Hub : Genes

Men1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000021054	0.15	0.07	0.0e+00	0.11	0.12	0.12	0.12	2.9e-12	2.7e-13	4.0e-13	2.7e-13
2	Brain	gene expression	ENSRNOG00000021054	0.11	0.06	3.1e-06	0.08	0.08	0.07	0.08	5.3e-08	6.4e-08	5.4e-07	4.2e-08
3	LHb	mRNA stability	ENSRNOG00000021054	0.14	0.09	8.9e-03	0	-0.01	0.01	0.03	2.7e-01	6.5e-01	2.1e-01	6.9e-02
4	Liver	gene expression	ENSRNOG00000021054	0.03	0.02	5.7e-03	0	0	-0	-0	1.4e-01	3.0e-01	7.2e-01	7.6e-01
5	PL	gene expression	ENSRNOG00000021054	0.04	0.03	9.5e-03	-0	0.02	0	-0	6.0e-01	2.2e-02	2.5e-01	4.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.6	5.3	10.0	-3.0	-0.0	1.6	-2.3	-3.2
BMI without tail	0.8	1.7	2.9	-1.7	0.7	0.4	-1.6	-1.5
Body weight	2.5	10.5	17.1	-4.1	-0.2	2.5	-3.7	-3.9
Epididymis fat weight	1.6	3.8	8.3	2.4	-0.4	-1.2	2.9	1.9
Glucose	1.2	1.9	3.6	1.7	-0.0	-1.0	1.9	1.3
Heart weight	3.5	5.0	6.8	2.6	1.2	-2.2	2.3	2.6
Left kidney weight	0.3	0.9	2.0	1.1	-0.9	-0.1	1.4	0.8
Right kidney weight	0.4	1.0	3.2	0.2	-1.8	1.1	0.7	-0.3
Tail length	0.4	1.2	2.9	-1.4	0.7	0.4	-1.7	-0.8
Length with tail	1.3	4.8	7.8	-2.8	-0.2	1.8	-2.7	-2.4
Length without tail	1.3	2.9	4.4	-2.1	-0.4	1.6	-1.8	-2.0
Liver weight, left	0.0	0.1	0.2	0.2	-0.1	-0.1	0.5	0.1
Liver weight, right	0.3	0.5	1.1	0.4	1.0	-1.0	0.4	0.5
Parametrial fat weight	1.2	2.3	5.1	1.8	-0.5	-0.9	2.3	1.4
Retroperitoneal fat weight	3.8	12.6	23.4	4.4	-0.0	-2.5	4.8	3.7
Intraocular pressure	0.7	0.9	3.3	0.7	-1.8	0.7	0.6	0.3
Extensor digitorum longus weight	5.5	22.1	33.8	-5.8	-0.6	3.8	-5.7	-5.4
Soleus weight	3.1	9.2	13.9	3.7	0.6	-2.5	3.6	3.4
Tibialis anterior weight	8.5	29.3	43.3	-6.6	-1.3	4.7	-6.4	-6.1
Tibia length	2.7	7.7	11.7	-2.4	-3.1	3.4	-1.6	-3.0
Number of licking bursts	0.3	0.4	0.5	-0.6	-0.5	0.7	-0.5	-0.7
Food consumed during 24 hour testing period	0.4	0.4	0.9	-0.4	-1.0	0.9	-0.2	-0.5
Times rat made contact with spout	0.2	0.3	0.6	-0.6	0.6	-0.1	-0.8	-0.2
Mean time between licks in bursts	0.8	1.0	3.5	-0.3	1.9	-1.0	-0.8	0.3
Mean num. licks in bursts	0.4	0.5	0.7	0.6	0.8	-0.9	0.3	0.8
Std. dev. time between licks in bursts	1.5	1.7	3.9	0.8	2.0	-1.6	0.3	1.2
Water consumed over 24 hours	0.5	0.6	1.3	-1.0	0.1	0.5	-1.1	-0.6
Indifference point 0 sec	0.0	0.0	0.1	0.3	-0.1	0.0	0.2	0.2
Indifference point AUC	4.0	4.7	6.2	-2.5	-1.4	2.2	-2.1	-2.5
Indifference point function ln k	9.8	13.9	18.2	4.2	2.5	-4.0	3.4	4.3
Indifference point function log k	9.8	13.9	18.2	4.2	2.5	-4.0	3.4	4.3
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.3	0.4	-0.3	0.1	0.4
Delay discounting total patch changes 12 sec	3.8	5.1	7.5	-2.7	-0.8	2.1	-2.5	-2.6
Delay discounting total patch changes 18 sec	0.9	1.2	1.5	-1.1	-0.9	1.2	-1.0	-1.2
Delay discounting total patch changes 24 sec	2.0	2.6	4.1	-1.9	-0.5	1.4	-2.0	-1.7
Delay discounting total patch changes 6 sec	0.4	0.6	1.0	-1.0	0.3	0.4	-1.0	-0.8
Delay discounting time to switch 0 sec	1.9	2.9	4.9	-1.9	-1.2	1.8	-1.1	-2.2
Delay discounting water rate 0 sec	3.2	5.0	8.1	2.8	0.8	-2.2	1.9	2.8
Delay discounting water rate 12 sec	9.1	13.7	20.3	4.2	2.4	-3.9	2.9	4.5
Delay discounting water rate 18 sec	4.3	5.8	7.8	2.6	1.9	-2.7	1.7	2.8
Delay discounting water rate 24 sec	3.9	5.4	8.1	2.8	1.4	-2.5	1.8	2.8
Delay discounting water rate 6 sec	5.4	7.8	11.2	3.0	2.3	-3.2	1.7	3.3
Locomotor activity	3.1	4.9	6.6	2.3	1.9	-2.6	1.5	2.6
Locomotor testing distance	4.9	8.1	11.5	2.8	2.7	-3.4	1.8	3.2
Locomotor testing rearing	3.4	5.4	7.2	2.4	2.1	-2.7	1.7	2.7
Light reinforcement 1	0.1	0.2	0.4	0.5	0.3	-0.4	0.5	0.6
Light reinforcement 2	0.9	1.2	3.2	0.7	-1.8	0.8	1.3	0.1
Reaction time number correct	0.2	0.3	0.7	-0.6	0.1	0.3	-0.8	-0.5
Reaction time mean minus median	4.9	6.4	8.6	-2.6	-2.1	2.9	-2.1	-2.8
Reaction time mean minus median AUC	2.5	3.2	4.3	-1.9	-1.4	2.1	-1.6	-2.0
Reaction time num false alarms	2.0	2.7	5.1	1.2	2.3	-2.0	0.5	1.7
Reaction time num false alarms AUC	1.1	1.6	4.4	0.5	2.1	-1.5	-0.1	1.0
Reaction time trials correct on left	0.2	0.3	0.7	-0.6	0.1	0.3	-0.8	-0.5
Reaction time trials on left	0.3	0.4	0.9	-0.7	0.1	0.4	-0.9	-0.6
Reaction time mean	0.7	0.9	2.1	-0.5	-1.4	1.3	-0.3	-0.8
Reaction time mean AUC	0.8	1.0	2.3	-0.5	-1.5	1.3	-0.3	-0.8
Median of all reaction times	0.3	0.4	1.3	0.0	-1.1	0.8	0.2	-0.2
Reaction time omissions	1.3	1.7	3.2	-1.3	-0.6	1.3	-1.8	-1.3
Reaction time false alarm rate	1.4	2.0	3.6	1.0	1.9	-1.7	0.7	1.4
Reaction time premature initiation rate	1.6	2.2	5.0	-1.5	1.7	-0.2	-2.2	-0.8
Reaction time premature initiations	2.3	3.3	8.3	-2.0	1.5	0.3	-2.9	-1.3
Std. dev. reaction times	1.9	2.6	4.0	-1.4	-1.7	2.0	-1.2	-1.7
Reaction time trials completed	0.3	0.4	0.9	-0.7	0.1	0.4	-0.9	-0.6
Reaction time trials AUC	0.1	0.2	0.5	-0.4	0.3	0.1	-0.7	-0.3
Social response proportion	1.1	1.2	1.7	-1.2	-0.8	1.2	-0.8	-1.3
Social responses	0.1	0.2	0.4	-0.6	0.0	0.3	-0.3	-0.5
Social time	0.2	0.2	0.4	-0.6	0.3	0.3	-0.5	-0.5
Conditioned locomotion	1.0	1.2	2.5	-1.3	0.1	0.7	-1.6	-1.2
Cocaine response after cond. corrected	2.5	2.7	3.7	1.7	1.5	-1.9	1.3	1.8
Cocaine response after cond. not corrected	1.9	2.1	2.9	1.4	1.3	-1.7	1.1	1.5
Cocaine response before conditioning	1.1	1.4	1.7	-1.2	-1.0	1.3	-1.1	-1.3
Saline control response	2.3	3.1	5.6	-2.3	0.4	1.0	-2.4	-1.9
Condit. Reinf. active minus inactive responses	0.3	0.3	1.2	0.1	-1.1	0.6	0.0	-0.2
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.7	0.5	-1.6	0.8	0.5	-0.2
Condit. Reinf. active responses	0.2	0.3	0.5	-0.3	-0.7	0.6	-0.3	-0.5
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.5	0.7	-0.2	-0.4	-0.2
Condit. Reinf. lever presses	3.1	4.3	5.6	-2.1	-1.8	2.4	-1.7	-2.4
Condit. Reinf. lever reinforcers received	0.6	0.8	1.1	-0.8	-1.0	1.0	-0.8	-0.9
Pavlov. Cond. lever latency	1.0	1.4	2.1	1.1	1.2	-1.4	0.6	1.4
Pavlov. Cond. magazine entry latency	3.2	3.6	5.4	-2.3	-0.8	1.8	-1.9	-2.3
Pavlov. Cond. change in total contacts	4.1	5.7	8.3	-2.2	-2.5	2.9	-1.6	-2.6
Pavlov. Cond. index score	3.4	4.4	6.0	-2.2	-1.7	2.4	-1.6	-2.5
Pavlov. Cond. latency score	2.8	3.6	5.0	-2.0	-1.6	2.2	-1.3	-2.2
Pavlov. Cond. lever contacts	1.0	1.4	2.2	-1.1	-1.3	1.5	-0.6	-1.3
Pavlov. Cond. magazine entry number	6.6	8.1	10.8	3.3	1.6	-2.9	2.8	3.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	1.2	0.1	-0.8	1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.8	6.7	-2.4	-1.6	2.4	-1.8	-2.6
Pavlov. Cond. response bias	2.5	3.5	4.6	-2.0	-1.5	2.1	-1.4	-2.1
Conditioned reinforcement - actives	0.9	0.9	2.9	0.1	-1.7	1.1	0.3	-0.3
Conditioned reinforcement - inactives	3.2	3.6	6.6	2.4	-1.6	-0.3	2.6	1.8
Conditioned locomotion	4.8	5.8	10.7	3.3	-0.5	-1.3	2.9	2.8
Intermittent access intake day 1-15 change	0.5	0.5	1.8	0.5	-1.3	0.5	0.5	0.2
Intermittent access intake escalation	0.4	0.4	1.4	0.5	-1.2	0.5	0.4	0.2
Intermittent access intake escalation 2	0.6	0.6	2.2	0.1	-1.5	0.8	-0.2	-0.2
Intermitt. access day 1 inactive lever presses	1.8	1.9	4.5	1.6	-0.6	-0.6	2.1	1.3
Intermitt. access day 15 inactive lever presses	1.9	2.1	4.9	1.5	-1.4	0.1	2.2	1.0
Intermitt. access escalation Index	4.4	3.9	4.7	2.0	1.6	-2.2	2.0	2.1
Intermittent access day 1 total infusions	3.4	3.8	8.3	2.5	-0.1	-1.1	2.9	1.8
Intermittent access day 15 total infusions	4.2	4.7	9.1	2.9	-1.2	-0.7	3.0	2.1
Intermittent access terminal intake (last 3 days)	2.9	3.1	6.7	2.2	-1.5	-0.1	2.6	1.3
Intermittent access total infusions	2.4	2.6	5.8	2.1	-1.0	-0.4	2.4	1.3
Intermittent access day 1 locomotion	3.5	3.6	5.7	2.2	1.0	-1.7	2.4	1.8
Intermittent access day 15 total locomotion	2.3	2.5	4.6	2.1	-0.9	-0.4	2.1	1.5
Intermittent access total locomotion	3.1	3.5	7.9	2.4	-1.0	-0.6	2.8	1.5
Intermittent access standard deviation	0.7	0.8	1.3	1.0	-1.0	0.1	1.1	0.7
Cocaine induced anxiety	0.4	0.4	1.0	-0.3	-1.0	0.9	-0.1	-0.6
Post-drug Anxiety	2.6	2.9	4.0	-1.5	-2.0	1.9	-1.3	-1.7
Baseline Anxiety	1.2	1.3	2.3	-1.5	-0.1	0.7	-1.5	-1.2
Lifetime Intake	2.2	2.5	5.0	2.1	-0.5	-0.7	2.2	1.4
Incentive Sensitization - Responses	0.5	0.5	1.4	0.5	-1.2	0.4	0.7	0.1
Incentive Sensitization - Breakpoint	0.6	0.6	1.4	0.7	-1.2	0.4	0.8	0.3
Progressive ratio test 1 active lever presses	1.8	1.9	3.5	1.8	-0.3	-0.7	1.9	1.5
Progressive ratio test 1 breakpoint	1.6	1.7	3.0	1.7	-0.2	-0.6	1.7	1.4
Progressive ratio test 1 inactive lever presses	1.3	1.4	2.0	1.4	0.3	-1.0	1.4	1.3
Progressive ratio test 2 active lever presses	2.4	2.6	4.6	2.1	-1.4	-0.3	2.1	1.4
Progressive ratio test 2 breakpoint	3.1	3.5	6.3	2.5	-1.0	-0.7	2.4	1.9
Progressive ratio test 2 inactive lever presses	4.9	5.7	11.2	3.0	-1.6	-0.7	3.4	2.2
Total sessions with >9 infusions	1.9	2.0	3.0	1.7	0.7	-1.4	1.6	1.5
Short access day 1 total inactive lever presses	3.3	3.6	6.1	2.5	0.5	-1.7	2.0	2.2
Short access day 10 total inactive lever presses	4.9	5.4	7.1	2.5	1.5	-2.5	2.3	2.7
Short access day 1 total infusions	2.1	2.2	3.6	1.9	0.2	-1.3	1.9	1.5
Short access day 10 total infusions	0.9	1.0	2.3	1.3	-0.1	-0.6	1.5	0.8
Short access total infusions	1.1	1.2	2.0	1.4	0.4	-1.0	1.3	1.1
Short access day 1 locomotion	1.9	2.0	3.3	1.8	0.6	-1.5	1.4	1.5
Short access day 10 total locomotion	1.4	1.5	2.2	1.5	0.7	-1.1	1.5	1.2
Short access total locomotion	1.4	1.4	2.0	1.4	0.8	-1.2	1.2	1.2
Compulsive drug intake	1.5	1.5	3.7	-1.2	1.9	-0.5	-1.4	-0.5
One hour access (0.3 mA shock)	5.9	6.9	12.2	3.5	-0.7	-1.4	3.4	2.8
One hour access (shock baseline)	4.5	5.2	8.6	2.9	-2.3	-0.1	2.9	1.9
Number of responses in last shaping day	1.5	1.5	2.5	1.5	0.7	-1.4	0.8	1.6
Context. condit. distance diff. score	2.0	2.4	3.2	1.7	0.9	-1.6	1.8	1.7
Locomotion velocity, session 1	0.3	0.4	1.1	0.2	1.0	-0.7	-0.3	0.4
Locomotion distance, session 1	0.2	0.3	0.6	-0.5	0.7	-0.2	-0.6	-0.4
Locomotion velocity, session 2	1.7	2.0	3.5	-1.9	0.0	1.1	-1.6	-1.7
Locomotion distance, session 2	0.3	0.4	0.7	-0.7	0.8	-0.1	-0.7	-0.5
Locomotion velocity, session 3	0.4	0.4	0.6	0.7	0.7	-0.8	0.6	0.5
Locomotion distance, session 3	0.1	0.1	0.2	0.3	0.3	-0.4	0.2	0.3
Stereotopy head waving bouts, day 3	0.9	1.1	1.5	1.1	1.0	-1.2	0.9	1.0
Stereotopy head waving duration, day 3	0.6	0.7	1.1	1.0	0.4	-0.8	0.9	0.9
Locomotion velocity, session 7	0.4	0.4	0.7	0.8	0.2	-0.6	0.9	0.5
Locomotion distance, session 7	0.6	0.8	1.4	0.6	1.2	-1.1	0.4	0.7
Stereotopy head waving bouts, day 7	0.3	0.4	1.2	0.1	-1.1	0.7	0.3	-0.3
Stereotopy head waving duration, day 7	1.6	2.0	2.6	-1.4	-1.2	1.6	-1.0	-1.6
Locomotion velocity, session 8	0.4	0.5	1.1	-0.8	1.0	-0.2	-0.7	-0.4
Locomotion distance, session 8	0.2	0.3	0.5	0.5	0.4	-0.6	0.7	0.4
Degree of sensitization distance	0.2	0.2	0.4	0.3	0.6	-0.5	0.3	0.3
Degree of sensitization stereotypy	1.5	1.7	2.6	-1.1	-1.5	1.6	-0.7	-1.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.3	0.2	0.0	-0.6	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.2	-0.1	0.1	0.0	-0.4	0.0
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.2	-0.4	0.2	0.5	-0.1
Incentive salience index mean	0.2	0.2	0.5	-0.5	0.2	0.1	-0.7	-0.5
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.7	-0.4	0.7	-0.6	-0.9
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.5	0.1	-0.4	0.7	0.4
Time in novel zone, hab. session 1	0.8	0.7	1.2	0.6	1.1	-1.1	0.2	0.9
Total zone transitions, hab. session 1	0.5	0.8	1.4	-1.0	-0.2	0.8	-1.2	-0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.6	0.0	-0.3	0.5	0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	-0.0
Time in familiar zone, hab. session 2	1.0	1.1	2.6	0.4	1.6	-1.4	0.3	0.8
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.4	-0.8	0.8	-0.5	-0.6
Total zone transitions, hab. session 2	0.8	1.0	1.6	-1.3	0.2	0.6	-1.2	-1.2
Total locomotion distance, hab. session 2	0.1	0.1	0.4	0.1	0.6	-0.5	0.2	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.1	0.3	0.2	-0.3	0.4	0.1
Novel to familiar place preference ratio	3.1	3.3	4.7	-1.6	-2.0	2.2	-1.2	-1.9
Novelty place preference	2.0	2.1	3.1	-1.2	-1.7	1.8	-0.8	-1.5
Time in novel zone, NPP test	1.4	1.5	2.2	-1.0	-1.4	1.5	-0.6	-1.3
Total zone transitions, NPP test	1.8	2.5	3.8	-1.9	-0.3	1.4	-1.8	-1.9
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.1	0.4	-0.1	-0.1	-0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.2	0.1	0.1	-0.3	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.7	0.3	-0.6	0.6	0.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.8	-0.6	0.8	-0.6	-0.9
Pavlov. Cond. change in total contacts	1.0	1.0	2.1	-0.6	-1.5	1.3	-0.4	-0.9
Pavlov. Cond. index score	0.4	0.5	0.7	-0.7	-0.7	0.8	-0.6	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.3	-0.5	-0.4	0.5	-0.3	-0.6
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.2	-0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.7	0.9	1.2	-1.3	0.7	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	0.8	-0.5	-0.1	0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.1	-0.9	-0.8	1.0	-0.8	-1.0
Pavlov. Cond. response bias	0.4	0.5	0.6	-0.6	-0.8	0.8	-0.6	-0.7
Bone: apparent density	0.4	0.6	1.2	-0.9	-0.5	0.8	0.1	-1.1
Bone surface	5.1	9.0	13.4	-3.3	-2.2	3.3	-2.2	-3.7
Bone volume	2.7	4.6	6.7	-2.0	-2.2	2.6	-0.9	-2.6
Bone: connectivity density	1.8	2.8	4.8	-2.1	-0.7	1.7	-1.1	-2.2
Bone: cortical apparent density	0.2	0.3	0.9	-0.5	0.2	0.1	-1.0	-0.2
Bone: cortical area	1.0	1.4	2.0	-1.2	-1.1	1.4	-0.7	-1.4
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.1	0.3	-0.1	-0.3
Bone: cortical porosity	0.4	0.4	0.7	-0.8	-0.0	0.6	-0.6	-0.7
Bone: cortical thickness	1.4	2.3	4.0	-2.0	0.3	0.9	-2.0	-1.5
Bone: cortical thickness	0.5	0.6	1.8	-0.4	1.3	-0.6	-0.8	0.1
Bone: cortical tissue density	0.3	0.3	1.2	-0.6	0.3	0.2	-1.1	-0.2
Bone: elastic displacement	2.5	2.8	3.9	1.6	1.7	-2.0	0.9	2.0
Bone: elastic work	0.6	0.8	2.4	-0.5	1.6	-0.7	-0.9	0.1
Bone: endosteal estimation	0.4	1.0	3.1	1.0	-0.6	-0.2	1.8	0.4
Bone: endosteal perimeter	0.8	1.6	3.7	1.0	-1.7	0.5	1.9	0.1
Bone: final force	2.6	4.2	6.4	-2.5	-0.9	2.0	-1.9	-2.5
Bone: final moment	2.3	3.7	5.7	-2.3	-0.9	1.9	-1.8	-2.4
Bone: marrow area	0.5	1.0	3.2	1.1	-0.5	-0.4	1.8	0.5
Bone: maximum diameter	1.1	2.0	3.6	-1.0	-1.9	1.8	-0.2	-1.5
Bone: maximum force	3.5	6.1	9.6	-2.8	-1.6	2.6	-2.0	-3.1
Bone: maximum moment	2.9	5.1	8.1	-2.6	-1.4	2.4	-1.8	-2.8
Bone: minimum diameter	0.4	0.8	2.5	0.9	-0.6	-0.2	1.6	0.4
Bone: periosteal estimation	0.4	0.8	1.8	-0.2	-1.3	1.0	0.6	-0.8
Bone: periosteal perimeter	0.6	1.0	1.8	-0.6	-1.3	1.2	0.1	-1.1
Bone: post-yield work	2.6	3.6	6.5	-1.2	-2.5	2.3	-0.1	-2.1
Bone: stiffness	3.4	5.4	8.0	-2.5	-1.8	2.6	-1.8	-2.8
Bone: tissue strength	0.3	0.3	0.6	-0.2	-0.8	0.7	-0.1	-0.4
Bone: trabecular number	1.1	1.6	2.5	-1.2	-1.4	1.6	-0.1	-1.5
Bone: trabecular spacing	0.9	1.2	2.0	0.8	1.4	-1.4	0.0	1.2
Bone: trabecular thickness	0.5	0.6	1.9	0.7	-0.4	-0.1	1.4	0.4
Bone: trabecular tissue density	2.3	3.3	5.7	2.2	-0.1	-1.2	2.4	2.0
Breakpoint value in progressive ratio session	3.2	3.6	4.8	-2.2	-1.2	2.0	-1.6	-2.2
Distance traveled before self-admin	1.5	1.6	2.4	-1.1	-1.3	1.5	-0.7	-1.4
Distance traveled after self-admin	0.5	0.6	0.9	-0.6	-0.9	1.0	-0.4	-0.7
Delta time in closed arm before/after self-admin	2.0	2.0	5.5	0.5	2.3	-1.8	-0.1	1.0
Delta time in open arm before/after self-admin	1.6	1.6	3.5	-0.8	-1.9	1.6	-0.0	-1.0
Diff in mean of infusions in LGA sessions	0.4	0.4	0.6	-0.8	-0.4	0.6	-0.8	-0.7
Extinction: sum of active levers before priming	3.9	4.0	6.1	-2.5	-0.9	2.0	-1.8	-2.4
Active lever presses in extinction session 6	3.9	3.7	5.1	-2.0	-1.6	2.3	-1.4	-2.2
Delta distance traveled before/after self-admin	0.4	0.5	0.8	0.5	0.9	-0.9	0.2	0.7
Delta ambulatory time before/after self-admin	0.6	0.6	1.4	0.4	1.2	-1.0	-0.0	0.7
Time in closed arm before self-admin	0.7	0.8	1.8	-0.5	-1.3	1.1	0.2	-0.8
Time in closed arm after self-admin	0.6	0.6	1.1	0.6	1.0	-1.0	0.4	0.7
Time in open arm before self-admin	3.8	4.0	7.6	1.4	2.8	-2.6	0.0	2.0
Time in open arm after self-admin	0.1	0.1	0.3	0.4	0.3	-0.4	0.0	0.6
Sum of active levers in priming session hrs 5-6	5.0	4.9	7.7	-1.7	-2.6	2.8	-1.6	-2.1
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.3	-1.0	-0.6	1.0	-0.9	-1.1
Time to tail flick, vehicle, after self-admin	0.9	1.0	1.5	-1.2	1.0	-0.1	-1.1	-1.0
Time to tail flick, test, before self-admin	1.4	1.4	2.1	1.1	1.2	-1.5	1.1	1.1
Time to tail flick, test, after self-admin	0.2	0.2	0.9	-0.2	-0.0	0.1	-0.9	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	-0.5	0.9	-0.4	-0.5	-0.3
Delta time to tail flick, test, before/after SA	2.5	2.2	4.2	-1.4	-1.1	1.5	-2.0	-1.2
Ambulatory time before self-admin	2.0	2.1	3.7	-1.1	-1.9	1.9	-0.4	-1.4
Ambulatory time after self-admin	0.5	0.5	1.6	-0.0	-1.3	0.8	0.4	-0.3
Total heroin consumption	4.7	5.6	8.4	-2.9	-0.7	2.1	-2.9	-2.6
Area under the delay curve	0.2	0.2	0.4	0.1	0.6	-0.6	-0.1	0.3
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	0.6	1.1	-1.2	0.6	0.8
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	0.9	-0.2	-0.4	0.9	0.7
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.2	0.0	-0.2	-0.0	0.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.4	0.4	1.2	-1.1	-0.2	0.7
Delay disc. indifference point, 4s delay	0.8	0.9	2.0	0.5	1.4	-1.3	0.2	0.8
Delay disc. indifference point, 8s delay	0.5	0.5	1.3	0.3	1.2	-0.9	0.1	0.6
Delay discount exponential model param	0.2	0.2	0.4	-0.1	-0.7	0.6	0.2	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.0	-0.7	0.5	0.3	-0.2
Fecal boli incidents, locomotor time 1	1.9	2.1	4.9	-0.8	-2.2	1.9	-0.2	-1.2
Change in fecal boli incidents, locomotor task	1.7	1.6	4.0	0.6	2.0	-1.6	0.6	0.9
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.1	0.4	-1.4	0.7	1.1	-0.4
Bouts of movement, locomotor time 1	1.8	2.0	3.3	-1.4	-0.9	1.4	-1.8	-1.2
Total resting periods, locomotor time 1	1.7	1.8	2.6	-1.3	-1.2	1.5	-1.6	-1.2
Rest time, locomotor task time 1	0.8	0.9	1.5	1.2	-0.1	-0.6	1.1	1.1
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.3	0.2	0.0	-0.2	-0.3
Vertical activity count, locomotor time 1	1.1	1.2	1.9	1.4	0.4	-1.1	1.1	1.3
Time >=10cm from walls, locomotor time 2	0.8	0.9	1.8	-0.5	-1.3	1.3	-0.1	-0.9
Bouts of movement, locomotor time 2	0.4	0.4	0.6	-0.8	-0.3	0.6	-0.8	-0.6
Total resting periods, locomotor time 2	0.2	0.2	0.3	-0.5	-0.3	0.5	-0.4	-0.4
Rest time, locomotor task time 2	2.0	2.3	4.8	1.8	0.1	-1.1	2.2	1.6
Distance moved, locomotor task time 2	1.0	1.1	2.2	-1.2	-0.2	0.8	-1.5	-1.1
Vertical activity count, locomotor time 2	0.6	0.7	1.4	0.4	1.2	-1.0	-0.3	0.8
Weight adjusted by age	2.9	3.3	5.1	-1.9	-1.0	1.7	-2.3	-1.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.2	0.4	0.4	-0.5	0.2	0.5
Locomotion in novel chamber	2.6	3.2	6.5	2.2	-1.4	-0.3	2.5	1.5
Locomotion in novel chamber post-restriction	2.2	2.6	5.6	2.0	-0.3	-1.0	2.4	1.6
Progressive ratio	2.1	2.4	4.3	-1.9	-0.8	1.6	-1.1	-2.1
Food seeking constrained by brief footshock	0.4	0.5	1.5	-0.1	1.2	-0.8	0.1	0.3
Seeking ratio, punishment vs. effort	3.5	4.3	6.1	2.0	1.9	-2.4	1.3	2.5
Run reversals in cocaine runway, females	1.1	1.1	4.0	-0.2	2.0	-1.2	-0.4	0.2
Run reversals in cocaine runway, males	0.3	0.3	0.4	0.6	0.3	-0.6	0.6	0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.1	-0.2	0.1	0.6	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	-0.5	0.4	0.0	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	0.3	0.1	-0.2	0.7	0.1
Cd content in liver	0.7	0.8	1.5	0.8	-1.2	0.3	1.2	0.5
Co content in liver	2.6	3.1	4.8	1.7	1.7	-2.1	0.9	2.2
Cu content in liver	0.2	0.2	0.4	-0.7	-0.2	0.5	-0.2	-0.6
Fe content in liver	0.3	0.3	0.6	-0.6	-0.4	0.5	-0.5	-0.8
K content in liver	1.0	1.0	1.8	-1.3	-0.0	0.7	-1.0	-1.3
Mg content in liver	0.0	0.0	0.1	-0.3	0.1	0.1	-0.1	-0.4
Mn content in liver	3.4	3.9	5.0	-2.1	-1.5	2.1	-1.8	-2.2
Na content in liver	1.4	1.5	1.9	-1.3	-0.9	1.4	-1.2	-1.4
Rb content in liver	1.4	1.8	2.6	1.5	0.6	-1.3	1.6	1.4
Se content in liver	1.2	1.5	3.7	-0.5	-1.9	1.5	0.4	-1.1
Sr content in liver	3.3	3.1	4.1	-2.0	-0.9	1.8	-2.0	-1.8
Zn content in liver	1.0	1.1	1.7	-1.3	-0.3	0.9	-1.0	-1.3