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chr2:225,972,996-228,461,478

Best TWAS P=8.287547e-10 · Best GWAS P=1.236782e-12 conditioned to NaN

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Rap1gds1	gene expression	ENSRNOG00000015987	0.28	0.24	enet	236	0.26	1.5e-28	6.1	6.0	2.0e-09	0.57	0.80	0.20	FALSE
2	Adipose	Adh7	gene expression	ENSRNOG00000032959	0.53	0.37	enet	317	0.39	1.9e-45	4.6	5.2	2.0e-07	0.64	0.67	0.33	TRUE
3	Adipose	Rap1gds1	mRNA stability	ENSRNOG00000015987	0.13	0.06	blup	2505	0.10	1.3e-11	2.4	5.5	3.9e-08	0.54	0.79	0.21	TRUE
4	BLA	Metap1	gene expression	ENSRNOG00000012947	0.08	0.03	top1	1	0.03	9.1e-03	-5.5	-5.5	4.2e-08	-0.62	0.14	0.04	TRUE
5	BLA	Eif4e	gene expression	ENSRNOG00000052343	0.11	0.04	lasso	6	0.04	2.9e-03	-5.9	5.2	2.3e-07	0.57	0.56	0.24	TRUE
6	Brain	Tspan5	gene expression	ENSRNOG00000015913	0.42	0.23	enet	56	0.31	2.0e-29	-5.5	5.4	8.7e-08	0.77	0.84	0.16	FALSE
7	Brain	Rap1gds1	gene expression	ENSRNOG00000015987	0.43	0.47	enet	237	0.52	7.2e-56	-6.7	5.9	4.0e-09	0.59	0.17	0.83	FALSE
8	Brain	Trmt10a	mRNA stability	ENSRNOG00000011025	0.08	0.01	enet	27	0.04	7.2e-05	-4.7	-5.1	3.0e-07	-0.19	0.56	0.42	FALSE
9	Eye	Rap1gds1	gene expression	ENSRNOG00000015987	0.43	0.23	top1	1	0.23	2.2e-04	-6.1	6.1	1.0e-09	0.71	0.14	0.06	FALSE
10	LHb	Tspan5	gene expression	ENSRNOG00000015913	0.26	0.10	enet	51	0.17	9.9e-05	-5.9	5.8	7.7e-09	0.65	0.68	0.17	FALSE
11	LHb	Stpg2	gene expression	ENSRNOG00000023457	0.20	0.11	blup	2587	0.11	1.6e-03	-6.1	5.8	7.6e-09	0.62	0.51	0.28	FALSE
12	Liver	Rap1gds1	gene expression	ENSRNOG00000015987	0.25	0.23	top1	1	0.23	3.8e-25	6.1	6.1	8.3e-10	0.72	0.78	0.22	TRUE
13	NAcc	Rap1gds1	mRNA stability	ENSRNOG00000015987	0.22	0.16	top1	1	0.16	2.5e-04	-6.1	6.1	1.0e-09	0.67	0.13	0.05	FALSE
14	NAcc2	Rap1gds1	gene expression	ENSRNOG00000015987	0.09	0.06	enet	2	0.07	1.2e-04	-5.9	5.3	1.0e-07	0.02	0.59	0.32	TRUE
15	OFC	Tspan5	gene expression	ENSRNOG00000015913	0.40	0.08	blup	3183	0.10	2.7e-03	-6.0	5.3	1.3e-07	0.65	0.53	0.43	FALSE
16	OFC	Tspan5	isoform ratio	ENSRNOT00000021381	0.23	0.09	lasso	2	0.21	1.1e-05	-6.1	-6.0	1.6e-09	-0.76	0.36	0.41	FALSE
17	PL2	Rap1gds1	gene expression	ENSRNOG00000015987	0.41	0.24	top1	1	0.24	3.7e-13	-5.4	5.4	6.2e-08	0.81	1.00	0.00	FALSE
18	PL2	Tspan5	isoform ratio	ENSRNOT00000021381	0.31	0.26	top1	1	0.26	3.6e-14	5.7	-5.7	1.6e-08	-0.77	0.86	0.14	TRUE
19	PL2	Tspan5	isoform ratio	ENSRNOT00000111381	0.25	0.20	top1	1	0.20	2.5e-11	5.6	5.6	1.9e-08	0.78	0.88	0.12	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.