Hub : Genes

Bhlhe22

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000021745	0.07	0.05	3.1e-05	0.04	0.04	0.04	0.04	8.5e-05	9.4e-05	2.5e-04	1.3e-04
2	NAcc	gene expression	ENSRNOG00000021745	0.11	0.06	5.4e-07	0.07	0.06	0.06	0.06	6.0e-06	3.1e-05	1.6e-05	2.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	2.3	7.6	7.8	-2.8	2.7
BMI without tail	1.9	4.0	4.0	-2.0	2.0
Body weight	2.8	11.7	11.9	-3.4	3.4
Epididymis fat weight	5.7	13.4	13.9	-3.7	3.6
Glucose	0.6	0.9	1.0	-0.9	1.0
Heart weight	0.1	0.2	0.2	-0.4	0.4
Left kidney weight	0.0	0.0	0.0	0.0	0.0
Right kidney weight	0.7	2.0	2.1	-1.4	1.5
Tail length	0.6	1.9	2.0	-1.4	1.4
Length with tail	1.2	4.6	4.6	-2.1	2.1
Length without tail	0.8	1.9	1.9	-1.4	1.4
Liver weight, left	3.9	6.3	6.4	-2.5	2.5
Liver weight, right	2.4	3.9	3.9	-2.0	2.0
Parametrial fat weight	2.6	5.0	5.4	-2.3	2.2
Retroperitoneal fat weight	3.8	12.4	12.5	-3.5	3.5
Intraocular pressure	2.4	3.4	3.7	-1.9	1.8
Extensor digitorum longus weight	6.7	27.0	27.3	-5.2	5.2
Soleus weight	0.5	1.5	1.6	-1.2	1.3
Tibialis anterior weight	7.3	25.0	25.5	-5.0	5.0
Tibia length	0.1	0.3	0.4	-0.6	0.5
Number of licking bursts	2.6	3.1	3.1	-1.8	1.8
Food consumed during 24 hour testing period	4.0	4.8	4.8	-2.2	2.2
Times rat made contact with spout	4.3	4.9	4.9	-2.2	2.2
Mean time between licks in bursts	0.0	0.0	0.0	-0.2	0.2
Mean num. licks in bursts	0.3	0.3	0.3	0.6	-0.6
Std. dev. time between licks in bursts	0.9	1.0	1.0	1.0	-1.0
Water consumed over 24 hours	0.3	0.3	0.3	-0.6	0.6
Indifference point 0 sec	0.1	0.2	0.2	-0.5	0.5
Indifference point AUC	0.1	0.1	0.1	0.3	-0.3
Indifference point function ln k	1.1	1.5	1.6	-1.3	1.2
Indifference point function log k	1.1	1.5	1.6	-1.3	1.2
Delay discounting total patch changes 0 sec	0.4	0.6	0.6	-0.8	0.8
Delay discounting total patch changes 12 sec	0.0	0.0	0.0	-0.2	0.0
Delay discounting total patch changes 18 sec	0.0	0.0	0.0	-0.0	-0.0
Delay discounting total patch changes 24 sec	0.1	0.1	0.2	0.3	-0.4
Delay discounting total patch changes 6 sec	0.3	0.5	0.5	-0.7	0.7
Delay discounting time to switch 0 sec	0.3	0.5	0.6	-0.8	0.5
Delay discounting water rate 0 sec	0.1	0.2	0.3	0.5	-0.3
Delay discounting water rate 12 sec	1.9	2.8	2.9	1.6	-1.7
Delay discounting water rate 18 sec	1.4	1.9	1.9	1.4	-1.4
Delay discounting water rate 24 sec	0.3	0.4	0.5	0.7	-0.7
Delay discounting water rate 6 sec	0.0	0.0	0.0	0.2	-0.0
Locomotor activity	1.6	2.5	2.6	-1.6	1.6
Locomotor testing distance	2.0	3.4	3.5	-1.9	1.8
Locomotor testing rearing	0.1	0.1	0.1	-0.4	0.2
Light reinforcement 1	2.2	4.0	4.2	-2.1	2.0
Light reinforcement 2	4.9	6.5	6.6	-2.6	2.5
Reaction time number correct	0.7	1.0	1.1	1.1	-1.0
Reaction time mean minus median	4.9	6.3	6.7	-2.6	2.4
Reaction time mean minus median AUC	4.4	5.6	5.9	-2.4	2.3
Reaction time num false alarms	0.8	1.2	1.3	1.1	-1.0
Reaction time num false alarms AUC	0.4	0.6	0.6	0.8	-0.7
Reaction time trials correct on left	0.7	1.0	1.1	1.1	-1.0
Reaction time trials on left	0.6	0.9	1.0	1.0	-0.9
Reaction time mean	1.6	2.2	2.4	-1.6	1.4
Reaction time mean AUC	1.5	2.0	2.2	-1.5	1.3
Median of all reaction times	0.6	0.8	1.0	-1.0	0.8
Reaction time omissions	2.7	3.6	3.7	-1.9	1.9
Reaction time false alarm rate	0.0	0.0	0.0	0.2	-0.1
Reaction time premature initiation rate	0.2	0.3	0.3	0.6	-0.5
Reaction time premature initiations	0.5	0.6	0.7	0.8	-0.8
Std. dev. reaction times	3.7	5.1	5.4	-2.3	2.2
Reaction time trials completed	0.6	0.9	1.0	1.0	-0.9
Reaction time trials AUC	0.5	0.7	0.8	0.9	-0.8
Social response proportion	0.1	0.1	0.1	-0.3	0.3
Social responses	1.4	1.8	1.8	-1.4	1.3
Social time	0.4	0.5	0.5	0.7	-0.7
Conditioned locomotion	1.3	1.6	1.6	1.2	-1.3
Cocaine response after cond. corrected	0.3	0.3	0.3	0.6	-0.6
Cocaine response after cond. not corrected	0.3	0.3	0.3	0.6	-0.6
Cocaine response before conditioning	0.1	0.1	0.2	0.4	-0.4
Saline control response	0.5	0.6	0.6	-0.8	0.8
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.3	-0.5	0.6
Condit. Reinf. active responses	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	0.3
Condit. Reinf. lever presses	0.4	0.6	0.6	0.8	-0.7
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.2	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	0.0
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. response bias	0.0	0.1	0.1	0.3	-0.3
Conditioned reinforcement - actives	0.4	0.4	0.5	0.7	-0.5
Conditioned reinforcement - inactives	0.2	0.3	0.4	0.6	-0.4
Conditioned locomotion	0.6	0.7	0.8	-0.8	0.9
Intermittent access intake day 1-15 change	1.2	1.2	1.5	-0.9	1.2
Intermittent access intake escalation	0.5	0.5	0.7	-0.5	0.8
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.3	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.3	-0.1
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	0.8	-0.5
Intermitt. access escalation Index	0.3	0.3	0.4	0.4	-0.6
Intermittent access day 1 total infusions	0.3	0.3	0.4	0.6	-0.5
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.3	0.5
Intermittent access total infusions	0.1	0.1	0.1	0.3	-0.2
Intermittent access day 1 locomotion	0.7	0.7	0.8	-0.8	0.9
Intermittent access day 15 total locomotion	0.8	0.8	0.9	-0.9	0.9
Intermittent access total locomotion	0.9	1.1	1.2	-1.0	1.1
Intermittent access standard deviation	0.5	0.6	0.8	-0.5	0.9
Cocaine induced anxiety	0.1	0.1	0.1	0.4	-0.4
Post-drug Anxiety	0.8	0.9	0.9	1.0	-1.0
Baseline Anxiety	0.4	0.5	0.5	0.7	-0.7
Lifetime Intake	0.2	0.2	0.2	0.5	-0.4
Incentive Sensitization - Responses	1.1	1.1	1.1	1.0	-1.0
Incentive Sensitization - Breakpoint	1.0	1.0	1.0	1.0	-1.0
Progressive ratio test 1 active lever presses	0.4	0.5	0.5	-0.6	0.7
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.5	0.6	0.7	0.8	-0.7
Progressive ratio test 2 active lever presses	0.4	0.4	0.4	0.7	-0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.3	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	-0.2
Total sessions with >9 infusions	0.4	0.5	0.5	-0.7	0.7
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.2	-0.1
Short access day 10 total inactive lever presses	0.5	0.5	0.5	0.7	-0.7
Short access day 1 total infusions	2.1	2.2	2.2	-1.5	1.5
Short access day 10 total infusions	0.1	0.1	0.1	0.4	-0.3
Short access total infusions	0.1	0.1	0.1	0.3	-0.2
Short access day 1 locomotion	0.4	0.4	0.6	-0.6	0.7
Short access day 10 total locomotion	0.2	0.2	0.3	-0.4	0.6
Short access total locomotion	0.5	0.5	0.7	-0.7	0.8
Compulsive drug intake	1.3	1.3	1.3	1.1	-1.2
One hour access (0.3 mA shock)	1.7	1.9	2.2	1.5	-1.3
One hour access (shock baseline)	1.1	1.3	1.4	1.2	-1.1
Number of responses in last shaping day	2.8	2.9	2.9	-1.7	1.7
Context. condit. distance diff. score	0.6	0.7	0.7	-0.9	0.9
Locomotion velocity, session 1	0.3	0.3	0.3	-0.6	0.6
Locomotion distance, session 1	0.0	0.0	0.0	-0.2	0.2
Locomotion velocity, session 2	2.9	3.4	3.4	-1.8	1.8
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	0.1
Locomotion velocity, session 3	0.9	1.1	1.1	-1.0	1.0
Locomotion distance, session 3	0.6	0.6	0.6	-0.8	0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.4	-0.4
Stereotopy head waving duration, day 3	0.3	0.4	0.4	0.6	-0.6
Locomotion velocity, session 7	1.8	2.0	2.0	1.4	-1.4
Locomotion distance, session 7	2.1	2.7	2.7	1.6	-1.6
Stereotopy head waving bouts, day 7	0.8	0.9	0.9	-1.0	1.0
Stereotopy head waving duration, day 7	0.7	0.8	0.8	-0.9	0.9
Locomotion velocity, session 8	1.8	2.2	2.2	-1.5	1.5
Locomotion distance, session 8	1.8	2.6	2.6	-1.6	1.6
Degree of sensitization distance	4.5	4.6	4.6	2.1	-2.1
Degree of sensitization stereotypy	3.9	4.2	4.2	-2.1	2.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	0.1
Condit. Reinf. active responses	0.1	0.2	0.2	-0.4	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.3	-0.5	0.5
Incentive salience index mean	0.2	0.3	0.3	-0.5	0.5
Condit. Reinf. lever presses	0.2	0.2	0.2	-0.5	0.5
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.1	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.2	-0.5	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.1	-0.4	0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.5	0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.4	-0.6	0.6
Time in familiar zone, hab. session 2	0.7	0.7	0.7	0.8	-0.8
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3
Total zone transitions, hab. session 2	0.7	0.8	0.8	-0.9	0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.4	0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.5	0.5
Novel to familiar place preference ratio	2.0	2.1	2.1	1.5	-1.5
Novelty place preference	1.8	1.9	1.9	1.4	-1.4
Time in novel zone, NPP test	1.4	1.5	1.5	1.2	-1.2
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	0.3
Total locomotion distance, NPP test	0.1	0.2	0.2	-0.4	0.4
Locomotion velocity, NPP test	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.3	-0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. change in total contacts	1.5	1.6	1.6	-1.3	1.3
Pavlov. Cond. index score	0.7	0.9	0.9	-0.9	0.9
Pavlov. Cond. latency score	0.5	0.6	0.6	-0.8	0.8
Pavlov. Cond. lever contacts	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. magazine entry number	0.7	0.9	0.9	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.4	-1.2	1.2
Pavlov. Cond. response bias	0.6	0.8	0.8	-0.9	0.9
Bone: apparent density	2.2	3.6	3.6	1.9	-1.9
Bone surface	0.1	0.3	0.3	0.5	-0.5
Bone volume	0.3	0.6	0.6	0.8	-0.8
Bone: connectivity density	2.4	3.7	3.7	1.9	-1.9
Bone: cortical apparent density	1.4	1.9	1.9	-1.4	1.4
Bone: cortical area	0.3	0.4	0.4	-0.7	0.7
Bone: cortical porosity	0.5	0.5	0.5	0.7	-0.7
Bone: cortical porosity	0.2	0.2	0.2	0.4	-0.4
Bone: cortical thickness	0.0	0.1	0.1	0.3	-0.3
Bone: cortical thickness	1.0	1.2	1.2	-1.1	1.1
Bone: cortical tissue density	1.5	2.0	2.0	-1.4	1.4
Bone: elastic displacement	4.4	5.0	5.0	2.2	-2.2
Bone: elastic work	1.6	2.1	2.1	1.4	-1.4
Bone: endosteal estimation	1.3	2.8	2.8	-1.7	1.7
Bone: endosteal perimeter	2.0	4.2	4.2	-2.1	2.1
Bone: final force	1.6	2.6	2.6	-1.6	1.6
Bone: final moment	1.3	2.1	2.1	-1.5	1.5
Bone: marrow area	1.2	2.7	2.7	-1.6	1.6
Bone: maximum diameter	0.9	1.6	1.6	-1.3	1.3
Bone: maximum force	1.3	2.3	2.3	-1.5	1.5
Bone: maximum moment	1.0	1.8	1.8	-1.3	1.3
Bone: minimum diameter	0.1	0.3	0.3	-0.5	0.5
Bone: periosteal estimation	0.9	1.9	1.9	-1.4	1.4
Bone: periosteal perimeter	1.3	2.2	2.2	-1.5	1.5
Bone: post-yield work	1.0	1.4	1.4	-1.2	1.2
Bone: stiffness	2.9	4.6	4.6	-2.1	2.1
Bone: tissue strength	0.0	0.0	0.0	0.1	-0.1
Bone: trabecular number	2.2	3.4	3.4	1.9	-1.9
Bone: trabecular spacing	0.2	0.2	0.2	-0.4	0.4
Bone: trabecular thickness	1.7	2.1	2.1	1.5	-1.5
Bone: trabecular tissue density	2.6	3.6	3.6	-1.9	1.9
Breakpoint value in progressive ratio session	0.4	0.5	0.6	-0.5	0.8
Distance traveled before self-admin	4.2	4.5	4.8	-2.0	2.2
Distance traveled after self-admin	4.4	4.8	5.2	-2.1	2.3
Delta time in closed arm before/after self-admin	0.4	0.3	0.4	0.6	-0.6
Delta time in open arm before/after self-admin	1.7	1.6	1.7	-1.3	1.3
Diff in mean of infusions in LGA sessions	1.1	1.3	1.3	1.1	-1.2
Extinction: sum of active levers before priming	3.4	3.5	3.6	-1.8	1.9
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.2	0.1
Delta distance traveled before/after self-admin	0.4	0.4	0.5	0.6	-0.7
Delta ambulatory time before/after self-admin	0.9	1.0	1.1	1.1	-1.0
Time in closed arm before self-admin	0.5	0.5	0.5	0.7	-0.7
Time in closed arm after self-admin	0.6	0.6	0.7	0.8	-0.7
Time in open arm before self-admin	0.3	0.3	0.4	0.6	-0.5
Time in open arm after self-admin	2.9	3.2	3.3	-1.8	1.8
Sum of active levers in priming session hrs 5-6	2.0	1.9	2.1	-1.3	1.4
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.0	-0.2
Time to tail flick, vehicle, after self-admin	3.0	3.2	3.5	1.7	-1.9
Time to tail flick, test, before self-admin	0.4	0.4	0.5	-0.5	0.7
Time to tail flick, test, after self-admin	2.7	2.8	3.0	1.7	-1.6
Delta time to tail flick, vehicle, before/after SA	5.4	5.2	5.3	2.3	-2.3
Delta time to tail flick, test, before/after SA	1.1	1.0	1.1	0.9	-1.1
Ambulatory time before self-admin	4.8	5.0	5.2	-2.2	2.3
Ambulatory time after self-admin	1.2	1.3	1.6	-1.1	1.2
Total heroin consumption	0.2	0.2	0.3	-0.5	0.5
Area under the delay curve	1.3	1.4	1.4	-1.2	1.1
Delay disc. indifference point, 0s delay	0.4	0.4	0.5	-0.7	0.6
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	0.2
Delay disc. indifference point, 2s delay	0.9	1.0	1.0	-1.0	1.0
Delay disc. indifference point, 24s delay	0.6	0.6	0.6	0.8	-0.8
Delay disc. indifference point, 4s delay	2.1	2.2	2.2	-1.5	1.5
Delay disc. indifference point, 8s delay	1.0	1.0	1.1	-1.0	1.0
Delay discount exponential model param	1.1	1.2	1.2	1.1	-1.1
Delay discount hyperbolic model param	1.3	1.4	1.4	1.2	-1.2
Fecal boli incidents, locomotor time 1	0.8	0.9	1.1	-0.9	1.0
Change in fecal boli incidents, locomotor task	1.0	1.0	1.0	1.0	-1.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	0.1
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	0.0
Rest time, locomotor task time 1	0.2	0.3	0.3	-0.5	0.5
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.3	0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.1	-0.3	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.0	-0.2
Bouts of movement, locomotor time 2	0.8	0.8	0.9	0.9	-0.9
Total resting periods, locomotor time 2	0.5	0.5	0.6	0.7	-0.8
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.2	-0.3
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.4	0.3
Weight adjusted by age	0.8	0.9	1.0	-1.0	0.9
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	2.5	1.6	-1.4
Locomotion in novel chamber	0.2	0.2	0.2	-0.5	0.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	-0.2
Progressive ratio	0.3	0.3	0.4	0.6	-0.5
Food seeking constrained by brief footshock	1.2	1.5	1.5	1.2	-1.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.3	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.3	-0.6	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	-0.4
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.0	-0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.1	-0.1
Latency to leave start box in cocaine runway, M	0.7	0.6	0.7	-0.8	0.8
Cd content in liver	0.5	0.6	0.7	-0.7	0.8
Co content in liver	1.4	1.6	1.7	-1.3	1.3
Cu content in liver	0.0	0.0	0.0	0.1	-0.2
Fe content in liver	0.0	0.1	0.1	0.2	-0.3
K content in liver	0.1	0.1	0.1	0.4	-0.3
Mg content in liver	0.4	0.4	0.4	0.6	-0.6
Mn content in liver	0.0	0.1	0.1	0.2	-0.3
Na content in liver	1.5	1.6	1.7	-1.3	1.3
Rb content in liver	1.2	1.5	1.6	1.3	-1.2
Se content in liver	0.1	0.1	0.2	0.3	-0.4
Sr content in liver	1.1	1.0	1.0	1.0	-1.0
Zn content in liver	0.1	0.1	0.1	0.3	-0.4