Hub : Genes

Ext1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability ENSRNOG00000024886 0.38 0.13 0.0e+00 0.26 0.28 0.28 0.28 4.2e-14 1.2e-15 2.6e-15 2.6e-15
2 Brain gene expression ENSRNOG00000024886 0.09 0.07 4.9e-06 0.06 0.05 0.06 0.03 1.4e-06 1.6e-05 3.5e-06 4.4e-04
3 Brain mRNA stability ENSRNOG00000024886 0.1 0.06 3.2e-08 0.08 0.09 0.09 0.06 5.4e-08 6.9e-09 2.6e-08 7.9e-06
4 IL mRNA stability ENSRNOG00000024886 0.27 0.14 1.4e-04 0.16 0.12 0.11 0.15 1.1e-04 7.7e-04 1.3e-03 1.6e-04
5 Liver gene expression ENSRNOG00000024886 0.08 0.06 1.7e-08 0.05 0.04 0.04 0.05 4.9e-06 9.1e-05 1.4e-05 2.4e-06
6 OFC mRNA stability ENSRNOG00000024886 0.44 0.19 1.0e-05 0.1 0.17 0.1 0.09 2.6e-03 8.7e-05 2.0e-03 4.0e-03
7 PL gene expression ENSRNOG00000024886 0.03 0.03 9.3e-03 0.03 0.02 0.01 0.02 4.9e-03 1.5e-02 4.1e-02 8.7e-03
8 PL mRNA stability ENSRNOG00000024886 0.51 0.15 0.0e+00 0.36 0.38 0.4 0.41 6.9e-29 2.1e-30 3.7e-32 7.2e-33

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail4.213.621.84.1-3.14.43.5-3.24.7-1.14.2
BMI without tail4.38.913.43.4-2.73.52.9-2.63.7-1.03.3
Body weight5.222.029.45.2-4.15.44.8-4.55.1-2.25.4
Epididymis fat weight1.84.212.11.1-2.60.82.1-2.4-1.4-3.51.1
Glucose1.21.84.4-1.60.9-1.7-0.90.8-2.1-0.2-1.6
Heart weight0.81.22.9-0.91.7-0.5-1.11.10.41.5-0.7
Left kidney weight0.30.81.20.8-1.10.80.9-1.00.2-1.00.8
Right kidney weight0.51.41.81.2-1.21.21.3-1.40.8-1.01.3
Tail length0.41.11.51.2-1.21.11.0-1.01.2-0.41.2
Length with tail1.45.16.52.5-2.22.42.5-2.41.8-1.52.5
Length without tail1.73.75.42.1-1.42.22.1-2.11.5-1.32.3
Liver weight, left0.61.01.70.9-0.60.91.2-1.30.3-1.31.0
Liver weight, right3.15.27.52.5-1.52.72.5-2.42.2-1.42.7
Parametrial fat weight4.28.311.63.0-2.63.03.3-3.41.4-2.83.1
Retroperitoneal fat weight1.13.75.31.9-1.52.02.3-2.31.2-1.82.1
Intraocular pressure0.50.82.41.0-0.90.90.3-0.11.50.60.7
Extensor digitorum longus weight2.911.829.04.1-3.04.12.2-2.05.40.43.7
Soleus weight2.16.28.62.9-2.42.92.3-2.22.7-1.02.8
Tibialis anterior weight2.07.024.53.0-1.73.10.9-0.65.01.72.6
Tibia length3.08.411.63.4-2.63.42.8-2.73.1-1.63.3
Number of licking bursts0.20.20.40.3-0.40.40.6-0.50.0-0.60.3
Food consumed during 24 hour testing period1.11.33.90.6-1.30.51.2-1.4-0.8-2.00.6
Times rat made contact with spout0.91.13.7-0.1-0.9-0.20.8-1.0-1.5-1.9-0.1
Mean time between licks in bursts0.50.82.0-0.60.9-0.5-1.01.10.31.4-0.5
Mean num. licks in bursts0.20.20.5-0.50.0-0.7-0.40.3-0.7-0.0-0.5
Std. dev. time between licks in bursts0.50.61.0-0.91.0-0.7-0.90.9-0.50.8-0.7
Water consumed over 24 hours2.63.16.61.4-2.11.22.0-2.2-0.2-2.61.3
Indifference point 0 sec1.62.63.51.6-1.81.51.8-1.91.0-1.51.7
Indifference point AUC1.72.02.41.5-1.61.41.5-1.51.0-1.21.4
Indifference point function ln k0.40.60.9-0.90.9-0.9-0.80.7-0.90.4-0.7
Indifference point function log k0.40.60.9-0.90.9-0.9-0.80.7-0.90.4-0.7
Delay discounting total patch changes 0 sec1.11.82.41.3-1.61.21.5-1.60.8-1.21.4
Delay discounting total patch changes 12 sec1.82.43.71.4-1.91.21.8-1.80.4-1.91.3
Delay discounting total patch changes 18 sec2.53.45.32.1-1.92.11.6-1.52.3-0.42.1
Delay discounting total patch changes 24 sec0.10.10.5-0.0-0.4-0.10.2-0.4-0.5-0.7-0.1
Delay discounting total patch changes 6 sec2.23.46.71.5-2.21.32.2-2.20.2-2.61.5
Delay discounting time to switch 0 sec1.52.34.1-1.71.0-1.8-1.61.3-2.00.4-1.7
Delay discounting water rate 0 sec1.42.24.21.6-1.01.71.5-1.22.0-0.11.7
Delay discounting water rate 12 sec0.20.31.30.5-0.00.60.2-0.21.10.50.5
Delay discounting water rate 18 sec0.60.81.30.9-0.30.91.1-1.10.6-0.71.0
Delay discounting water rate 24 sec0.30.40.80.6-0.20.60.7-0.90.1-0.50.7
Delay discounting water rate 6 sec1.11.55.41.2-0.31.40.6-0.42.31.01.3
Locomotor activity1.93.05.12.0-0.72.11.7-1.62.3-0.12.2
Locomotor testing distance0.50.91.71.0-0.11.20.9-0.81.30.11.3
Locomotor testing rearing0.81.32.01.2-0.91.21.3-1.30.6-0.91.4
Light reinforcement 10.10.21.0-0.50.0-0.5-0.30.1-1.0-0.3-0.4
Light reinforcement 20.30.41.8-0.5-0.2-0.6-0.00.0-1.3-0.6-0.6
Reaction time number correct1.72.53.61.6-1.11.61.9-1.90.5-1.81.6
Reaction time mean minus median1.72.24.21.6-2.01.41.5-1.50.8-1.41.3
Reaction time mean minus median AUC0.20.20.60.4-0.80.40.3-0.40.1-0.40.3
Reaction time num false alarms0.50.61.00.9-1.00.80.8-0.80.6-0.30.9
Reaction time num false alarms AUC0.40.51.10.8-1.10.70.6-0.60.5-0.20.8
Reaction time trials correct on left1.72.53.61.6-1.11.61.9-1.90.5-1.81.6
Reaction time trials on left2.02.84.01.7-1.31.72.0-2.00.6-1.91.7
Reaction time mean1.31.82.91.5-1.71.41.4-1.31.1-0.91.3
Reaction time mean AUC1.41.82.51.5-1.61.41.5-1.40.9-1.11.4
Median of all reaction times0.60.91.31.0-1.11.01.0-0.90.8-0.60.9
Reaction time omissions0.40.50.70.7-0.80.60.7-0.90.0-0.80.7
Reaction time false alarm rate0.20.31.6-0.0-0.1-0.1-0.60.60.71.3-0.1
Reaction time premature initiation rate0.10.10.30.3-0.30.3-0.20.10.60.50.3
Reaction time premature initiations0.30.50.70.8-0.70.80.6-0.70.4-0.50.8
Std. dev. reaction times2.33.25.11.9-2.31.81.9-1.81.0-1.61.6
Reaction time trials completed2.02.84.01.7-1.31.72.0-2.00.6-1.91.7
Reaction time trials AUC1.82.63.71.6-1.21.71.9-1.90.6-1.81.7
Social response proportion0.70.73.00.7-0.20.80.00.01.71.10.7
Social responses1.21.66.11.0-0.21.20.00.12.51.61.1
Social time0.30.51.70.2-0.50.0-0.70.60.91.3-0.0
Conditioned locomotion0.30.40.50.7-0.70.60.6-0.60.2-0.60.7
Cocaine response after cond. corrected0.50.61.1-0.90.4-1.0-0.60.6-1.00.1-0.9
Cocaine response after cond. not corrected0.80.81.2-1.00.5-1.1-1.01.0-0.80.7-1.1
Cocaine response before conditioning0.20.31.00.00.00.0-0.50.60.71.0-0.2
Saline control response0.71.02.90.9-1.70.70.9-1.00.2-1.00.8
Condit. Reinf. active minus inactive responses1.62.03.11.6-0.81.81.4-1.21.8-0.61.6
Condit. Reinf. active-inactive response ratio2.12.23.51.7-1.11.81.4-1.21.9-0.51.7
Condit. Reinf. active responses2.83.96.72.2-1.22.51.9-1.62.6-0.72.3
Condit. Reinf. inactive responses0.40.41.10.8-0.30.90.6-0.41.0-0.00.7
Condit. Reinf. lever presses0.30.41.2-0.10.70.0-0.40.70.91.1-0.1
Condit. Reinf. lever reinforcers received2.33.26.32.1-1.02.31.7-1.42.5-0.42.1
Pavlov. Cond. lever latency0.00.00.10.0-0.30.0-0.0-0.1-0.2-0.1-0.1
Pavlov. Cond. magazine entry latency0.00.00.10.10.00.20.2-0.10.30.00.2
Pavlov. Cond. change in total contacts0.50.73.00.60.30.70.10.21.71.00.6
Pavlov. Cond. index score0.10.10.30.4-0.20.30.4-0.30.6-0.10.4
Pavlov. Cond. latency score0.00.00.20.2-0.00.20.2-0.10.50.10.2
Pavlov. Cond. lever contacts0.10.10.2-0.30.5-0.3-0.30.4-0.10.4-0.3
Pavlov. Cond. magazine entry number0.50.61.2-0.90.6-0.9-0.80.7-1.10.3-0.9
Pavlov. Cond. intertrial magazine entries1.01.43.10.9-1.30.81.4-1.4-0.3-1.80.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.30.5-0.40.40.5-0.40.6-0.20.5
Pavlov. Cond. response bias0.10.10.50.20.30.30.2-0.00.70.30.3
Conditioned reinforcement - actives0.10.10.20.10.10.30.2-0.20.40.10.2
Conditioned reinforcement - inactives0.50.61.20.8-0.20.90.9-0.71.1-0.01.0
Conditioned locomotion2.22.64.01.6-1.21.72.0-2.01.1-1.51.7
Intermittent access intake day 1-15 change0.80.83.4-1.01.8-0.7-0.50.7-0.30.6-0.7
Intermittent access intake escalation0.70.72.5-1.01.6-0.7-0.40.6-0.50.3-0.7
Intermittent access intake escalation 20.70.72.5-0.61.6-0.4-0.50.70.41.2-0.3
Intermitt. access day 1 inactive lever presses0.50.61.00.7-1.00.60.9-0.90.1-0.90.7
Intermitt. access day 15 inactive lever presses1.41.53.00.9-0.21.21.7-1.60.4-1.71.2
Intermitt. access escalation Index0.90.83.4-0.60.0-0.8-0.30.0-1.9-1.3-0.7
Intermittent access day 1 total infusions0.40.40.9-0.90.6-0.7-0.60.3-0.9-0.2-0.7
Intermittent access day 15 total infusions1.11.22.4-1.41.6-1.2-0.70.7-1.3-0.1-1.1
Intermittent access terminal intake (last 3 days)0.40.41.6-0.81.3-0.5-0.40.4-0.40.3-0.5
Intermittent access total infusions0.50.61.7-0.91.3-0.7-0.60.6-0.40.6-0.7
Intermittent access day 1 locomotion0.10.10.3-0.20.5-0.00.1-0.4-0.4-0.60.0
Intermittent access day 15 total locomotion0.91.01.80.8-0.31.01.3-1.30.6-1.21.0
Intermittent access total locomotion0.60.71.20.70.11.00.9-0.91.1-0.21.0
Intermittent access standard deviation0.30.31.8-0.11.30.10.10.00.60.70.3
Cocaine induced anxiety0.30.30.6-0.60.3-0.7-0.60.4-0.70.0-0.7
Post-drug Anxiety2.73.04.1-1.71.8-1.6-2.02.0-0.52.0-1.7
Baseline Anxiety0.70.82.70.5-0.20.6-0.10.51.61.50.4
Lifetime Intake0.40.41.6-0.81.3-0.6-0.40.4-0.50.2-0.6
Incentive Sensitization - Responses0.30.31.10.5-0.10.70.5-0.41.00.20.7
Incentive Sensitization - Breakpoint0.20.20.80.3-0.00.50.4-0.30.90.30.5
Progressive ratio test 1 active lever presses0.40.41.2-0.20.90.00.7-0.7-0.4-1.10.2
Progressive ratio test 1 breakpoint0.30.31.1-0.21.1-0.00.6-0.6-0.3-0.90.1
Progressive ratio test 1 inactive lever presses0.30.41.2-0.30.7-0.20.4-0.5-0.8-1.1-0.0
Progressive ratio test 2 active lever presses0.20.20.40.00.50.30.6-0.60.2-0.50.4
Progressive ratio test 2 breakpoint0.10.10.9-0.30.9-0.00.3-0.3-0.0-0.30.0
Progressive ratio test 2 inactive lever presses0.20.20.40.20.30.50.5-0.40.6-0.00.5
Total sessions with >9 infusions1.01.14.40.10.30.21.2-1.3-0.9-2.10.5
Short access day 1 total inactive lever presses0.40.40.60.6-0.80.60.7-0.80.4-0.60.7
Short access day 10 total inactive lever presses0.70.81.60.9-1.30.70.9-0.90.3-0.70.9
Short access day 1 total infusions0.70.72.40.5-0.30.41.1-1.2-0.3-1.60.6
Short access day 10 total infusions0.00.00.3-0.10.5-0.1-0.0-0.00.10.1-0.0
Short access total infusions0.30.30.9-0.60.9-0.5-0.10.0-0.7-0.4-0.4
Short access day 1 locomotion1.11.12.30.8-0.30.91.4-1.50.3-1.51.1
Short access day 10 total locomotion0.80.92.40.6-0.20.61.1-1.3-0.2-1.50.9
Short access total locomotion1.51.63.50.9-0.21.01.6-1.80.2-1.91.2
Compulsive drug intake1.21.22.0-1.10.3-1.1-1.41.4-0.71.1-1.2
One hour access (0.3 mA shock)0.40.51.70.50.20.70.2-0.11.31.00.6
One hour access (shock baseline)0.60.71.10.8-0.10.91.0-0.91.0-0.41.0
Number of responses in last shaping day0.30.31.00.3-0.3-0.00.6-0.6-0.7-1.00.2
Context. condit. distance diff. score1.41.72.41.5-1.21.51.3-1.11.4-0.61.4
Locomotion velocity, session 10.20.20.50.40.20.50.7-0.70.1-0.50.6
Locomotion distance, session 10.10.10.20.3-0.20.30.5-0.40.2-0.30.4
Locomotion velocity, session 23.84.46.7-2.32.6-2.2-2.22.1-1.41.7-2.1
Locomotion distance, session 20.40.60.8-0.80.6-0.9-0.90.9-0.30.9-0.7
Locomotion velocity, session 32.93.44.52.0-1.22.12.1-1.91.7-1.42.1
Locomotion distance, session 32.22.43.01.7-1.51.61.7-1.61.2-1.31.7
Stereotopy head waving bouts, day 30.40.50.80.7-0.20.90.8-0.80.6-0.50.9
Stereotopy head waving duration, day 30.30.31.1-0.00.70.2-0.40.50.71.00.1
Locomotion velocity, session 70.30.31.30.6-0.50.60.10.01.20.50.5
Locomotion distance, session 71.62.04.01.7-2.01.51.0-0.81.8-0.11.4
Stereotopy head waving bouts, day 74.14.68.1-1.92.6-1.6-2.42.5-0.02.8-1.8
Stereotopy head waving duration, day 72.63.25.1-1.72.3-1.5-2.02.0-0.42.1-1.7
Locomotion velocity, session 80.10.10.20.4-0.40.40.3-0.30.3-0.10.3
Locomotion distance, session 80.91.32.11.3-1.41.21.1-0.91.4-0.31.2
Degree of sensitization distance0.10.10.30.1-0.30.0-0.30.30.40.5-0.1
Degree of sensitization stereotypy5.66.17.9-2.52.8-2.3-2.82.8-0.92.7-2.5
Condit. Reinf. active minus inactive responses0.20.21.0-0.0-0.10.00.6-0.6-0.5-1.00.1
Condit. Reinf. active-inactive response ratio1.61.72.6-1.61.5-1.5-1.00.9-1.50.3-1.5
Condit. Reinf. active responses1.51.83.01.2-1.01.31.7-1.70.5-1.71.3
Condit. Reinf. inactive responses4.35.16.22.5-2.02.52.5-2.41.8-1.82.5
Incentive salience index mean0.70.81.80.7-0.60.71.2-1.20.1-1.40.8
Condit. Reinf. lever presses0.50.71.10.8-0.50.91.1-1.00.6-0.80.9
Time in familiar zone, hab. session 10.60.51.4-0.2-0.6-0.4-1.01.00.21.2-0.5
Time in novel zone, hab. session 10.50.51.7-0.10.20.00.7-0.8-0.8-1.30.1
Total zone transitions, hab. session 10.50.72.80.5-0.00.6-0.30.51.71.40.4
Total locomotion distance, hab. session 11.31.92.91.6-1.01.71.2-1.11.7-0.31.7
Locomotion velocity, hab. session 11.11.63.11.5-0.81.61.1-1.01.8-0.21.5
Time in familiar zone, hab. session 20.90.91.6-0.90.4-1.0-1.21.3-0.31.2-1.0
Time in novel zone, hab. session 21.11.11.51.1-0.51.21.2-1.20.8-0.91.2
Total zone transitions, hab. session 20.10.10.40.4-0.70.20.3-0.30.2-0.20.4
Total locomotion distance, hab. session 20.30.40.60.5-0.60.50.7-0.70.1-0.70.7
Locomotion velocity, hab. session 20.20.20.50.3-0.40.20.6-0.6-0.2-0.70.4
Novel to familiar place preference ratio0.10.10.6-0.10.8-0.00.1-0.2-0.3-0.20.0
Novelty place preference0.20.21.3-0.41.1-0.2-0.20.1-0.30.1-0.2
Time in novel zone, NPP test0.20.21.1-0.41.1-0.2-0.20.2-0.20.3-0.2
Total zone transitions, NPP test1.62.34.61.8-1.41.81.3-1.02.1-0.11.7
Total locomotion distance, NPP test1.92.63.61.9-1.41.91.6-1.41.8-0.71.9
Locomotion velocity, NPP test1.92.73.71.9-1.31.91.7-1.51.8-0.81.9
Pavlov. Cond. lever latency0.50.61.0-0.71.0-0.6-0.80.9-0.20.9-0.7
Pavlov. Cond. magazine entry latency0.00.00.1-0.0-0.4-0.1-0.10.0-0.0-0.0-0.1
Pavlov. Cond. change in total contacts0.20.20.4-0.60.4-0.6-0.40.3-0.6-0.0-0.6
Pavlov. Cond. index score0.10.10.30.3-0.50.30.2-0.30.3-0.20.2
Pavlov. Cond. latency score0.20.30.50.5-0.70.40.5-0.50.3-0.50.4
Pavlov. Cond. lever contacts0.80.91.51.0-1.20.91.0-1.10.5-1.00.9
Pavlov. Cond. magazine entry number0.00.00.0-0.00.1-0.0-0.10.10.00.10.0
Pavlov. Cond. intertrial magazine entries1.72.03.51.2-1.31.21.7-1.70.1-1.91.4
Pavlov. Cond. lever-magazine prob. diff.0.30.30.60.5-0.80.40.6-0.70.2-0.70.5
Pavlov. Cond. response bias0.00.00.10.2-0.20.20.2-0.20.1-0.20.2
Bone: apparent density0.30.62.0-0.10.70.0-0.70.81.01.4-0.1
Bone surface0.10.10.50.20.20.3-0.10.10.70.50.2
Bone volume0.40.62.0-0.40.7-0.3-0.91.00.61.4-0.5
Bone: connectivity density0.00.10.2-0.20.4-0.1-0.20.30.20.4-0.2
Bone: cortical apparent density1.01.21.9-1.21.4-1.1-1.11.1-0.90.9-1.2
Bone: cortical area1.82.77.41.9-1.22.00.9-0.82.70.51.9
Bone: cortical porosity0.40.41.50.6-0.40.6-0.10.21.20.80.5
Bone: cortical porosity0.60.62.30.8-0.50.80.1-0.01.50.60.7
Bone: cortical thickness0.40.72.60.7-0.00.8-0.10.21.61.10.6
Bone: cortical thickness0.50.62.00.40.10.4-0.50.61.41.30.2
Bone: cortical tissue density1.01.31.9-1.31.4-1.2-1.11.1-1.00.8-1.2
Bone: elastic displacement3.03.47.4-1.52.0-1.3-2.22.30.22.7-1.4
Bone: elastic work1.41.96.2-0.51.3-0.3-1.51.61.22.5-0.5
Bone: endosteal estimation1.73.85.72.2-2.42.01.9-1.81.5-1.42.0
Bone: endosteal perimeter1.83.75.12.3-1.82.21.8-1.72.1-0.82.2
Bone: final force1.42.23.11.8-1.61.71.4-1.31.6-0.71.7
Bone: final moment0.81.32.11.4-1.21.40.9-0.81.4-0.21.3
Bone: marrow area1.84.06.02.3-2.52.12.0-1.91.6-1.42.0
Bone: maximum diameter2.64.76.42.5-2.32.42.0-2.02.2-1.12.5
Bone: maximum force2.23.96.12.4-2.02.31.6-1.52.5-0.42.2
Bone: maximum moment1.52.65.12.0-1.62.01.1-1.02.30.01.8
Bone: minimum diameter4.48.111.33.4-2.73.32.5-2.43.3-1.03.3
Bone: periosteal estimation2.14.36.22.5-2.22.41.8-1.72.4-0.72.3
Bone: periosteal perimeter2.43.95.72.4-2.12.31.6-1.62.4-0.52.3
Bone: post-yield work2.83.96.52.1-2.51.92.0-2.11.1-1.82.0
Bone: stiffness1.32.12.71.6-1.61.61.4-1.41.3-0.91.6
Bone: tissue strength0.20.20.2-0.40.5-0.4-0.40.5-0.30.4-0.4
Bone: trabecular number1.01.64.6-0.71.3-0.5-1.41.60.92.1-0.8
Bone: trabecular spacing0.20.21.0-0.3-0.3-0.40.0-0.1-1.0-0.6-0.4
Bone: trabecular thickness0.40.41.4-0.10.70.1-0.60.60.91.2-0.1
Bone: trabecular tissue density0.91.24.9-1.00.9-0.90.2-0.3-2.2-1.3-0.8
Breakpoint value in progressive ratio session0.40.41.80.0-0.3-0.00.4-0.6-0.9-1.30.1
Distance traveled before self-admin1.51.62.11.4-1.31.41.3-1.31.3-0.71.5
Distance traveled after self-admin0.00.00.20.0-0.50.00.1-0.1-0.1-0.30.0
Delta time in closed arm before/after self-admin1.11.11.6-1.11.3-1.2-1.11.1-0.70.7-1.1
Delta time in open arm before/after self-admin0.20.20.40.4-0.40.40.5-0.6-0.1-0.60.5
Diff in mean of infusions in LGA sessions0.10.10.2-0.40.2-0.4-0.30.2-0.40.0-0.4
Extinction: sum of active levers before priming0.30.31.0-0.50.3-0.6-0.20.1-1.0-0.6-0.3
Active lever presses in extinction session 60.00.00.1-0.20.2-0.2-0.10.1-0.3-0.1-0.2
Delta distance traveled before/after self-admin0.20.20.3-0.5-0.2-0.6-0.50.6-0.50.2-0.6
Delta ambulatory time before/after self-admin0.40.40.7-0.7-0.1-0.7-0.70.8-0.60.3-0.8
Time in closed arm before self-admin0.91.02.00.8-1.40.71.1-1.10.0-1.30.8
Time in closed arm after self-admin1.51.62.4-1.41.0-1.5-1.21.2-1.60.3-1.5
Time in open arm before self-admin0.30.31.10.30.30.3-0.00.11.00.90.4
Time in open arm after self-admin0.80.91.41.0-0.50.91.1-1.20.4-1.01.1
Sum of active levers in priming session hrs 5-60.60.61.90.8-0.50.80.2-0.21.40.70.9
Time to tail flick, vehicle, before self-admin0.00.00.2-0.1-0.2-0.2-0.0-0.1-0.4-0.3-0.1
Time to tail flick, vehicle, after self-admin2.83.04.91.6-2.11.41.9-2.00.2-2.21.6
Time to tail flick, test, before self-admin0.70.71.70.7-1.30.60.8-0.80.0-1.10.7
Time to tail flick, test, after self-admin0.00.00.10.1-0.40.0-0.10.10.00.0-0.0
Delta time to tail flick, vehicle, before/after SA1.11.11.71.1-1.31.11.1-1.00.8-0.71.0
Delta time to tail flick, test, before/after SA0.20.20.50.4-0.00.40.0-0.10.70.50.3
Ambulatory time before self-admin1.31.41.81.3-1.11.31.2-1.31.0-0.81.3
Ambulatory time after self-admin0.10.10.30.1-0.60.10.2-0.2-0.1-0.40.1
Total heroin consumption1.11.34.00.8-1.10.61.3-1.4-0.6-2.00.8
Area under the delay curve0.60.60.9-0.90.4-0.9-0.90.8-0.80.4-0.9
Delay disc. indifference point, 0s delay0.10.10.30.0-0.5-0.00.2-0.3-0.5-0.40.1
Delay disc. indifference point, 16s delay2.32.33.1-1.61.2-1.6-1.71.8-1.11.3-1.7
Delay disc. indifference point, 2s delay0.80.91.3-1.10.8-1.1-1.11.0-0.80.7-0.9
Delay disc. indifference point, 24s delay0.20.20.5-0.3-0.7-0.4-0.50.4-0.40.2-0.5
Delay disc. indifference point, 4s delay0.10.10.2-0.30.0-0.3-0.50.4-0.10.4-0.3
Delay disc. indifference point, 8s delay0.30.30.70.2-0.70.10.5-0.6-0.4-0.80.3
Delay discount exponential model param0.70.81.21.0-0.41.11.0-0.90.9-0.41.0
Delay discount hyperbolic model param0.70.71.01.0-0.41.01.0-0.90.8-0.51.0
Fecal boli incidents, locomotor time 10.50.60.9-0.6-0.0-0.8-1.00.9-0.50.7-1.0
Change in fecal boli incidents, locomotor task0.00.00.10.10.10.10.2-0.20.2-0.20.3
Time >=10cm from walls, locomotor time 12.72.74.01.8-1.01.81.9-1.91.2-1.32.0
Bouts of movement, locomotor time 11.21.32.4-1.10.5-1.0-1.51.5-0.31.5-1.2
Total resting periods, locomotor time 11.61.82.6-1.31.0-1.2-1.61.6-0.51.6-1.4
Rest time, locomotor task time 11.92.14.0-1.70.9-1.8-1.31.1-2.00.2-1.7
Distance moved, locomotor task time 10.40.41.50.30.30.4-0.30.41.21.10.4
Vertical activity count, locomotor time 10.40.41.00.8-0.40.80.4-0.31.00.10.7
Time >=10cm from walls, locomotor time 22.52.73.61.7-1.71.61.8-1.90.8-1.61.8
Bouts of movement, locomotor time 20.60.71.1-0.7-0.0-0.8-1.11.0-0.70.8-1.0
Total resting periods, locomotor time 20.70.71.2-0.7-0.0-0.8-1.01.1-0.80.7-1.1
Rest time, locomotor task time 21.51.73.1-1.50.7-1.6-1.11.2-1.60.2-1.8
Distance moved, locomotor task time 20.80.93.20.8-0.00.90.00.11.81.20.9
Vertical activity count, locomotor time 22.12.33.51.9-1.51.81.2-1.11.7-0.31.8
Weight adjusted by age1.31.43.11.4-0.71.41.1-0.81.80.31.4
Seeking ratio, delayed vs. immediate footshock0.20.30.50.40.10.30.7-0.70.2-0.70.6
Locomotion in novel chamber0.70.92.80.9-0.11.10.8-0.61.70.41.1
Locomotion in novel chamber post-restriction0.10.10.20.3-0.20.30.4-0.3-0.0-0.40.2
Progressive ratio1.61.93.9-1.22.0-0.9-1.51.6-0.01.8-1.0
Food seeking constrained by brief footshock0.10.20.90.2-0.90.10.2-0.3-0.1-0.40.1
Seeking ratio, punishment vs. effort1.51.84.61.1-2.20.91.4-1.50.0-1.70.9
Run reversals in cocaine runway, females1.41.42.4-1.40.6-1.4-1.11.1-1.50.2-1.6
Run reversals in cocaine runway, males0.50.40.70.6-0.80.60.9-0.70.4-0.70.5
Latency to leave start box in cocaine runway8.69.511.8-3.43.1-3.4-3.22.8-3.31.3-3.4
Latency to leave start box in cocaine runway, F9.09.914.7-3.52.9-3.6-3.12.7-3.80.9-3.6
Latency to leave start box in cocaine runway, M0.90.92.0-0.81.4-0.6-1.01.0-0.21.2-0.7
Cd content in liver2.12.33.1-1.61.6-1.6-1.81.7-0.81.5-1.5
Co content in liver0.70.82.4-0.50.6-0.5-1.11.20.61.5-0.6
Cu content in liver1.21.55.6-1.30.9-1.3-0.30.1-2.4-1.0-1.0
Fe content in liver0.70.82.80.0-0.6-0.10.7-0.9-1.3-1.70.1
K content in liver5.15.112.61.6-2.01.42.6-3.0-0.7-3.61.9
Mg content in liver1.01.13.40.4-0.80.21.1-1.4-0.8-1.90.6
Mn content in liver0.40.41.30.20.10.30.8-1.0-0.4-1.10.6
Na content in liver3.23.411.40.6-1.40.31.8-2.3-2.0-3.40.9
Rb content in liver0.40.51.80.1-0.7-0.00.8-0.8-0.8-1.40.1
Se content in liver0.20.20.5-0.10.4-0.00.3-0.6-0.6-0.70.2
Sr content in liver1.21.11.41.2-1.11.11.0-0.91.1-0.41.2
Zn content in liver1.01.12.40.8-1.20.71.2-1.3-0.2-1.50.7