Hub : Traits

Bone: cortical porosity

Tags: Physiology · Bone

Project: r01_doug_adams

1 locus · 1 gene with independent associations · 21 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr10	89400319	91588067	21	1	2.48e-09	8.97e-09	3.98e-01	Marchf10

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Body weight	3.31	3	0	0	0.99	7.36e-05	Marchf10 Mettl2 Mrc2
Length with tail	2.85	2	0	0	0	1.00e+00	Marchf10 Mrc2
Extensor digitorum longus weight	3.79	1	0	0	0	1.00e+00	Marchf10
Pavlov. Cond. intertrial magazine entries	9.89	1	0	0	0	1.00e+00	Marchf10
Bone surface	7.6	4	0	0	1	1.59e-29	Cyb561 LOC120095188 Marchf10 Mrc2
Bone volume	6.94	2	0	0	0	1.00e+00	Cyb561 Marchf10
Bone: cortical apparent density	9.22	5	0	0	-1	2.34e-33	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: cortical porosity	22.41	5	0	0	1	2.06e-50	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: cortical tissue density	9.25	5	0	0	-1	8.10e-34	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: endosteal estimation	12.19	5	4	400	1	1.47e-33	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: endosteal perimeter	16.78	5	5	500	1	1.30e-33	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: marrow area	12.24	5	4	400	1	3.79e-34	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: maximum diameter	7.79	5	0	0	1	1.91e-39	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: minimum diameter	12.78	5	4	400	1	2.88e-33	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: periosteal estimation	10.82	5	2	200	1	1.95e-39	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2
Bone: periosteal perimeter	11.98	5	0	0	1	1.87e-40	Cyb561 LOC120095188 Marchf10 Mettl2 Mrc2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.06
Adipose	alternative TSS	0	0	1.1
Adipose	gene expression	0	0	1.12
Adipose	isoform ratio	0	0	1.09
Adipose	intron excision ratio	0	0	1
Adipose	mRNA stability	0	0	1.11
BLA	alternative polyA	0	0	1.23
BLA	alternative TSS	0	0	1.14
BLA	gene expression	1	0	1.1
BLA	isoform ratio	1	0	1.09
BLA	intron excision ratio	3	0.1	1.19
BLA	mRNA stability	0	0	1.09
Brain	alternative polyA	2	0.1	1.12
Brain	alternative TSS	0	0	1.07
Brain	gene expression	0	0	1.09
Brain	isoform ratio	1	0	1.06
Brain	intron excision ratio	3	0.1	1.13
Brain	mRNA stability	0	0	1.09
Eye	alternative polyA	0	0	1.04
Eye	alternative TSS	0	0	1.04
Eye	gene expression	0	0	1.11
Eye	isoform ratio	0	0	1.02
Eye	intron excision ratio	0	0	1.27
Eye	mRNA stability	0	0	1.05
IL	alternative polyA	0	0	1.12
IL	alternative TSS	0	0	1
IL	gene expression	0	0	1.08
IL	isoform ratio	1	0.1	0.99
IL	intron excision ratio	0	0	1.17
IL	mRNA stability	0	0	1.11
LHb	alternative polyA	0	0	1.18
LHb	alternative TSS	0	0	1.08
LHb	gene expression	0	0	1.06
LHb	isoform ratio	0	0	1.05
LHb	intron excision ratio	0	0	1.3
LHb	mRNA stability	0	0	1.1
Liver	alternative polyA	0	0	1.14
Liver	alternative TSS	0	0	1.1
Liver	gene expression	0	0	1.13
Liver	isoform ratio	0	0	1.06
Liver	intron excision ratio	2	0	1.15
Liver	mRNA stability	0	0	1.09
NAcc	alternative polyA	2	0.1	1.12
NAcc	alternative TSS	0	0	1.12
NAcc	gene expression	1	0	1.09
NAcc	isoform ratio	1	0	1.03
NAcc	intron excision ratio	2	0	1.11
NAcc	mRNA stability	0	0	1.06
OFC	alternative polyA	0	0	1.19
OFC	alternative TSS	0	0	1.07
OFC	gene expression	0	0	1.05
OFC	isoform ratio	1	0.1	1.11
OFC	intron excision ratio	0	0	1.09
OFC	mRNA stability	0	0	1.07
PL	alternative polyA	0	0	1.2
PL	alternative TSS	1	0	1.09
PL	gene expression	1	0	1.08
PL	isoform ratio	1	0	1.03
PL	intron excision ratio	2	0	1.07
PL	mRNA stability	0	0	1.07
pVTA	alternative polyA	0	0	1.07
pVTA	alternative TSS	0	0	1.17
pVTA	gene expression	0	0	1.1
pVTA	isoform ratio	1	0	0.99
pVTA	intron excision ratio	1	0	1.14
pVTA	mRNA stability	0	0	1.08
RMTg	alternative polyA	0	0	1.09
RMTg	alternative TSS	1	0.2	1.21
RMTg	gene expression	0	0	1.07
RMTg	isoform ratio	0	0	0.96
RMTg	intron excision ratio	0	0	1.13
RMTg	mRNA stability	1	0.2	1.18