Hub : Traits

Time in novel zone, hab. session 2

Time in novel zone during second habituation session for males and females [sec]

Tags: Behavior · Motivation · Novelty

Project: p50_shelly_flagel_2014

3 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 1.6e-14 NaN NA NA NA
2 11 39057816 40174684 1 1 3.7e-08 0.16 1 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 171.8 1 1 50 0 1 NA
Body weight 6.7 2 1 50 0 1 Shld1 NA
Epididymis fat weight 136.2 1 1 50 0 1 NA
Glucose 6.6 1 0 0 0 1 NA
Heart weight 7.9 2 0 0 0 1 Epha6 NA
Left kidney weight 62.7 1 1 50 0 1 NA
Right kidney weight 67.3 1 1 50 0 1 NA
Tail length 91.1 1 1 50 0 1 NA
Length with tail 4.0 1 0 0 0 1 NA
Length without tail 120.2 1 1 50 0 1 NA
Liver weight, left 23.6 1 1 50 0 1 NA
Liver weight, right 9.6 1 0 0 0 1 NA
Parametrial fat weight 22.4 2 2 100 0 1 Epha6 NA
Retroperitoneal fat weight 4.2 1 0 0 0 1 NA
Intraocular pressure 17.3 2 1 50 0 1 Epha6 NA
Extensor digitorum longus weight 39.2 1 1 50 0 1 NA
Soleus weight 13.9 2 1 50 0 1 Shld1 NA
Tibialis anterior weight 49.2 2 1 50 0 1 Shld1 NA
Tibia length 4.9 2 0 0 0 1 Epha6 NA
Number of licking bursts 242.4 1 1 50 0 1 NA
Food consumed during 24 hour testing period 11.3 2 0 0 0 1 Epha6 NA
Times rat made contact with spout 68.1 2 1 50 0 1 Epha6 NA
Mean time between licks in bursts 48.4 2 1 50 0 1 Shld1 NA
Mean num. licks in bursts 258.2 1 1 50 0 1 NA
Std. dev. time between licks in bursts 148.4 2 1 50 0 1 Shld1 NA
Water consumed over 24 hours 10.2 2 0 0 0 1 Epha6 NA
Indifference point 0 sec 13.3 2 1 50 0 1 Shld1 NA
Indifference point AUC 36.3 2 1 50 0 1 Shld1 NA
Indifference point function ln k 4.4 1 0 0 0 1 NA
Indifference point function log k 4.4 1 0 0 0 1 NA
Delay discounting total patch changes 0 sec 12.1 2 1 50 0 1 Shld1 NA
Delay discounting total patch changes 12 sec 59.9 3 1 50 0 1 Shld1 Epha6 NA
Delay discounting total patch changes 18 sec 147.0 2 1 50 0 1 Epha6 NA
Delay discounting total patch changes 24 sec 43.7 1 1 50 0 1 NA
Delay discounting total patch changes 6 sec 57.8 3 1 50 0 1 Shld1 Epha6 NA
Delay discounting water rate 0 sec 11.8 1 0 0 0 1 NA
Delay discounting water rate 12 sec 44.2 1 1 50 0 1 NA
Delay discounting water rate 18 sec 10.4 2 0 0 0 1 Epha6 NA
Delay discounting water rate 24 sec 100.9 1 1 50 0 1 NA
Delay discounting water rate 6 sec 70.2 1 1 50 0 1 NA
Locomotor activity 7.9 1 0 0 0 1 Epha6
Locomotor testing distance 11.5 2 0 0 0 1 Epha6 NA
Locomotor testing rearing 23.9 1 1 50 0 1 NA
Light reinforcement 1 84.1 1 1 50 0 1 NA
Reaction time number correct 9.4 1 0 0 0 1 NA
Reaction time num false alarms 90.1 1 1 50 0 1 NA
Reaction time num false alarms AUC 128.2 1 1 50 0 1 NA
Reaction time trials correct on left 9.4 1 0 0 0 1 NA
Reaction time trials on left 10.3 1 0 0 0 1 NA
Reaction time mean 62.5 1 1 50 0 1 NA
Reaction time mean AUC 89.1 1 1 50 0 1 NA
Median of all reaction times 80.2 1 1 50 0 1 NA
Reaction time false alarm rate 54.5 2 1 50 0 1 Shld1 NA
Reaction time premature initiation rate 27.5 2 1 50 0 1 Epha6 NA
Reaction time premature initiations 26.9 2 1 50 0 1 Epha6 NA
Std. dev. reaction times 27.0 1 1 50 0 1 NA
Reaction time trials completed 10.3 1 0 0 0 1 NA
Reaction time trials AUC 15.6 1 0 0 0 1 NA
Social responses 108.6 1 1 50 0 1 NA
Social time 7.8 1 0 0 0 1 NA
Conditioned locomotion 13.5 1 0 0 0 1 Epha6
Cocaine response after cond. corrected 135.7 1 1 50 0 1 NA
Cocaine response after cond. not corrected 176.6 1 1 50 0 1 NA
Cocaine response before conditioning 17.5 2 1 50 0 1 Epha6 NA
Saline control response 50.6 1 1 50 0 1 NA
Condit. Reinf. active minus inactive responses 46.4 1 1 50 0 1 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 50 0 1 NA
Condit. Reinf. active responses 11.1 1 0 0 0 1 NA
Condit. Reinf. inactive responses 20.6 1 0 0 0 1 NA
Condit. Reinf. lever presses 6.4 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 33.2 2 1 50 0 1 Epha6 NA
Pavlov. Cond. magazine entry latency 173.4 1 1 50 0 1 NA
Pavlov. Cond. change in total contacts 216.7 1 1 50 0 1 NA
Pavlov. Cond. index score 102.2 1 1 50 0 1 NA
Pavlov. Cond. latency score 110.3 1 1 50 0 1 NA
Pavlov. Cond. lever contacts 18.2 2 1 50 0 1 Epha6 NA
Pavlov. Cond. magazine entry number 125.7 2 1 50 0 1 Epha6 NA
Pavlov. Cond. intertrial magazine entries 57.4 2 1 50 0 1 Shld1 NA
Pavlov. Cond. lever-magazine prob. diff. 90.6 1 1 50 0 1 NA
Pavlov. Cond. response bias 27.9 2 1 50 0 1 Epha6 NA
Conditioned reinforcement - actives 20.1 2 0 0 0 1 Epha6 NA
Conditioned reinforcement - inactives 31.7 1 1 50 0 1 Epha6
Conditioned locomotion 9.9 1 0 0 0 1 NA
Intermittent access intake day 1-15 change 104.0 1 1 50 0 1 NA
Intermittent access intake escalation 141.1 1 1 50 0 1 NA
Intermittent access intake escalation 2 42.5 1 1 50 0 1 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 50 0 1 NA
Intermitt. access escalation Index 9.2 1 0 0 0 1 NA
Intermittent access day 1 total infusions 31.9 2 1 50 0 1 Epha6 NA
Intermittent access day 15 total infusions 13.6 1 0 0 0 1 Epha6
Intermittent access terminal intake (last 3 days) 20.1 1 0 0 0 1 Epha6
Intermittent access total infusions 18.3 1 0 0 0 1 Epha6
Intermittent access day 1 locomotion 27.1 1 1 50 0 1 NA
Cocaine induced anxiety 17.6 1 0 0 0 1 Epha6
Post-drug Anxiety 13.2 2 0 0 0 1 Epha6 NA
Baseline Anxiety 19.8 1 0 0 0 1 Epha6
Lifetime Intake 33.5 1 1 50 0 1 Epha6
Incentive Sensitization - Responses 8.0 1 0 0 0 1 Epha6
Incentive Sensitization - Breakpoint 8.0 1 0 0 0 1 Epha6
Progressive ratio test 1 active lever presses 18.2 2 0 0 0 1 Epha6 NA
Progressive ratio test 1 breakpoint 19.8 2 1 50 0 1 Epha6 NA
Progressive ratio test 1 inactive lever presses 9.5 2 0 0 0 1 Epha6 NA
Progressive ratio test 2 active lever presses 21.5 2 1 50 0 1 Epha6 NA
Progressive ratio test 2 breakpoint 42.8 2 2 100 0 1 Epha6 NA
Progressive ratio test 2 inactive lever presses 29.2 1 1 50 0 1 Epha6
Total sessions with >9 infusions 18.4 1 0 0 0 1 Epha6
Short access day 1 total inactive lever presses 6.4 1 0 0 0 1 Epha6
Short access day 10 total inactive lever presses 10.0 2 0 0 0 1 Shld1 NA
Short access day 1 total infusions 40.0 1 1 50 0 1 Epha6
Short access day 10 total infusions 24.0 1 1 50 0 1 NA
Short access total infusions 43.9 1 1 50 0 1 Epha6
Short access day 1 locomotion 17.2 1 0 0 0 1 NA
Compulsive drug intake 45.4 1 1 50 0 1 NA
One hour access (0.3 mA shock) 23.7 2 1 50 0 1 Epha6 NA
One hour access (shock baseline) 19.7 1 0 0 0 1 Epha6
Context. condit. distance diff. score 240.2 1 1 50 0 1 NA
Locomotion velocity, session 1 190.8 1 1 50 0 1 NA
Locomotion distance, session 1 310.5 2 1 50 0 1 Epha6 NA
Locomotion velocity, session 2 139.6 1 1 50 0 1 NA
Locomotion distance, session 2 1269.9 1 1 50 0 1 NA
Locomotion velocity, session 3 178.9 1 1 50 0 1 NA
Locomotion distance, session 3 117.5 1 1 50 0 1 NA
Stereotopy head waving bouts, day 3 8.9 2 0 0 0 1 Epha6 NA
Stereotopy head waving duration, day 3 33.2 1 1 50 0 1 NA
Locomotion velocity, session 7 39.7 3 1 50 0 1 Shld1 Epha6 NA
Locomotion distance, session 7 21.6 2 1 50 0 1 Epha6 NA
Stereotopy head waving bouts, day 7 68.4 1 1 50 0 1 NA
Stereotopy head waving duration, day 7 102.2 1 1 50 0 1 NA
Locomotion distance, session 8 88.6 2 1 50 0 1 Epha6 NA
Degree of sensitization distance 102.3 2 1 50 0 1 Epha6 NA
Degree of sensitization stereotypy 37.5 1 1 50 0 1 NA
Condit. Reinf. active minus inactive responses 7.5 2 0 0 0 1 Epha6 NA
Condit. Reinf. active-inactive response ratio 58.4 2 1 50 0 1 Epha6 NA
Condit. Reinf. active responses 14.8 2 0 0 0 1 Epha6 NA
Condit. Reinf. inactive responses 12.3 2 0 0 0 1 Shld1 NA
Incentive salience index mean 13.2 2 0 0 0 1 Epha6 NA
Condit. Reinf. lever presses 23.0 2 1 50 0 1 Epha6 NA
Time in familiar zone, hab. session 1 18.8 3 1 50 0 1 Shld1 Epha6 NA
Time in novel zone, hab. session 1 11.7 3 0 0 0 1 Shld1 Epha6 NA
Total zone transitions, hab. session 1 229.0 3 1 50 0 1 Shld1 Epha6 NA
Total locomotion distance, hab. session 1 142.1 2 1 50 0 1 Epha6 NA
Locomotion velocity, hab. session 1 178.8 2 1 50 0 1 Epha6 NA
Time in familiar zone, hab. session 2 40.8 3 3 150 0 1 Shld1 Epha6 NA
Total zone transitions, hab. session 2 214.3 2 1 50 0 1 Epha6 NA
Total locomotion distance, hab. session 2 111.6 2 1 50 0 1 Epha6 NA
Locomotion velocity, hab. session 2 117.0 2 1 50 0 1 Epha6 NA
Novelty place preference 5.8 1 0 0 0 1 Epha6
Total zone transitions, NPP test 376.1 1 1 50 0 1 NA
Total locomotion distance, NPP test 269.3 1 1 50 0 1 NA
Locomotion velocity, NPP test 317.8 1 1 50 0 1 NA
Pavlov. Cond. lever latency 14.4 2 0 0 0 1 Epha6 NA
Pavlov. Cond. magazine entry latency 65.5 2 2 100 0 1 Epha6 NA
Pavlov. Cond. change in total contacts 24.2 2 1 50 0 1 Epha6 NA
Pavlov. Cond. index score 40.5 2 2 100 0 1 Epha6 NA
Pavlov. Cond. latency score 21.7 2 1 50 0 1 Epha6 NA
Pavlov. Cond. lever contacts 20.9 2 1 50 0 1 Epha6 NA
Pavlov. Cond. magazine entry number 38.2 2 1 50 0 1 Epha6 NA
Pavlov. Cond. intertrial magazine entries 5.5 1 0 0 0 1 Shld1
Pavlov. Cond. lever-magazine prob. diff. 57.9 2 2 100 0 1 Epha6 NA
Pavlov. Cond. response bias 41.0 2 2 100 0 1 Epha6 NA
Bone: apparent density 31.2 1 1 50 0 1 NA
Bone surface 22.8 2 1 50 0 1 Epha6 NA
Bone volume 25.9 2 1 50 0 1 Shld1 NA
Bone: connectivity density 8.5 1 0 0 0 1 NA
Bone: cortical apparent density 4.9 1 0 0 0 1 Shld1
Bone: cortical area 4.4 1 0 0 0 1 Shld1
Bone: cortical porosity 188.5 1 1 50 0 1 NA
Bone: cortical porosity 80.7 2 1 50 0 1 Epha6 NA
Bone: cortical thickness 8.8 1 0 0 0 1 NA
Bone: cortical thickness 15.9 2 0 0 0 1 Epha6 NA
Bone: cortical tissue density 5.8 1 0 0 0 1 Shld1
Bone: elastic displacement 28.2 1 1 50 0 1 NA
Bone: endosteal estimation 18.4 1 1 50 0 1 NA
Bone: final force 57.4 1 1 50 0 1 NA
Bone: final moment 45.6 1 1 50 0 1 NA
Bone: marrow area 15.3 1 1 50 0 1 NA
Bone: maximum diameter 7.1 2 0 0 0 1 Shld1 Epha6
Bone: maximum force 60.3 1 1 50 0 1 NA
Bone: maximum moment 41.2 1 1 50 0 1 NA
Bone: minimum diameter 86.7 1 1 50 0 1 NA
Bone: periosteal estimation 6.5 2 0 0 0 1 Epha6 NA
Bone: periosteal perimeter 6.8 2 0 0 0 1 Epha6 NA
Bone: post-yield work 124.3 1 1 50 0 1 NA
Bone: stiffness 72.3 2 1 50 0 1 Epha6 NA
Bone: tissue strength 136.0 1 1 50 0 1 NA
Bone: trabecular number 64.1 1 1 50 0 1 NA
Bone: trabecular spacing 5.7 1 0 0 0 1 NA
Bone: trabecular thickness 13.8 1 0 0 0 1 NA
Bone: trabecular tissue density 36.1 2 1 50 0 1 Shld1 NA
Distance traveled before self-admin 12.6 1 0 0 0 1 NA
Delta time in open arm before/after self-admin 40.2 1 1 50 0 1 NA
Extinction: sum of active levers before priming 12.2 1 0 0 0 1 NA
Active lever presses in extinction session 6 9.2 1 0 0 0 1 NA
Delta distance traveled before/after self-admin 11.3 1 0 0 0 1 NA
Time in closed arm before self-admin 78.0 1 1 50 0 1 NA
Time in closed arm after self-admin 40.2 1 1 50 0 1 NA
Time in open arm after self-admin 31.3 1 1 50 0 1 NA
Time to tail flick, test, before self-admin 6.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 7.8 2 0 0 0 1 Epha6 NA
Delta time to tail flick, test, before/after SA 15.4 2 0 0 0 1 Shld1 NA
Ambulatory time before self-admin 5.7 1 0 0 0 1 NA
Total heroin consumption 5.1 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.8 1 0 0 0 1 Epha6
Delay disc. indifference point, 4s delay 7.8 2 0 0 0 1 Shld1 Epha6
Delay disc. indifference point, 8s delay 13.0 1 0 0 0 1 Shld1
Fecal boli incidents, locomotor time 1 11.8 1 0 0 0 1 NA
Change in fecal boli incidents, locomotor task 8.8 1 0 0 0 1 NA
Time >=10cm from walls, locomotor time 1 12.8 2 0 0 0 1 Epha6 NA
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 2 27.2 1 1 50 0 1 NA
Total resting periods, locomotor time 2 6.0 1 0 0 0 1 NA
Rest time, locomotor task time 2 7.3 2 0 0 0 1 Epha6 NA
Distance moved, locomotor task time 2 13.1 1 0 0 0 1 NA
Weight adjusted by age 25.0 1 1 50 0 1 NA
Seeking ratio, delayed vs. immediate footshock 8.3 2 0 0 0 1 Epha6 NA
Locomotion in novel chamber 10.2 1 0 0 0 1 NA
Locomotion in novel chamber post-restriction 15.5 1 0 0 0 1 Epha6
Progressive ratio 11.7 1 0 0 0 1 Shld1
Seeking ratio, punishment vs. effort 5.0 1 0 0 0 1 Shld1
Run reversals in cocaine runway, males 39.3 1 1 50 0 1 NA
Latency to leave start box in cocaine runway 14.5 2 0 0 0 1 Epha6 NA
Cd content in liver 239.3 1 1 50 0 1 NA
Co content in liver 143.3 1 1 50 0 1 NA
Fe content in liver 10.3 1 0 0 0 1 NA
K content in liver 87.3 1 1 50 0 1 NA
Mn content in liver 207.1 1 1 50 0 1 NA
Na content in liver 9.4 1 0 0 0 1 Epha6
Rb content in liver 31.4 1 1 50 0 1 NA
Se content in liver 30.1 2 1 50 0 1 Epha6 NA
Zn content in liver 46.0 1 1 50 0 1 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.02
Adipose alternative TSS 0 0.000 1.02
Adipose gene expression 0 0.000 0.99
Adipose isoform ratio 0 0.000 0.99
Adipose intron excision ratio 0 0.000 0.98
Adipose mRNA stability 0 0.000 1.00
BLA alternative polyA 0 0.000 1.03
BLA alternative TSS 0 0.000 1.14
BLA gene expression 0 0.000 1.01
BLA isoform ratio 0 0.000 1.10
BLA intron excision ratio 0 0.000 1.00
BLA mRNA stability 0 0.000 1.05
Brain alternative polyA 0 0.000 0.98
Brain alternative TSS 0 0.000 1.06
Brain gene expression 0 0.000 1.00
Brain isoform ratio 0 0.000 1.04
Brain intron excision ratio 0 0.000 0.99
Brain mRNA stability 0 0.000 1.02
Eye alternative polyA 0 0.000 1.04
Eye alternative TSS 0 0.000 1.11
Eye gene expression 0 0.000 1.03
Eye isoform ratio 0 0.000 1.06
Eye intron excision ratio 0 0.000 1.01
Eye mRNA stability 0 0.000 1.04
IL alternative polyA 0 0.000 1.08
IL alternative TSS 0 0.000 1.02
IL gene expression 0 0.000 1.01
IL isoform ratio 0 0.000 0.96
IL intron excision ratio 0 0.000 1.00
IL mRNA stability 0 0.000 1.04
LHb alternative polyA 0 0.000 1.14
LHb alternative TSS 0 0.000 1.20
LHb gene expression 0 0.000 1.02
LHb isoform ratio 0 0.000 1.04
LHb intron excision ratio 0 0.000 1.03
LHb mRNA stability 0 0.000 1.09
Liver alternative polyA 0 0.000 0.93
Liver alternative TSS 0 0.000 1.00
Liver gene expression 0 0.000 0.98
Liver isoform ratio 0 0.000 0.95
Liver intron excision ratio 1 0.023 0.99
Liver mRNA stability 0 0.000 1.01
NAcc alternative polyA 0 0.000 1.07
NAcc alternative TSS 0 0.000 1.04
NAcc gene expression 0 0.000 0.99
NAcc isoform ratio 0 0.000 1.04
NAcc intron excision ratio 0 0.000 0.97
NAcc mRNA stability 0 0.000 0.98
OFC alternative polyA 0 0.000 1.08
OFC alternative TSS 0 0.000 1.25
OFC gene expression 0 0.000 1.02
OFC isoform ratio 0 0.000 1.04
OFC intron excision ratio 0 0.000 1.02
OFC mRNA stability 0 0.000 1.00
PL alternative polyA 0 0.000 1.05
PL alternative TSS 1 0.085 1.21
PL gene expression 0 0.000 1.01
PL isoform ratio 1 0.045 1.07
PL intron excision ratio 0 0.000 0.96
PL mRNA stability 0 0.000 1.02

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.