Hub : Genes

RGD1559600

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000042232	0.28	0.11	0.0e+00	0.14	0.17	0.16	0.17	4.8e-15	1.2e-18	8.2e-18	3.7e-18
2	Liver	intron excision ratio	chr1:173974388:173985543	0.51	0.31	3.8e-04	0.01	0	0	0.01	1.3e-02	8.3e-02	2.4e-01	3.5e-02
3	Liver	intron excision ratio	chr1:173974388:173987413	0.53	0.25	2.8e-03	0.01	-0	0	0.01	3.5e-02	8.9e-01	1.3e-01	3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	2.4	7.8	8.4	2.7	2.9	-2.8
BMI without tail	7.8	16.3	19.0	3.4	4.3	-4.4
Body weight	2.2	9.1	11.5	2.3	3.3	-3.4
Epididymis fat weight	1.0	2.3	3.1	1.8	1.5	-1.2
Glucose	0.2	0.3	0.7	0.8	0.4	-0.0
Heart weight	0.3	0.4	1.1	1.1	0.1	0.4
Left kidney weight	4.5	12.8	13.9	3.3	3.7	-3.7
Right kidney weight	4.4	12.4	14.4	3.1	3.7	-3.8
Tail length	2.6	7.9	10.3	2.1	3.0	-3.2
Length with tail	0.4	1.5	2.5	0.6	1.3	-1.6
Length without tail	0.8	1.7	2.5	-1.6	-1.2	1.0
Liver weight, left	0.1	0.1	0.2	0.5	0.3	-0.3
Liver weight, right	0.1	0.1	0.3	-0.0	0.3	-0.5
Parametrial fat weight	3.8	7.5	10.3	3.2	2.6	-2.3
Retroperitoneal fat weight	0.3	1.0	2.8	1.7	0.5	0.0
Intraocular pressure	0.0	0.1	0.1	-0.0	0.2	-0.4
Extensor digitorum longus weight	4.3	17.2	27.1	2.1	4.5	-5.2
Soleus weight	2.4	6.9	7.4	2.5	2.7	-2.6
Tibialis anterior weight	7.5	25.9	32.6	3.8	5.6	-5.7
Tibia length	0.0	0.1	0.2	0.4	-0.2	0.4
Number of licking bursts	6.1	7.3	8.4	-2.3	-2.9	2.9
Food consumed during 24 hour testing period	2.3	2.7	3.0	1.5	1.7	-1.7
Times rat made contact with spout	1.7	1.9	3.0	0.7	1.5	-1.7
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	0.1
Mean num. licks in bursts	8.9	10.7	13.2	2.6	3.5	-3.6
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.5	0.1	0.1
Water consumed over 24 hours	0.9	1.0	2.5	-1.6	-0.7	0.2
Indifference point 0 sec	0.8	1.3	1.7	1.2	1.3	-0.9
Indifference point AUC	1.0	1.2	2.7	1.6	0.8	-0.5
Indifference point function ln k	0.7	1.0	1.5	0.4	1.2	-1.2
Indifference point function log k	0.7	1.0	1.5	0.4	1.2	-1.2
Delay discounting total patch changes 0 sec	1.1	1.8	2.2	1.5	1.5	-1.0
Delay discounting total patch changes 12 sec	0.3	0.3	0.4	0.7	0.6	-0.4
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	0.4	0.1	0.2
Delay discounting total patch changes 24 sec	0.7	0.9	1.5	1.2	0.9	-0.7
Delay discounting total patch changes 6 sec	0.5	0.7	1.6	1.3	0.0	0.8
Delay discounting time to switch 0 sec	3.4	5.1	8.9	-3.0	-2.1	1.5
Delay discounting water rate 0 sec	0.3	0.5	0.6	0.8	0.7	-0.6
Delay discounting water rate 12 sec	1.1	1.6	2.4	1.5	1.3	-1.0
Delay discounting water rate 18 sec	0.2	0.3	0.5	0.7	0.4	-0.3
Delay discounting water rate 24 sec	0.3	0.4	0.6	0.7	0.5	-0.5
Delay discounting water rate 6 sec	0.3	0.5	1.3	1.2	0.3	0.2
Locomotor activity	0.0	0.0	0.1	-0.2	-0.2	0.2
Locomotor testing distance	0.1	0.2	0.4	0.6	0.5	-0.3
Locomotor testing rearing	0.1	0.2	0.4	-0.2	-0.5	0.6
Light reinforcement 1	0.1	0.2	0.4	-0.0	-0.4	0.7
Light reinforcement 2	0.1	0.1	0.2	0.5	0.2	0.1
Reaction time number correct	1.1	1.5	1.7	-1.2	-1.3	1.2
Reaction time mean minus median	0.3	0.4	0.7	0.9	0.6	-0.3
Reaction time mean minus median AUC	0.2	0.3	0.6	0.8	0.4	-0.0
Reaction time num false alarms	1.1	1.5	2.1	-0.6	-1.3	1.5
Reaction time num false alarms AUC	0.8	1.2	1.5	-0.7	-1.2	1.2
Reaction time trials correct on left	1.1	1.5	1.7	-1.2	-1.3	1.2
Reaction time trials on left	1.1	1.5	1.7	-1.2	-1.3	1.2
Reaction time mean	0.3	0.3	0.8	0.9	0.4	-0.3
Reaction time mean AUC	0.1	0.1	0.2	0.5	0.1	-0.1
Median of all reaction times	0.1	0.2	0.5	0.7	0.2	-0.2
Reaction time omissions	0.4	0.5	0.8	-0.9	-0.7	0.5
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	-0.4	0.4
Reaction time premature initiation rate	1.2	1.5	2.9	-0.1	1.3	-1.7
Reaction time premature initiations	0.5	0.7	0.9	-1.0	0.5	-0.9
Std. dev. reaction times	0.4	0.5	0.9	1.0	0.6	-0.5
Reaction time trials completed	1.1	1.5	1.7	-1.2	-1.3	1.2
Reaction time trials AUC	0.8	1.2	1.3	-1.1	-1.2	1.0
Social response proportion	0.2	0.2	0.3	0.4	-0.2	0.6
Social responses	0.4	0.5	1.0	-0.4	-0.7	1.0
Social time	0.5	0.7	0.9	-0.7	-0.9	1.0
Conditioned locomotion	0.4	0.4	1.2	-1.1	-0.1	-0.3
Cocaine response after cond. corrected	0.2	0.3	0.4	-0.3	-0.6	0.6
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.0	0.0	-0.2
Cocaine response before conditioning	1.9	2.3	3.9	0.6	1.7	-2.0
Saline control response	0.1	0.1	0.3	0.1	-0.3	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.8	1.3	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.0	0.9	-0.5	1.0
Condit. Reinf. active responses	0.3	0.4	1.0	1.0	0.4	-0.2
Condit. Reinf. inactive responses	1.1	1.3	2.6	0.1	1.2	-1.6
Condit. Reinf. lever presses	1.1	1.6	1.7	1.3	1.3	-1.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	0.7	0.1	0.1
Pavlov. Cond. lever latency	1.0	1.3	1.4	-1.2	-1.2	1.1
Pavlov. Cond. magazine entry latency	1.9	2.2	3.2	-1.8	-1.5	1.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.8	-0.1	0.5
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.2	0.1
Pavlov. Cond. lever contacts	1.0	1.4	1.5	1.1	1.2	-1.2
Pavlov. Cond. magazine entry number	2.1	2.6	2.9	1.5	1.7	-1.6
Pavlov. Cond. intertrial magazine entries	2.6	3.3	3.6	1.7	1.9	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.4	-0.5	0.4
Pavlov. Cond. response bias	0.0	0.0	0.1	0.2	0.1	-0.1
Conditioned reinforcement - actives	1.1	1.0	1.5	0.9	1.2	-1.0
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.4	0.3	0.1
Conditioned locomotion	0.2	0.2	0.3	-0.5	0.4	-0.4
Intermittent access intake day 1-15 change	0.2	0.2	0.2	-0.3	-0.4	0.5
Intermittent access intake escalation	0.2	0.2	0.3	-0.1	-0.4	0.5
Intermittent access intake escalation 2	0.8	0.8	1.1	-0.3	-1.0	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.0	-0.2	0.3
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.8	0.6	1.2	-1.3
Intermitt. access escalation Index	1.5	1.3	2.3	1.5	1.0	-0.8
Intermittent access day 1 total infusions	1.2	1.3	1.8	0.8	1.3	-1.2
Intermittent access day 15 total infusions	0.4	0.5	0.6	0.7	0.8	-0.5
Intermittent access terminal intake (last 3 days)	0.5	0.5	0.6	0.8	0.8	-0.5
Intermittent access total infusions	1.7	1.9	2.6	1.2	1.6	-1.4
Intermittent access day 1 locomotion	1.1	1.2	1.7	1.3	1.1	-0.8
Intermittent access day 15 total locomotion	0.5	0.5	1.0	1.0	0.1	0.8
Intermittent access total locomotion	1.6	1.8	3.6	1.9	1.2	-0.5
Intermittent access standard deviation	0.2	0.2	0.5	0.7	0.3	-0.3
Cocaine induced anxiety	0.4	0.4	0.7	0.5	-0.6	0.8
Post-drug Anxiety	0.7	0.8	1.4	0.4	-0.9	1.2
Baseline Anxiety	0.3	0.3	0.5	0.4	0.6	-0.7
Lifetime Intake	2.6	2.9	3.8	1.4	2.0	-1.8
Incentive Sensitization - Responses	0.7	0.7	0.9	-0.4	1.0	-1.0
Incentive Sensitization - Breakpoint	0.8	0.8	1.2	-0.2	1.1	-1.1
Progressive ratio test 1 active lever presses	0.7	0.7	1.0	0.8	1.0	-0.8
Progressive ratio test 1 breakpoint	0.6	0.6	0.8	0.7	0.9	-0.7
Progressive ratio test 1 inactive lever presses	1.6	1.7	2.5	1.0	1.6	-1.3
Progressive ratio test 2 active lever presses	0.6	0.7	1.1	0.3	1.1	-0.9
Progressive ratio test 2 breakpoint	0.7	0.8	1.4	0.4	1.2	-1.0
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.1	0.5	1.0	-0.7
Total sessions with >9 infusions	5.8	6.4	8.9	1.5	2.8	-3.0
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.1	0.5	-0.4
Short access day 10 total inactive lever presses	0.4	0.4	0.6	-0.4	-0.7	0.8
Short access day 1 total infusions	1.3	1.4	1.9	0.6	1.4	-1.4
Short access day 10 total infusions	2.7	3.0	4.3	0.8	2.0	-2.1
Short access total infusions	3.7	4.1	5.4	1.5	2.3	-2.2
Short access day 1 locomotion	0.4	0.4	0.6	0.1	0.8	-0.7
Short access day 10 total locomotion	2.1	2.3	3.5	1.9	1.4	-1.2
Short access total locomotion	3.0	3.1	4.4	2.1	1.8	-1.3
Compulsive drug intake	0.0	0.0	0.1	0.3	0.1	0.1
One hour access (0.3 mA shock)	2.5	2.9	4.3	2.1	1.6	-1.3
One hour access (shock baseline)	0.2	0.2	0.4	0.7	-0.0	0.3
Number of responses in last shaping day	0.2	0.2	0.5	-0.0	0.5	-0.7
Context. condit. distance diff. score	0.7	0.9	1.2	-0.7	-1.1	1.0
Locomotion velocity, session 1	0.0	0.0	0.0	0.1	-0.0	-0.2
Locomotion distance, session 1	0.5	0.7	0.8	0.8	0.8	-0.9
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	-0.2	0.1
Locomotion distance, session 2	1.6	2.4	3.1	1.2	1.6	-1.8
Locomotion velocity, session 3	0.2	0.3	0.5	0.3	0.5	-0.7
Locomotion distance, session 3	0.2	0.2	0.5	-0.3	0.3	-0.7
Stereotopy head waving bouts, day 3	0.4	0.4	0.7	-0.5	-0.6	0.8
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.2	-0.4	0.6
Locomotion velocity, session 7	0.8	0.9	2.2	-0.3	0.7	-1.5
Locomotion distance, session 7	0.4	0.6	1.0	-1.0	-0.8	0.2
Stereotopy head waving bouts, day 7	0.8	0.9	1.3	0.6	1.1	-1.1
Stereotopy head waving duration, day 7	2.7	3.3	4.1	1.3	2.0	-2.0
Locomotion velocity, session 8	0.0	0.0	0.1	0.0	0.1	-0.3
Locomotion distance, session 8	0.0	0.0	0.1	0.2	0.0	-0.3
Degree of sensitization distance	0.8	0.8	1.6	0.1	-0.9	1.3
Degree of sensitization stereotypy	3.0	3.3	4.7	1.0	2.1	-2.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.3	-0.4	0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	-0.1	0.1
Condit. Reinf. active responses	0.2	0.3	0.5	0.1	-0.5	0.7
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.4	-0.5	0.8
Incentive salience index mean	0.0	0.0	0.1	-0.3	-0.1	-0.0
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.7	-0.5	0.3
Time in familiar zone, hab. session 1	0.6	0.6	1.1	0.6	-0.6	1.0
Time in novel zone, hab. session 1	1.4	1.3	2.4	-1.0	0.8	-1.6
Total zone transitions, hab. session 1	3.4	4.8	5.4	2.3	2.1	-2.1
Total locomotion distance, hab. session 1	6.0	8.7	9.3	3.0	3.0	-2.8
Locomotion velocity, hab. session 1	4.6	6.6	8.8	3.0	2.5	-2.2
Time in familiar zone, hab. session 2	0.4	0.4	0.7	0.8	0.6	-0.4
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	0.2
Total zone transitions, hab. session 2	2.8	3.6	3.8	1.9	1.9	-1.8
Total locomotion distance, hab. session 2	3.2	4.3	4.5	2.1	2.1	-2.0
Locomotion velocity, hab. session 2	3.9	5.2	5.4	2.3	2.3	-2.2
Novel to familiar place preference ratio	0.4	0.4	0.9	-0.2	-0.6	1.0
Novelty place preference	0.5	0.5	1.0	-0.3	-0.7	1.0
Time in novel zone, NPP test	0.5	0.5	1.0	-0.1	-0.6	1.0
Total zone transitions, NPP test	2.1	3.0	3.2	1.7	1.8	-1.8
Total locomotion distance, NPP test	1.8	2.5	3.2	1.8	1.6	-1.4
Locomotion velocity, NPP test	1.4	2.0	2.5	1.6	1.4	-1.3
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.6	-0.2	0.7
Pavlov. Cond. magazine entry latency	0.9	1.2	2.3	0.2	1.1	-1.5
Pavlov. Cond. change in total contacts	0.6	0.6	1.3	-1.2	-0.0	-0.7
Pavlov. Cond. index score	0.3	0.4	0.8	-0.6	0.4	-0.9
Pavlov. Cond. latency score	0.3	0.4	0.8	-0.3	0.4	-0.9
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-0.6	0.4	-1.0
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	0.7	-0.4	1.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.9	0.2	-0.8	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.2	-0.3	0.6	-1.1
Pavlov. Cond. response bias	0.6	0.8	1.2	-1.0	0.4	-1.1
Bone: apparent density	1.0	1.6	1.8	1.1	1.3	-1.3
Bone surface	0.9	1.5	2.6	0.6	1.3	-1.6
Bone volume	1.6	2.7	3.6	1.3	1.7	-1.9
Bone: connectivity density	0.4	0.7	0.9	0.6	0.8	-1.0
Bone: cortical apparent density	0.6	0.8	1.2	-0.6	-1.0	1.1
Bone: cortical area	3.7	5.6	7.0	1.8	2.6	-2.6
Bone: cortical porosity	0.9	1.0	1.5	0.5	1.1	-1.2
Bone: cortical porosity	0.2	0.2	0.4	0.0	0.5	-0.7
Bone: cortical thickness	1.9	3.1	3.5	1.6	1.9	-1.8
Bone: cortical thickness	0.4	0.5	0.8	0.9	0.7	-0.5
Bone: cortical tissue density	0.7	0.9	1.2	-0.7	-1.0	1.1
Bone: elastic displacement	0.2	0.2	0.5	-0.1	-0.4	0.7
Bone: elastic work	0.3	0.4	0.5	0.5	0.7	-0.7
Bone: endosteal estimation	1.4	3.0	4.5	1.0	1.8	-2.1
Bone: endosteal perimeter	0.8	1.6	2.9	0.4	1.3	-1.7
Bone: final force	6.5	10.6	12.0	2.8	3.5	-3.4
Bone: final moment	5.5	9.0	10.1	2.7	3.2	-3.1
Bone: marrow area	1.2	2.5	3.9	0.9	1.7	-2.0
Bone: maximum diameter	2.0	3.7	4.5	1.5	2.0	-2.1
Bone: maximum force	5.1	8.9	10.5	2.5	3.2	-3.2
Bone: maximum moment	4.2	7.4	8.5	2.3	2.9	-2.9
Bone: minimum diameter	2.2	4.0	6.1	1.1	2.1	-2.5
Bone: periosteal estimation	3.2	6.6	9.0	1.8	2.8	-3.0
Bone: periosteal perimeter	1.6	2.7	3.8	1.1	1.7	-1.9
Bone: post-yield work	2.3	3.1	3.5	1.5	1.9	-1.8
Bone: stiffness	4.5	7.1	8.0	2.3	2.8	-2.8
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.0	-0.2
Bone: trabecular number	0.8	1.2	1.3	1.0	1.1	-1.1
Bone: trabecular spacing	0.8	1.0	1.4	-1.2	-1.0	0.8
Bone: trabecular thickness	2.9	3.5	6.0	2.4	1.7	-1.3
Bone: trabecular tissue density	0.1	0.1	0.2	0.5	0.2	-0.0
Breakpoint value in progressive ratio session	0.5	0.5	0.6	-0.8	-0.6	0.8
Distance traveled before self-admin	0.1	0.1	0.2	0.2	0.3	-0.4
Distance traveled after self-admin	0.6	0.7	1.0	0.7	0.8	-1.0
Delta time in closed arm before/after self-admin	0.5	0.5	1.2	-1.1	-0.5	0.1
Delta time in open arm before/after self-admin	3.3	3.1	5.8	2.4	1.5	-1.1
Diff in mean of infusions in LGA sessions	0.6	0.6	0.9	0.9	-0.4	1.0
Extinction: sum of active levers before priming	0.4	0.4	0.5	-0.3	-0.7	0.7
Active lever presses in extinction session 6	0.1	0.1	0.1	0.4	0.2	0.2
Delta distance traveled before/after self-admin	0.8	0.8	1.2	0.6	0.9	-1.1
Delta ambulatory time before/after self-admin	0.7	0.8	1.2	0.7	0.9	-1.1
Time in closed arm before self-admin	1.1	1.3	1.4	1.2	1.2	-1.0
Time in closed arm after self-admin	0.4	0.4	0.8	-0.3	-0.7	0.9
Time in open arm before self-admin	3.3	3.5	4.0	-1.7	-2.0	1.9
Time in open arm after self-admin	0.9	1.0	1.5	1.2	0.9	-0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	-0.3	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.4	0.2	-0.3
Time to tail flick, vehicle, after self-admin	0.8	0.9	1.0	-1.0	-1.0	0.8
Time to tail flick, test, before self-admin	0.5	0.5	0.8	-0.0	0.8	-0.9
Time to tail flick, test, after self-admin	0.4	0.4	0.6	-0.7	-0.8	0.5
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.0	-0.4	0.3
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	0.1	-0.0
Ambulatory time after self-admin	0.6	0.6	1.1	0.5	0.7	-1.1
Total heroin consumption	0.3	0.4	0.4	-0.6	-0.6	0.7
Area under the delay curve	0.1	0.1	0.1	-0.2	-0.4	0.2
Delay disc. indifference point, 0s delay	0.7	0.8	1.3	0.5	0.9	-1.1
Delay disc. indifference point, 16s delay	3.9	3.9	5.3	-1.4	-2.1	2.3
Delay disc. indifference point, 2s delay	3.5	3.9	4.9	1.7	2.0	-2.2
Delay disc. indifference point, 24s delay	2.5	2.4	2.7	-1.4	-1.6	1.6
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.5	0.1	-0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.1	0.3	-0.5
Delay discount exponential model param	0.1	0.2	0.2	0.3	0.5	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	0.2	-0.1
Fecal boli incidents, locomotor time 1	0.8	0.9	1.9	-1.4	-0.7	0.4
Change in fecal boli incidents, locomotor task	0.8	0.7	1.6	1.3	0.7	-0.5
Time >=10cm from walls, locomotor time 1	1.5	1.5	1.9	0.9	1.4	-1.4
Bouts of movement, locomotor time 1	3.3	3.7	5.2	-1.1	-2.1	2.3
Total resting periods, locomotor time 1	4.1	4.5	5.5	-1.7	-2.3	2.3
Rest time, locomotor task time 1	2.5	2.7	4.8	-2.2	-1.5	1.0
Distance moved, locomotor task time 1	3.1	3.4	5.6	2.4	1.7	-1.2
Vertical activity count, locomotor time 1	5.1	5.3	8.5	2.9	2.2	-1.6
Time >=10cm from walls, locomotor time 2	3.7	3.9	5.8	1.0	2.2	-2.4
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.4	0.1	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.3	0.3	-0.6
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.2	0.0	-0.1
Distance moved, locomotor task time 2	0.7	0.8	0.9	0.9	1.0	-0.9
Vertical activity count, locomotor time 2	1.1	1.2	2.1	1.4	1.0	-0.6
Weight adjusted by age	0.1	0.1	0.2	0.4	0.1	-0.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	-0.2	0.2
Locomotion in novel chamber	0.7	0.9	1.9	1.4	0.8	-0.4
Locomotion in novel chamber post-restriction	1.0	1.2	2.4	0.5	-1.0	1.5
Progressive ratio	0.1	0.1	0.2	0.4	0.0	0.3
Food seeking constrained by brief footshock	1.3	1.6	2.1	-0.9	-1.3	1.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.4	-0.1	-0.3
Run reversals in cocaine runway, females	4.4	4.3	6.3	1.5	2.1	-2.5
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	-0.0	0.1
Latency to leave start box in cocaine runway	0.1	0.2	0.4	0.6	0.1	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	-0.3	0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.2	1.1	0.3	0.2
Cd content in liver	4.4	4.8	6.9	-1.5	-2.3	2.6
Co content in liver	0.5	0.6	1.2	0.3	-0.7	1.1
Cu content in liver	0.5	0.7	1.7	1.3	0.5	-0.1
Fe content in liver	0.9	1.1	1.9	0.1	-1.2	1.4
K content in liver	0.1	0.1	0.3	0.5	0.2	0.0
Mg content in liver	0.1	0.1	0.2	-0.2	-0.3	0.4
Mn content in liver	0.2	0.2	0.4	-0.1	0.5	-0.6
Na content in liver	4.1	4.3	6.9	1.0	2.2	-2.6
Rb content in liver	0.7	0.8	1.5	0.8	-0.6	1.2
Se content in liver	0.1	0.2	0.4	0.6	0.2	-0.2
Sr content in liver	0.5	0.5	0.6	0.5	0.8	-0.7
Zn content in liver	2.6	2.9	3.7	1.3	1.9	-1.9