Hub : Traits

Reaction time num false alarms

False alarms indicated by number of times that the rat pulled its snout out of the center hole and responded to the left water feeder prior to the onset of the imperative stimulus in the last three 18-minute sessions, measure of motor impulsivity, for males and females [n]

Tags: Behavior · Reaction time

Project: p50_david_dietz

1 locus · 1 gene with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr10	10440673	12310348	3	1	5.43e-08	2.58e-07	1e+00	Slx4

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	1.81	2	0	0	0	1.00e+00	Adcy9 Slx4
Left kidney weight	2.74	2	0	0	0	1.00e+00	Cluap1 Slx4
Right kidney weight	2.35	1	0	0	0	1.00e+00	Cluap1
Tail length	3.65	3	0	0	1	6.07e-04	Adcy9 Cluap1 Slx4
Length with tail	6.32	3	0	0	1	1.59e-04	Adcy9 Cluap1 Slx4
Retroperitoneal fat weight	3.56	3	0	0	1	2.15e-03	Adcy9 Cluap1 Slx4
Soleus weight	3.75	2	0	0	0	1.00e+00	Adcy9 Slx4
Food consumed during 24 hour testing period	8.46	3	0	0	-1	3.30e-03	Adcy9 Cluap1 Slx4
Reaction time num false alarms AUC	19.27	3	2	200	1	7.71e-05	Adcy9 Cluap1 Slx4
Reaction time false alarm rate	11.1	3	0	0	1	1.44e-03	Adcy9 Cluap1 Slx4
Condit. Reinf. lever presses	4.66	1	0	0	0	1.00e+00	Slx4
Condit. Reinf. lever reinforcers received	4.62	1	0	0	0	1.00e+00	Slx4
Pavlov. Cond. magazine entry latency	6.54	1	0	0	0	1.00e+00	Adcy9
Pavlov. Cond. change in total contacts	5.65	2	0	0	0	1.00e+00	Adcy9 Slx4
Pavlov. Cond. index score	5.93	2	0	0	0	1.00e+00	Adcy9 Slx4
Pavlov. Cond. latency score	5.94	2	0	0	0	1.00e+00	Adcy9 Slx4
Pavlov. Cond. magazine entry number	7.33	2	0	0	0	1.00e+00	Adcy9 Slx4
Pavlov. Cond. lever-magazine prob. diff.	5.63	2	0	0	0	1.00e+00	Adcy9 Slx4
Incentive Sensitization - Responses	6.49	1	0	0	0	1.00e+00	Slx4
Incentive Sensitization - Breakpoint	6.42	1	0	0	0	1.00e+00	Slx4
Bone: cortical porosity	7.41	3	0	0	1	9.30e-04	Adcy9 Cluap1 Slx4
Bone: cortical porosity	7.26	2	0	0	0	1.00e+00	Cluap1 Slx4
Time to tail flick, vehicle, after self-admin	7.31	2	0	0	0	1.00e+00	Cluap1 Slx4
Bouts of movement, locomotor time 1	7.19	2	0	0	0	1.00e+00	Cluap1 Slx4
Weight adjusted by age	5.73	1	0	0	0	1.00e+00	Slx4
K content in liver	8.92	2	0	0	0	1.00e+00	Adcy9 Slx4

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.35
Adipose	alternative TSS	0	0	1.28
Adipose	gene expression	0	0	1.37
Adipose	isoform ratio	0	0	1.37
Adipose	intron excision ratio	0	0	1.32
Adipose	mRNA stability	0	0	1.33
BLA	alternative polyA	0	0	1.32
BLA	alternative TSS	0	0	1.4
BLA	gene expression	0	0	1.38
BLA	isoform ratio	0	0	1.39
BLA	intron excision ratio	0	0	1.35
BLA	mRNA stability	0	0	1.33
Brain	alternative polyA	0	0	1.32
Brain	alternative TSS	0	0	1.38
Brain	gene expression	0	0	1.39
Brain	isoform ratio	0	0	1.39
Brain	intron excision ratio	0	0	1.4
Brain	mRNA stability	0	0	1.33
Eye	alternative polyA	0	0	1
Eye	alternative TSS	0	0	1.53
Eye	gene expression	0	0	1.32
Eye	isoform ratio	0	0	1.36
Eye	intron excision ratio	0	0	1.33
Eye	mRNA stability	0	0	1.44
IL	alternative polyA	0	0	1.31
IL	alternative TSS	0	0	1.16
IL	gene expression	0	0	1.39
IL	isoform ratio	0	0	1.39
IL	intron excision ratio	0	0	1.47
IL	mRNA stability	0	0	1.35
LHb	alternative polyA	0	0	1.27
LHb	alternative TSS	0	0	1.21
LHb	gene expression	0	0	1.42
LHb	isoform ratio	0	0	1.36
LHb	intron excision ratio	0	0	1.31
LHb	mRNA stability	0	0	1.42
Liver	alternative polyA	0	0	1.34
Liver	alternative TSS	0	0	1.31
Liver	gene expression	0	0	1.38
Liver	isoform ratio	1	0	1.27
Liver	intron excision ratio	0	0	1.34
Liver	mRNA stability	0	0	1.3
NAcc	alternative polyA	0	0	1.3
NAcc	alternative TSS	0	0	1.3
NAcc	gene expression	0	0	1.37
NAcc	isoform ratio	0	0	1.41
NAcc	intron excision ratio	0	0	1.39
NAcc	mRNA stability	1	0	1.33
OFC	alternative polyA	0	0	1.44
OFC	alternative TSS	0	0	1.52
OFC	gene expression	0	0	1.38
OFC	isoform ratio	0	0	1.43
OFC	intron excision ratio	0	0	1.29
OFC	mRNA stability	0	0	1.37
PL	alternative polyA	0	0	1.29
PL	alternative TSS	0	0	1.4
PL	gene expression	0	0	1.39
PL	isoform ratio	0	0	1.39
PL	intron excision ratio	0	0	1.37
PL	mRNA stability	2	0.1	1.36
pVTA	alternative polyA	0	0	1.36
pVTA	alternative TSS	0	0	1.34
pVTA	gene expression	0	0	1.36
pVTA	isoform ratio	0	0	1.36
pVTA	intron excision ratio	0	0	1.33
pVTA	mRNA stability	0	0	1.4
RMTg	alternative polyA	0	0	1.18
RMTg	alternative TSS	0	0	1.28
RMTg	gene expression	0	0	1.41
RMTg	isoform ratio	0	0	1.36
RMTg	intron excision ratio	0	0	1.47
RMTg	mRNA stability	0	0	1.44