Hub : Genes

Tm7sf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000020989 0.16 0.07 4.4e-16 0.09 0.11 0.11 0.11 4.0e-10 2.5e-12 2.8e-12 7.9e-12
2 Adipose mRNA stability ENSRNOG00000020989 0.03 0.02 9.0e-03 0.01 0 0 0 2.8e-02 8.2e-02 3.5e-01 1.5e-01
3 BLA gene expression ENSRNOG00000020989 0.26 0.1 5.6e-17 0.32 0.3 0.31 0.31 6.2e-18 1.7e-16 5.6e-17 4.7e-17
4 Brain gene expression ENSRNOG00000020989 0.33 0.15 0.0e+00 0.3 0.32 0.32 0.32 1.6e-28 3.8e-30 2.4e-30 2.5e-30
5 Brain mRNA stability ENSRNOG00000020989 0.06 0.03 3.2e-06 0.06 0.04 0.04 0.05 5.6e-06 6.2e-05 1.0e-04 2.0e-05
6 IL gene expression ENSRNOG00000020989 0.22 0.12 5.3e-04 0.1 0.1 0.12 0.14 1.9e-03 2.7e-03 7.5e-04 2.8e-04
7 LHb gene expression ENSRNOG00000020989 0.2 0.11 9.4e-04 0.1 0.14 0.09 0.09 2.2e-03 2.7e-04 4.3e-03 3.7e-03
8 Liver gene expression ENSRNOG00000020989 0.19 0.09 1.1e-16 0.11 0.1 0.1 0.11 1.4e-12 4.0e-11 4.6e-11 5.3e-12
9 NAcc gene expression ENSRNOG00000020989 0.18 0.1 1.8e-09 0.12 0.09 0.09 0.1 5.9e-09 2.9e-07 1.9e-07 9.4e-08
10 NAcc mRNA stability ENSRNOG00000020989 0.08 0.05 1.3e-05 0.06 0.06 0.06 0.06 5.6e-05 4.9e-05 2.5e-05 2.3e-05
11 OFC gene expression ENSRNOG00000020989 0.21 0.1 9.9e-05 0.19 0.18 0.16 0.18 2.8e-05 4.8e-05 9.9e-05 5.0e-05
12 PL gene expression ENSRNOG00000020989 0.2 0.11 7.4e-15 0.21 0.19 0.2 0.2 6.5e-16 1.9e-14 5.3e-15 5.4e-15
13 PL mRNA stability ENSRNOG00000020989 0.12 0.08 1.1e-06 0.06 0.07 0.06 0.06 1.8e-05 6.2e-06 1.3e-05 2.5e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail2.68.416.20.31.2-3.0-3.6-2.7-3.6-3.7-3.1-2.8-4.0-3.0-2.8-1.3
BMI without tail1.42.96.10.00.6-1.6-1.9-1.7-2.3-2.2-1.5-1.7-2.5-1.6-1.9-1.2
Body weight3.715.821.6-2.4-1.7-4.2-4.6-4.0-4.3-4.6-4.3-4.2-4.6-4.3-4.0-3.1
Epididymis fat weight2.86.68.82.62.42.72.52.72.42.42.72.52.42.72.53.0
Glucose2.23.45.62.42.21.81.42.01.61.51.81.81.31.81.92.2
Heart weight3.65.16.32.21.72.52.12.52.32.22.42.32.12.52.42.0
Left kidney weight0.71.92.91.31.31.41.71.31.31.41.41.31.41.31.31.6
Right kidney weight0.20.41.30.30.40.50.90.50.70.70.50.31.00.50.61.1
Tail length1.03.06.8-2.5-2.6-1.4-1.3-1.8-1.4-1.3-1.2-1.5-1.2-1.4-1.8-2.2
Length with tail2.38.610.9-3.3-3.1-3.0-2.9-2.9-2.6-2.8-2.9-3.0-2.6-3.0-2.9-2.9
Length without tail2.34.97.3-2.1-2.0-2.5-2.6-2.0-1.8-2.3-2.7-2.3-2.1-2.5-1.8-1.8
Liver weight, left0.10.10.30.30.20.30.60.20.20.10.20.30.00.20.20.4
Liver weight, right0.00.10.20.1-0.20.30.50.20.1-0.10.30.4-0.40.30.10.2
Parametrial fat weight2.54.98.42.92.82.12.12.21.61.82.12.21.52.12.02.7
Retroperitoneal fat weight6.019.822.34.43.74.54.74.64.44.34.54.64.24.54.64.7
Intraocular pressure0.91.23.20.20.21.10.51.21.31.41.11.01.81.11.11.3
Extensor digitorum longus weight7.730.837.9-4.1-3.0-5.9-6.2-5.8-5.9-6.1-5.8-5.8-6.2-5.9-5.8-4.8
Soleus weight4.212.114.13.02.33.73.53.73.73.53.73.73.33.73.83.3
Tibialis anterior weight11.339.044.3-5.7-4.7-6.5-6.7-6.5-6.2-6.5-6.5-6.6-6.3-6.5-6.5-5.5
Tibia length0.92.64.0-1.6-1.0-1.8-2.0-1.9-1.6-1.6-1.8-1.8-1.1-1.8-1.9-0.5
Number of licking bursts0.30.30.5-0.4-0.2-0.7-0.6-0.7-0.5-0.5-0.7-0.6-0.4-0.7-0.5-0.3
Food consumed during 24 hour testing period0.10.10.4-0.7-0.6-0.20.0-0.30.00.1-0.2-0.30.5-0.2-0.2-0.1
Times rat made contact with spout0.50.51.3-0.6-0.5-0.7-0.6-0.7-0.8-0.6-0.7-0.7-0.7-0.7-0.7-1.2
Mean time between licks in bursts0.71.02.4-1.2-1.5-1.0-1.0-0.5-0.7-1.0-1.0-0.8-1.0-1.0-0.7-1.4
Mean num. licks in bursts0.20.20.40.30.10.60.50.50.40.50.60.50.30.60.4-0.1
Std. dev. time between licks in bursts0.10.10.9-0.4-0.90.1-0.10.50.40.10.10.2-0.00.10.4-0.5
Water consumed over 24 hours0.91.02.2-1.2-1.1-1.0-0.8-1.0-0.9-0.7-1.0-1.1-0.7-1.0-1.1-1.5
Indifference point 0 sec0.00.10.20.30.30.10.40.10.30.3-0.00.20.30.10.30.2
Indifference point AUC3.54.15.4-1.9-1.5-2.2-1.7-2.2-2.2-1.9-2.2-2.3-1.8-2.2-2.3-1.7
Indifference point function ln k8.211.615.13.02.13.83.53.73.73.43.73.92.93.83.82.7
Indifference point function log k8.211.615.13.02.13.83.53.73.73.43.73.92.93.83.82.7
Delay discounting total patch changes 0 sec0.00.00.1-0.1-0.20.00.30.00.30.2-0.10.10.20.00.3-0.1
Delay discounting total patch changes 12 sec4.76.28.1-1.9-1.4-2.8-2.4-2.7-2.7-2.5-2.8-2.8-2.4-2.8-2.6-2.2
Delay discounting total patch changes 18 sec0.60.71.2-0.4-0.1-1.0-0.8-1.0-1.1-0.9-1.0-1.1-0.8-1.0-1.0-0.4
Delay discounting total patch changes 24 sec2.73.44.6-2.0-1.8-2.0-1.6-1.9-1.6-1.7-1.9-2.1-1.6-2.0-1.8-1.7
Delay discounting total patch changes 6 sec0.91.32.2-0.8-0.8-1.4-0.8-1.1-1.1-1.2-1.5-1.3-1.2-1.4-1.1-1.1
Delay discounting time to switch 0 sec1.62.53.9-0.00.7-1.7-1.8-1.7-2.0-1.9-1.8-1.6-1.8-1.8-1.6-0.6
Delay discounting water rate 0 sec3.96.19.30.90.02.63.02.73.12.92.72.62.72.62.71.8
Delay discounting water rate 12 sec7.811.616.41.50.23.93.93.74.03.84.03.83.43.93.62.2
Delay discounting water rate 18 sec2.93.95.51.20.32.22.22.22.32.02.32.21.72.32.11.4
Delay discounting water rate 24 sec3.85.37.51.10.32.72.52.52.72.42.72.42.22.72.51.7
Delay discounting water rate 6 sec3.65.28.41.0-0.22.62.32.72.92.42.62.52.12.62.61.4
Locomotor activity1.62.54.00.6-0.21.91.71.82.01.81.71.71.61.91.90.9
Locomotor testing distance2.33.85.70.6-0.42.42.22.12.42.12.22.11.82.42.30.9
Locomotor testing rearing2.03.14.60.80.12.22.01.92.01.92.12.01.62.12.00.9
Light reinforcement 10.10.20.4-0.1-0.30.40.60.30.50.60.50.30.60.50.3-0.0
Light reinforcement 21.01.32.70.80.81.21.10.91.21.21.31.01.31.21.01.6
Reaction time number correct0.40.51.3-1.1-1.2-0.6-0.8-0.4-0.5-0.7-0.5-0.8-0.7-0.6-0.6-0.7
Reaction time mean minus median2.93.85.8-1.4-0.7-2.1-2.4-2.0-2.2-2.1-2.2-2.1-1.8-2.2-2.1-1.3
Reaction time mean minus median AUC1.62.03.2-1.3-0.9-1.5-1.8-1.4-1.5-1.5-1.5-1.6-1.2-1.5-1.5-1.0
Reaction time num false alarms0.20.30.70.2-0.50.40.60.80.80.50.40.70.30.40.8-0.2
Reaction time num false alarms AUC0.10.10.6-0.3-0.8-0.2-0.10.10.1-0.2-0.3-0.0-0.4-0.20.1-0.8
Reaction time trials correct on left0.40.51.3-1.1-1.2-0.6-0.8-0.4-0.5-0.7-0.5-0.8-0.7-0.6-0.6-0.7
Reaction time trials on left0.50.71.6-1.2-1.3-0.7-0.9-0.5-0.6-0.8-0.6-0.9-0.8-0.7-0.7-0.8
Reaction time mean0.00.00.2-0.10.1-0.4-0.20.1-0.10.0-0.2-0.30.2-0.4-0.10.1
Reaction time mean AUC0.00.00.10.10.4-0.3-0.20.1-0.10.1-0.2-0.20.2-0.30.00.2
Median of all reaction times0.10.10.30.40.50.00.30.50.30.40.30.20.60.00.40.4
Reaction time omissions1.11.52.9-1.0-0.6-1.3-1.7-1.0-1.1-1.2-1.3-1.3-1.2-1.3-1.1-1.2
Reaction time false alarm rate0.20.20.40.4-0.00.40.60.60.60.40.30.70.30.40.7-0.0
Reaction time premature initiation rate3.14.26.7-2.2-2.4-1.9-1.8-1.8-1.8-2.0-1.9-1.9-2.4-1.9-1.9-2.6
Reaction time premature initiations4.86.810.1-3.0-3.2-2.4-2.4-2.3-2.3-2.5-2.4-2.5-2.7-2.4-2.5-3.2
Std. dev. reaction times0.71.01.5-0.8-0.4-1.2-1.2-0.9-1.1-0.9-1.2-1.2-0.7-1.2-1.0-0.6
Reaction time trials completed0.50.71.6-1.2-1.3-0.7-0.9-0.5-0.6-0.8-0.6-0.9-0.8-0.7-0.7-0.8
Reaction time trials AUC0.30.41.2-1.0-1.1-0.5-0.7-0.3-0.4-0.6-0.4-0.6-0.6-0.5-0.5-0.7
Social response proportion0.91.01.8-0.8-0.7-1.1-1.3-0.9-1.1-1.0-1.3-1.1-0.7-1.1-1.0-0.7
Social responses0.30.41.2-0.9-1.1-0.7-0.8-0.5-0.5-0.5-0.7-0.4-0.3-0.6-0.7-0.7
Social time0.40.61.3-1.1-1.2-0.6-0.9-0.4-0.6-0.8-0.6-0.7-0.6-0.6-0.7-0.9
Conditioned locomotion1.82.12.5-1.3-1.2-1.6-1.6-1.3-1.3-1.6-1.5-1.4-1.6-1.5-1.4-1.3
Cocaine response after cond. corrected1.41.62.51.10.51.51.31.61.41.11.51.40.81.51.40.9
Cocaine response after cond. not corrected1.01.21.90.90.51.31.01.41.20.91.31.20.61.31.20.9
Cocaine response before conditioning0.70.81.3-0.7-0.2-1.0-1.1-1.0-1.0-0.8-1.0-1.1-0.7-1.0-1.0-0.5
Saline control response4.56.07.9-2.1-1.9-2.6-2.8-2.4-2.5-2.6-2.6-2.4-2.5-2.6-2.5-2.3
Condit. Reinf. active minus inactive responses0.20.30.80.60.90.40.40.50.40.50.40.50.30.40.40.8
Condit. Reinf. active-inactive response ratio1.01.13.31.31.50.90.60.90.80.80.91.00.60.90.91.8
Condit. Reinf. active responses0.00.10.40.30.6-0.1-0.2-0.1-0.2-0.0-0.20.0-0.1-0.2-0.10.1
Condit. Reinf. inactive responses0.30.41.2-0.3-0.2-0.6-0.6-0.6-0.7-0.5-0.6-0.6-0.6-0.6-0.6-1.1
Condit. Reinf. lever presses1.82.53.3-1.1-0.6-1.8-1.8-1.7-1.7-1.7-1.8-1.8-1.4-1.8-1.7-0.9
Condit. Reinf. lever reinforcers received0.10.20.3-0.10.3-0.5-0.6-0.5-0.5-0.4-0.6-0.4-0.4-0.6-0.5-0.3
Pavlov. Cond. lever latency0.40.50.90.40.10.80.90.70.80.90.80.90.70.80.80.1
Pavlov. Cond. magazine entry latency3.43.95.8-1.3-0.6-2.1-2.0-2.2-2.4-2.1-2.1-2.0-2.0-2.1-2.3-1.7
Pavlov. Cond. change in total contacts1.42.03.1-0.70.2-1.6-1.6-1.6-1.8-1.4-1.6-1.6-1.1-1.6-1.7-0.6
Pavlov. Cond. index score2.12.73.9-1.0-0.3-1.9-1.8-1.9-2.0-1.8-1.8-1.8-1.5-1.8-1.9-1.0
Pavlov. Cond. latency score1.72.13.1-0.8-0.1-1.6-1.6-1.6-1.8-1.6-1.6-1.6-1.4-1.6-1.7-0.8
Pavlov. Cond. lever contacts0.40.60.8-0.8-0.6-0.9-0.8-0.8-0.7-0.8-0.9-0.9-0.5-0.9-0.8-0.3
Pavlov. Cond. magazine entry number5.97.39.92.01.03.02.73.03.22.83.02.82.53.03.02.3
Pavlov. Cond. intertrial magazine entries1.11.41.81.00.81.31.01.21.41.21.41.11.11.41.31.3
Pavlov. Cond. lever-magazine prob. diff.2.63.44.8-1.2-0.4-2.0-1.9-2.1-2.2-2.0-2.0-2.0-1.7-2.0-2.1-1.3
Pavlov. Cond. response bias1.62.22.9-1.2-0.7-1.7-1.5-1.6-1.7-1.5-1.7-1.7-1.3-1.7-1.7-1.0
Conditioned reinforcement - actives0.30.30.90.10.10.60.10.40.60.60.60.50.70.60.51.0
Conditioned reinforcement - inactives6.67.510.22.12.02.72.72.82.83.12.62.93.22.82.62.9
Conditioned locomotion8.710.413.72.21.63.33.13.33.73.63.43.33.63.43.53.2
Intermittent access intake day 1-15 change0.70.71.40.1-0.00.90.60.90.91.10.80.81.20.80.81.0
Intermittent access intake escalation0.60.61.10.30.30.80.60.80.81.00.80.81.00.80.71.0
Intermittent access intake escalation 20.20.20.5-0.3-0.30.40.30.40.50.70.40.40.70.30.30.5
Intermitt. access day 1 inactive lever presses2.72.93.81.51.51.71.61.71.71.91.61.81.91.71.71.7
Intermitt. access day 15 inactive lever presses3.13.55.11.61.51.81.51.92.02.01.71.92.21.81.92.2
Intermitt. access escalation Index3.53.24.72.11.91.82.21.81.41.61.91.81.52.01.61.4
Intermittent access day 1 total infusions6.97.812.33.53.52.72.42.62.52.32.82.62.12.72.83.4
Intermittent access day 15 total infusions9.610.715.13.22.93.33.03.33.33.23.43.33.13.33.33.9
Intermittent access terminal intake (last 3 days)6.97.512.72.92.82.72.42.72.62.62.82.72.52.72.73.6
Intermittent access total infusions6.16.710.93.03.02.52.22.52.32.32.62.42.12.62.63.3
Intermittent access day 1 locomotion4.84.99.13.02.92.11.62.11.91.72.32.11.52.22.22.5
Intermittent access day 15 total locomotion5.96.28.82.52.52.52.02.52.42.52.52.52.42.52.53.0
Intermittent access total locomotion7.88.814.23.63.72.82.42.92.62.62.92.82.42.92.93.8
Intermittent access standard deviation1.41.42.10.70.51.30.71.21.41.41.41.21.41.31.31.3
Cocaine induced anxiety0.00.00.1-0.1-0.1-0.0-0.1-0.1-0.1-0.10.1-0.0-0.1-0.0-0.20.3
Post-drug Anxiety1.41.63.5-1.4-1.3-1.3-1.9-1.2-1.0-1.2-1.3-1.2-1.1-1.3-1.1-0.7
Baseline Anxiety2.83.05.4-1.7-1.6-1.8-2.3-1.6-1.5-1.7-1.9-1.6-1.6-1.8-1.5-1.7
Lifetime Intake5.35.99.12.92.92.32.02.32.22.12.42.31.92.42.43.0
Incentive Sensitization - Responses0.70.71.50.91.00.70.80.80.80.80.80.80.90.70.81.2
Incentive Sensitization - Breakpoint1.11.12.01.01.10.91.01.01.01.01.01.01.10.91.01.4
Progressive ratio test 1 active lever presses3.73.94.51.71.52.02.11.92.12.02.11.92.02.02.02.0
Progressive ratio test 1 breakpoint3.43.54.41.51.21.92.11.82.01.92.01.81.91.91.91.9
Progressive ratio test 1 inactive lever presses1.51.62.11.21.11.41.41.21.31.41.31.31.31.31.31.0
Progressive ratio test 2 active lever presses5.65.98.32.22.12.42.52.42.52.52.52.42.42.42.52.9
Progressive ratio test 2 breakpoint6.77.58.72.21.92.73.02.82.92.92.92.72.92.72.83.0
Progressive ratio test 2 inactive lever presses10.311.914.63.33.13.53.23.43.43.63.43.43.63.53.53.8
Total sessions with >9 infusions2.22.44.02.01.81.61.41.61.61.21.51.51.01.51.71.8
Short access day 1 total inactive lever presses4.44.96.42.32.02.21.92.42.42.32.12.32.12.22.52.2
Short access day 10 total inactive lever presses3.64.05.01.71.22.12.02.22.22.22.02.22.12.12.21.5
Short access day 1 total infusions3.84.07.22.72.71.91.81.81.81.62.01.81.41.92.02.2
Short access day 10 total infusions2.62.88.62.72.91.51.11.41.21.01.51.40.71.41.52.2
Short access total infusions2.02.24.72.22.21.31.11.31.21.01.51.30.71.41.51.8
Short access day 1 locomotion3.03.25.72.42.31.81.31.71.51.41.81.81.01.81.82.0
Short access day 10 total locomotion2.32.54.92.22.21.71.11.51.21.21.61.51.01.51.41.7
Short access total locomotion1.92.04.22.02.01.31.01.31.21.01.51.30.71.41.41.5
Compulsive drug intake3.33.27.1-2.1-2.2-1.7-0.9-1.7-1.6-1.6-1.7-1.7-1.5-1.7-1.8-2.7
One hour access (0.3 mA shock)11.613.515.83.22.73.83.73.83.73.83.93.73.63.93.84.0
One hour access (shock baseline)10.712.418.33.23.03.63.13.53.53.63.63.53.53.63.64.3
Number of responses in last shaping day1.41.41.90.70.21.41.31.21.41.31.41.31.11.31.30.8
Context. condit. distance diff. score1.82.33.31.51.11.61.81.61.41.51.61.41.41.61.51.3
Locomotion velocity, session 10.10.10.4-0.4-0.6-0.00.0-0.1-0.0-0.3-0.0-0.2-0.6-0.0-0.1-0.5
Locomotion distance, session 10.50.61.80.10.4-0.6-1.0-0.7-0.8-1.1-0.7-0.7-1.3-0.6-0.6-0.6
Locomotion velocity, session 22.93.45.4-1.0-0.5-1.8-2.3-1.9-2.0-2.1-1.8-2.2-2.2-1.8-1.9-1.5
Locomotion distance, session 20.60.92.0-0.20.1-0.9-1.3-0.9-1.0-1.2-0.8-1.0-1.4-0.9-0.8-1.0
Locomotion velocity, session 30.30.41.21.11.00.50.40.70.50.00.40.5-0.30.50.70.7
Locomotion distance, session 30.00.00.10.20.20.30.40.30.20.10.20.10.00.30.20.2
Stereotopy head waving bouts, day 30.60.81.71.30.90.80.41.00.90.30.80.9-0.00.81.11.0
Stereotopy head waving duration, day 30.80.91.31.10.91.00.61.11.00.61.01.00.51.01.21.1
Locomotion velocity, session 70.91.03.41.81.80.80.50.90.60.40.80.70.10.80.91.1
Locomotion distance, session 70.10.20.70.90.60.20.30.40.30.00.20.4-0.40.20.50.1
Stereotopy head waving bouts, day 70.30.31.10.81.10.40.50.30.20.30.40.50.40.40.30.9
Stereotopy head waving duration, day 70.81.01.9-0.30.4-1.0-1.1-1.3-1.4-1.1-1.0-1.0-0.9-1.0-1.2-0.5
Locomotion velocity, session 81.21.42.3-1.3-1.5-1.1-1.1-1.0-1.0-1.2-1.1-1.2-1.2-1.1-1.1-1.3
Locomotion distance, session 80.20.41.21.11.10.50.20.60.40.10.50.3-0.10.50.50.8
Degree of sensitization distance0.10.10.50.70.50.0-0.20.20.2-0.20.00.2-0.50.00.40.3
Degree of sensitization stereotypy0.30.40.8-0.10.4-0.7-0.5-0.8-0.9-0.6-0.7-0.6-0.4-0.7-0.8-0.1
Condit. Reinf. active minus inactive responses0.10.10.3-0.10.1-0.5-0.4-0.2-0.4-0.4-0.4-0.4-0.6-0.5-0.3-0.5
Condit. Reinf. active-inactive response ratio0.00.00.2-0.10.1-0.10.0-0.0-0.10.0-0.2-0.10.0-0.1-0.1-0.4
Condit. Reinf. active responses0.10.10.20.40.5-0.3-0.40.1-0.1-0.2-0.2-0.1-0.3-0.30.00.2
Condit. Reinf. inactive responses0.20.20.90.90.80.1-0.20.40.2-0.00.20.3-0.10.10.40.9
Incentive salience index mean0.30.40.90.10.4-0.6-0.9-0.4-0.6-0.7-0.6-0.6-0.9-0.6-0.5-0.4
Condit. Reinf. lever presses0.30.51.3-0.00.2-0.7-1.2-0.5-0.6-0.9-0.7-0.7-0.9-0.7-0.6-0.0
Time in familiar zone, hab. session 10.30.30.70.80.70.50.30.40.40.40.50.70.30.50.50.7
Time in novel zone, hab. session 10.20.20.5-0.3-0.70.40.50.40.50.40.40.20.30.40.4-0.3
Total zone transitions, hab. session 10.60.81.1-0.5-0.1-1.0-1.0-1.0-1.0-0.9-1.0-0.9-1.1-1.0-0.9-0.9
Total locomotion distance, hab. session 10.40.51.41.11.20.70.40.60.50.40.60.70.10.70.70.8
Locomotion velocity, hab. session 10.10.10.70.70.80.20.00.20.0-0.00.10.2-0.20.20.20.3
Time in familiar zone, hab. session 20.10.11.1-0.5-1.00.0-0.0-0.0-0.0-0.1-0.00.2-0.20.0-0.1-0.5
Time in novel zone, hab. session 20.10.10.60.30.8-0.2-0.2-0.1-0.3-0.1-0.2-0.3-0.1-0.2-0.1-0.0
Total zone transitions, hab. session 21.41.83.8-0.00.6-1.3-1.8-1.2-1.5-1.7-1.3-1.4-1.9-1.3-1.2-1.0
Total locomotion distance, hab. session 20.20.31.41.11.20.1-0.40.2-0.1-0.40.10.0-0.70.10.20.3
Locomotion velocity, hab. session 20.30.42.21.31.50.3-0.30.40.1-0.20.30.2-0.50.30.40.7
Novel to familiar place preference ratio0.90.91.6-0.50.2-1.2-1.2-1.1-1.2-0.9-1.1-1.0-0.8-1.2-1.2-0.4
Novelty place preference0.40.40.7-0.20.4-0.7-0.7-0.7-0.8-0.5-0.7-0.6-0.4-0.7-0.8-0.1
Time in novel zone, NPP test0.30.30.5-0.20.4-0.6-0.6-0.6-0.7-0.5-0.6-0.5-0.3-0.6-0.7-0.1
Total zone transitions, NPP test2.33.35.1-1.0-0.3-1.9-2.3-1.9-2.0-2.1-1.9-2.0-2.2-1.9-1.8-1.5
Total locomotion distance, NPP test0.10.10.50.50.6-0.2-0.5-0.1-0.3-0.5-0.2-0.3-0.7-0.2-0.0-0.1
Locomotion velocity, NPP test0.10.20.40.40.7-0.3-0.5-0.2-0.3-0.5-0.3-0.3-0.6-0.3-0.1-0.1
Pavlov. Cond. lever latency0.30.41.00.0-0.30.61.00.60.70.80.60.70.80.60.60.2
Pavlov. Cond. magazine entry latency0.20.30.80.40.9-0.4-0.6-0.6-0.8-0.5-0.4-0.4-0.6-0.4-0.6-0.2
Pavlov. Cond. change in total contacts0.10.11.10.41.0-0.2-0.3-0.2-0.4-0.1-0.2-0.2-0.1-0.2-0.30.3
Pavlov. Cond. index score0.10.20.4-0.10.3-0.4-0.6-0.5-0.6-0.4-0.4-0.4-0.4-0.4-0.6-0.2
Pavlov. Cond. latency score0.10.10.40.10.4-0.3-0.6-0.3-0.5-0.4-0.2-0.3-0.4-0.3-0.4-0.1
Pavlov. Cond. lever contacts0.00.00.20.20.3-0.1-0.3-0.1-0.2-0.3-0.1-0.1-0.4-0.1-0.2-0.0
Pavlov. Cond. magazine entry number0.20.30.50.40.00.60.50.70.70.40.60.50.20.60.70.4
Pavlov. Cond. intertrial magazine entries0.60.71.40.40.30.81.10.90.91.20.70.81.20.80.80.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.20.2-0.6-0.9-0.7-0.9-0.7-0.6-0.6-0.7-0.6-0.8-0.4
Pavlov. Cond. response bias0.10.10.2-0.10.1-0.3-0.2-0.4-0.4-0.2-0.3-0.3-0.2-0.3-0.4-0.2
Bone: apparent density0.30.61.10.50.9-0.7-0.7-0.8-1.0-1.0-0.7-0.5-0.9-0.7-0.70.0
Bone surface3.76.59.4-1.3-0.4-2.8-3.1-2.8-2.9-3.0-2.8-2.7-2.8-2.8-2.7-1.3
Bone volume1.11.93.0-0.20.6-1.5-1.7-1.6-1.7-1.7-1.6-1.4-1.5-1.5-1.5-0.2
Bone: connectivity density1.93.04.7-0.50.0-1.9-1.9-2.0-2.2-2.1-1.9-1.8-2.0-1.9-1.9-1.0
Bone: cortical apparent density0.30.31.1-0.7-0.5-0.7-0.3-0.4-0.5-0.3-0.6-0.7-0.3-0.7-0.5-1.1
Bone: cortical area0.60.81.3-0.8-0.4-1.0-1.1-1.0-1.0-1.0-1.0-1.0-0.8-1.0-1.1-0.4
Bone: cortical porosity0.10.10.20.20.4-0.3-0.3-0.3-0.3-0.4-0.3-0.4-0.3-0.3-0.2-0.1
Bone: cortical porosity0.60.60.9-0.4-0.1-0.9-0.9-0.8-0.9-0.9-0.9-1.0-0.8-0.9-0.8-0.7
Bone: cortical thickness2.84.66.1-2.4-2.3-2.1-1.9-2.1-2.0-2.0-2.2-2.2-1.7-2.1-2.2-2.5
Bone: cortical thickness0.70.92.3-1.3-1.5-0.7-0.1-0.7-0.7-0.7-0.8-0.7-0.8-0.7-0.8-1.5
Bone: cortical tissue density0.40.51.4-0.8-0.7-0.8-0.4-0.5-0.6-0.4-0.7-0.8-0.3-0.8-0.6-1.2
Bone: elastic displacement1.11.21.9-0.1-0.71.21.31.21.41.21.21.31.11.21.10.2
Bone: elastic work0.81.12.6-1.4-1.6-0.9-0.7-0.8-0.7-0.9-0.8-0.8-1.1-0.9-0.9-1.5
Bone: endosteal estimation1.02.25.72.22.41.30.81.21.00.71.31.40.51.31.32.3
Bone: endosteal perimeter1.42.98.02.42.61.51.01.41.21.01.51.60.91.51.52.8
Bone: final force2.94.86.3-1.5-1.0-2.4-2.5-2.2-2.3-2.5-2.4-2.4-2.4-2.4-2.2-1.5
Bone: final moment2.54.25.6-1.4-1.0-2.2-2.4-2.1-2.1-2.4-2.3-2.2-2.2-2.2-2.1-1.4
Bone: marrow area1.12.45.92.32.41.40.81.31.00.71.41.40.51.41.32.4
Bone: maximum diameter0.20.30.8-0.30.1-0.5-0.9-0.6-0.5-0.6-0.5-0.5-0.4-0.5-0.60.5
Bone: maximum force3.05.27.8-1.0-0.2-2.6-2.6-2.3-2.6-2.8-2.6-2.5-2.7-2.6-2.3-1.1
Bone: maximum moment2.54.46.8-0.8-0.1-2.3-2.4-2.1-2.4-2.6-2.4-2.3-2.5-2.3-2.2-1.0
Bone: minimum diameter1.12.16.82.32.61.20.91.10.70.71.21.30.61.21.22.0
Bone: periosteal estimation0.10.31.60.81.20.2-0.20.1-0.1-0.30.10.2-0.20.20.11.2
Bone: periosteal perimeter0.10.20.40.20.6-0.3-0.6-0.3-0.3-0.5-0.3-0.2-0.4-0.3-0.30.7
Bone: post-yield work1.21.68.42.02.9-0.7-1.1-0.3-1.0-1.1-0.7-0.7-1.0-0.7-0.31.4
Bone: stiffness2.43.85.3-0.70.1-2.2-2.1-2.1-2.2-2.3-2.2-2.2-2.2-2.2-2.0-0.9
Bone: tissue strength0.00.00.20.10.2-0.2-0.30.00.0-0.1-0.2-0.40.1-0.20.00.2
Bone: trabecular number0.40.61.10.30.8-0.8-0.7-0.9-1.0-0.9-0.8-0.5-0.7-0.8-0.80.1
Bone: trabecular spacing0.20.20.40.1-0.20.50.50.60.60.50.60.30.30.50.6-0.2
Bone: trabecular thickness0.80.91.91.31.40.80.80.80.80.80.81.00.90.80.91.1
Bone: trabecular tissue density3.54.96.21.61.22.32.32.32.32.42.32.32.52.32.32.1
Breakpoint value in progressive ratio session3.03.44.6-1.5-1.1-2.1-1.8-1.9-2.0-1.9-2.1-1.9-1.5-2.1-2.1-1.5
Distance traveled before self-admin0.50.61.4-0.5-0.2-0.8-1.2-0.8-0.8-0.8-0.8-0.9-0.6-0.8-0.8-0.3
Distance traveled after self-admin0.20.20.4-0.4-0.1-0.6-0.5-0.4-0.4-0.3-0.6-0.50.1-0.6-0.4-0.2
Delta time in closed arm before/after self-admin0.20.20.5-0.3-0.7-0.2-0.5-0.10.1-0.3-0.1-0.0-0.7-0.10.0-0.7
Delta time in open arm before/after self-admin0.10.10.2-0.30.0-0.20.3-0.2-0.30.1-0.3-0.20.5-0.2-0.40.1
Diff in mean of infusions in LGA sessions0.50.50.9-0.9-0.8-0.8-0.7-0.6-0.8-0.5-0.7-0.6-0.4-0.7-0.9-0.7
Extinction: sum of active levers before priming4.54.56.4-1.3-0.6-2.4-2.2-2.3-2.5-2.3-2.4-2.2-2.1-2.4-2.4-1.8
Active lever presses in extinction session 62.82.74.4-1.9-1.6-1.6-2.1-1.7-1.5-1.6-1.5-1.7-1.1-1.6-1.8-1.1
Delta distance traveled before/after self-admin0.10.10.2-0.1-0.20.00.40.20.30.20.10.20.30.00.3-0.1
Delta ambulatory time before/after self-admin0.00.00.2-0.3-0.4-0.10.20.10.20.1-0.00.10.1-0.10.2-0.4
Time in closed arm before self-admin0.00.00.10.10.4-0.1-0.1-0.2-0.2-0.2-0.2-0.20.0-0.1-0.20.4
Time in closed arm after self-admin0.10.10.20.40.20.0-0.20.20.40.10.00.3-0.10.00.40.1
Time in open arm before self-admin0.40.40.80.4-0.00.70.70.80.70.70.90.80.10.80.8-0.4
Time in open arm after self-admin0.20.20.9-0.3-0.40.50.90.40.30.60.50.40.70.50.2-0.2
Sum of active levers in priming session hrs 5-61.61.53.1-1.8-1.5-1.3-1.5-1.2-1.0-0.9-1.3-1.2-0.5-1.4-1.2-0.5
Time to tail flick, vehicle, before self-admin0.60.61.7-0.10.1-0.5-1.1-0.8-0.9-0.9-0.6-0.7-1.3-0.6-0.8-0.2
Time to tail flick, vehicle, after self-admin1.61.73.6-0.5-0.3-1.0-1.2-1.3-1.7-1.7-1.1-1.3-1.9-1.1-1.6-1.1
Time to tail flick, test, before self-admin0.90.82.41.61.31.00.60.80.60.50.90.80.20.90.90.9
Time to tail flick, test, after self-admin0.00.00.1-0.4-0.3-0.1-0.2-0.1-0.1-0.1-0.1-0.2-0.3-0.1-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.50.40.8-0.3-0.2-0.6-0.5-0.6-0.9-0.9-0.7-0.7-0.8-0.6-0.8-0.8
Delta time to tail flick, test, before/after SA1.81.64.6-2.2-2.0-1.2-0.9-1.2-0.8-0.7-1.1-1.2-0.7-1.1-1.2-1.4
Ambulatory time before self-admin0.30.30.5-0.3-0.0-0.7-0.7-0.6-0.6-0.6-0.7-0.7-0.2-0.7-0.70.1
Ambulatory time after self-admin0.20.21.00.61.00.10.20.30.30.40.10.30.80.00.30.7
Total heroin consumption6.07.18.5-2.2-1.7-2.9-2.8-2.8-2.9-2.7-2.8-2.8-2.7-2.8-2.9-2.5
Area under the delay curve0.10.10.70.70.80.30.4-0.0-0.30.00.30.2-0.30.4-0.1-0.1
Delay disc. indifference point, 0s delay0.40.41.01.01.00.80.80.40.00.31.00.5-0.10.90.20.2
Delay disc. indifference point, 16s delay1.21.22.81.41.71.01.21.10.71.10.91.11.00.90.91.0
Delay disc. indifference point, 2s delay0.10.10.30.50.60.30.30.1-0.00.10.40.3-0.10.4-0.00.4
Delay disc. indifference point, 24s delay0.10.10.2-0.1-0.30.40.00.20.10.20.30.3-0.20.40.0-0.4
Delay disc. indifference point, 4s delay0.10.10.30.60.40.50.50.1-0.10.10.50.4-0.20.6-0.0-0.2
Delay disc. indifference point, 8s delay0.10.10.10.30.20.20.4-0.0-0.2-0.00.30.1-0.30.3-0.1-0.4
Delay discount exponential model param0.10.10.4-0.5-0.7-0.3-0.30.10.30.0-0.3-0.10.4-0.30.20.2
Delay discount hyperbolic model param0.10.10.3-0.4-0.6-0.2-0.30.10.40.1-0.2-0.10.5-0.30.20.2
Fecal boli incidents, locomotor time 10.10.10.40.00.6-0.0-0.0-0.3-0.4-0.1-0.2-0.20.1-0.1-0.50.6
Change in fecal boli incidents, locomotor task0.10.10.30.2-0.2-0.1-0.50.10.2-0.3-0.00.1-0.5-0.10.4-0.3
Time >=10cm from walls, locomotor time 11.31.34.51.82.10.80.30.80.60.50.70.80.50.70.82.0
Bouts of movement, locomotor time 11.41.52.6-1.4-0.9-1.4-1.2-1.3-1.1-0.8-1.4-1.4-0.3-1.3-1.2-1.6
Total resting periods, locomotor time 10.91.01.4-1.1-0.6-1.2-1.1-1.1-1.0-0.6-1.2-1.1-0.2-1.1-1.0-1.2
Rest time, locomotor task time 11.31.42.30.60.41.30.71.31.51.31.31.21.41.31.41.2
Distance moved, locomotor task time 10.20.20.50.40.5-0.3-0.3-0.2-0.6-0.4-0.3-0.2-0.7-0.3-0.4-0.1
Vertical activity count, locomotor time 11.41.52.31.10.91.21.51.31.21.31.21.41.01.21.31.1
Time >=10cm from walls, locomotor time 20.00.00.10.10.3-0.1-0.3-0.1-0.2-0.1-0.1-0.30.3-0.2-0.10.2
Bouts of movement, locomotor time 20.50.51.0-0.6-0.4-0.9-0.4-0.8-0.8-0.4-0.8-0.7-0.3-0.8-0.8-1.0
Total resting periods, locomotor time 20.20.20.4-0.3-0.0-0.6-0.1-0.6-0.6-0.2-0.6-0.5-0.1-0.6-0.5-0.6
Rest time, locomotor task time 22.73.13.81.61.41.91.81.81.81.61.91.61.61.92.01.8
Distance moved, locomotor task time 21.21.41.8-1.2-1.1-1.3-1.3-1.1-1.1-1.1-1.2-1.2-1.1-1.3-1.2-1.3
Vertical activity count, locomotor time 20.20.21.9-0.9-1.4-0.10.10.30.40.2-0.00.20.0-0.10.1-0.5
Weight adjusted by age2.32.54.3-1.5-1.1-1.7-2.1-1.5-1.6-1.6-1.6-1.5-1.8-1.7-1.6-1.3
Seeking ratio, delayed vs. immediate footshock0.10.10.50.70.70.00.40.40.20.3-0.10.20.40.00.40.0
Locomotion in novel chamber5.36.69.32.21.82.62.32.72.72.62.62.52.62.62.83.0
Locomotion in novel chamber post-restriction3.33.94.71.71.42.02.22.02.02.12.12.02.12.01.92.1
Progressive ratio2.22.64.9-0.10.6-1.5-2.2-1.8-2.0-2.0-1.6-1.7-1.7-1.5-1.7-0.8
Food seeking constrained by brief footshock0.20.30.6-0.6-0.8-0.5-0.4-0.4-0.4-0.4-0.5-0.3-0.3-0.5-0.4-0.8
Seeking ratio, punishment vs. effort1.72.14.50.2-0.71.42.11.71.71.81.51.61.51.41.60.5
Run reversals in cocaine runway, females0.60.61.80.50.6-0.5-0.8-0.6-0.9-1.0-0.6-0.6-1.4-0.5-0.6-0.7
Run reversals in cocaine runway, males0.40.40.9-0.5-1.00.50.90.60.70.60.50.50.60.50.40.2
Latency to leave start box in cocaine runway0.20.21.30.91.20.20.20.2-0.10.00.00.20.20.20.20.6
Latency to leave start box in cocaine runway, F0.10.10.70.50.80.20.4-0.1-0.30.0-0.1-0.00.00.2-0.20.1
Latency to leave start box in cocaine runway, M0.10.10.30.40.3-0.0-0.40.30.1-0.1-0.00.20.1-0.00.30.5
Cd content in liver1.31.43.10.60.41.21.81.01.21.41.21.11.61.20.91.3
Co content in liver1.31.53.10.0-0.61.31.81.21.41.61.31.11.51.31.2-0.1
Cu content in liver0.20.20.5-0.10.2-0.5-0.5-0.6-0.7-0.4-0.5-0.5-0.2-0.5-0.6-0.6
Fe content in liver0.20.20.4-0.4-0.4-0.3-0.6-0.5-0.5-0.5-0.3-0.3-0.5-0.3-0.6-0.0
K content in liver1.61.63.0-0.20.2-1.3-1.6-1.2-1.5-1.6-1.3-1.3-1.7-1.3-1.3-0.7
Mg content in liver0.30.31.71.01.3-0.2-0.5-0.1-0.5-0.5-0.3-0.2-0.7-0.2-0.10.1
Mn content in liver2.42.84.0-1.3-0.8-1.8-2.0-1.7-1.8-1.7-1.8-1.8-1.5-1.8-1.9-1.1
Na content in liver1.21.21.5-1.2-0.9-1.2-1.1-1.2-1.0-1.2-1.2-1.2-1.2-1.2-1.1-0.7
Rb content in liver1.82.33.51.81.71.51.91.61.31.41.51.61.21.51.51.3
Se content in liver0.10.10.70.40.70.1-0.4-0.0-0.10.10.10.10.50.1-0.10.9
Sr content in liver3.73.44.9-2.2-1.9-1.9-1.6-2.0-1.7-1.6-1.9-1.9-1.3-1.9-2.0-1.9
Zn content in liver1.11.21.9-0.6-0.2-1.2-1.4-1.3-1.3-1.1-1.3-1.2-0.9-1.2-1.2-1.1