Bone: maximum force

Tags: Physiology · Bone

Project: r01_doug_adams

7 loci · 8 genes with independent associations · 51 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr2 175255218 176649376 1 1 7.17e-11 3.51e-01 1.33e-32 Ilf2
2 chr3 44152620 45549784 1 1 1.95e-09 5.92e-03 4.29e-05 Ly75
3 chr7 129232833 131872914 44 2 3.03e-08 1.34e-07 1.00e+00 LOC102546778 Tuba1b
4 chr9 87238851 88635740 1 1 1.67e-07 3.45e-06 8.05e-02 Efhd1
5 chr10 106235924 107195627 1 1 1.18e-07 4.58e-09 1.60e-06 B3gntl1
6 chr16 2113611 4396663 2 1 3.29e-08 7.49e-09 2.74e-54 Erc2
7 chr16 17477182 18874041 1 1 2.26e-07 4.57e-05 3.98e-02 Gtpbp3

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 4.5 23 0 0 1 3.22e-132 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Body weight 5.96 25 5 62.5 1 6.14e-116 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Gtpbp3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Left kidney weight 5.75 1 0 0 0 1.00e+00 B3gntl1
Right kidney weight 4.8 1 0 0 0 1.00e+00 B3gntl1
Length without tail 7.42 24 0 0 1 1.48e-110 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Retroperitoneal fat weight 8.85 1 1 12.5 0 1.00e+00 Ly75
Extensor digitorum longus weight 4.23 22 0 0 1 9.87e-110 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Tibialis anterior weight 3.75 1 0 0 0 1.00e+00 Ly75
Tibia length 6.65 25 1 12.5 1 8.71e-95 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Efhd1 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Food consumed during 24 hour testing period 11.76 1 0 0 0 1.00e+00 Ly75
Water consumed over 24 hours 19.18 1 0 0 0 1.00e+00 Ly75
Patch foraging total patch changes 18 sec 13.09 1 0 0 0 1.00e+00 Ly75
Reaction time mean minus median 9.44 4 0 0 -1 8.36e-09 LOC102546778 Mcrs1 Prph Spats2
Reaction time mean minus median AUC 17.14 1 0 0 0 1.00e+00 Ly75
Reaction time mean 9.87 1 0 0 0 1.00e+00 Ly75
Reaction time mean AUC 10.73 1 0 0 0 1.00e+00 Ly75
Reaction time omissions 10.01 22 0 0 -1 6.19e-136 Aqp5 Asic1 Bcdin3d C1ql4 Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Reaction time premature initiation rate 14.82 2 1 12.5 0 1.00e+00 Ilf2 Ly75
Reaction time premature initiations 12.93 1 0 0 0 1.00e+00 Ilf2
Std. dev. reaction times 14.29 1 0 0 0 1.00e+00 Ly75
Social response proportion 11.26 1 0 0 0 1.00e+00 Ilf2
Condit. Reinf. active minus inactive responses 28.62 1 1 12.5 0 1.00e+00 Ly75
Condit. Reinf. active-inactive response ratio 11.56 1 0 0 0 1.00e+00 Ly75
Condit. Reinf. active responses 24.88 1 1 12.5 0 1.00e+00 Ly75
Condit. Reinf. lever reinforcers received 19.5 1 1 12.5 0 1.00e+00 Ly75
Pavlov. Cond. change in total contacts 11.21 1 0 0 0 1.00e+00 Ly75
Locomotion distance, session 3 14.48 1 0 0 0 1.00e+00 Ly75
Stereotopy head waving bouts, day 7 23.7 1 0 0 0 1.00e+00 Ly75
Stereotopy head waving duration, day 7 21.6 1 0 0 0 1.00e+00 Ly75
Locomotion velocity, session 8 12.76 2 0 0 0 1.00e+00 Ilf2 Wnt5a
Degree of sensitization stereotypy 38.66 1 1 12.5 0 1.00e+00 Ly75
Condit. Reinf. active minus inactive responses 16.76 1 0 0 0 1.00e+00 Ly75
Condit. Reinf. active responses 13.63 1 0 0 0 1.00e+00 Ly75
Incentive salience index mean 15.42 1 0 0 0 1.00e+00 Ly75
Condit. Reinf. lever presses 10.84 1 0 0 0 1.00e+00 Ilf2
Total zone transitions, hab. session 2 19.52 1 0 0 0 1.00e+00 Ly75
Total locomotion distance, hab. session 2 24.97 1 1 12.5 0 1.00e+00 Ly75
Locomotion velocity, hab. session 2 19.99 1 1 12.5 0 1.00e+00 Ly75
Pavlov. Cond. lever latency 21.9 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. magazine entry latency 28.91 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. change in total contacts 18.74 1 0 0 0 1.00e+00 Ilf2
Pavlov. Cond. index score 34.08 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. latency score 30.82 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. lever contacts 37.24 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. magazine entry number 42.75 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. intertrial magazine entries 13.5 1 0 0 0 1.00e+00 Ilf2
Pavlov. Cond. lever-magazine prob. diff. 35.53 1 1 12.5 0 1.00e+00 Ilf2
Pavlov. Cond. response bias 41.38 1 1 12.5 0 1.00e+00 Ilf2
Bone: apparent density 10.64 24 1 12.5 1 3.61e-103 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone surface 12.85 24 1 12.5 1 7.00e-91 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone volume 10.19 24 1 12.5 0.99 8.52e-86 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone: connectivity density 8.46 11 1 12.5 1 1.38e-25 Dnajc22 Kcnh3 LOC102546778 Ly75 Prkag1 Prpf40b Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone: cortical apparent density 18.66 1 0 0 0 1.00e+00 Ly75
Bone: cortical area 9.38 25 1 12.5 1 1.36e-91 Asic1 B3gntl1 Bcdin3d C1ql4 Dnajc22 Erc2 Faim2 Fmnl3 Gtpbp3 Ilf2 Kcnh3 LOC100362820 LOC102546778 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: cortical thickness 20.09 2 1 12.5 0 1.00e+00 B3gntl1 Gtpbp3
Bone: cortical thickness 12.83 1 0 0 0 1.00e+00 B3gntl1
Bone: cortical tissue density 17.88 1 0 0 0 1.00e+00 Ly75
Bone: elastic work 13.74 2 0 0 0 1.00e+00 B3gntl1 Ly75
Bone: endosteal estimation 8.33 27 0 0 1 6.53e-118 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Erc2 Faim2 Fmnl3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: endosteal perimeter 7.03 23 0 0 1 1.73e-136 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone: final force 11.89 30 3 37.5 1 7.29e-106 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Efhd1 Erc2 Faim2 Fmnl3 Gtpbp3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: final moment 13 30 4 50 1 1.42e-97 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Efhd1 Erc2 Faim2 Fmnl3 Gtpbp3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: marrow area 8.07 27 0 0 1 5.31e-118 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Erc2 Faim2 Fmnl3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: maximum moment 17.55 30 28 350 1 2.07e-147 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Efhd1 Erc2 Faim2 Fmnl3 Gtpbp3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: minimum diameter 9.54 27 1 12.5 1 8.81e-115 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Erc2 Faim2 Fmnl3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: periosteal estimation 11.84 27 3 37.5 1 2.34e-115 Aqp5 Asic1 Bcdin3d C1ql4 Dip2b Dnajc22 Erc2 Faim2 Fmnl3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: periosteal perimeter 10.29 27 0 0 1 1.08e-123 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Faim2 Fmnl3 Gtpbp3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: post-yield work 9.78 22 0 0 1 6.32e-163 Aqp5 Asic1 Bcdin3d C1ql4 Dnajc22 Faim2 Fmnl3 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b
Bone: stiffness 18.33 30 22 275 1 6.03e-98 Aqp5 Asic1 B3gntl1 Bcdin3d C1ql4 Dip2b Dnajc22 Efhd1 Erc2 Faim2 Fmnl3 Gtpbp3 Ilf2 Kcnh3 LOC100362820 LOC102546778 LOC108351553 Ly75 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Smarcd1 Spats2 Tmbim6 Tuba1b Tuba1c Wnt10b Wnt5a
Bone: tissue strength 19.03 1 0 0 0 1.00e+00 Efhd1
Bone: trabecular number 12.8 4 1 12.5 0.96 2.42e-03 LOC100362820 Ly75 Prkag1 Tuba1b
Bone: trabecular spacing 60.24 1 1 12.5 0 1.00e+00 Ly75
Bone: trabecular thickness 47.42 1 1 12.5 0 1.00e+00 Ly75
Rest time, locomotor task time 1 12.3 1 0 0 0 1.00e+00 Ly75
Distance moved, locomotor task time 1 13.8 1 0 0 0 1.00e+00 Ly75
Weight adjusted by age 20.87 1 0 0 0 1.00e+00 Ly75
Locomotion in novel chamber 34.01 1 1 12.5 0 1.00e+00 Ly75
Progressive ratio 12.89 1 0 0 0 1.00e+00 Ilf2
Food seeking constrained by brief footshock 13.79 1 0 0 0 1.00e+00 Ly75
Run reversals in cocaine runway, females 21.72 1 0 0 0 1.00e+00 Ly75
Latency to leave start box in cocaine runway, M 14.76 1 0 0 0 1.00e+00 Ilf2
Cd content in liver 13.38 1 0 0 0 1.00e+00 Ilf2
K content in liver 12.92 1 0 0 0 1.00e+00 Ly75
Mg content in liver 13.79 1 0 0 0 1.00e+00 Ly75
Mn content in liver 32.26 1 1 12.5 0 1.00e+00 Ly75
Na content in liver 12.24 1 0 0 0 1.00e+00 Ly75
Sr content in liver 14.16 1 0 0 0 1.00e+00 Ly75
Zn content in liver 12.81 1 0 0 0 1.00e+00 Ly75

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 2 0.1 1.8
Adipose alternative TSS 1 0 1.74
Adipose gene expression 4 0 1.68
Adipose isoform ratio 1 0 1.65
Adipose intron excision ratio 0 0 1.65
Adipose mRNA stability 2 0 1.73
BLA alternative polyA 0 0 1.95
BLA alternative TSS 0 0 1.67
BLA gene expression 4 0.1 1.81
BLA isoform ratio 1 0 1.69
BLA intron excision ratio 0 0 1.66
BLA mRNA stability 1 0 1.76
Brain alternative polyA 0 0 1.8
Brain alternative TSS 0 0 1.68
Brain gene expression 6 0.1 1.69
Brain isoform ratio 3 0.1 1.71
Brain intron excision ratio 1 0 1.65
Brain mRNA stability 2 0 1.7
Eye alternative polyA 0 0 2.12
Eye alternative TSS 0 0 1.44
Eye gene expression 0 0 1.71
Eye isoform ratio 0 0 1.98
Eye intron excision ratio 0 0 1.52
Eye mRNA stability 0 0 1.59
IL alternative polyA 0 0 1.86
IL alternative TSS 0 0 1.7
IL gene expression 2 0 1.81
IL isoform ratio 0 0 1.72
IL intron excision ratio 0 0 1.81
IL mRNA stability 0 0 1.85
LHb alternative polyA 0 0 1.9
LHb alternative TSS 1 0.2 1.67
LHb gene expression 6 0.2 1.77
LHb isoform ratio 0 0 1.63
LHb intron excision ratio 0 0 1.7
LHb mRNA stability 1 0.1 1.69
Liver alternative polyA 0 0 1.72
Liver alternative TSS 0 0 1.7
Liver gene expression 2 0 1.65
Liver isoform ratio 2 0.1 1.65
Liver intron excision ratio 0 0 1.5
Liver mRNA stability 2 0.1 1.63
NAcc alternative polyA 0 0 1.75
NAcc alternative TSS 0 0 1.82
NAcc gene expression 7 0.1 1.74
NAcc isoform ratio 0 0 1.73
NAcc intron excision ratio 2 0 1.71
NAcc mRNA stability 4 0.1 1.74
OFC alternative polyA 0 0 1.94
OFC alternative TSS 0 0 1.85
OFC gene expression 2 0 1.77
OFC isoform ratio 0 0 1.65
OFC intron excision ratio 0 0 1.69
OFC mRNA stability 1 0.1 1.8
PL alternative polyA 1 0 1.76
PL alternative TSS 4 0.1 1.79
PL gene expression 6 0.1 1.78
PL isoform ratio 3 0.1 1.82
PL intron excision ratio 1 0 1.74
PL mRNA stability 5 0.1 1.75
pVTA alternative polyA 2 0.1 1.97
pVTA alternative TSS 0 0 1.66
pVTA gene expression 5 0.1 1.8
pVTA isoform ratio 1 0 1.76
pVTA intron excision ratio 0 0 1.74
pVTA mRNA stability 1 0.1 1.77
RMTg alternative polyA 0 0 1.82
RMTg alternative TSS 0 0 1.82
RMTg gene expression 2 0.1 1.72
RMTg isoform ratio 0 0 1.85
RMTg intron excision ratio 0 0 1.55
RMTg mRNA stability 3 0.5 1.84