Degree of sensitization stereotypy

Degree of sensitization stereotypy, difference of head waving bouts during sessions 7 and 3

Tags: Behavior · Motivation

Project: p50_shelly_flagel_2014

1 locus · 1 gene with independent associations · 1 total associated gene

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr3 44152620 45549784 1 1 7.87e-11 4.07e-01 8.93e-24 Ly75

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 1.55 1 0 0 0 1e+00 Ly75
BMI without tail 3.94 1 0 0 0 1e+00 Ly75
Epididymis fat weight 3.44 1 0 0 0 1e+00 Ly75
Glucose 3.95 1 0 0 0 1e+00 Ly75
Length with tail 2.82 1 0 0 0 1e+00 Ly75
Length without tail 8.83 1 0 0 0 1e+00 Ly75
Liver weight, left 3.24 1 0 0 0 1e+00 Ly75
Parametrial fat weight 2.38 1 0 0 0 1e+00 Ly75
Retroperitoneal fat weight 8.85 1 1 100 0 1e+00 Ly75
Intraocular pressure 3.09 1 0 0 0 1e+00 Ly75
Extensor digitorum longus weight 1.63 1 0 0 0 1e+00 Ly75
Tibialis anterior weight 3.75 1 0 0 0 1e+00 Ly75
Number of licking bursts 7.94 1 0 0 0 1e+00 Ly75
Food consumed during 24 hour testing period 11.76 1 0 0 0 1e+00 Ly75
Times rat made contact with spout 3.58 1 0 0 0 1e+00 Ly75
Mean time between licks in bursts 2.99 1 0 0 0 1e+00 Ly75
Mean num. licks in bursts 4.84 1 0 0 0 1e+00 Ly75
Std. dev. time between licks in bursts 3.96 1 0 0 0 1e+00 Ly75
Water consumed over 24 hours 19.18 1 0 0 0 1e+00 Ly75
Patch foraging indifference point 0 sec 3.47 1 0 0 0 1e+00 Ly75
Patch foraging total patch changes 0 sec 2.94 1 0 0 0 1e+00 Ly75
Patch foraging total patch changes 18 sec 13.09 1 0 0 0 1e+00 Ly75
Locomotor activity 6.86 1 0 0 0 1e+00 Ly75
Locomotor testing distance 6.84 1 0 0 0 1e+00 Ly75
Locomotor testing rearing 4.53 1 0 0 0 1e+00 Ly75
Reaction time mean minus median 5.26 1 0 0 0 1e+00 Ly75
Reaction time mean minus median AUC 17.14 1 0 0 0 1e+00 Ly75
Reaction time num false alarms 2.93 1 0 0 0 1e+00 Ly75
Reaction time mean 9.87 1 0 0 0 1e+00 Ly75
Reaction time mean AUC 10.73 1 0 0 0 1e+00 Ly75
Median of all reaction times 5.14 1 0 0 0 1e+00 Ly75
Reaction time false alarm rate 4.06 1 0 0 0 1e+00 Ly75
Reaction time premature initiation rate 9.14 1 0 0 0 1e+00 Ly75
Reaction time premature initiations 4.53 1 0 0 0 1e+00 Ly75
Std. dev. reaction times 14.29 1 0 0 0 1e+00 Ly75
Cocaine response after cond. corrected 4.76 1 0 0 0 1e+00 Ly75
Cocaine response before conditioning 5.9 1 0 0 0 1e+00 Ly75
Saline control response 3.55 1 0 0 0 1e+00 Ly75
Condit. Reinf. active minus inactive responses 28.62 1 1 100 0 1e+00 Ly75
Condit. Reinf. active-inactive response ratio 11.56 1 0 0 0 1e+00 Ly75
Condit. Reinf. active responses 24.88 1 1 100 0 1e+00 Ly75
Condit. Reinf. inactive responses 3.32 1 0 0 0 1e+00 Ly75
Condit. Reinf. lever presses 8.53 1 0 0 0 1e+00 Ly75
Condit. Reinf. lever reinforcers received 19.5 1 1 100 0 1e+00 Ly75
Pavlov. Cond. change in total contacts 11.21 1 0 0 0 1e+00 Ly75
Locomotion velocity, session 1 6.3 1 0 0 0 1e+00 Ly75
Locomotion distance, session 3 14.48 1 0 0 0 1e+00 Ly75
Stereotopy head waving bouts, day 7 23.7 1 0 0 0 1e+00 Ly75
Stereotopy head waving duration, day 7 21.6 1 0 0 0 1e+00 Ly75
Degree of sensitization distance 10.32 1 0 0 0 1e+00 Ly75
Condit. Reinf. active minus inactive responses 16.76 1 0 0 0 1e+00 Ly75
Condit. Reinf. active-inactive response ratio 9.84 1 0 0 0 1e+00 Ly75
Condit. Reinf. active responses 13.63 1 0 0 0 1e+00 Ly75
Incentive salience index mean 15.42 1 0 0 0 1e+00 Ly75
Condit. Reinf. lever presses 3.87 1 0 0 0 1e+00 Ly75
Time in novel zone, hab. session 1 4.94 1 0 0 0 1e+00 Ly75
Total zone transitions, hab. session 1 7.48 1 0 0 0 1e+00 Ly75
Total zone transitions, hab. session 2 19.52 1 0 0 0 1e+00 Ly75
Total locomotion distance, hab. session 2 24.97 1 1 100 0 1e+00 Ly75
Locomotion velocity, hab. session 2 19.99 1 1 100 0 1e+00 Ly75
Total zone transitions, NPP test 5.39 1 0 0 0 1e+00 Ly75
Total locomotion distance, NPP test 4.87 1 0 0 0 1e+00 Ly75
Locomotion velocity, NPP test 4.37 1 0 0 0 1e+00 Ly75
Pavlov. Cond. index score 3.57 1 0 0 0 1e+00 Ly75
Pavlov. Cond. latency score 6.68 1 0 0 0 1e+00 Ly75
Pavlov. Cond. lever contacts 4.09 1 0 0 0 1e+00 Ly75
Bone: apparent density 27.67 1 1 100 0 1e+00 Ly75
Bone surface 47.59 1 1 100 0 1e+00 Ly75
Bone volume 43.15 1 1 100 0 1e+00 Ly75
Bone: connectivity density 21.24 1 1 100 0 1e+00 Ly75
Bone: cortical apparent density 18.66 1 0 0 0 1e+00 Ly75
Bone: cortical area 12.58 1 0 0 0 1e+00 Ly75
Bone: cortical thickness 5.93 1 0 0 0 1e+00 Ly75
Bone: cortical thickness 7.09 1 0 0 0 1e+00 Ly75
Bone: cortical tissue density 17.88 1 0 0 0 1e+00 Ly75
Bone: elastic work 15.82 1 0 0 0 1e+00 Ly75
Bone: endosteal estimation 9.05 1 0 0 0 1e+00 Ly75
Bone: final force 35.73 1 1 100 0 1e+00 Ly75
Bone: final moment 48.32 1 1 100 0 1e+00 Ly75
Bone: marrow area 9.02 1 0 0 0 1e+00 Ly75
Bone: maximum diameter 5.12 1 0 0 0 1e+00 Ly75
Bone: maximum force 20.87 1 1 100 0 1e+00 Ly75
Bone: maximum moment 29.34 1 1 100 0 1e+00 Ly75
Bone: minimum diameter 8.69 1 0 0 0 1e+00 Ly75
Bone: periosteal estimation 14.82 1 1 100 0 1e+00 Ly75
Bone: periosteal perimeter 7.52 1 0 0 0 1e+00 Ly75
Bone: stiffness 8.72 1 0 0 0 1e+00 Ly75
Bone: trabecular number 35.45 1 1 100 0 1e+00 Ly75
Bone: trabecular spacing 60.24 1 1 100 0 1e+00 Ly75
Bone: trabecular thickness 47.42 1 1 100 0 1e+00 Ly75
Diff in mean of infusions in LGA sessions 4.9 1 0 0 0 1e+00 Ly75
Delta time to tail flick, test, before/after SA 4.75 1 0 0 0 1e+00 Ly75
Total resting periods, locomotor time 1 5.85 1 0 0 0 1e+00 Ly75
Rest time, locomotor task time 1 12.3 1 0 0 0 1e+00 Ly75
Distance moved, locomotor task time 1 13.8 1 0 0 0 1e+00 Ly75
Rest time, locomotor task time 2 4.68 1 0 0 0 1e+00 Ly75
Distance moved, locomotor task time 2 4.29 1 0 0 0 1e+00 Ly75
Weight adjusted by age 20.87 1 0 0 0 1e+00 Ly75
Locomotion in novel chamber 34.01 1 1 100 0 1e+00 Ly75
Locomotion in novel chamber post-restriction 4.28 1 0 0 0 1e+00 Ly75
Food seeking constrained by brief footshock 13.79 1 0 0 0 1e+00 Ly75
Seeking ratio, punishment vs. effort 5.43 1 0 0 0 1e+00 Ly75
Run reversals in cocaine runway, females 21.72 1 0 0 0 1e+00 Ly75
Cd content in liver 5.1 1 0 0 0 1e+00 Ly75
Cu content in liver 8.78 1 0 0 0 1e+00 Ly75
Fe content in liver 7.43 1 0 0 0 1e+00 Ly75
K content in liver 12.92 1 0 0 0 1e+00 Ly75
Mg content in liver 13.79 1 0 0 0 1e+00 Ly75
Mn content in liver 32.26 1 1 100 0 1e+00 Ly75
Na content in liver 12.24 1 0 0 0 1e+00 Ly75
Rb content in liver 4.86 1 0 0 0 1e+00 Ly75
Sr content in liver 14.16 1 0 0 0 1e+00 Ly75
Zn content in liver 12.81 1 0 0 0 1e+00 Ly75

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.04
Adipose alternative TSS 0 0 1.16
Adipose gene expression 0 0 1.08
Adipose isoform ratio 0 0 1.09
Adipose intron excision ratio 0 0 1.11
Adipose mRNA stability 0 0 1.09
BLA alternative polyA 0 0 1.11
BLA alternative TSS 0 0 1.02
BLA gene expression 0 0 1.13
BLA isoform ratio 0 0 1.13
BLA intron excision ratio 0 0 1.09
BLA mRNA stability 0 0 1.09
Brain alternative polyA 0 0 1.1
Brain alternative TSS 0 0 1.04
Brain gene expression 0 0 1.09
Brain isoform ratio 0 0 1.04
Brain intron excision ratio 0 0 1.11
Brain mRNA stability 0 0 1.06
Eye alternative polyA 0 0 1.07
Eye alternative TSS 0 0 1.18
Eye gene expression 0 0 1.07
Eye isoform ratio 0 0 1.05
Eye intron excision ratio 0 0 1.03
Eye mRNA stability 0 0 1.06
IL alternative polyA 0 0 1.06
IL alternative TSS 0 0 1.22
IL gene expression 0 0 1.11
IL isoform ratio 0 0 1.11
IL intron excision ratio 0 0 1.08
IL mRNA stability 0 0 1.02
LHb alternative polyA 0 0 1.15
LHb alternative TSS 0 0 1.15
LHb gene expression 1 0 1.12
LHb isoform ratio 0 0 0.97
LHb intron excision ratio 0 0 1.11
LHb mRNA stability 0 0 1.07
Liver alternative polyA 0 0 1.05
Liver alternative TSS 0 0 1.1
Liver gene expression 0 0 1.09
Liver isoform ratio 0 0 1.06
Liver intron excision ratio 0 0 1.06
Liver mRNA stability 0 0 1.09
NAcc alternative polyA 0 0 1.08
NAcc alternative TSS 0 0 1.1
NAcc gene expression 0 0 1.13
NAcc isoform ratio 0 0 1.14
NAcc intron excision ratio 0 0 1.18
NAcc mRNA stability 0 0 1.06
OFC alternative polyA 0 0 1.12
OFC alternative TSS 0 0 1.14
OFC gene expression 0 0 1.12
OFC isoform ratio 0 0 1.14
OFC intron excision ratio 0 0 1.09
OFC mRNA stability 0 0 1.02
PL alternative polyA 0 0 1.1
PL alternative TSS 0 0 1.1
PL gene expression 0 0 1.11
PL isoform ratio 0 0 1.13
PL intron excision ratio 0 0 1.15
PL mRNA stability 0 0 1.08
pVTA alternative polyA 0 0 1.1
pVTA alternative TSS 0 0 1.14
pVTA gene expression 0 0 1.12
pVTA isoform ratio 0 0 1.1
pVTA intron excision ratio 0 0 1.14
pVTA mRNA stability 0 0 1.09
RMTg alternative polyA 0 0 0.9
RMTg alternative TSS 0 0 1.06
RMTg gene expression 0 0 1.07
RMTg isoform ratio 0 0 1.09
RMTg intron excision ratio 0 0 1.04
RMTg mRNA stability 0 0 1.02