| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000059622 | 0.0730 | 0.0410 | 2.2e-09 | 0.071 | 0.070 | 0.082 | 0.072 | 2.7e-08 | 3.0e-08 | 2.2e-09 | 1.8e-08 |
| 2 | Adipose | mRNA stability | ENSRNOG00000059622 | 0.1210 | 0.0600 | 1.5e-12 | 0.105 | 0.096 | 0.093 | 0.101 | 1.1e-11 | 8.0e-11 | 1.8e-10 | 3.0e-11 |
| 3 | Brain | gene expression | ENSRNOG00000059622 | 0.0870 | 0.0430 | 2.3e-08 | 0.097 | 0.099 | 0.101 | 0.106 | 2.9e-09 | 1.8e-09 | 1.2e-09 | 5.0e-10 |
| 4 | Brain | mRNA stability | ENSRNOG00000059622 | 0.0474 | 0.0287 | 1.8e-04 | 0.047 | 0.040 | 0.040 | 0.041 | 3.4e-05 | 1.2e-04 | 1.2e-04 | 1.0e-04 |
| 5 | Liver | gene expression | ENSRNOG00000059622 | 0.0280 | 0.0190 | 1.5e-03 | 0.023 | 0.021 | 0.023 | 0.023 | 1.2e-03 | 1.7e-03 | 1.2e-03 | 1.3e-03 |
| 6 | NAcc | gene expression | ENSRNOG00000059622 | 0.1100 | 0.0770 | 3.0e-06 | 0.077 | 0.077 | 0.073 | 0.079 | 2.2e-06 | 2.2e-06 | 4.2e-06 | 1.7e-06 |
| 7 | NAcc | mRNA stability | ENSRNOG00000059622 | 0.0481 | 0.0348 | 2.4e-03 | 0.023 | 0.025 | 0.011 | 0.018 | 7.8e-03 | 5.4e-03 | 4.8e-02 | 1.7e-02 |
| 8 | PL | gene expression | ENSRNOG00000059622 | 0.0350 | 0.0241 | 6.4e-03 | 0.023 | 0.019 | 0.016 | 0.014 | 7.2e-03 | 1.3e-02 | 2.2e-02 | 2.8e-02 |
| 9 | PL | mRNA stability | ENSRNOG00000059622 | 0.0544 | 0.0406 | 2.3e-03 | 0.042 | 0.029 | 0.025 | 0.031 | 3.5e-04 | 2.7e-03 | 4.6e-03 | 1.9e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Soleus weight | 16.1 | 46.9 | 54.8 | -6.8 | 6.1 | -7.0 | 6.3 | -6.5 | -7.4 | 6.8 | -7.1 | 7.4 |
| Tibialis anterior weight | 14.0 | 48.2 | 52.4 | -6.7 | 6.6 | -7.0 | 7.0 | -7.2 | -7.2 | 7.0 | -6.8 | 6.8 |
| Bone: trabecular tissue density | 8.6 | 12.1 | 17.9 | -3.4 | 4.1 | -3.4 | 4.2 | -3.5 | -3.1 | 3.5 | -2.8 | 2.8 |
| Extensor digitorum longus weight | 7.4 | 29.8 | 35.4 | -5.4 | 4.7 | -5.6 | 5.1 | -5.1 | -5.9 | 5.5 | -5.8 | 5.8 |
| BMI with tail | 7.1 | 23.0 | 29.2 | -5.4 | 4.2 | -4.8 | 4.5 | -4.4 | -5.0 | 4.9 | -5.0 | 4.9 |
| Weight adjusted by age | 5.9 | 6.6 | 7.3 | -2.6 | 2.6 | -2.4 | 2.6 | -2.7 | -2.6 | 2.5 | -2.5 | 2.7 |
| Cocaine response after cond. corrected | 5.7 | 6.4 | 9.0 | -2.5 | 2.8 | -2.5 | 3.0 | -2.6 | -2.4 | 2.6 | -2.1 | 2.2 |
| Locomotor activity | 5.0 | 8.0 | 10.1 | -3.1 | 3.1 | -2.8 | 3.2 | -2.6 | -2.5 | 2.9 | -2.6 | 2.5 |
| Pavlov. Cond. magazine entry latency | 4.7 | 5.4 | 7.0 | 2.3 | -1.6 | 2.4 | -2.1 | 2.6 | 2.6 | -2.3 | 2.4 | -2.4 |
| Bone: endosteal perimeter | 4.2 | 8.6 | 10.9 | -3.1 | 3.3 | -2.9 | 3.0 | -2.7 | -2.8 | 3.0 | -2.8 | 2.7 |
| Cocaine response after cond. not corrected | 4.1 | 4.5 | 7.0 | -2.1 | 2.4 | -2.1 | 2.6 | -2.3 | -1.9 | 2.2 | -1.6 | 1.7 |
| Median of all reaction times | 3.8 | 5.2 | 7.4 | 2.4 | -2.0 | 2.4 | -2.0 | 1.6 | 2.3 | -2.3 | 2.7 | -2.6 |
| Pavlov. Cond. magazine entry number | 3.7 | 4.6 | 5.4 | -2.3 | 1.4 | -2.2 | 2.1 | -2.3 | -2.3 | 2.2 | -2.1 | 2.2 |
| Body weight | 3.6 | 15.2 | 19.4 | -4.4 | 3.8 | -3.9 | 3.9 | -3.6 | -3.8 | 4.0 | -4.0 | 3.7 |
| Bone: maximum diameter | 3.4 | 6.3 | 9.3 | -2.7 | 3.0 | -2.3 | 3.0 | -2.5 | -2.1 | 2.7 | -2.0 | 1.9 |
| Delay discounting water rate 12 sec | 3.2 | 4.9 | 6.8 | -2.3 | 2.4 | -2.3 | 2.6 | -1.4 | -1.9 | 2.4 | -2.4 | 1.9 |
| Bone: periosteal perimeter | 3.2 | 5.2 | 6.9 | -2.5 | 2.6 | -2.2 | 2.5 | -2.2 | -2.1 | 2.3 | -2.0 | 2.1 |
| Locomotor testing distance | 3.1 | 5.2 | 7.6 | -2.5 | 2.6 | -2.3 | 2.7 | -2.0 | -2.0 | 2.4 | -2.0 | 2.0 |
| Reaction time mean | 3.1 | 4.3 | 6.3 | 2.2 | -1.8 | 2.2 | -1.8 | 1.4 | 2.0 | -2.1 | 2.5 | -2.3 |
| Reaction time mean AUC | 3.1 | 4.2 | 6.0 | 2.3 | -1.9 | 2.2 | -1.9 | 1.3 | 1.9 | -2.1 | 2.5 | -2.2 |
| Bone: marrow area | 3.1 | 6.6 | 8.8 | -2.6 | 2.6 | -2.5 | 2.5 | -3.0 | -2.7 | 2.6 | -2.4 | 2.3 |
| Delta distance traveled before/after self-admin | 3.0 | 3.3 | 4.3 | -1.9 | 1.9 | -2.1 | 2.0 | -1.6 | -1.7 | 1.9 | -1.6 | 1.4 |
| Latency to leave start box in cocaine runway, M | 3.0 | 2.9 | 4.8 | -1.8 | 2.2 | -1.5 | 2.2 | -1.3 | -1.5 | 1.7 | -1.5 | 1.6 |
| Bone: endosteal estimation | 2.9 | 6.2 | 8.2 | -2.5 | 2.5 | -2.4 | 2.4 | -2.9 | -2.7 | 2.5 | -2.4 | 2.2 |
| Seeking ratio, punishment vs. effort | 2.9 | 3.5 | 5.6 | -1.4 | 2.2 | -1.9 | 2.4 | -1.1 | -1.6 | 1.9 | -2.1 | 1.9 |
| Mg content in liver | 2.8 | 2.9 | 3.6 | -1.8 | 1.6 | -1.9 | 1.6 | -1.4 | -1.7 | 1.7 | -1.9 | 1.7 |
| Post-drug Anxiety | 2.7 | 2.9 | 5.9 | 1.9 | -2.4 | 1.6 | -2.4 | 1.6 | 1.3 | -1.8 | 1.1 | -0.9 |
| Pavlov. Cond. magazine entry number | 2.7 | 3.4 | 5.7 | -1.4 | 2.2 | -1.8 | 2.4 | -2.0 | -1.5 | 2.0 | -1.4 | 1.4 |
| Bone: periosteal estimation | 2.7 | 5.6 | 7.1 | -2.5 | 2.7 | -2.2 | 2.7 | -2.6 | -2.2 | 2.5 | -1.9 | 1.8 |
| Locomotion distance, session 3 | 2.6 | 2.8 | 3.7 | 1.9 | -1.7 | 1.7 | -1.8 | 1.9 | 1.5 | -1.7 | 1.4 | -1.4 |
| BMI without tail | 2.5 | 5.3 | 9.6 | -2.3 | 1.4 | -2.4 | 1.6 | -1.5 | -2.6 | 2.2 | -2.9 | 3.1 |
| Pavlov. Cond. magazine entry latency | 2.5 | 3.3 | 5.7 | 1.2 | -2.4 | 1.8 | -2.4 | 2.0 | 1.5 | -1.9 | 1.3 | -1.3 |
| Distance traveled after self-admin | 2.5 | 2.8 | 4.2 | -1.6 | 2.0 | -1.6 | 1.9 | -2.1 | -1.7 | 1.6 | -1.1 | 1.1 |
| Left kidney weight | 2.4 | 6.8 | 9.3 | -2.8 | 3.1 | -2.8 | 2.9 | -2.0 | -2.2 | 2.7 | -2.5 | 2.2 |
| Number of licking bursts | 2.4 | 2.9 | 3.4 | 1.8 | -1.8 | 1.8 | -1.7 | 1.6 | 1.6 | -1.7 | 1.7 | -1.5 |
| Condit. Reinf. active minus inactive responses | 2.3 | 2.8 | 3.5 | -1.8 | 1.9 | -1.8 | 1.6 | -1.4 | -1.6 | 1.6 | -1.8 | 1.6 |
| Liver weight, right | 2.2 | 3.6 | 5.9 | -1.8 | 1.0 | -2.0 | 1.3 | -2.0 | -2.1 | 1.8 | -2.1 | 2.4 |
| Mean num. licks in bursts | 2.2 | 2.6 | 3.8 | -2.0 | 1.7 | -1.7 | 1.9 | -1.6 | -1.3 | 1.8 | -1.4 | 1.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.2 | 2.8 | 4.1 | 1.6 | -1.1 | 1.7 | -1.6 | 2.0 | 1.9 | -1.7 | 1.6 | -1.8 |
| Change in fecal boli incidents, locomotor task | 2.2 | 2.1 | 3.7 | -1.3 | 1.4 | -1.4 | 1.8 | -1.9 | -1.4 | 1.6 | -0.9 | 0.9 |
| Length without tail | 2.1 | 4.5 | 8.2 | -2.5 | 2.9 | -2.0 | 2.8 | -2.4 | -1.3 | 2.1 | -1.4 | 0.8 |
| Delay discounting water rate 0 sec | 2.1 | 3.3 | 4.2 | -2.0 | 1.8 | -1.8 | 2.0 | -1.5 | -1.8 | 2.0 | -1.7 | 1.6 |
| Reaction time premature initiations | 2.1 | 3.0 | 4.4 | -2.0 | 1.5 | -1.9 | 1.4 | -1.3 | -1.7 | 1.7 | -2.1 | 1.9 |
| Condit. Reinf. active-inactive response ratio | 2.1 | 2.2 | 3.4 | -1.6 | 1.9 | -1.5 | 1.7 | -1.4 | -1.3 | 1.5 | -1.2 | 1.0 |
| Pavlov. Cond. index score | 2.1 | 2.6 | 5.4 | 1.3 | -2.2 | 1.6 | -2.3 | 1.8 | 1.2 | -1.8 | 1.0 | -1.0 |
| Light reinforcement 1 | 2.0 | 3.7 | 5.3 | -2.3 | 1.7 | -2.0 | 1.8 | -1.5 | -2.0 | 2.0 | -2.1 | 1.8 |
| Delta ambulatory time before/after self-admin | 2.0 | 2.2 | 3.3 | -1.5 | 1.8 | -1.6 | 1.8 | -1.3 | -1.3 | 1.6 | -1.1 | 0.9 |
| Latency to leave start box in cocaine runway | 2.0 | 2.1 | 3.6 | -1.3 | 1.5 | -1.2 | 1.4 | -1.4 | -1.7 | 1.3 | -1.2 | 1.9 |
| Reaction time number correct | 1.9 | 2.8 | 3.8 | -1.6 | 1.7 | -1.8 | 1.5 | -1.1 | -1.6 | 1.6 | -2.0 | 1.9 |
| Reaction time trials correct on left | 1.9 | 2.8 | 3.8 | -1.6 | 1.7 | -1.8 | 1.5 | -1.1 | -1.6 | 1.6 | -2.0 | 1.9 |
| Reaction time trials on left | 1.9 | 2.7 | 3.8 | -1.6 | 1.7 | -1.7 | 1.5 | -1.0 | -1.6 | 1.6 | -1.9 | 1.9 |
| Std. dev. reaction times | 1.9 | 2.7 | 3.5 | 1.9 | -1.5 | 1.7 | -1.4 | 1.4 | 1.6 | -1.7 | 1.8 | -1.8 |
| Reaction time trials completed | 1.9 | 2.7 | 3.8 | -1.6 | 1.7 | -1.7 | 1.5 | -1.0 | -1.6 | 1.6 | -1.9 | 1.9 |
| Time in novel zone, NPP test | 1.9 | 2.0 | 2.8 | -1.6 | 1.4 | -1.3 | 1.4 | -1.7 | -1.4 | 1.4 | -1.2 | 1.2 |
| Ambulatory time after self-admin | 1.9 | 2.0 | 4.3 | -1.2 | 1.8 | -1.3 | 1.8 | -2.1 | -1.4 | 1.3 | -0.7 | 0.6 |
| Rb content in liver | 1.9 | 2.4 | 3.8 | -1.3 | 1.4 | -1.7 | 1.3 | -1.2 | -1.7 | 1.5 | -1.9 | 1.7 |
| Pavlov. Cond. index score | 1.8 | 2.3 | 3.5 | 1.4 | -1.0 | 1.5 | -1.5 | 1.9 | 1.8 | -1.5 | 1.4 | -1.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.8 | 2.2 | 4.7 | 1.1 | -2.0 | 1.4 | -2.2 | 1.6 | 1.0 | -1.6 | 0.9 | -0.8 |
| Seeking ratio, delayed vs. immediate footshock | 1.8 | 2.0 | 4.1 | -1.0 | 1.2 | -1.2 | 1.0 | -1.9 | -2.0 | 1.3 | -1.4 | 1.5 |
| Indifference point function ln k | 1.7 | 2.4 | 3.9 | -1.5 | 1.9 | -1.5 | 2.0 | -1.8 | -1.3 | 1.7 | -0.8 | 1.1 |
| Indifference point function log k | 1.7 | 2.4 | 3.9 | -1.5 | 1.9 | -1.5 | 2.0 | -1.8 | -1.3 | 1.7 | -0.8 | 1.1 |
| Reaction time trials AUC | 1.7 | 2.4 | 3.5 | -1.5 | 1.7 | -1.7 | 1.4 | -1.0 | -1.5 | 1.5 | -1.9 | 1.8 |
| Pavlov. Cond. response bias | 1.7 | 2.3 | 3.0 | 1.3 | -1.3 | 1.5 | -1.7 | 1.7 | 1.6 | -1.6 | 1.4 | -1.4 |
| Incentive Sensitization - Responses | 1.7 | 1.7 | 2.7 | -1.1 | 1.5 | -1.0 | 1.6 | -1.2 | -1.5 | 1.4 | -1.2 | 1.2 |
| Time in open arm before self-admin | 1.7 | 1.8 | 2.5 | -1.6 | 1.5 | -1.4 | 1.4 | -1.5 | -1.2 | 1.4 | -1.0 | 0.9 |
| Stereotopy head waving duration, day 3 | 1.6 | 1.9 | 3.2 | -1.5 | 1.5 | -1.4 | 1.8 | -1.8 | -0.9 | 1.4 | -1.1 | 0.8 |
| Pavlov. Cond. latency score | 1.6 | 2.1 | 4.5 | 1.1 | -2.0 | 1.3 | -2.1 | 1.8 | 1.0 | -1.5 | 0.7 | -0.8 |
| Bone: stiffness | 1.6 | 2.5 | 3.0 | -1.3 | 1.6 | -1.7 | 1.7 | -1.6 | -1.7 | 1.6 | -1.6 | 1.5 |
| Novelty place preference | 1.5 | 1.5 | 2.1 | -1.5 | 1.1 | -1.2 | 1.1 | -1.4 | -1.3 | 1.2 | -1.2 | 1.1 |
| Time to tail flick, test, after self-admin | 1.5 | 1.5 | 2.3 | 1.5 | -1.1 | 1.1 | -1.0 | 1.3 | 1.3 | -1.2 | 1.3 | -1.1 |
| Incentive Sensitization - Breakpoint | 1.4 | 1.4 | 2.2 | -1.0 | 1.4 | -0.9 | 1.5 | -0.9 | -1.3 | 1.2 | -1.1 | 1.1 |
| Pavlov. Cond. response bias | 1.4 | 1.7 | 3.6 | 0.9 | -1.7 | 1.3 | -1.9 | 1.4 | 0.9 | -1.4 | 0.9 | -0.9 |
| Bone: connectivity density | 1.4 | 2.2 | 3.3 | 1.7 | -1.3 | 1.4 | -1.6 | 1.8 | 1.4 | -1.6 | 1.1 | -1.2 |
| Bone: cortical porosity | 1.4 | 1.5 | 2.1 | 1.0 | -1.2 | 1.4 | -1.0 | 0.8 | 1.3 | -1.3 | 1.4 | -1.4 |
| Delta time in open arm before/after self-admin | 1.4 | 1.4 | 2.6 | 1.6 | -0.8 | 1.2 | -0.9 | 0.9 | 1.3 | -1.3 | 1.1 | -1.1 |
| Na content in liver | 1.4 | 1.4 | 1.9 | -1.3 | 0.7 | -1.3 | 1.1 | -1.0 | -1.3 | 1.3 | -1.3 | 1.4 |
| Condit. Reinf. active responses | 1.3 | 1.8 | 2.5 | -1.6 | 1.4 | -1.5 | 1.1 | -0.9 | -1.1 | 1.3 | -1.5 | 1.4 |
| Pavlov. Cond. latency score | 1.3 | 1.7 | 2.5 | 1.2 | -0.6 | 1.3 | -1.2 | 1.6 | 1.5 | -1.2 | 1.3 | -1.5 |
| Right kidney weight | 1.2 | 3.6 | 4.8 | -2.2 | 1.7 | -2.1 | 1.9 | -1.5 | -1.7 | 1.9 | -2.1 | 1.7 |
| Indifference point AUC | 1.2 | 1.4 | 3.2 | 1.0 | -1.7 | 1.0 | -1.8 | 1.2 | 0.7 | -1.2 | 0.4 | -0.5 |
| Intermittent access day 1 locomotion | 1.2 | 1.2 | 2.5 | 1.3 | -0.9 | 1.3 | -0.6 | 0.3 | 0.9 | -1.1 | 1.6 | -1.4 |
| Locomotion distance, session 7 | 1.2 | 1.5 | 2.1 | 1.4 | -1.2 | 1.2 | -1.5 | 1.4 | 1.0 | -1.3 | 0.9 | -1.1 |
| Novel to familiar place preference ratio | 1.2 | 1.3 | 1.8 | -1.3 | 1.0 | -1.1 | 1.0 | -1.3 | -1.2 | 1.1 | -1.1 | 1.1 |
| Bone: maximum force | 1.2 | 2.1 | 2.7 | -1.5 | 1.6 | -1.4 | 1.6 | -1.5 | -1.3 | 1.4 | -1.2 | 1.1 |
| Food consumed during 24 hour testing period | 1.1 | 1.3 | 3.0 | -1.1 | 1.3 | -1.0 | 1.4 | -1.7 | -0.9 | 1.2 | -0.6 | 0.5 |
| Reaction time mean minus median AUC | 1.1 | 1.4 | 2.5 | 1.3 | -1.0 | 1.1 | -1.0 | 1.0 | 1.3 | -1.2 | 1.3 | -1.6 |
| Locomotion velocity, session 1 | 1.1 | 1.2 | 1.7 | -1.1 | 0.8 | -1.3 | 1.1 | -0.8 | -1.0 | 1.2 | -1.3 | 1.1 |
| Bone: final force | 1.1 | 1.9 | 2.9 | -1.5 | 1.7 | -1.3 | 1.5 | -1.5 | -1.2 | 1.4 | -1.0 | 1.0 |
| Bone: tissue strength | 1.1 | 1.1 | 2.0 | 1.1 | -0.8 | 1.1 | -0.8 | 0.6 | 1.1 | -1.0 | 1.2 | -1.4 |
| Liver weight, left | 1.0 | 1.6 | 2.0 | -1.3 | 0.9 | -1.3 | 1.1 | -1.3 | -1.3 | 1.3 | -1.3 | 1.4 |
| Mean time between licks in bursts | 1.0 | 1.4 | 1.9 | 1.4 | -1.0 | 1.3 | -1.0 | 0.9 | 1.2 | -1.2 | 1.4 | -1.1 |
| Cocaine response before conditioning | 1.0 | 1.3 | 1.7 | 0.9 | -1.3 | 1.1 | -1.3 | 1.0 | 1.2 | -1.1 | 1.0 | -1.0 |
| Pavlov. Cond. change in total contacts | 1.0 | 1.4 | 2.5 | 1.1 | -0.9 | 1.1 | -1.2 | 1.6 | 1.3 | -1.2 | 1.0 | -1.1 |
| Baseline Anxiety | 1.0 | 1.1 | 2.0 | 1.4 | -1.0 | 0.9 | -1.1 | 1.2 | 0.9 | -1.1 | 0.8 | -0.6 |
| Stereotopy head waving duration, day 7 | 1.0 | 1.3 | 1.8 | -0.9 | 0.8 | -1.3 | 1.1 | -1.0 | -1.1 | 1.1 | -1.4 | 1.2 |
| Bone: maximum moment | 1.0 | 1.7 | 2.5 | -1.4 | 1.6 | -1.3 | 1.6 | -1.4 | -1.1 | 1.3 | -0.9 | 0.8 |
| Total heroin consumption | 1.0 | 1.2 | 2.4 | -1.1 | 0.6 | -1.2 | 0.5 | -1.1 | -1.2 | 1.0 | -1.3 | 1.5 |
| Condit. Reinf. lever reinforcers received | 0.9 | 1.2 | 2.0 | -1.4 | 1.3 | -1.2 | 0.9 | -0.7 | -0.8 | 1.1 | -1.2 | 1.1 |
| Short access total infusions | 0.9 | 1.0 | 2.0 | 1.3 | -0.9 | 1.1 | -0.4 | 0.1 | 0.7 | -0.9 | 1.4 | -1.3 |
| Stereotopy head waving bouts, day 7 | 0.9 | 1.0 | 1.6 | -1.0 | 0.8 | -1.2 | 1.0 | -0.7 | -0.9 | 1.0 | -1.3 | 0.9 |
| Degree of sensitization stereotypy | 0.9 | 0.9 | 1.7 | -1.0 | 0.8 | -1.2 | 0.9 | -0.5 | -0.9 | 1.0 | -1.3 | 1.0 |
| Bone: final moment | 0.9 | 1.5 | 2.5 | -1.4 | 1.6 | -1.1 | 1.5 | -1.4 | -1.0 | 1.2 | -0.7 | 0.7 |
| Diff in mean of infusions in LGA sessions | 0.9 | 1.0 | 2.5 | -1.1 | -0.0 | -0.9 | -0.1 | -1.6 | -1.3 | 0.8 | -1.0 | 1.2 |
| Delay disc. indifference point, 0s delay | 0.9 | 1.0 | 2.0 | 0.9 | -1.2 | 1.0 | -1.2 | 1.4 | 0.8 | -1.0 | 0.7 | -0.5 |
| Time >=10cm from walls, locomotor time 1 | 0.9 | 0.9 | 1.4 | -1.2 | 0.8 | -0.9 | 0.6 | -1.0 | -1.0 | 1.0 | -0.9 | 1.1 |
| Fe content in liver | 0.9 | 1.1 | 1.7 | 1.3 | -1.2 | 0.8 | -1.2 | 1.3 | 0.9 | -1.0 | 0.6 | -0.7 |
| K content in liver | 0.9 | 0.9 | 1.5 | -1.0 | 0.8 | -1.2 | 1.0 | -0.5 | -0.7 | 0.9 | -1.2 | 0.8 |
| Reaction time false alarm rate | 0.8 | 1.2 | 1.7 | 1.2 | -1.1 | 1.0 | -0.9 | 0.9 | 1.3 | -1.1 | 1.1 | -1.1 |
| Pavlov. Cond. intertrial magazine entries | 0.8 | 1.1 | 1.3 | -1.0 | 0.8 | -1.1 | 1.1 | -1.2 | -0.9 | 1.0 | -1.1 | 0.9 |
| Intermitt. access escalation Index | 0.8 | 0.7 | 1.6 | -0.9 | 1.3 | -0.6 | 1.2 | -0.3 | -0.9 | 0.7 | -0.6 | 0.8 |
| Progressive ratio test 2 breakpoint | 0.8 | 0.9 | 2.1 | -0.5 | 1.2 | -0.6 | 1.4 | -1.0 | -1.0 | 0.9 | -0.7 | 0.7 |
| Stereotopy head waving bouts, day 3 | 0.8 | 1.0 | 2.3 | -1.0 | 1.0 | -0.9 | 1.3 | -1.5 | -0.6 | 1.0 | -0.7 | 0.4 |
| Locomotion velocity, session 7 | 0.8 | 0.9 | 1.2 | 1.1 | -0.9 | 1.0 | -1.0 | 0.8 | 0.8 | -1.0 | 0.9 | -0.9 |
| Bone: cortical area | 0.8 | 1.2 | 2.9 | -1.3 | 1.7 | -0.8 | 1.7 | -1.1 | -0.4 | 1.1 | -0.3 | 0.3 |
| Bone: trabecular number | 0.8 | 1.2 | 1.8 | 1.3 | -1.0 | 1.0 | -1.2 | 1.4 | 1.1 | -1.2 | 0.9 | -1.1 |
| Time to tail flick, vehicle, after self-admin | 0.8 | 0.8 | 2.9 | -0.8 | 0.9 | -0.6 | 0.9 | -1.7 | -0.9 | 0.8 | -0.4 | 0.5 |
| Total resting periods, locomotor time 2 | 0.8 | 0.8 | 1.5 | -0.9 | 0.7 | -1.0 | 0.7 | -0.5 | -1.0 | 0.9 | -1.2 | 1.2 |
| Vertical activity count, locomotor time 2 | 0.8 | 0.9 | 2.3 | 1.5 | -0.6 | 0.9 | -0.7 | 1.1 | 0.7 | -1.1 | 0.8 | -0.7 |
| Delay discounting time to switch 0 sec | 0.7 | 1.0 | 1.4 | 1.2 | -0.8 | 1.1 | -0.9 | 0.5 | 1.0 | -1.2 | 1.1 | -0.9 |
| Locomotor testing rearing | 0.7 | 1.2 | 1.5 | -1.0 | 1.1 | -1.2 | 1.2 | -0.7 | -1.1 | 1.1 | -1.2 | 1.2 |
| Reaction time premature initiation rate | 0.7 | 0.9 | 1.4 | -1.2 | 0.6 | -1.1 | 0.6 | -0.9 | -0.9 | 1.0 | -1.2 | 1.1 |
| Intermittent access day 15 total infusions | 0.7 | 0.8 | 1.7 | 1.3 | -0.7 | 0.9 | -0.4 | 0.4 | 0.7 | -0.8 | 1.1 | -1.1 |
| Intermittent access day 15 total locomotion | 0.7 | 0.7 | 1.9 | 1.0 | -0.1 | 1.0 | 0.0 | -0.0 | 0.8 | -0.8 | 1.4 | -1.2 |
| Short access day 1 total inactive lever presses | 0.7 | 0.8 | 1.9 | -0.6 | 1.4 | -0.8 | 1.4 | -0.8 | -0.6 | 0.9 | -0.5 | 0.6 |
| Short access day 10 total infusions | 0.7 | 0.7 | 1.7 | 1.1 | -0.6 | 1.0 | -0.3 | 0.0 | 0.6 | -0.8 | 1.2 | -1.3 |
| Extinction: sum of active levers before priming | 0.7 | 0.8 | 1.3 | 0.9 | -0.6 | 0.9 | -0.8 | 0.6 | 1.1 | -0.9 | 1.0 | -1.0 |
| Time to tail flick, vehicle, before self-admin | 0.7 | 0.7 | 2.2 | 0.7 | -1.5 | 0.6 | -1.5 | 0.7 | 0.4 | -0.7 | -0.1 | 0.1 |
| Time to tail flick, test, before self-admin | 0.7 | 0.7 | 1.1 | 0.8 | -1.0 | 0.8 | -1.0 | 1.0 | 0.7 | -0.9 | 0.7 | -0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.7 | 0.7 | 1.9 | -0.5 | 1.2 | -0.3 | 1.2 | -1.4 | -0.7 | 0.6 | 0.4 | -0.2 |
| Bouts of movement, locomotor time 2 | 0.7 | 0.8 | 1.5 | -0.7 | 0.7 | -1.0 | 0.6 | -0.4 | -1.0 | 0.9 | -1.2 | 1.2 |
| Sr content in liver | 0.7 | 0.6 | 0.9 | 0.8 | -0.9 | 0.9 | -0.9 | 0.9 | 0.6 | -0.8 | 0.7 | -0.6 |
| Delay discounting total patch changes 12 sec | 0.6 | 0.7 | 1.5 | 0.9 | -1.2 | 0.8 | -0.9 | 1.2 | 0.7 | -0.8 | 0.3 | -0.5 |
| Social response proportion | 0.6 | 0.7 | 2.1 | -0.9 | 0.8 | -0.6 | 0.7 | -1.5 | -0.8 | 0.8 | -0.5 | 0.5 |
| Pavlov. Cond. lever latency | 0.6 | 0.8 | 1.2 | -0.7 | 0.7 | -0.9 | 1.0 | -1.0 | -1.1 | 0.9 | -0.8 | 1.0 |
| Lifetime Intake | 0.6 | 0.7 | 1.4 | 1.2 | -0.5 | 0.9 | -0.1 | 0.0 | 0.6 | -0.7 | 1.2 | -1.1 |
| Progressive ratio test 2 active lever presses | 0.6 | 0.6 | 1.4 | -0.3 | 0.9 | -0.5 | 1.2 | -1.0 | -1.0 | 0.8 | -0.6 | 0.5 |
| Short access total locomotion | 0.6 | 0.6 | 1.7 | 0.9 | -0.4 | 0.9 | -0.2 | -0.1 | 0.7 | -0.7 | 1.3 | -0.9 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.7 | 1.7 | 0.6 | -1.1 | 0.9 | -1.3 | 0.8 | 0.4 | -0.9 | 0.4 | -0.4 |
| Condit. Reinf. inactive responses | 0.6 | 0.7 | 1.6 | 0.2 | -1.0 | -0.4 | -1.0 | 1.2 | -0.4 | -0.1 | -1.3 | 1.1 |
| Bone: cortical porosity | 0.6 | 0.7 | 1.2 | 0.5 | -0.7 | 0.9 | -0.5 | 0.6 | 1.0 | -0.8 | 1.0 | -1.1 |
| Bone: cortical tissue density | 0.6 | 0.7 | 0.9 | 0.8 | -0.9 | 0.8 | -0.8 | 0.9 | 1.0 | -0.8 | 0.9 | -0.9 |
| Food seeking constrained by brief footshock | 0.6 | 0.8 | 1.5 | -0.6 | 0.7 | -0.8 | 0.7 | -0.6 | -0.9 | 0.9 | -1.1 | 1.2 |
| Se content in liver | 0.6 | 0.8 | 1.8 | 1.0 | -0.1 | 0.6 | -0.7 | 1.3 | 1.1 | -0.9 | 0.7 | -0.9 |
| Glucose | 0.5 | 0.8 | 1.4 | -0.8 | 0.5 | -0.9 | 0.8 | -1.2 | -1.1 | 1.0 | -0.8 | 0.9 |
| Parametrial fat weight | 0.5 | 1.1 | 2.1 | 1.2 | -0.9 | 1.0 | -0.7 | 1.4 | 1.2 | -0.9 | 0.8 | -0.8 |
| Intermittent access day 1 total infusions | 0.5 | 0.6 | 1.6 | 0.9 | -0.4 | 0.9 | -0.0 | 0.0 | 0.6 | -0.6 | 1.3 | -1.2 |
| Intermittent access total infusions | 0.5 | 0.5 | 1.2 | 1.0 | -0.3 | 0.8 | 0.1 | -0.2 | 0.5 | -0.6 | 1.1 | -1.0 |
| Intermittent access standard deviation | 0.5 | 0.5 | 1.0 | 1.0 | -0.6 | 0.8 | -0.4 | 0.4 | 0.6 | -0.6 | 0.9 | -0.8 |
| Progressive ratio test 1 inactive lever presses | 0.5 | 0.5 | 1.4 | 1.2 | -0.6 | 0.7 | -0.4 | -0.1 | 0.5 | -0.6 | 0.9 | -0.9 |
| Progressive ratio test 2 inactive lever presses | 0.5 | 0.5 | 1.4 | 0.8 | -0.1 | 0.9 | 0.2 | 0.3 | 0.9 | -0.5 | 0.9 | -1.2 |
| Compulsive drug intake | 0.5 | 0.5 | 1.0 | -0.8 | 0.5 | -0.7 | 0.5 | -0.6 | -0.7 | 0.8 | -0.5 | 1.0 |
| Condit. Reinf. active-inactive response ratio | 0.5 | 0.6 | 1.3 | 0.5 | -0.5 | 1.0 | -0.6 | -0.2 | 0.6 | -0.7 | 1.1 | -1.0 |
| Total zone transitions, hab. session 1 | 0.5 | 0.6 | 2.7 | 0.8 | -0.8 | 0.5 | -0.7 | 1.7 | 0.7 | -0.6 | 0.1 | -0.3 |
| Bone: cortical apparent density | 0.5 | 0.7 | 0.9 | 0.7 | -0.9 | 0.8 | -0.7 | 0.9 | 1.0 | -0.8 | 0.9 | -0.8 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 1.0 | -1.0 | 0.3 | -0.7 | 0.4 | -0.3 | -0.8 | 0.7 | -0.8 | 0.9 |
| Locomotion in novel chamber | 0.5 | 0.6 | 1.5 | 0.8 | -0.5 | 0.8 | -0.3 | 0.2 | 0.8 | -0.6 | 1.2 | -1.0 |
| Heart weight | 0.4 | 0.6 | 1.1 | -1.0 | 1.1 | -0.9 | 0.8 | 0.0 | -0.5 | 0.8 | -1.0 | 0.4 |
| Delay discounting total patch changes 24 sec | 0.4 | 0.5 | 1.5 | 0.8 | -1.0 | 0.5 | -0.6 | 1.2 | 0.3 | -0.5 | -0.0 | 0.1 |
| Delay discounting water rate 18 sec | 0.4 | 0.5 | 1.1 | -0.8 | 0.8 | -0.8 | 1.0 | -0.3 | -0.4 | 0.9 | -0.7 | 0.3 |
| Light reinforcement 2 | 0.4 | 0.5 | 1.6 | 0.3 | -0.2 | 0.7 | -0.1 | -0.1 | 0.8 | -0.4 | 1.3 | -1.2 |
| Reaction time mean minus median | 0.4 | 0.6 | 0.9 | 0.9 | -0.6 | 0.7 | -0.6 | 0.5 | 0.7 | -0.7 | 0.9 | -0.9 |
| Condit. Reinf. inactive responses | 0.4 | 0.5 | 1.2 | 0.5 | -0.8 | 0.4 | -1.0 | 1.1 | 0.7 | -0.7 | 0.1 | -0.2 |
| Pavlov. Cond. lever contacts | 0.4 | 0.5 | 0.8 | 0.5 | -0.6 | 0.7 | -0.9 | 0.8 | 0.9 | -0.7 | 0.7 | -0.8 |
| Intermittent access terminal intake (last 3 days) | 0.4 | 0.4 | 1.2 | 0.8 | -0.6 | 0.8 | -0.3 | -0.0 | 0.4 | -0.6 | 1.1 | -0.8 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 1.2 | 0.6 | -0.1 | 0.6 | -0.2 | 0.5 | 1.1 | -0.6 | 0.7 | -0.8 |
| One hour access (shock baseline) | 0.4 | 0.4 | 1.2 | 0.9 | -0.4 | 0.7 | -0.1 | -0.0 | 0.5 | -0.6 | 0.8 | -1.1 |
| Condit. Reinf. active responses | 0.4 | 0.5 | 1.7 | 0.3 | -1.2 | 0.3 | -1.3 | 1.0 | -0.0 | -0.6 | -0.4 | 0.4 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 1.4 | 0.2 | -0.9 | 0.5 | -1.2 | 0.7 | 0.3 | -0.7 | 0.2 | -0.2 |
| Pavlov. Cond. lever contacts | 0.4 | 0.5 | 1.6 | 0.4 | -0.9 | 0.7 | -1.3 | 0.9 | 0.3 | -0.8 | 0.2 | -0.2 |
| Bone: cortical thickness | 0.4 | 0.6 | 1.4 | 0.3 | 0.0 | 0.7 | 0.2 | 0.6 | 1.2 | -0.4 | 1.2 | -1.2 |
| Progressive ratio | 0.4 | 0.5 | 1.6 | 0.3 | -1.1 | 0.7 | -1.3 | 0.1 | 0.3 | -0.7 | 0.6 | -0.4 |
| Latency to leave start box in cocaine runway, F | 0.4 | 0.5 | 1.6 | -0.4 | 0.4 | -0.5 | 0.4 | -0.6 | -1.1 | 0.5 | -0.6 | 1.3 |
| Cu content in liver | 0.4 | 0.5 | 0.7 | -0.8 | 0.6 | -0.8 | 0.5 | -0.6 | -0.8 | 0.6 | -0.8 | 0.9 |
| Mn content in liver | 0.4 | 0.4 | 1.0 | -1.0 | 0.7 | -0.6 | 0.9 | -0.8 | -0.2 | 0.7 | -0.1 | 0.2 |
| Delay discounting water rate 6 sec | 0.3 | 0.5 | 1.0 | -0.5 | 1.0 | -0.6 | 0.9 | -0.5 | -0.7 | 0.8 | -0.7 | 0.4 |
| Social time | 0.3 | 0.4 | 0.8 | -0.5 | 0.7 | -0.6 | 0.8 | -0.9 | -0.5 | 0.6 | -0.7 | -0.0 |
| Cocaine induced anxiety | 0.3 | 0.4 | 1.0 | 0.4 | -1.0 | 0.6 | -0.9 | 0.4 | 0.4 | -0.6 | 0.2 | -0.3 |
| Locomotion distance, session 2 | 0.3 | 0.4 | 1.2 | -0.4 | 0.1 | -0.6 | -0.1 | -0.0 | -0.7 | 0.4 | -1.1 | 0.9 |
| Locomotion velocity, session 8 | 0.3 | 0.3 | 0.8 | -0.3 | 0.1 | -0.7 | 0.2 | -0.4 | -0.7 | 0.4 | -0.9 | 0.7 |
| Locomotion distance, session 8 | 0.3 | 0.4 | 1.2 | 0.6 | -1.1 | 0.4 | -1.0 | 0.7 | 0.3 | -0.6 | -0.0 | -0.3 |
| Incentive salience index mean | 0.3 | 0.4 | 1.3 | 0.1 | -0.9 | 0.6 | -1.1 | 0.5 | 0.1 | -0.6 | 0.1 | -0.1 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 1.0 | -0.6 | 0.7 | -0.3 | 0.7 | -1.0 | -0.3 | 0.5 | -0.0 | 0.0 |
| Pavlov. Cond. lever latency | 0.3 | 0.3 | 1.1 | -0.1 | 0.9 | -0.3 | 1.0 | -0.9 | -0.1 | 0.5 | 0.3 | -0.1 |
| Bone: minimum diameter | 0.3 | 0.6 | 1.5 | -1.0 | 1.2 | -0.5 | 1.1 | -0.8 | -0.3 | 0.8 | -0.2 | 0.0 |
| Bone: trabecular thickness | 0.3 | 0.3 | 1.0 | -0.5 | 1.0 | -0.5 | 1.0 | -0.3 | -0.1 | 0.6 | -0.1 | -0.0 |
| Ambulatory time before self-admin | 0.3 | 0.3 | 0.6 | 0.7 | -0.2 | 0.7 | -0.4 | -0.2 | 0.3 | -0.6 | 0.8 | -0.5 |
| Rest time, locomotor task time 2 | 0.3 | 0.3 | 1.0 | 0.1 | -0.6 | 0.5 | -0.4 | 0.1 | 0.7 | -0.4 | 1.0 | -0.6 |
| Epididymis fat weight | 0.2 | 0.5 | 1.4 | 0.9 | -0.6 | 0.4 | -0.6 | 1.2 | 0.6 | -0.7 | -0.1 | -0.3 |
| Tail length | 0.2 | 0.8 | 1.5 | 1.0 | -1.0 | 0.7 | -1.1 | 1.2 | 0.6 | -0.9 | 0.4 | -0.2 |
| Water consumed over 24 hours | 0.2 | 0.2 | 0.7 | 0.3 | -0.5 | 0.5 | -0.2 | 0.1 | 0.5 | -0.3 | 0.7 | -0.8 |
| Delay discounting total patch changes 0 sec | 0.2 | 0.3 | 0.6 | -0.3 | 0.2 | -0.5 | 0.8 | -0.2 | -0.5 | 0.6 | -0.5 | 0.6 |
| Delay discounting total patch changes 6 sec | 0.2 | 0.3 | 0.8 | 0.2 | -0.9 | 0.1 | -0.6 | 0.9 | -0.2 | -0.2 | -0.5 | 0.8 |
| Reaction time num false alarms | 0.2 | 0.3 | 0.4 | 0.7 | -0.5 | 0.4 | -0.4 | 0.5 | 0.7 | -0.5 | 0.4 | -0.4 |
| Conditioned locomotion | 0.2 | 0.2 | 0.7 | -0.8 | 0.6 | -0.4 | 0.2 | 0.1 | -0.2 | 0.4 | -0.4 | 0.4 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.9 | 0.3 | -0.0 | 0.4 | -0.2 | 0.3 | 1.0 | -0.4 | 0.8 | -1.0 |
| Conditioned locomotion | 0.2 | 0.2 | 0.5 | 0.3 | -0.6 | 0.7 | -0.2 | -0.0 | 0.4 | -0.5 | 0.7 | -0.5 |
| Intermittent access intake day 1-15 change | 0.2 | 0.2 | 1.2 | 0.5 | -0.3 | 0.0 | -0.2 | 1.1 | 0.5 | -0.1 | -0.1 | 0.2 |
| Intermittent access intake escalation | 0.2 | 0.2 | 0.5 | 0.7 | -0.5 | 0.2 | -0.4 | 0.5 | 0.4 | -0.3 | 0.1 | -0.1 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.5 | -0.1 | 0.4 | -0.2 | 0.7 | -0.7 | -0.4 | 0.4 | -0.1 | 0.2 |
| Total sessions with >9 infusions | 0.2 | 0.2 | 0.8 | 0.2 | 0.0 | -0.2 | 0.3 | -0.9 | -0.6 | 0.3 | -0.0 | 0.3 |
| Short access day 1 total infusions | 0.2 | 0.2 | 0.6 | 0.6 | 0.0 | 0.6 | 0.2 | -0.4 | -0.0 | -0.3 | 0.8 | -0.3 |
| Short access day 1 locomotion | 0.2 | 0.2 | 0.8 | -0.0 | 0.2 | -0.1 | 0.4 | -0.9 | -0.6 | 0.2 | -0.1 | 0.3 |
| Short access day 10 total locomotion | 0.2 | 0.2 | 0.5 | -0.3 | 0.7 | -0.1 | 0.7 | -0.6 | -0.1 | 0.3 | 0.3 | 0.0 |
| Locomotion distance, session 1 | 0.2 | 0.2 | 0.7 | 0.3 | -0.8 | 0.3 | -0.6 | 0.7 | 0.4 | -0.3 | 0.2 | -0.3 |
| Condit. Reinf. lever presses | 0.2 | 0.2 | 1.1 | -0.1 | -0.7 | 0.2 | -1.1 | 0.3 | 0.0 | -0.4 | -0.2 | 0.1 |
| Total zone transitions, hab. session 2 | 0.2 | 0.2 | 0.7 | -0.1 | -0.5 | -0.1 | -0.6 | 0.8 | -0.1 | -0.1 | -0.7 | 0.4 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.3 | 0.9 | -0.6 | -0.2 | -0.5 | -0.4 | 0.6 | -0.2 | 0.2 | -0.9 | 0.7 |
| Total locomotion distance, NPP test | 0.2 | 0.3 | 1.0 | -0.6 | 0.1 | -0.6 | -0.0 | 0.4 | -0.3 | 0.4 | -1.0 | 0.7 |
| Locomotion velocity, NPP test | 0.2 | 0.2 | 0.8 | -0.1 | -0.4 | -0.2 | -0.5 | 0.9 | 0.0 | -0.1 | -0.7 | 0.4 |
| Bone surface | 0.2 | 0.4 | 0.6 | -0.5 | 0.7 | -0.5 | 0.7 | -0.5 | -0.6 | 0.6 | -0.6 | 0.5 |
| Bone volume | 0.2 | 0.4 | 0.7 | -0.6 | 0.8 | -0.6 | 0.8 | -0.4 | -0.6 | 0.6 | -0.6 | 0.5 |
| Bone: cortical thickness | 0.2 | 0.3 | 1.0 | 0.3 | -0.2 | 0.6 | -0.1 | -0.2 | 0.7 | -0.4 | 1.0 | -0.6 |
| Bone: post-yield work | 0.2 | 0.3 | 0.6 | -0.4 | 0.2 | -0.6 | 0.3 | -0.3 | -0.6 | 0.4 | -0.8 | 0.6 |
| Time in closed arm before self-admin | 0.2 | 0.2 | 0.7 | 0.3 | -0.8 | 0.4 | -0.5 | 0.3 | 0.2 | -0.4 | 0.2 | -0.2 |
| Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 0.5 | -0.4 | 0.5 | -0.4 | 0.3 | -0.7 | -0.5 | 0.4 | -0.3 | 0.3 |
| Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 0.7 | 0.1 | -0.4 | 0.2 | -0.2 | 0.8 | 0.7 | -0.3 | 0.4 | -0.3 |
| Delay disc. indifference point, 4s delay | 0.2 | 0.2 | 0.4 | 0.3 | -0.5 | 0.6 | -0.6 | 0.5 | 0.3 | -0.5 | 0.6 | -0.4 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.3 | 0.4 | 0.4 | -0.2 | 0.6 | -0.5 | 0.5 | 0.5 | -0.6 | 0.5 | -0.5 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.6 | -0.1 | -0.1 | 0.5 | -0.0 | 0.3 | 0.7 | -0.3 | 0.8 | -0.3 |
| Locomotion in novel chamber post-restriction | 0.2 | 0.2 | 0.6 | 0.3 | -0.6 | 0.4 | -0.5 | 0.8 | 0.5 | -0.4 | 0.4 | -0.2 |
| Run reversals in cocaine runway, males | 0.2 | 0.2 | 0.7 | 0.0 | -0.3 | -0.4 | -0.1 | 0.2 | -0.4 | 0.1 | -0.9 | 0.7 |
| Cd content in liver | 0.2 | 0.3 | 1.1 | 0.3 | -0.5 | 0.5 | -0.6 | 1.0 | 0.2 | -0.5 | -0.1 | -0.0 |
| Length with tail | 0.1 | 0.3 | 1.0 | -0.6 | 1.0 | -0.6 | 0.8 | -0.3 | -0.3 | 0.5 | -0.5 | 0.3 |
| Retroperitoneal fat weight | 0.1 | 0.2 | 1.2 | -0.1 | -0.1 | -0.2 | -0.2 | 1.1 | 0.5 | -0.0 | -0.4 | -0.2 |
| Intraocular pressure | 0.1 | 0.1 | 0.7 | 0.4 | 0.1 | 0.1 | 0.1 | 0.8 | 0.3 | -0.2 | 0.1 | -0.1 |
| Tibia length | 0.1 | 0.4 | 1.3 | -0.9 | 0.7 | -0.1 | 0.7 | -1.2 | -0.1 | 0.5 | 0.4 | -0.5 |
| Times rat made contact with spout | 0.1 | 0.1 | 0.4 | -0.1 | -0.2 | 0.2 | 0.1 | 0.4 | 0.6 | 0.0 | 0.4 | -0.6 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.3 | 0.1 | 0.4 | -0.1 | -0.0 | 0.1 | -0.3 | 0.0 | -0.3 | 0.6 |
| Indifference point 0 sec | 0.1 | 0.1 | 0.3 | -0.1 | -0.1 | -0.3 | 0.5 | -0.1 | -0.4 | 0.4 | -0.3 | 0.5 |
| Delay discounting total patch changes 18 sec | 0.1 | 0.1 | 0.3 | 0.3 | -0.5 | 0.3 | -0.2 | 0.5 | 0.4 | -0.2 | 0.1 | -0.2 |
| Delay discounting water rate 24 sec | 0.1 | 0.2 | 0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 0.7 | 0.4 | -0.2 | 0.2 | -0.6 |
| Social responses | 0.1 | 0.1 | 0.3 | -0.4 | 0.2 | -0.4 | 0.3 | -0.2 | -0.2 | 0.4 | -0.6 | 0.1 |
| Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.3 | -0.1 | 0.4 | -0.2 | 0.6 | 0.2 | 0.0 | 0.3 | -0.2 | 0.2 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.2 | -0.1 | 0.2 | -0.3 | 0.3 | -0.2 | -0.3 | 0.4 | -0.4 | 0.4 |
| Intermitt. access day 1 inactive lever presses | 0.1 | 0.1 | 0.5 | -0.0 | -0.2 | 0.3 | -0.0 | 0.1 | 0.7 | -0.1 | 0.7 | -0.2 |
| Intermitt. access day 15 inactive lever presses | 0.1 | 0.2 | 0.6 | -0.1 | -0.3 | 0.3 | -0.1 | 0.5 | 0.8 | -0.2 | 0.1 | -0.6 |
| Intermittent access total locomotion | 0.1 | 0.2 | 0.4 | 0.4 | 0.2 | 0.3 | 0.5 | -0.4 | 0.2 | -0.2 | 0.6 | -0.4 |
| Progressive ratio test 1 breakpoint | 0.1 | 0.1 | 0.2 | 0.1 | 0.0 | 0.1 | 0.3 | -0.5 | -0.1 | 0.1 | 0.3 | -0.1 |
| One hour access (0.3 mA shock) | 0.1 | 0.2 | 0.5 | -0.2 | 0.4 | -0.2 | 0.7 | -0.6 | -0.4 | 0.5 | -0.0 | 0.2 |
| Number of responses in last shaping day | 0.1 | 0.1 | 0.3 | -0.2 | 0.1 | -0.0 | 0.2 | -0.5 | -0.0 | 0.1 | 0.1 | 0.3 |
| Context. condit. distance diff. score | 0.1 | 0.1 | 0.3 | 0.1 | -0.5 | 0.2 | -0.1 | 0.1 | 0.4 | -0.2 | 0.4 | -0.6 |
| Locomotion velocity, session 2 | 0.1 | 0.1 | 0.3 | -0.2 | -0.2 | -0.2 | -0.2 | -0.0 | -0.2 | 0.0 | -0.5 | 0.3 |
| Locomotion velocity, session 3 | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | -0.1 | -0.2 | 0.3 | -0.1 | -0.1 | -0.5 | 0.2 |
| Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | -0.0 | -0.1 | 0.4 | 0.1 | 0.0 | -0.1 | -0.2 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.3 | 0.6 | 0.5 | 0.2 | 0.1 | -0.1 | 0.4 | -0.3 | 0.4 | -0.3 |
| Total locomotion distance, hab. session 1 | 0.1 | 0.2 | 0.8 | 0.2 | -0.5 | 0.0 | -0.5 | 0.9 | 0.2 | -0.2 | -0.3 | 0.1 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.3 | -0.1 | -0.1 | -0.2 | -0.2 | 0.5 | -0.1 | 0.1 | -0.5 | 0.2 |
| Time in familiar zone, hab. session 2 | 0.1 | 0.2 | 0.5 | 0.5 | -0.4 | 0.2 | -0.4 | 0.7 | 0.4 | -0.3 | 0.2 | -0.2 |
| Locomotion velocity, hab. session 2 | 0.1 | 0.2 | 0.5 | -0.5 | -0.3 | -0.3 | -0.4 | 0.5 | -0.1 | 0.1 | -0.7 | 0.5 |
| Total zone transitions, NPP test | 0.1 | 0.2 | 0.5 | -0.5 | -0.2 | -0.4 | -0.2 | 0.6 | -0.1 | 0.2 | -0.7 | 0.5 |
| Pavlov. Cond. intertrial magazine entries | 0.1 | 0.2 | 0.6 | 0.1 | -0.2 | -0.4 | -0.1 | 0.1 | -0.5 | 0.2 | -0.6 | 0.8 |
| Bone: apparent density | 0.1 | 0.2 | 0.4 | 0.4 | -0.2 | 0.4 | -0.3 | 0.6 | 0.5 | -0.5 | 0.3 | -0.5 |
| Distance traveled before self-admin | 0.1 | 0.2 | 1.0 | 0.0 | 0.3 | 0.0 | 0.3 | -1.0 | -0.4 | 0.1 | 0.1 | 0.1 |
| Delta time in closed arm before/after self-admin | 0.1 | 0.1 | 0.3 | -0.6 | 0.5 | -0.3 | 0.4 | -0.1 | 0.1 | 0.4 | -0.0 | -0.2 |
| Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.3 | 0.5 | -0.4 | 0.1 | -0.4 | -0.5 | -0.3 | -0.1 | 0.1 | -0.1 |
| Time in open arm after self-admin | 0.1 | 0.1 | 0.3 | 0.1 | 0.5 | 0.1 | 0.4 | -0.6 | 0.1 | -0.1 | 0.3 | -0.3 |
| Delta time to tail flick, test, before/after SA | 0.1 | 0.1 | 0.4 | 0.0 | 0.6 | -0.1 | 0.6 | -0.2 | 0.1 | 0.2 | 0.3 | -0.3 |
| Delay disc. indifference point, 16s delay | 0.1 | 0.1 | 0.3 | -0.2 | -0.1 | 0.2 | 0.0 | 0.2 | 0.4 | -0.1 | 0.5 | -0.2 |
| Delay disc. indifference point, 2s delay | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.4 | -0.2 | 0.4 | 0.2 | -0.3 | 0.3 | -0.2 |
| Delay discount exponential model param | 0.1 | 0.1 | 0.2 | 0.5 | -0.1 | 0.1 | -0.2 | -0.1 | 0.2 | -0.2 | 0.1 | -0.3 |
| Bouts of movement, locomotor time 1 | 0.1 | 0.1 | 0.4 | -0.6 | 0.3 | -0.2 | 0.0 | -0.3 | -0.4 | 0.3 | -0.3 | 0.4 |
| Distance moved, locomotor task time 1 | 0.1 | 0.1 | 0.4 | 0.6 | -0.3 | 0.1 | -0.4 | 0.4 | -0.2 | -0.3 | -0.2 | -0.0 |
| Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.3 | 0.5 | -0.4 | 0.2 | -0.3 | 0.2 | -0.2 | -0.4 | 0.1 | -0.1 |
| Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.2 | -0.4 | 0.3 | -0.2 | 0.4 | -0.2 | -0.1 | 0.3 | -0.0 | 0.2 |
| Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.3 | 0.5 | 0.1 | -0.1 | -0.1 | 0.5 | -0.4 | -0.1 | -0.5 | 0.5 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.6 | -0.2 | 0.8 | -0.5 | 0.4 | -0.1 | 0.2 | 0.3 | -0.3 | 0.0 |
| Co content in liver | 0.1 | 0.1 | 0.5 | -0.2 | -0.6 | 0.2 | -0.4 | 0.7 | 0.3 | -0.2 | 0.1 | -0.2 |
| Zn content in liver | 0.1 | 0.1 | 0.2 | 0.1 | -0.4 | 0.4 | -0.4 | 0.4 | 0.4 | -0.3 | 0.5 | -0.5 |
| Reaction time num false alarms AUC | 0.0 | 0.0 | 0.1 | 0.2 | -0.0 | -0.1 | 0.0 | 0.2 | 0.3 | -0.1 | -0.2 | 0.1 |
| Reaction time omissions | 0.0 | 0.0 | 0.2 | 0.4 | -0.0 | 0.1 | -0.3 | 0.1 | -0.1 | -0.2 | 0.1 | -0.1 |
| Saline control response | 0.0 | 0.1 | 0.2 | 0.0 | 0.4 | -0.1 | 0.3 | 0.2 | 0.3 | 0.1 | 0.1 | -0.2 |
| Conditioned reinforcement - actives | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.2 | 0.2 | -0.2 | -0.3 | 0.1 | -0.3 | 0.3 |
| Degree of sensitization distance | 0.0 | 0.0 | 0.1 | 0.1 | -0.0 | 0.1 | -0.2 | 0.2 | 0.2 | -0.1 | 0.1 | -0.1 |
| Bone: elastic displacement | 0.0 | 0.1 | 0.1 | -0.3 | 0.0 | -0.2 | 0.2 | -0.1 | -0.2 | 0.3 | -0.2 | 0.3 |
| Bone: elastic work | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | 0.1 | 0.1 | -0.2 | 0.1 | 0.0 | 0.3 | -0.1 |
| Bone: trabecular spacing | 0.0 | 0.1 | 0.2 | 0.0 | -0.2 | 0.3 | -0.2 | 0.5 | 0.3 | -0.2 | 0.2 | -0.0 |
| Breakpoint value in progressive ratio session | 0.0 | 0.0 | 0.1 | -0.1 | -0.3 | -0.1 | -0.4 | -0.3 | -0.1 | 0.0 | -0.2 | 0.1 |
| Time in closed arm after self-admin | 0.0 | 0.0 | 0.1 | -0.2 | -0.0 | -0.2 | 0.1 | -0.0 | -0.1 | 0.2 | -0.2 | 0.1 |
| Area under the delay curve | 0.0 | 0.0 | 0.2 | -0.5 | -0.0 | -0.0 | 0.1 | 0.1 | -0.2 | 0.2 | -0.0 | 0.3 |
| Delay discount hyperbolic model param | 0.0 | 0.0 | 0.1 | 0.3 | 0.0 | -0.1 | -0.0 | -0.1 | 0.1 | -0.1 | -0.1 | -0.1 |
| Total resting periods, locomotor time 1 | 0.0 | 0.0 | 0.2 | -0.5 | 0.3 | -0.0 | -0.0 | -0.1 | -0.1 | 0.1 | -0.1 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.