Hub : Genes

Inpp5k

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000056954	0.34	0.17	1.6e-15	0.13	0.12	0.12	0.13	2.6e-14	2.0e-13	5.4e-13	2.6e-14
2	Adipose	mRNA stability	ENSRNOG00000056954	0.05	0.04	8.2e-04	0	0.01	0.01	0.01	2.8e-01	6.8e-03	1.1e-02	5.4e-02
3	BLA	gene expression	ENSRNOG00000056954	0.25	0.1	1.7e-12	0.22	0.2	0.21	0.21	3.5e-12	7.7e-11	2.0e-11	1.1e-11
4	Brain	gene expression	ENSRNOG00000056954	0.08	0.06	1.3e-06	0.05	0.08	0.07	0.06	2.4e-05	9.4e-08	4.1e-07	2.5e-06
5	IL	gene expression	ENSRNOG00000056954	0.21	0.16	1.5e-03	0.11	0.11	0.12	0.11	1.4e-03	1.6e-03	7.3e-04	1.2e-03
6	PL	gene expression	ENSRNOG00000056954	0.12	0.07	2.5e-08	0.08	0.09	0.07	0.07	5.7e-07	4.7e-07	1.0e-05	2.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	0.5	1.6	4.5	-1.4	-0.3	2.1	0.7	1.2	1.2
BMI without tail	0.3	0.6	1.2	0.2	0.7	0.5	0.9	1.1	1.0
Body weight	1.6	6.7	10.5	0.8	2.4	1.6	3.2	3.2	3.2
Epididymis fat weight	2.4	5.5	9.2	-0.6	1.3	2.6	2.6	2.9	3.0
Glucose	1.7	2.6	5.2	1.0	-0.3	-2.3	-1.4	-1.9	-2.0
Heart weight	0.3	0.4	0.7	0.4	0.7	0.1	0.8	0.7	0.7
Left kidney weight	1.8	5.3	12.6	3.6	2.4	-3.6	0.8	-0.1	-0.5
Right kidney weight	1.7	5.0	11.9	3.5	2.5	-3.2	1.1	0.2	-0.1
Tail length	3.8	11.4	18.5	3.6	4.3	-1.1	3.9	3.3	3.1
Length with tail	2.0	7.4	11.3	2.5	3.4	-0.4	3.3	2.7	2.8
Length without tail	1.0	2.3	3.8	0.2	1.3	1.1	2.0	1.8	1.9
Liver weight, left	2.0	3.2	5.1	2.2	2.2	-0.8	1.9	1.6	1.5
Liver weight, right	1.2	2.0	2.9	1.4	1.7	-0.1	1.6	1.5	1.5
Parametrial fat weight	6.5	12.7	21.2	0.1	2.6	3.2	4.2	4.5	4.6
Retroperitoneal fat weight	0.0	0.0	0.1	0.3	0.3	-0.1	0.3	0.1	0.1
Intraocular pressure	1.7	2.5	3.9	-2.0	-2.0	0.7	-1.6	-1.5	-1.2
Extensor digitorum longus weight	2.5	10.1	30.1	-4.3	-1.6	5.5	0.9	1.9	2.3
Soleus weight	3.0	8.7	14.4	0.0	2.2	2.6	3.5	3.7	3.8
Tibialis anterior weight	4.1	14.0	39.4	-3.9	-0.7	6.3	2.1	3.3	3.7
Tibia length	1.4	3.9	7.9	2.8	2.5	-1.6	1.8	1.5	1.2
Number of licking bursts	0.2	0.2	0.4	0.1	-0.0	-0.6	-0.3	-0.6	-0.6
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.2	0.1	0.5	0.3	0.5	0.5
Times rat made contact with spout	1.0	1.1	2.9	1.7	1.2	-1.5	0.5	0.3	-0.0
Mean time between licks in bursts	0.7	1.0	1.6	0.9	1.3	-0.2	1.2	1.0	0.9
Mean num. licks in bursts	0.5	0.6	1.3	1.1	0.9	-0.5	0.6	0.8	0.6
Std. dev. time between licks in bursts	0.2	0.2	0.8	-0.7	-0.2	0.9	0.1	0.3	0.3
Water consumed over 24 hours	1.0	1.2	2.1	1.5	1.4	-0.9	1.0	0.8	0.7
Indifference point 0 sec	0.1	0.1	0.3	-0.5	-0.2	0.6	0.1	0.3	0.2
Indifference point AUC	0.8	1.0	1.4	-0.9	-1.1	-0.0	-1.2	-1.2	-1.0
Indifference point function ln k	0.4	0.5	1.0	-0.3	0.2	1.0	0.6	0.9	0.9
Indifference point function log k	0.4	0.5	1.0	-0.3	0.2	1.0	0.6	0.9	0.9
Delay discounting total patch changes 0 sec	0.1	0.2	0.4	-0.6	-0.4	0.6	-0.1	0.2	0.1
Delay discounting total patch changes 12 sec	0.2	0.3	0.8	0.6	0.1	-0.9	-0.3	-0.5	-0.6
Delay discounting total patch changes 18 sec	0.4	0.5	1.5	0.8	0.4	-1.2	-0.1	-0.5	-0.5
Delay discounting total patch changes 24 sec	0.5	0.6	1.0	0.2	-0.3	-0.9	-0.8	-0.9	-1.0
Delay discounting total patch changes 6 sec	0.5	0.7	1.0	-0.8	-1.0	-0.1	-1.0	-1.0	-0.9
Delay discounting time to switch 0 sec	1.2	1.8	4.4	2.1	1.6	-1.8	0.9	0.3	0.2
Delay discounting water rate 0 sec	0.7	1.1	2.3	-1.5	-1.3	1.1	-0.9	-0.6	-0.5
Delay discounting water rate 12 sec	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.0	0.1
Delay discounting water rate 18 sec	1.3	1.8	5.0	-1.5	-0.4	2.2	0.7	1.0	1.2
Delay discounting water rate 24 sec	0.3	0.3	0.9	-0.9	-0.7	0.7	-0.4	-0.2	-0.2
Delay discounting water rate 6 sec	0.4	0.6	0.9	-0.5	-0.9	-0.2	-1.0	-0.9	-0.9
Locomotor activity	0.0	0.1	0.1	0.2	0.2	0.4	0.3	-0.1	0.3
Locomotor testing distance	0.0	0.0	0.1	0.0	0.0	0.3	0.2	-0.1	0.1
Locomotor testing rearing	0.3	0.4	1.0	-1.0	-0.7	1.0	-0.2	-0.3	-0.1
Light reinforcement 1	0.0	0.0	0.1	-0.3	-0.0	0.3	0.2	-0.1	0.0
Light reinforcement 2	1.1	1.4	4.4	1.6	0.7	-2.1	-0.1	-0.7	-0.8
Reaction time number correct	0.1	0.1	0.2	0.1	0.3	0.1	0.4	0.4	0.3
Reaction time mean minus median	0.5	0.6	1.0	-0.8	-1.0	0.2	-0.9	-0.8	-0.7
Reaction time mean minus median AUC	0.9	1.2	3.0	-1.7	-1.3	1.4	-0.6	-0.3	-0.2
Reaction time num false alarms	1.4	2.0	3.3	-1.8	-1.8	1.0	-1.3	-1.2	-1.0
Reaction time num false alarms AUC	1.3	1.9	3.1	-1.7	-1.8	0.9	-1.4	-1.2	-1.1
Reaction time trials correct on left	0.1	0.1	0.2	0.1	0.3	0.1	0.4	0.4	0.3
Reaction time trials on left	0.1	0.1	0.2	-0.0	0.2	0.2	0.3	0.4	0.3
Reaction time mean	0.1	0.1	0.2	0.1	-0.3	-0.3	-0.5	-0.4	-0.4
Reaction time mean AUC	0.4	0.5	0.8	-0.1	-0.7	-0.4	-0.9	-0.8	-0.8
Median of all reaction times	0.1	0.2	0.4	0.5	-0.0	-0.6	-0.3	-0.4	-0.4
Reaction time omissions	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.0	-0.1
Reaction time false alarm rate	1.1	1.6	2.7	-1.6	-1.6	0.8	-1.3	-1.1	-1.0
Reaction time premature initiation rate	0.2	0.3	1.0	-0.7	-0.4	1.0	0.0	0.4	0.4
Reaction time premature initiations	0.3	0.4	1.2	-0.8	-0.3	1.1	0.2	0.5	0.5
Std. dev. reaction times	0.4	0.6	1.1	-0.8	-1.0	0.3	-1.0	-0.7	-0.7
Reaction time trials completed	0.1	0.1	0.2	-0.0	0.2	0.2	0.3	0.4	0.3
Reaction time trials AUC	0.0	0.1	0.2	-0.0	0.2	0.2	0.3	0.4	0.3
Social response proportion	3.3	3.6	6.0	1.2	2.0	0.6	2.2	2.4	2.3
Social responses	1.6	2.0	3.3	0.2	1.2	1.1	1.7	1.8	1.8
Social time	2.0	2.6	4.3	-0.2	0.9	1.7	1.8	2.1	2.1
Conditioned locomotion	0.6	0.7	1.1	-0.3	-0.8	-0.5	-1.1	-1.0	-1.0
Cocaine response after cond. corrected	0.3	0.4	0.5	0.6	0.7	-0.1	0.6	0.7	0.7
Cocaine response after cond. not corrected	0.7	0.7	1.2	0.5	0.9	0.2	1.0	1.1	1.0
Cocaine response before conditioning	0.6	0.8	1.3	-0.5	0.3	1.1	0.9	1.1	1.0
Saline control response	0.3	0.4	1.1	-1.0	-0.3	1.1	0.2	0.3	0.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.7	-0.1	0.7	0.3	0.5	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.4	0.5	-0.5	0.3	0.4	0.2
Condit. Reinf. active responses	0.6	0.9	2.5	-1.6	-0.7	1.5	0.0	0.3	0.3
Condit. Reinf. inactive responses	2.1	2.6	7.1	-2.7	-1.7	2.3	-0.6	-0.3	-0.1
Condit. Reinf. lever presses	0.8	1.1	1.6	-1.3	-1.2	0.1	-1.1	-1.1	-1.1
Condit. Reinf. lever reinforcers received	0.7	0.9	2.8	-1.7	-0.8	1.4	-0.1	0.2	0.1
Pavlov. Cond. lever latency	0.8	1.1	1.9	-0.1	0.5	1.1	1.0	1.4	1.4
Pavlov. Cond. magazine entry latency	0.7	0.8	2.0	1.3	0.9	-1.4	0.3	-0.1	-0.3
Pavlov. Cond. change in total contacts	0.3	0.5	1.4	0.5	0.1	-1.2	-0.4	-0.6	-0.8
Pavlov. Cond. index score	0.8	1.1	1.9	0.3	-0.3	-1.4	-0.8	-1.3	-1.3
Pavlov. Cond. latency score	1.0	1.3	2.3	0.2	-0.4	-1.4	-1.0	-1.5	-1.5
Pavlov. Cond. lever contacts	0.4	0.5	1.2	0.5	0.0	-1.1	-0.4	-0.8	-0.8
Pavlov. Cond. magazine entry number	0.6	0.7	2.2	-1.1	-0.6	1.5	0.0	0.5	0.6
Pavlov. Cond. intertrial magazine entries	1.0	1.3	3.8	-1.5	-0.5	1.9	0.4	0.7	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.7	0.3	-0.3	-1.3	-0.8	-1.2	-1.3
Pavlov. Cond. response bias	0.5	0.7	2.0	0.8	0.2	-1.4	-0.3	-0.8	-0.9
Conditioned reinforcement - actives	1.2	1.2	3.3	-1.6	-0.9	1.8	-0.1	0.4	0.5
Conditioned reinforcement - inactives	0.5	0.6	1.5	-1.2	-0.8	1.1	-0.3	0.0	0.1
Conditioned locomotion	0.2	0.2	0.4	-0.3	-0.5	-0.1	-0.5	-0.6	-0.6
Intermittent access intake day 1-15 change	2.2	2.1	3.5	-1.8	-1.9	0.5	-1.6	-1.3	-1.3
Intermittent access intake escalation	2.1	2.1	2.9	-1.2	-1.6	-0.2	-1.7	-1.6	-1.6
Intermittent access intake escalation 2	2.2	2.2	3.4	-0.9	-1.5	-0.7	-1.8	-1.9	-1.8
Intermitt. access day 1 inactive lever presses	1.6	1.7	2.9	0.4	-0.5	-1.7	-1.3	-1.5	-1.7
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.9	-0.3	-0.9	-0.6	-1.1	-1.4	-1.2
Intermitt. access escalation Index	6.2	5.6	8.2	2.3	2.9	-0.3	2.8	2.4	2.4
Intermittent access day 1 total infusions	0.3	0.3	1.0	-0.7	-0.1	1.0	0.3	0.4	0.5
Intermittent access day 15 total infusions	1.4	1.6	3.6	-1.9	-1.6	1.2	-1.0	-0.8	-0.6
Intermittent access terminal intake (last 3 days)	0.8	0.9	2.4	-1.5	-0.8	1.6	-0.0	0.2	0.4
Intermittent access total infusions	0.6	0.7	1.6	-1.3	-1.0	0.9	-0.6	-0.4	-0.2
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	0.4	-0.6	0.1	-0.1	-0.2
Intermittent access day 15 total locomotion	0.6	0.6	1.0	-0.6	-0.8	-0.2	-0.9	-1.0	-0.9
Intermittent access total locomotion	0.1	0.1	0.1	-0.2	-0.3	-0.1	-0.3	-0.3	-0.3
Intermittent access standard deviation	4.6	4.9	7.6	-2.4	-2.8	0.4	-2.6	-2.3	-2.1
Cocaine induced anxiety	1.0	1.1	1.8	-1.2	-1.3	0.4	-1.2	-1.1	-0.9
Post-drug Anxiety	0.2	0.3	0.6	-0.8	-0.6	0.6	-0.4	-0.3	-0.1
Baseline Anxiety	0.2	0.2	0.4	0.5	0.6	-0.2	0.6	0.5	0.5
Lifetime Intake	0.7	0.8	1.9	-1.4	-1.1	0.9	-0.7	-0.6	-0.4
Incentive Sensitization - Responses	0.3	0.3	0.8	-0.9	-0.7	0.5	-0.5	-0.2	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.7	-0.6	0.3	-0.4	-0.3	-0.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.4	-0.1	0.6	0.2	0.3	0.4
Progressive ratio test 1 breakpoint	0.4	0.4	1.0	-0.5	-0.0	1.0	0.4	0.6	0.7
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.0	-0.3	-0.7	-0.5	-1.0	-0.8	-1.0
Progressive ratio test 2 active lever presses	0.5	0.5	1.2	-1.1	-0.9	0.8	-0.5	-0.3	-0.2
Progressive ratio test 2 breakpoint	0.5	0.6	1.4	-1.2	-1.0	0.7	-0.6	-0.4	-0.3
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.5	-1.2	-1.2	0.4	-1.1	-0.9	-0.8
Total sessions with >9 infusions	0.0	0.0	0.2	-0.2	-0.1	0.4	0.0	0.1	0.2
Short access day 1 total inactive lever presses	0.1	0.2	0.3	-0.1	0.2	0.4	0.4	0.6	0.5
Short access day 10 total inactive lever presses	0.3	0.3	0.8	0.9	0.6	-0.7	0.2	0.3	0.0
Short access day 1 total infusions	1.6	1.7	2.6	-1.3	-1.6	0.3	-1.5	-1.3	-1.2
Short access day 10 total infusions	0.7	0.7	1.9	-1.4	-1.0	1.2	-0.4	-0.2	-0.0
Short access total infusions	1.1	1.2	2.2	-1.5	-1.4	0.8	-1.1	-0.9	-0.7
Short access day 1 locomotion	0.5	0.6	0.9	-0.5	-0.9	-0.1	-1.0	-0.9	-0.9
Short access day 10 total locomotion	0.3	0.4	0.7	0.2	-0.3	-0.7	-0.7	-0.6	-0.8
Short access total locomotion	0.5	0.5	0.8	-0.5	-0.8	-0.2	-0.9	-0.8	-0.9
Compulsive drug intake	0.8	0.8	1.4	1.2	1.1	-0.4	0.9	0.8	0.7
One hour access (0.3 mA shock)	1.2	1.4	3.4	-1.8	-1.3	1.6	-0.6	-0.3	-0.1
One hour access (shock baseline)	1.2	1.4	3.4	-1.8	-1.4	1.3	-0.8	-0.6	-0.4
Number of responses in last shaping day	0.9	0.9	1.5	-0.1	-0.8	-0.8	-1.2	-1.2	-1.2
Context. condit. distance diff. score	0.7	0.8	1.6	-0.3	0.3	1.2	0.8	1.1	1.2
Locomotion velocity, session 1	2.6	2.8	4.8	-0.0	1.1	1.6	1.9	2.2	2.2
Locomotion distance, session 1	0.4	0.5	1.3	-0.8	-0.2	1.2	0.4	0.5	0.6
Locomotion velocity, session 2	0.4	0.5	1.0	-0.5	0.2	1.0	0.6	0.8	0.8
Locomotion distance, session 2	0.8	1.2	3.2	-1.2	-0.2	1.8	0.6	0.9	1.0
Locomotion velocity, session 3	2.0	2.3	6.8	1.6	0.4	-2.6	-0.7	-1.2	-1.5
Locomotion distance, session 3	0.2	0.2	0.3	-0.5	-0.5	0.2	-0.5	-0.3	-0.4
Stereotopy head waving bouts, day 3	0.4	0.4	0.7	0.6	0.9	-0.5	0.8	0.6	0.5
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.2	-0.2	-0.6	-0.3	-0.5	-0.6
Locomotion velocity, session 7	0.5	0.6	1.7	-1.0	-0.5	1.3	-0.0	0.5	0.4
Locomotion distance, session 7	0.8	1.0	2.9	-1.2	-0.5	1.7	0.2	0.7	0.8
Stereotopy head waving bouts, day 7	0.6	0.7	1.0	-0.5	0.4	1.0	0.9	1.0	0.9
Stereotopy head waving duration, day 7	0.8	1.0	1.5	-0.7	0.4	1.2	1.1	1.2	1.1
Locomotion velocity, session 8	0.2	0.3	0.9	-0.8	-0.3	1.0	0.1	0.2	0.3
Locomotion distance, session 8	1.5	2.2	3.5	-0.4	0.7	1.9	1.6	1.8	1.9
Degree of sensitization distance	0.8	0.8	1.5	-0.0	0.5	1.0	0.9	1.1	1.2
Degree of sensitization stereotypy	1.0	1.1	1.8	-0.2	0.7	1.1	1.2	1.3	1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.7	0.6	-0.6	0.3	0.3	0.1
Condit. Reinf. active-inactive response ratio	1.8	1.9	4.8	2.2	1.6	-2.0	0.7	0.3	0.0
Condit. Reinf. active responses	0.1	0.2	0.3	-0.6	-0.2	0.6	0.1	0.4	0.3
Condit. Reinf. inactive responses	2.7	3.2	8.1	-2.9	-2.0	2.5	-0.8	-0.3	0.0
Incentive salience index mean	0.4	0.4	0.7	0.8	0.8	-0.5	0.6	0.7	0.4
Condit. Reinf. lever presses	1.1	1.5	2.9	0.9	1.3	0.2	1.3	1.7	1.4
Time in familiar zone, hab. session 1	1.6	1.5	3.1	-1.8	-1.5	1.4	-1.0	-0.6	-0.4
Time in novel zone, hab. session 1	1.2	1.2	2.6	1.6	1.4	-1.3	0.8	0.4	0.2
Total zone transitions, hab. session 1	1.4	1.9	5.1	-2.3	-1.3	2.1	-0.2	-0.1	0.2
Total locomotion distance, hab. session 1	0.4	0.5	1.7	-1.1	-0.4	1.3	0.2	0.1	0.4
Locomotion velocity, hab. session 1	0.5	0.7	2.1	-1.2	-0.6	1.4	0.0	0.0	0.3
Time in familiar zone, hab. session 2	1.0	1.0	3.2	-1.5	-0.7	1.8	0.1	0.3	0.5
Time in novel zone, hab. session 2	2.3	2.3	7.1	2.1	1.0	-2.7	-0.2	-0.6	-0.9
Total zone transitions, hab. session 2	0.6	0.7	1.9	-0.9	0.0	1.4	0.7	0.7	0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.0	0.3	0.4	0.6	0.4	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.0	0.3	0.3	0.4	0.3	0.4
Novel to familiar place preference ratio	0.5	0.5	0.9	-0.5	-0.9	0.0	-0.9	-0.8	-0.8
Novelty place preference	0.1	0.1	0.2	-0.1	-0.4	0.0	-0.5	-0.4	-0.4
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2	-0.1	-0.1
Total zone transitions, NPP test	0.7	1.0	2.6	-1.6	-0.7	1.6	0.2	0.2	0.4
Total locomotion distance, NPP test	0.4	0.6	1.5	-1.2	-0.9	0.9	-0.4	-0.5	-0.3
Locomotion velocity, NPP test	0.7	0.9	1.5	-1.2	-1.2	0.5	-0.9	-1.0	-0.8
Pavlov. Cond. lever latency	0.5	0.6	1.2	-1.1	-1.0	0.8	-0.6	-0.7	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	1.6	0.8	1.0	0.2	1.0	1.3	1.1
Pavlov. Cond. change in total contacts	0.3	0.3	1.1	0.6	0.2	-1.0	-0.2	-0.3	-0.4
Pavlov. Cond. index score	0.9	1.2	1.7	1.1	1.3	-0.1	1.1	1.3	1.1
Pavlov. Cond. latency score	1.3	1.7	2.5	1.4	1.6	-0.4	1.4	1.5	1.2
Pavlov. Cond. lever contacts	0.5	0.6	1.0	1.0	1.0	-0.6	0.7	0.7	0.5
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.3	-0.5	-0.1	-0.5	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.9	-1.7	-1.2	0.8	-0.7	-0.8	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	0.8	1.0	0.0	0.9	1.2	0.9
Pavlov. Cond. response bias	0.4	0.5	0.8	0.6	0.7	0.1	0.7	0.9	0.8
Bone: apparent density	2.0	3.3	8.1	-1.3	0.1	2.9	1.4	1.9	2.1
Bone surface	1.7	2.9	8.2	-1.8	-0.3	2.9	1.0	1.5	1.7
Bone volume	1.8	3.0	8.6	-1.9	-0.3	2.9	1.0	1.5	1.7
Bone: connectivity density	2.8	4.3	11.7	-1.9	-0.2	3.4	1.4	2.0	2.2
Bone: cortical apparent density	0.7	0.9	1.4	-0.7	-1.1	-0.3	-1.2	-1.2	-1.0
Bone: cortical area	0.9	1.4	3.4	0.8	-0.2	-1.8	-1.0	-1.2	-1.4
Bone: cortical porosity	0.1	0.1	0.2	-0.0	0.2	0.4	0.4	0.3	0.4
Bone: cortical porosity	0.0	0.0	0.1	0.2	0.3	0.0	0.2	0.1	0.2
Bone: cortical thickness	2.5	4.1	12.5	2.2	0.5	-3.5	-1.0	-1.5	-1.9
Bone: cortical thickness	0.8	1.0	2.4	1.6	1.0	-1.5	0.3	-0.0	-0.1
Bone: cortical tissue density	0.6	0.7	1.1	-0.7	-1.0	-0.1	-1.1	-1.0	-0.9
Bone: elastic displacement	0.6	0.7	1.3	-0.4	-0.8	-0.3	-1.0	-1.1	-1.0
Bone: elastic work	1.9	2.4	6.7	1.6	0.3	-2.6	-0.9	-1.3	-1.6
Bone: endosteal estimation	0.1	0.2	0.5	-0.7	-0.5	0.6	-0.2	-0.2	-0.1
Bone: endosteal perimeter	0.7	1.4	3.7	-1.9	-1.3	1.6	-0.6	-0.3	-0.1
Bone: final force	0.9	1.4	3.1	1.7	1.4	-1.5	0.8	0.6	0.2
Bone: final moment	0.6	1.0	2.2	1.5	1.1	-1.4	0.6	0.4	0.1
Bone: marrow area	0.1	0.2	0.5	-0.7	-0.4	0.5	-0.2	-0.2	-0.1
Bone: maximum diameter	0.5	1.0	1.6	-1.2	-1.3	0.3	-1.2	-0.8	-0.9
Bone: maximum force	0.6	1.1	2.5	1.6	1.1	-1.6	0.4	0.1	-0.1
Bone: maximum moment	0.4	0.7	2.0	1.3	0.8	-1.4	0.2	-0.1	-0.3
Bone: minimum diameter	0.4	0.8	2.3	1.3	0.7	-1.5	0.1	-0.4	-0.4
Bone: periosteal estimation	0.2	0.3	0.8	0.3	-0.1	-0.9	-0.5	-0.7	-0.7
Bone: periosteal perimeter	0.3	0.5	0.8	-0.6	-0.9	-0.1	-0.9	-0.8	-0.8
Bone: post-yield work	0.4	0.5	0.8	0.3	0.7	0.3	0.9	0.8	0.9
Bone: stiffness	1.1	1.8	2.9	0.7	1.4	0.5	1.6	1.7	1.6
Bone: tissue strength	1.0	1.0	3.1	1.3	0.5	-1.8	-0.3	-0.6	-0.8
Bone: trabecular number	2.0	3.2	8.7	-1.6	-0.1	2.9	1.2	1.6	1.9
Bone: trabecular spacing	0.4	0.5	1.1	0.4	-0.1	-1.0	-0.6	-0.6	-0.9
Bone: trabecular thickness	0.1	0.2	0.5	-0.4	-0.0	0.7	0.3	0.4	0.4
Bone: trabecular tissue density	1.3	1.8	4.0	0.8	-0.3	-2.0	-1.2	-1.5	-1.6
Breakpoint value in progressive ratio session	1.5	1.7	2.6	0.6	1.3	0.6	1.6	1.6	1.6
Distance traveled before self-admin	1.0	1.1	1.9	0.5	-0.3	-1.4	-0.9	-1.3	-1.3
Distance traveled after self-admin	0.1	0.1	0.3	0.5	0.4	-0.4	0.2	0.2	0.1
Delta time in closed arm before/after self-admin	0.5	0.5	0.8	-0.5	-0.8	-0.2	-0.8	-0.9	-0.8
Delta time in open arm before/after self-admin	1.1	1.0	1.7	0.2	0.9	0.7	1.2	1.3	1.3
Diff in mean of infusions in LGA sessions	1.1	1.2	1.9	0.9	1.3	0.0	1.2	1.4	1.2
Extinction: sum of active levers before priming	0.9	1.0	2.2	-0.7	0.1	1.5	0.7	1.1	1.1
Active lever presses in extinction session 6	0.7	0.7	1.4	-0.6	0.1	1.2	0.6	1.1	0.9
Delta distance traveled before/after self-admin	1.5	1.6	3.1	0.2	1.0	1.0	1.4	1.8	1.6
Delta ambulatory time before/after self-admin	1.1	1.2	2.4	0.2	0.8	0.9	1.2	1.5	1.4
Time in closed arm before self-admin	2.0	2.3	3.8	0.2	1.3	1.2	1.8	1.9	2.0
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.0	-0.3	-0.1	-0.2	-0.2
Time in open arm before self-admin	3.5	3.8	6.1	0.9	-0.8	-2.5	-2.0	-2.3	-2.4
Time in open arm after self-admin	0.6	0.7	1.1	0.4	-0.3	-1.1	-0.9	-0.8	-1.1
Sum of active levers in priming session hrs 5-6	2.0	2.0	3.6	0.3	1.2	1.1	1.6	1.9	1.8
Time to tail flick, vehicle, before self-admin	3.5	3.5	6.7	-1.0	0.5	2.6	1.7	2.2	2.3
Time to tail flick, vehicle, after self-admin	0.9	0.9	2.5	-1.6	-1.1	1.3	-0.4	-0.2	-0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.6	-0.5	-0.0	0.8	0.3	0.5	0.5
Time to tail flick, test, after self-admin	0.3	0.3	0.4	0.4	0.6	0.1	0.6	0.6	0.7
Delta time to tail flick, vehicle, before/after SA	1.8	1.7	2.6	-0.8	-1.4	-0.5	-1.6	-1.6	-1.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.3	-0.1	-0.1
Ambulatory time before self-admin	1.1	1.1	3.0	1.2	0.3	-1.7	-0.4	-1.0	-1.0
Ambulatory time after self-admin	1.6	1.7	2.8	1.6	1.7	-0.6	1.4	1.3	1.1
Total heroin consumption	2.8	3.4	6.1	0.0	1.3	1.7	2.0	2.5	2.4
Area under the delay curve	0.7	0.8	1.9	0.9	0.2	-1.4	-0.5	-0.8	-0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.3	0.1	0.3	0.3	0.1	0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	0.4	-0.1	-0.9	-0.5	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.6	0.6	1.4	0.8	0.1	-1.2	-0.4	-0.9	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.0	-0.5	-0.3	-0.3	-0.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.4	1.0	0.6	-1.2	0.0	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.3	0.4	1.1	0.7	0.3	-1.0	-0.2	-0.4	-0.5
Delay discount exponential model param	0.7	0.8	2.1	-1.1	-0.4	1.5	0.3	0.6	0.8
Delay discount hyperbolic model param	0.7	0.7	1.9	-1.0	-0.3	1.4	0.4	0.7	0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.1	0.3	0.2	0.4	0.4	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	0.8	0.6	-0.9	0.1	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.5	-0.5	0.5	-0.4	0.1	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.5	-0.2	0.3	-0.1	0.3	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.6	-0.4	0.3	-0.3	0.1	-0.0
Rest time, locomotor task time 1	0.5	0.5	0.9	-0.8	-1.0	0.1	-0.9	-0.7	-0.6
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	-0.2	0.3	-0.1	0.0	0.0
Vertical activity count, locomotor time 1	0.3	0.3	1.0	-0.8	-0.3	1.0	0.2	0.3	0.4
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.9	0.6	0.1	-0.9	-0.5	-0.3	-0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.5	0.2	-0.5	-0.0	-0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	0.1	0.1
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.5	-0.4	0.5	-0.1	-0.1	0.1
Distance moved, locomotor task time 2	0.6	0.6	0.8	-0.9	-0.9	-0.0	-0.9	-0.8	-0.9
Vertical activity count, locomotor time 2	0.2	0.2	0.5	0.2	-0.0	-0.7	-0.3	-0.5	-0.5
Weight adjusted by age	0.4	0.4	1.1	-0.7	-0.1	1.1	0.4	0.6	0.6
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.7	-0.2	-1.0	-0.9	-1.4	-1.6	-1.6
Locomotion in novel chamber	4.5	5.6	8.4	-1.7	-2.6	-0.5	-2.9	-2.8	-2.7
Locomotion in novel chamber post-restriction	0.3	0.3	0.7	-0.8	-0.7	0.5	-0.5	-0.3	-0.3
Progressive ratio	0.7	0.8	1.7	-1.3	-1.2	0.9	-0.8	-0.5	-0.5
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.1	-0.1	-0.3	-0.3	-0.4	-0.4
Seeking ratio, punishment vs. effort	0.6	0.7	1.8	1.3	0.9	-1.2	0.4	-0.0	-0.0
Run reversals in cocaine runway, females	1.0	1.0	1.5	-0.9	-1.2	0.1	-1.1	-1.2	-1.0
Run reversals in cocaine runway, males	0.8	0.8	1.4	-1.2	-1.2	0.6	-0.8	-0.7	-0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.5	0.4	-0.5	0.1	-0.0	-0.1
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	0.8	0.7	-0.5	0.5	0.3	0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.4	-0.2	0.3	0.4	0.2
Cd content in liver	0.4	0.5	1.5	-0.9	-0.3	1.2	0.3	0.2	0.6
Co content in liver	0.1	0.1	0.2	0.3	0.1	-0.5	-0.1	-0.3	-0.3
Cu content in liver	0.5	0.6	1.7	1.2	0.7	-1.3	0.1	-0.2	-0.3
Fe content in liver	0.8	0.9	1.6	1.1	1.2	-0.4	1.1	0.8	0.9
K content in liver	2.1	2.1	3.5	1.9	1.9	-1.1	1.4	1.3	0.9
Mg content in liver	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.3	-0.1	-0.3
Mn content in liver	0.1	0.2	0.5	-0.5	-0.2	0.7	0.1	0.4	0.3
Na content in liver	1.4	1.5	4.8	1.6	0.7	-2.2	-0.2	-0.6	-0.9
Rb content in liver	0.8	0.9	2.5	-1.5	-0.9	1.6	-0.2	0.2	0.3
Se content in liver	0.5	0.6	1.8	1.0	0.4	-1.3	-0.2	-0.5	-0.6
Sr content in liver	0.4	0.4	1.0	-0.7	-0.2	1.0	0.3	0.5	0.6
Zn content in liver	0.5	0.5	1.1	-1.1	-0.8	1.0	-0.4	-0.1	-0.1