Rbm14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression ENSRNOG00000045568 0.1 0.06 3.0e-09 0.08 0.11 0.11 0.05 3.2e-08 3.9e-10 2.5e-10 3.6e-05
2 Brain intron excision ratio chr1:202078683:202086011 0.03 0.02 3.9e-03 0.02 0.03 0.01 0.03 5.9e-03 1.5e-03 2.5e-02 1.3e-03
3 NAcc gene expression ENSRNOG00000045568 0.03 0.03 7.4e-03 0.02 0.01 0.01 0.02 1.2e-02 3.1e-02 3.0e-02 2.2e-02
4 PL gene expression ENSRNOG00000045568 0.06 0.04 3.3e-04 0.01 0.02 0.01 0.01 4.8e-02 1.8e-02 5.5e-02 5.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.82.65.42.30.60.82.0
BMI without tail0.20.40.80.90.50.10.8
Body weight0.93.69.6-0.23.1-2.0-0.8
Epididymis fat weight1.74.06.61.4-2.62.21.6
Glucose3.24.95.41.9-2.32.32.2
Heart weight1.62.33.71.2-1.61.91.3
Left kidney weight0.10.20.6-0.4-0.80.4-0.2
Right kidney weight0.10.20.5-0.4-0.0-0.2-0.7
Tail length2.36.98.5-2.62.3-2.9-2.7
Length with tail2.49.012.3-2.23.5-3.3-2.8
Length without tail1.22.65.5-0.62.3-1.8-1.2
Liver weight, left0.10.10.4-0.60.0-0.0-0.3
Liver weight, right0.10.20.4-0.6-0.1-0.3-0.4
Parametrial fat weight2.44.76.81.7-2.42.62.0
Retroperitoneal fat weight3.210.419.01.8-4.43.72.4
Intraocular pressure0.00.10.2-0.1-0.10.3-0.4
Extensor digitorum longus weight3.212.727.7-1.55.3-3.9-2.4
Soleus weight1.13.19.5-0.5-3.11.50.6
Tibialis anterior weight7.425.443.1-3.46.6-5.4-4.2
Tibia length0.71.82.4-1.11.5-1.4-1.3
Number of licking bursts0.00.00.10.20.2-0.10.1
Food consumed during 24 hour testing period0.10.10.2-0.50.0-0.2-0.4
Times rat made contact with spout0.10.10.20.40.3-0.10.3
Mean time between licks in bursts0.50.61.0-0.70.7-1.0-0.7
Mean num. licks in bursts0.10.10.20.3-0.40.40.4
Std. dev. time between licks in bursts1.21.42.5-1.60.8-1.0-1.3
Water consumed over 24 hours0.20.20.50.10.7-0.4-0.1
Indifference point 0 sec0.40.60.80.9-0.70.80.6
Indifference point AUC1.72.05.0-0.62.2-1.2-1.0
Indifference point function ln k2.02.98.8-0.1-3.01.50.7
Indifference point function log k2.02.98.8-0.1-3.01.50.7
Delay discounting total patch changes 0 sec0.00.00.10.1-0.30.2-0.0
Delay discounting total patch changes 12 sec1.01.44.40.22.1-0.9-0.5
Delay discounting total patch changes 18 sec0.20.30.60.80.70.20.3
Delay discounting total patch changes 24 sec1.21.52.9-0.61.7-1.3-1.1
Delay discounting total patch changes 6 sec0.20.30.90.50.9-0.20.2
Delay discounting time to switch 0 sec0.61.02.21.50.50.31.2
Delay discounting water rate 0 sec0.61.01.9-1.1-1.40.2-0.9
Delay discounting water rate 12 sec1.21.84.3-1.5-2.10.4-0.8
Delay discounting water rate 18 sec0.60.82.5-0.7-1.60.4-0.1
Delay discounting water rate 24 sec0.60.81.6-1.1-1.30.0-0.7
Delay discounting water rate 6 sec0.70.91.8-1.3-0.9-0.3-1.0
Locomotor activity0.30.50.7-0.8-0.9-0.1-0.8
Locomotor testing distance0.40.71.2-1.0-1.1-0.2-0.8
Locomotor testing rearing0.50.82.10.2-1.40.80.5
Light reinforcement 10.00.10.2-0.0-0.50.2-0.0
Light reinforcement 20.40.61.30.4-1.10.80.4
Reaction time number correct0.71.01.3-0.71.1-1.1-1.1
Reaction time mean minus median0.60.82.50.51.6-0.7-0.3
Reaction time mean minus median AUC1.11.43.1-0.31.8-1.2-1.0
Reaction time num false alarms0.81.11.9-1.40.4-1.0-1.2
Reaction time num false alarms AUC1.21.72.0-1.41.0-1.4-1.4
Reaction time trials correct on left0.71.01.3-0.71.1-1.1-1.1
Reaction time trials on left0.91.31.6-0.81.2-1.2-1.3
Reaction time mean0.00.00.10.3-0.10.10.2
Reaction time mean AUC0.10.10.20.5-0.20.20.4
Median of all reaction times0.10.20.30.4-0.50.30.4
Reaction time omissions0.91.22.5-0.31.6-1.2-0.9
Reaction time false alarm rate0.40.51.0-1.00.2-0.7-0.8
Reaction time premature initiation rate1.72.33.3-1.01.7-1.8-1.4
Reaction time premature initiations3.55.06.6-1.52.5-2.6-2.1
Std. dev. reaction times0.20.20.60.30.8-0.4-0.2
Reaction time trials completed0.91.31.6-0.81.2-1.2-1.3
Reaction time trials AUC0.70.91.2-0.61.0-1.0-1.1
Social response proportion0.20.20.60.80.10.10.5
Social responses0.10.20.2-0.30.4-0.5-0.3
Social time0.40.50.7-0.80.7-0.8-0.6
Conditioned locomotion2.42.84.1-1.32.0-1.7-1.6
Cocaine response after cond. corrected0.20.20.5-0.0-0.70.50.1
Cocaine response after cond. not corrected0.30.40.80.3-0.90.60.4
Cocaine response before conditioning0.10.10.20.50.20.00.4
Saline control response0.81.12.6-0.31.6-1.2-0.5
Condit. Reinf. active minus inactive responses1.41.82.01.4-1.21.31.3
Condit. Reinf. active-inactive response ratio1.61.72.31.1-1.51.41.2
Condit. Reinf. active responses1.62.23.41.9-0.91.31.7
Condit. Reinf. inactive responses0.70.91.81.30.00.71.1
Condit. Reinf. lever presses0.30.40.90.70.9-0.20.4
Condit. Reinf. lever reinforcers received1.11.62.81.7-0.61.11.5
Pavlov. Cond. lever latency0.10.10.3-0.2-0.50.0-0.1
Pavlov. Cond. magazine entry latency0.50.51.30.81.1-0.50.3
Pavlov. Cond. change in total contacts0.40.61.41.20.50.30.8
Pavlov. Cond. index score0.20.30.70.60.9-0.30.3
Pavlov. Cond. latency score0.20.20.60.50.8-0.30.3
Pavlov. Cond. lever contacts0.10.20.4-0.30.6-0.4-0.2
Pavlov. Cond. magazine entry number0.81.02.7-0.8-1.60.8-0.2
Pavlov. Cond. intertrial magazine entries0.30.30.90.1-0.90.60.3
Pavlov. Cond. lever-magazine prob. diff.0.30.41.00.61.0-0.40.3
Pavlov. Cond. response bias0.20.30.80.30.9-0.30.1
Conditioned reinforcement - actives0.00.00.1-0.1-0.40.1-0.1
Conditioned reinforcement - inactives2.52.95.60.8-2.42.01.1
Conditioned locomotion1.82.26.4-0.3-2.51.50.4
Intermittent access intake day 1-15 change0.10.10.3-0.5-0.10.0-0.5
Intermittent access intake escalation0.10.10.1-0.2-0.30.3-0.2
Intermittent access intake escalation 20.30.30.5-0.60.1-0.3-0.7
Intermitt. access day 1 inactive lever presses1.31.52.20.8-1.41.51.0
Intermitt. access day 15 inactive lever presses1.31.42.10.9-1.41.40.9
Intermitt. access escalation Index2.72.44.10.8-2.01.71.4
Intermittent access day 1 total infusions9.010.212.22.7-3.33.53.2
Intermittent access day 15 total infusions5.66.39.51.7-3.12.92.1
Intermittent access terminal intake (last 3 days)5.25.67.31.8-2.72.72.1
Intermittent access total infusions6.37.08.62.3-2.82.92.6
Intermittent access day 1 locomotion6.97.07.72.5-2.62.82.7
Intermittent access day 15 total locomotion4.04.35.91.6-2.42.31.9
Intermittent access total locomotion9.510.712.72.8-3.53.63.2
Intermittent access standard deviation0.10.10.3-0.0-0.50.50.0
Cocaine induced anxiety0.10.10.1-0.30.2-0.2-0.3
Post-drug Anxiety1.51.72.4-1.01.5-1.3-1.2
Baseline Anxiety1.92.03.1-1.01.8-1.5-1.2
Lifetime Intake5.76.47.92.2-2.62.82.5
Incentive Sensitization - Responses0.80.80.90.9-0.81.00.9
Incentive Sensitization - Breakpoint0.80.81.00.9-0.91.00.9
Progressive ratio test 1 active lever presses1.81.93.10.9-1.81.51.2
Progressive ratio test 1 breakpoint1.31.42.50.7-1.61.30.9
Progressive ratio test 1 inactive lever presses1.11.21.70.8-1.31.21.0
Progressive ratio test 2 active lever presses3.23.45.31.4-2.32.01.6
Progressive ratio test 2 breakpoint2.52.85.41.0-2.31.81.2
Progressive ratio test 2 inactive lever presses6.98.012.32.0-3.53.12.4
Total sessions with >9 infusions1.92.02.51.2-1.51.61.4
Short access day 1 total inactive lever presses2.42.74.50.9-2.11.91.4
Short access day 10 total inactive lever presses0.70.82.00.2-1.41.00.5
Short access day 1 total infusions4.95.36.31.9-2.42.52.3
Short access day 10 total infusions6.67.28.92.8-2.12.83.0
Short access total infusions3.23.64.21.8-1.72.02.0
Short access day 1 locomotion4.64.95.52.0-2.22.32.2
Short access day 10 total locomotion3.84.24.81.9-1.92.22.1
Short access total locomotion3.63.64.01.9-1.82.02.0
Compulsive drug intake3.53.54.9-1.62.0-2.2-1.7
One hour access (0.3 mA shock)5.05.910.61.3-3.32.81.9
One hour access (shock baseline)5.96.810.21.7-3.23.12.1
Number of responses in last shaping day0.10.10.5-0.1-0.70.2-0.0
Context. condit. distance diff. score0.70.81.80.3-1.31.00.6
Locomotion velocity, session 10.40.50.7-0.80.3-0.8-0.7
Locomotion distance, session 10.40.61.21.1-0.20.31.0
Locomotion velocity, session 20.70.82.3-0.11.5-0.9-0.4
Locomotion distance, session 20.10.10.20.40.4-0.20.4
Locomotion velocity, session 30.40.40.50.7-0.60.60.7
Locomotion distance, session 30.00.00.00.1-0.00.10.1
Stereotopy head waving bouts, day 30.70.81.10.6-1.11.00.9
Stereotopy head waving duration, day 31.11.32.00.8-1.41.21.1
Locomotion velocity, session 71.11.21.51.1-0.81.21.1
Locomotion distance, session 70.00.00.00.20.10.10.2
Stereotopy head waving bouts, day 71.31.51.81.3-0.81.41.3
Stereotopy head waving duration, day 70.91.12.21.50.20.81.2
Locomotion velocity, session 80.91.11.5-0.71.2-1.2-0.9
Locomotion distance, session 80.30.40.60.5-0.80.50.6
Degree of sensitization distance0.10.10.20.4-0.20.30.5
Degree of sensitization stereotypy0.50.51.11.10.40.60.7
Condit. Reinf. active minus inactive responses0.10.10.20.5-0.10.10.4
Condit. Reinf. active-inactive response ratio0.10.20.30.5-0.40.20.4
Condit. Reinf. active responses0.00.00.10.30.0-0.00.2
Condit. Reinf. inactive responses0.00.00.00.20.00.20.2
Incentive salience index mean0.10.10.30.50.10.00.4
Condit. Reinf. lever presses0.10.10.2-0.00.5-0.3-0.1
Time in familiar zone, hab. session 11.00.91.11.0-1.00.90.9
Time in novel zone, hab. session 10.60.61.3-1.10.3-0.6-0.8
Total zone transitions, hab. session 10.20.20.50.10.7-0.7-0.1
Total locomotion distance, hab. session 10.20.30.50.3-0.70.50.5
Locomotion velocity, hab. session 10.00.00.10.2-0.20.20.3
Time in familiar zone, hab. session 20.70.81.1-1.10.7-0.8-0.9
Time in novel zone, hab. session 20.80.81.41.2-0.50.81.0
Total zone transitions, hab. session 21.92.55.42.3-0.11.11.9
Total locomotion distance, hab. session 21.31.72.41.6-0.81.21.5
Locomotion velocity, hab. session 21.62.12.81.7-1.11.31.6
Novel to familiar place preference ratio0.40.40.90.90.30.40.6
Novelty place preference0.50.61.11.0-0.10.70.8
Time in novel zone, NPP test0.50.50.90.9-0.10.70.8
Total zone transitions, NPP test0.20.30.60.60.8-0.50.3
Total locomotion distance, NPP test0.10.10.20.4-0.30.10.4
Locomotion velocity, NPP test0.00.10.10.3-0.20.00.4
Pavlov. Cond. lever latency0.00.10.1-0.2-0.40.0-0.1
Pavlov. Cond. magazine entry latency1.11.42.61.6-0.51.11.3
Pavlov. Cond. change in total contacts0.70.71.21.1-0.60.80.8
Pavlov. Cond. index score0.10.10.20.40.10.20.2
Pavlov. Cond. latency score0.10.10.30.5-0.00.30.4
Pavlov. Cond. lever contacts0.00.00.00.10.10.10.1
Pavlov. Cond. magazine entry number0.00.00.1-0.3-0.3-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.3-0.10.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.40.20.10.2
Pavlov. Cond. response bias0.00.00.10.30.20.00.0
Bone: apparent density1.72.94.42.1-0.51.62.1
Bone surface1.01.83.82.01.10.51.4
Bone volume1.22.14.02.00.11.21.8
Bone: connectivity density1.21.94.02.00.50.91.6
Bone: cortical apparent density0.30.40.5-0.40.7-0.7-0.7
Bone: cortical area0.71.11.8-0.91.3-1.0-1.0
Bone: cortical porosity0.30.40.70.6-0.40.50.8
Bone: cortical porosity0.10.10.20.30.30.10.4
Bone: cortical thickness5.18.411.4-2.53.4-2.9-2.8
Bone: cortical thickness3.13.74.0-1.81.9-2.0-2.0
Bone: cortical tissue density0.40.60.7-0.50.8-0.8-0.8
Bone: elastic displacement1.31.52.8-1.70.3-0.9-1.5
Bone: elastic work2.63.43.7-1.81.8-1.9-1.9
Bone: endosteal estimation2.24.65.21.9-2.32.22.2
Bone: endosteal perimeter4.08.39.22.7-3.02.82.9
Bone: final force0.71.12.8-0.31.7-1.1-0.5
Bone: final moment0.60.92.4-0.31.6-1.0-0.5
Bone: marrow area2.24.85.31.9-2.32.22.2
Bone: maximum diameter0.00.00.00.00.1-0.0-0.0
Bone: maximum force0.40.81.41.21.1-0.20.6
Bone: maximum moment0.40.71.21.11.0-0.20.6
Bone: minimum diameter2.95.46.12.3-2.12.52.5
Bone: periosteal estimation0.10.30.40.5-0.40.60.6
Bone: periosteal perimeter0.30.60.80.9-0.40.70.9
Bone: post-yield work8.211.218.04.2-1.93.03.8
Bone: stiffness0.61.02.41.60.70.31.0
Bone: tissue strength0.30.30.50.7-0.30.40.6
Bone: trabecular number1.62.44.02.0-0.21.41.9
Bone: trabecular spacing0.20.20.4-0.6-0.2-0.5-0.6
Bone: trabecular thickness2.02.43.01.4-1.31.71.7
Bone: trabecular tissue density0.81.13.5-0.4-1.90.90.1
Breakpoint value in progressive ratio session1.01.12.5-0.31.6-1.2-0.6
Distance traveled before self-admin0.00.00.20.10.4-0.1-0.1
Distance traveled after self-admin0.00.00.10.20.3-0.10.0
Delta time in closed arm before/after self-admin0.80.71.2-0.81.1-0.7-0.8
Delta time in open arm before/after self-admin0.00.00.00.10.1-0.1-0.0
Diff in mean of infusions in LGA sessions0.50.50.9-0.31.0-0.7-0.7
Extinction: sum of active levers before priming0.70.72.00.41.4-0.8-0.1
Active lever presses in extinction session 62.52.43.9-1.12.0-1.6-1.4
Delta distance traveled before/after self-admin0.00.00.0-0.10.0-0.1-0.1
Delta ambulatory time before/after self-admin0.10.10.1-0.20.2-0.2-0.3
Time in closed arm before self-admin0.30.30.60.8-0.50.30.6
Time in closed arm after self-admin0.00.00.10.30.20.00.0
Time in open arm before self-admin0.10.10.4-0.6-0.2-0.1-0.3
Time in open arm after self-admin0.20.20.5-0.70.1-0.4-0.5
Sum of active levers in priming session hrs 5-62.22.22.8-1.11.6-1.5-1.7
Time to tail flick, vehicle, before self-admin0.20.20.50.70.30.10.4
Time to tail flick, vehicle, after self-admin0.30.41.00.21.0-0.60.1
Time to tail flick, test, before self-admin1.21.21.51.0-1.10.91.2
Time to tail flick, test, after self-admin0.00.00.10.00.2-0.3-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.30.10.5-0.30.1
Delta time to tail flick, test, before/after SA3.22.93.3-1.51.8-1.7-1.8
Ambulatory time before self-admin0.10.10.30.60.30.20.2
Ambulatory time after self-admin1.11.31.71.3-0.81.21.2
Total heroin consumption1.61.94.1-0.32.0-1.5-1.1
Area under the delay curve1.01.11.60.9-1.21.01.1
Delay disc. indifference point, 0s delay0.80.91.50.5-1.21.00.9
Delay disc. indifference point, 16s delay2.72.73.31.5-1.81.71.5
Delay disc. indifference point, 2s delay0.20.30.60.2-0.80.40.5
Delay disc. indifference point, 24s delay0.10.10.2-0.3-0.1-0.1-0.4
Delay disc. indifference point, 4s delay0.40.40.70.4-0.90.60.6
Delay disc. indifference point, 8s delay0.30.30.60.3-0.80.40.5
Delay discount exponential model param0.70.81.2-0.71.1-0.8-0.9
Delay discount hyperbolic model param0.60.61.0-0.61.0-0.7-0.8
Fecal boli incidents, locomotor time 10.20.20.40.60.40.50.1
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.40.20.3
Time >=10cm from walls, locomotor time 14.54.55.02.2-1.92.12.2
Bouts of movement, locomotor time 10.30.30.90.01.0-0.5-0.3
Total resting periods, locomotor time 10.10.10.40.40.7-0.1-0.0
Rest time, locomotor task time 10.30.31.0-0.2-1.00.50.0
Distance moved, locomotor task time 10.30.30.70.7-0.10.50.8
Vertical activity count, locomotor time 10.30.30.70.1-0.80.70.3
Time >=10cm from walls, locomotor time 20.20.20.30.5-0.50.30.4
Bouts of movement, locomotor time 20.10.20.50.20.7-0.3-0.1
Total resting periods, locomotor time 20.10.10.20.40.40.00.2
Rest time, locomotor task time 20.91.02.40.3-1.51.10.6
Distance moved, locomotor task time 20.50.60.9-0.60.9-0.8-0.6
Vertical activity count, locomotor time 21.71.92.8-1.70.8-1.2-1.6
Weight adjusted by age1.51.63.3-0.61.8-1.4-1.0
Seeking ratio, delayed vs. immediate footshock0.50.60.90.8-0.70.61.0
Locomotion in novel chamber2.32.86.40.7-2.51.81.1
Locomotion in novel chamber post-restriction1.01.12.60.3-1.61.20.6
Progressive ratio1.01.22.31.50.30.61.4
Food seeking constrained by brief footshock0.40.50.8-0.50.8-0.9-0.6
Seeking ratio, punishment vs. effort0.91.22.3-1.5-0.3-0.8-1.3
Run reversals in cocaine runway, females0.20.20.40.60.20.00.6
Run reversals in cocaine runway, males2.62.53.3-1.81.0-1.5-1.8
Latency to leave start box in cocaine runway1.01.11.81.3-0.70.81.2
Latency to leave start box in cocaine runway, F0.40.50.70.9-0.50.50.8
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.20.10.3
Cd content in liver0.20.20.6-0.2-0.80.5-0.0
Co content in liver1.11.33.1-1.7-0.1-0.8-1.2
Cu content in liver0.00.00.1-0.10.3-0.10.1
Fe content in liver0.10.20.2-0.30.5-0.3-0.4
K content in liver0.30.30.70.80.5-0.10.7
Mg content in liver2.62.74.12.0-0.91.42.0
Mn content in liver0.60.71.70.71.3-0.6-0.2
Na content in liver0.80.91.3-0.80.8-1.1-1.0
Rb content in liver2.22.73.41.3-1.71.81.8
Se content in liver1.11.32.01.4-0.61.21.2
Sr content in liver2.72.53.7-1.21.9-1.6-1.5
Zn content in liver0.20.20.6-0.00.8-0.5-0.2