Hub : Traits

Reaction time num false alarms

False alarms indicated by number of times that the rat pulled its snout out of the center hole and responded to the left water feeder prior to the onset of the imperative stimulus in the last three 18-minute sessions, measure of motor impulsivity, for males and females [n]

Tags: Behavior · Reaction time

Project: p50_david_dietz

10 significantly associated models · 7 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 7.9e-29 NaN NA NA NA
2 10 10636724 12342417 5 1 2.5e-08 2.6e-07 0.94 100 Slx4
3 10 61058947 62452613 1 1 6.1e-08 2.1e-03 1.00 100 Blmh

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 106.7 1 1 33 0.00 1.0e+00 NA
Body weight 5.9 2 1 33 0.00 1.0e+00 Blmh NA
Epididymis fat weight 87.6 1 1 33 0.00 1.0e+00 NA
Glucose 6.0 2 0 0 0.00 1.0e+00 Blmh NA
Heart weight 11.4 1 0 0 0.00 1.0e+00 NA
Left kidney weight 16.8 4 1 33 0.99 1.2e-03 Cluap1 Naa60 Nlrc3 NA
Right kidney weight 41.9 1 1 33 0.00 1.0e+00 NA
Tail length 15.8 6 1 33 0.92 3.6e-04 Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Length with tail 5.6 6 1 33 0.93 2.5e-04 Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Length without tail 71.1 1 1 33 0.00 1.0e+00 NA
Liver weight, left 23.6 1 1 33 0.00 1.0e+00 NA
Liver weight, right 9.6 1 0 0 0.00 1.0e+00 NA
Parametrial fat weight 26.4 1 1 33 0.00 1.0e+00 NA
Retroperitoneal fat weight 3.4 6 0 0 0.96 1.4e-04 Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Intraocular pressure 19.0 1 1 33 0.00 1.0e+00 NA
Extensor digitorum longus weight 25.8 1 1 33 0.00 1.0e+00 NA
Soleus weight 10.4 2 1 33 0.00 1.0e+00 Crebbp NA
Tibialis anterior weight 59.9 1 1 33 0.00 1.0e+00 NA
Tibia length 5.3 1 0 0 0.00 1.0e+00 NA
Number of licking bursts 155.0 1 1 33 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 9.9 6 0 0 -0.98 8.0e-05 Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Times rat made contact with spout 75.1 1 1 33 0.00 1.0e+00 NA
Mean time between licks in bursts 54.9 1 1 33 0.00 1.0e+00 NA
Mean num. licks in bursts 164.2 1 1 33 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 177.7 1 1 33 0.00 1.0e+00 NA
Indifference point 0 sec 18.7 1 1 33 0.00 1.0e+00 NA
Indifference point AUC 31.0 2 1 33 0.00 1.0e+00 Blmh NA
Delay discounting total patch changes 0 sec 17.7 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 102.7 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 175.3 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 28.3 1 1 33 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 67.6 2 1 33 0.00 1.0e+00 Blmh NA
Delay discounting time to switch 0 sec 6.3 1 0 0 0.00 1.0e+00 Blmh
Delay discounting water rate 0 sec 8.6 2 0 0 0.00 1.0e+00 Blmh NA
Delay discounting water rate 12 sec 20.1 2 1 33 0.00 1.0e+00 Blmh NA
Delay discounting water rate 18 sec 10.5 1 0 0 0.00 1.0e+00 NA
Delay discounting water rate 24 sec 62.7 1 1 33 0.00 1.0e+00 NA
Delay discounting water rate 6 sec 44.2 1 1 33 0.00 1.0e+00 NA
Locomotor testing distance 11.5 1 0 0 0.00 1.0e+00 NA
Locomotor testing rearing 16.8 1 1 33 0.00 1.0e+00 NA
Light reinforcement 1 54.8 1 1 33 0.00 1.0e+00 NA
Reaction time number correct 9.4 1 0 0 0.00 1.0e+00 NA
Reaction time num false alarms AUC 30.5 7 3 100 0.99 5.3e-09 Blmh Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Reaction time trials correct on left 9.4 1 0 0 0.00 1.0e+00 NA
Reaction time trials on left 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time mean 41.3 1 1 33 0.00 1.0e+00 NA
Reaction time mean AUC 58.0 1 1 33 0.00 1.0e+00 NA
Median of all reaction times 51.2 1 1 33 0.00 1.0e+00 NA
Reaction time false alarm rate 20.2 7 1 33 0.97 1.7e-06 Blmh Crebbp Cluap1 Naa60 Nlrc3 Slx4 NA
Reaction time premature initiation rate 32.1 1 1 33 0.00 1.0e+00 NA
Reaction time premature initiations 34.3 1 1 33 0.00 1.0e+00 NA
Std. dev. reaction times 17.4 1 1 33 0.00 1.0e+00 NA
Reaction time trials completed 10.3 1 0 0 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0 0.00 1.0e+00 NA
Social responses 74.3 1 1 33 0.00 1.0e+00 NA
Social time 7.8 1 0 0 0.00 1.0e+00 NA
Cocaine response after cond. corrected 78.0 1 1 33 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 71.3 2 1 33 0.00 1.0e+00 Blmh NA
Cocaine response before conditioning 28.6 1 1 33 0.00 1.0e+00 NA
Saline control response 30.3 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 40.7 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active responses 11.1 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. lever latency 36.3 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 88.7 2 1 33 0.00 1.0e+00 Crebbp NA
Pavlov. Cond. index score 62.2 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. latency score 67.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 29.4 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 102.6 2 1 33 0.00 1.0e+00 Crebbp NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. response bias 30.8 1 1 33 0.00 1.0e+00 NA
Conditioned reinforcement - actives 18.5 1 0 0 0.00 1.0e+00 NA
Conditioned locomotion 9.9 1 0 0 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 44.5 2 1 33 0.00 1.0e+00 Blmh NA
Intermittent access intake escalation 82.5 1 1 33 0.00 1.0e+00 NA
Intermittent access intake escalation 2 42.5 1 1 33 0.00 1.0e+00 NA
Intermitt. access day 1 inactive lever presses 19.4 1 1 33 0.00 1.0e+00 NA
Intermitt. access escalation Index 9.2 1 0 0 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 32.7 1 1 33 0.00 1.0e+00 NA
Intermittent access day 1 locomotion 18.4 1 1 33 0.00 1.0e+00 NA
Post-drug Anxiety 20.6 1 0 0 0.00 1.0e+00 NA
Baseline Anxiety 15.1 1 0 0 0.00 1.0e+00 Blmh
Progressive ratio test 1 active lever presses 11.8 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 1 breakpoint 10.4 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 1 inactive lever presses 10.8 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 2 active lever presses 12.2 1 0 0 0.00 1.0e+00 NA
Progressive ratio test 2 breakpoint 38.7 1 1 33 0.00 1.0e+00 NA
Short access day 10 total inactive lever presses 12.2 1 0 0 0.00 1.0e+00 NA
Short access day 1 total infusions 8.2 1 0 0 0.00 1.0e+00 Blmh
Short access day 10 total infusions 24.0 1 1 33 0.00 1.0e+00 NA
Short access day 1 locomotion 17.2 1 0 0 0.00 1.0e+00 NA
Compulsive drug intake 28.2 1 1 33 0.00 1.0e+00 NA
One hour access (0.3 mA shock) 10.4 1 0 0 0.00 1.0e+00 NA
Context. condit. distance diff. score 149.8 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 1 117.8 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 1 252.3 2 1 33 0.00 1.0e+00 Blmh NA
Locomotion velocity, session 2 82.2 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 2 776.0 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 3 116.1 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 3 82.4 1 1 33 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 3 8.8 1 0 0 0.00 1.0e+00 NA
Stereotopy head waving duration, day 3 25.6 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, session 7 66.3 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 7 21.3 1 1 33 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 42.6 1 1 33 0.00 1.0e+00 NA
Stereotopy head waving duration, day 7 63.4 1 1 33 0.00 1.0e+00 NA
Locomotion distance, session 8 102.8 1 1 33 0.00 1.0e+00 NA
Degree of sensitization distance 140.6 1 1 33 0.00 1.0e+00 NA
Degree of sensitization stereotypy 22.9 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 33 0.00 1.0e+00 NA
Condit. Reinf. active responses 20.0 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 17.2 1 0 0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 33 0.00 1.0e+00 NA
Time in familiar zone, hab. session 1 16.4 1 0 0 0.00 1.0e+00 NA
Time in novel zone, hab. session 1 12.9 1 0 0 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 279.8 2 1 33 0.00 1.0e+00 Blmh NA
Total locomotion distance, hab. session 1 171.4 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, hab. session 1 218.6 1 1 33 0.00 1.0e+00 NA
Time in familiar zone, hab. session 2 48.9 1 1 33 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 34.1 1 1 33 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 173.5 2 1 33 0.00 1.0e+00 Blmh NA
Total locomotion distance, hab. session 2 133.1 1 1 33 0.00 1.0e+00 NA
Locomotion velocity, hab. session 2 139.4 1 1 33 0.00 1.0e+00 NA
Total zone transitions, NPP test 154.7 2 1 33 0.00 1.0e+00 Blmh NA
Total locomotion distance, NPP test 112.5 2 1 33 0.00 1.0e+00 Blmh NA
Locomotion velocity, NPP test 133.5 2 1 33 0.00 1.0e+00 Blmh NA
Pavlov. Cond. lever latency 8.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 56.4 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 13.3 1 0 0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 34.9 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 33 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 33 0.00 1.0e+00 NA
Bone: apparent density 18.6 1 1 33 0.00 1.0e+00 NA
Bone surface 28.9 1 1 33 0.00 1.0e+00 NA
Bone volume 32.3 1 1 33 0.00 1.0e+00 NA
Bone: connectivity density 8.5 1 0 0 0.00 1.0e+00 NA
Bone: cortical porosity 48.6 3 1 33 -0.55 3.3e-01 Nlrc3 Slx4 NA
Bone: cortical porosity 63.3 2 1 33 0.00 1.0e+00 Nlrc3 NA
Bone: cortical thickness 8.8 1 0 0 0.00 1.0e+00 NA
Bone: cortical thickness 17.9 1 0 0 0.00 1.0e+00 NA
Bone: elastic displacement 18.4 2 1 33 0.00 1.0e+00 Blmh NA
Bone: elastic work 13.5 1 0 0 0.00 1.0e+00 Blmh
Bone: endosteal estimation 12.7 1 1 33 0.00 1.0e+00 NA
Bone: final force 39.5 1 1 33 0.00 1.0e+00 NA
Bone: final moment 31.9 1 1 33 0.00 1.0e+00 NA
Bone: marrow area 10.6 1 1 33 0.00 1.0e+00 NA
Bone: maximum force 42.0 1 1 33 0.00 1.0e+00 NA
Bone: maximum moment 29.5 1 1 33 0.00 1.0e+00 NA
Bone: minimum diameter 57.3 1 1 33 0.00 1.0e+00 NA
Bone: periosteal estimation 7.8 1 0 0 0.00 1.0e+00 NA
Bone: periosteal perimeter 8.8 1 0 0 0.00 1.0e+00 NA
Bone: post-yield work 82.8 1 1 33 0.00 1.0e+00 NA
Bone: stiffness 90.4 1 1 33 0.00 1.0e+00 NA
Bone: tissue strength 81.0 1 1 33 0.00 1.0e+00 NA
Bone: trabecular number 39.4 1 1 33 0.00 1.0e+00 NA
Bone: trabecular thickness 10.4 1 0 0 0.00 1.0e+00 NA
Bone: trabecular tissue density 43.1 1 1 33 0.00 1.0e+00 NA
Distance traveled before self-admin 12.6 1 0 0 0.00 1.0e+00 NA
Delta time in open arm before/after self-admin 40.2 1 1 33 0.00 1.0e+00 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0.00 1.0e+00 NA
Active lever presses in extinction session 6 9.2 1 0 0 0.00 1.0e+00 NA
Delta distance traveled before/after self-admin 11.3 1 0 0 0.00 1.0e+00 NA
Time in closed arm before self-admin 50.0 1 1 33 0.00 1.0e+00 NA
Time in closed arm after self-admin 25.8 1 1 33 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 33 0.00 1.0e+00 NA
Time to tail flick, vehicle, after self-admin 7.4 1 0 0 0.00 1.0e+00 Slx4
Delta time to tail flick, test, before/after SA 20.0 1 0 0 0.00 1.0e+00 NA
Delay disc. indifference point, 0s delay 7.6 1 0 0 0.00 1.0e+00 Blmh
Fecal boli incidents, locomotor time 1 11.5 2 0 0 0.00 1.0e+00 Blmh NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 2 19.4 1 1 33 0.00 1.0e+00 NA
Rest time, locomotor task time 2 8.8 1 0 0 0.00 1.0e+00 NA
Distance moved, locomotor task time 2 13.1 1 0 0 0.00 1.0e+00 NA
Weight adjusted by age 16.7 1 1 33 0.00 1.0e+00 NA
Locomotion in novel chamber 10.2 1 0 0 0.00 1.0e+00 NA
Run reversals in cocaine runway, males 25.4 1 1 33 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 18.8 1 0 0 0.00 1.0e+00 NA
Cd content in liver 140.5 1 1 33 0.00 1.0e+00 NA
Co content in liver 83.2 1 1 33 0.00 1.0e+00 NA
Fe content in liver 10.3 1 0 0 0.00 1.0e+00 NA
K content in liver 44.8 2 1 33 0.00 1.0e+00 Crebbp NA
Mn content in liver 130.2 1 1 33 0.00 1.0e+00 NA
Rb content in liver 31.4 1 1 33 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 33 0.00 1.0e+00 NA
Zn content in liver 46.0 1 1 33 0.00 1.0e+00 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.3
Adipose alternative TSS 1 0.062 1.4
Adipose gene expression 1 0.012 1.4
Adipose isoform ratio 0 0.000 1.4
Adipose intron excision ratio 0 0.000 1.3
Adipose mRNA stability 1 0.029 1.4
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.6
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.4
BLA mRNA stability 0 0.000 1.4
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 0 0.000 1.4
Brain gene expression 1 0.011 1.4
Brain isoform ratio 0 0.000 1.4
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.3
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.4
Eye gene expression 0 0.000 1.4
Eye isoform ratio 0 0.000 1.3
Eye intron excision ratio 0 0.000 1.4
Eye mRNA stability 0 0.000 1.6
IL alternative polyA 0 0.000 1.5
IL alternative TSS 0 0.000 1.4
IL gene expression 0 0.000 1.4
IL isoform ratio 0 0.000 1.4
IL intron excision ratio 0 0.000 1.4
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.2
LHb gene expression 0 0.000 1.4
LHb isoform ratio 0 0.000 1.4
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.5
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.4
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.3
Liver intron excision ratio 2 0.046 1.3
Liver mRNA stability 0 0.000 1.3
NAcc alternative polyA 0 0.000 1.4
NAcc alternative TSS 1 0.108 1.5
NAcc gene expression 0 0.000 1.4
NAcc isoform ratio 0 0.000 1.4
NAcc intron excision ratio 0 0.000 1.3
NAcc mRNA stability 0 0.000 1.4
OFC alternative polyA 0 0.000 1.6
OFC alternative TSS 0 0.000 1.3
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.4
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.6
PL gene expression 0 0.000 1.4
PL isoform ratio 2 0.090 1.4
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 1 0.034 1.3

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.