Hub : Genes

Map4k2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000021061 0.48 0.12 0.0e+00 0.34 0.34 0.34 0.34 1.1e-38 2.5e-38 6.3e-39 1.2e-39
2 BLA gene expression ENSRNOG00000021061 0.37 0.12 2.0e-11 0.19 0.19 0.18 0.17 2.4e-10 2.5e-10 5.6e-10 1.3e-09
3 Brain gene expression ENSRNOG00000021061 0.4 0.12 0.0e+00 0.26 0.31 0.29 0.31 1.3e-23 2.3e-29 2.5e-27 3.9e-29
4 LHb gene expression ENSRNOG00000021061 0.22 0.13 6.5e-03 0.1 0.02 0.05 0.08 2.1e-03 8.9e-02 2.1e-02 5.9e-03
5 Liver gene expression ENSRNOG00000021061 0.25 0.14 5.9e-10 0.06 0.07 0.07 0.08 3.3e-07 5.3e-08 2.8e-08 3.4e-09
6 NAcc gene expression ENSRNOG00000021061 0.24 0.1 2.0e-11 0.12 0.14 0.14 0.12 2.9e-09 2.8e-10 1.9e-10 6.4e-09
7 OFC gene expression ENSRNOG00000021061 0.34 0.16 1.8e-04 0.1 0.21 0.16 0.2 2.3e-03 1.0e-05 1.1e-04 2.0e-05
8 PL gene expression ENSRNOG00000021061 0.19 0.08 1.9e-09 0.12 0.12 0.12 0.11 2.2e-09 2.6e-09 3.7e-09 7.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
BMI with tail0.30.85.1-2.2-0.0-0.7-0.10.2-0.8-0.6-0.1
BMI without tail0.30.62.4-1.60.70.50.60.70.40.30.6
Body weight0.52.213.1-3.6-0.2-1.1-0.3-0.4-1.2-1.4-0.3
Epididymis fat weight0.51.28.42.9-0.40.1-0.4-0.10.40.4-0.4
Glucose0.40.63.71.9-0.00.3-0.00.30.50.7-0.0
Heart weight1.82.65.42.31.21.61.21.41.71.91.2
Left kidney weight0.20.72.01.4-0.9-0.4-0.9-0.8-0.3-0.3-0.9
Right kidney weight0.92.63.30.7-1.8-1.6-1.8-1.8-1.5-1.6-1.8
Tail length0.20.62.9-1.70.70.40.70.30.3-0.10.7
Length with tail0.31.27.1-2.7-0.2-0.8-0.2-0.5-0.7-1.2-0.2
Length without tail0.40.93.3-1.8-0.4-1.1-0.4-0.5-1.0-1.1-0.4
Liver weight, left0.00.00.20.5-0.10.1-0.0-0.00.20.00.0
Liver weight, right0.61.01.50.51.00.91.01.11.20.91.0
Parametrial fat weight0.40.85.22.3-0.50.3-0.4-0.10.50.5-0.4
Retroperitoneal fat weight1.13.523.54.8-0.00.9-0.10.51.31.4-0.1
Intraocular pressure1.82.53.50.6-1.8-1.5-1.8-1.9-1.4-1.4-1.8
Extensor digitorum longus weight1.55.832.4-5.7-0.6-1.8-0.6-1.0-2.0-2.2-0.6
Soleus weight1.03.013.23.60.61.40.60.91.81.80.6
Tibialis anterior weight2.89.741.3-6.4-1.3-2.8-1.3-1.9-2.9-3.3-1.3
Tibia length3.59.812.8-1.6-3.1-3.5-3.1-3.3-3.3-3.6-3.1
Number of licking bursts0.30.30.4-0.5-0.5-0.6-0.5-0.5-0.6-0.6-0.5
Food consumed during 24 hour testing period0.80.91.2-0.2-1.0-1.0-1.0-1.1-1.0-1.1-1.0
Times rat made contact with spout0.30.40.6-0.80.60.60.60.60.40.50.6
Mean time between licks in bursts1.92.73.5-0.81.91.61.91.71.61.51.9
Mean num. licks in bursts0.60.71.00.30.81.00.80.80.90.90.8
Std. dev. time between licks in bursts2.83.33.90.32.01.92.01.91.91.92.0
Water consumed over 24 hours0.20.21.3-1.10.10.10.1-0.0-0.2-0.20.1
Indifference point 0 sec0.00.00.00.2-0.1-0.0-0.1-0.1-0.00.1-0.1
Indifference point AUC2.52.94.4-2.1-1.4-1.7-1.4-1.7-1.9-2.1-1.4
Indifference point function ln k6.49.112.23.42.53.12.52.93.43.52.5
Indifference point function log k6.49.112.23.42.53.12.52.93.43.52.5
Delay discounting total patch changes 0 sec0.10.10.20.10.40.40.40.30.40.40.4
Delay discounting total patch changes 12 sec1.41.96.2-2.5-0.8-1.2-0.8-1.1-1.5-1.5-0.8
Delay discounting total patch changes 18 sec0.70.91.2-0.9-0.9-1.0-0.9-0.9-1.1-1.1-0.9
Delay discounting total patch changes 24 sec0.81.04.1-2.0-0.5-0.8-0.5-0.7-1.0-1.1-0.5
Delay discounting total patch changes 6 sec0.10.21.0-1.00.30.10.30.20.0-0.00.3
Delay discounting time to switch 0 sec1.11.62.2-1.0-1.2-1.4-1.2-1.2-1.5-1.4-1.2
Delay discounting water rate 0 sec0.81.33.61.90.81.20.80.81.31.30.8
Delay discounting water rate 12 sec5.17.69.92.92.42.92.42.53.13.12.4
Delay discounting water rate 18 sec3.24.25.51.71.92.11.92.12.32.41.9
Delay discounting water rate 24 sec1.92.63.41.81.41.71.41.51.91.81.4
Delay discounting water rate 6 sec3.95.77.31.72.32.52.32.42.72.72.3
Locomotor activity2.43.84.91.51.92.11.91.92.22.11.9
Locomotor testing distance4.47.49.31.82.72.92.72.73.02.92.7
Locomotor testing rearing2.94.55.71.72.12.32.02.12.42.32.1
Light reinforcement 10.10.10.20.50.30.40.30.20.40.30.3
Light reinforcement 21.92.53.21.2-1.8-1.7-1.8-1.7-1.3-1.4-1.8
Reaction time number correct0.10.10.7-0.80.1-0.20.1-0.0-0.1-0.20.1
Reaction time mean minus median3.74.96.3-2.1-2.1-2.3-2.0-2.1-2.5-2.5-2.1
Reaction time mean minus median AUC1.92.43.1-1.6-1.4-1.6-1.4-1.5-1.8-1.7-1.4
Reaction time num false alarms3.34.65.40.52.32.32.32.32.32.32.2
Reaction time num false alarms AUC2.63.64.4-0.12.12.02.12.11.92.02.1
Reaction time trials correct on left0.10.10.7-0.80.1-0.20.1-0.0-0.1-0.20.1
Reaction time trials on left0.10.10.9-0.90.1-0.20.1-0.1-0.2-0.30.1
Reaction time mean1.21.72.1-0.3-1.4-1.3-1.4-1.4-1.4-1.3-1.4
Reaction time mean AUC1.41.82.3-0.3-1.5-1.3-1.5-1.4-1.5-1.3-1.5
Median of all reaction times0.70.91.30.1-1.1-0.9-1.1-1.0-1.0-0.8-1.1
Reaction time omissions0.60.83.2-1.8-0.6-0.8-0.6-0.6-0.9-0.7-0.6
Reaction time false alarm rate2.43.34.00.71.92.01.92.02.02.01.9
Reaction time premature initiation rate1.92.55.0-2.21.71.31.81.51.11.01.7
Reaction time premature initiations1.62.38.3-2.91.50.91.51.20.70.61.5
Std. dev. reaction times1.92.73.4-1.2-1.7-1.7-1.6-1.6-1.8-1.7-1.6
Reaction time trials completed0.10.10.9-0.90.1-0.20.1-0.1-0.2-0.30.1
Reaction time trials AUC0.10.10.4-0.70.3-0.00.30.20.1-0.00.3
Social response proportion0.70.81.1-0.8-0.8-0.9-0.8-0.9-1.0-1.1-0.8
Social responses0.00.00.1-0.30.0-0.10.0-0.1-0.1-0.30.0
Social time0.10.10.3-0.50.30.00.30.10.1-0.00.3
Conditioned locomotion0.30.32.4-1.60.1-0.30.1-0.0-0.3-0.30.1
Cocaine response after cond. corrected2.22.53.21.31.51.71.51.61.81.81.5
Cocaine response after cond. not corrected1.71.92.41.11.31.51.31.41.51.51.3
Cocaine response before conditioning1.01.21.6-1.1-1.0-1.1-1.0-1.0-1.2-1.2-1.0
Saline control response0.60.85.5-2.40.4-0.10.40.3-0.2-0.40.4
Condit. Reinf. active minus inactive responses0.70.91.20.0-1.1-1.0-1.1-1.0-1.0-0.9-1.1
Condit. Reinf. active-inactive response ratio1.92.02.70.5-1.6-1.5-1.6-1.4-1.3-1.2-1.6
Condit. Reinf. active responses0.30.40.6-0.3-0.7-0.6-0.7-0.6-0.7-0.6-0.7
Condit. Reinf. inactive responses0.40.50.7-0.40.70.80.70.70.50.60.7
Condit. Reinf. lever presses2.73.74.9-1.7-1.8-2.1-1.8-1.9-2.1-2.2-1.8
Condit. Reinf. lever reinforcers received0.70.91.2-0.8-1.0-1.0-1.0-0.9-1.1-1.0-1.0
Pavlov. Cond. lever latency1.21.62.10.61.21.51.21.31.31.51.2
Pavlov. Cond. magazine entry latency1.11.33.7-1.9-0.8-1.0-0.8-0.9-1.3-1.3-0.8
Pavlov. Cond. change in total contacts4.56.37.8-1.6-2.5-2.7-2.5-2.6-2.8-2.7-2.5
Pavlov. Cond. index score2.63.44.4-1.6-1.7-2.0-1.7-1.8-2.0-2.1-1.7
Pavlov. Cond. latency score2.32.93.8-1.3-1.6-1.9-1.6-1.7-1.9-1.9-1.6
Pavlov. Cond. lever contacts1.21.72.4-0.6-1.3-1.5-1.3-1.4-1.4-1.5-1.3
Pavlov. Cond. magazine entry number3.34.17.82.81.62.01.61.82.22.31.6
Pavlov. Cond. intertrial magazine entries0.20.31.51.20.10.30.10.20.40.40.1
Pavlov. Cond. lever-magazine prob. diff.2.53.34.3-1.8-1.6-1.9-1.6-1.7-2.0-2.1-1.6
Pavlov. Cond. response bias2.02.83.8-1.5-1.5-1.8-1.5-1.7-1.8-2.0-1.5
Conditioned reinforcement - actives2.42.33.00.3-1.7-1.6-1.7-1.7-1.5-1.4-1.7
Conditioned reinforcement - inactives2.02.36.52.6-1.6-0.8-1.6-1.4-0.8-0.6-1.6
Conditioned locomotion1.01.28.52.9-0.5-0.1-0.7-0.30.20.3-0.7
Intermittent access intake day 1-15 change1.41.41.80.4-1.3-1.1-1.3-1.3-1.1-1.1-1.3
Intermittent access intake escalation1.11.11.40.4-1.2-0.9-1.2-1.2-1.0-0.9-1.2
Intermittent access intake escalation 21.71.62.4-0.2-1.5-1.2-1.4-1.5-1.3-1.2-1.4
Intermitt. access day 1 inactive lever presses0.60.74.42.1-0.60.0-0.4-0.50.10.2-0.4
Intermitt. access day 15 inactive lever presses1.71.94.92.2-1.4-1.0-1.5-1.3-0.8-0.7-1.5
Intermitt. access escalation Index3.63.24.02.01.61.81.51.91.92.01.5
Intermittent access day 1 total infusions1.01.28.42.9-0.10.1-0.40.30.40.6-0.4
Intermittent access day 15 total infusions1.82.09.13.0-1.2-0.7-1.4-0.8-0.5-0.3-1.4
Intermittent access terminal intake (last 3 days)2.32.56.82.6-1.5-1.2-1.8-1.2-1.0-0.8-1.8
Intermittent access total infusions1.31.55.92.4-1.0-0.8-1.3-0.7-0.5-0.3-1.3
Intermittent access day 1 locomotion1.71.75.82.41.01.00.71.31.31.40.7
Intermittent access day 15 total locomotion1.21.34.62.1-0.9-0.6-1.3-0.7-0.6-0.4-1.3
Intermittent access total locomotion1.51.78.02.8-1.0-0.7-1.4-0.6-0.5-0.2-1.4
Intermittent access standard deviation0.70.81.31.1-1.0-0.7-1.0-1.0-0.6-0.6-1.0
Cocaine induced anxiety0.80.91.0-0.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0
Post-drug Anxiety2.73.04.4-1.2-2.0-1.8-1.5-2.1-1.8-1.8-1.5
Baseline Anxiety0.30.32.3-1.5-0.1-0.20.3-0.3-0.2-0.30.3
Lifetime Intake0.80.85.22.3-0.5-0.3-0.7-0.2-0.00.2-0.7
Incentive Sensitization - Responses1.01.01.40.7-1.2-0.9-1.1-1.1-0.9-0.7-1.1
Incentive Sensitization - Breakpoint1.01.01.40.8-1.2-0.9-1.2-1.1-0.9-0.7-1.2
Progressive ratio test 1 active lever presses0.50.53.41.9-0.3-0.1-0.5-0.20.00.2-0.5
Progressive ratio test 1 breakpoint0.40.53.01.7-0.2-0.1-0.5-0.20.00.1-0.5
Progressive ratio test 1 inactive lever presses0.50.52.01.40.30.70.40.40.80.90.4
Progressive ratio test 2 active lever presses1.61.74.62.1-1.4-0.8-1.4-1.2-0.7-0.5-1.4
Progressive ratio test 2 breakpoint1.21.35.92.4-1.0-0.5-1.1-0.8-0.3-0.2-1.1
Progressive ratio test 2 inactive lever presses2.22.611.33.4-1.6-0.7-1.5-1.2-0.5-0.2-1.5
Total sessions with >9 infusions0.91.02.51.60.70.80.70.91.11.20.7
Short access day 1 total inactive lever presses1.01.14.12.00.50.90.50.71.01.30.5
Short access day 10 total inactive lever presses3.13.55.12.31.51.91.61.72.12.11.6
Short access day 1 total infusions0.70.83.51.90.20.60.30.60.81.10.3
Short access day 10 total infusions0.30.42.41.5-0.10.1-0.20.20.30.5-0.2
Short access total infusions0.50.51.81.40.40.50.30.60.70.90.3
Short access day 1 locomotion0.90.92.01.40.60.90.60.91.11.20.6
Short access day 10 total locomotion0.60.72.21.50.70.60.31.00.70.90.3
Short access total locomotion0.90.91.61.30.80.80.61.11.01.10.6
Compulsive drug intake2.62.63.7-1.41.91.51.91.61.31.11.9
One hour access (0.3 mA shock)1.51.811.83.4-0.7-0.1-0.9-0.40.10.3-0.9
One hour access (shock baseline)3.74.38.52.9-2.3-1.6-2.4-2.0-1.4-1.1-2.4
Number of responses in last shaping day0.80.91.30.80.71.00.90.81.11.10.9
Context. condit. distance diff. score1.11.43.21.80.91.20.91.01.31.20.9
Locomotion velocity, session 10.80.81.1-0.31.00.91.01.00.90.81.0
Locomotion distance, session 10.40.50.7-0.60.70.60.70.80.60.60.7
Locomotion velocity, session 20.30.42.5-1.60.0-0.40.0-0.0-0.4-0.40.0
Locomotion distance, session 20.40.60.8-0.70.80.60.80.90.60.70.8
Locomotion velocity, session 30.50.60.80.60.70.70.70.80.80.90.7
Locomotion distance, session 30.10.10.10.30.30.40.30.40.40.30.3
Stereotopy head waving bouts, day 31.01.21.80.91.01.01.01.21.21.31.0
Stereotopy head waving duration, day 30.30.30.80.90.40.50.40.50.60.80.4
Locomotion velocity, session 70.20.20.80.90.20.40.20.50.50.70.2
Locomotion distance, session 71.11.42.00.41.21.31.21.31.31.41.2
Stereotopy head waving bouts, day 70.80.91.20.3-1.1-1.0-1.1-1.0-0.9-0.9-1.1
Stereotopy head waving duration, day 71.31.62.0-1.0-1.2-1.3-1.2-1.2-1.4-1.4-1.2
Locomotion velocity, session 80.60.71.1-0.71.00.71.00.90.80.51.0
Locomotion distance, session 80.20.30.60.80.40.40.40.60.60.60.4
Degree of sensitization distance0.40.40.60.30.60.60.60.70.70.80.6
Degree of sensitization stereotypy2.02.12.5-0.7-1.5-1.6-1.5-1.5-1.6-1.6-1.5
Condit. Reinf. active minus inactive responses0.10.10.4-0.60.20.30.20.30.10.30.2
Condit. Reinf. active-inactive response ratio0.00.00.2-0.40.10.20.10.0-0.00.10.1
Condit. Reinf. active responses0.00.00.0-0.2-0.1-0.1-0.1-0.0-0.20.0-0.1
Condit. Reinf. inactive responses0.10.20.30.5-0.4-0.5-0.4-0.3-0.3-0.2-0.4
Incentive salience index mean0.10.10.5-0.70.20.10.20.30.00.20.2
Condit. Reinf. lever presses0.20.30.4-0.6-0.4-0.6-0.4-0.4-0.6-0.5-0.4
Time in familiar zone, hab. session 10.10.10.50.70.10.20.10.20.20.30.1
Time in novel zone, hab. session 11.01.01.20.21.11.11.11.01.11.01.1
Total zone transitions, hab. session 10.20.31.4-1.2-0.2-0.4-0.2-0.3-0.5-0.4-0.2
Total locomotion distance, hab. session 10.00.10.30.50.00.10.00.20.20.30.0
Locomotion velocity, hab. session 10.00.00.00.0-0.1-0.1-0.10.0-0.00.1-0.1
Time in familiar zone, hab. session 22.02.12.60.31.61.51.61.61.61.41.6
Time in novel zone, hab. session 20.60.60.8-0.5-0.8-0.7-0.8-0.8-0.9-0.7-0.8
Total zone transitions, hab. session 20.20.21.5-1.20.2-0.00.20.3-0.10.10.2
Total locomotion distance, hab. session 20.30.40.70.20.60.60.60.80.60.90.6
Locomotion velocity, hab. session 20.10.10.30.40.20.20.20.50.30.60.2
Novel to familiar place preference ratio3.63.84.8-1.2-2.0-2.0-2.0-2.0-2.2-2.2-2.0
Novelty place preference2.72.83.5-0.8-1.7-1.7-1.7-1.7-1.9-1.8-1.7
Time in novel zone, NPP test1.81.92.4-0.6-1.4-1.4-1.4-1.4-1.6-1.5-1.4
Total zone transitions, NPP test0.50.73.3-1.8-0.3-0.7-0.3-0.4-0.8-0.7-0.3
Total locomotion distance, NPP test0.10.10.2-0.10.40.30.40.50.30.50.4
Locomotion velocity, NPP test0.00.00.1-0.20.10.10.10.20.10.30.1
Pavlov. Cond. lever latency0.10.10.30.60.30.40.30.20.40.40.3
Pavlov. Cond. magazine entry latency0.30.40.5-0.6-0.6-0.5-0.6-0.5-0.7-0.6-0.6
Pavlov. Cond. change in total contacts1.71.82.2-0.4-1.5-1.3-1.5-1.4-1.5-1.3-1.5
Pavlov. Cond. index score0.40.50.7-0.6-0.7-0.7-0.7-0.7-0.8-0.8-0.7
Pavlov. Cond. latency score0.10.10.2-0.3-0.4-0.4-0.4-0.3-0.5-0.4-0.4
Pavlov. Cond. lever contacts0.00.00.0-0.20.10.10.10.20.00.10.1
Pavlov. Cond. magazine entry number1.21.41.80.81.21.21.21.31.41.31.2
Pavlov. Cond. intertrial magazine entries0.20.20.40.6-0.5-0.3-0.5-0.5-0.3-0.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.50.60.9-0.8-0.8-0.8-0.8-0.7-0.9-0.9-0.8
Pavlov. Cond. response bias0.50.60.8-0.6-0.8-0.7-0.8-0.8-0.9-0.8-0.8
Bone: apparent density0.20.30.30.1-0.5-0.6-0.5-0.5-0.5-0.6-0.5
Bone surface3.56.18.2-2.2-2.2-2.8-2.2-2.4-2.7-2.9-2.2
Bone volume2.74.55.7-0.9-2.2-2.4-2.2-2.2-2.3-2.4-2.2
Bone: connectivity density0.60.91.4-1.1-0.7-1.1-0.7-0.8-1.1-1.2-0.7
Bone: cortical apparent density0.10.20.9-1.00.20.30.20.2-0.00.20.2
Bone: cortical area0.91.31.9-0.7-1.1-1.4-1.1-1.2-1.2-1.4-1.1
Bone: cortical porosity0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.10.0-0.1
Bone: cortical porosity0.10.10.4-0.6-0.0-0.2-0.0-0.1-0.2-0.1-0.0
Bone: cortical thickness0.40.64.0-2.00.3-0.10.30.0-0.3-0.40.3
Bone: cortical thickness1.11.31.8-0.81.31.21.31.11.00.91.3
Bone: cortical tissue density0.20.21.2-1.10.30.30.30.2-0.00.20.3
Bone: elastic displacement2.42.83.50.91.71.81.71.71.91.81.7
Bone: elastic work1.41.82.4-0.91.61.31.61.41.21.11.6
Bone: endosteal estimation0.30.63.21.8-0.6-0.6-0.6-0.3-0.1-0.1-0.6
Bone: endosteal perimeter1.12.33.82.0-1.7-1.5-1.7-1.4-1.1-1.1-1.7
Bone: final force1.01.73.7-1.9-0.9-1.4-0.9-1.0-1.4-1.5-0.9
Bone: final moment0.91.53.0-1.7-0.9-1.4-0.9-1.0-1.3-1.4-0.9
Bone: marrow area0.30.53.31.8-0.5-0.4-0.5-0.20.00.0-0.5
Bone: maximum diameter1.83.44.7-0.2-1.9-2.2-1.9-1.9-1.9-2.1-1.9
Bone: maximum force1.93.34.3-2.0-1.6-2.1-1.6-1.6-2.0-2.1-1.6
Bone: maximum moment1.52.63.5-1.7-1.4-1.9-1.4-1.4-1.8-1.9-1.4
Bone: minimum diameter0.30.52.61.6-0.6-0.3-0.6-0.3-0.1-0.0-0.6
Bone: periosteal estimation0.71.52.20.6-1.3-1.5-1.3-1.2-1.1-1.2-1.3
Bone: periosteal perimeter1.01.62.30.1-1.3-1.5-1.3-1.3-1.3-1.3-1.3
Bone: post-yield work3.75.16.5-0.0-2.5-2.5-2.5-2.2-2.4-2.0-2.5
Bone: stiffness2.33.64.6-1.8-1.8-2.1-1.8-1.8-2.1-2.1-1.8
Bone: tissue strength0.50.50.6-0.1-0.8-0.8-0.8-0.7-0.7-0.6-0.8
Bone: trabecular number1.21.82.2-0.1-1.4-1.5-1.4-1.4-1.4-1.5-1.4
Bone: trabecular spacing1.41.82.30.01.41.51.41.41.41.51.4
Bone: trabecular thickness0.30.31.91.4-0.4-0.2-0.4-0.3-0.1-0.0-0.4
Bone: trabecular tissue density0.60.85.72.4-0.10.4-0.10.10.50.5-0.1
Breakpoint value in progressive ratio session1.82.02.7-1.6-1.2-1.4-1.2-1.4-1.6-1.6-1.2
Distance traveled before self-admin1.61.82.1-0.7-1.3-1.4-1.3-1.4-1.4-1.4-1.3
Distance traveled after self-admin0.70.81.0-0.4-0.9-0.9-0.9-1.0-1.0-0.9-0.9
Delta time in closed arm before/after self-admin4.54.35.5-0.12.32.12.32.32.22.12.3
Delta time in open arm before/after self-admin3.13.03.8-0.1-1.9-1.7-1.9-1.9-1.8-1.9-1.9
Diff in mean of infusions in LGA sessions0.30.30.6-0.8-0.4-0.5-0.4-0.6-0.6-0.6-0.4
Extinction: sum of active levers before priming1.41.43.4-1.8-0.9-1.1-0.9-1.0-1.4-1.3-0.9
Active lever presses in extinction session 63.43.24.7-1.4-1.6-2.0-1.6-1.9-1.9-2.2-1.6
Delta distance traveled before/after self-admin0.60.70.80.20.90.80.90.90.90.80.9
Delta ambulatory time before/after self-admin1.11.21.4-0.01.21.11.21.11.11.11.2
Time in closed arm before self-admin1.31.51.80.2-1.3-1.3-1.3-1.3-1.2-1.3-1.3
Time in closed arm after self-admin1.01.01.30.41.00.91.01.11.11.11.0
Time in open arm before self-admin6.26.67.90.02.82.82.82.82.62.72.8
Time in open arm after self-admin0.10.10.20.00.30.50.30.20.30.30.3
Sum of active levers in priming session hrs 5-67.27.18.4-1.6-2.6-2.9-2.6-2.9-2.9-2.9-2.6
Time to tail flick, vehicle, before self-admin0.50.50.8-0.9-0.6-0.7-0.6-0.5-0.8-0.8-0.6
Time to tail flick, vehicle, after self-admin0.70.81.3-1.11.00.71.01.00.60.41.0
Time to tail flick, test, before self-admin1.61.62.11.11.21.21.21.41.41.51.2
Time to tail flick, test, after self-admin0.10.10.8-0.9-0.0-0.1-0.0-0.0-0.2-0.2-0.0
Delta time to tail flick, vehicle, before/after SA0.60.60.8-0.50.90.80.90.80.70.60.9
Delta time to tail flick, test, before/after SA2.11.94.2-2.1-1.1-1.2-1.1-1.3-1.5-1.5-1.1
Ambulatory time before self-admin3.13.33.8-0.4-1.9-2.0-1.9-1.9-1.9-1.9-1.9
Ambulatory time after self-admin1.11.21.60.4-1.3-1.1-1.3-1.2-1.1-0.9-1.3
Total heroin consumption1.61.98.4-2.9-0.7-1.1-0.7-0.9-1.4-1.3-0.7
Area under the delay curve0.40.40.7-0.10.60.90.60.80.60.70.7
Delay disc. indifference point, 0s delay1.41.52.10.61.11.51.11.31.41.31.4
Delay disc. indifference point, 16s delay0.10.10.70.9-0.20.1-0.2-0.0-0.10.1-0.4
Delay disc. indifference point, 2s delay0.00.00.0-0.00.00.10.00.10.10.10.1
Delay disc. indifference point, 24s delay1.21.11.4-0.21.21.21.21.21.01.11.1
Delay disc. indifference point, 4s delay1.81.92.60.21.41.61.41.51.41.41.5
Delay disc. indifference point, 8s delay1.21.31.80.11.21.31.21.21.21.21.3
Delay discount exponential model param0.40.40.70.2-0.7-0.8-0.7-0.7-0.6-0.7-0.7
Delay discount hyperbolic model param0.40.40.70.3-0.7-0.8-0.7-0.7-0.6-0.7-0.7
Fecal boli incidents, locomotor time 13.43.64.9-0.2-2.2-1.9-2.2-2.2-1.8-2.0-1.8
Change in fecal boli incidents, locomotor task3.73.54.20.62.01.82.02.12.02.02.0
Time >=10cm from walls, locomotor time 11.71.72.31.1-1.4-1.4-1.4-1.2-1.2-1.1-1.5
Bouts of movement, locomotor time 11.21.33.4-1.9-0.9-0.9-0.9-1.1-1.3-1.0-0.9
Total resting periods, locomotor time 11.41.62.7-1.6-1.2-1.1-1.2-1.3-1.4-1.1-1.1
Rest time, locomotor task time 10.20.21.21.1-0.1-0.0-0.1-0.10.30.3-0.0
Distance moved, locomotor task time 10.00.00.0-0.10.20.10.20.20.00.10.1
Vertical activity count, locomotor time 10.40.41.21.10.40.60.40.50.60.60.3
Time >=10cm from walls, locomotor time 21.51.62.1-0.1-1.3-1.4-1.3-1.3-1.4-1.2-1.4
Bouts of movement, locomotor time 20.10.10.6-0.8-0.3-0.1-0.3-0.3-0.4-0.3-0.2
Total resting periods, locomotor time 20.10.10.2-0.4-0.3-0.1-0.3-0.3-0.4-0.2-0.2
Rest time, locomotor task time 20.70.84.72.20.10.50.10.30.80.80.3
Distance moved, locomotor task time 20.40.42.1-1.5-0.2-0.5-0.2-0.3-0.7-0.6-0.3
Vertical activity count, locomotor time 20.80.91.4-0.31.20.91.21.10.90.91.0
Weight adjusted by age1.71.95.0-2.2-1.0-1.3-1.0-1.1-1.5-1.4-1.0
Seeking ratio, delayed vs. immediate footshock0.20.20.50.20.40.60.40.50.40.70.4
Locomotion in novel chamber1.62.06.52.6-1.4-0.9-1.4-1.2-0.7-0.6-1.4
Locomotion in novel chamber post-restriction0.60.85.62.4-0.30.2-0.3-0.10.40.3-0.3
Progressive ratio0.70.81.2-1.1-0.8-1.1-0.8-0.7-1.1-1.0-0.8
Food seeking constrained by brief footshock1.01.21.50.11.21.11.21.21.10.91.2
Seeking ratio, punishment vs. effort3.03.64.71.31.92.21.91.92.12.01.9
Run reversals in cocaine runway, females3.23.24.4-0.42.01.72.02.11.81.82.0
Run reversals in cocaine runway, males0.10.10.30.60.30.30.30.20.40.10.3
Latency to leave start box in cocaine runway0.10.10.40.6-0.2-0.1-0.2-0.1-0.1-0.0-0.2
Latency to leave start box in cocaine runway, F0.10.10.20.0-0.5-0.2-0.5-0.4-0.4-0.3-0.5
Latency to leave start box in cocaine runway, M0.10.10.50.70.10.00.10.20.30.20.1
Cd content in liver1.11.21.51.2-1.2-0.9-1.2-1.2-0.8-1.0-1.2
Co content in liver2.53.04.30.81.72.11.71.71.91.91.7
Cu content in liver0.00.10.1-0.2-0.2-0.1-0.2-0.3-0.3-0.2-0.2
Fe content in liver0.40.40.9-0.5-0.4-0.8-0.4-0.4-1.0-0.9-0.4
K content in liver0.10.10.9-1.0-0.0-0.2-0.00.0-0.2-0.20.0
Mg content in liver0.00.00.1-0.10.10.10.10.30.00.30.1
Mn content in liver2.52.93.8-1.8-1.5-1.9-1.5-1.6-1.9-1.9-1.5
Na content in liver1.01.01.5-1.2-0.9-1.1-0.9-1.0-1.0-1.1-0.8
Rb content in liver0.70.92.61.60.61.00.60.71.01.10.6
Se content in liver2.93.54.60.4-1.9-2.1-1.9-1.8-2.1-2.0-1.9
Sr content in liver1.81.64.2-2.0-0.9-1.2-0.9-1.1-1.3-1.5-0.9
Zn content in liver0.40.41.0-1.0-0.3-0.6-0.3-0.4-0.9-0.7-0.3