Hub : Traits

Seeking ratio, delayed vs. immediate footshock

Ratio of seeking under delayed versus immediate brief footshock punishment

Tags: Behavior · Motivation

Project: u01_tom_jhou

4 loci · 4 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	68581504	69974370	1	1	5.66e-09	8.87e-02	1.34e-09	Syt5
2	2	90636696	92031287	1	1	3.55e-07	3.14e-04	3.08e-01	Snx16
3	3	144954411	146337971	1	1	2.33e-07	1.92e-04	6.84e-01	Ndrg3
4	5	74868378	76264539	1	1	1.82e-07	5.22e-03	1.98e-01	RGD1566134

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.94	1	0	0	0	1.00e+00	Snx16
BMI without tail	22.63	1	1	25	0	1.00e+00	Snx16
Body weight	3.02	3	0	0	0	1.00e+00	Snx16 Syt5 RGD1566134
Glucose	12.08	1	0	0	0	1.00e+00	Syt5
Right kidney weight	2.57	1	0	0	0	1.00e+00	Syt5
Tail length	14.44	1	1	25	0	1.00e+00	Snx16
Length with tail	2.62	1	0	0	0	1.00e+00	Snx16
Length without tail	3.25	1	0	0	0	1.00e+00	Syt5
Liver weight, left	10.21	1	0	0	0	1.00e+00	Syt5
Liver weight, right	11.2	1	0	0	0	1.00e+00	Syt5
Parametrial fat weight	5.08	1	0	0	0	1.00e+00	Ndrg3
Intraocular pressure	5.47	1	0	0	0	1.00e+00	Snx16
Extensor digitorum longus weight	8.22	1	1	25	0	1.00e+00	Snx16
Tibialis anterior weight	5.24	2	1	25	0	1.00e+00	Snx16 Syt5
Tibia length	7.53	1	0	0	0	1.00e+00	Syt5
Food consumed during 24 hour testing period	5.75	1	0	0	0	1.00e+00	RGD1566134
Std. dev. time between licks in bursts	22.72	1	1	25	0	1.00e+00	Syt5
Water consumed over 24 hours	9.14	1	0	0	0	1.00e+00	RGD1566134
Indifference point 0 sec	6.32	1	0	0	0	1.00e+00	Syt5
Indifference point AUC	16.61	1	0	0	0	1.00e+00	Snx16
Indifference point function ln k	8.79	1	0	0	0	1.00e+00	Syt5
Indifference point function log k	8.79	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 0 sec	5.75	1	0	0	0	1.00e+00	Syt5
Delay discounting total patch changes 18 sec	4.84	1	0	0	0	1.00e+00	Snx16
Delay discounting total patch changes 24 sec	9.59	2	0	0	0	1.00e+00	Syt5 RGD1566134
Delay discounting total patch changes 6 sec	5.27	2	0	0	0	1.00e+00	Snx16 RGD1566134
Delay discounting time to switch 0 sec	23.87	3	1	25	0	1.00e+00	Snx16 Syt5 RGD1566134
Delay discounting water rate 0 sec	10.34	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 12 sec	22.12	1	1	25	0	1.00e+00	Syt5
Delay discounting water rate 18 sec	19.1	1	0	0	0	1.00e+00	Syt5
Delay discounting water rate 24 sec	7.99	1	0	0	0	1.00e+00	Syt5
Light reinforcement 1	13.25	2	1	25	0	1.00e+00	Syt5 Ndrg3
Light reinforcement 2	21.57	1	1	25	0	1.00e+00	Syt5
Reaction time number correct	5.61	1	0	0	0	1.00e+00	Snx16
Reaction time mean minus median	5.82	1	0	0	0	1.00e+00	Snx16
Reaction time mean minus median AUC	6.13	1	0	0	0	1.00e+00	Snx16
Reaction time num false alarms	9	2	0	0	0	1.00e+00	Snx16 Ndrg3
Reaction time num false alarms AUC	9.25	2	0	0	0	1.00e+00	Syt5 Ndrg3
Reaction time trials correct on left	5.61	1	0	0	0	1.00e+00	Snx16
Reaction time trials on left	5.27	1	0	0	0	1.00e+00	Snx16
Reaction time mean	5.11	1	0	0	0	1.00e+00	Syt5
Reaction time mean AUC	6.17	1	0	0	0	1.00e+00	Syt5
Median of all reaction times	6.98	1	0	0	0	1.00e+00	Syt5
Reaction time omissions	6.27	2	0	0	0	1.00e+00	Snx16 Syt5
Reaction time false alarm rate	4.75	2	0	0	0	1.00e+00	Syt5 Ndrg3
Std. dev. reaction times	7.62	1	0	0	0	1.00e+00	Snx16
Reaction time trials completed	5.27	1	0	0	0	1.00e+00	Snx16
Reaction time trials AUC	6.19	1	0	0	0	1.00e+00	Snx16
Social response proportion	7.98	1	0	0	0	1.00e+00	Syt5
Social responses	8.27	1	0	0	0	1.00e+00	Snx16
Social time	18.13	1	0	0	0	1.00e+00	Syt5
Conditioned locomotion	5.97	2	0	0	0	1.00e+00	Syt5 RGD1566134
Cocaine response after cond. corrected	18.2	1	0	0	0	1.00e+00	Syt5
Cocaine response after cond. not corrected	16.42	1	0	0	0	1.00e+00	Syt5
Saline control response	15.22	2	0	0	0	1.00e+00	Syt5 RGD1566134
Condit. Reinf. active minus inactive responses	5.59	1	0	0	0	1.00e+00	Ndrg3
Condit. Reinf. lever presses	12.12	2	0	0	0	1.00e+00	Syt5 RGD1566134
Pavlov. Cond. lever latency	29.43	1	1	25	0	1.00e+00	RGD1566134
Pavlov. Cond. magazine entry latency	14.11	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. change in total contacts	11.04	2	0	0	0	1.00e+00	Syt5 RGD1566134
Pavlov. Cond. index score	22.35	1	1	25	0	1.00e+00	RGD1566134
Pavlov. Cond. latency score	25.6	1	1	25	0	1.00e+00	RGD1566134
Pavlov. Cond. lever contacts	19.06	1	1	25	0	1.00e+00	RGD1566134
Pavlov. Cond. magazine entry number	18.05	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. lever-magazine prob. diff.	19.7	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. response bias	20.37	1	1	25	0	1.00e+00	RGD1566134
Conditioned reinforcement - actives	22.28	1	0	0	0	1.00e+00	Syt5
Conditioned locomotion	15.14	1	0	0	0	1.00e+00	Syt5
Intermittent access intake day 1-15 change	10.86	2	0	0	0	1.00e+00	Snx16 Syt5
Intermittent access intake escalation	12.85	1	0	0	0	1.00e+00	Snx16
Intermittent access intake escalation 2	28.12	1	1	25	0	1.00e+00	Snx16
Intermitt. access day 1 inactive lever presses	19.07	1	0	0	0	1.00e+00	Syt5
Intermitt. access day 15 inactive lever presses	38.52	1	1	25	0	1.00e+00	Syt5
Intermitt. access escalation Index	17.22	1	0	0	0	1.00e+00	Syt5
Intermittent access day 1 total infusions	34.15	1	1	25	0	1.00e+00	RGD1566134
Intermittent access terminal intake (last 3 days)	6.27	1	0	0	0	1.00e+00	Snx16
Intermittent access standard deviation	14.56	2	0	0	0	1.00e+00	Snx16 Syt5
Cocaine induced anxiety	13.98	1	0	0	0	1.00e+00	Snx16
Post-drug Anxiety	21.2	2	1	25	0	1.00e+00	Snx16 Syt5
Baseline Anxiety	21.82	2	1	25	0	1.00e+00	Syt5 RGD1566134
Lifetime Intake	24.67	1	1	25	0	1.00e+00	RGD1566134
Incentive Sensitization - Responses	6.78	1	0	0	0	1.00e+00	Syt5
Incentive Sensitization - Breakpoint	8.61	1	0	0	0	1.00e+00	Syt5
Progressive ratio test 1 active lever presses	8.65	2	0	0	0	1.00e+00	Snx16 RGD1566134
Progressive ratio test 1 breakpoint	9.59	1	0	0	0	1.00e+00	RGD1566134
Progressive ratio test 2 active lever presses	14.44	1	0	0	0	1.00e+00	RGD1566134
Progressive ratio test 2 breakpoint	14.96	1	0	0	0	1.00e+00	RGD1566134
Total sessions with >9 infusions	15.08	1	0	0	0	1.00e+00	RGD1566134
Short access day 1 total inactive lever presses	15.26	2	1	25	0	1.00e+00	Syt5 Ndrg3
Short access day 1 total infusions	21.77	1	0	0	0	1.00e+00	RGD1566134
Short access day 10 total infusions	18.58	1	0	0	0	1.00e+00	RGD1566134
Short access total infusions	56.6	1	1	25	0	1.00e+00	RGD1566134
Short access day 1 locomotion	9.09	2	0	0	0	1.00e+00	Ndrg3 RGD1566134
Short access day 10 total locomotion	11.18	1	0	0	0	1.00e+00	Syt5
Short access total locomotion	13.05	1	0	0	0	1.00e+00	Syt5
Compulsive drug intake	10.06	2	0	0	0	1.00e+00	Ndrg3 RGD1566134
One hour access (shock baseline)	24.39	1	1	25	0	1.00e+00	Syt5
Number of responses in last shaping day	9.84	1	0	0	0	1.00e+00	Syt5
Context. condit. distance diff. score	6.72	1	0	0	0	1.00e+00	RGD1566134
Locomotion velocity, session 1	61.51	1	1	25	0	1.00e+00	Syt5
Locomotion distance, session 1	22.42	1	1	25	0	1.00e+00	Syt5
Locomotion velocity, session 2	20.55	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 2	5.4	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 3	8.71	1	0	0	0	1.00e+00	Syt5
Stereotopy head waving bouts, day 3	6.63	1	0	0	0	1.00e+00	RGD1566134
Stereotopy head waving duration, day 3	15.72	1	0	0	0	1.00e+00	RGD1566134
Locomotion velocity, session 7	5.99	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 7	10.24	1	0	0	0	1.00e+00	Syt5
Stereotopy head waving bouts, day 7	26.39	1	1	25	0	1.00e+00	RGD1566134
Stereotopy head waving duration, day 7	17.8	1	0	0	0	1.00e+00	RGD1566134
Locomotion velocity, session 8	15.73	1	0	0	0	1.00e+00	Syt5
Locomotion distance, session 8	9.21	1	0	0	0	1.00e+00	Syt5
Degree of sensitization stereotypy	16.12	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. active minus inactive responses	11.45	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. active responses	13.25	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. inactive responses	8.3	1	0	0	0	1.00e+00	RGD1566134
Incentive salience index mean	10.53	1	0	0	0	1.00e+00	RGD1566134
Condit. Reinf. lever presses	5.81	1	0	0	0	1.00e+00	RGD1566134
Time in familiar zone, hab. session 1	12.58	2	0	0	0	1.00e+00	Snx16 Syt5
Total zone transitions, hab. session 1	25.53	1	1	25	0	1.00e+00	Syt5
Total locomotion distance, hab. session 1	19.26	1	1	25	0	1.00e+00	Syt5
Locomotion velocity, hab. session 1	12.27	1	0	0	0	1.00e+00	Syt5
Time in familiar zone, hab. session 2	10.09	2	0	0	0	1.00e+00	Snx16 Syt5
Total zone transitions, hab. session 2	7.86	1	0	0	0	1.00e+00	Syt5
Total locomotion distance, hab. session 2	8.58	2	0	0	0	1.00e+00	Syt5 RGD1566134
Locomotion velocity, hab. session 2	10.58	2	0	0	0	1.00e+00	Syt5 RGD1566134
Novel to familiar place preference ratio	9.29	1	0	0	0	1.00e+00	Ndrg3
Novelty place preference	10.06	1	0	0	0	1.00e+00	Ndrg3
Time in novel zone, NPP test	10.31	1	0	0	0	1.00e+00	Ndrg3
Total locomotion distance, NPP test	5.32	1	0	0	0	1.00e+00	Ndrg3
Locomotion velocity, NPP test	6.51	1	0	0	0	1.00e+00	Ndrg3
Pavlov. Cond. lever latency	5.53	1	0	0	0	1.00e+00	RGD1566134
Pavlov. Cond. magazine entry latency	10.45	1	0	0	0	1.00e+00	Syt5
Pavlov. Cond. intertrial magazine entries	13	2	0	0	0	1.00e+00	Syt5 RGD1566134
Pavlov. Cond. response bias	13.37	1	0	0	0	1.00e+00	Syt5
Bone: apparent density	11.64	1	0	0	0	1.00e+00	RGD1566134
Bone surface	14.55	1	0	0	0	1.00e+00	RGD1566134
Bone volume	11.62	1	0	0	0	1.00e+00	RGD1566134
Bone: cortical apparent density	5.36	1	0	0	0	1.00e+00	RGD1566134
Bone: cortical porosity	7.72	1	0	0	0	1.00e+00	Syt5
Bone: cortical tissue density	5.24	1	0	0	0	1.00e+00	RGD1566134
Bone: elastic displacement	7.66	1	0	0	0	1.00e+00	Syt5
Bone: elastic work	5.83	1	0	0	0	1.00e+00	Syt5
Bone: endosteal estimation	4.1	2	0	0	0	1.00e+00	Snx16 RGD1566134
Bone: endosteal perimeter	6.97	1	0	0	0	1.00e+00	RGD1566134
Bone: marrow area	4.23	2	0	0	0	1.00e+00	Snx16 RGD1566134
Bone: maximum diameter	7.17	1	0	0	0	1.00e+00	RGD1566134
Bone: minimum diameter	7.56	1	0	0	0	1.00e+00	Snx16
Bone: periosteal estimation	4.43	1	0	0	0	1.00e+00	Snx16
Bone: post-yield work	11.59	1	0	0	0	1.00e+00	Syt5
Bone: stiffness	4.47	1	0	0	0	1.00e+00	Syt5
Bone: tissue strength	13.13	1	0	0	0	1.00e+00	Syt5
Bone: trabecular thickness	10.89	1	0	0	0	1.00e+00	RGD1566134
Bone: trabecular tissue density	8.22	1	0	0	0	1.00e+00	Syt5
Distance traveled before self-admin	37.26	2	1	25	0	1.00e+00	Snx16 Syt5
Distance traveled after self-admin	31.98	2	1	25	0	1.00e+00	Snx16 Syt5
Delta time in closed arm before/after self-admin	8.57	1	0	0	0	1.00e+00	Snx16
Delta time in open arm before/after self-admin	18.04	1	0	0	0	1.00e+00	Syt5
Diff in mean of infusions in LGA sessions	15.12	2	0	0	0	1.00e+00	Snx16 Syt5
Extinction: sum of active levers before priming	36.46	1	1	25	0	1.00e+00	Syt5
Active lever presses in extinction session 6	11.25	3	0	0	0	1.00e+00	Snx16 Syt5 RGD1566134
Time in closed arm after self-admin	22.26	1	0	0	0	1.00e+00	Syt5
Time in open arm before self-admin	16.54	1	0	0	0	1.00e+00	Ndrg3
Time in open arm after self-admin	17.09	1	0	0	0	1.00e+00	Syt5
Sum of active levers in priming session hrs 5-6	17.22	1	0	0	0	1.00e+00	Syt5
Time to tail flick, vehicle, before self-admin	9.86	1	0	0	0	1.00e+00	Snx16
Time to tail flick, test, before self-admin	38.89	2	1	25	0	1.00e+00	Snx16 Syt5
Delta time to tail flick, vehicle, before/after SA	8.61	1	0	0	0	1.00e+00	Syt5
Delta time to tail flick, test, before/after SA	42.42	1	1	25	0	1.00e+00	Syt5
Ambulatory time before self-admin	36.65	1	1	25	0	1.00e+00	Syt5
Ambulatory time after self-admin	61.31	1	1	25	0	1.00e+00	Syt5
Total heroin consumption	5.77	1	0	0	0	1.00e+00	Syt5
Delay disc. indifference point, 0s delay	18.05	2	1	25	0	1.00e+00	Syt5 RGD1566134
Delay disc. indifference point, 16s delay	24.13	1	0	0	0	1.00e+00	Syt5
Delay disc. indifference point, 24s delay	9.61	1	0	0	0	1.00e+00	Syt5
Delay disc. indifference point, 4s delay	23.4	1	0	0	0	1.00e+00	RGD1566134
Delay disc. indifference point, 8s delay	8.44	2	0	0	0	1.00e+00	Snx16 Ndrg3
Fecal boli incidents, locomotor time 1	7.47	1	0	0	0	1.00e+00	Snx16
Time >=10cm from walls, locomotor time 1	13.93	1	0	0	0	1.00e+00	Snx16
Bouts of movement, locomotor time 1	33.72	2	1	25	0	1.00e+00	Snx16 Syt5
Total resting periods, locomotor time 1	37.3	1	1	25	0	1.00e+00	Syt5
Vertical activity count, locomotor time 1	24.22	1	0	0	0	1.00e+00	Syt5
Time >=10cm from walls, locomotor time 2	14.74	1	0	0	0	1.00e+00	RGD1566134
Rest time, locomotor task time 2	9.12	1	0	0	0	1.00e+00	Syt5
Weight adjusted by age	23.46	4	2	50	0.23	7.75e-01	Snx16 Syt5 Ndrg3 RGD1566134
Locomotion in novel chamber	10.56	2	0	0	0	1.00e+00	Syt5 Ndrg3
Progressive ratio	10.23	2	0	0	0	1.00e+00	Syt5 Ndrg3
Food seeking constrained by brief footshock	75.06	2	1	25	0	1.00e+00	Snx16 Syt5
Seeking ratio, punishment vs. effort	13.54	2	0	0	0	1.00e+00	Syt5 Ndrg3
Run reversals in cocaine runway, females	9.7	2	0	0	0	1.00e+00	Syt5 RGD1566134
Cd content in liver	7.7	1	0	0	0	1.00e+00	Syt5
Co content in liver	19.37	1	0	0	0	1.00e+00	Syt5
Fe content in liver	8.75	1	0	0	0	1.00e+00	RGD1566134
Na content in liver	15.71	1	0	0	0	1.00e+00	RGD1566134
Rb content in liver	5.88	2	0	0	0	1.00e+00	Syt5 RGD1566134
Sr content in liver	66.74	1	1	25	0	1.00e+00	Syt5
Zn content in liver	13.74	2	0	0	0	1.00e+00	Syt5 RGD1566134

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.08
Adipose	alternative TSS	0	0	1.06
Adipose	gene expression	1	0	1.13
Adipose	isoform ratio	0	0	1.12
Adipose	intron excision ratio	0	0	1.19
Adipose	mRNA stability	0	0	1.13
BLA	alternative polyA	0	0	1.06
BLA	alternative TSS	0	0	1.09
BLA	gene expression	0	0	1.16
BLA	isoform ratio	0	0	1.22
BLA	intron excision ratio	0	0	1.06
BLA	mRNA stability	1	0	1.16
Brain	alternative polyA	0	0	1.05
Brain	alternative TSS	0	0	1.14
Brain	gene expression	0	0	1.18
Brain	isoform ratio	0	0	1.18
Brain	intron excision ratio	0	0	1.12
Brain	mRNA stability	0	0	1.11
Eye	alternative polyA	0	0	0.88
Eye	alternative TSS	0	0	1.17
Eye	gene expression	0	0	1.07
Eye	isoform ratio	0	0	1.23
Eye	intron excision ratio	0	0	1.26
Eye	mRNA stability	0	0	1.57
IL	alternative polyA	0	0	1.14
IL	alternative TSS	0	0	1.33
IL	gene expression	0	0	1.15
IL	isoform ratio	0	0	1.18
IL	intron excision ratio	0	0	1.08
IL	mRNA stability	0	0	1.19
LHb	alternative polyA	0	0	1.01
LHb	alternative TSS	0	0	1.4
LHb	gene expression	0	0	1.22
LHb	isoform ratio	0	0	1.15
LHb	intron excision ratio	0	0	1.14
LHb	mRNA stability	0	0	1.21
Liver	alternative polyA	0	0	1.1
Liver	alternative TSS	0	0	1.18
Liver	gene expression	0	0	1.12
Liver	isoform ratio	0	0	1.15
Liver	intron excision ratio	1	0	1.15
Liver	mRNA stability	0	0	1.12
NAcc	alternative polyA	0	0	1.1
NAcc	alternative TSS	0	0	1.28
NAcc	gene expression	0	0	1.21
NAcc	isoform ratio	0	0	1.19
NAcc	intron excision ratio	0	0	1.13
NAcc	mRNA stability	0	0	1.19
OFC	alternative polyA	0	0	0.99
OFC	alternative TSS	0	0	1.32
OFC	gene expression	0	0	1.15
OFC	isoform ratio	0	0	1.19
OFC	intron excision ratio	0	0	1.05
OFC	mRNA stability	0	0	1.15
PL	alternative polyA	0	0	1.03
PL	alternative TSS	0	0	1.25
PL	gene expression	0	0	1.16
PL	isoform ratio	0	0	1.19
PL	intron excision ratio	1	0	1.14
PL	mRNA stability	0	0	1.17