Hub : Traits

Time to tail flick, test, before self-admin

Time in sec to remove tail from noxious stimuli under test conditions in the first tail flick before self admin

Tags: Behavior · Heroin

Project: u01_peter_kalivas

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	68674594	70070028	1	1	1.66e-07	8.20e-02	1.87e-55	Rdh13
2	chr1	72799368	74100561	1	1	1.40e-07	3.48e-02	7.29e-17	Zfp329

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Epididymis fat weight	2.97	1	0	0	0	1e+00	Rdh13
Glucose	4.51	1	0	0	0	1e+00	Rdh13
Left kidney weight	1.89	1	0	0	0	1e+00	Rdh13
Liver weight, left	5.33	1	0	0	0	1e+00	Zfp329
Patch foraging indifference point 0 sec	7.02	1	0	0	0	1e+00	Rdh13
Indifference point function ln k	7.47	1	0	0	0	1e+00	Rdh13
Indifference point function log k	7.47	1	0	0	0	1e+00	Rdh13
Patch foraging total patch changes 0 sec	6.22	1	0	0	0	1e+00	Rdh13
Patch foraging total patch changes 24 sec	5.85	1	0	0	0	1e+00	Rdh13
Patch foraging time to switch 0 sec	12.3	2	0	0	0	1e+00	Rdh13 Zfp329
Patch foraging water rate 0 sec	4.08	1	0	0	0	1e+00	Zfp329
Patch foraging water rate 12 sec	8.55	2	0	0	0	1e+00	Rdh13 Zfp329
Patch foraging water rate 18 sec	4.45	1	0	0	0	1e+00	Rdh13
Patch foraging water rate 24 sec	4.17	1	0	0	0	1e+00	Rdh13
Light reinforcement 1	7.49	1	0	0	0	1e+00	Rdh13
Reaction time num false alarms AUC	7.18	1	0	0	0	1e+00	Rdh13
Reaction time mean	3.94	1	0	0	0	1e+00	Zfp329
Reaction time mean AUC	4.39	2	0	0	0	1e+00	Rdh13 Zfp329
Reaction time false alarm rate	4.45	1	0	0	0	1e+00	Rdh13
Social time	5.77	1	0	0	0	1e+00	Zfp329
Conditioned locomotion	8.76	1	0	0	0	1e+00	Rdh13
Cocaine response after cond. corrected	6.66	1	0	0	0	1e+00	Zfp329
Cocaine response before conditioning	4.36	1	0	0	0	1e+00	Zfp329
Saline control response	14.29	1	0	0	0	1e+00	Rdh13
Condit. Reinf. active-inactive response ratio	6.11	1	0	0	0	1e+00	Rdh13
Condit. Reinf. inactive responses	6.92	1	0	0	0	1e+00	Rdh13
Pavlov. Cond. lever latency	3.93	2	0	0	0	1e+00	Rdh13 Zfp329
Pavlov. Cond. change in total contacts	6.37	2	0	0	0	1e+00	Rdh13 Zfp329
Conditioned reinforcement - actives	9.76	1	0	0	0	1e+00	Rdh13
Conditioned locomotion	6	1	0	0	0	1e+00	Zfp329
Intermittent access intake day 1-15 change	5.83	1	0	0	0	1e+00	Rdh13
Intermitt. access day 1 inactive lever presses	14.57	2	0	0	0	1e+00	Rdh13 Zfp329
Intermitt. access day 15 inactive lever presses	11.3	2	0	0	0	1e+00	Rdh13 Zfp329
Intermitt. access escalation Index	54.57	1	1	50	0	1e+00	Rdh13
Intermittent access standard deviation	7.82	1	0	0	0	1e+00	Zfp329
Post-drug Anxiety	4.85	1	0	0	0	1e+00	Zfp329
Baseline Anxiety	7.91	2	0	0	0	1e+00	Rdh13 Zfp329
Incentive Sensitization - Breakpoint	5.27	1	0	0	0	1e+00	Zfp329
Short access day 1 total inactive lever presses	6.03	1	0	0	0	1e+00	Zfp329
One hour access (shock baseline)	7.71	1	0	0	0	1e+00	Zfp329
Number of responses in last shaping day	13.68	1	0	0	0	1e+00	Rdh13
Locomotion velocity, session 1	12.03	1	0	0	0	1e+00	Rdh13
Locomotion distance, session 1	5.22	1	0	0	0	1e+00	Rdh13
Locomotion velocity, session 8	5.38	1	0	0	0	1e+00	Rdh13
Time in familiar zone, hab. session 1	9.33	1	0	0	0	1e+00	Zfp329
Time in novel zone, hab. session 1	8.5	1	0	0	0	1e+00	Zfp329
Total zone transitions, hab. session 1	4.15	1	0	0	0	1e+00	Rdh13
Time in familiar zone, hab. session 2	5.59	1	0	0	0	1e+00	Rdh13
Locomotion velocity, hab. session 2	4.26	1	0	0	0	1e+00	Zfp329
Pavlov. Cond. intertrial magazine entries	10.61	1	0	0	0	1e+00	Rdh13
Bone: endosteal estimation	2.55	1	0	0	0	1e+00	Rdh13
Bone: marrow area	2.64	1	0	0	0	1e+00	Rdh13
Bone: tissue strength	6.53	1	0	0	0	1e+00	Zfp329
Bone: trabecular tissue density	8.11	1	0	0	0	1e+00	Zfp329
Breakpoint value in progressive ratio session	4.72	1	0	0	0	1e+00	Rdh13
Distance traveled before self-admin	7.47	2	0	0	0	1e+00	Rdh13 Zfp329
Distance traveled after self-admin	10.74	2	0	0	0	1e+00	Rdh13 Zfp329
Delta time in open arm before/after self-admin	19.63	1	0	0	0	1e+00	Rdh13
Diff in mean of infusions in LGA sessions	11.6	2	0	0	0	1e+00	Rdh13 Zfp329
Extinction: sum of active levers before priming	13.43	2	0	0	0	1e+00	Rdh13 Zfp329
Active lever presses in extinction session 6	11.29	2	0	0	0	1e+00	Rdh13 Zfp329
Delta distance traveled before/after self-admin	7.48	1	0	0	0	1e+00	Rdh13
Time in closed arm after self-admin	5	1	0	0	0	1e+00	Rdh13
Time in open arm after self-admin	15.55	1	0	0	0	1e+00	Rdh13
Sum of active levers in priming session hrs 5-6	17.64	1	0	0	0	1e+00	Rdh13
Time to tail flick, vehicle, after self-admin	12.61	1	0	0	0	1e+00	Rdh13
Delta time to tail flick, vehicle, before/after SA	24.61	1	0	0	0	1e+00	Rdh13
Delta time to tail flick, test, before/after SA	12.78	2	0	0	0	1e+00	Rdh13 Zfp329
Ambulatory time before self-admin	10.11	2	0	0	0	1e+00	Rdh13 Zfp329
Ambulatory time after self-admin	12.62	2	0	0	0	1e+00	Rdh13 Zfp329
Delay disc. indifference point, 0s delay	11.11	2	0	0	0	1e+00	Rdh13 Zfp329
Delay disc. indifference point, 16s delay	7.07	2	0	0	0	1e+00	Rdh13 Zfp329
Bouts of movement, locomotor time 1	6.2	2	0	0	0	1e+00	Rdh13 Zfp329
Vertical activity count, locomotor time 1	13.87	1	0	0	0	1e+00	Rdh13
Seeking ratio, delayed vs. immediate footshock	8.8	2	0	0	0	1e+00	Rdh13 Zfp329
Locomotion in novel chamber	4.79	1	0	0	0	1e+00	Rdh13
Food seeking constrained by brief footshock	38.97	2	2	100	0	1e+00	Rdh13 Zfp329
Seeking ratio, punishment vs. effort	7.45	2	0	0	0	1e+00	Rdh13 Zfp329
Run reversals in cocaine runway, females	5.73	1	0	0	0	1e+00	Rdh13
Na content in liver	7.32	1	0	0	0	1e+00	Rdh13
Sr content in liver	16.58	2	0	0	0	1e+00	Rdh13 Zfp329

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.01
Adipose	alternative TSS	0	0	0.96
Adipose	gene expression	0	0	1.01
Adipose	isoform ratio	0	0	0.94
Adipose	intron excision ratio	0	0	0.92
Adipose	mRNA stability	0	0	1.02
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	0.86
BLA	gene expression	0	0	1
BLA	isoform ratio	0	0	0.97
BLA	intron excision ratio	0	0	0.96
BLA	mRNA stability	0	0	0.96
Brain	alternative polyA	0	0	1
Brain	alternative TSS	0	0	0.93
Brain	gene expression	0	0	1.01
Brain	isoform ratio	0	0	0.99
Brain	intron excision ratio	0	0	0.96
Brain	mRNA stability	0	0	1.01
Eye	alternative polyA	0	0	1.04
Eye	alternative TSS	0	0	1.19
Eye	gene expression	0	0	0.98
Eye	isoform ratio	0	0	1.01
Eye	intron excision ratio	0	0	0.91
Eye	mRNA stability	0	0	0.92
IL	alternative polyA	0	0	0.95
IL	alternative TSS	0	0	0.93
IL	gene expression	0	0	0.98
IL	isoform ratio	0	0	0.97
IL	intron excision ratio	0	0	0.94
IL	mRNA stability	0	0	0.97
LHb	alternative polyA	0	0	0.86
LHb	alternative TSS	0	0	0.86
LHb	gene expression	0	0	0.98
LHb	isoform ratio	0	0	0.97
LHb	intron excision ratio	0	0	0.9
LHb	mRNA stability	0	0	1.02
Liver	alternative polyA	0	0	0.91
Liver	alternative TSS	0	0	0.96
Liver	gene expression	0	0	1.01
Liver	isoform ratio	0	0	0.96
Liver	intron excision ratio	1	0	0.95
Liver	mRNA stability	0	0	1.01
NAcc	alternative polyA	0	0	0.98
NAcc	alternative TSS	0	0	0.94
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	0.96
NAcc	intron excision ratio	0	0	0.95
NAcc	mRNA stability	0	0	0.97
OFC	alternative polyA	0	0	0.98
OFC	alternative TSS	0	0	0.87
OFC	gene expression	0	0	0.98
OFC	isoform ratio	0	0	1.04
OFC	intron excision ratio	0	0	0.93
OFC	mRNA stability	0	0	0.96
PL	alternative polyA	1	0	0.99
PL	alternative TSS	0	0	0.93
PL	gene expression	0	0	1.04
PL	isoform ratio	0	0	0.98
PL	intron excision ratio	0	0	0.94
PL	mRNA stability	0	0	1
pVTA	alternative polyA	0	0	0.98
pVTA	alternative TSS	0	0	0.87
pVTA	gene expression	0	0	1.01
pVTA	isoform ratio	0	0	0.98
pVTA	intron excision ratio	0	0	0.97
pVTA	mRNA stability	0	0	1.03
RMTg	alternative polyA	0	0	0.82
RMTg	alternative TSS	0	0	0.89
RMTg	gene expression	0	0	0.98
RMTg	isoform ratio	0	0	0.93
RMTg	intron excision ratio	0	0	0.99
RMTg	mRNA stability	0	0	0.99