Hub : Genes

Rab5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	ENSRNOG00000006130	0.21	0.13	2.7e-03	0.03	0.04	0.04	0.03	8.2e-02	4.7e-02	4.9e-02	7.3e-02
2	NAcc	mRNA stability	ENSRNOG00000006130	0.03	0.03	7.1e-03	0.01	0.03	0.02	0.01	3.9e-02	5.3e-03	1.3e-02	2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	8.6	27.8	28.0	-5.3	5.3
BMI without tail	1.7	3.5	3.7	-1.8	1.9
Body weight	1.6	6.7	6.8	-2.6	2.6
Epididymis fat weight	0.1	0.1	0.2	0.4	-0.3
Glucose	2.3	3.5	3.5	-1.9	1.9
Heart weight	0.0	0.0	0.0	0.0	0.1
Left kidney weight	0.1	0.2	0.3	-0.6	0.2
Right kidney weight	0.3	0.8	1.0	0.8	-1.0
Tail length	5.0	15.1	16.0	4.0	-3.8
Length with tail	1.7	6.1	6.2	2.5	-2.5
Length without tail	0.1	0.2	0.3	-0.6	0.3
Liver weight, left	1.5	2.5	2.7	-1.5	1.6
Liver weight, right	1.0	1.6	1.7	-1.3	1.2
Parametrial fat weight	0.0	0.1	0.1	0.3	-0.3
Retroperitoneal fat weight	2.7	9.0	9.4	-2.9	3.1
Intraocular pressure	0.3	0.4	0.6	0.8	-0.5
Extensor digitorum longus weight	6.2	24.7	26.1	-4.8	5.1
Soleus weight	7.5	22.0	22.0	-4.7	4.7
Tibialis anterior weight	1.5	5.3	5.3	-2.3	2.3
Tibia length	1.0	2.9	3.0	1.7	-1.7
Number of licking bursts	3.8	4.5	4.9	-2.0	2.2
Food consumed during 24 hour testing period	0.5	0.6	0.6	-0.8	0.7
Times rat made contact with spout	1.2	1.4	1.5	-1.1	1.2
Mean time between licks in bursts	1.1	1.6	1.7	1.3	-1.2
Mean num. licks in bursts	0.9	1.0	1.1	1.0	-1.0
Std. dev. time between licks in bursts	0.6	0.8	1.0	0.7	-1.0
Water consumed over 24 hours	0.8	0.9	1.2	-1.1	0.8
Indifference point 0 sec	3.8	6.2	6.5	-2.5	2.4
Indifference point AUC	0.6	0.7	0.7	0.8	-0.8
Indifference point function ln k	0.1	0.1	0.2	-0.4	0.4
Indifference point function log k	0.1	0.1	0.2	-0.4	0.4
Delay discounting total patch changes 0 sec	3.5	5.7	5.9	-2.4	2.3
Delay discounting total patch changes 12 sec	1.9	2.5	2.7	-1.5	1.7
Delay discounting total patch changes 18 sec	0.0	0.0	0.0	-0.2	0.2
Delay discounting total patch changes 24 sec	0.7	0.9	0.9	-1.0	0.9
Delay discounting total patch changes 6 sec	2.0	3.0	3.1	-1.7	1.7
Delay discounting time to switch 0 sec	0.3	0.4	0.5	-0.7	0.5
Delay discounting water rate 0 sec	0.5	0.7	0.9	-0.7	1.0
Delay discounting water rate 12 sec	0.8	1.1	1.4	-0.9	1.2
Delay discounting water rate 18 sec	0.0	0.1	0.1	0.3	0.3
Delay discounting water rate 24 sec	1.4	1.9	2.7	-1.0	1.6
Delay discounting water rate 6 sec	0.5	0.7	1.0	1.0	-0.6
Locomotor activity	3.3	5.3	5.8	2.2	-2.4
Locomotor testing distance	1.3	2.2	2.4	1.4	-1.6
Locomotor testing rearing	0.0	0.0	0.0	0.0	0.1
Light reinforcement 1	4.1	7.5	7.6	2.7	-2.8
Light reinforcement 2	1.2	1.5	1.6	1.2	-1.2
Reaction time number correct	1.1	1.6	1.8	-1.1	1.4
Reaction time mean minus median	1.5	2.0	2.0	1.4	-1.4
Reaction time mean minus median AUC	1.5	1.9	2.4	1.2	-1.5
Reaction time num false alarms	0.7	0.9	1.0	-0.9	1.0
Reaction time num false alarms AUC	0.8	1.1	1.2	-1.0	1.1
Reaction time trials correct on left	1.1	1.6	1.8	-1.1	1.4
Reaction time trials on left	1.1	1.5	1.7	-1.1	1.3
Reaction time mean	1.2	1.7	2.0	1.2	-1.4
Reaction time mean AUC	0.5	0.7	0.9	0.7	-0.9
Median of all reaction times	0.6	0.8	1.0	0.8	-1.0
Reaction time omissions	0.0	0.0	0.0	0.0	-0.1
Reaction time false alarm rate	0.1	0.2	0.2	-0.4	0.4
Reaction time premature initiation rate	1.4	1.9	2.2	1.5	-1.2
Reaction time premature initiations	0.4	0.5	0.8	0.9	-0.5
Std. dev. reaction times	0.9	1.3	1.5	1.0	-1.2
Reaction time trials completed	1.1	1.5	1.7	-1.1	1.3
Reaction time trials AUC	1.2	1.7	2.0	-1.2	1.4
Social response proportion	0.7	0.8	0.9	0.8	-1.0
Social responses	9.5	12.3	13.0	3.4	-3.6
Social time	1.5	1.9	2.0	-1.4	1.4
Conditioned locomotion	1.2	1.4	1.7	-1.0	1.3
Cocaine response after cond. corrected	2.4	2.6	3.1	-1.5	1.8
Cocaine response after cond. not corrected	2.4	2.6	3.2	-1.5	1.8
Cocaine response before conditioning	0.6	0.7	0.8	0.8	-0.9
Saline control response	0.5	0.6	0.7	-0.7	0.8
Condit. Reinf. active minus inactive responses	2.4	3.0	3.4	1.8	-1.6
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	0.9	-0.6
Condit. Reinf. active responses	1.8	2.6	2.7	1.6	-1.6
Condit. Reinf. inactive responses	0.4	0.5	0.7	0.7	-0.8
Condit. Reinf. lever presses	3.2	4.3	4.7	2.2	-2.0
Condit. Reinf. lever reinforcers received	1.4	1.9	2.1	1.4	-1.3
Pavlov. Cond. lever latency	1.7	2.4	2.4	-1.5	1.5
Pavlov. Cond. magazine entry latency	2.8	3.2	3.3	1.8	-1.8
Pavlov. Cond. change in total contacts	0.9	1.3	1.3	1.2	-1.1
Pavlov. Cond. index score	2.5	3.2	3.3	1.8	-1.8
Pavlov. Cond. latency score	2.5	3.2	3.2	1.8	-1.8
Pavlov. Cond. lever contacts	1.5	2.1	2.2	1.5	-1.4
Pavlov. Cond. magazine entry number	2.6	3.2	3.2	-1.8	1.8
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.5	-1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.4	3.4	1.8	-1.8
Pavlov. Cond. response bias	2.5	3.5	3.6	1.9	-1.8
Conditioned reinforcement - actives	0.1	0.1	0.2	0.3	-0.4
Conditioned reinforcement - inactives	0.7	0.8	1.0	-0.8	1.0
Conditioned locomotion	3.9	4.7	4.8	2.1	-2.2
Intermittent access intake day 1-15 change	0.6	0.6	0.7	0.8	-0.7
Intermittent access intake escalation	0.3	0.3	0.5	0.7	-0.3
Intermittent access intake escalation 2	0.9	0.9	1.2	1.1	-0.8
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	0.5	-0.2
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.4	1.2	-0.9
Intermitt. access escalation Index	0.2	0.1	0.2	0.2	-0.5
Intermittent access day 1 total infusions	0.3	0.4	0.4	-0.7	0.6
Intermittent access day 15 total infusions	0.0	0.1	0.1	-0.2	0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.3	0.2
Intermittent access total infusions	0.3	0.3	0.3	-0.6	0.6
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.0	0.0
Intermittent access day 15 total locomotion	0.8	0.8	0.9	0.9	-0.8
Intermittent access total locomotion	0.3	0.4	0.4	0.6	-0.6
Intermittent access standard deviation	0.3	0.3	0.4	0.6	-0.5
Cocaine induced anxiety	1.5	1.7	2.1	1.2	-1.4
Post-drug Anxiety	0.3	0.3	0.5	0.3	-0.7
Baseline Anxiety	0.0	0.0	0.0	-0.0	0.1
Lifetime Intake	0.8	0.9	1.0	-1.0	0.9
Incentive Sensitization - Responses	0.2	0.2	0.2	0.4	-0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	0.5	-0.6
Progressive ratio test 1 active lever presses	1.3	1.4	1.4	-1.2	1.2
Progressive ratio test 1 breakpoint	1.4	1.5	1.5	-1.2	1.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Progressive ratio test 2 active lever presses	0.4	0.4	0.4	-0.6	0.6
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.3	0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.4	0.3
Total sessions with >9 infusions	0.1	0.1	0.1	-0.4	0.0
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.1	-0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.3	-0.1
Short access day 1 total infusions	0.5	0.5	0.7	-0.8	0.5
Short access day 10 total infusions	0.5	0.6	0.6	-0.8	0.7
Short access total infusions	1.3	1.4	1.7	-1.3	1.0
Short access day 1 locomotion	0.2	0.2	0.2	0.3	-0.5
Short access day 10 total locomotion	2.5	2.7	3.1	1.8	-1.6
Short access total locomotion	0.4	0.4	0.4	0.6	-0.7
Compulsive drug intake	0.3	0.3	0.3	-0.6	0.5
One hour access (0.3 mA shock)	0.4	0.4	0.4	-0.7	0.7
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.2
Number of responses in last shaping day	1.6	1.6	1.6	1.3	-1.3
Context. condit. distance diff. score	0.2	0.3	0.3	-0.5	0.6
Locomotion velocity, session 1	0.2	0.2	0.3	-0.5	0.2
Locomotion distance, session 1	0.1	0.2	0.3	0.2	-0.6
Locomotion velocity, session 2	1.3	1.5	2.0	1.0	-1.4
Locomotion distance, session 2	2.4	3.4	4.2	1.6	-2.0
Locomotion velocity, session 3	5.3	6.2	6.3	2.5	-2.5
Locomotion distance, session 3	0.1	0.1	0.1	0.3	-0.2
Stereotopy head waving bouts, day 3	6.7	8.0	8.3	2.8	-2.9
Stereotopy head waving duration, day 3	4.8	5.8	6.0	2.4	-2.4
Locomotion velocity, session 7	0.1	0.1	0.1	0.2	-0.3
Locomotion distance, session 7	0.1	0.1	0.1	-0.2	0.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	0.8	-1.0
Stereotopy head waving duration, day 7	0.5	0.6	0.9	0.6	-0.9
Locomotion velocity, session 8	1.0	1.2	1.7	0.9	-1.3
Locomotion distance, session 8	0.3	0.4	0.5	0.6	-0.7
Degree of sensitization distance	0.6	0.6	0.6	-0.8	0.8
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.5	0.3
Condit. Reinf. active minus inactive responses	2.4	2.7	2.7	1.6	-1.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	0.7	-0.6
Condit. Reinf. active responses	3.3	4.0	4.4	1.9	-2.1
Condit. Reinf. inactive responses	1.5	1.8	2.1	1.2	-1.5
Incentive salience index mean	1.4	1.7	1.9	1.2	-1.4
Condit. Reinf. lever presses	0.1	0.2	0.4	0.2	-0.6
Time in familiar zone, hab. session 1	5.5	5.2	5.5	2.3	-2.2
Time in novel zone, hab. session 1	3.7	3.6	4.2	-2.1	1.7
Total zone transitions, hab. session 1	0.4	0.5	0.8	0.5	-0.9
Total locomotion distance, hab. session 1	1.6	2.3	3.1	1.3	-1.8
Locomotion velocity, hab. session 1	1.9	2.7	3.3	1.4	-1.8
Time in familiar zone, hab. session 2	5.6	5.8	6.4	2.5	-2.3
Time in novel zone, hab. session 2	6.0	6.0	6.8	-2.6	2.3
Total zone transitions, hab. session 2	0.5	0.6	0.9	-1.0	0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.4	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.6	0.4	-0.8
Novel to familiar place preference ratio	3.1	3.2	3.8	-2.0	1.6
Novelty place preference	1.9	2.0	2.5	-1.6	1.3
Time in novel zone, NPP test	2.6	2.7	3.2	-1.8	1.5
Total zone transitions, NPP test	0.4	0.6	0.7	-0.9	0.6
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.4	0.1
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.0	0.3
Pavlov. Cond. magazine entry latency	1.8	2.3	2.4	1.5	-1.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	0.3
Pavlov. Cond. index score	0.4	0.6	0.7	0.7	-0.8
Pavlov. Cond. latency score	0.5	0.6	0.8	0.7	-0.9
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. magazine entry number	0.6	0.7	0.7	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	0.8	-1.0
Pavlov. Cond. response bias	0.7	0.9	0.9	0.9	-1.0
Bone: apparent density	0.1	0.1	0.1	-0.3	-0.3
Bone surface	0.3	0.5	1.0	0.2	-1.0
Bone volume	0.2	0.3	0.5	-0.1	-0.7
Bone: connectivity density	0.0	0.1	0.1	-0.1	-0.3
Bone: cortical apparent density	1.5	1.9	1.9	-1.4	1.4
Bone: cortical area	0.8	1.1	1.5	-1.2	0.9
Bone: cortical porosity	0.1	0.1	0.1	0.2	-0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.3	0.0
Bone: cortical thickness	1.4	2.3	2.6	-1.6	1.4
Bone: cortical thickness	1.0	1.1	1.2	-1.0	1.1
Bone: cortical tissue density	1.0	1.4	1.4	-1.2	1.2
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.1
Bone: elastic work	0.7	0.9	1.0	-1.0	0.8
Bone: endosteal estimation	0.5	1.1	1.3	-1.2	1.0
Bone: endosteal perimeter	0.3	0.5	0.7	0.6	-0.9
Bone: final force	2.8	4.6	5.3	-2.3	2.0
Bone: final moment	2.7	4.4	5.1	-2.3	1.9
Bone: marrow area	0.5	1.0	1.2	-1.1	0.9
Bone: maximum diameter	0.3	0.6	0.9	0.6	-1.0
Bone: maximum force	3.0	5.2	5.9	-2.4	2.1
Bone: maximum moment	2.9	5.1	5.7	-2.4	2.1
Bone: minimum diameter	0.1	0.2	0.4	-0.6	0.3
Bone: periosteal estimation	0.8	1.7	2.2	-1.5	1.1
Bone: periosteal perimeter	0.0	0.0	0.1	-0.1	-0.2
Bone: post-yield work	0.4	0.5	0.5	-0.7	0.7
Bone: stiffness	4.9	7.8	8.4	-2.9	2.7
Bone: tissue strength	4.6	4.5	4.8	-2.2	2.1
Bone: trabecular number	0.6	1.0	1.4	0.8	-1.2
Bone: trabecular spacing	0.2	0.3	0.5	-0.1	0.7
Bone: trabecular thickness	0.1	0.2	0.3	-0.5	-0.2
Bone: trabecular tissue density	6.3	8.8	9.4	-2.9	3.1
Breakpoint value in progressive ratio session	2.4	2.6	2.9	1.7	-1.6
Distance traveled before self-admin	1.0	1.1	1.1	1.0	-1.0
Distance traveled after self-admin	0.2	0.3	0.3	0.5	-0.6
Delta time in closed arm before/after self-admin	0.6	0.6	1.0	-0.5	1.0
Delta time in open arm before/after self-admin	2.0	1.9	2.1	-1.4	1.3
Diff in mean of infusions in LGA sessions	2.6	2.9	3.0	1.7	-1.7
Extinction: sum of active levers before priming	2.9	3.0	3.5	1.9	-1.6
Active lever presses in extinction session 6	1.2	1.1	1.2	1.0	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.2	0.1
Time in closed arm before self-admin	0.2	0.2	0.3	-0.6	0.3
Time in closed arm after self-admin	0.2	0.2	0.2	-0.4	0.4
Time in open arm before self-admin	0.6	0.7	0.8	0.9	-0.7
Time in open arm after self-admin	1.3	1.4	1.5	-1.1	1.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.6	-0.6
Time to tail flick, vehicle, before self-admin	2.0	2.1	2.6	1.3	-1.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	0.6	-0.4
Time to tail flick, test, before self-admin	1.1	1.1	1.4	0.9	-1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	-0.4
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	1.8	-1.0	1.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	-0.1
Ambulatory time before self-admin	0.3	0.3	0.3	0.5	-0.5
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	-0.2
Total heroin consumption	2.5	3.0	3.1	1.7	-1.8
Area under the delay curve	0.1	0.1	0.1	-0.3	0.2
Delay disc. indifference point, 0s delay	1.7	1.8	2.4	-1.5	1.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 2s delay	0.3	0.4	0.5	-0.7	0.5
Delay disc. indifference point, 24s delay	0.5	0.5	0.6	-0.7	0.7
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.4	-0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	-0.4	0.5
Delay discount exponential model param	0.0	0.1	0.1	0.3	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.2	0.5	-0.3
Fecal boli incidents, locomotor time 1	0.8	0.9	1.1	-0.8	1.1
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.5	-0.8
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.8	-0.9	0.7
Bouts of movement, locomotor time 1	0.6	0.6	0.7	0.8	-0.8
Total resting periods, locomotor time 1	1.3	1.4	1.4	1.2	-1.2
Rest time, locomotor task time 1	0.4	0.5	0.5	0.6	-0.7
Distance moved, locomotor task time 1	0.6	0.6	0.8	-0.9	0.7
Vertical activity count, locomotor time 1	1.1	1.1	1.2	-1.0	1.1
Time >=10cm from walls, locomotor time 2	1.2	1.2	1.4	-1.1	1.2
Bouts of movement, locomotor time 2	0.3	0.3	0.4	0.4	-0.6
Total resting periods, locomotor time 2	0.2	0.3	0.4	0.3	-0.6
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.2
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.1	0.3
Vertical activity count, locomotor time 2	1.4	1.6	1.9	-1.1	1.4
Weight adjusted by age	0.0	0.0	0.0	0.1	0.1
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.2	1.3	-1.5
Locomotion in novel chamber	0.2	0.2	0.2	-0.4	0.4
Locomotion in novel chamber post-restriction	3.9	4.6	4.7	2.2	-2.1
Progressive ratio	1.2	1.4	1.5	-1.1	1.2
Food seeking constrained by brief footshock	1.5	1.9	1.9	1.4	-1.4
Seeking ratio, punishment vs. effort	2.3	2.8	2.8	1.7	-1.7
Run reversals in cocaine runway, females	2.0	2.0	2.2	1.3	-1.5
Run reversals in cocaine runway, males	3.0	2.9	3.1	1.6	-1.8
Latency to leave start box in cocaine runway	0.1	0.2	0.3	-0.5	0.2
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	-0.7	0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	0.2
Cd content in liver	0.4	0.4	0.4	-0.6	0.6
Co content in liver	1.3	1.6	1.8	1.3	-1.2
Cu content in liver	0.9	1.1	1.4	-1.2	0.9
Fe content in liver	0.5	0.6	0.7	-0.7	0.8
K content in liver	0.6	0.6	0.8	0.7	-0.9
Mg content in liver	0.3	0.3	0.5	0.4	-0.7
Mn content in liver	0.5	0.5	0.9	0.4	-1.0
Na content in liver	0.1	0.1	0.2	-0.4	0.3
Rb content in liver	0.3	0.4	0.6	-0.8	0.5
Se content in liver	0.0	0.0	0.1	0.2	-0.2
Sr content in liver	0.3	0.2	0.4	0.6	-0.3
Zn content in liver	1.8	2.0	2.6	1.6	-1.2