Hub : Genes

Socs7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000059008	0.1	0.07	1.7e-09	0.09	0.08	0.08	0.09	3.1e-10	2.5e-09	2.9e-09	1.1e-09
2	Brain	gene expression	ENSRNOG00000059008	0.07	0.05	9.9e-07	0.07	0.06	0.06	0.07	4.5e-07	2.9e-06	3.0e-06	3.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.2	3.9	4.0	1.9	-2.0
BMI without tail	0.1	0.2	0.3	0.4	-0.5
Body weight	4.9	20.6	21.5	4.4	-4.6
Epididymis fat weight	0.2	0.4	0.6	0.8	-0.5
Glucose	0.5	0.8	0.9	-0.9	0.9
Heart weight	2.7	3.8	4.3	2.1	-1.8
Left kidney weight	2.6	7.5	7.9	2.8	-2.7
Right kidney weight	0.7	2.0	2.3	1.5	-1.3
Tail length	1.1	3.4	3.5	1.8	-1.9
Length with tail	4.7	17.2	17.4	4.1	-4.2
Length without tail	4.2	9.1	9.1	3.0	-3.0
Liver weight, left	0.1	0.2	0.3	0.5	-0.3
Liver weight, right	0.0	0.0	0.0	0.1	0.1
Parametrial fat weight	1.0	2.1	2.2	-1.5	1.4
Retroperitoneal fat weight	0.0	0.1	0.1	0.3	-0.2
Intraocular pressure	1.1	1.5	1.6	1.3	-1.2
Extensor digitorum longus weight	7.9	31.9	32.6	5.6	-5.7
Soleus weight	0.5	1.4	1.4	-1.2	1.1
Tibialis anterior weight	1.5	5.0	5.1	2.3	-2.2
Tibia length	1.0	2.7	3.1	1.8	-1.5
Number of licking bursts	0.4	0.4	0.5	-0.6	0.7
Food consumed during 24 hour testing period	1.2	1.5	1.6	1.2	-1.3
Times rat made contact with spout	0.5	0.6	0.6	-0.8	0.8
Mean time between licks in bursts	1.1	1.5	1.7	1.2	-1.3
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	0.1
Std. dev. time between licks in bursts	0.2	0.3	0.4	0.4	-0.6
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.0
Indifference point 0 sec	1.6	2.6	3.1	-1.8	1.4
Indifference point AUC	0.4	0.5	0.6	0.8	-0.6
Indifference point function ln k	0.1	0.1	0.1	-0.3	0.2
Indifference point function log k	0.1	0.1	0.1	-0.3	0.2
Delay discounting total patch changes 0 sec	1.0	1.7	2.0	-1.4	1.1
Delay discounting total patch changes 12 sec	4.3	5.8	6.3	-2.5	2.3
Delay discounting total patch changes 18 sec	0.2	0.2	0.3	-0.6	0.4
Delay discounting total patch changes 24 sec	1.1	1.4	1.5	-1.2	1.2
Delay discounting total patch changes 6 sec	1.0	1.5	1.7	-1.3	1.1
Delay discounting time to switch 0 sec	0.1	0.2	0.2	-0.4	0.4
Delay discounting water rate 0 sec	0.1	0.2	0.2	0.5	-0.3
Delay discounting water rate 12 sec	0.3	0.5	0.5	0.7	-0.7
Delay discounting water rate 18 sec	0.6	0.8	1.0	-0.8	1.0
Delay discounting water rate 24 sec	0.5	0.6	0.7	-0.8	0.8
Delay discounting water rate 6 sec	0.5	0.8	1.1	-0.7	1.1
Locomotor activity	0.6	0.9	1.0	-1.0	0.9
Locomotor testing distance	3.5	5.8	5.8	-2.4	2.4
Locomotor testing rearing	4.6	7.3	8.2	-2.5	2.9
Light reinforcement 1	2.5	4.5	4.8	-2.2	2.1
Light reinforcement 2	0.7	0.9	1.0	-1.0	0.9
Reaction time number correct	0.4	0.6	1.0	0.6	-1.0
Reaction time mean minus median	0.0	0.0	0.0	-0.2	-0.0
Reaction time mean minus median AUC	0.7	0.9	1.1	-1.0	0.8
Reaction time num false alarms	0.9	1.2	1.2	-1.1	1.1
Reaction time num false alarms AUC	0.7	1.0	1.0	-1.0	0.9
Reaction time trials correct on left	0.4	0.6	1.0	0.6	-1.0
Reaction time trials on left	0.4	0.6	0.9	0.5	-1.0
Reaction time mean	0.0	0.0	0.0	-0.1	0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.0	-0.0
Median of all reaction times	0.1	0.1	0.1	-0.3	0.4
Reaction time omissions	0.7	1.0	1.2	-1.1	0.9
Reaction time false alarm rate	1.1	1.6	1.8	-1.2	1.3
Reaction time premature initiation rate	0.7	1.0	1.3	-1.1	0.8
Reaction time premature initiations	0.1	0.2	0.3	-0.6	0.0
Std. dev. reaction times	0.1	0.1	0.1	-0.4	0.2
Reaction time trials completed	0.4	0.6	0.9	0.5	-1.0
Reaction time trials AUC	0.3	0.5	0.7	0.4	-0.9
Social response proportion	0.3	0.3	0.5	-0.7	0.3
Social responses	0.2	0.3	0.4	-0.6	0.4
Social time	0.0	0.0	0.0	-0.1	0.1
Conditioned locomotion	0.2	0.2	0.3	-0.5	0.4
Cocaine response after cond. corrected	1.7	1.9	2.1	-1.4	1.3
Cocaine response after cond. not corrected	3.1	3.5	3.5	-1.9	1.8
Cocaine response before conditioning	1.0	1.3	1.6	-1.0	1.3
Saline control response	0.8	1.0	1.4	-1.2	0.8
Condit. Reinf. active minus inactive responses	0.9	1.1	1.6	-1.3	0.8
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.8	0.4
Condit. Reinf. active responses	1.4	2.0	2.4	-1.6	1.3
Condit. Reinf. inactive responses	2.9	3.6	3.6	-1.9	1.9
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.6	0.2
Condit. Reinf. lever reinforcers received	1.4	1.9	2.4	-1.5	1.2
Pavlov. Cond. lever latency	0.3	0.3	0.5	0.7	-0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.3
Pavlov. Cond. change in total contacts	0.7	0.9	1.3	-1.1	0.7
Pavlov. Cond. index score	0.1	0.2	0.3	-0.5	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.2
Pavlov. Cond. lever contacts	0.9	1.2	1.6	-1.3	0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.6	-0.3
Pavlov. Cond. intertrial magazine entries	1.3	1.7	1.7	1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.4	0.2
Pavlov. Cond. response bias	1.0	1.4	1.9	-1.4	1.0
Conditioned reinforcement - actives	2.3	2.3	2.3	-1.5	1.5
Conditioned reinforcement - inactives	2.3	2.6	2.8	-1.7	1.6
Conditioned locomotion	1.9	2.2	2.4	-1.5	1.5
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.3	0.5
Intermittent access intake escalation	0.1	0.1	0.1	-0.3	0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	0.5	-0.4
Intermitt. access day 1 inactive lever presses	1.6	1.8	1.8	-1.3	1.3
Intermitt. access day 15 inactive lever presses	2.8	3.0	3.2	-1.8	1.7
Intermitt. access escalation Index	0.7	0.6	0.7	0.8	-0.8
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.4
Intermittent access day 15 total infusions	0.3	0.3	0.3	-0.5	0.6
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.4	-0.5	0.6
Intermittent access total infusions	0.0	0.0	0.1	-0.2	0.2
Intermittent access day 1 locomotion	0.4	0.4	0.5	-0.5	0.7
Intermittent access day 15 total locomotion	0.4	0.4	0.7	-0.4	0.8
Intermittent access total locomotion	0.8	0.9	1.0	-0.9	1.0
Intermittent access standard deviation	0.2	0.2	0.2	-0.3	0.5
Cocaine induced anxiety	2.5	2.9	3.1	1.8	-1.6
Post-drug Anxiety	0.0	0.0	0.0	0.1	-0.1
Baseline Anxiety	4.4	4.6	5.4	-2.3	2.0
Lifetime Intake	0.0	0.0	0.0	-0.1	0.2
Incentive Sensitization - Responses	0.9	0.9	0.9	-1.0	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	0.8	-0.9	0.9
Progressive ratio test 1 active lever presses	1.1	1.2	1.2	-1.1	1.1
Progressive ratio test 1 breakpoint	1.3	1.3	1.4	-1.2	1.1
Progressive ratio test 1 inactive lever presses	1.7	1.8	2.0	-1.4	1.2
Progressive ratio test 2 active lever presses	1.1	1.1	1.1	-1.1	1.1
Progressive ratio test 2 breakpoint	0.8	0.9	1.0	-0.9	1.0
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.0	0.1
Total sessions with >9 infusions	0.7	0.7	0.8	-0.8	0.9
Short access day 1 total inactive lever presses	2.1	2.4	2.6	-1.5	1.6
Short access day 10 total inactive lever presses	0.2	0.2	0.3	0.2	-0.6
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	0.5
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.3
Short access total infusions	0.0	0.0	0.0	0.2	0.0
Short access day 1 locomotion	2.1	2.2	2.4	-1.5	1.5
Short access day 10 total locomotion	1.9	2.1	2.4	-1.3	1.6
Short access total locomotion	0.7	0.7	0.8	-0.7	0.9
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.0
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.2	0.4
One hour access (shock baseline)	0.3	0.3	0.3	-0.5	0.6
Number of responses in last shaping day	0.2	0.2	0.3	0.5	-0.4
Context. condit. distance diff. score	0.5	0.6	0.7	0.8	-0.7
Locomotion velocity, session 1	0.8	0.9	1.1	0.8	-1.0
Locomotion distance, session 1	3.2	4.1	4.8	1.8	-2.2
Locomotion velocity, session 2	0.9	1.0	1.0	1.0	-1.0
Locomotion distance, session 2	1.0	1.4	1.7	1.1	-1.3
Locomotion velocity, session 3	0.0	0.1	0.1	0.1	-0.3
Locomotion distance, session 3	0.6	0.7	0.8	0.8	-0.9
Stereotopy head waving bouts, day 3	3.5	4.2	4.7	-1.9	2.2
Stereotopy head waving duration, day 3	0.7	0.8	1.0	-0.8	1.0
Locomotion velocity, session 7	0.3	0.3	0.5	0.4	-0.7
Locomotion distance, session 7	0.0	0.0	0.0	0.1	-0.2
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	-0.7	0.9
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.2	0.3
Locomotion velocity, session 8	6.4	7.6	7.9	2.7	-2.8
Locomotion distance, session 8	1.7	2.5	2.8	1.5	-1.7
Degree of sensitization distance	0.1	0.1	0.1	0.3	-0.3
Degree of sensitization stereotypy	1.1	1.2	1.4	-1.0	1.2
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.1	-0.9	1.1
Condit. Reinf. active responses	0.5	0.7	0.7	-0.8	0.8
Condit. Reinf. inactive responses	0.5	0.6	0.7	-0.8	0.7
Incentive salience index mean	1.3	1.6	1.6	-1.3	1.3
Condit. Reinf. lever presses	1.2	1.6	1.8	-1.3	1.2
Time in familiar zone, hab. session 1	0.5	0.5	0.7	-0.5	0.9
Time in novel zone, hab. session 1	0.8	0.8	1.0	-1.0	0.8
Total zone transitions, hab. session 1	2.1	3.0	3.5	1.6	-1.9
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.5	0.7	0.6	-0.8
Time in familiar zone, hab. session 2	0.6	0.6	0.8	-0.7	0.9
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.3	0.1
Total zone transitions, hab. session 2	0.5	0.6	0.7	0.8	-0.8
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.0	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.3	-0.4
Novel to familiar place preference ratio	2.1	2.2	2.4	1.6	-1.4
Novelty place preference	1.3	1.4	1.6	1.3	-1.1
Time in novel zone, NPP test	0.4	0.5	0.6	0.8	-0.6
Total zone transitions, NPP test	0.2	0.3	0.4	0.4	-0.6
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.3	0.1
Locomotion velocity, NPP test	0.2	0.2	0.3	0.3	-0.6
Pavlov. Cond. lever latency	3.5	4.5	5.0	2.2	-2.0
Pavlov. Cond. magazine entry latency	9.9	12.8	13.1	-3.5	3.6
Pavlov. Cond. change in total contacts	6.9	7.3	7.7	-2.6	2.8
Pavlov. Cond. index score	8.8	11.2	11.5	-3.4	3.3
Pavlov. Cond. latency score	6.8	8.7	9.0	-3.0	2.9
Pavlov. Cond. lever contacts	2.9	3.5	3.8	-2.0	1.8
Pavlov. Cond. magazine entry number	12.1	15.1	15.2	3.9	-3.9
Pavlov. Cond. intertrial magazine entries	1.6	2.0	2.0	1.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	9.9	12.5	12.6	-3.6	3.5
Pavlov. Cond. response bias	9.9	12.1	12.4	-3.5	3.4
Bone: apparent density	1.5	2.5	2.7	-1.6	1.6
Bone surface	0.0	0.1	0.1	0.3	-0.3
Bone volume	0.0	0.0	0.0	-0.1	0.1
Bone: connectivity density	2.3	3.7	3.8	-1.9	1.9
Bone: cortical apparent density	4.3	5.5	6.1	-2.2	2.5
Bone: cortical area	0.1	0.2	0.2	-0.4	0.4
Bone: cortical porosity	1.1	1.2	1.4	-1.2	1.0
Bone: cortical porosity	1.6	1.8	2.1	-1.4	1.2
Bone: cortical thickness	1.0	1.6	1.8	-1.2	1.3
Bone: cortical thickness	4.9	5.8	5.9	-2.4	2.4
Bone: cortical tissue density	4.3	5.5	6.1	-2.2	2.5
Bone: elastic displacement	0.0	0.0	0.1	-0.3	0.1
Bone: elastic work	0.0	0.0	0.0	-0.0	-0.1
Bone: endosteal estimation	1.7	3.6	3.7	1.9	-1.9
Bone: endosteal perimeter	1.4	3.0	3.3	1.6	-1.8
Bone: final force	1.1	1.9	2.0	-1.3	1.4
Bone: final moment	1.0	1.6	1.7	-1.2	1.3
Bone: marrow area	1.6	3.4	3.5	1.8	-1.9
Bone: maximum diameter	0.0	0.0	0.0	-0.0	0.1
Bone: maximum force	0.0	0.1	0.1	-0.1	0.3
Bone: maximum moment	0.0	0.0	0.1	-0.1	0.2
Bone: minimum diameter	0.4	0.7	0.8	0.9	-0.8
Bone: periosteal estimation	0.1	0.3	0.3	0.5	-0.5
Bone: periosteal perimeter	0.5	0.9	0.9	0.9	-1.0
Bone: post-yield work	0.8	1.1	1.2	1.1	-1.0
Bone: stiffness	0.1	0.1	0.1	-0.2	0.4
Bone: tissue strength	0.7	0.6	0.8	0.9	-0.7
Bone: trabecular number	4.4	6.8	7.1	-2.5	2.7
Bone: trabecular spacing	0.5	0.6	0.7	0.7	-0.8
Bone: trabecular thickness	0.0	0.0	0.0	0.0	-0.1
Bone: trabecular tissue density	0.0	0.0	0.1	-0.2	0.1
Breakpoint value in progressive ratio session	0.8	0.9	1.0	1.0	-0.9
Distance traveled before self-admin	0.0	0.0	0.1	-0.2	-0.0
Distance traveled after self-admin	1.2	1.3	1.4	1.2	-1.1
Delta time in closed arm before/after self-admin	3.3	3.2	3.3	1.8	-1.8
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.4	0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0
Extinction: sum of active levers before priming	0.8	0.8	1.1	1.1	-0.7
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	0.5
Delta distance traveled before/after self-admin	1.4	1.5	1.8	1.3	-1.1
Delta ambulatory time before/after self-admin	0.3	0.4	0.5	0.7	-0.5
Time in closed arm before self-admin	1.8	2.1	2.6	-1.6	1.2
Time in closed arm after self-admin	0.4	0.5	0.6	0.5	-0.8
Time in open arm before self-admin	3.1	3.3	3.3	1.8	-1.8
Time in open arm after self-admin	0.3	0.3	0.3	0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.3	0.2	0.5	-0.2	0.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.2	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.2	0.2
Time to tail flick, test, before self-admin	0.5	0.5	0.7	0.8	-0.6
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.5	0.6
Delta time to tail flick, test, before/after SA	1.1	1.0	1.0	-1.0	1.0
Ambulatory time before self-admin	0.1	0.1	0.1	0.2	-0.4
Ambulatory time after self-admin	2.7	3.0	3.0	1.7	-1.7
Total heroin consumption	0.1	0.1	0.1	-0.0	0.4
Area under the delay curve	0.9	1.0	1.2	-0.9	1.1
Delay disc. indifference point, 0s delay	1.5	1.6	1.7	-1.2	1.3
Delay disc. indifference point, 16s delay	0.6	0.6	0.7	-0.7	0.8
Delay disc. indifference point, 2s delay	2.6	2.9	3.0	-1.7	1.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	0.4	-0.7	0.6
Delay disc. indifference point, 8s delay	1.0	1.1	1.3	-0.9	1.2
Delay discount exponential model param	0.4	0.4	0.6	0.5	-0.8
Delay discount hyperbolic model param	0.7	0.7	0.9	0.7	-1.0
Fecal boli incidents, locomotor time 1	0.3	0.4	0.4	0.6	-0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.3	0.6
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.0	-0.9	1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.3	-0.4
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.4	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.5	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.2	0.3
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.5	-0.1
Time >=10cm from walls, locomotor time 2	2.0	2.2	2.3	-1.4	1.5
Bouts of movement, locomotor time 2	0.3	0.4	0.4	-0.7	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.6	0.4
Rest time, locomotor task time 2	0.6	0.7	0.8	0.8	-0.9
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	-0.0
Weight adjusted by age	0.2	0.3	0.3	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.1	-0.1
Locomotion in novel chamber	1.7	2.2	2.8	-1.2	1.7
Locomotion in novel chamber post-restriction	0.6	0.7	0.8	-0.9	0.8
Progressive ratio	0.1	0.1	0.2	-0.4	0.1
Food seeking constrained by brief footshock	0.2	0.2	0.2	-0.4	0.5
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.1	0.3
Run reversals in cocaine runway, females	2.0	1.9	2.1	1.5	-1.3
Run reversals in cocaine runway, males	0.5	0.5	0.5	-0.7	0.7
Latency to leave start box in cocaine runway	2.8	3.1	3.5	1.6	-1.9
Latency to leave start box in cocaine runway, F	2.2	2.4	3.0	1.3	-1.7
Latency to leave start box in cocaine runway, M	0.7	0.7	0.9	1.0	-0.7
Cd content in liver	0.1	0.1	0.2	-0.2	0.5
Co content in liver	1.5	1.7	1.8	1.3	-1.3
Cu content in liver	0.9	1.1	1.2	1.0	-1.1
Fe content in liver	1.5	1.8	1.9	1.3	-1.4
K content in liver	0.1	0.1	0.1	-0.3	0.3
Mg content in liver	0.1	0.2	0.2	-0.4	0.4
Mn content in liver	0.3	0.3	0.4	-0.6	0.6
Na content in liver	0.2	0.2	0.2	-0.5	0.4
Rb content in liver	1.5	1.9	2.2	-1.5	1.3
Se content in liver	1.8	2.1	2.2	-1.4	1.5
Sr content in liver	0.2	0.2	0.3	0.5	-0.4
Zn content in liver	2.4	2.6	3.1	-1.8	1.5