Hub : Genes

Tmem179

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000013128 0.15 0.09 1.6e-12 0.1 0.09 0.1 0.1 8.4e-11 6.7e-10 8.7e-11 1.1e-10
2 OFC gene expression ENSRNOG00000013128 0.18 0.13 3.2e-04 0.06 0.09 0.04 0.05 1.3e-02 3.1e-03 3.2e-02 3.0e-02
3 PL gene expression ENSRNOG00000013128 0.08 0.07 5.9e-04 0.04 0.04 0.03 0.03 1.0e-03 4.3e-04 1.3e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.47.88.7-3.0-2.8-2.6
BMI without tail0.71.51.7-1.2-1.2-1.3
Body weight0.83.35.51.31.62.3
Epididymis fat weight3.48.09.2-3.0-3.0-2.4
Glucose0.20.30.50.60.70.1
Heart weight0.00.00.00.1-0.0-0.2
Left kidney weight2.36.58.92.22.43.0
Right kidney weight1.44.15.41.91.92.3
Tail length4.714.315.93.63.84.0
Length with tail7.527.533.84.75.15.8
Length without tail4.18.911.92.62.93.5
Liver weight, left2.13.43.91.72.01.8
Liver weight, right0.10.20.40.00.30.6
Parametrial fat weight0.00.10.1-0.2-0.3-0.4
Retroperitoneal fat weight0.20.71.0-1.0-0.8-0.5
Intraocular pressure0.00.10.1-0.1-0.2-0.4
Extensor digitorum longus weight8.233.138.75.35.76.2
Soleus weight0.61.84.50.50.92.1
Tibialis anterior weight0.51.93.01.01.31.7
Tibia length0.00.10.30.30.50.2
Number of licking bursts0.30.30.8-0.2-0.3-0.9
Food consumed during 24 hour testing period0.60.71.20.60.81.1
Times rat made contact with spout0.10.10.10.20.40.3
Mean time between licks in bursts0.40.60.8-0.6-0.9-0.7
Mean num. licks in bursts0.40.41.00.30.51.0
Std. dev. time between licks in bursts0.10.10.30.0-0.10.6
Water consumed over 24 hours2.32.73.31.71.81.4
Indifference point 0 sec4.77.68.82.52.83.0
Indifference point AUC2.63.04.61.21.82.1
Indifference point function ln k1.21.62.11.51.21.1
Indifference point function log k1.21.62.11.51.21.1
Delay discounting total patch changes 0 sec5.69.010.72.73.03.3
Delay discounting total patch changes 12 sec3.54.65.32.02.32.2
Delay discounting total patch changes 18 sec1.31.72.30.91.41.5
Delay discounting total patch changes 24 sec0.40.50.90.40.71.0
Delay discounting total patch changes 6 sec2.63.95.91.42.02.4
Delay discounting time to switch 0 sec10.916.718.0-4.0-4.2-4.1
Delay discounting water rate 0 sec17.728.231.35.25.65.1
Delay discounting water rate 12 sec9.914.817.54.24.03.3
Delay discounting water rate 18 sec5.06.67.52.62.72.3
Delay discounting water rate 24 sec4.15.76.32.52.52.2
Delay discounting water rate 6 sec4.86.97.72.62.82.5
Locomotor activity0.10.20.30.50.50.5
Locomotor testing distance0.20.40.60.70.80.5
Locomotor testing rearing1.82.93.1-1.7-1.6-1.8
Light reinforcement 10.00.00.00.10.10.1
Light reinforcement 22.02.62.9-1.6-1.7-1.5
Reaction time number correct3.75.45.52.22.42.4
Reaction time mean minus median0.10.10.1-0.3-0.3-0.1
Reaction time mean minus median AUC0.00.00.0-0.1-0.20.1
Reaction time num false alarms1.21.61.81.11.31.4
Reaction time num false alarms AUC1.52.02.31.31.51.4
Reaction time trials correct on left3.75.45.52.22.42.4
Reaction time trials on left3.85.45.72.22.42.4
Reaction time mean0.91.31.7-0.9-1.2-1.3
Reaction time mean AUC0.50.60.8-0.6-0.9-0.9
Median of all reaction times0.50.71.2-0.6-0.9-1.1
Reaction time omissions1.31.71.81.21.31.3
Reaction time false alarm rate0.10.10.10.20.30.2
Reaction time premature initiation rate0.60.81.21.10.90.6
Reaction time premature initiations2.53.64.12.01.91.8
Std. dev. reaction times0.50.70.9-0.6-0.8-1.0
Reaction time trials completed3.85.45.72.22.42.4
Reaction time trials AUC4.05.75.92.32.42.4
Social response proportion0.20.20.40.60.4-0.3
Social responses0.10.10.3-0.2-0.2-0.5
Social time1.31.73.01.71.30.7
Conditioned locomotion1.41.71.91.21.31.4
Cocaine response after cond. corrected0.70.81.3-1.2-0.9-0.5
Cocaine response after cond. not corrected1.92.13.1-1.8-1.5-1.0
Cocaine response before conditioning2.02.42.6-1.4-1.6-1.6
Saline control response0.00.10.1-0.1-0.00.4
Condit. Reinf. active minus inactive responses0.91.11.41.21.01.0
Condit. Reinf. active-inactive response ratio0.70.81.21.10.90.7
Condit. Reinf. active responses0.10.10.20.40.30.2
Condit. Reinf. inactive responses0.40.50.6-0.8-0.7-0.6
Condit. Reinf. lever presses0.81.11.4-0.8-1.2-1.2
Condit. Reinf. lever reinforcers received0.10.20.30.60.40.3
Pavlov. Cond. lever latency1.62.12.51.21.61.6
Pavlov. Cond. magazine entry latency3.64.24.7-2.1-2.2-1.9
Pavlov. Cond. change in total contacts4.15.86.6-2.2-2.5-2.6
Pavlov. Cond. index score3.44.45.1-2.0-2.3-2.1
Pavlov. Cond. latency score3.44.35.1-2.0-2.2-2.0
Pavlov. Cond. lever contacts2.23.03.5-1.6-1.9-1.8
Pavlov. Cond. magazine entry number2.73.33.81.81.91.7
Pavlov. Cond. intertrial magazine entries5.16.67.32.62.72.4
Pavlov. Cond. lever-magazine prob. diff.4.05.25.9-2.1-2.4-2.2
Pavlov. Cond. response bias2.43.33.9-1.7-2.0-1.8
Conditioned reinforcement - actives1.91.82.21.51.41.1
Conditioned reinforcement - inactives0.40.50.50.70.70.7
Conditioned locomotion0.20.20.3-0.5-0.6-0.2
Intermittent access intake day 1-15 change1.71.71.8-1.3-1.3-1.3
Intermittent access intake escalation1.71.71.8-1.3-1.3-1.2
Intermittent access intake escalation 20.40.40.4-0.6-0.6-0.6
Intermitt. access day 1 inactive lever presses3.43.63.71.91.91.9
Intermitt. access day 15 inactive lever presses1.01.11.31.11.10.9
Intermitt. access escalation Index0.20.20.20.50.50.2
Intermittent access day 1 total infusions0.10.10.1-0.4-0.30.1
Intermittent access day 15 total infusions1.51.61.9-1.4-1.4-1.1
Intermittent access terminal intake (last 3 days)2.02.12.5-1.6-1.5-1.3
Intermittent access total infusions0.40.40.6-0.8-0.7-0.4
Intermittent access day 1 locomotion0.30.30.4-0.6-0.6-0.2
Intermittent access day 15 total locomotion0.10.10.1-0.2-0.3-0.1
Intermittent access total locomotion0.10.10.3-0.5-0.40.0
Intermittent access standard deviation2.72.94.0-2.0-1.8-1.2
Cocaine induced anxiety1.41.62.11.41.40.8
Post-drug Anxiety0.91.01.41.21.10.6
Baseline Anxiety1.41.51.9-1.4-1.3-1.0
Lifetime Intake0.10.20.2-0.5-0.4-0.3
Incentive Sensitization - Responses0.00.00.00.0-0.1-0.2
Incentive Sensitization - Breakpoint0.00.00.00.20.1-0.1
Progressive ratio test 1 active lever presses0.00.00.0-0.1-0.1-0.2
Progressive ratio test 1 breakpoint0.10.10.1-0.4-0.3-0.3
Progressive ratio test 1 inactive lever presses2.93.13.51.71.91.6
Progressive ratio test 2 active lever presses0.00.00.0-0.0-0.0-0.1
Progressive ratio test 2 breakpoint0.00.00.00.10.10.1
Progressive ratio test 2 inactive lever presses0.50.61.01.00.90.4
Total sessions with >9 infusions0.00.00.0-0.0-0.1-0.2
Short access day 1 total inactive lever presses0.10.10.20.40.10.1
Short access day 10 total inactive lever presses0.70.81.01.00.90.8
Short access day 1 total infusions0.20.30.50.70.50.2
Short access day 10 total infusions0.20.30.3-0.5-0.5-0.5
Short access total infusions0.20.20.4-0.3-0.5-0.7
Short access day 1 locomotion0.30.30.4-0.5-0.6-0.5
Short access day 10 total locomotion0.40.40.7-0.8-0.6-0.3
Short access total locomotion0.00.00.0-0.2-0.2-0.2
Compulsive drug intake0.10.10.40.20.20.6
One hour access (0.3 mA shock)0.20.20.40.30.40.6
One hour access (shock baseline)0.00.10.1-0.2-0.2-0.3
Number of responses in last shaping day0.50.50.6-0.7-0.7-0.7
Context. condit. distance diff. score4.15.05.62.22.12.4
Locomotion velocity, session 10.20.20.20.40.40.5
Locomotion distance, session 10.50.60.8-0.9-0.8-0.6
Locomotion velocity, session 20.00.00.1-0.0-0.1-0.3
Locomotion distance, session 20.30.40.5-0.6-0.7-0.7
Locomotion velocity, session 30.10.10.2-0.4-0.3-0.0
Locomotion distance, session 30.00.00.00.00.10.0
Stereotopy head waving bouts, day 30.00.00.10.20.20.1
Stereotopy head waving duration, day 30.10.10.20.40.40.2
Locomotion velocity, session 70.10.10.2-0.4-0.4-0.1
Locomotion distance, session 70.60.81.0-0.8-1.0-0.9
Stereotopy head waving bouts, day 71.71.92.61.11.41.6
Stereotopy head waving duration, day 70.80.91.40.70.91.2
Locomotion velocity, session 81.41.62.71.01.11.6
Locomotion distance, session 80.40.71.20.70.61.1
Degree of sensitization distance0.30.30.4-0.4-0.5-0.6
Degree of sensitization stereotypy0.40.50.80.40.70.9
Condit. Reinf. active minus inactive responses0.60.70.9-0.9-0.8-0.6
Condit. Reinf. active-inactive response ratio2.52.73.0-1.7-1.7-1.5
Condit. Reinf. active responses0.10.10.3-0.5-0.3-0.0
Condit. Reinf. inactive responses1.72.02.31.21.51.5
Incentive salience index mean0.40.50.9-0.9-0.7-0.3
Condit. Reinf. lever presses0.10.10.3-0.5-0.30.1
Time in familiar zone, hab. session 10.00.00.0-0.0-0.20.2
Time in novel zone, hab. session 10.50.50.8-0.7-0.6-0.9
Total zone transitions, hab. session 10.10.20.3-0.2-0.5-0.5
Total locomotion distance, hab. session 10.40.60.90.90.70.6
Locomotion velocity, hab. session 10.91.31.61.21.11.0
Time in familiar zone, hab. session 20.10.10.2-0.4-0.20.4
Time in novel zone, hab. session 20.30.30.6-0.3-0.5-0.8
Total zone transitions, hab. session 20.50.71.0-1.0-0.9-0.5
Total locomotion distance, hab. session 20.30.30.50.50.70.6
Locomotion velocity, hab. session 20.40.50.70.60.80.7
Novel to familiar place preference ratio0.70.70.7-0.8-0.8-0.9
Novelty place preference0.50.50.7-0.6-0.7-0.8
Time in novel zone, NPP test0.20.20.2-0.5-0.5-0.5
Total zone transitions, NPP test0.30.41.00.30.31.0
Total locomotion distance, NPP test0.40.50.80.60.60.9
Locomotion velocity, NPP test0.30.40.60.60.60.8
Pavlov. Cond. lever latency0.50.71.01.00.90.5
Pavlov. Cond. magazine entry latency0.30.40.6-0.8-0.7-0.4
Pavlov. Cond. change in total contacts0.20.20.4-0.6-0.4-0.2
Pavlov. Cond. index score0.70.91.4-1.2-1.0-0.6
Pavlov. Cond. latency score0.50.71.1-1.0-0.9-0.5
Pavlov. Cond. lever contacts1.11.41.7-1.3-1.2-1.0
Pavlov. Cond. magazine entry number0.50.60.91.00.90.3
Pavlov. Cond. intertrial magazine entries7.28.610.02.72.93.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.1-1.1-0.9-0.5
Pavlov. Cond. response bias0.70.81.3-1.1-1.0-0.4
Bone: apparent density0.00.00.0-0.1-0.10.2
Bone surface0.10.10.1-0.2-0.3-0.4
Bone volume0.00.10.1-0.2-0.2-0.3
Bone: connectivity density0.40.60.80.70.60.9
Bone: cortical apparent density6.07.99.52.93.12.4
Bone: cortical area0.20.30.50.40.70.4
Bone: cortical porosity0.40.40.50.70.50.7
Bone: cortical porosity0.10.10.30.20.10.5
Bone: cortical thickness0.20.30.50.20.70.6
Bone: cortical thickness0.70.81.00.81.00.9
Bone: cortical tissue density6.28.09.62.93.12.4
Bone: elastic displacement0.20.30.40.60.60.2
Bone: elastic work0.10.10.30.10.0-0.6
Bone: endosteal estimation0.20.40.9-0.2-0.6-1.0
Bone: endosteal perimeter0.00.10.2-0.2-0.2-0.4
Bone: final force0.10.20.40.60.40.0
Bone: final moment0.20.30.50.70.60.2
Bone: marrow area0.20.40.9-0.1-0.5-1.0
Bone: maximum diameter0.20.40.5-0.7-0.4-0.7
Bone: maximum force0.10.20.20.50.50.2
Bone: maximum moment0.10.20.20.50.50.3
Bone: minimum diameter0.81.51.61.31.31.1
Bone: periosteal estimation0.00.10.10.20.1-0.4
Bone: periosteal perimeter0.00.00.0-0.2-0.0-0.2
Bone: post-yield work2.33.23.41.81.71.9
Bone: stiffness1.42.22.31.51.51.4
Bone: tissue strength0.10.10.3-0.2-0.2-0.6
Bone: trabecular number0.30.40.60.60.60.8
Bone: trabecular spacing0.10.10.1-0.3-0.3-0.3
Bone: trabecular thickness0.00.00.10.20.30.2
Bone: trabecular tissue density0.00.00.1-0.20.1-0.3
Breakpoint value in progressive ratio session0.20.20.3-0.6-0.4-0.3
Distance traveled before self-admin0.70.71.2-0.7-0.7-1.1
Distance traveled after self-admin0.40.40.50.70.70.5
Delta time in closed arm before/after self-admin0.00.00.10.20.10.3
Delta time in open arm before/after self-admin0.40.40.60.40.60.8
Diff in mean of infusions in LGA sessions0.10.10.1-0.3-0.00.3
Extinction: sum of active levers before priming0.10.10.1-0.3-0.3-0.3
Active lever presses in extinction session 62.01.92.21.51.31.3
Delta distance traveled before/after self-admin0.50.50.90.60.70.9
Delta ambulatory time before/after self-admin1.61.72.01.21.31.4
Time in closed arm before self-admin5.25.97.5-2.2-2.3-2.7
Time in closed arm after self-admin2.32.33.9-1.0-1.5-2.0
Time in open arm before self-admin6.97.37.72.82.72.6
Time in open arm after self-admin5.76.28.72.02.43.0
Sum of active levers in priming session hrs 5-60.70.70.8-0.9-0.8-0.8
Time to tail flick, vehicle, before self-admin1.01.01.70.71.01.3
Time to tail flick, vehicle, after self-admin0.20.20.70.20.20.8
Time to tail flick, test, before self-admin0.00.00.0-0.10.1-0.2
Time to tail flick, test, after self-admin2.72.83.91.41.62.0
Delta time to tail flick, vehicle, before/after SA0.00.00.10.10.10.3
Delta time to tail flick, test, before/after SA2.82.53.61.31.41.9
Ambulatory time before self-admin1.11.11.7-0.9-0.9-1.3
Ambulatory time after self-admin0.00.00.1-0.2-0.1-0.3
Total heroin consumption0.70.81.30.60.91.1
Area under the delay curve0.30.30.7-0.3-0.4-0.9
Delay disc. indifference point, 0s delay0.30.30.40.40.50.6
Delay disc. indifference point, 16s delay0.40.40.9-0.3-0.5-1.0
Delay disc. indifference point, 2s delay1.31.52.9-0.8-0.9-1.7
Delay disc. indifference point, 24s delay0.60.50.9-0.6-0.6-0.9
Delay disc. indifference point, 4s delay0.10.10.30.60.3-0.2
Delay disc. indifference point, 8s delay0.10.10.2-0.2-0.3-0.4
Delay discount exponential model param0.20.20.50.10.30.7
Delay discount hyperbolic model param0.30.30.80.30.40.9
Fecal boli incidents, locomotor time 11.81.92.4-1.5-1.5-1.0
Change in fecal boli incidents, locomotor task2.92.73.11.71.51.7
Time >=10cm from walls, locomotor time 10.40.41.0-0.2-0.01.0
Bouts of movement, locomotor time 12.02.33.0-1.7-1.4-1.3
Total resting periods, locomotor time 12.02.22.9-1.7-1.4-1.3
Rest time, locomotor task time 10.20.20.4-0.3-0.1-0.6
Distance moved, locomotor task time 10.20.30.5-0.1-0.5-0.7
Vertical activity count, locomotor time 10.20.20.40.60.5-0.1
Time >=10cm from walls, locomotor time 20.70.81.40.50.81.2
Bouts of movement, locomotor time 21.01.11.61.31.20.5
Total resting periods, locomotor time 20.80.81.31.11.00.3
Rest time, locomotor task time 20.10.10.10.30.3-0.1
Distance moved, locomotor task time 20.30.30.4-0.5-0.5-0.6
Vertical activity count, locomotor time 20.10.10.10.30.40.1
Weight adjusted by age0.30.40.50.60.50.7
Seeking ratio, delayed vs. immediate footshock0.30.40.60.40.60.8
Locomotion in novel chamber5.77.08.32.92.82.3
Locomotion in novel chamber post-restriction0.00.00.00.1-0.2-0.1
Progressive ratio0.30.30.50.70.2-0.7
Food seeking constrained by brief footshock0.30.40.70.70.80.2
Seeking ratio, punishment vs. effort0.20.20.6-0.10.40.8
Run reversals in cocaine runway, females1.81.82.4-1.1-1.3-1.6
Run reversals in cocaine runway, males0.10.10.20.40.4-0.1
Latency to leave start box in cocaine runway0.50.61.0-0.6-0.6-1.0
Latency to leave start box in cocaine runway, F0.60.60.8-0.8-0.7-0.9
Latency to leave start box in cocaine runway, M0.40.40.7-0.5-0.5-0.8
Cd content in liver2.22.43.11.81.41.5
Co content in liver1.61.82.01.41.31.4
Cu content in liver2.22.73.2-1.5-1.6-1.8
Fe content in liver0.70.81.2-0.8-0.8-1.1
K content in liver0.20.20.40.20.40.7
Mg content in liver0.10.10.10.40.40.3
Mn content in liver0.50.60.70.90.60.7
Na content in liver0.40.50.7-0.9-0.6-0.5
Rb content in liver1.01.21.41.21.20.9
Se content in liver0.00.00.1-0.3-0.2-0.0
Sr content in liver0.30.30.50.70.50.3
Zn content in liver0.00.00.10.20.30.0