1.00
Brain mRNA stability 0 0.000 0.97
Eye alternative polyA 0 0.000 0.87
Eye alternative TSS 0 0.000 0.84
Eye gene expression 0 0.000 0.98
Eye isoform ratio 0 0.000 0.89
Eye intron excision ratio 0 0.000 0.91
Eye mRNA stability 0 0.000 0.74
IL alternative polyA 0 0.000 1.04
IL alternative TSS 0 0.000 0.82
IL gene expression 0 0.000 0.96
IL isoform ratio 0 0.000 1.08
IL intron excision ratio 0 0.000 0.98
IL mRNA stability 0 0.000 0.98
LHb alternative polyA 0 0.000 0.94
LHb alternative TSS 0 0.000 0.95
LHb gene expression 0 0.000 0.96
LHb isoform ratio 0 0.000 1.06
LHb intron excision ratio 0 0.000 1.00
LHb mRNA stability 0 0.000 0.96
Liver alternative polyA 0 0.000 0.91
Liver alternative TSS 0 0.000 0.98
Liver gene expression 0 0.000 0.96
Liver isoform ratio 0 0.000 0.95
Liver intron excision ratio 0 0.000 0.97
Liver mRNA stability 0 0.000 0.95
NAcc alternative polyA 0 0.000 0.94
NAcc alternative TSS 0 0.000 0.99
NAcc gene expression 0 0.000 0.97
NAcc isoform ratio 0 0.000 0.95
NAcc intron excision ratio 0 0.000 0.99
NAcc mRNA stability 0 0.000 0.94
OFC alternative polyA 0 0.000 0.96
OFC alternative TSS 0 0.000 0.82
OFC gene expression 0 0.000 0.99
OFC isoform ratio 0 0.000 1.00
OFC intron excision ratio 0 0.000 1.02
OFC mRNA stability 0 0.000 0.93
PL alternative polyA 0 0.000 0.96
PL alternative TSS 0 0.000 0.95
PL gene expression 0 0.000 0.97
PL isoform ratio 1 0.045 1.00
PL intron excision ratio 1 0.028 0.99
PL mRNA stability 0 0.000 0.97

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.