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Seeking ratio, delayed vs. immediate footshock

Ratio of seeking under delayed versus immediate brief footshock punishment

Tags: Behavior · Motivation

Project: u01_tom_jhou

4 significantly associated models · 4 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 68581504 69974370 1 1 5.7e-09 0.08874 1.3e-09 -1169 Syt5
2 2 90636696 92031287 1 1 3.6e-07 0.00031 3.1e-01 92 Snx16
3 3 144954411 146337971 1 1 2.3e-07 0.00019 6.8e-01 99 Ndrg3
4 5 74868378 76264539 1 1 1.8e-07 0.00522 2.0e-01 79 RGD1566134

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.9 1 0 0 0.00 1.00 Snx16
BMI without tail 22.6 1 1 25 0.00 1.00 Snx16
Body weight 3.0 3 0 0 0.00 1.00 Snx16 Syt5 RGD1566134
Glucose 12.1 1 0 0 0.00 1.00 Syt5
Right kidney weight 2.6 1 0 0 0.00 1.00 Syt5
Tail length 14.4 1 1 25 0.00 1.00 Snx16
Length with tail 2.6 1 0 0 0.00 1.00 Snx16
Length without tail 3.2 1 0 0 0.00 1.00 Syt5
Liver weight, left 10.2 1 0 0 0.00 1.00 Syt5
Liver weight, right 11.2 1 0 0 0.00 1.00 Syt5
Parametrial fat weight 5.1 1 0 0 0.00 1.00 Ndrg3
Intraocular pressure 5.5 1 0 0 0.00 1.00 Snx16
Extensor digitorum longus weight 8.2 1 1 25 0.00 1.00 Snx16
Tibialis anterior weight 5.2 2 1 25 0.00 1.00 Snx16 Syt5
Tibia length 7.5 1 0 0 0.00 1.00 Syt5
Food consumed during 24 hour testing period 5.8 1 0 0 0.00 1.00 RGD1566134
Std. dev. time between licks in bursts 22.7 1 1 25 0.00 1.00 Syt5
Water consumed over 24 hours 9.1 1 0 0 0.00 1.00 RGD1566134
Indifference point 0 sec 6.3 1 0 0 0.00 1.00 Syt5
Indifference point AUC 16.6 1 0 0 0.00 1.00 Snx16
Indifference point function ln k 8.8 1 0 0 0.00 1.00 Syt5
Indifference point function log k 8.8 1 0 0 0.00 1.00 Syt5
Delay discounting total patch changes 0 sec 5.8 1 0 0 0.00 1.00 Syt5
Delay discounting total patch changes 18 sec 4.8 1 0 0 0.00 1.00 Snx16
Delay discounting total patch changes 24 sec 9.6 2 0 0 0.00 1.00 Syt5 RGD1566134
Delay discounting total patch changes 6 sec 5.3 2 0 0 0.00 1.00 Snx16 RGD1566134
Delay discounting time to switch 0 sec 23.9 3 1 25 0.00 1.00 Snx16 Syt5 RGD1566134
Delay discounting water rate 0 sec 10.3 1 0 0 0.00 1.00 Syt5
Delay discounting water rate 12 sec 22.1 1 1 25 0.00 1.00 Syt5
Delay discounting water rate 18 sec 19.1 1 0 0 0.00 1.00 Syt5
Delay discounting water rate 24 sec 8.0 1 0 0 0.00 1.00 Syt5
Light reinforcement 1 13.2 2 1 25 0.00 1.00 Syt5 Ndrg3
Light reinforcement 2 21.6 1 1 25 0.00 1.00 Syt5
Reaction time number correct 5.6 1 0 0 0.00 1.00 Snx16
Reaction time mean minus median 5.8 1 0 0 0.00 1.00 Snx16
Reaction time mean minus median AUC 6.1 1 0 0 0.00 1.00 Snx16
Reaction time num false alarms 9.0 2 0 0 0.00 1.00 Snx16 Ndrg3
Reaction time num false alarms AUC 9.2 2 0 0 0.00 1.00 Syt5 Ndrg3
Reaction time trials correct on left 5.6 1 0 0 0.00 1.00 Snx16
Reaction time trials on left 5.3 1 0 0 0.00 1.00 Snx16
Reaction time mean 5.1 1 0 0 0.00 1.00 Syt5
Reaction time mean AUC 6.2 1 0 0 0.00 1.00 Syt5
Median of all reaction times 7.0 1 0 0 0.00 1.00 Syt5
Reaction time omissions 6.3 2 0 0 0.00 1.00 Snx16 Syt5
Reaction time false alarm rate 4.8 2 0 0 0.00 1.00 Syt5 Ndrg3
Std. dev. reaction times 7.6 1 0 0 0.00 1.00 Snx16
Reaction time trials completed 5.3 1 0 0 0.00 1.00 Snx16
Reaction time trials AUC 6.2 1 0 0 0.00 1.00 Snx16
Social response proportion 8.0 1 0 0 0.00 1.00 Syt5
Social responses 8.3 1 0 0 0.00 1.00 Snx16
Social time 18.1 1 0 0 0.00 1.00 Syt5
Conditioned locomotion 6.0 2 0 0 0.00 1.00 Syt5 RGD1566134
Cocaine response after cond. corrected 18.2 1 0 0 0.00 1.00 Syt5
Cocaine response after cond. not corrected 16.4 1 0 0 0.00 1.00 Syt5
Saline control response 15.2 2 0 0 0.00 1.00 Syt5 RGD1566134
Condit. Reinf. active minus inactive responses 5.6 1 0 0 0.00 1.00 Ndrg3
Condit. Reinf. lever presses 12.1 2 0 0 0.00 1.00 Syt5 RGD1566134
Pavlov. Cond. lever latency 29.4 1 1 25 0.00 1.00 RGD1566134
Pavlov. Cond. magazine entry latency 14.1 1 0 0 0.00 1.00 RGD1566134
Pavlov. Cond. change in total contacts 11.0 2 0 0 0.00 1.00 Syt5 RGD1566134
Pavlov. Cond. index score 22.4 1 1 25 0.00 1.00 RGD1566134
Pavlov. Cond. latency score 25.6 1 1 25 0.00 1.00 RGD1566134
Pavlov. Cond. lever contacts 19.1 1 1 25 0.00 1.00 RGD1566134
Pavlov. Cond. magazine entry number 18.1 1 0 0 0.00 1.00 RGD1566134
Pavlov. Cond. lever-magazine prob. diff. 19.7 1 0 0 0.00 1.00 RGD1566134
Pavlov. Cond. response bias 20.4 1 1 25 0.00 1.00 RGD1566134
Conditioned reinforcement - actives 22.3 1 0 0 0.00 1.00 Syt5
Conditioned locomotion 15.1 1 0 0 0.00 1.00 Syt5
Intermittent access intake day 1-15 change 10.9 2 0 0 0.00 1.00 Snx16 Syt5
Intermittent access intake escalation 12.8 1 0 0 0.00 1.00 Snx16
Intermittent access intake escalation 2 28.1 1 1 25 0.00 1.00 Snx16
Intermitt. access day 1 inactive lever presses 19.1 1 0 0 0.00 1.00 Syt5
Intermitt. access day 15 inactive lever presses 38.5 1 1 25 0.00 1.00 Syt5
Intermitt. access escalation Index 17.2 1 0 0 0.00 1.00 Syt5
Intermittent access day 1 total infusions 34.1 1 1 25 0.00 1.00 RGD1566134
Intermittent access terminal intake (last 3 days) 6.3 1 0 0 0.00 1.00 Snx16
Intermittent access standard deviation 14.6 2 0 0 0.00 1.00 Snx16 Syt5
Cocaine induced anxiety 14.0 1 0 0 0.00 1.00 Snx16
Post-drug Anxiety 21.2 2 1 25 0.00 1.00 Snx16 Syt5
Baseline Anxiety 21.8 2 1 25 0.00 1.00 Syt5 RGD1566134
Lifetime Intake 24.7 1 1 25 0.00 1.00 RGD1566134
Incentive Sensitization - Responses 6.8 1 0 0 0.00 1.00 Syt5
Incentive Sensitization - Breakpoint 8.6 1 0 0 0.00 1.00 Syt5
Progressive ratio test 1 active lever presses 8.7 2 0 0 0.00 1.00 Snx16 RGD1566134
Progressive ratio test 1 breakpoint 9.6 1 0 0 0.00 1.00 RGD1566134
Progressive ratio test 2 active lever presses 14.4 1 0 0 0.00 1.00 RGD1566134
Progressive ratio test 2 breakpoint 15.0 1 0 0 0.00 1.00 RGD1566134
Total sessions with >9 infusions 15.1 1 0 0 0.00 1.00 RGD1566134
Short access day 1 total inactive lever presses 15.3 2 1 25 0.00 1.00 Syt5 Ndrg3
Short access day 1 total infusions 21.8 1 0 0 0.00 1.00 RGD1566134
Short access day 10 total infusions 18.6 1 0 0 0.00 1.00 RGD1566134
Short access total infusions 56.6 1 1 25 0.00 1.00 RGD1566134
Short access day 1 locomotion 9.1 2 0 0 0.00 1.00 Ndrg3 RGD1566134
Short access day 10 total locomotion 11.2 1 0 0 0.00 1.00 Syt5
Short access total locomotion 13.1 1 0 0 0.00 1.00 Syt5
Compulsive drug intake 10.1 2 0 0 0.00 1.00 Ndrg3 RGD1566134
One hour access (shock baseline) 24.4 1 1 25 0.00 1.00 Syt5
Number of responses in last shaping day 9.8 1 0 0 0.00 1.00 Syt5
Context. condit. distance diff. score 6.7 1 0 0 0.00 1.00 RGD1566134
Locomotion velocity, session 1 61.5 1 1 25 0.00 1.00 Syt5
Locomotion distance, session 1 22.4 1 1 25 0.00 1.00 Syt5
Locomotion velocity, session 2 20.6 1 0 0 0.00 1.00 Syt5
Locomotion distance, session 2 5.4 1 0 0 0.00 1.00 Syt5
Locomotion distance, session 3 8.7 1 0 0 0.00 1.00 Syt5
Stereotopy head waving bouts, day 3 6.6 1 0 0 0.00 1.00 RGD1566134
Stereotopy head waving duration, day 3 15.7 1 0 0 0.00 1.00 RGD1566134
Locomotion velocity, session 7 6.0 1 0 0 0.00 1.00 Syt5
Locomotion distance, session 7 10.2 1 0 0 0.00 1.00 Syt5
Stereotopy head waving bouts, day 7 26.4 1 1 25 0.00 1.00 RGD1566134
Stereotopy head waving duration, day 7 17.8 1 0 0 0.00 1.00 RGD1566134
Locomotion velocity, session 8 15.7 1 0 0 0.00 1.00 Syt5
Locomotion distance, session 8 9.2 1 0 0 0.00 1.00 Syt5
Degree of sensitization stereotypy 16.1 1 0 0 0.00 1.00 RGD1566134
Condit. Reinf. active minus inactive responses 11.4 1 0 0 0.00 1.00 RGD1566134
Condit. Reinf. active responses 13.2 1 0 0 0.00 1.00 RGD1566134
Condit. Reinf. inactive responses 8.3 1 0 0 0.00 1.00 RGD1566134
Incentive salience index mean 10.5 1 0 0 0.00 1.00 RGD1566134
Condit. Reinf. lever presses 5.8 1 0 0 0.00 1.00 RGD1566134
Time in familiar zone, hab. session 1 12.6 2 0 0 0.00 1.00 Snx16 Syt5
Total zone transitions, hab. session 1 25.5 1 1 25 0.00 1.00 Syt5
Total locomotion distance, hab. session 1 19.3 1 1 25 0.00 1.00 Syt5
Locomotion velocity, hab. session 1 12.3 1 0 0 0.00 1.00 Syt5
Time in familiar zone, hab. session 2 10.1 2 0 0 0.00 1.00 Snx16 Syt5
Total zone transitions, hab. session 2 7.9 1 0 0 0.00 1.00 Syt5
Total locomotion distance, hab. session 2 8.6 2 0 0 0.00 1.00 Syt5 RGD1566134
Locomotion velocity, hab. session 2 10.6 2 0 0 0.00 1.00 Syt5 RGD1566134
Novel to familiar place preference ratio 9.3 1 0 0 0.00 1.00 Ndrg3
Novelty place preference 10.1 1 0 0 0.00 1.00 Ndrg3
Time in novel zone, NPP test 10.3 1 0 0 0.00 1.00 Ndrg3
Total locomotion distance, NPP test 5.3 1 0 0 0.00 1.00 Ndrg3
Locomotion velocity, NPP test 6.5 1 0 0 0.00 1.00 Ndrg3
Pavlov. Cond. lever latency 5.5 1 0 0 0.00 1.00 RGD1566134
Pavlov. Cond. magazine entry latency 10.4 1 0 0 0.00 1.00 Syt5
Pavlov. Cond. intertrial magazine entries 13.0 2 0 0 0.00 1.00 Syt5 RGD1566134
Pavlov. Cond. response bias 13.4 1 0 0 0.00 1.00 Syt5
Bone: apparent density 11.6 1 0 0 0.00 1.00 RGD1566134
Bone surface 14.6 1 0 0 0.00 1.00 RGD1566134
Bone volume 11.6 1 0 0 0.00 1.00 RGD1566134
Bone: cortical apparent density 5.4 1 0 0 0.00 1.00 RGD1566134
Bone: cortical porosity 7.7 1 0 0 0.00 1.00 Syt5
Bone: cortical tissue density 5.2 1 0 0 0.00 1.00 RGD1566134
Bone: elastic displacement 7.7 1 0 0 0.00 1.00 Syt5
Bone: elastic work 5.8 1 0 0 0.00 1.00 Syt5
Bone: endosteal estimation 4.1 2 0 0 0.00 1.00 Snx16 RGD1566134
Bone: endosteal perimeter 7.0 1 0 0 0.00 1.00 RGD1566134
Bone: marrow area 4.2 2 0 0 0.00 1.00 Snx16 RGD1566134
Bone: maximum diameter 7.2 1 0 0 0.00 1.00 RGD1566134
Bone: minimum diameter 7.6 1 0 0 0.00 1.00 Snx16
Bone: periosteal estimation 4.4 1 0 0 0.00 1.00 Snx16
Bone: post-yield work 11.6 1 0 0 0.00 1.00 Syt5
Bone: stiffness 4.5 1 0 0 0.00 1.00 Syt5
Bone: tissue strength 13.1 1 0 0 0.00 1.00 Syt5
Bone: trabecular thickness 10.9 1 0 0 0.00 1.00 RGD1566134
Bone: trabecular tissue density 8.2 1 0 0 0.00 1.00 Syt5
Distance traveled before self-admin 37.3 2 1 25 0.00 1.00 Snx16 Syt5
Distance traveled after self-admin 32.0 2 1 25 0.00 1.00 Snx16 Syt5
Delta time in closed arm before/after self-admin 8.6 1 0 0 0.00 1.00 Snx16
Delta time in open arm before/after self-admin 18.0 1 0 0 0.00 1.00 Syt5
Diff in mean of infusions in LGA sessions 15.1 2 0 0 0.00 1.00 Snx16 Syt5
Extinction: sum of active levers before priming 36.5 1 1 25 0.00 1.00 Syt5
Active lever presses in extinction session 6 11.2 3 0 0 0.00 1.00 Snx16 Syt5 RGD1566134
Time in closed arm after self-admin 22.3 1 0 0 0.00 1.00 Syt5
Time in open arm before self-admin 16.5 1 0 0 0.00 1.00 Ndrg3
Time in open arm after self-admin 17.1 1 0 0 0.00 1.00 Syt5
Sum of active levers in priming session hrs 5-6 17.2 1 0 0 0.00 1.00 Syt5
Time to tail flick, vehicle, before self-admin 9.9 1 0 0 0.00 1.00 Snx16
Time to tail flick, test, before self-admin 38.9 2 1 25 0.00 1.00 Snx16 Syt5
Delta time to tail flick, vehicle, before/after SA 8.6 1 0 0 0.00 1.00 Syt5
Delta time to tail flick, test, before/after SA 42.4 1 1 25 0.00 1.00 Syt5
Ambulatory time before self-admin 36.6 1 1 25 0.00 1.00 Syt5
Ambulatory time after self-admin 61.3 1 1 25 0.00 1.00 Syt5
Total heroin consumption 5.8 1 0 0 0.00 1.00 Syt5
Delay disc. indifference point, 0s delay 18.1 2 1 25 0.00 1.00 Syt5 RGD1566134
Delay disc. indifference point, 16s delay 24.1 1 0 0 0.00 1.00 Syt5
Delay disc. indifference point, 24s delay 9.6 1 0 0 0.00 1.00 Syt5
Delay disc. indifference point, 4s delay 23.4 1 0 0 0.00 1.00 RGD1566134
Delay disc. indifference point, 8s delay 8.4 2 0 0 0.00 1.00 Snx16 Ndrg3
Fecal boli incidents, locomotor time 1 7.5 1 0 0 0.00 1.00 Snx16
Time >=10cm from walls, locomotor time 1 13.9 1 0 0 0.00 1.00 Snx16
Bouts of movement, locomotor time 1 33.7 2 1 25 0.00 1.00 Snx16 Syt5
Total resting periods, locomotor time 1 37.3 1 1 25 0.00 1.00 Syt5
Vertical activity count, locomotor time 1 24.2 1 0 0 0.00 1.00 Syt5
Time >=10cm from walls, locomotor time 2 14.7 1 0 0 0.00 1.00 RGD1566134
Rest time, locomotor task time 2 9.1 1 0 0 0.00 1.00 Syt5
Weight adjusted by age 23.5 4 2 50 0.23 0.77 Snx16 Syt5 Ndrg3 RGD1566134
Locomotion in novel chamber 10.6 2 0 0 0.00 1.00 Syt5 Ndrg3
Progressive ratio 10.2 2 0 0 0.00 1.00 Syt5 Ndrg3
Food seeking constrained by brief footshock 75.1 2 1 25 0.00 1.00 Snx16 Syt5
Seeking ratio, punishment vs. effort 13.5 2 0 0 0.00 1.00 Syt5 Ndrg3
Run reversals in cocaine runway, females 9.7 2 0 0 0.00 1.00 Syt5 RGD1566134
Cd content in liver 7.7 1 0 0 0.00 1.00 Syt5
Co content in liver 19.4 1 0 0 0.00 1.00 Syt5
Fe content in liver 8.8 1 0 0 0.00 1.00 RGD1566134
Na content in liver 15.7 1 0 0 0.00 1.00 RGD1566134
Rb content in liver 5.9 2 0 0 0.00 1.00 Syt5 RGD1566134
Sr content in liver 66.7 1 1 25 0.00 1.00 Syt5
Zn content in liver 13.7 2 0 0 0.00 1.00 Syt5 RGD1566134

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.08
Adipose alternative TSS 0 0.000 1.06
Adipose gene expression 1 0.012 1.13
Adipose isoform ratio 0 0.000 1.12
Adipose intron excision ratio 0 0.000 1.19
Adipose mRNA stability 0 0.000 1.13
BLA alternative polyA 0 0.000 1.06
BLA alternative TSS 0 0.000 1.09
BLA gene expression 0 0.000 1.16
BLA isoform ratio 0 0.000 1.22
BLA intron excision ratio 0 0.000 1.06
BLA mRNA stability 1 0.049 1.16
Brain alternative polyA 0 0.000 1.05
Brain alternative TSS 0 0.000 1.14
Brain gene expression 0 0.000 1.18
Brain isoform ratio 0 0.000 1.18
Brain intron excision ratio 0 0.000 1.12
Brain mRNA stability 0 0.000 1.11
Eye alternative polyA 0 0.000 0.88
Eye alternative TSS 0 0.000 1.17
Eye gene expression 0 0.000 1.07
Eye isoform ratio 0 0.000 1.23
Eye intron excision ratio 0 0.000 1.26
Eye mRNA stability 0 0.000 1.57
IL alternative polyA 0 0.000 1.14
IL alternative TSS 0 0.000 1.33
IL gene expression 0 0.000 1.15
IL isoform ratio 0 0.000 1.18
IL intron excision ratio 0 0.000 1.08
IL mRNA stability 0 0.000 1.19
LHb alternative polyA 0 0.000 1.01
LHb alternative TSS 0 0.000 1.40
LHb gene expression 0 0.000 1.22
LHb isoform ratio 0 0.000 1.15
LHb intron excision ratio 0 0.000 1.14
LHb mRNA stability 0 0.000 1.21
Liver alternative polyA 0 0.000 1.10
Liver alternative TSS 0 0.000 1.18
Liver gene expression 0 0.000 1.12
Liver isoform ratio 0 0.000 1.15
Liver intron excision ratio 1 0.023 1.15
Liver mRNA stability 0 0.000 1.12
NAcc alternative polyA 0 0.000 1.10
NAcc alternative TSS 0 0.000 1.28
NAcc gene expression 0 0.000 1.21
NAcc isoform ratio 0 0.000 1.19
NAcc intron excision ratio 0 0.000 1.13
NAcc mRNA stability 0 0.000 1.19
OFC alternative polyA 0 0.000 0.99
OFC alternative TSS 0 0.000 1.32
OFC gene expression 0 0.000 1.15
OFC isoform ratio 0 0.000 1.19
OFC intron excision ratio 0 0.000 1.05
OFC mRNA stability 0 0.000 1.15
PL alternative polyA 0 0.000 1.03
PL alternative TSS 0 0.000 1.25
PL gene expression 0 0.000 1.16
PL isoform ratio 0 0.000 1.19
PL intron excision ratio 1 0.028 1.14
PL mRNA stability 0 0.000 1.17

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.