Hub : Traits

Bone: maximum force

Tags: Physiology · Bone

Project: r01_doug_adams

5 loci · 9 genes with independent associations · 153 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	130477356	133751683	147	4	6.62e-09	2.10e-08	1.00e+00	Ccdc65 Faim2 Tmbim6 Tuba1a
2	chr8	117463629	118343328	1	1	4.27e-34	2.91e-01	1.00e+00	Mst1
3	chr9	83390749	84777604	1	1	0.00e+00	2.37e-02	1.00e+00	Retreg2
4	chr10	106734264	107706829	2	1	8.72e-10	6.68e-09	5.89e-02	Zfp950l6
5	chr16	2120344	3518593	2	2	3.77e-08	6.75e-08	1.00e+00	Erc2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	9.37	45	8	88.9	0.15	4.19e-03	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
BMI without tail	57243.66	1	1	11.1	0	1.00e+00	Retreg2
Body weight	6.96	48	45	500	0.67	2.80e-47	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Epididymis fat weight	18149.94	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Glucose	336.01	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Heart weight	3065.65	1	1	11.1	0	1.00e+00	Retreg2
Left kidney weight	55046.11	1	1	11.1	0	1.00e+00	Retreg2
Right kidney weight	118.21	46	2	22.2	-0.63	2.26e-41	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Tail length	28919.24	1	1	11.1	0	1.00e+00	Retreg2
Length with tail	747.9	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Length without tail	138.87	46	2	22.2	-0.63	6.67e-40	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Liver weight, left	20.65	45	2	22.2	-0.11	4.59e-02	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Liver weight, right	44.57	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Parametrial fat weight	181.56	1	1	11.1	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1985.63	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Intraocular pressure	10386.52	1	1	11.1	0	1.00e+00	Retreg2
Extensor digitorum longus weight	8.28	45	1	11.1	0.98	9.53e-197	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Soleus weight	20.71	1	1	11.1	0	1.00e+00	Retreg2
Tibialis anterior weight	1158.38	1	1	11.1	0	1.00e+00	Retreg2
Tibia length	9.78	44	4	44.4	0.92	5.12e-143	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dnajc22 Faim2 Fkbp11 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Number of licking bursts	67424.86	1	1	11.1	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	17761.06	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Times rat made contact with spout	71.66	1	1	11.1	0	1.00e+00	Retreg2
Mean time between licks in bursts	111630.35	1	1	11.1	0	1.00e+00	Retreg2
Mean num. licks in bursts	56750.08	1	1	11.1	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	34168.6	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	25114.54	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Indifference point function ln k	27906.36	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Indifference point function log k	27906.36	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 0 sec	41947.04	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging total patch changes 12 sec	1182.87	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 18 sec	20236.6	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 24 sec	37424.62	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 6 sec	7787.09	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging time to switch 0 sec	66489.31	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	60426.37	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	70639.93	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	33728.57	1	1	11.1	0	1.00e+00	Retreg2
Patch foraging water rate 24 sec	523.92	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	837.86	1	1	11.1	0	1.00e+00	Retreg2
Locomotor activity	26.79	1	1	11.1	0	1.00e+00	Mst1
Locomotor testing distance	13845.45	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Locomotor testing rearing	31715.18	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Light reinforcement 1	66311.75	1	1	11.1	0	1.00e+00	Retreg2
Light reinforcement 2	18398.05	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Reaction time number correct	63471.78	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean minus median	19996.96	5	1	11.1	0.99	4.03e-05	Adcy6 Asic1 Dnajc22 Prpf40b Retreg2
Reaction time mean minus median AUC	62004.19	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms	7685.9	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	17513.8	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	63471.78	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials on left	60883.54	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean	29724.21	1	1	11.1	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	11.1	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	11.1	0	1.00e+00	Retreg2
Reaction time omissions	53.76	31	1	11.1	0.55	2.37e-16	Adcy6 Asb8 Bcdin3d Cacnb3 Ccdc65 Ccnt1 Cers5 Dnajc22 Faim2 Fkbp11 Kansl2 Kcnh3 Kmt2d Lmbr1l LOC102546778 LOC120093830 LOC134479571 Mcrs1 Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Zfp641
Reaction time false alarm rate	111.7	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Reaction time premature initiation rate	9733.76	1	1	11.1	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	11.1	0	1.00e+00	Retreg2
Std. dev. reaction times	30437.76	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Reaction time trials completed	60883.54	1	1	11.1	0	1.00e+00	Retreg2
Reaction time trials AUC	62130.65	1	1	11.1	0	1.00e+00	Retreg2
Social response proportion	4397.95	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Social responses	640.25	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Social time	11650.06	1	1	11.1	0	1.00e+00	Retreg2
Conditioned locomotion	1400.08	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	11.1	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	11.1	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	28713.86	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active responses	1165.18	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	5466.41	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1963.38	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	39811.91	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. index score	6407.33	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	17558.57	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	100795.1	1	1	11.1	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	32505.31	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	5172.85	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Intermittent access intake day 1-15 change	63945.95	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation	63041.23	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation 2	36175.43	1	1	11.1	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	90342.67	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Intermitt. access day 15 inactive lever presses	123608.2	1	1	11.1	0	1.00e+00	Retreg2
Intermitt. access escalation Index	46701.01	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Intermittent access day 1 total infusions	33063.01	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	48731.91	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access total infusions	181.04	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 1 locomotion	34964.22	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	85548.8	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access total locomotion	116.36	1	1	11.1	0	1.00e+00	Retreg2
Intermittent access standard deviation	56995.61	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Cocaine induced anxiety	69097.7	1	1	11.1	0	1.00e+00	Retreg2
Post-drug Anxiety	4753.56	1	1	11.1	0	1.00e+00	Retreg2
Baseline Anxiety	33506.24	1	1	11.1	0	1.00e+00	Retreg2
Lifetime Intake	1655.49	1	1	11.1	0	1.00e+00	Retreg2
Incentive Sensitization - Responses	71347.91	1	1	11.1	0	1.00e+00	Retreg2
Incentive Sensitization - Breakpoint	55273.76	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 active lever presses	31979.35	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	30292.17	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	31120.43	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Progressive ratio test 2 active lever presses	15263.76	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 2 breakpoint	8542.35	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	72504.33	1	1	11.1	0	1.00e+00	Retreg2
Total sessions with >9 infusions	1005.82	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Short access day 1 total inactive lever presses	19749.92	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Short access day 10 total inactive lever presses	69453.48	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Short access day 1 total infusions	38385.19	1	1	11.1	0	1.00e+00	Retreg2
Short access day 10 total infusions	11366.61	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Short access total infusions	8778.92	1	1	11.1	0	1.00e+00	Retreg2
Short access day 1 locomotion	24803.24	1	1	11.1	0	1.00e+00	Retreg2
Short access day 10 total locomotion	44094.34	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Short access total locomotion	9355.68	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Compulsive drug intake	18679.82	1	1	11.1	0	1.00e+00	Retreg2
One hour access (0.3 mA shock)	2329.1	1	1	11.1	0	1.00e+00	Retreg2
One hour access (shock baseline)	54988.81	1	1	11.1	0	1.00e+00	Retreg2
Number of responses in last shaping day	13618.48	1	1	11.1	0	1.00e+00	Retreg2
Context. condit. distance diff. score	212.47	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 1	3523.61	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 1	1024.77	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 2	1110.36	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	508.11	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 3	507.49	1	1	11.1	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	507.07	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving bouts, day 7	2509.72	1	1	11.1	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	2115.93	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, session 8	144.71	2	1	11.1	0	1.00e+00	Erc2 Retreg2
Locomotion distance, session 8	147.88	1	1	11.1	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	2042.98	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	11.1	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	2347.96	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Incentive salience index mean	1780.77	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	429.72	1	1	11.1	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	11.1	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	38.53	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Total locomotion distance, hab. session 2	22.17	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	11.1	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7678.6	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	1935.62	1	1	11.1	0	1.00e+00	Retreg2
Total locomotion distance, NPP test	1687.31	1	1	11.1	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	276.98	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. index score	214.07	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	372.95	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	491.61	1	1	11.1	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	82.71	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	303.26	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Bone: apparent density	27.12	37	1	11.1	1	0.00e+00	Adcy6 Asb8 Asic1 Bcdin3d Cacnb3 Ccdc65 Ccnt1 Cers5 Ddx23 Dnajc22 Faim2 Fkbp11 Kansl2 Kcnh3 Kmt2d Lmbr1l LOC102546594 LOC102546778 LOC120093830 LOC134479571 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone surface	29.07	45	2	22.2	1	0.00e+00	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone volume	35	43	1	11.1	0.99	1.69e-284	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone: connectivity density	1667.52	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical apparent density	12020.36	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical area	26.18	40	3	33.3	1	0.00e+00	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Ddx23 Dnajc22 Erc2 Faim2 Fkbp11 Kansl2 Kcnh3 Kmt2d Lmbr1l LOC102546594 LOC102546778 LOC120093830 LOC134479571 Mcrs1 Mst1 Prkag1 Prpf40b Prph Retreg2 Rhebl1 Rnd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: cortical porosity	432.96	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical porosity	1113.18	1	1	11.1	0	1.00e+00	Retreg2
Bone: cortical thickness	159.9	3	2	22.2	0	1.00e+00	Mst1 Retreg2 Zfp950l6
Bone: cortical thickness	1488.54	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Bone: cortical tissue density	13002.58	1	1	11.1	0	1.00e+00	Retreg2
Bone: elastic displacement	7604.03	1	1	11.1	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	32.94	46	1	11.1	0.99	3.33e-279	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone: endosteal perimeter	46.73	45	1	11.1	0.97	6.42e-188	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone: final force	16.32	49	3	33.3	0.95	5.06e-179	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: final moment	13.46	49	3	33.3	0.79	1.36e-78	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: marrow area	34.15	47	1	11.1	0.98	1.14e-258	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone: maximum diameter	2047.77	3	2	22.2	0	1.00e+00	Mst1 Retreg2 Zfp950l6
Bone: maximum moment	34.37	49	49	544.4	0.99	0.00e+00	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: minimum diameter	21.23	47	2	22.2	1	0.00e+00	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641
Bone: periosteal estimation	40.11	49	33	366.7	1	0.00e+00	Adcy6 Asb8 Asic1 B3gntl1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: periosteal perimeter	43.26	47	2	22.2	0.99	4.26e-291	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: post-yield work	481.39	20	1	11.1	0.99	7.64e-28	Bcdin3d C1ql4 Ccdc65 Dnajc22 Faim2 Kansl2 Kcnh3 Kmt2d Lmbr1l LOC102546594 LOC102546778 LOC134479571 Mcrs1 Mst1 Prkag1 Prph Retreg2 Spats2 Tuba1a Tuba1b
Bone: stiffness	44.26	48	46	511.1	1	0.00e+00	Adcy6 Asb8 Asic1 Bcdin3d C1ql4 Cacnb3 Ccdc65 Ccnt1 Cers5 Cox14 Ddx23 Dip2b Dnajc22 Erc2 Faim2 Fkbp11 Fmnl3 Kansl2 Kcnh3 Kmt2d Lima1 Lmbr1l LOC100362820 LOC102546594 LOC102546778 LOC102549417 LOC120093830 LOC134479571 Mcrs1 Mst1 Nckap5l Prkag1 Prpf40b Prph Racgap1 Retreg2 Rhebl1 Rnd1 Smarcd1 Spats2 Tmbim6 Troap Tuba1a Tuba1b Tuba1c Wnt10b Zfp641 Zfp950l6
Bone: tissue strength	2995.95	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular number	10739.78	1	1	11.1	0	1.00e+00	Retreg2
Bone: trabecular spacing	3991.76	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Bone: trabecular thickness	4257.4	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	7288.79	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Breakpoint value in progressive ratio session	18809.48	2	1	11.1	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	50534.09	1	1	11.1	0	1.00e+00	Retreg2
Distance traveled after self-admin	32464.08	1	1	11.1	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	244.69	1	1	11.1	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	15131.21	1	1	11.1	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	18336.8	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Extinction: sum of active levers before priming	14221.72	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Active lever presses in extinction session 6	384.74	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Delta distance traveled before/after self-admin	2940.47	1	1	11.1	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	30849.75	1	1	11.1	0	1.00e+00	Retreg2
Time in closed arm before self-admin	13457.43	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Time in closed arm after self-admin	2326.29	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Time in open arm before self-admin	8746.25	1	1	11.1	0	1.00e+00	Retreg2
Time in open arm after self-admin	277.78	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Sum of active levers in priming session hrs 5-6	978.69	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	6696.83	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Time to tail flick, vehicle, after self-admin	42142.71	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	8139.55	1	1	11.1	0	1.00e+00	Retreg2
Time to tail flick, test, after self-admin	1399.18	1	1	11.1	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	4924	2	2	22.2	0	1.00e+00	Mst1 Retreg2
Delta time to tail flick, test, before/after SA	15684.59	1	1	11.1	0	1.00e+00	Retreg2
Ambulatory time before self-admin	78874.38	1	1	11.1	0	1.00e+00	Retreg2
Ambulatory time after self-admin	26614.91	1	1	11.1	0	1.00e+00	Retreg2
Total heroin consumption	240.55	1	1	11.1	0	1.00e+00	Retreg2
Area under the delay curve	24791.27	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	21959.9	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	32437.06	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 4s delay	616.19	1	1	11.1	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	11.1	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	11.1	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	11.1	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	11.1	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	5669.94	1	1	11.1	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	13009.3	1	1	11.1	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	10785.17	1	1	11.1	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	11.1	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	22349.64	1	1	11.1	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	68821.85	1	1	11.1	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	11.1	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	71159.6	1	1	11.1	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	82029.05	1	1	11.1	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	99042.67	1	1	11.1	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	25503.09	1	1	11.1	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	8477.87	1	1	11.1	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	53555.35	1	1	11.1	0	1.00e+00	Retreg2
Weight adjusted by age	70782.25	1	1	11.1	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	13445.31	1	1	11.1	0	1.00e+00	Retreg2
Locomotion in novel chamber	3903.37	1	1	11.1	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	65422.89	1	1	11.1	0	1.00e+00	Retreg2
Progressive ratio	67888.93	1	1	11.1	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	1875.34	1	1	11.1	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	41283.25	1	1	11.1	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	11.1	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	7664.74	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	7166.92	1	1	11.1	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	1716.51	1	1	11.1	0	1.00e+00	Retreg2
Co content in liver	1133.25	1	1	11.1	0	1.00e+00	Retreg2
Cu content in liver	39.92	1	1	11.1	0	1.00e+00	Retreg2
Fe content in liver	1344.53	1	1	11.1	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	11.1	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	11.1	0	1.00e+00	Retreg2
Mn content in liver	1009.39	1	1	11.1	0	1.00e+00	Retreg2
Na content in liver	4018.36	1	1	11.1	0	1.00e+00	Retreg2
Rb content in liver	87.87	1	1	11.1	0	1.00e+00	Retreg2
Zn content in liver	3745.55	1	1	11.1	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	1	0	1.7
Adipose	alternative TSS	4	0.1	1.75
Adipose	gene expression	11	0.1	1.67
Adipose	isoform ratio	6	0.1	1.73
Adipose	intron excision ratio	1	0	1.65
Adipose	mRNA stability	3	0.1	1.68
BLA	alternative polyA	7	0.3	1.8
BLA	alternative TSS	0	0	1.58
BLA	gene expression	14	0.2	1.79
BLA	isoform ratio	6	0.2	1.88
BLA	intron excision ratio	5	0.2	1.67
BLA	mRNA stability	3	0.1	1.69
Brain	alternative polyA	6	0.2	1.76
Brain	alternative TSS	7	0.2	1.71
Brain	gene expression	20	0.2	1.7
Brain	isoform ratio	9	0.2	1.76
Brain	intron excision ratio	10	0.2	1.64
Brain	mRNA stability	7	0.1	1.67
Eye	alternative polyA	0	0	2.23
Eye	alternative TSS	0	0	1.84
Eye	gene expression	4	0.3	1.83
Eye	isoform ratio	1	0.2	2.23
Eye	intron excision ratio	1	0.1	1.56
Eye	mRNA stability	0	0	1.69
IC	alternative polyA	3	0.2	1.79
IC	alternative TSS	1	0.1	1.79
IC	gene expression	8	0.1	1.79
IC	isoform ratio	5	0.2	1.88
IC	intron excision ratio	1	0	1.77
IC	mRNA stability	1	0.1	1.67
IL	alternative polyA	2	0.2	1.86
IL	alternative TSS	0	0	1.55
IL	gene expression	8	0.2	1.82
IL	isoform ratio	2	0.2	1.85
IL	intron excision ratio	1	0.1	1.77
IL	mRNA stability	3	0.2	1.78
LHb	alternative polyA	3	0.3	1.92
LHb	alternative TSS	0	0	1.66
LHb	gene expression	13	0.3	1.79
LHb	isoform ratio	2	0.2	1.76
LHb	intron excision ratio	0	0	1.55
LHb	mRNA stability	3	0.2	1.62
Liver	alternative polyA	3	0.1	1.75
Liver	alternative TSS	5	0.2	1.79
Liver	gene expression	5	0.1	1.69
Liver	isoform ratio	3	0.1	1.77
Liver	intron excision ratio	1	0	1.53
Liver	mRNA stability	3	0.1	1.62
NAcc	alternative polyA	4	0.1	6.09
NAcc	alternative TSS	2	0.1	1.72
NAcc	gene expression	13	0.1	1.73
NAcc	isoform ratio	5	0.1	1.77
NAcc	intron excision ratio	10	0.2	1.72
NAcc	mRNA stability	6	0.2	1.69
OFC	alternative polyA	2	0.2	2.02
OFC	alternative TSS	2	0.3	1.65
OFC	gene expression	8	0.2	1.76
OFC	isoform ratio	3	0.2	1.81
OFC	intron excision ratio	2	0.2	1.85
OFC	mRNA stability	2	0.2	1.66
PL	alternative polyA	4	0.1	1.77
PL	alternative TSS	15	0.5	1.81
PL	gene expression	20	0.2	1.76
PL	isoform ratio	11	0.2	1.81
PL	intron excision ratio	10	0.2	1.73
PL	mRNA stability	6	0.2	1.7
pVTA	alternative polyA	4	0.2	1.81
pVTA	alternative TSS	3	0.1	1.83
pVTA	gene expression	12	0.2	1.77
pVTA	isoform ratio	4	0.1	1.82
pVTA	intron excision ratio	2	0	1.73
pVTA	mRNA stability	3	0.1	1.64
RMTg	alternative polyA	0	0	1.68
RMTg	alternative TSS	2	0.4	1.87
RMTg	gene expression	2	0.1	1.8
RMTg	isoform ratio	1	0.1	1.89
RMTg	intron excision ratio	1	0.1	1.59
RMTg	mRNA stability	2	0.3	1.66