Hub : Traits

Times rat made contact with spout

The number of times the rat made contact with the spout, note that the spout was recessed to minimize non-tongue contact.

Tags: Behavior

Project: ny_derek_water_staging

2 significantly associated models · 1 unique gene

Significant Loci

#	chr	p0	p1	# assoc genes	# joint models	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	7	16845355	16970279	1	1	4.4e-32	NaN	NA	NA	NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Locomotion distance, session 2	776.0	1	1	100	1	NA
Total zone transitions, hab. session 1	415.6	1	1	100	1	NA
Locomotion distance, session 1	374.7	1	1	100	1	NA
Total zone transitions, hab. session 2	256.1	1	1	100	1	NA
Total zone transitions, NPP test	228.8	1	1	100	1	NA
Locomotion velocity, hab. session 1	218.6	1	1	100	1	NA
Locomotion velocity, NPP test	195.9	1	1	100	1	NA
Std. dev. time between licks in bursts	177.7	1	1	100	1	NA
Delay discounting total patch changes 18 sec	175.3	1	1	100	1	NA
Total locomotion distance, hab. session 1	171.4	1	1	100	1	NA
Mean num. licks in bursts	164.2	1	1	100	1	NA
Total locomotion distance, NPP test	163.4	1	1	100	1	NA
Number of licking bursts	155.0	1	1	100	1	NA
Pavlov. Cond. magazine entry number	150.0	1	1	100	1	NA
Context. condit. distance diff. score	149.8	1	1	100	1	NA
Degree of sensitization distance	140.6	1	1	100	1	NA
Cd content in liver	140.5	1	1	100	1	NA
Locomotion velocity, hab. session 2	139.4	1	1	100	1	NA
Total locomotion distance, hab. session 2	133.1	1	1	100	1	NA
Mn content in liver	130.2	1	1	100	1	NA
Pavlov. Cond. change in total contacts	130.1	1	1	100	1	NA
Locomotion velocity, session 1	117.8	1	1	100	1	NA
Locomotion velocity, session 3	116.1	1	1	100	1	NA
Bone: cortical porosity	109.3	1	1	100	1	NA
BMI without tail	106.7	1	1	100	1	NA
Pavlov. Cond. magazine entry latency	104.9	1	1	100	1	NA
Locomotion distance, session 8	102.8	1	1	100	1	NA
Delay discounting total patch changes 12 sec	102.7	1	1	100	1	NA
Cocaine response after cond. not corrected	102.3	1	1	100	1	NA
Delay discounting total patch changes 6 sec	98.5	1	1	100	1	NA
Bone: cortical porosity	91.2	1	1	100	1	NA
Bone: stiffness	90.4	1	1	100	1	NA
Epididymis fat weight	87.6	1	1	100	1	NA
Co content in liver	83.2	1	1	100	1	NA
Bone: post-yield work	82.8	1	1	100	1	NA
Intermittent access intake escalation	82.5	1	1	100	1	NA
Locomotion distance, session 3	82.4	1	1	100	1	NA
Locomotion velocity, session 2	82.2	1	1	100	1	NA
Bone: tissue strength	81.0	1	1	100	1	NA
Reaction time num false alarms AUC	79.5	1	1	100	1	NA
Cocaine response after cond. corrected	78.0	1	1	100	1	NA
Social responses	74.3	1	1	100	1	NA
Length without tail	71.1	1	1	100	1	NA
Pavlov. Cond. latency score	67.1	1	1	100	1	NA
Locomotion velocity, session 7	66.3	1	1	100	1	NA
Condit. Reinf. active-inactive response ratio	65.1	1	1	100	1	NA
Pavlov. Cond. intertrial magazine entries	63.9	1	1	100	1	NA
Reaction time false alarm rate	63.4	1	1	100	1	NA
Stereotopy head waving duration, day 7	63.4	1	1	100	1	NA
Delay discounting water rate 24 sec	62.7	1	1	100	1	NA
K content in liver	62.6	1	1	100	1	NA
Pavlov. Cond. index score	62.2	1	1	100	1	NA
Intermittent access intake day 1-15 change	61.5	1	1	100	1	NA
Tibialis anterior weight	59.9	1	1	100	1	NA
Tail length	58.1	1	1	100	1	NA
Reaction time mean AUC	58.0	1	1	100	1	NA
Bone: minimum diameter	57.3	1	1	100	1	NA
Reaction time num false alarms	56.4	1	1	100	1	NA
Pavlov. Cond. magazine entry latency	56.4	1	1	100	1	NA
Pavlov. Cond. lever-magazine prob. diff.	55.1	1	1	100	1	NA
Mean time between licks in bursts	54.9	1	1	100	1	NA
Light reinforcement 1	54.8	1	1	100	1	NA
Median of all reaction times	51.2	1	1	100	1	NA
Pavlov. Cond. lever-magazine prob. diff.	50.5	1	1	100	1	NA
Time in closed arm before self-admin	50.0	1	1	100	1	NA
Se content in liver	47.0	1	1	100	1	NA
Delay discounting water rate 6 sec	44.2	1	1	100	1	NA
Bone: trabecular tissue density	43.1	1	1	100	1	NA
Stereotopy head waving bouts, day 7	42.6	1	1	100	1	NA
Indifference point AUC	42.1	1	1	100	1	NA
Bone: maximum force	42.0	1	1	100	1	NA
Right kidney weight	41.9	1	1	100	1	NA
Reaction time mean	41.3	1	1	100	1	NA
Condit. Reinf. active-inactive response ratio	40.7	1	1	100	1	NA
Bone: final force	39.5	1	1	100	1	NA
Bone: trabecular number	39.4	1	1	100	1	NA
Progressive ratio test 2 breakpoint	38.7	1	1	100	1	NA
Left kidney weight	37.5	1	1	100	1	NA
Pavlov. Cond. lever latency	36.3	1	1	100	1	NA
Pavlov. Cond. magazine entry number	34.9	1	1	100	1	NA
Reaction time premature initiations	34.3	1	1	100	1	NA
Time in novel zone, hab. session 2	34.1	1	1	100	1	NA
Intermittent access day 1 total infusions	32.7	1	1	100	1	NA
Bone volume	32.3	1	1	100	1	NA
Reaction time premature initiation rate	32.1	1	1	100	1	NA
Bone: final moment	31.9	1	1	100	1	NA
Pavlov. Cond. response bias	30.8	1	1	100	1	NA
Saline control response	30.3	1	1	100	1	NA
Bone: maximum moment	29.5	1	1	100	1	NA
Condit. Reinf. active minus inactive responses	29.4	1	1	100	1	NA
Pavlov. Cond. response bias	29.4	1	1	100	1	NA
Pavlov. Cond. index score	28.9	1	1	100	1	NA
Bone surface	28.9	1	1	100	1	NA
Delay discounting total patch changes 24 sec	28.3	1	1	100	1	NA
Compulsive drug intake	28.2	1	1	100	1	NA
Time in familiar zone, hab. session 2	28.0	1	1	100	1	NA
Delay discounting water rate 12 sec	26.1	1	1	100	1	NA
Zn content in liver	25.9	1	1	100	1	NA
Extensor digitorum longus weight	25.8	1	1	100	1	NA
Time in closed arm after self-admin	25.8	1	1	100	1	NA
Stereotopy head waving duration, day 3	25.6	1	1	100	1	NA
Run reversals in cocaine runway, males	25.4	1	1	100	1	NA
Intermittent access intake escalation 2	24.7	1	1	100	1	NA
Liver weight, left	23.6	1	1	100	1	NA
Delta time in open arm before/after self-admin	23.6	1	1	100	1	NA
Pavlov. Cond. change in total contacts	23.1	1	1	100	1	NA
Degree of sensitization stereotypy	22.9	1	1	100	1	NA
Locomotion distance, session 7	21.3	1	1	100	1	NA
Condit. Reinf. inactive responses	20.6	1	0	0	1	NA
Condit. Reinf. lever presses	20.3	1	1	100	1	NA
Delta time to tail flick, test, before/after SA	20.0	1	0	0	1	NA
Time >=10cm from walls, locomotor time 1	19.5	1	0	0	1	NA
Intermitt. access day 1 inactive lever presses	19.4	1	1	100	1	NA
Time >=10cm from walls, locomotor time 2	19.4	1	1	100	1	NA
Intraocular pressure	19.0	1	1	100	1	NA
Indifference point 0 sec	18.7	1	1	100	1	NA
Bone: apparent density	18.6	1	1	100	1	NA
Rb content in liver	18.6	1	1	100	1	NA
Intermittent access day 1 locomotion	18.4	1	1	100	1	NA
Time in open arm after self-admin	18.4	1	1	100	1	NA
Bone: cortical thickness	17.9	1	0	0	1	NA
Delay discounting total patch changes 0 sec	17.7	1	1	100	1	NA
Food consumed during 24 hour testing period	17.5	1	0	0	1	NA
Std. dev. reaction times	17.4	1	1	100	1	NA
Cocaine response before conditioning	17.4	1	1	100	1	NA
Bone: elastic displacement	17.3	1	1	100	1	NA
Pavlov. Cond. lever contacts	17.2	1	1	100	1	NA
Condit. Reinf. inactive responses	17.2	1	0	0	1	NA
Locomotor testing rearing	16.8	1	1	100	1	NA
Weight adjusted by age	16.7	1	1	100	1	NA
Pavlov. Cond. latency score	16.6	1	0	0	1	NA
Time in familiar zone, hab. session 1	16.4	1	0	0	1	NA
Reaction time trials AUC	15.6	1	0	0	1	NA
Incentive salience index mean	15.6	1	0	0	1	NA
Parametrial fat weight	14.9	1	1	100	1	NA
Short access day 10 total infusions	14.4	1	1	100	1	NA
Soleus weight	13.7	1	1	100	1	NA
Post-drug Anxiety	13.7	1	0	0	1	NA
Pavlov. Cond. lever contacts	13.3	1	0	0	1	NA
Conditioned reinforcement - actives	13.0	1	0	0	1	NA
Time in novel zone, hab. session 1	12.9	1	0	0	1	NA
Bone: endosteal estimation	12.7	1	1	100	1	NA
Progressive ratio test 2 active lever presses	12.2	1	0	0	1	NA
Condit. Reinf. active responses	12.2	1	0	0	1	NA
Extinction: sum of active levers before priming	12.2	1	0	0	1	NA
Progressive ratio test 1 active lever presses	11.8	1	0	0	1	NA
Fecal boli incidents, locomotor time 1	11.8	1	0	0	1	NA
Latency to leave start box in cocaine runway	11.8	1	0	0	1	NA
Locomotor testing distance	11.5	1	0	0	1	NA
Heart weight	11.4	1	0	0	1	NA
Short access day 1 locomotion	11.4	1	0	0	1	NA
Progressive ratio test 1 inactive lever presses	10.8	1	0	0	1	NA
Bone: marrow area	10.6	1	1	100	1	NA
Delay discounting water rate 18 sec	10.5	1	0	0	1	NA
Progressive ratio test 1 breakpoint	10.4	1	0	0	1	NA
One hour access (0.3 mA shock)	10.4	1	0	0	1	NA
Bone: trabecular thickness	10.4	1	0	0	1	NA
Reaction time trials on left	10.3	1	0	0	1	NA
Reaction time trials completed	10.3	1	0	0	1	NA
Fe content in liver	10.3	1	0	0	1	NA
Locomotion in novel chamber	10.2	1	0	0	1	NA
Conditioned locomotion	9.9	1	0	0	1	NA
Distance traveled before self-admin	9.8	1	0	0	1	NA
Liver weight, right	9.6	1	0	0	1	NA
Reaction time number correct	9.4	1	0	0	1	NA
Reaction time trials correct on left	9.4	1	0	0	1	NA
Distance moved, locomotor task time 2	9.3	1	0	0	1	NA
Intermitt. access escalation Index	9.2	1	0	0	1	NA
Active lever presses in extinction session 6	9.2	1	0	0	1	NA
Short access day 10 total inactive lever presses	9.1	1	0	0	1	NA
Stereotopy head waving bouts, day 3	8.8	1	0	0	1	NA
Bone: cortical thickness	8.8	1	0	0	1	NA
Change in fecal boli incidents, locomotor task	8.8	1	0	0	1	NA
Delta distance traveled before/after self-admin	8.7	1	0	0	1	NA
Pavlov. Cond. lever latency	8.6	1	0	0	1	NA
Bone: connectivity density	8.5	1	0	0	1	NA
Delay discounting water rate 0 sec	8.1	1	0	0	1	NA
Social time	7.8	1	0	0	1	NA
Bone: periosteal estimation	7.8	1	0	0	1	NA
Body weight	7.7	1	1	100	1	NA
Delta time to tail flick, vehicle, before/after SA	7.5	1	0	0	1	NA
Condit. Reinf. active responses	7.4	1	0	0	1	NA
Rest time, locomotor task time 2	7.0	1	0	0	1	NA
Bone: periosteal perimeter	6.4	1	0	0	1	NA
Total resting periods, locomotor time 2	6.0	1	0	0	1	NA
Water consumed over 24 hours	5.7	1	0	0	1	NA
Bone: trabecular spacing	5.7	1	0	0	1	NA
Ambulatory time before self-admin	5.7	1	0	0	1	NA
Condit. Reinf. active minus inactive responses	5.6	1	0	0	1	NA
Latency to leave start box in cocaine runway, M	5.6	1	0	0	1	NA
Sr content in liver	5.6	1	0	0	1	NA
Tibia length	5.3	1	0	0	1	NA
Seeking ratio, delayed vs. immediate footshock	5.3	1	0	0	1	NA
Glucose	5.0	1	0	0	1	NA
Delta ambulatory time before/after self-admin	4.7	1	0	0	1	NA
Indifference point function ln k	4.4	1	0	0	1	NA
Indifference point function log k	4.4	1	0	0	1	NA
Length with tail	3.2	1	0	0	1	NA
Retroperitoneal fat weight	3.0	1	0	0	1	NA

chisq ratio: Average Chi² statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes⁺: Shared significant genes at Bonferroni correction. # genes⁺⁺: Shared significant genes at transcriptome-wide significance. % genes⁺⁺: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue	modality	# hits	% hits/tests	avg chisq
Liver	alternative polyA	0	0.00	1.27
OFC	isoform ratio	0	0.00	1.25
LHb	alternative polyA	0	0.00	1.24
LHb	mRNA stability	0	0.00	1.23
NAcc	isoform ratio	0	0.00	1.23
IL	isoform ratio	0	0.00	1.22
Adipose	intron excision ratio	0	0.00	1.21
BLA	alternative polyA	0	0.00	1.21
Adipose	alternative polyA	0	0.00	1.19
Liver	mRNA stability	0	0.00	1.19
Eye	mRNA stability	0	0.00	1.18
LHb	isoform ratio	0	0.00	1.18
Liver	gene expression	0	0.00	1.18
Liver	isoform ratio	0	0.00	1.18
OFC	mRNA stability	0	0.00	1.18
PL	isoform ratio	2	0.09	1.18
Adipose	alternative TSS	0	0.00	1.17
Adipose	mRNA stability	0	0.00	1.17
IL	mRNA stability	0	0.00	1.17
NAcc	alternative polyA	0	0.00	1.17
Adipose	gene expression	0	0.00	1.16
BLA	mRNA stability	0	0.00	1.16
Brain	intron excision ratio	0	0.00	1.16
LHb	gene expression	0	0.00	1.16
Liver	alternative TSS	0	0.00	1.16
NAcc	gene expression	0	0.00	1.16
PL	mRNA stability	0	0.00	1.16
BLA	isoform ratio	0	0.00	1.15
Brain	isoform ratio	0	0.00	1.15
IL	gene expression	0	0.00	1.15
PL	alternative polyA	0	0.00	1.15
BLA	gene expression	0	0.00	1.14
Brain	gene expression	0	0.00	1.14
Liver	intron excision ratio	0	0.00	1.14
NAcc	mRNA stability	0	0.00	1.14
OFC	alternative polyA	0	0.00	1.14
BLA	intron excision ratio	0	0.00	1.13
LHb	alternative TSS	0	0.00	1.13
OFC	gene expression	0	0.00	1.13
PL	gene expression	0	0.00	1.13
Adipose	isoform ratio	0	0.00	1.12
Brain	mRNA stability	0	0.00	1.12
PL	intron excision ratio	0	0.00	1.12
Brain	alternative polyA	0	0.00	1.10
Eye	alternative polyA	0	0.00	1.10
IL	alternative polyA	0	0.00	1.10
IL	intron excision ratio	0	0.00	1.10
PL	alternative TSS	0	0.00	1.10
OFC	intron excision ratio	0	0.00	1.09
BLA	alternative TSS	0	0.00	1.06
Eye	gene expression	0	0.00	1.04
NAcc	intron excision ratio	0	0.00	1.03
Brain	alternative TSS	0	0.00	1.02
OFC	alternative TSS	0	0.00	1.02
NAcc	alternative TSS	0	0.00	0.99
IL	alternative TSS	0	0.00	0.96
LHb	intron excision ratio	0	0.00	0.96
Eye	intron excision ratio	0	0.00	0.95
Eye	alternative TSS	0	0.00	0.92
Eye	isoform ratio	0	0.00	0.92

avg chisq: Average Chi² (squared Z-score) across all models in this panel for this trait.